Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RBM47	54502	broad.mit.edu	37	4	40440107	40440107	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr4:40440107C>G	uc003gvc.2	-	3	1514	c.804G>C	c.(802-804)caG>caC	p.Q268H	RBM47_uc003gvd.2_Missense_Mutation_p.Q268H|RBM47_uc003gve.2_Non-coding_Transcript|RBM47_uc011bys.1_Missense_Mutation_p.Q230H|RBM47_uc003gvg.1_Missense_Mutation_p.Q268H	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	Homo sapiens RNA binding motif protein 47 (RBM47), transcript variant 1, mRNA.	268	RRM 3.					nucleus	RNA binding|nucleotide binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						CGGGGTTGAACTGGCCGAAGC	0.592000														75			5		0	0	0.021553	0	0
CUL9	23113	broad.mit.edu	37	6	43152353	43152353	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr6:43152353G>A	uc003ouk.3	+	1	380	c.305G>A	c.(304-306)cGa>cAa	p.R102Q	CUL9_uc003ouj.1_Missense_Mutation_p.R102Q|CUL9_uc003oul.3_Missense_Mutation_p.R102Q|CUL9_uc010jyk.3_5'UTR|CUL9_uc003oum.1_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	Homo sapiens cullin 9 (CUL9), mRNA.	102					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						AGCTTTCCTCGAGATCCAGGA	0.602000														115			10		0	0	0.008291	0	0
BTNL8	79908	broad.mit.edu	37	5	180377319	180377319	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr5:180377319G>C	uc003mmp.3	+	7	1512	c.1278G>C	c.(1276-1278)caG>caC	p.Q426H	BTNL8_uc003mmq.3_3'UTR|BTNL8_uc010jll.3_3'UTR|BTNL8_uc011dhg.2_Missense_Mutation_p.Q301H|BTNL8_uc010jlm.3_Missense_Mutation_p.Q310H|BTNL8_uc011dhh.2_Missense_Mutation_p.Q242H	NM_001040462	NP_001153182	Q6UX41	BTNL8_HUMAN	Homo sapiens butyrophilin-like 8 (BTNL8), transcript variant 2, mRNA.	426	B30.2/SPRY.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TAAATGACCAGTCCCTTATTT	0.458000														80			12		0	0	0.016723	0	0
TTN	7273	broad.mit.edu	37	2	179600395	179600395	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr2:179600395T>G	uc021vsy.1	-	46	11271	c.11046A>C	c.(11044-11046)caA>caC	p.Q3682H	TTN_uc021vsz.1_Intron|TTN_uc021vta.1_Intron|TTN_uc021vtb.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.Q343H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	Homo sapiens titin (TTN), transcript variant N2-A, mRNA.	4609	Ig-like 22.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGGGAGTTTTTGCCCATCTT	0.418000														42			3		0	0	0.004672	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64139008	64139008	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:64139008G>A	uc003dmf.3	-	5	1223	c.637C>T	c.(637-639)Cga>Tga	p.R213*		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	Homo sapiens prickle homolog 2 (Drosophila) (PRICKLE2), mRNA.	213	LIM zinc-binding 2.					cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		TGCCAGTGTCGCCCCTCAGCT	0.498000														153			15		0	0	0.006122	0	0
NUP214	8021	broad.mit.edu	37	9	134038526	134038526	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr9:134038526T>C	uc004cag.3	+	18	2800	c.2689T>C	c.(2689-2691)Tcc>Ccc	p.S897P	NUP214_uc004cah.3_Missense_Mutation_p.S887P|NUP214_uc004cai.3_Missense_Mutation_p.S327P|NUP214_uc004caf.1_Missense_Mutation_p.S886P|NUP214_uc010mzf.3_Missense_Mutation_p.S195P	NM_005085	NP_005076	P35658	NU214_HUMAN	Homo sapiens nucleoporin 214kDa (NUP214), mRNA.	897	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GTGGAGCCTGTCCTCGGCTGT	0.488000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""									65			5		0	0	0.014758	0	0
NIPBL	25836	broad.mit.edu	37	5	36962278	36962278	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr5:36962278A>G	uc003jkl.4	+	5	1011	c.512A>G	c.(511-513)aAt>aGt	p.N171S	NIPBL_uc003jkk.4_Missense_Mutation_p.N171S|NIPBL_uc003jkm.1_Missense_Mutation_p.N50S	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	Homo sapiens Nipped-B homolog (Drosophila) (NIPBL), transcript variant A, mRNA.	171					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CCACAGCAAAATAGCCCAGTG	0.433000														176			8		0	0	0.004482	0	0
OR4M1	441670	broad.mit.edu	37	14	20248923	20248923	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr14:20248923T>A	uc010tku.2	+	0	442	c.442T>A	c.(442-444)Tcc>Acc	p.S148T		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily M, member 1 (OR4M1), mRNA.	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGTGGCTCTCTCCTGGATGGG	0.502000														185			12		0	0	0.013537	0	0
GUCY1B3	2983	broad.mit.edu	37	4	156710914	156710914	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr4:156710914C>T	uc003ipc.3	+	4	513	c.346C>T	c.(346-348)Cgt>Tgt	p.R116C	GUCY1B3_uc011cio.2_Missense_Mutation_p.R138C|GUCY1B3_uc011cip.2_Missense_Mutation_p.R96C|GUCY1B3_uc003ipd.3_Missense_Mutation_p.R44C|GUCY1B3_uc010iqf.3_Missense_Mutation_p.R116C|GUCY1B3_uc010iqg.3_Missense_Mutation_p.R44C|GUCY1B3_uc011ciq.2_Missense_Mutation_p.R44C	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	Homo sapiens guanylate cyclase 1, soluble, beta 3 (GUCY1B3), mRNA.	116					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity	p.R116H(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		CCCAGGAATGCGTGCACCTTC	0.463000														98			8		0	0	0.003080	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73280628	73280628	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr4:73280628G>A	uc003hgk.2	-	3	602	c.565C>T	c.(565-567)Cag>Tag	p.Q189*		NM_014243	NP_055058	O15072	ATS3_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 3 (ADAMTS3), mRNA.	189					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TCCTCCATCTGTTTACCTCTT	0.368000														55			6		0	0	0.029380	0	0
MB21D2	151963	broad.mit.edu	37	3	192517116	192517116	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:192517116A>C	uc011bsp.2	-	1	856	c.535T>G	c.(535-537)Ttc>Gtc	p.F179V		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	Homo sapiens Mab-21 domain containing 2 (MB21D2), mRNA.	179										endometrium(3)|kidney(1)|large_intestine(4)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	31						GTAGGTGAGAAGAAGTAGTTG	0.463000														71			4		0	0	0.009096	0	0
HNRNPU	3192	broad.mit.edu	37	1	245018852	245018852	+	Silent	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:245018852G>A	uc001iaz.1	-	11	2444	c.2226C>T	c.(2224-2226)ggC>ggT	p.G742G	HNRNPU_uc001iay.1_Silent_p.G466G|HNRNPU_uc001iba.1_Silent_p.G723G	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	Homo sapiens heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) (HNRNPU), transcript variant 1, mRNA.	742	Gly-rich.|Poly-Gly.				CRD-mediated mRNA stabilization	CRD-mediated mRNA stability complex|catalytic step 2 spliceosome|cell surface|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|RNA binding|protein binding			NS(1)|endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			TTCCTCCACCGCCACCACCTC	0.502000														91			5		0	0	0.021553	0	0
SERPINB7	8710	broad.mit.edu	37	18	61471766	61471766	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr18:61471766A>C	uc002ljl.3	+	7	1136	c.1040A>C	c.(1039-1041)aAg>aCg	p.K347T	SERPINB7_uc002ljm.3_Missense_Mutation_p.K347T|SERPINB7_uc010xet.2_Missense_Mutation_p.K330T|SERPINB7_uc010dqg.3_Missense_Mutation_p.K347T	NM_001040147	NP_003775	O75635	SPB7_HUMAN	Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 7 (SERPINB7), transcript variant 2, mRNA.	347		Reactive bond (By similarity).			regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				ATTGTAGAAAAGCAACTCCCT	0.453000														28			7		0	0	0.029380	0	0
ZNF211	10520	broad.mit.edu	37	19	58153368	58153368	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr19:58153368G>C	uc002qpr.2	+	5	2009	c.1706G>C	c.(1705-1707)gGa>gCa	p.G569A	ZNF211_uc010yhb.1_Missense_Mutation_p.G509A|ZNF211_uc002qpp.2_Missense_Mutation_p.G518A|ZNF211_uc002qpq.2_Missense_Mutation_p.G505A|ZNF211_uc002qpt.2_Missense_Mutation_p.G517A|ZNF211_uc010yhc.1_Missense_Mutation_p.G517A|ZNF211_uc010yhe.1_Missense_Mutation_p.G496A|ZNF211_uc010yhd.1_Missense_Mutation_p.G444A	NM_006385	NP_006376	Q13398	ZN211_HUMAN	Homo sapiens zinc finger protein 211 (ZNF211), transcript variant 1, mRNA.	505						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTTCACACTGGAGAAAGGCCT	0.443000														44			6		0	0	0.021553	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529328	5529328	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:5529328C>G	uc021qcw.1	-	0	1461	c.1461G>C	c.(1459-1461)agG>agC	p.R487S	HBG1_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc021qcv.1_5'Flank|OR51B5_uc001maq.2_5'Flank|UBQLN3_uc001may.1_Missense_Mutation_p.R487S	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	Homo sapiens ubiquilin 3 (UBQLN3), mRNA.	487								p.L486L(1)		NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCCATCTGGCCTCAGAGATC	0.572000														78			17		0	0	0.033300	0	0
OR2AG1	144125	broad.mit.edu	37	11	6806470	6806470	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:6806470C>G	uc001mer.2	+	0	223	c.202C>G	c.(202-204)Ctc>Gtc	p.L68V		NM_001004489	NP_001004489	Q9H205	O2AG1_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily AG, member 1 (OR2AG1), mRNA.	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCAGCTCTCTCTCATGGACCT	0.552000														165			4		0	0	0.009096	0	0
OTOGL	283310	broad.mit.edu	37	12	80750654	80750654	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:80750654A>C	uc001szd.3	+	47	5958	c.5952A>C	c.(5950-5952)caA>caC	p.Q1984H	OTOGL_uc021rba.1_Missense_Mutation_p.Q3H|OTOGL_uc009zsg.2_5'UTR	NM_173591	NP_775862			Homo sapiens otogelin-like (OTOGL), mRNA.											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TCATGATTCAAGTTCGACAGG	0.348000														39			5		0	0	0.021553	0	0
PGK2	5232	broad.mit.edu	37	6	49754266	49754266	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr6:49754266A>C	uc003ozu.3	-	0	788	c.635T>G	c.(634-636)cTt>cGt	p.L212R		NM_138733	NP_620061	P07205	PGK2_HUMAN	Homo sapiens phosphoglycerate kinase 2 (PGK2), mRNA.	212					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity	p.I211I(1)		autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					GGCTCCACCAAGTATAGCCAG	0.423000														98			6		0	0	0.021553	0	0
TRIM22	10346	broad.mit.edu	37	11	5717766	5717766	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:5717766A>C	uc001mbr.3	+	1	683	c.304A>C	c.(304-306)Aaa>Caa	p.K102Q	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.2_Missense_Mutation_p.K102Q|TRIM22_uc010qzm.2_Missense_Mutation_p.E7D|TRIM22_uc009yes.3_Missense_Mutation_p.K102Q	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	Homo sapiens tripartite motif containing 22 (TRIM22), transcript variant 1, mRNA.	102					immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			kidney(3)|large_intestine(8)|lung(9)|prostate(1)|stomach(2)	23		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		GCACCATGGAAAAAAACTCCA	0.478000														58			8		0	0	0.003080	0	0
FAM19A4	151647	broad.mit.edu	37	3	68802155	68802155	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:68802155T>C	uc021xag.1	-	3	638	c.145A>G	c.(145-147)Aag>Gag	p.K49E	FAM19A4_uc021xah.1_Missense_Mutation_p.K49E	NM_182522	NP_872328	Q96LR4	F19A4_HUMAN	Homo sapiens family with sequence similarity 19 (chemokine (C-C motif)-like), member A4 (FAM19A4), transcript variant 1, mRNA.	49						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(5)|skin(2)	10		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		GTCCCTTGCTTGATTTGGTGG	0.493000														44			4		0	0	0.014758	0	0
OR51B6	390058	broad.mit.edu	37	11	5373366	5373366	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:5373366T>C	uc010qzb.2	+	0	629	c.629T>C	c.(628-630)cTc>cCc	p.L210P	HBG1_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc021qcv.1_Intron|OR51B5_uc001maq.2_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	Homo sapiens olfactory receptor, family 51, subfamily B, member 6 (OR51B6), mRNA.	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	21		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTGGACTTTCTCATCATCTTT	0.438000														96			9		0	0	0.006214	0	0
ETF1	2107	broad.mit.edu	37	5	137846839	137846839	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr5:137846839C>T	uc003ldc.4	-	7	1078	c.913G>A	c.(913-915)Gtt>Att	p.V305I	ETF1_uc011cyv.2_Missense_Mutation_p.V291I|ETF1_uc010jex.3_Non-coding_Transcript|ETF1_uc003ldd.4_Missense_Mutation_p.V272I	NM_004730	NP_004721	P62495	ERF1_HUMAN	Homo sapiens eukaryotic translation termination factor 1 (ETF1), transcript variant 1, mRNA.	305					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|urinary_tract(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTATCTTCAACGCCAAAACAG	0.388000														63			7		0	0	0.029380	0	0
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:126707544T>G	uc003ejg.3	+	0	108	c.108T>G	c.(106-108)ggT>ggG	p.G36G		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	Homo sapiens plexin A1 (PLXNA1), mRNA.	36	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity	p.G13G(4)		breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.682000														14			14		0	0	0.014323	0	0
LMAN2L	81562	broad.mit.edu	37	2	97377656	97377656	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr2:97377656C>T	uc002swv.3	-	5	683	c.647G>A	c.(646-648)cGc>cAc	p.R216H	LMAN2L_uc002swu.3_Missense_Mutation_p.R205H|LMAN2L_uc010yuu.2_Missense_Mutation_p.R69H|LMAN2L_uc010yut.2_Missense_Mutation_p.R71H|LMAN2L_uc010yuv.2_Missense_Mutation_p.R58H|LMAN2L_uc010yuw.2_Missense_Mutation_p.R60H|LMAN2L_uc010yux.2_Missense_Mutation_p.R60H	NM_001142292	NP_001135764	Q9H0V9	LMA2L_HUMAN	Homo sapiens lectin, mannose-binding 2-like (LMAN2L), transcript variant 1, mRNA.	205	L-type lectin-like.				ER to Golgi vesicle-mediated transport|protein folding|protein transport	ER to Golgi transport vesicle|Golgi membrane|endoplasmic reticulum membrane|integral to membrane	mannose binding|metal ion binding			NS(1)|breast(1)|endometrium(1)|lung(2)|skin(1)|urinary_tract(1)	7						ATGAAGATTGCGGACAATGGC	0.562000														69			4		0	0	0.014758	0	0
PDE1C	5137	broad.mit.edu	37	7	31793050	31793050	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr7:31793050C>G	uc003tcm.2	-	17	2539	c.2078G>C	c.(2077-2079)aGg>aCg	p.R693T	PDE1C_uc003tcn.1_Missense_Mutation_p.R693T|PDE1C_uc003tco.2_Missense_Mutation_p.R753T	NM_001191057	NP_001177988	Q14123	PDE1C_HUMAN	Homo sapiens phosphodiesterase 1C, calmodulin-dependent 70kDa (PDE1C), transcript variant 2, mRNA.	693					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			CATTTTGATCCTCTGATCCAG	0.448000														260			13		0	0	0.013537	0	0
MYO5C	55930	broad.mit.edu	37	15	52567822	52567822	+	Silent	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr15:52567822G>A	uc010bff.3	-	4	705	c.543C>T	c.(541-543)gtC>gtT	p.V181V	MYO5C_uc010uga.2_Non-coding_Transcript|MYO5C_uc010ugb.2_Non-coding_Transcript|MYO5C_uc010ugc.2_Silent_p.V144V	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	Homo sapiens myosin VC (MYO5C), mRNA.	181	Myosin head-like.					myosin complex	ATP binding|actin binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		CCGATTTGCTGACGGTGGCAA	0.542000														95			7		0	0	0.029380	0	0
WDR43	23160	broad.mit.edu	37	2	29152468	29152468	+	Silent	SNP	A	T	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr2:29152468A>T	uc002rmo.2	+	10	1361	c.1329A>T	c.(1327-1329)ggA>ggT	p.G443G	Y_RNA_uc021vfi.1_5'Flank	NM_015131	NP_055946	Q15061	WDR43_HUMAN	Homo sapiens WD repeat domain 43 (WDR43), mRNA.	443						nucleolus				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	20	Acute lymphoblastic leukemia(172;0.155)					AACGTCTGGGAGCAATGGATA	0.363000														27			5		0	0	0.014758	0	0
MASTL	84930	broad.mit.edu	37	10	27454438	27454438	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr10:27454438A>G	uc001itm.3	+	5	1384	c.781A>G	c.(781-783)Acg>Gcg	p.T261A	MASTL_uc001itl.3_Missense_Mutation_p.T261A|MASTL_uc009xkw.2_Missense_Mutation_p.T261A|MASTL_uc009xkx.2_Non-coding_Transcript	NM_001172303	NP_001165774	Q96GX5	GWL_HUMAN	Homo sapiens microtubule associated serine/threonine kinase-like (MASTL), transcript variant 1, mRNA.	261	Protein kinase.				G2/M transition of mitotic cell cycle|cell division|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			breast(3)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AAAGGACACTACGCCTTATTC	0.433000														57			5		0	0	0.021553	0	0
DCST2	127579	broad.mit.edu	37	1	155004049	155004049	+	Splice_Site	SNP	C	T	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:155004049C>T	uc001fgm.3	-	4	819	c.739_splice	c.e4+1	p.L247_splice	DCST2_uc009wpb.3_Splice_Site|DCST1_uc010per.2_5'Flank|DCST1_uc001fgn.2_5'Flank|DCST1_uc010pes.2_5'Flank	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	Homo sapiens DC-STAMP domain containing 2 (DCST2), mRNA.	247						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGTTTTCTCACGGCTGGCAAG	0.597000														55			19		0	0	0.008871	0	0
CCR8	1237	broad.mit.edu	37	3	39374061	39374061	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:39374061C>G	uc010hhr.2	+	1	377	c.239C>G	c.(238-240)tCt>tGt	p.S80C	CCR8_uc003cjm.2_Intron|CCR8_uc021wwe.1_Missense_Mutation_p.S80C	NM_005201	NP_005192	P51685	CCR8_HUMAN	Homo sapiens chemokine (C-C motif) receptor 8 (CCR8), mRNA.	80					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		CTGGCCCTGTCTGACCTGCTT	0.493000														307			36		0	0	0.017118	0	0
PCSK5	5125	broad.mit.edu	37	9	78907175	78907175	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr9:78907175G>A	uc004akc.2	+	24	3707	c.3169G>A	c.(3169-3171)Gct>Act	p.A1057T		NM_001190482	NP_001177411	Q92824	PCSK5_HUMAN	Homo sapiens proprotein convertase subtilisin/kexin type 5 (PCSK5), transcript variant 1, mRNA.	757					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	Golgi lumen|extracellular space|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TACATCTTGCGCTATGGGGTA	0.363000														100			10		0	0	0.020292	0	0
OLFM3	118427	broad.mit.edu	37	1	102270070	102270070	+	Silent	SNP	A	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:102270070A>G	uc001duf.2	-	5	1232	c.1161T>C	c.(1159-1161)acT>acC	p.T387T	OLFM3_uc001dug.2_Silent_p.T367T|OLFM3_uc001duh.2_Non-coding_Transcript|OLFM3_uc001dui.2_Non-coding_Transcript|OLFM3_uc001duj.2_Silent_p.T292T|OLFM3_uc001due.2_Non-coding_Transcript	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	Homo sapiens olfactomedin 3 (OLFM3), mRNA.	387	Olfactomedin-like.					extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TGGGGTAGCCAGTGCTCCAGC	0.478000														77			11		0	0	0.008291	0	0
ZNF22	7570	broad.mit.edu	37	10	45498982	45498982	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr10:45498982A>G	uc001jbw.3	+	1	409	c.166A>G	c.(166-168)Aaa>Gaa	p.K56E	C10orf25_uc001jbv.2_5'Flank|ZNF22_uc001jbx.1_Non-coding_Transcript|ZNF22_uc021ppo.1_Missense_Mutation_p.K56E	NM_006963	NP_008894	P17026	ZNF22_HUMAN	Homo sapiens zinc finger protein 22 (KOX 15) (ZNF22), mRNA.	56					odontogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|plasma membrane	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|lung(2)	8		Prostate(175;0.0352)|all_neural(218;0.202)				CAAACCCTATAAATGTACTGA	0.433000														55			9		0	0	0.006214	0	0
ZNF22	7570	broad.mit.edu	37	10	45498963	45498963	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr10:45498963C>G	uc001jbw.3	+	1	390	c.147C>G	c.(145-147)agC>agG	p.S49R	C10orf25_uc001jbv.2_5'Flank|ZNF22_uc001jbx.1_Non-coding_Transcript|ZNF22_uc021ppo.1_Missense_Mutation_p.S49R	NM_006963	NP_008894	P17026	ZNF22_HUMAN	Homo sapiens zinc finger protein 22 (KOX 15) (ZNF22), mRNA.	49					odontogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|plasma membrane	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|lung(2)	8		Prostate(175;0.0352)|all_neural(218;0.202)				TCAGAAGAAGCTTGGATGACA	0.438000														67			9		0	0	0.008291	0	0
ADCY8	114	broad.mit.edu	37	8	131916183	131916183	+	Silent	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr8:131916183G>A	uc003ytd.4	-	6	2002	c.1746C>T	c.(1744-1746)atC>atT	p.I582I	ADCY8_uc010mds.3_Silent_p.I582I	NM_001115	NP_001106	P40145	ADCY8_HUMAN	Homo sapiens adenylate cyclase 8 (brain) (ADCY8), mRNA.	582					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGTAAGTTTCGATATTATGCT	0.478000										HNSCC(32;0.087)				122			11		0	0	0.013537	0	0
LOC100509575	100509575	broad.mit.edu	37	X	47979536	47979536	+	RNA	SNP	C	T	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chrX:47979536C>T	uc022bvt.1	+	7		c.754C>T				NM_001205103		B7Z813	B7Z813_HUMAN	Homo sapiens putative protein SSX6-like (LOC100509575), mRNA.						regulation of transcription, DNA-dependent	intracellular	nucleic acid binding										TGACCTTTCACGAACGTGGGC	0.498000														19			5		0	0	0.021553	0	0
CCNB3	85417	broad.mit.edu	37	X	50094673	50094673	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chrX:50094673G>C	uc004dox.4	+	12	4457	c.4159G>C	c.(4159-4161)Gat>Cat	p.D1387H	CCNB3_uc004doy.3_Missense_Mutation_p.D1387H|CCNB3_uc004doz.3_Missense_Mutation_p.D283H|CCNB3_uc010njq.3_Missense_Mutation_p.D279H|CCNB3_uc004dpa.3_Missense_Mutation_p.D226H	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	Homo sapiens cyclin B3 (CCNB3), transcript variant 3, mRNA.	1387					cell division|meiosis|regulation of G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					TTTGAACTGTGATTGTGAGGC	0.458000														22			4		0	0	0.014758	0	0
PIGR	5284	broad.mit.edu	37	1	207110861	207110861	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:207110861G>C	uc001hez.3	-	3	808	c.624C>G	c.(622-624)aaC>aaG	p.N208K	PIGR_uc009xbz.3_Missense_Mutation_p.N208K	NM_002644	NP_002635	P01833	PIGR_HUMAN	Homo sapiens polymeric immunoglobulin receptor (PIGR), mRNA.	208	Ig-like V-type 2.			NQ -> DE (in Ref. 6; AA sequence and 7; AA sequence).		extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GCCTGAGTTGGTTGATGACAA	0.483000														51			4		0	0	0.009096	0	0
CFH	3075	broad.mit.edu	37	1	196884213	196884213	+	Silent	SNP	T	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:196884213T>A	uc001gtp.3	+	8	1622	c.1485T>A	c.(1483-1485)ggT>ggA	p.G495G	CFH_uc021pgt.1_Silent_p.G118G|CFH_uc009wyy.3_Silent_p.G494G|CFH_uc001gto.3_Silent_p.G248G	NM_001201550	NP_001188479	P08603	CFAH_HUMAN	Homo sapiens complement factor H-related 4 (CFHR4), transcript variant 1, mRNA.	847	Sushi 8.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						AACTTCAGGGTTCTAATTATG	0.398000														165			9		0	0	0.004482	0	0
HBD	3045	broad.mit.edu	37	11	5255363	5255363	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:5255363T>G	uc001maf.1	-	1	368	c.173A>C	c.(172-174)aAc>aCc	p.N58T		NM_000519	NP_000510	P02042	HBD_HUMAN	Homo sapiens hemoglobin, delta (HBD), mRNA.	58			N -> K (in Campania; dbSNP:rs35666685).		blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	16		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACCTTAGGGTTGCCCATAAC	0.527000														78			15		0	0	0.028581	0	0
INHBC	3626	broad.mit.edu	37	12	57828826	57828826	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:57828826G>A	uc001snv.1	+	0	284	c.157G>A	c.(157-159)Gac>Aac	p.D53N		NM_005538	NP_005529	P55103	INHBC_HUMAN	Homo sapiens inhibin, beta C (INHBC), mRNA.	53					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						AAGCATCTTGGACAAGCTGCA	0.632000														56			34		0	0	0.021022	0	0
TMEM74	157753	broad.mit.edu	37	8	109796516	109796516	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr8:109796516G>C	uc003ymy.1	-	1	917	c.812C>G	c.(811-813)tCt>tGt	p.S271C	TMEM74_uc003ymx.3_Intron|TMEM74_uc022azr.1_Missense_Mutation_p.S271C	NM_153015	NP_694560	Q96NL1	TMM74_HUMAN	Homo sapiens transmembrane protein 74 (TMEM74), mRNA.	271					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			GAGTTTTGCAGACTCTTTGGA	0.488000														43			5		0	0	0.014758	0	0
OR2J2	26707	broad.mit.edu	37	6	29141880	29141880	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr6:29141880C>G	uc011dlm.2	+	0	570	c.468C>G	c.(466-468)atC>atG	p.I156M		NM_030905	NP_112167	O76002	OR2J2_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily J, member 2 (OR2J2), mRNA.	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						GTTTTACTATCTCAGCACTTC	0.458000														219			15		0	0	0.006122	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72013863	72013863	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:72013863G>A	uc001swo.2	-	25	5251	c.4892C>T	c.(4891-4893)tCa>tTa	p.S1631L		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	Homo sapiens zinc finger, C3H1-type containing (ZFC3H1), mRNA.	1631					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						AATAGGACATGATTCCAATAA	0.353000														29			13		0	0	0.013537	0	0
GRIP1	23426	broad.mit.edu	37	12	66786136	66786136	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:66786136C>G	uc001stk.3	-	17	2501	c.2260G>C	c.(2260-2262)Gtg>Ctg	p.V754L	GRIP1_uc010sta.1_Missense_Mutation_p.V698L|GRIP1_uc001stj.3_Missense_Mutation_p.V536L|GRIP1_uc001stm.3_Missense_Mutation_p.V754L|GRIP1_uc001stl.1_Missense_Mutation_p.V646L	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	Homo sapiens glutamate receptor interacting protein 1 (GRIP1), transcript variant 1, mRNA.	806	PDZ 6.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CATGAATCCACAGCACTGTCC	0.547000														164			17		0	0	0.006122	0	0
KIAA1683	80726	broad.mit.edu	37	19	18377313	18377313	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr19:18377313A>G	uc010ebn.2	-	2	1253	c.1037T>C	c.(1036-1038)gTc>gCc	p.V346A	KIAA1683_uc002nin.2_Missense_Mutation_p.V346A|KIAA1683_uc010xqe.1_Missense_Mutation_p.V300A	NM_001145304	NP_001138776	Q9H0B3	K1683_HUMAN	Homo sapiens KIAA1683 (KIAA1683), transcript variant 1, mRNA.	346	Thr-rich.					mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						GGTCACGGAGACCACTGGATA	0.557000														81			7		0	0	0.003080	0	0
LUM	4060	broad.mit.edu	37	12	91502123	91502123	+	Silent	SNP	A	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:91502123A>G	uc001tbm.3	-	1	1023	c.634T>C	c.(634-636)Tta>Cta	p.L212L		NM_002345	NP_002336	P51884	LUM_HUMAN	Homo sapiens lumican (LUM), mRNA.	212					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						TTGTTGTCTAAGTAGAGAGTT	0.413000														76			5		0	0	0.014758	0	0
MYH15	22989	broad.mit.edu	37	3	108158593	108158593	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:108158593T>G	uc003dxa.1	-	24	3183	c.3126A>C	c.(3124-3126)caA>caC	p.Q1042H		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	Homo sapiens myosin, heavy chain 15 (MYH15), mRNA.	1042						myofibril|myosin filament	ATP binding|actin binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CCTCATCAACTTGCTGTTCCA	0.443000														111			12		0	0	0.020292	0	0
SHARPIN	81858	broad.mit.edu	37	8	145153831	145153831	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr8:145153831T>A	uc003zba.3	-	7	1598	c.1114A>T	c.(1114-1116)Agc>Tgc	p.S372C	SHARPIN_uc003zbb.3_Non-coding_Transcript	NM_030974	NP_112236	Q9H0F6	SHRPN_HUMAN	Homo sapiens SHANK-associated RH domain interactor (SHARPIN), transcript variant 1, mRNA.	372					negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	LUBAC complex|cytosol	polyubiquitin binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|lung(2)|ovary(2)	7	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTCTGGGTGCTACACATCTCA	0.632000														30			5		0	0	0.021553	0	0
VGF	7425	broad.mit.edu	37	7	100807585	100807585	+	Silent	SNP	C	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr7:100807585C>G	uc003uxx.4	-	1	758	c.540G>C	c.(538-540)acG>acC	p.T180T	VGF_uc022aiz.1_Silent_p.T180T	NM_003378	NP_003369	O15240	VGF_HUMAN	Homo sapiens VGF nerve growth factor inducible (VGF), mRNA.	180					response to cAMP	extracellular space|transport vesicle	growth factor activity	p.E179Q(1)		cervix(1)|large_intestine(1)|lung(4)|prostate(2)|skin(1)	9	Lung NSC(181;0.168)|all_lung(186;0.215)					CTGCTGCCGCCGTCTCCTGCT	0.667000														53			3		0	0	0.009096	0	0
HNRNPF	3185	broad.mit.edu	37	10	43883047	43883047	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr10:43883047C>T	uc009xmh.1	-	2	773	c.286G>A	c.(286-288)Gtg>Atg	p.V96M	HNRNPF_uc001jar.2_Missense_Mutation_p.V96M|HNRNPF_uc001jas.2_Missense_Mutation_p.V96M|HNRNPF_uc001jat.2_Missense_Mutation_p.V96M|HNRNPF_uc001jav.2_Missense_Mutation_p.V96M|HNRNPF_uc001jau.2_Missense_Mutation_p.V96M|HNRNPF_uc021ppg.1_Missense_Mutation_p.V96M|HNRNPF_uc010qfa.1_3'UTR	NM_001098208	NP_004957	P52597	HNRPF_HUMAN	Homo sapiens heterogeneous nuclear ribonucleoprotein F (HNRNPF), transcript variant 1, mRNA.	96					regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|urinary_tract(1)	19						TGCTTCAACACCCAATCCATC	0.498000														58			6		0	0	0.029380	0	0
MYLK3	91807	broad.mit.edu	37	16	46764535	46764535	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr16:46764535T>C	uc002eei.4	-	4	1654	c.1538A>G	c.(1537-1539)tAc>tGc	p.Y513C	MYLK3_uc010vge.2_Missense_Mutation_p.Y172C|MYLK3_uc002eej.1_Missense_Mutation_p.Y172C	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	Homo sapiens myosin light chain kinase 3 (MYLK3), mRNA.	513					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GCACACCTCGTAACCCGCAGA	0.612000														72			3		0	0	0.004672	0	0
OR4N3P	390539	broad.mit.edu	37	15	22413771	22413771	+	Silent	SNP	T	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr15:22413771T>C	uc001yuf.3	+	0	310	c.70T>C	c.(70-72)Ttg>Ctg	p.L24L	abParts_uc001yuj.2_Intron					Homo sapiens olfactory receptor, family 4, subfamily N, member 3 pseudogene (OR4N3P), non-coding RNA.																		GCTCTTTTTCTTGCACTTCCT	0.493000														179			7		0	0	0.006214	0	0
PEX7	5191	broad.mit.edu	37	6	137219309	137219309	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr6:137219309T>A	uc003qhd.3	+	8	935	c.833T>A	c.(832-834)cTt>cAt	p.L278H	PEX7_uc010kgx.3_Non-coding_Transcript	NM_000288	NP_000279	O00628	PEX7_HUMAN	Homo sapiens peroxisomal biogenesis factor 7 (PEX7), mRNA.	278					ether lipid biosynthetic process|protein import into peroxisome matrix	peroxisome	peroxisome matrix targeting signal-2 binding			lung(7)|prostate(1)	8	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000257)|OV - Ovarian serous cystadenocarcinoma(155;0.00492)		CCTGACTCTCTTCTTGAAACA	0.338000														52			4		0	0	0.014758	0	0
ARRDC1	92714	broad.mit.edu	37	9	140507428	140507428	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr9:140507428T>A	uc004cnp.2	+	1	273	c.199T>A	c.(199-201)Ttc>Atc	p.F67I	ARRDC1_uc004cns.3_Missense_Mutation_p.F67I|ARRDC1_uc004cnx.2_5'UTR			Q8N5I2	ARRD1_HUMAN	Homo sapiens arrestin domain containing 1 (ARRDC1), mRNA.	67										breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|urinary_tract(1)	13	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000273)|Epithelial(140;0.000464)		GGAGGGTTACTTCAACAGTTC	0.602000														23			3		0	0	0.009096	0	0
WSB1	26118	broad.mit.edu	37	17	25639344	25639344	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr17:25639344G>T	uc002gzd.1	+	8	1531	c.1215G>T	c.(1213-1215)caG>caT	p.Q405H	WSB1_uc002gze.1_Missense_Mutation_p.Q259H|WSB1_uc002gzf.1_Non-coding_Transcript	NM_015626	NP_056441	Q9Y6I7	WSB1_HUMAN	Homo sapiens WD repeat and SOCS box containing 1 (WSB1), transcript variant 1, mRNA.	405	SOCS box.				intracellular signal transduction	intracellular	protein binding			lung(3)	3	all_cancers(1;2e-13)|all_epithelial(1;4.8e-15)|Lung NSC(42;0.00152)		BRCA - Breast invasive adenocarcinoma(3;0.0152)	UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AAGAAGTTCAGGAGCTGCCGA	0.478000														339			24		6.07407e-21	6.64352e-21	0.034045	1	0
CMTM2	146225	broad.mit.edu	37	16	66613633	66613633	+	Silent	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr16:66613633G>A	uc002ept.3	+	0	283	c.123G>A	c.(121-123)gcG>gcA	p.A41A	CMTM2_uc010cdu.3_Silent_p.A41A	NM_144673	NP_653274	Q8TAZ6	CKLF2_HUMAN	Homo sapiens CKLF-like MARVEL transmembrane domain containing 2 (CMTM2), transcript variant 1, mRNA.	41					chemotaxis	extracellular space|integral to membrane	cytokine activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	17		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)		CTCAAAAGGCGGTGCAGGACC	0.622000														47			6		0	0	0.029380	0	0
DQ596604	0	broad.mit.edu	37	15	102312676	102312676	+	Splice_Site	SNP	T	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr15:102312676T>C	uc010utm.1	+	1		c.1_splice	c.e1-1		DQ578010_uc021szd.1_5'Flank|DQ599787_uc002ccq.3_5'Flank|DQ588124_uc010utn.2_5'Flank|DQ572823_uc021sze.1_5'Flank|DQ580168_uc002ccs.1_5'Flank|DQ601694_uc010uto.1_5'Flank|DQ582073_uc002cct.1_5'Flank|DQ571638_uc002ccu.3_5'Flank|DQ570882_uc002ccv.1_5'Flank|DQ593032_uc010utp.2_5'Flank|DQ589204_uc021szf.1_5'Flank					Homo sapiens piRNA piR-42886, complete sequence.																		AGGAGGTCCATAAGGCCACTC	0.562000														57			5		0	0	0.021553	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904125	21904125	+	RNA	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr17:21904125G>A	uc002gza.2	+	0		c.64G>A								Homo sapiens uncharacterized FLJ36000 (FLJ36000), non-coding RNA.																		ggagtcgcaaggggccgagca	0.697000														34			3		0	0	0.004672	0	0
SSX2IP	117178	broad.mit.edu	37	1	85136353	85136353	+	Silent	SNP	T	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:85136353T>C	uc001dki.3	-	3	515	c.189A>G	c.(187-189)gaA>gaG	p.E63E	SSX2IP_uc001dkf.3_Silent_p.E36E|SSX2IP_uc001dkh.3_Silent_p.E63E|SSX2IP_uc010orz.2_Silent_p.E36E|SSX2IP_uc001dkg.3_Non-coding_Transcript|SSX2IP_uc010osa.2_Silent_p.E36E|SSX2IP_uc001dkj.3_Silent_p.E63E|SSX2IP_uc009wci.3_Intron|SSX2IP_uc001dkk.1_Silent_p.E59E	NM_014021	NP_001159767	Q9Y2D8	ADIP_HUMAN	Homo sapiens synovial sarcoma, X breakpoint 2 interacting protein (SSX2IP), transcript variant 5, mRNA.	63					cell adhesion	nucleus|protein complex				endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|urinary_tract(1)	19				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		AGATACTCTGTTCAATATTAT	0.299000														71			8		0	0	0.003080	0	0
SLC17A6	57084	broad.mit.edu	37	11	22381014	22381014	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:22381014G>T	uc001mqk.3	+	3	927	c.514G>T	c.(514-516)Gca>Tca	p.A172S		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	Homo sapiens solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 (SLC17A6), mRNA.	172					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						AATTCCATCAGCAGCCAGAGT	0.398000														59			7		0.00307968	0.00320165	0.003080	1	0
RAB3IP	117177	broad.mit.edu	37	12	70178515	70178515	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:70178515G>C	uc001svp.3	+	3	1021	c.574G>C	c.(574-576)Gat>Cat	p.D192H	RAB3IP_uc021rao.1_Missense_Mutation_p.D176H|RAB3IP_uc001svm.3_Missense_Mutation_p.D176H|RAB3IP_uc001svn.3_Missense_Mutation_p.D176H|RAB3IP_uc001svo.3_Non-coding_Transcript|RAB3IP_uc001svq.3_Missense_Mutation_p.D192H|RAB3IP_uc001svs.3_Non-coding_Transcript|RAB3IP_uc001svt.3_5'UTR	NM_175623	NP_001019818	Q96QF0	RAB3I_HUMAN	Homo sapiens RAB3A interacting protein (rabin3) (RAB3IP), transcript variant alpha 2, mRNA.	192					Golgi to plasma membrane transport|cilium assembly|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			GAAGTTAAAAGATGAAGAATG	0.323000														133			4		0	0	0.009096	0	0
NOL4	8715	broad.mit.edu	37	18	31537451	31537451	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr18:31537451A>C	uc010dmi.3	-	7	1565	c.1267T>G	c.(1267-1269)Ttg>Gtg	p.L423V	NOL4_uc010xbs.2_Missense_Mutation_p.L138V|NOL4_uc002kxr.4_Intron|NOL4_uc010xbt.2_Missense_Mutation_p.L349V|NOL4_uc010dmh.3_Intron|NOL4_uc010xbu.2_Intron|NOL4_uc002kxt.4_Intron|NOL4_uc010xbv.1_Intron	NM_003787	NP_001185478	O94818	NOL4_HUMAN	Homo sapiens nucleolar protein 4 (NOL4), transcript variant 1, mRNA.	423						nucleolus	RNA binding	p.L423L(2)		NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						ATTCGGTCCAAGTTTTCATCT	0.493000														26			7		0	0	0.029380	0	0
TFEB	7942	broad.mit.edu	37	6	41652468	41652468	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr6:41652468C>T	uc021yzl.1	-	7	1502	c.1501G>A	c.(1501-1503)Gac>Aac	p.D501N	TFEB_uc003oqs.1_Missense_Mutation_p.D434N|TFEB_uc003oqt.1_Missense_Mutation_p.D434N|TFEB_uc003oqu.1_Missense_Mutation_p.D434N|TFEB_uc003oqr.1_Missense_Mutation_p.D349N	NM_007162	NP_009093	P19484	TFEB_HUMAN	Homo sapiens transcription factor EB (TFEB), transcript variant 1, mRNA.	434					embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	11	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			AGCATGAGGTCCAGATCCTTC	0.677000			T	ALPHA	renal (childhood epithelioid)									71			5		0	0	0.014758	0	0
USP44	84101	broad.mit.edu	37	12	95926931	95926931	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr12:95926931G>C	uc001teg.3	-	1	1246	c.1102C>G	c.(1102-1104)Ctt>Gtt	p.L368V	USP44_uc001teh.3_Missense_Mutation_p.L368V|USP44_uc009zte.3_Missense_Mutation_p.L365V	NM_001042403	NP_115523	Q9H0E7	UBP44_HUMAN	Homo sapiens ubiquitin specific peptidase 44 (USP44), transcript variant 2, mRNA.	368					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(5)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	36						GGCTGAATAAGTTCCATCTTT	0.418000														79			5		0	0	0.014758	0	0
NANOS3	342977	broad.mit.edu	37	19	13988290	13988290	+	Silent	SNP	G	T	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr19:13988290G>T	uc002mxj.4	+	0	228	c.228G>T	c.(226-228)ctG>ctT	p.L76L		NM_001098622	NP_001092092	P60323	NANO3_HUMAN	Homo sapiens nanos homolog 3 (Drosophila) (NANOS3), mRNA.	57					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			breast(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	7			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			CCGAACGCCTGTGCTCTTTCT	0.657000														31			7		0.00307968	0.00320165	0.003080	1	0
ADAMTS9	56999	broad.mit.edu	37	3	64589985	64589985	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:64589985T>C	uc003dmg.3	-	23	3529	c.3497A>G	c.(3496-3498)cAt>cGt	p.H1166R	ADAMTS9_uc011bfo.2_Missense_Mutation_p.H1138R|ADAMTS9_uc003dmh.1_Missense_Mutation_p.H995R|ADAMTS9_uc011bfp.1_Missense_Mutation_p.H77R	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), mRNA.	1166	TSP type-1 6.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TGGGGGAGGATGACATGATGG	0.473000														628			29		0	0	0.017118	0	0
TCRBV14S1	0	broad.mit.edu	37	7	142423696	142423696	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr7:142423696T>G	uc010lol.1	+	1	385	c.352T>G	c.(352-354)Ttg>Gtg	p.L118V	TRBV5-1_uc011krr.1_Intron|TCRBV2S1_uc003vzp.2_Intron|TCRBV3S1_uc011ksh.2_Intron|TCRBV3S1_uc003vzw.2_Intron|TCRBV3S1_uc011ksi.2_Intron|TCRBV3S1_uc010loj.2_Intron|TRBV23-1_uc022ans.1_Intron|TCRBV14S1_uc011ksj.1_Non-coding_Transcript					SubName: Full=V_segment translation product; Flags: Fragment;																		ATCCACAGTGTTGCACAGCCA	0.527000														28			3		0	0	0.004672	0	0
HLA-DRA	3122	broad.mit.edu	37	6	32411551	32411551	+	Missense_Mutation	SNP	C	T	T	rs58547911		TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr6:32411551C>T	uc003obh.3	+	3	738	c.629C>T	c.(628-630)cCt>cTt	p.P210L	HLA-DRA_uc003obi.3_Missense_Mutation_p.P185L	NM_019111	NP_061984	P01903	DRA_HUMAN	Homo sapiens major histocompatibility complex, class II, DR alpha (HLA-DRA), mRNA.	210	Connecting peptide.				T cell costimulation|T cell receptor signaling pathway|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway	Golgi apparatus|MHC class II protein complex|endoplasmic reticulum membrane|integral to plasma membrane|late endosome membrane|lysosomal membrane	MHC class II receptor activity	p.P210H(2)		NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	19						GCTCCAAGCCCTCTCCCAGAG	0.488000									T-cell Lymphoma, (Cutaneous) , Familial Clustering of;Kaposi Sarcoma, Familial Clustering of					163			12		0	0	0.020292	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156632186	156632186	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr4:156632186T>C	uc003iov.3	+	6	1405	c.869T>C	c.(868-870)tTc>tCc	p.F290S	GUCY1A3_uc003iou.2_Missense_Mutation_p.F290S|GUCY1A3_uc010iqc.2_Missense_Mutation_p.F290S|GUCY1A3_uc010iqd.3_Missense_Mutation_p.F289S|GUCY1A3_uc003iow.3_Missense_Mutation_p.F290S|GUCY1A3_uc003iox.3_Missense_Mutation_p.F290S|GUCY1A3_uc010iqe.3_Missense_Mutation_p.F55S|GUCY1A3_uc003ioy.3_Missense_Mutation_p.F290S|GUCY1A3_uc003ioz.3_Missense_Mutation_p.F55S|GUCY1A3_uc003ipa.3_Intron|GUCY1A3_uc003ipb.3_Missense_Mutation_p.F290S	NM_000856	NP_001124157	Q02108	GCYA3_HUMAN	Homo sapiens guanylate cyclase 1, soluble, alpha 3 (GUCY1A3), transcript variant 1, mRNA.	290					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CCATTCCATTTCATGTTTGAC	0.443000														54			3		0	0	0.004672	0	0
PCDH15	65217	broad.mit.edu	37	10	55587280	55587280	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr10:55587280G>A	uc010qhy.1	-	32	4650	c.4255C>T	c.(4255-4257)Cga>Tga	p.R1419*	PCDH15_uc010qhq.2_Nonsense_Mutation_p.R1419*|PCDH15_uc010qhr.2_Nonsense_Mutation_p.R1414*|PCDH15_uc021pqv.1_Nonsense_Mutation_p.R1414*|PCDH15_uc021pqw.1_Nonsense_Mutation_p.R1426*|PCDH15_uc010qht.2_Nonsense_Mutation_p.R1421*|PCDH15_uc021pqx.1_Nonsense_Mutation_p.R1414*|PCDH15_uc001jjv.1_Intron|PCDH15_uc021pqy.1_Nonsense_Mutation_p.R1414*|PCDH15_uc021pqz.1_Nonsense_Mutation_p.R1389*|PCDH15_uc010qhv.1_Nonsense_Mutation_p.R1411*|PCDH15_uc010qhw.1_Nonsense_Mutation_p.R1374*|PCDH15_uc010qhx.1_Nonsense_Mutation_p.R1343*|PCDH15_uc010qhz.1_Nonsense_Mutation_p.R1414*|PCDH15_uc010qia.1_Nonsense_Mutation_p.R1392*|PCDH15_uc001jju.1_Nonsense_Mutation_p.R1414*|PCDH15_uc010qib.1_Nonsense_Mutation_p.R1389*	NM_001142763	NP_001136235	Q96QU1	PCD15_HUMAN	Homo sapiens protocadherin-related 15 (PCDH15), transcript variant A, mRNA.	1414					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GCCTGAATTCGTGCAGTCTTT	0.537000										HNSCC(58;0.16)				58			6		0	0	0.003080	0	0
TMEM88	92162	broad.mit.edu	37	17	7758463	7758463	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr17:7758463G>C	uc002giy.3	+	0	80	c.71G>C	c.(70-72)tGt>tCt	p.C24S	CYB5D1_uc002gjb.4_5'Flank	NM_203411	NP_981956	Q6PEY1	TMM88_HUMAN	Homo sapiens transmembrane protein 88 (TMEM88), mRNA.	24						integral to membrane				lung(1)	1		all_cancers(10;0.00528)|Prostate(122;0.202)				CCCCTGGACTGTTGGGCCTGC	0.672000														21			5		0	0	0.021553	0	0
LRRN4	164312	broad.mit.edu	37	20	6022584	6022584	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr20:6022584G>C	uc002wmo.2	-	4	1531	c.1307C>G	c.(1306-1308)tCt>tGt	p.S436C		NM_152611	NP_689824	Q8WUT4	LRRN4_HUMAN	Homo sapiens leucine rich repeat neuronal 4 (LRRN4), mRNA.	436						integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						ACCTGCTACAGAGTTGGTCGT	0.637000														72			6		0	0	0.029380	0	0
MTRR	4552	broad.mit.edu	37	5	7873569	7873569	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr5:7873569G>C	uc003jed.3	+	2	324	c.294G>C	c.(292-294)aaG>aaC	p.K98N	MTRR_uc010itn.1_Intron|MTRR_uc003jee.4_Missense_Mutation_p.K71N|MTRR_uc003jef.4_Non-coding_Transcript|MTRR_uc003jeg.4_Intron|MTRR_uc010ito.3_Non-coding_Transcript	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	Homo sapiens 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR), transcript variant 2, mRNA.	98	Flavodoxin-like.				methionine biosynthetic process	cytosol	FMN binding|NADP binding|[methionine synthase] reductase activity|flavin adenine dinucleotide binding|iron ion binding			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CAGCCCGCAAGTTTGTTAAGG	0.463000														89			4		0	0	0.009096	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39140536	39140536	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr9:39140536A>T	uc004abi.3	-	11	2095	c.1856T>A	c.(1855-1857)cTt>cAt	p.L619H	CNTNAP3_uc004abj.3_Missense_Mutation_p.L619H|CNTNAP3_uc011lqr.2_Non-coding_Transcript|CNTNAP3_uc004abk.1_Missense_Mutation_p.L619H|CNTNAP3_uc011lqs.1_Missense_Mutation_p.L526H	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	Homo sapiens contactin associated protein-like 3 (CNTNAP3), mRNA.	619	Fibrinogen C-terminal.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GCAGTACACAAGAAATGGTCC	0.438000														61			6		0	0	0.029380	0	0
ATG4A	115201	broad.mit.edu	37	X	107381181	107381181	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chrX:107381181G>A	uc004enr.3	+	7	853	c.695G>A	c.(694-696)gGc>gAc	p.G232D	ATG4A_uc004ens.3_Missense_Mutation_p.G148D|ATG4A_uc011msl.2_Intron|ATG4A_uc010npi.3_Non-coding_Transcript|ATG4A_uc004ent.3_Intron	NM_052936	NP_443168	Q8WYN0	ATG4A_HUMAN	Homo sapiens ATG4 autophagy related 4 homolog A (S. cerevisiae) (ATG4A), transcript variant 1, mRNA.	232					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity	p.G232D(3)		endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)	11						CTTCGCCTGGGCATAAACCAA	0.522000														130			4		0	0	0.014758	0	0
MUC5B	727897	broad.mit.edu	37	11	1264737	1264737	+	Silent	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:1264737G>A	uc001lta.3	+	30	6686	c.6627G>A	c.(6625-6627)acG>acA	p.T2209T		NM_002458	NP_002449	Q9HC84	MUC5B_HUMAN	Homo sapiens mucin 5B, oligomeric mucus/gel-forming (MUC5B), mRNA.	2209	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GTCCCCACACGGTGCGCACAG	0.662000														46			18		0	0	0.016522	0	0
SERPINI1	5274	broad.mit.edu	37	3	167507139	167507139	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:167507139T>G	uc003ffa.4	+	1	421	c.223T>G	c.(223-225)Tca>Gca	p.S75A	SERPINI1_uc003ffb.4_Missense_Mutation_p.S75A	NM_001122752	NP_005016	Q99574	NEUS_HUMAN	Homo sapiens serpin peptidase inhibitor, clade I (neuroserpin), member 1 (SERPINI1), transcript variant 2, mRNA.	75					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(7)|skin(2)	20						AATCCGCCACTCAATGGGATA	0.383000														29			8		0	0	0.006214	0	0
PHF21A	51317	broad.mit.edu	37	11	46001496	46001496	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:46001496G>A	uc001ncc.4	-	5	799	c.175C>T	c.(175-177)Cgg>Tgg	p.R59W	PHF21A_uc001ncb.4_Missense_Mutation_p.R59W|PHF21A_uc009ykx.3_Missense_Mutation_p.R59W|PHF21A_uc001nce.2_Missense_Mutation_p.R59W	NM_001101802	NP_001095272	Q96BD5	PF21A_HUMAN	Homo sapiens PHD finger protein 21A (PHF21A), transcript variant 1, mRNA.	59	Gln-rich.				blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(10)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	29						AGGTTCTTCCGTAGCTGTTCA	0.383000														54			4		0	0	0.009096	0	0
NUP205	23165	broad.mit.edu	37	7	135263592	135263592	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr7:135263592G>A	uc003vsw.3	+	6	1002	c.971G>A	c.(970-972)gGg>gAg	p.G324E	NUP205_uc011kqa.1_Non-coding_Transcript	NM_015135	NP_055950	Q92621	NU205_HUMAN	Homo sapiens nucleoporin 205kDa (NUP205), mRNA.	324					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						AAACTGCCTGGGCTCCAAGCC	0.443000														73			5		0	0	0.014758	0	0
AKAP6	9472	broad.mit.edu	37	14	33292622	33292622	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr14:33292622A>C	uc001wrq.3	+	12	5773	c.5603A>C	c.(5602-5604)cAt>cCt	p.H1868P		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	Homo sapiens A kinase (PRKA) anchor protein 6 (AKAP6), mRNA.	1868					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AATTCATCTCATACCCATGAG	0.358000														30			4		0	0	0.009096	0	0
ELTD1	64123	broad.mit.edu	37	1	79383605	79383605	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr1:79383605T>C	uc001diq.4	-	10	1748	c.1592A>G	c.(1591-1593)aAg>aGg	p.K531R		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	Homo sapiens EGF, latrophilin and seven transmembrane domain containing 1 (ELTD1), mRNA.	531					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		ATAAAAATTCTTGTGCAAAAA	0.393000														102			10		0	0	0.006214	0	0
SPDYE5	442590	broad.mit.edu	37	7	75130883	75130883	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr7:75130883G>A	uc011kfy.2	+	5	894	c.758G>A	c.(757-759)cGt>cAt	p.R253H	DQ601342_uc022agh.1_5'Flank	NM_001099435	NP_001092905	A6NIY4	SPDE5_HUMAN	Homo sapiens speedy homolog E5 (Xenopus laevis) (SPDYE5), mRNA.	253	Arg-rich.																CAGTTAGGCCGTTCCATGAAC	0.592000														305			5		0	0	0.014758	0	0
OR5K4	403278	broad.mit.edu	37	3	98072851	98072851	+	Missense_Mutation	SNP	G	A	A	rs139874815	byFrequency	TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr3:98072851G>A	uc011bgv.2	+	0	154	c.154G>A	c.(154-156)Gag>Aag	p.E52K		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily K, member 4 (OR5K4), mRNA.	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	21						AATTTATGTAGAGCGTCGTCT	0.463000														227			17		0	0	0.028581	0	0
HNF4G	3174	broad.mit.edu	37	8	76465282	76465282	+	Silent	SNP	A	C	C			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr8:76465282A>C	uc003yaq.3	+	5	624	c.354A>C	c.(352-354)tcA>tcC	p.S118S	HNF4G_uc003yar.3_Silent_p.S155S	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	Homo sapiens hepatocyte nuclear factor 4, gamma (HNF4G), mRNA.	118					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			ACTAGATCTCAGTCTCAAGCC	0.353000														19			3		0	0	0.004672	0	0
KRTAP5-1	387264	broad.mit.edu	37	11	1605880	1605882	+	In_Frame_Del	DEL	GCC	-	-			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chr11:1605880_1605882delGCC	uc001ltu.1	-	0	632_634	c.598_600delGGC	c.(598-600)ggcdel	p.G200del	MOB2_uc001ltq.2_Intron|LOC338651_uc009ycx.1_Intron|LOC338651_uc001ltt.1_Intron	NM_001005922	NP_001005922	Q6L8H4	KRA51_HUMAN	Homo sapiens keratin associated protein 5-1 (KRTAP5-1), mRNA.	200	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(3)|kidney(1)|lung(9)|skin(2)|upper_aerodigestive_tract(1)	16		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGCCCCCACAGCCGGAGCCACAA	0.665													---	111	---	---	11	---					
GAGE2B	645037	broad.mit.edu	37	X	49208295	49208296	+	In_Frame_Ins	INS	-	TAT	TAT			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chrX:49208295_49208296insTAT	uc004dnv.4	+	1	140_141	c.24_25insTAT	c.(22-27)insTAT	p.9_10insY	GAGE2B_uc004dnl.4_Intron|GAGE2B_uc022bwc.1_Intron|GAGE2B_uc011mne.2_Intron|GAGE2B_uc004dnn.4_Intron|GAGE2B_uc011mnf.2_Intron|GAGE2B_uc004dnq.4_Intron|GAGE2B_uc004dnr.4_Intron|GAGE2B_uc004dnk.4_Intron|GAGE2B_uc004dno.4_Intron|GAGE2B_uc004dnp.4_Intron|GAGE2B_uc010njc.3_In_Frame_Ins_p.9_10insY|GAGE2B_uc004dnt.4_In_Frame_Ins_p.9_10insY|GAGE2B_uc004dnu.4_In_Frame_Ins_p.9_10insY	NM_001127212	NP_001091881			Homo sapiens G antigen 2A (GAGE2A), mRNA.																		GAAGATCGACCTATCGGCCTAG	0.465													---	10	---	---	8	---					
PLP1	5354	broad.mit.edu	37	X	103041638	103041639	+	Frame_Shift_Ins	INS	-	TA	TA			TCGA-D3-A3BZ-06A-12D-A196-08	TCGA-D3-A3BZ-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9ca03fc4-5f10-420a-8260-4af6e9650b86	e5d30ad9-ea36-4409-9fda-bb52ab23603a	g.chrX:103041638_103041639insTA	uc010nov.3	+	3	716_717	c.436_437insTA	c.(436-438)ctafs	p.L146fs	RAB9B_uc004eli.2_Intron|PLP1_uc004elk.3_Frame_Shift_Ins_p.L146fs|PLP1_uc004elj.3_Intron|PLP1_uc011msf.2_Frame_Shift_Ins_p.L91fs|PLP1_uc010now.1_Frame_Shift_Ins_p.L150fs|PLP1_uc010nox.3_Frame_Shift_Ins_p.L100fs	NM_001128834	NP_001122306	P60201	MYPR_HUMAN	Homo sapiens proteolipid protein 1 (PLP1), transcript variant 3, mRNA.	146			Missing (in HLD1).		cell death|synaptic transmission	integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	17						GGGAAAATGGCTAGGACATCCC	0.564													---	77	---	---	26	---