Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KLK8	11202	broad.mit.edu	37	19	51499342	51499342	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:51499342G>C	uc002puq.1	-	5	1077	c.891C>G	c.(889-891)atC>atG	p.I297M	KLK8_uc002pur.1_Missense_Mutation_p.I252M|KLK8_uc002pus.1_Missense_Mutation_p.I111M|KLK8_uc002put.1_3'UTR|KLK8_uc002puu.1_Missense_Mutation_p.I252M|KLK8_uc002puv.1_Non-coding_Transcript	NM_144505	NP_653088	O60259	KLK8_HUMAN	Homo sapiens kallikrein-related peptidase 8 (KLK8), transcript variant 2, mRNA.	252					cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		TGATCTTCTTGATCCAGTCCA	0.522000														105			23		0	0	0.003954	0	0
KLK8	11202	broad.mit.edu	37	19	51499264	51499264	+	Splice_Site	SNP	G	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:51499264G>A	uc002puq.1	-	6	1155	c.969_splice	c.e6+1		KLK8_uc002pur.1_Splice_Site|KLK8_uc002pus.1_Splice_Site|KLK8_uc002put.1_Splice_Site|KLK8_uc002puu.1_Splice_Site|KLK8_uc002puv.1_Splice_Site	NM_144505	NP_653088	O60259	KLK8_HUMAN	Homo sapiens kallikrein-related peptidase 8 (KLK8), transcript variant 2, mRNA.						cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		GACAGGCAAGGAACCAGAGAG	0.522000														86			32		0	0	0.002836	0	0
FAT4	79633	broad.mit.edu	37	4	126239466	126239466	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr4:126239466C>G	uc003ifj.4	+	0	1900	c.1900C>G	c.(1900-1902)Ctg>Gtg	p.L634V		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	Homo sapiens FAT tumor suppressor homolog 4 (Drosophila) (FAT4), mRNA.	634	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GTCCTTCCGTCTGGATCCTGT	0.557000														21			9		0	0	0.004482	0	0
WBP11	51729	broad.mit.edu	37	12	14947999	14947999	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr12:14947999C>T	uc001rci.3	-	5	588	c.427G>A	c.(427-429)Gat>Aat	p.D143N		NM_016312	NP_057396	Q9Y2W2	WBP11_HUMAN	Homo sapiens WW domain binding protein 11 (WBP11), mRNA.	143	Pro-rich.				RNA splicing|mRNA processing|rRNA processing	cytoplasm	WW domain binding|single-stranded DNA binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						TGTGGCATATCTGGCAAAGGA	0.428000														220			19		0	0	0.006122	0	0
NDST1	3340	broad.mit.edu	37	5	149900988	149900988	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr5:149900988G>T	uc003lsk.4	+	1	674	c.172G>T	c.(172-174)Gac>Tac	p.D58Y	NDST1_uc011dcj.2_Missense_Mutation_p.D58Y|NDST1_uc003lsl.3_Missense_Mutation_p.D58Y	NM_001543	NP_001534	P52848	NDST1_HUMAN	Homo sapiens N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (NDST1), mRNA.	58	Heparan sulfate N-deacetylase 1.				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	34		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGACTGCGGGGACCCGCCGCC	0.652000														40			12		5.50884e-06	7.24718e-05	0.001368	1	0
CYP4Z2P	163720	broad.mit.edu	37	1	47325354	47325354	+	RNA	SNP	G	A	A	rs4660360	by1000genomes	TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr1:47325354G>A	uc001cqo.1	-	8		c.1214C>T								Homo sapiens cytochrome P450, family 4, subfamily Z, polypeptide 2 pseudogene (CYP4Z2P), non-coding RNA.																		CATCTGGAAAGGTAATGGGTT	0.438000														66			7		0	0	0.000673	0	0
KCTD20	222658	broad.mit.edu	37	6	36446928	36446928	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr6:36446928C>A	uc003ome.3	+	3	856	c.465C>A	c.(463-465)ttC>ttA	p.F155L	KCTD20_uc011dtn.2_5'UTR|KCTD20_uc010jwk.3_Intron|KCTD20_uc011dto.2_Intron|KCTD20_uc011dtm.2_Missense_Mutation_p.F10L	NM_173562	NP_775833	Q7Z5Y7	KCD20_HUMAN	Homo sapiens potassium channel tetramerisation domain containing 20 (KCTD20), mRNA.	155	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|skin(1)	15						AGTACAACTTCACTCGGCCCA	0.433000														41			22		7.33532e-06	9.44024e-05	0.003954	1	0
ZNF45	7596	broad.mit.edu	37	19	44423036	44423036	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:44423036C>G	uc002oxu.2	-	2	320	c.221G>C	c.(220-222)aGa>aCa	p.R74T	ZNF45_uc002oxw.2_Missense_Mutation_p.R74T	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	Homo sapiens zinc finger protein 45 (ZNF45), mRNA.	74	KRAB.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.Q73K(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						GGAGTTATCTCTCTGGGTTGC	0.493000														36			11		0	0	0.001855	0	0
RPL13AP6	644511	broad.mit.edu	37	10	112696573	112696573	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr10:112696573T>C	uc010qrh.1	-	0	441	c.419A>G	c.(418-420)cAc>cGc	p.H140R	SHOC2_uc001kzl.4_Intron|SHOC2_uc009xxx.3_Intron|SHOC2_uc010qrg.2_Intron					Homo sapiens ribosomal protein L13a pseudogene 6 (RPL13AP6), non-coding RNA.									p.H140R(2)									GTGAGCCAGGTGCCCCAGATA	0.537000														0			2		0	0	0.004672	0	0
DSCAM	1826	broad.mit.edu	37	21	41455872	41455872	+	Silent	SNP	A	C	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr21:41455872A>C	uc002yyq.1	-	23	4646	c.4194T>G	c.(4192-4194)tcT>tcG	p.S1398S	DSCAM_uc002yyr.1_Non-coding_Transcript	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Homo sapiens Down syndrome cell adhesion molecule (DSCAM), transcript variant 1, mRNA.	1398	Fibronectin type-III 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CAGGGAGCCAAGAAAGGGTGA	0.443000														35			9		0	0	0.000673	0	0
PDE2A	5138	broad.mit.edu	37	11	72293497	72293497	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr11:72293497G>C	uc010rrc.2	-	20	2088	c.1842C>G	c.(1840-1842)gaC>gaG	p.D614E	PDE2A_uc001oso.3_Missense_Mutation_p.D593E|PDE2A_uc010rra.2_Missense_Mutation_p.D607E|PDE2A_uc001osn.3_Missense_Mutation_p.D358E|PDE2A_uc010rrb.2_Missense_Mutation_p.D605E|PDE2A_uc010rrd.2_Missense_Mutation_p.D499E	NM_002599	NP_002590	O00408	PDE2A_HUMAN	Homo sapiens phosphodiesterase 2A, cGMP-stimulated (PDE2A), transcript variant 1, mRNA.	614					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	CCATGGACGTGTCATCCTCGG	0.512000														129			31		0	0	0.002096	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44218202	44218202	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr6:44218202A>G	uc003oxa.1	+	5	907	c.823A>G	c.(823-825)Aaa>Gaa	p.K275E	HSP90AB1_uc011dvr.1_Missense_Mutation_p.K265E|HSP90AB1_uc003oxb.1_Missense_Mutation_p.K275E|HSP90AB1_uc011dvs.1_Missense_Mutation_p.K95E|HSP90AB1_uc003oxc.1_5'UTR	NM_007355	NP_031381	P08238	HS90B_HUMAN	Homo sapiens heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1), mRNA.	275					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|TPR domain binding|nitric-oxide synthase regulator activity|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			gatcaaagagaaATACATTGA	0.403000														34			8		0	0	0.003080	0	0
ARHGAP10	79658	broad.mit.edu	37	4	148944547	148944547	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr4:148944547G>A	uc003ilf.3	+	18	1850	c.1850G>A	c.(1849-1851)tGt>tAt	p.C617Y	ARHGAP10_uc003ilg.3_Missense_Mutation_p.C266Y|ARHGAP10_uc003ilh.3_Missense_Mutation_p.C198Y|ARHGAP10_uc003ili.3_Missense_Mutation_p.C50Y	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Homo sapiens Rho GTPase activating protein 10 (ARHGAP10), mRNA.	617					apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	SH3 domain binding|cytoskeletal adaptor activity			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		TACAATCTTTGTCTGGAGCTG	0.507000														30			13		0	0	0.003163	0	0
EIF3G	8666	broad.mit.edu	37	19	10226237	10226237	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:10226237G>A	uc002mnd.3	-	9	929	c.865C>T	c.(865-867)Cgc>Tgc	p.R289C		NM_003755	NP_003746	O75821	EIF3G_HUMAN	Homo sapiens eukaryotic translation initiation factor 3, subunit G (EIF3G), mRNA.	289	RRM.					cytosol|eukaryotic translation initiation factor 3 complex|nucleus|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity			central_nervous_system(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(20;3.53e-09)|Epithelial(33;4.91e-06)|all cancers(31;1.1e-05)			TCCTCGCGGCGGTGGAAGCTG	0.642000														39			11		0	0	0.000978	0	0
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	T	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr13:115047559C>T	uc001vup.3	+	1	327	c.271C>T	c.(271-273)Ctg>Ttg	p.L91L	UPF3A_uc010tkn.2_Silent_p.L91L|UPF3A_uc001vuq.3_Silent_p.L91L|UPF3A_uc001vur.3_Non-coding_Transcript	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	Homo sapiens UPF3 regulator of nonsense transcripts homolog A (yeast) (UPF3A), transcript variant 1, mRNA.	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	RNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding	p.L91L(16)		autonomic_ganglia(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	16	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731000														5			5		0	0	0.000602	0	0
KLK8	11202	broad.mit.edu	37	19	51499375	51499375	+	Silent	SNP	G	C	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:51499375G>C	uc002puq.1	-	5	1044	c.858C>G	c.(856-858)gtC>gtG	p.V286V	KLK8_uc002pur.1_Silent_p.V241V|KLK8_uc002pus.1_Silent_p.V100V|KLK8_uc002put.1_3'UTR|KLK8_uc002puu.1_Silent_p.V241V|KLK8_uc002puv.1_Non-coding_Transcript	NM_144505	NP_653088	O60259	KLK8_HUMAN	Homo sapiens kallikrein-related peptidase 8 (KLK8), transcript variant 2, mRNA.	241					cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity	p.V286I(1)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		TGTTGGTATAGACGCCAGGTT	0.537000														74			20		0	0	0.001882	0	0
KLK8	11202	broad.mit.edu	37	19	51499431	51499431	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:51499431G>A	uc002puq.1	-	5	988	c.802C>T	c.(802-804)Cag>Tag	p.Q268*	KLK8_uc002pur.1_Nonsense_Mutation_p.Q223*|KLK8_uc002pus.1_Nonsense_Mutation_p.Q82*|KLK8_uc002put.1_3'UTR|KLK8_uc002puu.1_Nonsense_Mutation_p.Q223*|KLK8_uc002puv.1_Non-coding_Transcript	NM_144505	NP_653088	O60259	KLK8_HUMAN	Homo sapiens kallikrein-related peptidase 8 (KLK8), transcript variant 2, mRNA.	223					cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		GTGATGCCCTGGAGTGCACCA	0.562000														53			13		0	0	0.002450	0	0
LOC220729	220729	broad.mit.edu	37	3	197348646	197348646	+	RNA	SNP	T	C	C	rs138265355	by1000genomes	TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr3:197348646T>C	uc011bug.2	-	3		c.445A>G			LOC220729_uc003fxy.3_Non-coding_Transcript|LOC220729_uc010iao.2_Intron					Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) pseudogene (LOC220729), non-coding RNA.																		TGGGCCTGCCTGCCCTTTCCA	0.532000														48			5		0	0	0.001168	0	0
ZMYND10	51364	broad.mit.edu	37	3	50379244	50379244	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr3:50379244C>G	uc003dag.1	-	9	1264	c.1118G>C	c.(1117-1119)cGa>cCa	p.R373P	RASSF1_uc003dad.1_5'Flank|RASSF1_uc003dae.1_5'Flank|RASSF1_uc003daf.1_5'Flank|RASSF1_uc010hlk.1_5'Flank|RASSF1_uc011bdq.1_5'Flank|ZMYND10_uc010hll.1_Missense_Mutation_p.R368P	NM_015896	NP_056980	O75800	ZMY10_HUMAN	Homo sapiens zinc finger, MYND-type containing 10 (ZMYND10), mRNA.	373						cytoplasm	protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|urinary_tract(2)	14				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GCCTTACCTTCGCGCCTGCAG	0.632000										TSP Lung(30;0.18)				24			10		0	0	0.000673	0	0
VRK3	51231	broad.mit.edu	37	19	50496177	50496177	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:50496177C>G	uc002prg.2	-	9	1001	c.903G>C	c.(901-903)gaG>gaC	p.E301D	VRK3_uc002prh.1_Missense_Mutation_p.E301D|VRK3_uc002pri.1_Missense_Mutation_p.E251D|VRK3_uc010ens.2_Missense_Mutation_p.E301D|VRK3_uc010ybl.1_Missense_Mutation_p.E251D|VRK3_uc010ybm.1_Missense_Mutation_p.E70D|VRK3_uc002prk.2_Missense_Mutation_p.E301D|VRK3_uc010ent.2_Missense_Mutation_p.E57D|VRK3_uc002prl.3_Missense_Mutation_p.E301D|VRK3_uc010ybn.1_Missense_Mutation_p.S279T	NM_016440	NP_057524	Q8IV63	VRK3_HUMAN	Homo sapiens vaccinia related kinase 3 (VRK3), transcript variant 1, mRNA.	301	Protein kinase.					nucleus	ATP binding|protein kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)|stomach(2)|urinary_tract(1)	23		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		CATGAACATACTCATTCTCAT	0.512000														73			21		0	0	0.001523	0	0
KRTAP1-3	81850	broad.mit.edu	37	17	39191032	39191032	+	Silent	SNP	G	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr17:39191032G>A	uc002hvv.3	-	0	76	c.42C>T	c.(40-42)tgC>tgT	p.C14C		NM_030966	NP_112228	Q8IUG1	KRA13_HUMAN	Homo sapiens keratin associated protein 1-3 (KRTAP1-3), mRNA.	14						extracellular region|keratin filament	structural constituent of epidermis			cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(6)	12		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			CACTGGTGGAGCAGCTGGGAT	0.577000														55			14		0	0	0.001855	0	0
B4GALNT1	2583	broad.mit.edu	37	12	58022613	58022613	+	Silent	SNP	G	C	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr12:58022613G>C	uc001spg.1	-	7	1317	c.885C>G	c.(883-885)ctC>ctG	p.L295L	B4GALNT1_uc010sru.2_Silent_p.L240L|B4GALNT1_uc010srv.2_Silent_p.L262L	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	Homo sapiens beta-1,4-N-acetyl-galactosaminyl transferase 1 (B4GALNT1), mRNA.	295					lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|urinary_tract(1)	20	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TACTGGTGATGAGAGCCCGTA	0.577000														162			29		0	0	0.007291	0	0
TSPAN11	441631	broad.mit.edu	37	12	31144797	31144797	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr12:31144797G>T	uc010sju.2	+	7	1089	c.709G>T	c.(709-711)Ggg>Tgg	p.G237W	TSPAN11_uc001rjp.3_Missense_Mutation_p.G237W|TSPAN11_uc010sjv.2_Missense_Mutation_p.G227W	NM_001080509	NP_001073978	A1L157	TSN11_HUMAN	Homo sapiens tetraspanin 11 (TSPAN11), mRNA.	237						integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)	11	all_lung(12;3.11e-10)|Lung NSC(12;5.24e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GCAGATCTGCGGGATGGTTCT	0.572000														111			5		3.59834e-05	0.000453237	0.001168	1	0
ZNF814	730051	broad.mit.edu	37	19	58386284	58386285	+	Missense_Mutation	DNP	TG	CA	CA	rs148592080	by1000genomes	TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:58386284_58386285TG>CA	uc002qqo.2	-	2	745_746	c.473_474CA>TG	c.(472-474)gca>gTG	p.A158V	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.2_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	Homo sapiens zinc finger protein 814 (ZNF814), mRNA.	158				A -> V (in Ref. 1; BAH13293).	regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						TACACCTCTTTGCAAACAACGC	0.490000														29			4		0	0	0.004672	0	0
XIST	7503	broad.mit.edu	37	X	73062205	73062205	+	RNA	SNP	A	T	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chrX:73062205A>T	uc004ebm.1	-	0		c.10384T>A								Homo sapiens X (inactive)-specific transcript (non-protein coding) (XIST), non-coding RNA.																		AAAATAAAGGATGGCAATCCA	0.458000														5			3		0	0	0.000248	0	0
CECR6	27439	broad.mit.edu	37	22	17600670	17600670	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr22:17600670C>T	uc002zmb.2	-	0	1544	c.1348G>A	c.(1348-1350)Gcc>Acc	p.A450T	CECR6_uc002zma.2_Missense_Mutation_p.A95T|BC021738_uc002zmc.3_5'Flank	NM_031890	NP_114096	Q9BXQ6	CECR6_HUMAN	Homo sapiens cat eye syndrome chromosome region, candidate 6 (CECR6), transcript variant 1, mRNA.	450	Poly-Ala.									haematopoietic_and_lymphoid_tissue(1)	1		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		GCCGCTGCGGCCGCGGCGTTG	0.731000														2			3		0	0	0.004672	0	0
WIPI2	26100	broad.mit.edu	37	7	5270477	5270477	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr7:5270477G>C	uc003snv.3	+	12	1480	c.1264G>C	c.(1264-1266)Gac>Cac	p.D422H	WIPI2_uc003snw.3_Missense_Mutation_p.D411H|WIPI2_uc003snx.3_Missense_Mutation_p.D404H|WIPI2_uc003sny.3_Missense_Mutation_p.D393H|WIPI2_uc010ksv.3_Missense_Mutation_p.D278H|WIPI2_uc003soa.3_Missense_Mutation_p.D352H	NM_015610	NP_056425	Q9Y4P8	WIPI2_HUMAN	Homo sapiens WD repeat domain, phosphoinositide interacting 2 (WIPI2), transcript variant 1, mRNA.	422					autophagic vacuole assembly	PAS complex|cytosol|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)	16		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		CTACACAGACGACCTGGGTGC	0.607000														39			11		0	0	0.000978	0	0
FAT4	79633	broad.mit.edu	37	4	126412858	126412858	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr4:126412858G>A	uc003ifj.4	+	16	14881	c.14881G>A	c.(14881-14883)Gaa>Aaa	p.E4961K	FAT4_uc011cgp.2_Missense_Mutation_p.E3202K|FAT4_uc003ifi.1_Missense_Mutation_p.E2438K	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	Homo sapiens FAT tumor suppressor homolog 4 (Drosophila) (FAT4), mRNA.	4961					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGCAGCAAATGAAGAAGGCAA	0.408000														10			7		0	0	0.001984	0	0
CIC	23152	broad.mit.edu	37	19	42793213	42793213	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:42793213G>A	uc002otf.1	+	6	1145	c.1105G>A	c.(1105-1107)Gac>Aac	p.D369N		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	Homo sapiens capicua homolog (Drosophila) (CIC), mRNA.	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CGGAGAAGTAGACAGTCAGGC	0.667000			"""Mis, F, S"""		oligodendroglioma									58			14		0	0	0.002450	0	0
SPTBN4	57731	broad.mit.edu	37	19	41003437	41003437	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:41003437C>T	uc002ony.3	+	6	796	c.710C>T	c.(709-711)gCc>gTc	p.A237V	SPTBN4_uc002onx.3_Missense_Mutation_p.A237V|SPTBN4_uc002onz.3_Missense_Mutation_p.A237V	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	Homo sapiens spectrin, beta, non-erythrocytic 4 (SPTBN4), transcript variant sigma1, mRNA.	237	Actin-binding.|CH 2.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	PML body|cytosol|nuclear matrix|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton	p.A237A(1)		breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AAGTCCAATGCCAACTACAAC	0.657000														62			13		0	0	0.002450	0	0
PCNX	22990	broad.mit.edu	37	14	71572021	71572021	+	Silent	SNP	G	T	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr14:71572021G>T	uc001xmo.2	+	32	6611	c.6165G>T	c.(6163-6165)ggG>ggT	p.G2055G	PCNX_uc010are.1_Silent_p.G1944G|PCNX_uc010arf.1_Silent_p.G843G|PCNX_uc001xmp.2_Silent_p.G139G	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	Homo sapiens pecanex homolog (Drosophila) (PCNX), mRNA.	2055						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		CTGGAGGTGGGACTTCCTGCA	0.493000														17			23		4.54149e-19	6.40133e-18	0.002299	1	0
DNAH17	8632	broad.mit.edu	37	17	76498698	76498698	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr17:76498698G>A	uc010dhp.2	-	32	5290	c.5165C>T	c.(5164-5166)gCt>gTt	p.A1722V	AK127460_uc002jvt.1_Non-coding_Transcript	NM_173628	NP_775899			Homo sapiens dynein, axonemal, heavy chain 17 (DNAH17), mRNA.											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ATCTCTGATAGCGTTTTCATA	0.478000														10			8		0	0	0.003080	0	0
MALAT1	378938	broad.mit.edu	37	11	65265689	65265689	+	RNA	SNP	A	T	T	rs137885794	by1000genomes	TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr11:65265689A>T	uc010roh.2	+	0		c.457A>T								Homo sapiens metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) (MALAT1), non-coding RNA.																		CCATTCGCTTAGTTGGTCTAC	0.488000														23			10		0	0	0.000673	0	0
PPP6R2	9701	broad.mit.edu	37	22	50869699	50869699	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr22:50869699C>A	uc003blb.2	+	11	1645	c.1223C>A	c.(1222-1224)aCa>aAa	p.T408K	PPP6R2_uc003blc.3_Missense_Mutation_p.T408K|PPP6R2_uc003bky.2_Missense_Mutation_p.T408K|PPP6R2_uc003bla.2_Missense_Mutation_p.T409K|PPP6R2_uc003bkz.2_Missense_Mutation_p.T408K|PPP6R2_uc003bld.2_5'UTR	NM_001242898	NP_001229827	O75170	PP6R2_HUMAN	Homo sapiens protein phosphatase 6, regulatory subunit 2 (PPP6R2), transcript variant 1, mRNA.	408						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	22						GAGGAGAGGACAGAAGCCAGC	0.577000														75			14		1.05317e-09	1.44995e-08	0.002450	1	0
NSUN3	63899	broad.mit.edu	37	3	93781971	93781971	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr3:93781971A>G	uc003drl.1	+	0	117	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	DHFRL1_uc003dri.3_5'Flank|DHFRL1_uc003drj.3_5'UTR|DHFRL1_uc021xbk.1_5'Flank|NSUN3_uc003drk.3_Non-coding_Transcript	NM_022072	NP_071355	Q9H649	NSUN3_HUMAN	Homo sapiens NOP2/Sun domain family, member 3 (NSUN3), mRNA.	1							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	18						CAGCGGGACAATGCTGACCCA	0.582000														93			71		0	0	0.003610	0	0
ZNF45	7596	broad.mit.edu	37	19	44419091	44419092	+	Nonsense_Mutation	DNP	CC	TA	TA			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr19:44419091_44419092CC>TA	uc002oxu.2	-	3	595_596	c.496_497GG>TA	c.(496-498)gga>TAa	p.G166*	ZNF45_uc002oxw.2_Nonsense_Mutation_p.G166*	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	Homo sapiens zinc finger protein 45 (ZNF45), mRNA.	166					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						ACAATGTTCTCCTTTGTAGGGT	0.401000														49			18		0	0	0.004672	0	0
SYNJ1	8867	broad.mit.edu	37	21	34037380	34037380	+	Splice_Site	SNP	C	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr21:34037380C>A	uc002yqh.2	-	18	2263	c.2263_splice	c.e18-1	p.G755_splice	SYNJ1_uc011ads.1_Splice_Site_p.G711_splice|SYNJ1_uc002yqf.2_Splice_Site_p.G716_splice|SYNJ1_uc002yqg.2_Splice_Site_p.G711_splice|SYNJ1_uc002yqi.2_Splice_Site_p.G755_splice	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	Homo sapiens synaptojanin 1 (SYNJ1), transcript variant 1, mRNA.	716	Catalytic (Potential).						RNA binding|inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						TAGCATCCTTCCCTGAAAGCA	0.353000														15			12		2.27111e-07	3.05568e-06	0.001368	1	0
FLG2	388698	broad.mit.edu	37	1	152325088	152325088	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr1:152325088C>T	uc001ezw.4	-	2	5247	c.5174G>A	c.(5173-5175)gGa>gAa	p.G1725E	AK056431_uc001ezv.3_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	Homo sapiens filaggrin family member 2 (FLG2), mRNA.	1725							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGGCCAGATCCCCTTCTTCC	0.498000														154			55		0	0	0.003610	0	0
HGF	3082	broad.mit.edu	37	7	81346642	81346642	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr7:81346642C>G	uc003uhl.3	-	10	1476	c.1311G>C	c.(1309-1311)gaG>gaC	p.E437D	HGF_uc003uhm.3_Missense_Mutation_p.E432D	NM_000601	NP_000592	P14210	HGF_HUMAN	Homo sapiens hepatocyte growth factor (hepapoietin A; scatter factor) (HGF), transcript variant 1, mRNA.	437	Kringle 4.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity	p.E437Q(1)		NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						GGCAGTAATTCTCATTCAGCT	0.443000														38			11		0	0	0.000673	0	0
KRT23	25984	broad.mit.edu	37	17	39092616	39092616	+	Silent	SNP	G	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr17:39092616G>A	uc002hvm.1	-	1	829	c.240C>T	c.(238-240)aaC>aaT	p.N80N	KRT23_uc010wfl.1_Intron|KRT23_uc010cxf.1_Intron|KRT23_uc010cxg.3_Silent_p.N80N|KRT23_uc002hvn.1_Silent_p.N80N	NM_015515	NP_056330	Q9C075	K1C23_HUMAN	Homo sapiens keratin 23 (histone deacetylase inducible) (KRT23), mRNA.	80	Coil 1A.|Rod.					intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000301)|Ovarian(249;0.15)				CCAGGCGGTCGTTGAGATTCT	0.612000														63			43		0	0	0.003610	0	0
GAS2L2	246176	broad.mit.edu	37	17	34077157	34077157	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr17:34077157T>G	uc002hjv.2	-	1	594	c.566A>C	c.(565-567)gAc>gCc	p.D189A		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	Homo sapiens growth arrest-specific 2 like 2 (GAS2L2), mRNA.	189					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CGGCGAGGGGTCGGGCGGGGG	0.741000														38			9		0	0	0.006214	0	0
ALPK2	115701	broad.mit.edu	37	18	56202520	56202520	+	Silent	SNP	C	T	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr18:56202520C>T	uc002lhj.4	-	4	5113	c.4899G>A	c.(4897-4899)gaG>gaA	p.E1633E	ALPK2_uc002lhk.1_Silent_p.E964E	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	Homo sapiens alpha-kinase 2 (ALPK2), mRNA.	1633							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TTTGAAGCACCTCTATTTTAG	0.448000														43			28		0	0	0.004656	0	0
IL17RD	54756	broad.mit.edu	37	3	57132135	57132135	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr3:57132135G>T	uc003dil.3	-	11	1685	c.1596C>A	c.(1594-1596)aaC>aaA	p.N532K	IL17RD_uc003dik.3_Missense_Mutation_p.N508K|IL17RD_uc010hna.3_Missense_Mutation_p.N388K|IL17RD_uc011bex.1_Missense_Mutation_p.N388K	NM_017563	NP_060033	Q8NFM7	I17RD_HUMAN	Homo sapiens interleukin 17 receptor D (IL17RD), mRNA.	532						Golgi membrane|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		TCCGGAAGTAGTTCCTTCTGC	0.577000														22			6		0.000157383	0.00194106	0.003080	1	0
RPA2	6118	broad.mit.edu	37	1	28233446	28233446	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr1:28233446T>C	uc001bpe.1	-	3	608	c.326A>G	c.(325-327)gAc>gGc	p.D109G	RPA2_uc010ofp.1_Missense_Mutation_p.D13G	NM_002946	NP_002937	P15927	RFA2_HUMAN	Homo sapiens replication protein A2, 32kDa (RPA2), mRNA.	109	Asp/Glu-rich (acidic).				DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|cell cycle checkpoint|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|regulation of double-strand break repair via homologous recombination|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor A complex|PML body	protein phosphatase binding|single-stranded DNA binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|prostate(3)|skin(1)	11		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.62e-24)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00294)|STAD - Stomach adenocarcinoma(196;0.00308)|BRCA - Breast invasive adenocarcinoma(304;0.00613)|READ - Rectum adenocarcinoma(331;0.0649)		TACATCTGTGTCAACCCACTG	0.393000								Direct reversal of damage;Nucleotide excision repair (NER)						26			4		0	0	0.000248	0	0
CEP350	9857	broad.mit.edu	37	1	179955328	179955329	+	Frame_Shift_Ins	INS	-	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr1:179955328_179955329insA	uc001gnt.3	+	1	395_396	c.12_13insA	c.(10-15)agcaaafs	p.S4fs	CEP350_uc001gnr.1_Frame_Shift_Ins_p.Q18fs|CEP350_uc009wxl.2_Frame_Shift_Ins_p.S4fs	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	Homo sapiens centrosomal protein 350kDa (CEP350), mRNA.	4						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						TGAGGAGCAGCAAATCAAAAGA	0.322													---	4	---	---	2	---					
DZIP1L	199221	broad.mit.edu	37	3	137783520	137783521	+	Frame_Shift_Ins	INS	-	A	A			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr3:137783520_137783521insA	uc003erq.3	-	14	2454_2455	c.2091_2092insT	c.(2089-2094)tttatgfs	p.F697fs		NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	Homo sapiens DAZ interacting protein 1-like (DZIP1L), transcript variant 1, mRNA.	697						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						GCATTGGGCATAAAAAACAGAC	0.515													---	295	---	---	78	---					
SNAPC4	6621	broad.mit.edu	37	9	139277995	139277997	+	In_Frame_Del	DEL	GCT	-	-	rs34222232		TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr9:139277995_139277997delGCT	uc004chh.3	-	14	1633_1635	c.1624_1626delAGC	c.(1624-1626)agcdel	p.S542del		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	Homo sapiens small nuclear RNA activating complex, polypeptide 4, 190kDa (SNAPC4), mRNA.	542					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity	p.S542delS(4)		biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CGTCCTCCTCgctgctgctgctg	0.690													---	3	---	---	3	---					
CD44	960	broad.mit.edu	37	11	35222633	35222634	+	Frame_Shift_Ins	INS	-	ACCAC	ACCAC			TCGA-D3-A3CC-06A-11D-A19A-08	TCGA-D3-A3CC-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	287a6ff8-a2e4-4d46-874a-46cc88cb5e12	45cc5a5b-c98c-4fbd-ab95-eb1b51ebd565	g.chr11:35222633_35222634insACCAC	uc001mvu.3	+	7	1361_1362	c.927_928insACCAC	c.(925-930)tcaaccfs	p.S309fs	CD44_uc021qfw.1_Intron|CD44_uc001mvv.3_Frame_Shift_Ins_p.S266fs|CD44_uc001mvw.3_Intron|CD44_uc001mwc.4_Intron|CD44_uc001mvx.3_Intron|CD44_uc010rer.2_Intron|CD44_uc001mvy.3_Intron|CD44_uc009ykh.3_Intron|CD44_uc010reu.2_Intron|CD44_uc010res.2_Intron|CD44_uc010ret.2_Intron	NM_000610	NP_000601	P16070	CD44_HUMAN	Homo sapiens CD44 molecule (Indian blood group) (CD44), transcript variant 1, mRNA.	309	Stem.				cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of apoptosis|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	Golgi apparatus|cell surface|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|skin(1)	23	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	TCACAGTTTCAACCACACCACG	0.455													---	106	---	---	12	---