Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PARP4	143	broad.mit.edu	37	13	25005568	25005568	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr13:25005568A>C	uc001upl.3	-	31	4899	c.4793T>G	c.(4792-4794)cTt>cGt	p.L1598R		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	Homo sapiens poly (ADP-ribose) polymerase family, member 4 (PARP4), mRNA.	1598	Interaction with the major vault protein.				DNA repair|cell death|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|NAD+ ADP-ribosyltransferase activity|enzyme binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		ATTTGTATTAAGATTTAATAT	0.289000														11			33		0	0	1	0	0
WDR13	64743	broad.mit.edu	37	X	48458075	48458075	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chrX:48458075C>G	uc004dkj.2	+	3	998	c.493C>G	c.(493-495)Cat>Gat	p.H165D	WDR13_uc004dkk.2_Missense_Mutation_p.H73D|WDR13_uc004dkl.4_Missense_Mutation_p.H73D|WDR13_uc011mme.2_Missense_Mutation_p.H43D	NM_017883	NP_001159898	Q9H1Z4	WDR13_HUMAN	Homo sapiens WD repeat domain 13 (WDR13), transcript variant 1, mRNA.	165						cytoplasm|nucleus				endometrium(1)|large_intestine(4)|lung(4)|ovary(2)	11						GGGCATGTATCATGTTTTTGA	0.597000														34			21		0	0	1	0	0
OR14A16	284532	broad.mit.edu	37	1	247978230	247978230	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr1:247978230C>T	uc001idm.1	-	0	802	c.802G>A	c.(802-804)Gat>Aat	p.D268N		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	Homo sapiens olfactory receptor, family 14, subfamily A, member 16 (OR14A16), mRNA.	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						ATTACAGCATCCAAAATAGAA	0.423000														57			9		0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97771765	97771765	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr1:97771765T>G	uc001drv.3	-	16	2284	c.2147A>C	c.(2146-2148)gAt>gCt	p.D716A		NM_000110	NP_000101	Q12882	DPYD_HUMAN	Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, mRNA.	716					'de novo' pyrimidine base biosynthetic process|UMP biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|NADP binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GCTCACAATATCAGTGACATT	0.458000														194			5		0	0	1	0	0
KCNG2	26251	broad.mit.edu	37	18	77659210	77659210	+	Silent	SNP	G	A	A			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr18:77659210G>A	uc010xfl.2	+	1	795	c.795G>A	c.(793-795)tcG>tcA	p.S265S		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	Homo sapiens potassium voltage-gated channel, subfamily G, member 2 (KCNG2), mRNA.	265					energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity			breast(2)|endometrium(4)|lung(7)|skin(1)|upper_aerodigestive_tract(4)	18		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		TCTACGTGTCGCTGCTGCTGG	0.697000														24			4		0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55968150	55968150	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr4:55968150A>C	uc003has.3	-	14	2482	c.2180T>G	c.(2179-2181)gTg>gGg	p.V727G	KDR_uc003hat.1_Missense_Mutation_p.V727G	NM_002253	NP_002244	P35968	VGFR2_HUMAN	Homo sapiens kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR), mRNA.	727	Ig-like C2-type 7.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|Hsp90 protein binding|growth factor binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CTCCTTCCTCACTCTGCGGAT	0.453000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)				36			38		0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77305423	77305423	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr4:77305423G>T	uc003hkb.4	-	4	697	c.544C>A	c.(544-546)Cat>Aat	p.H182N	CCDC158_uc003hkd.3_Missense_Mutation_p.H182N	NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	Homo sapiens coiled-coil domain containing 158 (CCDC158), mRNA.	182										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						ACTCCCTCATGACTAAGCATC	0.408000														46			26		3.01185e-09	3.27957e-09	1	1	0
KIAA0141	9812	broad.mit.edu	37	5	141316848	141316848	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr5:141316848A>G	uc003lls.3	+	10	1357	c.1235A>G	c.(1234-1236)tAc>tGc	p.Y412C	KIAA0141_uc003llt.3_Missense_Mutation_p.Y412C	NM_001142603	NP_055588	Q14154	DELE_HUMAN	Homo sapiens KIAA0141 (KIAA0141), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.	412					apoptosis|regulation of caspase activity	mitochondrion	protein binding			endometrium(3)|large_intestine(4)|lung(5)|skin(1)|urinary_tract(3)	16		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGAGATGTTACCAGCAGTCA	0.557000														65			84		0	0	1	0	0
BC063132	0	broad.mit.edu	37	GL000241.1	25551	25551	+	RNA	SNP	A	G	G			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chrGL000241.1:25551A>G	uc011mgv.2	-	3		c.441T>C								Homo sapiens cDNA clone IMAGE:4673444, containing frame-shift errors.																		ATCCATTTCAATGGCTATGGT	0.378000														343			16		0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226378288	226378288	+	Silent	SNP	C	T	T			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr2:226378288C>T	uc002voe.2	+	2	598	c.423C>T	c.(421-423)ccC>ccT	p.P141P	NYAP2_uc010fxa.1_Intron	NM_020864	NP_065915	Q9P242	K1486_HUMAN	Homo sapiens neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 (NYAP2), mRNA.	141																	AACCACCACCCAAACCCAAGA	0.577000														4			15		0	0	1	0	0
PTDSS2	81490	broad.mit.edu	37	11	488240	488240	+	Silent	SNP	C	T	T			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr11:488240C>T	uc001lpj.3	+	6	839	c.663C>T	c.(661-663)agC>agT	p.S221S		NM_030783	NP_110410	Q9BVG9	PTSS2_HUMAN	Homo sapiens phosphatidylserine synthase 2 (PTDSS2), mRNA.	221						integral to membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|skin(1)	9		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;2.76e-26)|Epithelial(43;2.56e-25)|OV - Ovarian serous cystadenocarcinoma(40;7.54e-20)|BRCA - Breast invasive adenocarcinoma(625;8.76e-05)|Lung(200;0.0407)|LUSC - Lung squamous cell carcinoma(625;0.0735)	Phosphatidylserine(DB00144)	TGATCATCAGCGTGATGTTCG	0.642000														24			15		0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41548083	41548083	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr8:41548083G>T	uc003xok.3	-	31	3977	c.3893C>A	c.(3892-3894)tCt>tAt	p.S1298Y	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.3_Missense_Mutation_p.S614Y|ANK1_uc003xoi.3_Missense_Mutation_p.S1298Y|ANK1_uc003xoj.3_Missense_Mutation_p.S1298Y|ANK1_uc003xol.3_Missense_Mutation_p.S1298Y|ANK1_uc003xom.3_Missense_Mutation_p.S1339Y	NM_020476	NP_065209	P16157	ANK1_HUMAN	Homo sapiens ankyrin 1, erythrocytic (ANK1), transcript variant 1, mRNA.	1298					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CAGGTTCCCAGAGAGTTCTGC	0.562000														64			21		6.21321e-17	7.08017e-17	1	1	0
MACF1	23499	broad.mit.edu	37	1	39797463	39797463	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr1:39797463G>T	uc021olw.1	+	0	523	c.523G>T	c.(523-525)Ggg>Tgg	p.G175W	MACF1_uc021ols.1_Intron|MACF1_uc001cdc.2_Intron|MACF1_uc021olt.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdb.1_Intron	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	Homo sapiens microtubule-actin crosslinking factor 1 (MACF1), transcript variant 1, mRNA.	1740	Actin-binding.|CH 1.				Golgi to plasma membrane protein transport|Wnt receptor signaling pathway|cell cycle arrest|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|wound healing	Golgi apparatus|microtubule|ruffle membrane	ATPase activity|actin filament binding|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACAATTGGCAGGGGGGATGGT	0.493000														29			16		1.3612e-06	1.44998e-06	1	1	0
AK302879	0	broad.mit.edu	37	15	76074431	76074431	+	Missense_Mutation	SNP	C	T	T	rs149323153	by1000genomes	TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr15:76074431C>T	uc010umm.1	+	7	610	c.533C>T	c.(532-534)tCg>tTg	p.S178L	DNM1P35_uc021sqp.1_Intron|DQ582939_uc002bba.1_5'Flank					SubName: Full=cDNA FLJ59077, highly similar to Golgin subfamily A member 6;									p.S190L(2)									CTCCAGTCCTCGAGCTGCAGA	0.547000														12			3		0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152694294	152694294	+	Nonsense_Mutation	SNP	C	A	A			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr6:152694294C>A	uc021zhb.1	-	56	9608	c.9385G>T	c.(9385-9387)Gaa>Taa	p.E3129*	SYNE1_uc003qot.4_Nonsense_Mutation_p.E3136*|SYNE1_uc003qou.4_Nonsense_Mutation_p.E3129*|SYNE1_uc010kja.2_5'UTR|SYNE1_uc003qov.3_Nonsense_Mutation_p.E207*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	Homo sapiens spectrin repeat containing, nuclear envelope 1 (SYNE1), transcript variant 1, mRNA.	3129					Golgi organization|cell death|cytoskeletal anchoring at nuclear membrane|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	Golgi apparatus|SUN-KASH complex|cytoskeleton|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCAGAAGTTCCCCTTTAGAC	0.363000										HNSCC(10;0.0054)				11			56		1.86277e-20	2.22624e-20	1	1	0
NFATC4	4776	broad.mit.edu	37	14	24842570	24842570	+	Missense_Mutation	SNP	C	T	T	rs144789611		TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr14:24842570C>T	uc001wpc.3	+	3	1874	c.1553C>T	c.(1552-1554)gCg>gTg	p.A518V	NFATC4_uc010alr.3_Missense_Mutation_p.A581V|NFATC4_uc010tok.2_Missense_Mutation_p.A581V|NFATC4_uc010tol.2_Missense_Mutation_p.A581V|NFATC4_uc010als.2_Missense_Mutation_p.A531V|NFATC4_uc010too.2_Missense_Mutation_p.A531V|NFATC4_uc010tom.2_Missense_Mutation_p.A531V|NFATC4_uc010ton.2_Missense_Mutation_p.A531V|NFATC4_uc010toq.2_Missense_Mutation_p.A550V|NFATC4_uc010alt.3_Missense_Mutation_p.A550V|NFATC4_uc010top.2_Missense_Mutation_p.A550V|NFATC4_uc010alu.3_Missense_Mutation_p.A210V|NFATC4_uc010tor.2_Missense_Mutation_p.A518V|NFATC4_uc010tos.2_Missense_Mutation_p.A448V|NFATC4_uc010tot.2_Missense_Mutation_p.A506V|NFATC4_uc010tou.2_Missense_Mutation_p.A448V|NFATC4_uc010tov.2_Missense_Mutation_p.A506V|NFATC4_uc010tow.2_Missense_Mutation_p.A448V|NFATC4_uc010alv.3_Missense_Mutation_p.A506V|NFATC4_uc010tox.2_Missense_Mutation_p.A448V|NFATC4_uc001wpd.3_Missense_Mutation_p.A53V|NFATC4_uc010toy.2_Missense_Mutation_p.A53V|NFATC4_uc010toz.2_Missense_Mutation_p.A53V|NFATC4_uc010tpa.2_5'Flank|NFATC4_uc010tpb.2_5'Flank	NM_004554	NP_001185895	Q14934	NFAC4_HUMAN	Homo sapiens nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 (NFATC4), transcript variant 2, mRNA.	518	RHD.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		AACAACATGGCGGCCAAGTAA	0.547000														8			10		0	0	1	0	0
NOXRED1	122945	broad.mit.edu	37	14	77873092	77873092	+	Silent	SNP	T	C	C			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr14:77873092T>C	uc001xtr.3	-	3	824	c.657A>G	c.(655-657)caA>caG	p.Q219Q	NOXRED1_uc010tvi.2_Silent_p.Q219Q	NM_001113475	NP_001106946	Q6NXP6	CN148_HUMAN	Homo sapiens NADP-dependent oxidoreductase domain containing 1 (NOXRED1), mRNA.	219					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	9						GACAGGTAGCTTGAAGAATCG	0.448000														22			18		0	0	1	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373411	86373411	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr12:86373411C>G	uc010sum.2	-	5	1324	c.1165G>C	c.(1165-1167)Gat>Cat	p.D389H	MGAT4C_uc001tal.4_Missense_Mutation_p.D365H|MGAT4C_uc001taj.4_Missense_Mutation_p.D365H|MGAT4C_uc001tak.4_Missense_Mutation_p.D365H|MGAT4C_uc001tai.4_Missense_Mutation_p.D365H|MGAT4C_uc001tah.4_Missense_Mutation_p.D365H	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	Homo sapiens mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative) (MGAT4C), mRNA.	365					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						AAGTACTCATCAACACTACTG	0.353000														14			9		0	0	1	0	0
LUC7L3	51747	broad.mit.edu	37	17	48822059	48822059	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr17:48822059A>C	uc002isq.3	+	6	746	c.578A>C	c.(577-579)gAa>gCa	p.E193A	LUC7L3_uc002isp.2_Non-coding_Transcript|LUC7L3_uc010wmw.2_Missense_Mutation_p.E117A|LUC7L3_uc002isr.3_Missense_Mutation_p.E193A|LUC7L3_uc002iss.3_Missense_Mutation_p.E193A	NM_016424	NP_057508	O95232	LC7L3_HUMAN	Homo sapiens LUC7-like 3 (S. cerevisiae) (LUC7L3), transcript variant 1, mRNA.	193					RNA splicing|apoptosis|mRNA processing|response to stress	focal adhesion|nuclear speck	DNA binding|mRNA binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	12						GAAGTTTGTGAAGTATGTGGA	0.373000														25			18		0	0	1	0	0
KIT	3815	broad.mit.edu	37	4	55593661	55593661	+	Missense_Mutation	SNP	T	C	C	rs121913513		TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr4:55593661T>C	uc010igr.3	+	10	1814	c.1727T>C	c.(1726-1728)cTt>cCt	p.L576P	KIT_uc010igs.3_Missense_Mutation_p.L572P|KIT_uc010igt.2_Missense_Mutation_p.L25P	NM_000222	NP_000213	P10721	KIT_HUMAN	Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), transcript variant 1, mRNA.	576					male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.L576P(204)|p.V560_L576del(26)|p.Y570_L576del(25)|p.V569_L576del(20)|p.L576del(18)|p.N564_L576del(15)|p.W557_Q575del(7)|p.I563_L576del(6)|p.N564_Y578del(6)|p.Q556_L576del(5)|p.I571_L576del(5)|p.L576F(4)|p.L576_P577insQL(4)|p.Q575_P577>T(4)|p.Y570_Y578del(4)|p.N564_P577del(3)|p.V555_Q575del(2)|p.L576_P577insTQL(2)|p.N567_L576>E(2)|p.T574_Q575insPT(2)|p.E561_P577del(2)|p.N567_L576>KV(2)|p.I571_N587del(2)|p.G565_D579>V(2)|p.L576_P577insPTQL(2)|p.V559_L576del(2)|p.V569_L576>G(2)|p.V560_Y578del(2)|p.I563_P577>TI(1)|p.W557_T575>CP(1)|p.Q575del(1)|p.Y568_Q575>E(1)|p.Y568_L576>CV(1)|p.K558_L576>N(1)|p.N567_N576>KE(1)|p.E561_Y578del(1)|p.Q575_L576ins17(1)|p.E554_L576>DNCSHLSPQQP(1)|p.K558_Q575del(1)|p.E561_D579>P(1)|p.Q575_K581del(1)|p.L576_P577del(1)|p.V559_S590del(1)|p.Q556_L576>H(1)|p.Q575_W582>L(1)|p.(550_592)ins7(1)|p.N567_P577del(1)|p.Q575_W582>R(1)|p.V569_P577del(1)|p.V569_Q575>E(1)|p.P573_D579del(1)|p.T574_F584del(1)|p.L576_G592del(1)|p.K558_L576>NV(1)|p.K558_L576del(1)|p.Y553_L576>NCLHLYSSQ(1)|p.Y570_L576>R(1)|p.V569_Q575del(1)|p.N567_Y578>ED(1)|p.Y570_L576delYIDPTQL(1)|p.L576_P577insPT(1)|p.Q575_L576ins15(1)|p.T574_Q575ins12(1)|p.Q575_D579del(1)|p.T574_K581del(1)|p.T574_H580del(1)|p.L576_P577ins15(1)|p.V569_Y578del(1)|p.N567_L576>I(1)|p.Q556_Q575del(1)|p.N567_L576del(1)		NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCAACACAACTTCCTTATGAT	0.408000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors					24			491		0	0	1	0	0
SPATC1	375686	broad.mit.edu	37	8	145095490	145095490	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr8:145095490C>T	uc011lkw.2	+	2	890	c.788C>T	c.(787-789)cCc>cTc	p.P263L	SPATC1_uc011lkx.2_Missense_Mutation_p.P263L	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	Homo sapiens spermatogenesis and centriole associated 1 (SPATC1), transcript variant 1, mRNA.	263										NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACTGAGCCCCCCCAGTCGACC	0.617000														151			25		0	0	1	0	0
TMEM173	340061	broad.mit.edu	37	5	138860911	138860911	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr5:138860911A>G	uc003lep.3	-	3	546	c.244T>C	c.(244-246)Tgg>Cgg	p.W82R		NM_198282	NP_938023	Q86WV6	TM173_HUMAN	Homo sapiens transmembrane protein 173 (TMEM173), nuclear gene encoding mitochondrial protein, mRNA.	82					activation of innate immune response|apoptosis|cellular response to exogenous dsRNA|defense response to virus|innate immune response|interferon-beta production|positive regulation of defense response to virus by host|positive regulation of protein binding|positive regulation of protein import into nucleus, translocation|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane|perinuclear region of cytoplasm|plasma membrane	protein homodimerization activity|protein kinase binding|transcription factor binding			endometrium(1)|kidney(1)|lung(6)|upper_aerodigestive_tract(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			ACAGTCCTCCAGTAGCTGCCC	0.662000														10			22		0	0	1	0	0
LOC399753	399753	broad.mit.edu	37	10	49218498	49218498	+	Silent	SNP	A	G	G			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr10:49218498A>G	uc001jgd.3	-	7	1800	c.1641T>C	c.(1639-1641)tcT>tcC	p.S547S	DQ588224_uc001jge.1_5'Flank					Homo sapiens uncharacterized LOC399753 (LOC399753), non-coding RNA.																		GCTGGCCCAGAGACAGCTCAG	0.582000														9			5		0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348674	197348674	+	RNA	SNP	A	G	G	rs144273946	by1000genomes	TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr3:197348674A>G	uc011bug.2	-	3		c.417T>C			LOC220729_uc003fxy.3_Non-coding_Transcript|LOC220729_uc010iao.2_Intron					Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) pseudogene (LOC220729), non-coding RNA.																		GGCTCTGTCCACCAAATGCAC	0.478000														79			5		0	0	1	0	0
RDH5	5959	broad.mit.edu	37	12	56118106	56118106	+	Splice_Site	SNP	A	G	G			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr12:56118106A>G	uc001shk.3	+	5	917	c.734_splice	c.e5-1	p.Y245_splice	RDH5_uc021qyt.1_Splice_Site_p.Y108_splice|RDH5_uc001shl.3_Splice_Site_p.Y245_splice	NM_002905	NP_002896	Q92781	RDH1_HUMAN	Homo sapiens retinol dehydrogenase 5 (11-cis/9-cis) (RDH5), transcript variant 2, mRNA.	245					response to stimulus|visual perception	membrane	binding|retinol dehydrogenase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|skin(1)	12					NADH(DB00157)|Vitamin A(DB00162)	GGGGCTGCAGACCTGAAAATG	0.577000											OREG0021908	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		15			20		0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233135047	233135047	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr1:233135047G>A	uc001hvl.2	-	30	5642	c.5407C>T	c.(5407-5409)Cgc>Tgc	p.R1803C	PCNXL2_uc001hvk.1_Missense_Mutation_p.R455C|PCNXL2_uc001hvm.1_Non-coding_Transcript	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	Homo sapiens pecanex-like 2 (Drosophila) (PCNXL2), transcript variant 1, mRNA.	1803						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				ATACTGCCGCGCTCCGGATTG	0.557000														18			3		0	0	1	0	0
OR4S1	256148	broad.mit.edu	37	11	48328357	48328357	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr11:48328357C>G	uc010rhu.2	+	0	583	c.583C>G	c.(583-585)Ctc>Gtc	p.L195V		NM_001004725	NP_001004725	Q8NGB4	OR4S1_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily S, member 1 (OR4S1), mRNA.	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|skin(3)	21						CATGGTAGGTCTCATCGTGGT	0.448000														44			23		0	0	1	0	0
OR5T2	219464	broad.mit.edu	37	11	55999650	55999650	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr11:55999650C>T	uc010rjc.2	-	0	1012	c.1012G>A	c.(1012-1014)Gac>Aac	p.D338N		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily T, member 2 (OR5T2), mRNA.	338					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					TTCATTGAGTCTTTTACATCT	0.333000														23			19		0	0	1	0	0
TUSC5	286753	broad.mit.edu	37	17	1198820	1198820	+	Silent	SNP	C	T	T			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr17:1198820C>T	uc002fsi.1	+	1	762	c.423C>T	c.(421-423)ggC>ggT	p.G141G		NM_172367	NP_758955	Q8IXB3	TUSC5_HUMAN	Homo sapiens tumor suppressor candidate 5 (TUSC5), mRNA.	141					response to biotic stimulus	integral to membrane				endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|prostate(4)|skin(2)	15				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		ACGTGGACGGCGCCCGGAGGC	0.622000														81			70		0	0	1	0	0
SLC7A14	57709	broad.mit.edu	37	3	170244647	170244647	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr3:170244647G>T	uc003fgz.2	-	1	395	c.79C>A	c.(79-81)Cta>Ata	p.L27I	CLDN11_uc011bpt.1_Intron|CLDN11_uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	Homo sapiens solute carrier family 7 (orphan transporter), member 14 (SLC7A14), mRNA.	27						integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			TTGGTGCGTAGGATCCTGGAG	0.587000														9			6		0.00116845	0.00121817	1	1	0
FBXO33	254170	broad.mit.edu	37	14	39870734	39870734	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr14:39870734G>T	uc001wvk.3	-	2	1380	c.1042C>A	c.(1042-1044)Cac>Aac	p.H348N		NM_203301	NP_976046	Q7Z6M2	FBX33_HUMAN	Homo sapiens F-box protein 33 (FBXO33), mRNA.	348										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|urinary_tract(1)	9	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00121)|Epithelial(34;0.169)	GBM - Glioblastoma multiforme(112;0.0425)		AGAGACTTGTGCATTACAGAA	0.428000														47			23		1.55469e-16	1.73136e-16	1	1	0
PTRF	284119	broad.mit.edu	37	17	40557304	40557304	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr17:40557304G>T	uc002hzo.3	-	1	797	c.574C>A	c.(574-576)Ccc>Acc	p.P192T	PTRF_uc010wgi.2_Missense_Mutation_p.P174T	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	Homo sapiens polymerase I and transcript release factor (PTRF), mRNA.	192					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		TCCTCCTCGGGCCGCTCGCCC	0.647000														97			62		8.3131e-28	1.01835e-27	1	1	0
LOC220729	220729	broad.mit.edu	37	3	197348739	197348739	+	Splice_Site	SNP	G	C	C			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr3:197348739G>C	uc011bug.2	-	4		c.352_splice	c.e4-1		LOC220729_uc003fxy.3_Splice_Site|LOC220729_uc010iao.2_Intron					Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) pseudogene (LOC220729), non-coding RNA.																		TAATTTTCTAGCTGTGAAAGA	0.398000														76			5		0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324558	152324559	+	Frame_Shift_Del	DEL	TG	-	-	rs140875805	byFrequency	TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr1:152324558_152324559delTG	uc001ezw.4	-	2	5776_5777	c.5703_5704delCA	c.(5701-5706)cacagcfs	p.H1901fs	AK056431_uc001ezv.3_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	Homo sapiens filaggrin family member 2 (FLG2), mRNA.	1901							calcium ion binding|structural molecule activity	p.H1901fs*30(2)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGCTTGGCTGTGTGTGTGTC	0.515													---	387	---	---	11	---					
ADD3	120	broad.mit.edu	37	10	111893350	111893350	+	Frame_Shift_Del	DEL	A	-	-			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr10:111893350delA	uc001kyu.3	+	14	2251	c.2095delA	c.(2095-2097)aaafs	p.K699fs	ADD3_uc001kyt.4_Frame_Shift_Del_p.K699fs|ADD3_uc001kys.4_Frame_Shift_Del_p.K667fs|ADD3_uc001kyv.3_Frame_Shift_Del_p.K699fs|ADD3_uc001kyw.3_Frame_Shift_Del_p.K667fs|ADD3_uc001kyx.3_Frame_Shift_Del_p.K272fs	NM_016824	NP_058432	Q9UEY8	ADDG_HUMAN	Homo sapiens adducin 3 (gamma) (ADD3), transcript variant 1, mRNA.	699	Interaction with calmodulin (Potential).					cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton	p.N698K(1)		central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	29		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		GAAAAAGAACAAAAAAAAGGA	0.333													---	367	---	---	8	---					
TBC1D17	79735	broad.mit.edu	37	19	50391745	50391745	+	Frame_Shift_Del	DEL	C	-	-			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chr19:50391745delC	uc002pqo.3	+	16	2110	c.1811delC	c.(1810-1812)tcgfs	p.S604fs	TBC1D17_uc010ybg.2_Frame_Shift_Del_p.S571fs|TBC1D17_uc002pqp.3_Frame_Shift_Del_p.S255fs|TBC1D17_uc002pqr.3_Frame_Shift_Del_p.S255fs|IL4I1_uc002pqt.1_3'UTR|IL4I1_uc021uxy.1_3'UTR|IL4I1_uc002pqu.2_3'UTR|IL4I1_uc010eno.2_3'UTR|IL4I1_uc002pqv.2_3'UTR	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	Homo sapiens TBC1 domain family, member 17 (TBC1D17), transcript variant 1, mRNA.	604	Pro-rich.					intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CACAGCCCCTCGCCCACCGCC	0.736													---	4	---	---	2	---					
GAGE2B	645037	broad.mit.edu	37	X	49208295	49208296	+	In_Frame_Ins	INS	-	TAT	TAT			TCGA-D3-A51K-06A-11D-A25O-08	TCGA-D3-A51K-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4B76091B-1C54-4BF8-8943-3D68FE5C7251	CA87B7AF-4D8D-4BEB-BC55-BD54A4823BEC	g.chrX:49208295_49208296insTAT	uc004dnv.4	+	1	140_141	c.24_25insTAT	c.(22-27)insTAT	p.9_10insY	GAGE2B_uc004dnl.4_Intron|GAGE2B_uc022bwc.1_Intron|GAGE2B_uc011mne.2_Intron|GAGE2B_uc004dnn.4_Intron|GAGE2B_uc011mnf.2_Intron|GAGE2B_uc004dnq.4_Intron|GAGE2B_uc004dnr.4_Intron|GAGE2B_uc004dnk.4_Intron|GAGE2B_uc004dno.4_Intron|GAGE2B_uc004dnp.4_Intron|GAGE2B_uc010njc.3_In_Frame_Ins_p.9_10insY|GAGE2B_uc004dnt.4_In_Frame_Ins_p.9_10insY|GAGE2B_uc004dnu.4_In_Frame_Ins_p.9_10insY	NM_001127212	NP_001091881			Homo sapiens G antigen 2A (GAGE2A), mRNA.																		GAAGATCGACCTATCGGCCTAG	0.465													---	4	---	---	3	---