Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NDST4	64579	broad.mit.edu	37	4	115767006	115767006	+	Silent	SNP	G	A	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr4:115767006G>A	uc003ibu.3	-	9	2767	c.2088C>T	c.(2086-2088)ccC>ccT	p.P696P	NDST4_uc010imw.3_Non-coding_Transcript	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	Homo sapiens N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 (NDST4), mRNA.	696	Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CCCTGTCTGAGGGGTCAATGA	0.423000														31			15		0	0	1	0	0
ACSF3	197322	broad.mit.edu	37	16	89180886	89180886	+	Missense_Mutation	SNP	C	T	T	rs144907664		TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr16:89180886C>T	uc010cig.2	+	4	1325	c.1117C>T	c.(1117-1119)Cgc>Tgc	p.R373C	ACSF3_uc010cih.2_Missense_Mutation_p.R108C|ACSF3_uc002fmp.3_Missense_Mutation_p.R373C|ACSF3_uc021tmq.1_Missense_Mutation_p.R373C|ACSF3_uc010cii.2_Non-coding_Transcript	NM_001127214	NP_777577	Q4G176	ACSF3_HUMAN	Homo sapiens acyl-CoA synthetase family member 3 (ACSF3), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.	373					fatty acid metabolic process	mitochondrion	ATP binding|acid-thiol ligase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|lung(9)|prostate(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(80;0.0281)		CACTGCCGTGCGCCTGCCAGG	0.632000														49			8		0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154221393	154221393	+	Missense_Mutation	SNP	C	A	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chrX:154221393C>A	uc004fmt.3	-	3	590	c.419G>T	c.(418-420)aGg>aTg	p.R140M	F8_uc011mzx.1_Missense_Mutation_p.R105M	NM_000132	NP_000123	P00451	FA8_HUMAN	Homo sapiens coagulation factor VIII, procoagulant component (F8), transcript variant 1, mRNA.	140	F5/8 type A 1.|Plastocyanin-like 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTCTTTCTCCCTTTGACTGGT	0.418000														110			8		0.000157383	0.000185487	1	1	0
PTCH2	8643	broad.mit.edu	37	1	45294274	45294274	+	Silent	SNP	C	T	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr1:45294274C>T	uc010olf.2	-	11	1506	c.1494G>A	c.(1492-1494)acG>acA	p.T498T	PTCH2_uc021omv.1_Silent_p.T498T|PTCH2_uc010olg.2_Silent_p.T196T	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	Homo sapiens patched 2 (PTCH2), transcript variant 1, mRNA.	498	SSD.				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity	p.T498M(1)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					CACTGGTGCCCGTGCGCTGCA	0.627000									Basal Cell Nevus syndrome					17			6		0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140605230	140605230	+	Missense_Mutation	SNP	G	T	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr5:140605230G>T	uc003ljb.3	+	0	2153	c.2153G>T	c.(2152-2154)aGg>aTg	p.R718M		NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	Homo sapiens protocadherin beta 14 (PCDHB14), mRNA.	718					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGAGGAGCAGGGCGGCCTCG	0.667000														192			5		0.00198382	0.0021822	1	1	0
ADAMTS7	11173	broad.mit.edu	37	15	79059041	79059041	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr15:79059041T>C	uc002bej.4	-	18	3423	c.3212A>G	c.(3211-3213)aAt>aGt	p.N1071S	ADAMTS7_uc010und.1_3'UTR	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 7 (ADAMTS7), mRNA.	1071					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.N1071S(8)|p.N1071N(2)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CTCGTGGAAATTGATGAAATT	0.617000														37			4		0	0	1	0	0
EDDM3B	64184	broad.mit.edu	37	14	21238708	21238708	+	Silent	SNP	T	G	G			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr14:21238708T>G	uc021ron.1	+	0	399	c.399T>G	c.(397-399)gtT>gtG	p.V133V	EDDM3B_uc001vyd.3_Silent_p.V133V	NM_022360	NP_071755	P56851	EP3B_HUMAN	Homo sapiens epididymal protein 3B (EDDM3B), mRNA.	133					spermatid development	extracellular region				central_nervous_system(1)|kidney(1)|lung(3)|ovary(1)|skin(1)	7						ACGGGTATGTTGATAGCATAG	0.413000														18			11		0	0	1	0	0
BAGE1	0	broad.mit.edu	37	GL000237.1	2525	2525	+	RNA	SNP	C	A	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chrGL000237.1:2525C>A	uc011mgu.1	-	0		c.162G>T								Homo sapiens B melanoma antigen variant f (BAGE1) mRNA, complete cds, alternatively spliced.																		ctcaggccaccctcctaacac	0.637000														17			3		0.004672	0.004818	1	1	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276936	71276936	+	Silent	SNP	G	A	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr11:71276936G>A	uc001oqt.1	+	0	328	c.303G>A	c.(301-303)aaG>aaA	p.K101K		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	Homo sapiens keratin associated protein 5-10 (KRTAP5-10), mRNA.	101	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						GGGGCTCCAAGGGGGGCTGTG	0.692000														117			4		0	0	1	0	0
RGS19	10287	broad.mit.edu	37	20	62705241	62705241	+	Silent	SNP	G	A	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr20:62705241G>A	uc002yhy.3	-	5	886	c.619C>T	c.(619-621)Ctg>Ttg	p.L207L	RGS19_uc002yhz.3_Silent_p.L185L|RGS19_uc002yib.3_Silent_p.L207L	NM_005873	NP_001034556	P49795	RGS19_HUMAN	Homo sapiens regulator of G-protein signaling 19 (RGS19), transcript variant 1, mRNA.	207	Interaction with GIPC.				G-protein coupled receptor protein signaling pathway|autophagy|negative regulation of signal transduction|small GTPase mediated signal transduction	Golgi apparatus|membrane fraction|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			lung(1)|prostate(1)|skin(1)	3	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					GGCCCCTGCAGCAGCAGGGCA	0.672000														67			4		0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39889762	39889762	+	Silent	SNP	C	T	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr1:39889762C>T	uc021olw.1	+	24	11532	c.11532C>T	c.(11530-11532)ggC>ggT	p.G3844G	MACF1_uc021ols.1_Silent_p.G3342G|MACF1_uc001cdc.2_Silent_p.G3321G|MACF1_uc021olt.1_Silent_p.G3342G|MACF1_uc001cda.1_Silent_p.G3229G	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	Homo sapiens microtubule-actin crosslinking factor 1 (MACF1), transcript variant 1, mRNA.	5409					Golgi to plasma membrane protein transport|Wnt receptor signaling pathway|cell cycle arrest|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|wound healing	Golgi apparatus|microtubule|ruffle membrane	ATPase activity|actin filament binding|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGAAGGAGGCAGAATAGCCC	0.468000														54			6		0	0	1	0	0
ALDH18A1	5832	broad.mit.edu	37	10	97396902	97396902	+	Missense_Mutation	SNP	A	G	G			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr10:97396902A>G	uc001kkz.3	-	4	748	c.506T>C	c.(505-507)cTg>cCg	p.L169P	ALDH18A1_uc001kky.3_Missense_Mutation_p.L169P|ALDH18A1_uc010qog.2_Missense_Mutation_p.L58P|ALDH18A1_uc010qoh.2_Intron	NM_002860	NP_002851	P54886	P5CS_HUMAN	Homo sapiens aldehyde dehydrogenase 18 family, member A1 (ALDH18A1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	169	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(9)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	CAAGGCCATCAGCCCACTCTG	0.537000														27			3		0	0	1	0	0
BAGE1	0	broad.mit.edu	37	GL000237.1	2505	2505	+	RNA	SNP	A	C	C			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chrGL000237.1:2505A>C	uc011mgu.1	-	0		c.182T>G								Homo sapiens B melanoma antigen variant f (BAGE1) mRNA, complete cds, alternatively spliced.																		ctccagccccaatcctactgc	0.627000														22			4		0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8862406	8862406	+	Silent	SNP	C	T	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr20:8862406C>T	uc002wnb.3	+	31	3564	c.3561C>T	c.(3559-3561)tcC>tcT	p.S1187S	PLCB1_uc002wna.3_3'UTR	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	Homo sapiens phospholipase C, beta 1 (phosphoinositide-specific) (PLCB1), transcript variant 1, mRNA.	1187					CD24 biosynthetic process|G1 phase|G2/M transition of mitotic cell cycle|activation of meiosis involved in egg activation|cerebral cortex development|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of JNK cascade|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of G-protein coupled receptor protein signaling pathway|regulation of fertilization|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	GTPase activator activity|calcium ion binding|calmodulin binding|enzyme binding|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TCTCCCTGTCCTCAGACCCTG	0.507000														97			14		0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109696380	109696380	+	Missense_Mutation	SNP	G	C	C			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chrX:109696380G>C	uc004eor.2	+	2	2781	c.2535G>C	c.(2533-2535)atG>atC	p.M845I	RGAG1_uc011msr.1_Missense_Mutation_p.M845I	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	Homo sapiens retrotransposon gag domain containing 1 (RGAG1), mRNA.	845										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						CTGGAGCAATGTCCATGCCAC	0.527000														110			66		0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150714208	150714208	+	Missense_Mutation	SNP	A	G	G			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr7:150714208A>G	uc011kvc.2	-	8	2280	c.2204T>C	c.(2203-2205)gTa>gCa	p.V735A	ATG9B_uc003wig.4_Non-coding_Transcript	NM_173681	NP_775952	Q674R7	ATG9B_HUMAN	Homo sapiens ATG9 autophagy related 9 homolog B (S. cerevisiae) (ATG9B), mRNA.	735					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ATCTTGTTGTACTCGGCCCCA	0.652000														11			5		0	0	1	0	0
PPIP5K1	9677	broad.mit.edu	37	15	43827034	43827034	+	Silent	SNP	G	A	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr15:43827034G>A	uc001zrw.3	-	30	4344	c.4140C>T	c.(4138-4140)atC>atT	p.I1380I	PPIP5K1_uc021sjw.1_Silent_p.I1355I|PPIP5K1_uc001zrx.2_Silent_p.I1353I|PPIP5K1_uc001zry.4_Silent_p.I1355I|PPIP5K1_uc021sjx.1_Silent_p.I309I	NM_001130858	NP_001124330	Q6PFW1	VIP1_HUMAN	Homo sapiens diphosphoinositol pentakisphosphate kinase 1 (PPIP5K1), transcript variant 5, mRNA.	1380					inositol metabolic process	cytosol	ATP binding|acid phosphatase activity|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			large_intestine(1)	1						GGTATGGCTGGATGACCTCCT	0.527000														46			18		0	0	1	0	0
MRPS30	10884	broad.mit.edu	37	5	44811183	44811183	+	Missense_Mutation	SNP	G	T	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr5:44811183G>T	uc003joh.3	+	1	712	c.674G>T	c.(673-675)cGa>cTa	p.R225L	MRPS30_uc003joi.1_Non-coding_Transcript	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	Homo sapiens mitochondrial ribosomal protein S30 (MRPS30), nuclear gene encoding mitochondrial protein, mRNA.	225					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(11)|prostate(1)	20	Lung NSC(6;8.08e-07)					CGAAGAGGTCGAATTGATGAC	0.363000														56			3		1	1	1	1	0
ZNF280C	55609	broad.mit.edu	37	X	129362988	129362988	+	Silent	SNP	G	A	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chrX:129362988G>A	uc004evm.3	-	9	1313	c.1110C>T	c.(1108-1110)tgC>tgT	p.C370C	ZNF280C_uc010nrf.2_Silent_p.C370C	NM_017666	NP_060136	Q8ND82	Z280C_HUMAN	Homo sapiens zinc finger protein 280C (ZNF280C), mRNA.	370					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(4)|large_intestine(9)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26						TCTCAATGTGGCACTGCAGTT	0.448000														83			22		0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140262696	140262696	+	Silent	SNP	T	C	C			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr5:140262696T>C	uc003lif.2	+	0	843	c.843T>C	c.(841-843)ttT>ttC	p.F281F	PCDHAC2_uc003lha.2_Intron|PCDHAC2_uc003lhb.2_Intron|PCDHAC2_uc003lhd.2_Intron|PCDHAC2_uc003lhf.2_Intron|PCDHAC2_uc003lhh.1_Intron|PCDHAC2_uc003lhi.2_Intron|PCDHAC2_uc003lhl.2_Intron|PCDHAC2_uc003lhk.1_Intron|PCDHAC2_uc003lho.2_Intron|PCDHAC2_uc003lhn.2_Intron|PCDHAC2_uc003lhq.2_Intron|PCDHAC2_uc003lhs.2_Intron|PCDHAC2_uc003lhu.2_Intron|PCDHAC2_uc003lhw.2_Intron|PCDHAC2_uc003lhx.2_Intron|PCDHAC2_uc003lia.2_Intron|PCDHAC2_uc003lic.2_Intron|PCDHAC2_uc003lie.1_Silent_p.F281F|PCDHAC2_uc003lid.3_Silent_p.F281F	NM_018904	NP_061727	Q9Y5I4	PCDC2_HUMAN	Homo sapiens protocadherin alpha 13 (PCDHA13), transcript variant 1, mRNA.	296	Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTACTCATTTAGAAGGCCTG	0.383000														62			3		0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140953275	140953275	+	Missense_Mutation	SNP	G	T	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chrX:140953275G>T	uc011mwp.2	+	1	142	c.142G>T	c.(142-144)Gat>Tat	p.D48Y		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	Homo sapiens melanoma antigen family C, 3 (MAGEC3), transcript variant 1, mRNA.	48										NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					AAAGGCCACAGATAAGGACTA	0.493000														35			12		0.00185496	0.00211081	1	1	0
BAGE1	0	broad.mit.edu	37	GL000237.1	2516	2516	+	RNA	SNP	T	C	C			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chrGL000237.1:2516T>C	uc011mgu.1	-	0		c.171A>G								Homo sapiens B melanoma antigen variant f (BAGE1) mRNA, complete cds, alternatively spliced.																		atcctactgctcaggccaccc	0.632000														21			4		0	0	1	0	0
T	6862	broad.mit.edu	37	6	166580164	166580164	+	Silent	SNP	C	T	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr6:166580164C>T	uc003qut.1	-	1	673	c.387G>A	c.(385-387)tcG>tcA	p.S129S	T_uc003quu.1_Silent_p.S129S|T_uc003quv.1_Silent_p.S129S	NM_003181	NP_003172	O15178	BRAC_HUMAN	Homo sapiens T, brachyury homolog (mouse) (T), mRNA.	129					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		CGAAGTTGGGCGAGTCGGGGT	0.657000									Chordoma, Familial Clustering of					51			10		0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14063135	14063135	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr11:14063135G>A	uc001mle.3	+	2	681	c.413G>A	c.(412-414)cGg>cAg	p.R138Q		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	Homo sapiens spondin 1, extracellular matrix protein (SPON1), mRNA.	138	Reelin.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		AGCACTCCACGGAGGAGGACC	0.468000														49			26		0	0	1	0	0
PLK2	10769	broad.mit.edu	37	5	57750746	57750746	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr5:57750746T>C	uc003jrn.3	-	12	2038	c.1858A>G	c.(1858-1860)Acc>Gcc	p.T620A	PLK2_uc021xyx.1_Missense_Mutation_p.T606A	NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	Homo sapiens polo-like kinase 2 (PLK2), transcript variant 1, mRNA.	620	POLO box 2.				positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(7)|large_intestine(7)|lung(5)|ovary(3)|prostate(2)|skin(2)	26		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		ACCTGAAAGGTGCCATCATTA	0.403000														85			47		0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21216993	21216993	+	Silent	SNP	G	T	T			TCGA-EB-A4IQ-01A-12D-A25O-08	TCGA-EB-A4IQ-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31A8C6CA-C52E-442F-A6D3-F1238F31E5E6	7F6561A3-7D0D-41EE-99EE-F891DAA6BE34	g.chr9:21216993G>T	uc003zor.1	-	0	318	c.312C>A	c.(310-312)ctC>ctA	p.L104L	IFNA14_uc003zoo.1_Intron	NM_002173	NP_002164	P05015	IFN16_HUMAN	Homo sapiens interferon, alpha 16 (IFNA16), mRNA.	104					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		ATTTGTCTAGGAGGGTCTCAT	0.483000														63			20		6.33239e-15	7.73958e-15	1	1	0