Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ST6GALNAC3	256435	broad.mit.edu	37	1	76877767	76877767	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:76877767T>G	ENST00000328299.3	+	3	436	c.288T>G	c.(286-288)aaT>aaG	p.N96K	ST6GALNAC3_ENST00000464140.1_3'UTR	NM_152996.2	NP_694541.2	Q8NDV1	SIA7C_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	96					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|ovary(3)|prostate(1)|skin(2)	36						AGGTGGGAAATGAGATAGATC	0.473000													4	16					0	0	1.23904e-05	0	0
FRMPD4	9758	broad.mit.edu	37	X	12736333	12736333	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:12736333G>A	ENST00000380682.1	+	16	3894	c.3388G>A	c.(3388-3390)Gaa>Aaa	p.E1130K		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1130					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CGAAGGGAAGGAAGAAGGAGC	0.517000													73	48					0	0	0.000147903	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841468	8841468	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:8841468C>T	ENST00000324060.2	+	1	153	c.78C>T	c.(76-78)ctC>ctT	p.L26L		NM_001004699.1	NP_001004699.1	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z, member 1	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CACGCCAGCTCCTCTTCTCCC	0.527000													13	44					0	0	0.000151284	0	0
SLC35B1	10237	broad.mit.edu	37	17	47781575	47781575	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:47781575G>A	ENST00000240333.6	-	6	663	c.542C>T	c.(541-543)aCc>aTc	p.T181I	SLC35B1_ENST00000415270.2_Missense_Mutation_p.T218I			P78383	S35B1_HUMAN	solute carrier family 35, member B1	181						endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity			endometrium(1)|large_intestine(2)|lung(3)|urinary_tract(1)	7						TCCATCCAGGGTCAGCGATAA	0.537000													11	48					0	0	0.00010058	0	0
NUFIP2	57532	broad.mit.edu	37	17	27613923	27613923	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:27613923C>T	ENST00000225388.4	-	2	1147	c.1089G>A	c.(1087-1089)aaG>aaA	p.K363K	NUFIP2_ENST00000579665.1_Intron	NM_020772.2	NP_065823.1	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein interacting protein 2	363						nucleus|polysomal ribosome	protein binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	24			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			TGAGGTTTTCCTTAACTTTGC	0.403000													73	47					0	0	0.000147903	0	0
BAI2	576	broad.mit.edu	37	1	32205127	32205127	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:32205127G>A	ENST00000373658.3	-	15	2618	c.2277C>T	c.(2275-2277)ctC>ctT	p.L759L	BAI2_ENST00000257070.4_Silent_p.L759L|BAI2_ENST00000398547.1_Silent_p.L692L|BAI2_ENST00000373655.2_Silent_p.L759L|BAI2_ENST00000440175.2_Silent_p.L401L|BAI2_ENST00000398542.1_Silent_p.L692L|BAI2_ENST00000398556.3_Silent_p.L707L|BAI2_ENST00000398538.1_Silent_p.L747L|BAI2_ENST00000527361.1_Silent_p.L759L	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	759					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		TGGGCAGGAAGAGGCGGTCCT	0.682000													5	34					0	0	1.23904e-05	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736134	140736134	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:140736134C>T	ENST00000571252.1	+	1	1367	c.1367C>T	c.(1366-1368)tCc>tTc	p.S456F	PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCATGCTTCCTACTCTGCT	0.483000													45	48					0	0	0.000125731	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19276199	19276199	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:19276199G>A	ENST00000454498.2	-	8	2208	c.1195C>T	c.(1195-1197)Cat>Tat	p.H399Y	CSGALNACT1_ENST00000522854.1_Missense_Mutation_p.H399Y|CSGALNACT1_ENST00000311540.4_Missense_Mutation_p.H399Y|CSGALNACT1_ENST00000544602.1_Missense_Mutation_p.H399Y|CSGALNACT1_ENST00000332246.6_Missense_Mutation_p.H399Y	NM_001130518.1	NP_001123990.1	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 1	399					anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				Colorectal(111;0.182)		ACTGCATCATGGTGGCCGTAT	0.453000													17	28					0	0	9.7654e-05	0	0
FLT4	2324	broad.mit.edu	37	5	180036966	180036966	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:180036966G>A	ENST00000261937.6	-	28	3824	c.3746C>T	c.(3745-3747)tCc>tTc	p.S1249F	FLT4_ENST00000502649.1_Missense_Mutation_p.S1249F|FLT4_ENST00000393347.3_Missense_Mutation_p.S1249F	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1249					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity	p.S1249F(2)		NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CATCCTGGAGGAACCACGGGT	0.577000													21	76					0	0	0.00047179	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858016	9858016	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:9858016G>A	ENST00000396573.2	-	14	3694	c.3385C>T	c.(3385-3387)Cac>Tac	p.H1129Y	GRIN2A_ENST00000396575.2_Missense_Mutation_p.H1129Y|GRIN2A_ENST00000330684.3_Missense_Mutation_p.H1129Y|GRIN2A_ENST00000535259.1_Missense_Mutation_p.H972Y|GRIN2A_ENST00000562109.1_Missense_Mutation_p.H1129Y|GRIN2A_ENST00000404927.2_Missense_Mutation_p.H1129Y	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1129					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGATCTAAGTGGAAACCAGGC	0.522000													14	83					0	0	0.000219431	0	0
JPH1	56704	broad.mit.edu	37	8	75227821	75227821	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:75227821C>T	ENST00000342232.4	-	2	454	c.414G>A	c.(412-414)cgG>cgA	p.R138R		NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	138	Gly-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CGTAGCCATGCCGCATGCCTC	0.677000													13	33					0	0	5.01169e-05	0	0
OTOGL	283310	broad.mit.edu	37	12	80765802	80765802	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:80765802G>A	ENST00000458043.2	+	56	6718	c.6712G>A	c.(6712-6714)Gaa>Aaa	p.E2238K	OTOGL_ENST00000547103.1_Missense_Mutation_p.E2226K|OTOGL_ENST00000546620.1_Missense_Mutation_p.E257K	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TTTCTAGAATGAAGGGATTGT	0.308000													10	43					0	0	3.86212e-05	0	0
CLVS1	157807	broad.mit.edu	37	8	62370879	62370879	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:62370879G>A	ENST00000519846.1	+	6	1227	c.755G>A	c.(754-756)gGa>gAa	p.G252E	CLVS1_ENST00000325897.4_Missense_Mutation_p.G252E|CLVS1_ENST00000518592.1_5'UTR			Q8IUQ0	CLVS1_HUMAN	clavesin 1	252	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						TTCCTGCATGGAAACAATTTA	0.378000													60	123					0	0	0.000147903	0	0
CBX8	57332	broad.mit.edu	37	17	77769887	77769887	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:77769887C>T	ENST00000269385.4	-	4	332	c.215G>A	c.(214-216)cGt>cAt	p.R72H	CBX8_ENST00000485449.1_5'UTR	NM_020649.2	NP_065700.1	Q9HC52	CBX8_HUMAN	chromobox homolog 8	72					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)	14			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CTTGGGTCCACGCTTTTTGGG	0.517000													41	191					0	0	0.000147903	0	0
CACNA1H	8912	broad.mit.edu	37	16	1270426	1270426	+	Missense_Mutation	SNP	C	C	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:1270426C>G	ENST00000348261.5	+	35	6742	c.6494C>G	c.(6493-6495)cCt>cGt	p.P2165R	CACNA1H_ENST00000358590.4_Missense_Mutation_p.P2159R|CACNA1H_ENST00000565831.1_Missense_Mutation_p.P2159R	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	2165					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	AGCGGGGAGCCTGGGGAGGCG	0.716000													4	23					0	0	1.23904e-05	0	0
ISX	91464	broad.mit.edu	37	22	35478548	35478548	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:35478548C>T	ENST00000308700.6	+	2	1219	c.267C>T	c.(265-267)ttC>ttT	p.F89F	ISX_ENST00000404699.2_Silent_p.F89F	NM_001008494.1	NP_001008494.1	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	89						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(12)|ovary(3)|prostate(1)|skin(4)	26						GTACCACCTTCACCACTGAGC	0.562000													18	51					0	0	0.000132079	0	0
RPL26L1	51121	broad.mit.edu	37	5	172386879	172386879	+	Translation_Start_Site	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:172386879G>A	ENST00000521476.1	+	2	127	c.3G>A	c.(1-3)atG>atA	p.M1I	RPL26L1_ENST00000519974.1_Start_Codon_SNP_p.M1I|RPL26L1_ENST00000265100.2_Start_Codon_SNP_p.M1I|RPL26L1_ENST00000519239.1_Start_Codon_SNP_p.M1I			Q9UNX3	RL26L_HUMAN	ribosomal protein L26-like 1	1					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome			breast(1)|endometrium(1)|kidney(1)|lung(2)|prostate(1)|urinary_tract(1)	7	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GGGTCACCATGAAGTTCAATC	0.562000											OREG0017052	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	68					0	0	0.000147903	0	0
SLC2A3	6515	broad.mit.edu	37	12	8083865	8083865	+	Silent	SNP	G	G	A	rs150412980		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:8083865G>A	ENST00000075120.7	-	4	726	c.486C>T	c.(484-486)atC>atT	p.I162I		NM_006931.2	NP_008862.1	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 3	162					carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(14)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				Kidney(36;0.0866)		TTCCAACAACGATGCCCAGCT	0.478000													25	19					0	0	0.000117367	0	0
FBXO42	54455	broad.mit.edu	37	1	16577258	16577258	+	Silent	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:16577258T>C	ENST00000375592.3	-	10	2277	c.2061A>G	c.(2059-2061)gaA>gaG	p.E687E		NM_018994.1	NP_061867.1	Q6P3S6	FBX42_HUMAN	F-box protein 42	687										autonomic_ganglia(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	26		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		ATATGATGAGTTCACCCCTGC	0.448000													33	129					0	0	0.000132358	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529836	5529836	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:5529836C>T	ENST00000311659.4	-	2	1100	c.953G>A	c.(952-954)gGa>gAa	p.G318E	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	318										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCCTGCCTTCCTTGCCTGCT	0.502000													9	33					0	0	3.86212e-05	0	0
MALAT1	378938	broad.mit.edu	37	11	65266456	65266456	+	RNA	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:65266456G>A	ENST00000534336.1	+	0	1224					NR_002819.2																						GAAGGTGATCGAATTCCGGTG	0.498000													33	92					0	0	0.000228196	0	0
AADACL3	126767	broad.mit.edu	37	1	12785497	12785497	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:12785497T>G	ENST00000332530.3	+	3	603	c.377T>G	c.(376-378)tTt>tGt	p.F126C	AADACL3_ENST00000359318.5_Missense_Mutation_p.F196C	NM_001103169.1	NP_001096639.1	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3	196							hydrolase activity			breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	15	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTACTGTTTTTTTCAAAAC	0.468000													48	124					0	0	0.000147903	0	0
VPS13B	157680	broad.mit.edu	37	8	100796656	100796656	+	Silent	SNP	G	G	A	rs145460276		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:100796656G>A	ENST00000358544.2	+	43	8079	c.7968G>A	c.(7966-7968)gcG>gcA	p.A2656A	VPS13B_ENST00000357162.2_Silent_p.A2631A|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2656					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTCTGCTGGCGAGTCTCCACA	0.473000													13	38					0	0	0.00010058	0	0
OR52I1	390037	broad.mit.edu	37	11	4616195	4616195	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:4616195G>A	ENST00000450052.2	+	2	999	c.999G>A	c.(997-999)tgG>tgA	p.W333*	OR52I1_ENST00000530443.2_Nonsense_Mutation_p.W309*			Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I, member 1	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	15		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGGGAATATGGAGTTATCTGA	0.463000													13	48					0	0	0.00010058	0	0
NWD1	284434	broad.mit.edu	37	19	16923560	16923560	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:16923560C>T	ENST00000552788.1	+	17	4292	c.4292C>T	c.(4291-4293)tCt>tTt	p.S1431F	NWD1_ENST00000524140.2_Intron|NWD1_ENST00000549814.1_Missense_Mutation_p.S1389F|NWD1_ENST00000339803.6_Missense_Mutation_p.S1296F|NWD1_ENST00000523826.1_Missense_Mutation_p.S1225F|NWD1_ENST00000379808.3_Intron			Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1431							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CAACAGAGTTCTTACTGCAGA	0.393000													39	137					0	0	0.000437636	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717102	142717102	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:142717102C>T	ENST00000381779.4	-	2	2048	c.1823G>A	c.(1822-1824)cGa>cAa	p.R608Q	SLITRK4_ENST00000338017.4_Missense_Mutation_p.R608Q|SLITRK4_ENST00000356928.1_Missense_Mutation_p.R608Q	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	608						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					AGGAGGACTTCGAATGGGACC	0.418000													16	22					0	0	0.000308642	0	0
KRT83	3889	broad.mit.edu	37	12	52711486	52711486	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:52711486G>A	ENST00000293670.3	-	4	791	c.729C>T	c.(727-729)ttC>ttT	p.F243F		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	243	Coil 1B.|Rod.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		GCCGCCTCAGGAAGTCAATCT	0.627000													11	63					0	0	0.000308642	0	0
UGT2B7	7364	broad.mit.edu	37	4	69962238	69962238	+	Translation_Start_Site	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:69962238G>A	ENST00000305231.7	+	0	46				UGT2B7_ENST00000508661.1_De_novo_Start_InFrame|UGT2B7_ENST00000509763.1_Intron	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7						lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						ATTGCACCAGGATGTCTGTGA	0.403000													8	27					0	0	0.000274275	0	0
ZFAT	57623	broad.mit.edu	37	8	135614365	135614365	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:135614365C>T	ENST00000520727.1	-	7	1860	c.1561G>A	c.(1561-1563)Gaa>Aaa	p.E521K	ZFAT_ENST00000377838.3_Missense_Mutation_p.E533K|ZFAT_ENST00000520214.1_Missense_Mutation_p.E521K|ZFAT_ENST00000523399.1_Missense_Mutation_p.E471K|ZFAT_ENST00000429442.2_Missense_Mutation_p.E521K|ZFAT_ENST00000520356.1_Missense_Mutation_p.E521K	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	533					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CAGGCCTCTTCCTTGAGTGCA	0.652000													5	10					0	0	3.59834e-05	0	0
MECOM	2122	broad.mit.edu	37	3	168807855	168807855	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:168807855C>T	ENST00000464456.1	-	13	3943	c.2743G>A	c.(2743-2745)Gga>Aga	p.G915R	MECOM_ENST00000433243.2_Missense_Mutation_p.G925R|MECOM_ENST00000468789.1_Missense_Mutation_p.G924R|MECOM_ENST00000264674.3_Missense_Mutation_p.G989R|MECOM_ENST00000472280.1_Missense_Mutation_p.G925R|MECOM_ENST00000460814.1_Missense_Mutation_p.G915R|MECOM_ENST00000494292.1_Missense_Mutation_p.G1103R|MECOM_ENST00000392736.3_Missense_Mutation_p.G924R	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						TCAGGGTTTCCTTCATGTAAA	0.423000													5	61					0	0	1.23904e-05	0	0
ZNF300	91975	broad.mit.edu	37	5	150275090	150275090	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:150275090G>A	ENST00000446148.2	-	7	2186	c.1759C>T	c.(1759-1761)Cat>Tat	p.H587Y	ZNF300_ENST00000427179.1_3'UTR|ZNF300_ENST00000418587.2_Missense_Mutation_p.H535Y|ZNF300_ENST00000394226.2_Missense_Mutation_p.H571Y|ZNF300_ENST00000274599.5_Missense_Mutation_p.H571Y	NM_001172831.1	NP_001166302.1	Q96RE9	ZN300_HUMAN	zinc finger protein 300	571					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)	27		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCCCAGTATGAATCCTCTGA	0.433000													10	20					0	0	0.000442599	0	0
SPEF2	79925	broad.mit.edu	37	5	35763799	35763799	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:35763799C>T	ENST00000440995.2	+	26	3781	c.3781C>T	c.(3781-3783)Cac>Tac	p.H1261Y	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Missense_Mutation_p.H1266Y			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1266					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGCAGTATCTCACATGGTAAG	0.413000													18	74					0	0	0.000229342	0	0
SLC6A3	6531	broad.mit.edu	37	5	1441591	1441591	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:1441591G>A	ENST00000270349.9	-	3	428	c.301C>T	c.(301-303)Ccc>Tcc	p.P101S	SLC6A3_ENST00000453492.2_Missense_Mutation_p.P101S	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	101					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGCAGGTAGGGGACCAGGAAG	0.597000													6	37					0	0	0.000274275	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870456	51870456	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:51870456G>A	ENST00000371497.5	+	2	1346	c.459G>A	c.(457-459)agG>agA	p.R153R	TSHZ2_ENST00000603338.2_Silent_p.R150R|TSHZ2_ENST00000329613.6_Silent_p.R150R	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	153					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			GTGAGAGGAGGAACTGTGACA	0.522000													20	98					0	0	9.22233e-05	0	0
LAMP1	3916	broad.mit.edu	37	13	113960916	113960916	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr13:113960916C>T	ENST00000332556.4	+	2	372	c.178C>T	c.(178-180)Cct>Tct	p.P60S	LAMP1_ENST00000397181.3_Missense_Mutation_p.P60S	NM_005561.3	NP_005552.3	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	60	First lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|skin(1)|stomach(2)	16	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			CAAGAGTGGCCCTAAGGTAGG	0.468000													6	31					0	0	8.12818e-05	0	0
MAPK10	5602	broad.mit.edu	37	4	87115540	87115540	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:87115540G>A	ENST00000359221.3	-	3	541	c.15C>T	c.(13-15)ttC>ttT	p.F5F	RP11-778J15.1_ENST00000511917.1_RNA|MAPK10_ENST00000395166.1_5'UTR|MAPK10_ENST00000513839.1_5'UTR|MAPK10_ENST00000395169.3_5'UTR|MAPK10_ENST00000361569.2_Silent_p.F5F|MAPK10_ENST00000449047.2_5'UTR|MAPK10_ENST00000395161.2_Silent_p.F5F			P53779	MK10_HUMAN	mitogen-activated protein kinase 10	5					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			breast(1)|central_nervous_system(1)|stomach(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		AGTAGTATAAGAAATGGAGGC	0.318000													48	154					0	0	0.000147903	0	0
TAS2R5	54429	broad.mit.edu	37	7	141490228	141490228	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:141490228G>A	ENST00000247883.4	+	1	212	c.67G>A	c.(67-69)Gga>Aga	p.G23R		NM_018980.2	NP_061853.1	Q9NYW4	TA2R5_HUMAN	taste receptor, type 2, member 5	23					chemosensory behavior|sensory perception of taste		taste receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9	Melanoma(164;0.0171)					CGGTTTAATTGGAAATGGAAG	0.517000													45	40					0	0	0.000147903	0	0
RBM47	54502	broad.mit.edu	37	4	40438601	40438601	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:40438601G>A	ENST00000381793.2	-	4	1583	c.1187C>T	c.(1186-1188)tCc>tTc	p.S396F	RBM47_ENST00000295971.7_Missense_Mutation_p.S396F|RBM47_ENST00000319592.4_Intron|RBM47_ENST00000381795.6_Intron|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000514014.1_Missense_Mutation_p.S358F			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	396						nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						CCCGAGGTAGGAACCCCTAGG	0.502000													40	108					0	0	0.000147903	0	0
ST6GALNAC4	27090	broad.mit.edu	37	9	130674570	130674570	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:130674570G>A	ENST00000335791.5	-	4	863	c.588C>T	c.(586-588)ttC>ttT	p.F196F	ST6GALNAC4_ENST00000343609.2_Silent_p.F112F|ST6GALNAC4_ENST00000495983.1_5'UTR	NM_175039.3	NP_778204.1	Q9H4F1	SIA7D_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4	196					glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7						TCTCGTCCTGGAAGATCTGGT	0.642000													8	17					0	0	6.40141e-05	0	0
LPHN2	23266	broad.mit.edu	37	1	82446523	82446523	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:82446523G>A	ENST00000370717.2	+	18	3362	c.3146_splice	c.e18+1	p.G1049_splice	LPHN2_ENST00000370721.1_Intron|LPHN2_ENST00000370713.1_Intron|LPHN2_ENST00000370723.1_Splice_Site_p.G1036_splice|LPHN2_ENST00000370727.1_Splice_Site_p.G1049_splice|LPHN2_ENST00000370728.1_Intron|LPHN2_ENST00000359929.3_Intron|LPHN2_ENST00000370730.1_Intron|LPHN2_ENST00000394879.1_Splice_Site_p.G1036_splice|LPHN2_ENST00000370725.1_Splice_Site_p.G1049_splice|LPHN2_ENST00000271029.4_Splice_Site_p.G1049_splice|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000319517.6_Intron|LPHN2_ENST00000370715.1_Intron|LPHN2_ENST00000335786.5_Intron			O95490	LPHN2_HUMAN	latrophilin 2	1034					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GACTTACCTGGGTAAGGTAGA	0.328000													5	60					0	0	1.23904e-05	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12919929	12919929	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:12919929G>A	ENST00000240189.2	+	3	756	c.669G>A	c.(667-669)aaG>aaA	p.K223K		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	223										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGATAAGAAAGCTTTATTGTT	0.388000													30	164					0	0	0.000227799	0	0
NPFFR2	10886	broad.mit.edu	37	4	73013193	73013193	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:73013193C>T	ENST00000308744.6	+	4	1331	c.1233C>T	c.(1231-1233)atC>atT	p.I411I	NPFFR2_ENST00000344413.5_3'UTR|NPFFR2_ENST00000358749.3_Silent_p.I309I|NPFFR2_ENST00000506359.1_3'UTR|NPFFR2_ENST00000395999.1_Silent_p.I312I	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	411					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			AACTGCAGATCATCAACATCT	0.473000													24	52					0	0	0.00047179	0	0
XDH	7498	broad.mit.edu	37	2	31595158	31595158	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:31595158G>A	ENST00000379416.3	-	17	1840	c.1792C>T	c.(1792-1794)Cct>Tct	p.P598S		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	598					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TCGTAGCGAGGAATGTCGTCA	0.642000													29	92					0	0	0.000184323	0	0
RCN3	57333	broad.mit.edu	37	19	50040354	50040354	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:50040354G>A	ENST00000270645.3	+	4	957	c.510G>A	c.(508-510)cgG>cgA	p.R170R		NM_020650.2	NP_065701.2	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	170	EF-hand 3.					endoplasmic reticulum lumen	calcium ion binding|protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		GGGACGAGCGGCGTTTCCGGG	0.582000													23	157					0	0	9.22233e-05	0	0
HTR2C	3358	broad.mit.edu	37	X	114141205	114141205	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:114141205G>A	ENST00000276198.1	+	6	1332	c.604G>A	c.(604-606)Gtg>Atg	p.V202M	HTR2C_ENST00000371950.3_Missense_Mutation_p.R170H|HTR2C_ENST00000371951.1_Missense_Mutation_p.V202M	NM_000868.2	NP_000859.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	202					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	AAAGGTGTTCGTGAACAACAC	0.448000													18	31					0	0	0.000132079	0	0
KCNB2	9312	broad.mit.edu	37	8	73848248	73848248	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:73848248G>A	ENST00000523207.1	+	3	1246	c.658G>A	c.(658-660)Gaa>Aaa	p.E220K		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	220					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GGAGCTGCAGGAAACGGACGA	0.473000													48	191					0	0	0.000125731	0	0
KRT84	3890	broad.mit.edu	37	12	52779260	52779260	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:52779260G>A	ENST00000257951.3	-	1	176	c.110C>T	c.(109-111)tCc>tTc	p.S37F	RP3-416H24.4_ENST00000547174.1_RNA	NM_033045.3	NP_149034.2	Q9NSB2	KRT84_HUMAN	keratin 84	37	Head.					keratin filament	structural constituent of epidermis			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(10)|skin(3)	27	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		ACTCCAACAGGAGACAGAGTT	0.577000													13	50					0	0	0.000308642	0	0
SYNE1	23345	broad.mit.edu	37	6	152786511	152786511	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:152786511C>T	ENST00000367255.5	-	18	2415	c.1814G>A	c.(1813-1815)aGg>aAg	p.R605K	SYNE1_ENST00000448038.1_Missense_Mutation_p.R612K|SYNE1_ENST00000367253.4_Missense_Mutation_p.R605K|SYNE1_ENST00000495090.2_Missense_Mutation_p.R172K|SYNE1_ENST00000341594.5_Missense_Mutation_p.R612K|SYNE1_ENST00000413186.2_Missense_Mutation_p.R605K|SYNE1_ENST00000265368.4_Missense_Mutation_p.R605K|SYNE1_ENST00000423061.1_Missense_Mutation_p.R612K|SYNE1_ENST00000367248.3_Missense_Mutation_p.R595K|SYNE1_ENST00000466159.2_Missense_Mutation_p.R605K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	605					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAGCATGCTCCTCACACTCCT	0.448000										HNSCC(10;0.0054)			8	19					0	0	0.000274275	0	0
OR4Q3	441669	broad.mit.edu	37	14	20215761	20215761	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:20215761C>T	ENST00000331723.1	+	1	175	c.175C>T	c.(175-177)Cct>Tct	p.P59S		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	59					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCTCCAATCTCCTATGTATTA	0.408000													7	21					0	0	3.86212e-05	0	0
RORB	6096	broad.mit.edu	37	9	77280476	77280476	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:77280476G>A	ENST00000376896.2	+	7	1577	c.965G>A	c.(964-966)gGa>gAa	p.G322E	RORB_ENST00000396204.2_Missense_Mutation_p.G333E	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	333	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						CTGTTTGAAGGAAAATATGGA	0.353000													20	90					0	0	0.000375601	0	0
MUC16	94025	broad.mit.edu	37	19	9005597	9005597	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:9005597C>T	ENST00000397910.4	-	46	40012	c.39809G>A	c.(39808-39810)gGa>gAa	p.G13270E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13272	SEA 8.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTGTAGGGTCCCAGCTCAGT	0.557000													10	95					0	0	3.86212e-05	0	0
CENPF	1063	broad.mit.edu	37	1	214813547	214813547	+	Missense_Mutation	SNP	G	G	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:214813547G>C	ENST00000366955.3	+	12	2034	c.1866G>C	c.(1864-1866)tgG>tgC	p.W622C		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	622					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding	p.W622*(1)		NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TTTCTTGTTGGAAAAGTGAAA	0.338000													9	74					0	0	3.86212e-05	0	0
TMED9	54732	broad.mit.edu	37	5	177022360	177022360	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:177022360C>T	ENST00000332598.6	+	5	708	c.651C>T	c.(649-651)atC>atT	p.I217I		NM_017510.4	NP_059980.2	Q9BVK6	TMED9_HUMAN	transmembrane emp24 protein transport domain containing 9	217					transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane				endometrium(1)|large_intestine(1)|lung(5)|prostate(1)|upper_aerodigestive_tract(2)	10	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCGTGGCCATCGGTGTCTGGC	0.612000													28	58					0	0	8.91981e-05	0	0
TENM2	57451	broad.mit.edu	37	5	167631593	167631593	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:167631593C>T	ENST00000519204.1	+	18	3546	c.3428C>T	c.(3427-3429)cCc>cTc	p.P1143L	TENM2_ENST00000520394.1_Missense_Mutation_p.P1032L|TENM2_ENST00000545108.1_Missense_Mutation_p.P1264L|TENM2_ENST00000403607.2_Missense_Mutation_p.P1088L|TENM2_ENST00000518659.1_Missense_Mutation_p.P1264L					teneurin transmembrane protein 2																		CGCATCTTTCCCTCTCGAAAT	0.522000													13	47					0	0	0.000219431	0	0
HERC2P2	400322	broad.mit.edu	37	15	23326585	23326585	+	RNA	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:23326585G>A	ENST00000560464.1	-	0	1795																											GGAGACTGCGGATAAAGACCC	0.418000													18	175					0	0	0.000175454	0	0
PLEKHA5	54477	broad.mit.edu	37	12	19418687	19418687	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:19418687A>G	ENST00000538714.1	+	8	618	c.614A>G	c.(613-615)gAg>gGg	p.E205G	PLEKHA5_ENST00000429027.2_Missense_Mutation_p.E205G|PLEKHA5_ENST00000299275.6_Missense_Mutation_p.E205G|PLEKHA5_ENST00000543806.1_Missense_Mutation_p.E97G|PLEKHA5_ENST00000510738.2_3'UTR|PLEKHA5_ENST00000424268.1_Missense_Mutation_p.E97G|PLEKHA5_ENST00000309364.4_Missense_Mutation_p.E205G|PLEKHA5_ENST00000539256.1_5'UTR|PLEKHA5_ENST00000355397.3_Missense_Mutation_p.E205G|PLEKHA5_ENST00000359180.3_Missense_Mutation_p.E205G|PLEKHA5_ENST00000317589.4_Missense_Mutation_p.E205G	NM_001143821.2	NP_001137293.2	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A member 5	205	PH.						1-phosphatidylinositol binding|protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					CTCTTAGATGAGAAAGAAGAG	0.318000													56	56					0	0	0.000147903	0	0
SCAF1	58506	broad.mit.edu	37	19	50150056	50150056	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:50150056C>T	ENST00000360565.3	+	6	571	c.447C>T	c.(445-447)ccC>ccT	p.P149P		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	149					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GCCTGCTGCCCCGTCTCAGGG	0.642000													6	12					0	0	0.000157383	0	0
ZNF234	10780	broad.mit.edu	37	19	44661433	44661433	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:44661433C>T	ENST00000426739.2	+	6	1522	c.1264C>T	c.(1264-1266)Cac>Tac	p.H422Y	ZNF234_ENST00000592437.1_Missense_Mutation_p.H422Y	NM_006630.2	NP_006621.1	Q14588	ZN234_HUMAN	zinc finger protein 234	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)	23		Prostate(69;0.0435)				TCTGGTAGTCCACACAGGGGA	0.428000													9	33					0	0	0.000274275	0	0
FAM69B	138311	broad.mit.edu	37	9	139616675	139616675	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:139616675G>A	ENST00000371691.1	+	2	1243	c.144G>A	c.(142-144)cgG>cgA	p.R48R	FAM69B_ENST00000371692.4_Silent_p.R135R|SNHG7_ENST00000414282.1_RNA			Q5VUD6	FA69B_HUMAN	family with sequence similarity 69, member B	135						endoplasmic reticulum membrane|integral to membrane				NS(1)|endometrium(3)|large_intestine(2)|lung(1)|prostate(1)	8	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;1.03e-05)|Epithelial(140;0.00013)		CCCCCCGGCGGGAGCTGGTAC	0.627000													5	15					0	0	3.59834e-05	0	0
SLCO1B7	338821	broad.mit.edu	37	12	21172187	21172187	+	Missense_Mutation	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:21172187T>A	ENST00000421593.2	+	2	91	c.91T>A	c.(91-93)Ttg>Atg	p.L31M	SLCO1B3_ENST00000553473.1_Intron|SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000381541.3_Intron|LST3_ENST00000540229.1_Intron	NM_001009562.4	NP_001009562.3			solute carrier organic anion transporter family, member 1B7 (non-functional)											endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(25)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						TCTAGGAAATTTGTTTGTGAT	0.328000													15	11					0	0	0.000422831	0	0
IGSF1	3547	broad.mit.edu	37	X	130408581	130408581	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:130408581C>T	ENST00000370904.1	-	24	4626	c.3716G>A	c.(3715-3717)gGg>gAg	p.G1239E	IGSF1_ENST00000370910.1_Missense_Mutation_p.G1239E|IGSF1_ENST00000370903.3_Missense_Mutation_p.G1253E|IGSF1_ENST00000361420.3_Missense_Mutation_p.G1248E			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	1248	Ig-like C2-type 12.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						ACCTGCTGCCCCCACCAGCTC	0.547000													13	22					0	0	0.00010058	0	0
SAMD7	344658	broad.mit.edu	37	3	169656285	169656285	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:169656285G>A	ENST00000428432.2	+	9	1721	c.1332G>A	c.(1330-1332)atG>atA	p.M444I	SAMD7_ENST00000335556.3_Missense_Mutation_p.M444I	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	444										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GAGGTAGTATGAGAAACTAAA	0.408000													5	15					0	0	8.12818e-05	0	0
RNF213	57674	broad.mit.edu	37	17	78337018	78337018	+	Silent	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:78337018T>C	ENST00000582970.1	+	40	11615	c.11472T>C	c.(11470-11472)cgT>cgC	p.R3824R	CTD-2047H16.4_ENST00000575034.1_RNA|RNF213_ENST00000508628.2_Silent_p.R3873R|CTD-2047H16.4_ENST00000572151.1_RNA|RNF213_ENST00000336301.6_Silent_p.R1897R	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TCAGAAGCCGTCTGCAGAACT	0.547000													90	29					0	0	0.000147903	0	0
PTPRG	5793	broad.mit.edu	37	3	62180762	62180762	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:62180762C>T	ENST00000474889.1	+	10	1622	c.1245C>T	c.(1243-1245)ccC>ccT	p.P415P	PTPRG_ENST00000295874.10_Silent_p.P415P	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	415	Fibronectin type-III.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		ATGTCTCACCCGATAGCCTTT	0.502000													46	46					0	0	0.000147903	0	0
GDF2	2658	broad.mit.edu	37	10	48414365	48414365	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:48414365C>T	ENST00000249598.1	-	2	662	c.503G>A	c.(502-504)gGa>gAa	p.G168E		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	168					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						GACCACGCTTCCTTTCAGGTC	0.507000													17	24					0	0	0.000132079	0	0
CLPTM1L	81037	broad.mit.edu	37	5	1344506	1344506	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:1344506A>C	ENST00000320895.5	-	2	480	c.223T>G	c.(223-225)Ttg>Gtg	p.L75V	CLPTM1L_ENST00000320927.6_Missense_Mutation_p.L75V	NM_030782.3	NP_110409.2	Q96KA5	CLP1L_HUMAN	CLPTM1-like	75					apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		TCCACATTCAAGACCAGGTCG	0.512000													17	30					0	0	0.000175454	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145015874	145015874	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:145015874G>A	ENST00000369359.4	-	3	465	c.427C>T	c.(427-429)Cga>Tga	p.R143*	PDE4DIP_ENST00000478649.2_Nonsense_Mutation_p.R72*|PDE4DIP_ENST00000493130.2_Nonsense_Mutation_p.R72*|PDE4DIP_ENST00000369348.3_Nonsense_Mutation_p.R143*|PDE4DIP_ENST00000530740.1_Nonsense_Mutation_p.R143*|PDE4DIP_ENST00000313382.9_Nonsense_Mutation_p.R72*			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	6			K -> E (in dbSNP:rs1747958).		cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCAAAGTCTCGAAGAGCCTGG	0.438000			T	PDGFRB	MPD								130	897					0	0	0.000147903	0	0
ABCA4	24	broad.mit.edu	37	1	94476861	94476861	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:94476861G>A	ENST00000370225.3	-	39	5627	c.5541C>T	c.(5539-5541)gaC>gaT	p.D1847D	ABCA4_ENST00000536513.1_Silent_p.D117D|ABCA4_ENST00000535881.1_5'UTR	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1847					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TCAGTGCAAGGTCAATGAGGC	0.602000													9	69					0	0	0.000274275	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106681104	106681104	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:106681104C>T	ENST00000526355.1	-	5	1775	c.1307G>A	c.(1306-1308)cGa>cAa	p.R436Q	GUCY1A2_ENST00000282249.2_Missense_Mutation_p.R436Q|GUCY1A2_ENST00000347596.2_Missense_Mutation_p.R457Q	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	436					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		ATGTAGCCCTCGGCCCATGAG	0.463000													9	8					0	0	3.86212e-05	0	0
NIPSNAP1	8508	broad.mit.edu	37	22	29957542	29957542	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:29957542G>A	ENST00000216121.7	-	6	786	c.532C>T	c.(532-534)Ccc>Tcc	p.P178S		NM_001202502.1|NM_003634.3	NP_001189431.1|NP_003625.2	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1 (C. elegans)	178								p.?(1)		large_intestine(2)|lung(2)|skin(1)	5						CCCATTCTGGGCTGTGGCTCA	0.587000													22	63					0	0	0.000229342	0	0
PRKRIR	5612	broad.mit.edu	37	11	76063417	76063417	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:76063417G>A	ENST00000260045.3	-	5	882	c.777C>T	c.(775-777)ttC>ttT	p.F259F		NM_004705.2	NP_004696.2	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	259					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	25						TAATGGAAAAGAAGTGTGAGT	0.438000													15	64					0	0	0.000422831	0	0
DGAT2	84649	broad.mit.edu	37	11	75501706	75501706	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:75501706G>A	ENST00000228027.7	+	4	619	c.358_splice	c.e4-1	p.G120_splice	DGAT2_ENST00000376262.3_Splice_Site_p.G77_splice	NM_032564.4	NP_115953.2	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	120					glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity			endometrium(3)|large_intestine(5)|lung(5)|prostate(2)|skin(2)	17	Ovarian(111;0.103)					TCCCTGGAAGGTGGCAGGAGG	0.542000													14	93					0	0	7.07596e-05	0	0
SLC34A2	10568	broad.mit.edu	37	4	25673336	25673336	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:25673336C>T	ENST00000382051.3	+	9	1091	c.1041C>T	c.(1039-1041)atC>atT	p.I347I	SLC34A2_ENST00000504570.1_Silent_p.I346I|SLC34A2_ENST00000503434.1_Silent_p.I346I	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	347					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				AGGAGAACATCGCCAAATGTG	0.507000			T	ROS1	NSCLC								61	99					0	0	0.000147903	0	0
ZNF235	9310	broad.mit.edu	37	19	44791848	44791848	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:44791848G>A	ENST00000291182.4	-	5	1842	c.1740C>T	c.(1738-1740)ttC>ttT	p.F580F	ZNF235_ENST00000589248.1_Intron|ZNF235_ENST00000589799.1_Intron	NM_004234.4	NP_004225.3	Q14590	ZN235_HUMAN	zinc finger protein 235	580					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29		Prostate(69;0.0352)|all_neural(266;0.116)				AAGCCTGACTGAAACCCTTAC	0.483000													16	22					0	0	0.000422831	0	0
PTPRT	11122	broad.mit.edu	37	20	40730799	40730799	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:40730799C>T	ENST00000373198.3	-	27	3980	c.3745G>A	c.(3745-3747)Gaa>Aaa	p.E1249K	PTPRT_ENST00000373187.1_Missense_Mutation_p.E1227K|PTPRT_ENST00000373190.1_Missense_Mutation_p.E1226K|PTPRT_ENST00000356100.2_Missense_Mutation_p.E1236K|PTPRT_ENST00000373201.1_Missense_Mutation_p.E1217K|PTPRT_ENST00000373193.3_Missense_Mutation_p.E1230K|PTPRT_ENST00000373184.1_Missense_Mutation_p.E1237K	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1227	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity	p.E1249*(1)		NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TTGCTGGATTCTCCGTCCACT	0.547000													7	63					0	0	0.000442599	0	0
PSG11	5680	broad.mit.edu	37	19	43522923	43522923	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:43522923G>A	ENST00000401740.1	-	3	811	c.709_splice	c.e3+1	p.L236_splice	PSG11_ENST00000595312.1_5'UTR|PSG11_ENST00000403486.1_Splice_Site_p.L114_splice|PSG11_ENST00000320078.7_Splice_Site_p.L236_splice|PSG11_ENST00000306322.7_Splice_Site_p.L114_splice			Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	236					female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	26		Prostate(69;0.00682)				GATACTCACGGAGGAGATTCA	0.522000													34	125					0	0	0.000125731	0	0
FABP5	2171	broad.mit.edu	37	8	82196159	82196159	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:82196159G>A	ENST00000396359.1	+	3	672	c.202G>A	c.(202-204)Ggg>Agg	p.G68R	FABP5_ENST00000297258.6_Missense_Mutation_p.G102R			Q01469	FABP5_HUMAN	fatty acid binding protein 5 (psoriasis-associated)	102					epidermis development	cytoplasm	fatty acid binding|protein binding|transporter activity			large_intestine(1)|lung(3)	4	Lung NSC(7;3.57e-05)|all_lung(9;0.00011)		Epithelial(68;0.102)			GGAGTGGGATGGGAAGGAAAG	0.398000													4	19					0	0	1.23904e-05	0	0
OR5P2	120065	broad.mit.edu	37	11	7817599	7817599	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:7817599C>T	ENST00000329434.2	-	1	921	c.891G>A	c.(889-891)ctG>ctA	p.L297L	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153444.1	NP_703145.1	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P, member 2	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	22				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCTCTCTCTTCAGAGCCCCCT	0.408000													12	15					0	0	0.00010058	0	0
SP1	6667	broad.mit.edu	37	12	53776730	53776730	+	Silent	SNP	C	C	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:53776730C>A	ENST00000426431.2	+	3	1038	c.978C>A	c.(976-978)acC>acA	p.T326T	SP1_ENST00000327443.4_Silent_p.T333T	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	333	Ser/Thr-rich.|Transactivation domain B (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		CTACTACCACCAGCAACATGG	0.502000													6	74					5.18039e-06	0.000107805	0.000157383	1	0
KLK3	354	broad.mit.edu	37	19	51363270	51363270	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:51363270G>A	ENST00000326003.2	+	5	714	c.673G>A	c.(673-675)Ggt>Agt	p.G225S	KLK3_ENST00000595952.1_Missense_Mutation_p.G182S|KLK3_ENST00000360617.3_3'UTR	NM_001030047.1|NM_001030048.1|NM_001648.2	NP_001025218.1|NP_001025219.1|NP_001639.1	P07288	KLK3_HUMAN	kallikrein-related peptidase 3	225	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		TGTGCTTCAAGGTATCACGTC	0.542000													14	41					0	0	0.000422831	0	0
NLRP5	126206	broad.mit.edu	37	19	56539262	56539262	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:56539262G>A	ENST00000390649.3	+	7	1663	c.1663G>A	c.(1663-1665)Gga>Aga	p.G555R		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	555	NACHT.					mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CATGGTTCAAGGACTCGGGGA	0.532000													7	28					0	0	0.000157383	0	0
TFAP4	7023	broad.mit.edu	37	16	4311932	4311932	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:4311932G>A	ENST00000204517.6	-	4	701	c.373C>T	c.(373-375)Ccc>Tcc	p.P125S		NM_003223.2	NP_003214.1	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer binding protein 4)	125					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|endometrium(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						CGTCGCTTGGGGGACGAGCCG	0.652000											OREG0023575	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	8					0	0	1.23904e-05	0	0
CHRNB4	1143	broad.mit.edu	37	15	78922166	78922166	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:78922166G>A	ENST00000261751.3	-	5	592	c.481C>T	c.(481-483)Ccc>Tcc	p.P161S	CHRNB4_ENST00000412074.2_Intron	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	161					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						TGGTCGAAGGGAAAGTACTTC	0.562000													17	32					0	0	5.01169e-05	0	0
PPM1F	9647	broad.mit.edu	37	22	22279998	22279998	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:22279998A>C	ENST00000407142.1	-	5	1485	c.425T>G	c.(424-426)gTg>gGg	p.V142G	PPM1F_ENST00000397495.4_Missense_Mutation_p.V310G|PPM1F_ENST00000538191.1_Missense_Mutation_p.V206G|PPM1F_ENST00000263212.5_Missense_Mutation_p.V310G			P49593	PPM1F_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1F	310					apoptosis|protein dephosphorylation	protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	12	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.155)		CATGTGAGACACAAAGCCACC	0.627000													6	7					0	0	0.000157383	0	0
PRSS1	5644	broad.mit.edu	37	7	142458473	142458473	+	Silent	SNP	C	C	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:142458473C>A	ENST00000486171.1	+	2	125	c.108C>A	c.(106-108)ccC>ccA	p.P36P	PRSS1_ENST00000311737.7_Silent_p.P36P			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	36	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			ATTCTGTCCCCTACCAGGTGT	0.532000													8	120					0.000157383	0.00325516	0.000157383	1	0
ZNF335	63925	broad.mit.edu	37	20	44592254	44592254	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:44592254G>T	ENST00000322927.2	-	9	1491	c.1391C>A	c.(1390-1392)cCc>cAc	p.P464H	ZNF335_ENST00000426788.1_Missense_Mutation_p.P309H	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				GCACAGGAAGGGCCTCAAAAG	0.572000													48	64					2.42921e-53	5.14496e-52	0.000147903	1	0
RAP1GAP2	23108	broad.mit.edu	37	17	2901588	2901588	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:2901588C>A	ENST00000254695.8	+	14	1208	c.1118C>A	c.(1117-1119)cCa>cAa	p.P373Q	RAP1GAP2_ENST00000540393.2_Missense_Mutation_p.P354Q|RAP1GAP2_ENST00000366401.4_Missense_Mutation_p.P358Q|RAP1GAP2_ENST00000542807.1_Missense_Mutation_p.P373Q	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	373	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						CCGTTTGTCCCAGACATGATA	0.473000													9	103					0.000274275	0.00566128	0.000274275	1	0
UGT2B7	7364	broad.mit.edu	37	4	69978270	69978270	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:69978270G>A	ENST00000305231.7	+	6	1452	c.1406G>A	c.(1405-1407)cGc>cAc	p.R469H	UGT2B7_ENST00000508661.1_3'UTR|UGT2B7_ENST00000509763.1_3'UTR	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	469					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TTTGTCATGCGCCACAAAGGA	0.463000													19	63					0	0	9.7654e-05	0	0
ARAP3	64411	broad.mit.edu	37	5	141044616	141044616	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:141044616G>A	ENST00000239440.4	-	19	2738	c.2673C>T	c.(2671-2673)ttC>ttT	p.F891F	ARAP3_ENST00000513878.1_Silent_p.F553F|ARAP3_ENST00000512390.1_5'UTR|ARAP3_ENST00000508305.1_Silent_p.F793F	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	891					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						TCCATGCCGTGAAGTCCAGCC	0.652000											OREG0016871	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	31					0	0	1.23904e-05	0	0
WDR47	22911	broad.mit.edu	37	1	109544928	109544928	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:109544928G>T	ENST00000357672.3	-	6	1642	c.1267C>A	c.(1267-1269)Caa>Aaa	p.Q423K	WDR47_ENST00000369962.3_Missense_Mutation_p.Q451K|WDR47_ENST00000361054.3_Missense_Mutation_p.Q423K|WDR47_ENST00000400794.3_Missense_Mutation_p.Q459K|WDR47_ENST00000369965.4_Missense_Mutation_p.Q452K			O94967	WDR47_HUMAN	WD repeat domain 47	451										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		AACATCTGTTGGTATATCTGC	0.408000													23	1002					0.00047179	0.00970853	0.00047179	1	0
JPH1	56704	broad.mit.edu	37	8	75227805	75227805	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:75227805G>A	ENST00000342232.4	-	2	470	c.430C>T	c.(430-432)Cgc>Tgc	p.R144C		NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	144					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			ACGCTCTGGCGCACGCCGTAG	0.682000													7	33					0	0	0.000157383	0	0
MAGEB1	4112	broad.mit.edu	37	X	30268784	30268784	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:30268784C>T	ENST00000378981.3	+	4	495	c.174C>T	c.(172-174)ccC>ccT	p.P58P	MAGEB1_ENST00000397548.2_Silent_p.P58P|MAGEB1_ENST00000397550.1_Silent_p.P58P	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	58										NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						CTGGCATTCCCCAGAAGCCTC	0.567000													5	4					0	0	1.23904e-05	0	0
THADA	63892	broad.mit.edu	37	2	43625235	43625235	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:43625235G>A	ENST00000405006.4	-	29	4453	c.4102C>T	c.(4102-4104)Cgt>Tgt	p.R1368C	THADA_ENST00000485353.1_5'UTR|THADA_ENST00000330266.7_Intron|THADA_ENST00000415080.2_Missense_Mutation_p.R1049C|THADA_ENST00000405975.2_Missense_Mutation_p.R1368C	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1368							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				ACCAAGGCACGAGCTGCCATT	0.468000													81	178					0	0	0.000147903	0	0
KIAA1551	55196	broad.mit.edu	37	12	32135922	32135922	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:32135922C>T	ENST00000312561.4	+	4	2447	c.2033C>T	c.(2032-2034)tCc>tTc	p.S678F	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		ACCTGTCTTTCCCTGTGGAAA	0.423000													23	25					0	0	0.000375601	0	0
KCNIP1	30820	broad.mit.edu	37	5	170145872	170145872	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:170145872C>T	ENST00000328939.4	+	2	709	c.172C>T	c.(172-174)Cga>Tga	p.R58*	KCNIP1_ENST00000520740.1_Nonsense_Mutation_p.R30*|KCNIP1_ENST00000390656.4_Nonsense_Mutation_p.R58*|KCNIP1_ENST00000377360.4_Nonsense_Mutation_p.R67*|KCNIP1_ENST00000411494.1_Nonsense_Mutation_p.R69*|KCNIP1_ENST00000434108.1_Nonsense_Mutation_p.R58*	NM_001034837.1|NM_014592.2	NP_001030009.1|NP_055407.1	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1	69	EF-hand 1; degenerate.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity	p.R69*(1)		autonomic_ganglia(1)|large_intestine(7)|lung(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	18	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGTCCTTTATCGAGGCTTCAA	0.587000													15	37					0	0	0.000422831	0	0
OR2G3	81469	broad.mit.edu	37	1	247769589	247769589	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:247769589G>A	ENST00000320002.2	+	1	734	c.702G>A	c.(700-702)agG>agA	p.R234R	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TAGAGGCAAGGCACAAAGCCT	0.468000													6	26					0	0	3.59834e-05	0	0
ZFHX4	79776	broad.mit.edu	37	8	77616627	77616627	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:77616627A>C	ENST00000521891.2	+	2	752	c.304A>C	c.(304-306)Aat>Cat	p.N102H	ZFHX4_ENST00000518282.1_Missense_Mutation_p.N102H|ZFHX4_ENST00000455469.2_Missense_Mutation_p.N102H|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000050961.6_Missense_Mutation_p.N102H	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	102						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCACTGCCCTAATGCCCGCCT	0.507000										HNSCC(33;0.089)			19	212					0	0	0.000375601	0	0
TPX2	22974	broad.mit.edu	37	20	30345338	30345338	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:30345338C>T	ENST00000340513.4	+	3	587	c.59C>T	c.(58-60)tCa>tTa	p.S20L	TPX2_ENST00000300403.6_Missense_Mutation_p.S20L			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	20					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			ATCAATTTTTCATCCTTGGAT	0.403000													14	74					0	0	0.000308642	0	0
DGKI	9162	broad.mit.edu	37	7	137257540	137257540	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:137257540G>A	ENST00000453654.1	-	18	1445	c.906C>T	c.(904-906)ttC>ttT	p.F302F	DGKI_ENST00000288490.5_Silent_p.F602F|DGKI_ENST00000446122.1_Silent_p.F602F|DGKI_ENST00000424189.2_Silent_p.F602F			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	602					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						CTATACACTGGAACTTCAGTT	0.373000													74	72					0	0	0.000147903	0	0
APC	324	broad.mit.edu	37	5	112178058	112178058	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:112178058C>T	ENST00000457016.1	+	16	7147	c.6767C>T	c.(6766-6768)cCa>cTa	p.P2256L	APC_ENST00000508376.2_Missense_Mutation_p.P2256L|CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Missense_Mutation_p.P2256L			P25054	APC_HUMAN	adenomatous polyposis coli	2256	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CTTAAGACTCCAGCCTCCAAA	0.478000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			21	29					0	0	0.000295444	0	0
FARP1	10160	broad.mit.edu	37	13	99063075	99063075	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr13:99063075T>C	ENST00000376586.2	+	15	2026	c.1690T>C	c.(1690-1692)Tcg>Ccg	p.S564P	FARP1_ENST00000595437.1_Missense_Mutation_p.S564P|FARP1_ENST00000319562.6_Missense_Mutation_p.S564P			Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	564	DH.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(3)|endometrium(6)|kidney(6)|large_intestine(13)|lung(16)|ovary(1)|skin(3)|urinary_tract(1)	49	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AGTTATCACTTCGGTATGTGC	0.423000													3	19					0	0	6.4e-05	0	0
VTA1	51534	broad.mit.edu	37	6	142519717	142519717	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:142519717C>T	ENST00000367630.4	+	6	720	c.662C>T	c.(661-663)cCa>cTa	p.P221L	VTA1_ENST00000452973.2_Missense_Mutation_p.P163L|VTA1_ENST00000491881.1_3'UTR|VTA1_ENST00000367621.1_Missense_Mutation_p.P163L	NM_016485.3	NP_057569.2	Q9NP79	VTA1_HUMAN	vesicle (multivesicular body) trafficking 1	221	Interaction with VPS4B (By similarity).				cellular membrane organization|endosome transport|protein transport	cytosol|endosome membrane	protein binding			endometrium(2)|large_intestine(1)|lung(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;1.34e-05)|GBM - Glioblastoma multiforme(68;0.00182)		GCACACGCTCCAGCTAATACA	0.433000													9	33					0	0	3.86212e-05	0	0
LPA	4018	broad.mit.edu	37	6	160962176	160962176	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:160962176G>A	ENST00000447678.1	-	36	5677	c.5557C>T	c.(5557-5559)Cca>Tca	p.P1853S	LPA_ENST00000484276.1_5'UTR|LPA_ENST00000316300.5_Missense_Mutation_p.P1853S	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4361	Kringle 17.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ACCCACTCTGGGGATATTAAG	0.443000													17	53					0	0	0.000375601	0	0
RIMS2	9699	broad.mit.edu	37	8	104948865	104948865	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:104948865G>A	ENST00000507740.1	+	10	2074	c.1838G>A	c.(1837-1839)cGa>cAa	p.R613Q	RIMS2_ENST00000406091.3_Missense_Mutation_p.R821Q|RIMS2_ENST00000436393.2_Missense_Mutation_p.R599Q|RIMS2_ENST00000262231.10_Missense_Mutation_p.R660Q	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	883					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.R613Q(3)|p.R888Q(3)|p.R599Q(3)		NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCAGTCCACCGAAGAGAATTT	0.388000										HNSCC(12;0.0054)			43	124					0	0	0.000437636	0	0
TIPIN	54962	broad.mit.edu	37	15	66641719	66641719	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:66641719G>A	ENST00000261881.4	-	5	430	c.345C>T	c.(343-345)ttC>ttT	p.F115F	TIPIN_ENST00000367709.4_Silent_p.F14F	NM_017858.2	NP_060328.2	Q9BVW5	TIPIN_HUMAN	TIMELESS interacting protein	115	Interaction with TIMELESS.				cell division|DNA replication checkpoint|intra-S DNA damage checkpoint|mitosis|positive regulation of cell proliferation|regulation of DNA replication involved in S phase|replication fork protection	cytoplasm|nuclear chromatin	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	7						GCAGTTTAGGGAATAGCCTAT	0.378000													16	176					0	0	0.000308642	0	0
PPFIA1	8500	broad.mit.edu	37	11	70171109	70171109	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:70171109G>T	ENST00000253925.7	+	4	738	c.523G>T	c.(523-525)Gat>Tat	p.D175Y	AP000487.6_ENST00000528607.1_RNA|CTA-797E19.2_ENST00000526017.1_RNA|PPFIA1_ENST00000389547.3_Missense_Mutation_p.D175Y	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	175					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CAAAGCTCTGGATGAAAAGGT	0.473000													21	82					6.12954e-19	1.29685e-17	9.22233e-05	1	0
ZYX	7791	broad.mit.edu	37	7	143080209	143080209	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:143080209T>G	ENST00000322764.5	+	5	1162	c.817T>G	c.(817-819)Ttt>Gtt	p.F273V	ZYX_ENST00000392910.2_Missense_Mutation_p.F116V|ZYX_ENST00000449423.2_Missense_Mutation_p.F186V|ZYX_ENST00000477373.1_3'UTR	NM_001010972.1|NM_003461.4	NP_001010972.1|NP_003452.1	Q15942	ZYX_HUMAN	zyxin	273					cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)	17	Melanoma(164;0.205)					GACTCCTAAGTTTACTCCTGT	0.577000													12	202					0	0	6.40141e-05	0	0
ASTN1	460	broad.mit.edu	37	1	176838053	176838053	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:176838053G>A	ENST00000367654.2	-	22	3611	c.3598C>T	c.(3598-3600)Ctc>Ttc	p.L1200F	ASTN1_ENST00000361833.2_Missense_Mutation_p.L1192F|ASTN1_ENST00000424564.2_Missense_Mutation_p.L1192F|ASTN1_ENST00000367657.3_Missense_Mutation_p.L1192F			O14525	ASTN1_HUMAN	astrotactin 1	1200					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						TAGTGGTAGAGGACCCGGTGT	0.493000													5	45					0	0	3.59834e-05	0	0
ANK2	287	broad.mit.edu	37	4	114279405	114279405	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:114279405G>A	ENST00000357077.4	+	38	9684	c.9631G>A	c.(9631-9633)Gaa>Aaa	p.E3211K	ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.E3178K|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3178					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGCCTCCACTGAAACACCTAC	0.488000													6	18					0	0	8.12818e-05	0	0
PLXNA2	5362	broad.mit.edu	37	1	208383671	208383671	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:208383671C>T	ENST00000367033.3	-	3	2082	c.1325G>A	c.(1324-1326)gGc>gAc	p.G442D		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	442	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		CACGCTGTAGCCGTTGTAAAC	0.542000													7	29					0	0	0.000274275	0	0
LRRC8A	56262	broad.mit.edu	37	9	131669672	131669672	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:131669672C>T	ENST00000259324.5	+	3	752	c.229C>T	c.(229-231)Ccg>Tcg	p.P77S	LRRC8A_ENST00000372599.3_Missense_Mutation_p.P77S|LRRC8A_ENST00000372600.4_Missense_Mutation_p.P77S	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	77					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						AGCCCCTGGCCCGGAGCCCAC	0.612000													6	29					0	0	8.12818e-05	0	0
C20orf196	149840	broad.mit.edu	37	20	5843845	5843845	+	Silent	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:5843845T>G	ENST00000303142.6	+	3	441	c.354T>G	c.(352-354)tcT>tcG	p.S118S		NM_152504.2	NP_689717.2	Q8IYI0	CT196_HUMAN	chromosome 20 open reading frame 196	118										endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|stomach(1)	9						ACTCACTCTCTGCATCTGTCT	0.498000													6	55					0	0	0.000442599	0	0
LEPR	3953	broad.mit.edu	37	1	66087038	66087038	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:66087038G>A	ENST00000349533.6	+	18	2679	c.2494G>A	c.(2494-2496)Gat>Aat	p.D832N	LEPR_ENST00000344610.8_Missense_Mutation_p.D832N|LEPR_ENST00000371058.1_Missense_Mutation_p.D832N|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371059.3_Missense_Mutation_p.D832N|LEPR_ENST00000371060.3_Missense_Mutation_p.D832N	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	832					energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TTTTTCAGATGATATTGAAAA	0.289000													34	37					0	0	0.000132358	0	0
GC	2638	broad.mit.edu	37	4	72618257	72618257	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:72618257G>A	ENST00000273951.8	-	11	1716	c.1373C>T	c.(1372-1374)cCt>cTt	p.P458L	GC_ENST00000503472.1_5'UTR|GC_ENST00000504199.1_Missense_Mutation_p.P477L|GC_ENST00000513476.1_Missense_Mutation_p.P458L	NM_000583.3|NM_001204306.1	NP_000574.2|NP_001191235.1	P02774	VTDB_HUMAN	group-specific component (vitamin D binding protein)	458	Albumin 3.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	45		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	GTAAAGAGGAGGTGAGTTTAT	0.438000													4	27					0	0	0.00024832	0	0
C5orf58	133874	broad.mit.edu	37	5	169661161	169661161	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:169661161C>T	ENST00000521850.1	+	1	1711	c.22C>T	c.(22-24)Ctc>Ttc	p.L8F	C5orf58_ENST00000517575.1_Intron|C5orf58_ENST00000593851.1_Missense_Mutation_p.L8F			C9J3I9	CE058_HUMAN	chromosome 5 open reading frame 58	8										large_intestine(1)|lung(4)|urinary_tract(1)	6						TGCAGAAATTCTCCCTGCTCA	0.408000													20	74					0	0	0.000175454	0	0
RP1L1	94137	broad.mit.edu	37	8	10470537	10470537	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:10470537G>A	ENST00000382483.3	-	4	1294	c.1071C>T	c.(1069-1071)ccC>ccT	p.P357P		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	357					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCCCCAGAACGGGGTCTTCCC	0.677000													16	41					0	0	0.000422831	0	0
MUC5AC	4586	broad.mit.edu	37	11	1156652	1156652	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:1156652C>T	ENST00000356191.2	+	10	661	c.661C>T	c.(661-663)Cct>Tct	p.P221S						mucin 5AC, oligomeric mucus/gel-forming											NS(1)|breast(2)|central_nervous_system(7)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(5)|kidney(9)|large_intestine(19)|liver(1)|lung(89)|ovary(7)|prostate(8)|skin(9)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	203		all_cancers(49;2.94e-05)|Breast(177;0.00257)|all_epithelial(84;0.00314)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.00146)|Lung(200;0.0612)|LUSC - Lung squamous cell carcinoma(625;0.0724)		TCAGCGAGCTCCTCTCCCACA	0.612000													9	18					0	0	0.000442599	0	0
WBSCR17	64409	broad.mit.edu	37	7	71175784	71175784	+	Silent	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:71175784T>C	ENST00000333538.5	+	10	2173	c.1539T>C	c.(1537-1539)ggT>ggC	p.G513G	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	513	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.G513G(1)		NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TGCACTTGGGTGCCCTGGGGA	0.622000													20	63					0	0	7.16444e-05	0	0
WDR6	11180	broad.mit.edu	37	3	49050863	49050863	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:49050863C>T	ENST00000395474.3	+	2	2266	c.1986C>T	c.(1984-1986)ttC>ttT	p.F662F	WDR6_ENST00000448293.1_Silent_p.F581F|WDR6_ENST00000415265.2_Silent_p.F80F	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	632					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		TCCTGGGTTTCCATGCCAATG	0.567000													5	32					0	0	1.23904e-05	0	0
MYH1	4619	broad.mit.edu	37	17	10401064	10401064	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:10401064C>T	ENST00000226207.5	-	31	4446	c.4352G>A	c.(4351-4353)aGg>aAg	p.R1451K	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1451				R -> T (in Ref. 4; CAA27380).		muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						ATCAAAGTTCCTTTGCTTTTT	0.443000													18	58					0	0	0.000175454	0	0
COL4A1	1282	broad.mit.edu	37	13	110847425	110847425	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr13:110847425C>T	ENST00000375820.4	-	22	1447	c.1326G>A	c.(1324-1326)caG>caA	p.Q442Q	COL4A1_ENST00000543140.1_Silent_p.Q442Q	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	442	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CAGGAGGACCCTGGTCACCTG	0.433000													15	79					0	0	0.000132079	0	0
CDH19	28513	broad.mit.edu	37	18	64218473	64218473	+	Missense_Mutation	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr18:64218473T>A	ENST00000262150.2	-	5	925	c.633A>T	c.(631-633)aaA>aaT	p.K211N	CDH19_ENST00000540086.1_Missense_Mutation_p.K211N	NM_021153.2	NP_066976.1	Q9H159	CAD19_HUMAN	cadherin 19, type 2	211	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				CTCTATCCATTTTAGAAGATA	0.313000													29	59					0	0	0.000109025	0	0
RAB5B	5869	broad.mit.edu	37	12	56383810	56383810	+	Silent	SNP	A	A	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:56383810A>G	ENST00000360299.5	+	3	464	c.243A>G	c.(241-243)cgA>cgG	p.R81R	RAB5B_ENST00000448789.2_Silent_p.R81R|RAB5B_ENST00000553116.1_Silent_p.R81R	NM_002868.3	NP_002859.1	P61020	RAB5B_HUMAN	RAB5B, member RAS oncogene family	81					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|membrane fraction|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity			endometrium(1)|large_intestine(1)|liver(2)|lung(4)|upper_aerodigestive_tract(1)	9			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.235)			GGCAGGAGCGATATCACAGCT	0.502000													27	38					0	0	7.16444e-05	0	0
DZIP3	9666	broad.mit.edu	37	3	108351803	108351803	+	Missense_Mutation	SNP	C	C	T	rs147130794		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:108351803C>T	ENST00000361582.3	+	9	930	c.700C>T	c.(700-702)Ctt>Ttt	p.L234F	DZIP3_ENST00000463306.1_Missense_Mutation_p.L234F	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	234					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						AATCTAGGATCTTCTTAATAA	0.294000													28	113					0	0	0.000147802	0	0
STAU1	6780	broad.mit.edu	37	20	47734876	47734876	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:47734876C>T	ENST00000371828.3	-	10	1445	c.958G>A	c.(958-960)Ggg>Agg	p.G320R	STAU1_ENST00000371792.1_Missense_Mutation_p.G312R|STAU1_ENST00000371802.1_Missense_Mutation_p.G320R|STAU1_ENST00000360426.4_Missense_Mutation_p.G314R|STAU1_ENST00000340954.7_Missense_Mutation_p.G314R|STAU1_ENST00000371856.2_Missense_Mutation_p.G395R|STAU1_ENST00000347458.5_Missense_Mutation_p.G314R	NM_001037328.1|NM_004602.2	NP_001032405.1|NP_004593.2	O95793	STAU1_HUMAN	staufen double-stranded RNA binding protein 1	395	DRBM 3.					microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|liver(1)|lung(6)|ovary(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	23			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			TTACTAGTCCCATTTTCATCC	0.438000													24	40					0	0	0.000117367	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94650952	94650952	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:94650952C>T	ENST00000260526.6	-	17	2048	c.1866G>A	c.(1864-1866)acG>acA	p.T622T	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	622					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity	p.T622T(1)		NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CCCTACATTTCGTGGGGGATC	0.398000													7	85					0	0	0.000157383	0	0
CHD9	80205	broad.mit.edu	37	16	53337980	53337980	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:53337980T>C	ENST00000566029.1	+	31	6271	c.6062T>C	c.(6061-6063)gTa>gCa	p.V2021A	CHD9_ENST00000447540.1_Missense_Mutation_p.V2021A|CHD9_ENST00000564845.1_Missense_Mutation_p.V2021A|CHD9_ENST00000398510.3_Missense_Mutation_p.V2021A			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2021					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				CAATATCAAGTAGCACTTTCT	0.413000													18	44					0	0	9.7654e-05	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307431	39307431	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:39307431G>A	ENST00000541347.1	-	2	809	c.570C>T	c.(568-570)ctC>ctT	p.L190L	CX3CR1_ENST00000399220.2_Silent_p.L190L|CX3CR1_ENST00000358309.3_Silent_p.L222L|CX3CR1_ENST00000542107.1_Silent_p.L190L	NM_001171171.1	NP_001164642.1	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	190					cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		CCACATTGCGGAGCACGGGCC	0.483000													10	133					0	0	0.00010058	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306825	2306825	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:2306825G>A	ENST00000290974.2	-	8	1581	c.1242C>T	c.(1240-1242)gcC>gcT	p.A414A	RP11-478C1.7_ENST00000510632.1_RNA|ZFYVE28_ENST00000515312.1_Silent_p.A344A|ZFYVE28_ENST00000511071.1_Silent_p.A384A	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	414					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						ACTCGGGCCTGGCCAGGGCTT	0.697000													8	68					0	0	0.000157383	0	0
FNDC1	84624	broad.mit.edu	37	6	159654273	159654273	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:159654273G>A	ENST00000297267.9	+	11	2929	c.2729G>A	c.(2728-2730)aGg>aAg	p.R910K	FNDC1_ENST00000340366.6_Missense_Mutation_p.R847K	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	910						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GAGGACTTAAGGAGAAGCCCG	0.612000													5	10					0	0	1.23904e-05	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128977597	128977597	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:128977597G>A	ENST00000274487.4	+	11	1943	c.1798G>A	c.(1798-1800)Gaa>Aaa	p.E600K	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	600	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		AGGTGAGAAAGAATGCAGAAC	0.388000													9	38					0	0	3.86212e-05	0	0
SSX3	10214	broad.mit.edu	37	X	48213512	48213512	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:48213512G>A	ENST00000298396.2	-	4	254	c.202C>T	c.(202-204)Cca>Tca	p.P68S	SSX3_ENST00000376893.3_Missense_Mutation_p.P68S	NM_021014.2	NP_066294.1	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3	68	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|large_intestine(1)|lung(9)	13						ATGAAAGATGGGAGGATGGCC	0.468000													17	29					0	0	9.7654e-05	0	0
COL14A1	7373	broad.mit.edu	37	8	121357718	121357718	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:121357718C>T	ENST00000297848.3	+	45	5263	c.4993C>T	c.(4993-4995)Cct>Tct	p.P1665S	COL14A1_ENST00000309791.4_Missense_Mutation_p.P1665S|COL14A1_ENST00000247781.3_Missense_Mutation_p.P1570S	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1665	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GCCAGGCTCACCTGGAGCCCC	0.647000													21	52					0	0	0.00047179	0	0
TCF4	6925	broad.mit.edu	37	18	53254312	53254312	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr18:53254312C>T	ENST00000354452.3	-	2	647	c.36G>A	c.(34-36)acG>acA	p.T12T	TCF4_ENST00000566286.1_Intron|TCF4_ENST00000565018.2_Silent_p.T12T|TCF4_ENST00000564999.1_Silent_p.T12T|TCF4_ENST00000564403.2_Silent_p.T12T|TCF4_ENST00000567880.1_Silent_p.T12T|TCF4_ENST00000356073.4_Silent_p.T12T|TCF4_ENST00000537578.1_Intron|TCF4_ENST00000568740.1_Intron|TCF4_ENST00000398339.1_Silent_p.T114T|TCF4_ENST00000566279.1_Silent_p.T12T	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	12	Essential for MYOD1 inhibition (By similarity).				positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		GCTCTTTGTCCGTCCCTAAGG	0.408000													12	73					0	0	0.000151284	0	0
GRIK1	2897	broad.mit.edu	37	21	31023548	31023548	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr21:31023548G>A	ENST00000399914.1	-	6	1365	c.844C>T	c.(844-846)Ctg>Ttg	p.L282L	GRIK1_ENST00000399913.1_Silent_p.L282L|GRIK1_ENST00000399907.1_Silent_p.L282L|GRIK1_ENST00000309434.7_Silent_p.L282L|GRIK1_ENST00000389125.3_Silent_p.L282L|GRIK1_ENST00000399909.1_Silent_p.L282L|GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000327783.4_Silent_p.L282L|GRIK1_ENST00000535441.1_Silent_p.L282L|GRIK1_ENST00000389124.2_Silent_p.L282L			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	282					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	ATGTTAAGCAGCCGAAACCCG	0.478000													17	26					0	0	0.000422831	0	0
SYNCRIP	10492	broad.mit.edu	37	6	86324795	86324795	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:86324795G>A	ENST00000503906.1	-	1	157	c.158C>T	c.(157-159)cCc>cTc	p.P53L	SYNCRIP_ENST00000355238.6_Silent_p.P517P|SYNCRIP_ENST00000369622.3_Silent_p.P517P																							CTCTACCGCGGGGAGGAGCAG	0.577000													20	32					0	0	0.000229342	0	0
KLHL13	90293	broad.mit.edu	37	X	117053616	117053616	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:117053616C>T	ENST00000371876.1	-	3	2706	c.285G>A	c.(283-285)agG>agA	p.R95R	KLHL13_ENST00000371878.1_Silent_p.R95R|KLHL13_ENST00000541812.1_Silent_p.R130R|KLHL13_ENST00000262820.3_Silent_p.R146R|KLHL13_ENST00000540167.1_Silent_p.R130R|KLHL13_ENST00000545703.1_Silent_p.R104R|KLHL13_ENST00000371882.1_Silent_p.R95R|KLHL13_ENST00000539496.1_Silent_p.R149R|KLHL13_ENST00000469946.1_Silent_p.R95R			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	146	BTB.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						CAATAATTTTCCTTAGACCGA	0.353000													51	27					0	0	0.000147903	0	0
ITIH2	3698	broad.mit.edu	37	10	7769746	7769746	+	Missense_Mutation	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:7769746T>A	ENST00000358415.4	+	11	1400	c.1234T>A	c.(1234-1236)Tcc>Acc	p.S412T	ITIH2_ENST00000379587.4_Missense_Mutation_p.S401T	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	412	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						AGACCCCAACTCCGTCTCGCT	0.438000													18	20					0	0	7.07596e-05	0	0
KCNK5	8645	broad.mit.edu	37	6	39162039	39162039	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:39162039G>A	ENST00000359534.3	-	4	878	c.540C>T	c.(538-540)ttC>ttT	p.F180F		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	180					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						CCATGAATACGAAGGGTGGGA	0.572000													11	40					0	0	6.40141e-05	0	0
DSP	1832	broad.mit.edu	37	6	7583465	7583465	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:7583465C>T	ENST00000379802.3	+	24	6311	c.5970C>T	c.(5968-5970)acC>acT	p.T1990T	DSP_ENST00000418664.2_Silent_p.T1391T	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1990	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ACAAAACAACCTTGGACAAAC	0.498000													12	51					0	0	0.00010058	0	0
MYH2	4620	broad.mit.edu	37	17	10428104	10428104	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:10428104C>T	ENST00000245503.5	-	34	5325	c.4941G>A	c.(4939-4941)agG>agA	p.R1647R	CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Silent_p.R1647R|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000581304.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1647					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TCCTGTAGTTCCTCAGGGCCT	0.502000													17	69					0	0	0.000132079	0	0
FSIP2	401024	broad.mit.edu	37	2	186671662	186671662	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:186671662G>A	ENST00000343098.5	+	17	17896	c.17896G>A	c.(17896-17898)Gaa>Aaa	p.E5966K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E5877K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						AACTACAGATGAAGCACCATC	0.383000													10	3					0	0	3.86212e-05	0	0
MTMR7	9108	broad.mit.edu	37	8	17157596	17157596	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:17157596C>T	ENST00000180173.5	-	14	1792	c.1758G>A	c.(1756-1758)atG>atA	p.M586I	MTMR7_ENST00000398099.3_Missense_Mutation_p.M177I|VPS37A_ENST00000521162.1_3'UTR	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	586							protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		GAAATGATTTCATATTCCCAC	0.468000													43	69					0	0	0.000147903	0	0
PAPPA	5069	broad.mit.edu	37	9	119094741	119094741	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:119094741G>A	ENST00000328252.3	+	12	3760	c.3391G>A	c.(3391-3393)Gat>Aat	p.D1131N	PAPPA_ENST00000534838.1_Missense_Mutation_p.D169N	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1131					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						TCAGAGCCACGATCTAGGTAA	0.493000													7	42					0	0	0.000442599	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136709	40136709	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:40136709G>A	ENST00000278198.2	-	2	3097	c.1134C>T	c.(1132-1134)tcC>tcT	p.S378S	LRRC4C_ENST00000527150.1_Silent_p.S378S|LRRC4C_ENST00000530763.1_Silent_p.S378S|LRRC4C_ENST00000528697.1_Silent_p.S378S			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	378	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				TCAGGGATGTGGAGGCCCGAC	0.502000													15	63					0	0	0.000308642	0	0
RBP3	5949	broad.mit.edu	37	10	48389376	48389376	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:48389376G>A	ENST00000224600.4	-	1	1615	c.1502C>T	c.(1501-1503)gCc>gTc	p.A501V		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	501	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CACGGGGCCGGCCTCAGGGCC	0.642000													11	15					0	0	0.000151284	0	0
HERC2P2	400322	broad.mit.edu	37	15	23311893	23311893	+	RNA	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:23311893G>A	ENST00000560464.1	-	0	3266																											AGGGCACAGGGAAGGGAGACG	0.652000													5	4					0	0	3.59834e-05	0	0
CDH16	1014	broad.mit.edu	37	16	66948256	66948256	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:66948256C>T	ENST00000299752.4	-	7	836	c.643G>A	c.(643-645)Gac>Aac	p.D215N	CDH16_ENST00000570262.1_Missense_Mutation_p.D135N|CDH16_ENST00000568632.1_Intron|CDH16_ENST00000565796.1_Missense_Mutation_p.D215N|CDH16_ENST00000394055.3_Missense_Mutation_p.D215N	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	215	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		TCACCCATGTCCTTGACCTGT	0.612000													5	36					0	0	3.59834e-05	0	0
UNC5D	137970	broad.mit.edu	37	8	35606138	35606138	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:35606138C>T	ENST00000287272.2	+	11	1673	c.1653C>T	c.(1651-1653)atC>atT	p.I551I	UNC5D_ENST00000416672.1_Silent_p.I625I|UNC5D_ENST00000453357.2_Silent_p.I615I|UNC5D_ENST00000420357.1_Silent_p.I553I|UNC5D_ENST00000404895.2_Silent_p.I620I|UNC5D_ENST00000449677.1_Silent_p.I196I			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	620	ZU5.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CATTGACCATCCCGCACTGTG	0.498000													14	111					0	0	5.01169e-05	0	0
FOXI1	2299	broad.mit.edu	37	5	169535068	169535068	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:169535068G>A	ENST00000306268.6	+	2	651	c.590G>A	c.(589-591)tGg>tAg	p.W197*	FOXI1_ENST00000449804.2_Intron			Q12951	FOXI1_HUMAN	forkhead box I1	197					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGGAATTACTGGACCCTGGAC	0.438000									Pendred syndrome				30	35					0	0	0.000109025	0	0
ERCC2	2068	broad.mit.edu	37	19	45855565	45855565	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:45855565G>A	ENST00000391945.4	-	22	2169	c.2092C>T	c.(2092-2094)Cag>Tag	p.Q698*	ERCC2_ENST00000391944.3_Nonsense_Mutation_p.Q620*	NM_000400.3	NP_000391.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	698					cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		AGGTGCTCCTGGATCCAGCGG	0.657000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				7	46					0	0	0.000442599	0	0
NUP160	23279	broad.mit.edu	37	11	47825067	47825067	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:47825067G>A	ENST00000378460.2	-	22	2744	c.2698C>T	c.(2698-2700)Ccc>Tcc	p.P900S	NUP160_ENST00000528071.1_Missense_Mutation_p.P786S|NUP160_ENST00000530326.1_Missense_Mutation_p.P786S	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	900					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						TGACACCAGGGATGTAGCAGT	0.378000													43	48					0	0	0.000147903	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54930890	54930890	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:54930890C>T	ENST00000474759.1	+	26	2409	c.2361C>T	c.(2359-2361)ttC>ttT	p.F787F	CACNA2D3-AS1_ENST00000471265.1_RNA|CACNA2D3_ENST00000490478.1_Silent_p.F693F|CACNA2D3_ENST00000288197.5_Silent_p.F787F|CACNA2D3_ENST00000415676.2_Silent_p.F787F	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	787						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CGATCCCATTCAGCACTGGTG	0.567000													7	68					0	0	0.000157383	0	0
TRPC7	57113	broad.mit.edu	37	5	135587547	135587547	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:135587547C>T	ENST00000513104.1	-	6	1651	c.1369G>A	c.(1369-1371)Gaa>Aaa	p.E457K	TRPC7_ENST00000426057.2_Missense_Mutation_p.E341K|TRPC7_ENST00000355180.3_Missense_Mutation_p.E396K	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	457					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCCCAGATTTCCTTGCATTCG	0.542000													8	33					0	0	0.000274275	0	0
NLRP5	126206	broad.mit.edu	37	19	56565166	56565166	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:56565166G>A	ENST00000390649.3	+	13	3291	c.3291G>A	c.(3289-3291)gcG>gcA	p.A1097A		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	1097			A -> T (in dbSNP:rs3103057).			mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GTGTTCTGGCGAGACTCGGGT	0.607000													13	53					0	0	7.07596e-05	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68044880	68044880	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:68044880C>T	ENST00000329153.5	+	19	2847	c.2715C>T	c.(2713-2715)acC>acT	p.T905T		NM_020715.2	NP_065766.1	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	905	MyTH4.					cytoskeleton	binding			endometrium(2)|kidney(4)|lung(12)|urinary_tract(1)	19				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		TGAAGCAGACCAGCTGCCGCC	0.612000													6	35					0	0	8.12818e-05	0	0
ARHGAP28	79822	broad.mit.edu	37	18	6873748	6873748	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr18:6873748G>A	ENST00000419673.2	+	8	926	c.709G>A	c.(709-711)Gtg>Atg	p.V237M	ARHGAP28_ENST00000532996.1_Missense_Mutation_p.V219M|ARHGAP28_ENST00000262227.3_Missense_Mutation_p.V344M|ARHGAP28_ENST00000314319.3_Missense_Mutation_p.V237M|ARHGAP28_ENST00000383472.4_Missense_Mutation_p.V396M|RP11-146G7.2_ENST00000583659.1_RNA|ARHGAP28_ENST00000418986.1_Missense_Mutation_p.V237M|ARHGAP28_ENST00000531294.1_Missense_Mutation_p.V232M|ARHGAP28_ENST00000400091.2_Missense_Mutation_p.V396M	NM_001010000.2	NP_001010000.1	B4DXL2	B4DXL2_HUMAN	Rho GTPase activating protein 28	219					signal transduction	intracellular				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	37		Colorectal(10;0.168)				AGACCCTGGAGTGAAAGTTCC	0.428000													6	15					0	0	3.59834e-05	0	0
TEX264	51368	broad.mit.edu	37	3	51737762	51737762	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:51737762G>A	ENST00000415259.1	+	5	1753	c.672G>A	c.(670-672)acG>acA	p.T224T	TEX264_ENST00000457573.1_Silent_p.T224T|TEX264_ENST00000395057.1_Silent_p.T224T|TEX264_ENST00000463857.1_3'UTR|TEX264_ENST00000341333.5_Silent_p.T224T|TEX264_ENST00000416589.1_Silent_p.T224T			Q9Y6I9	TX264_HUMAN	testis expressed 264	224						extracellular region				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(193;8.53e-05)|Kidney(197;0.000594)|KIRC - Kidney renal clear cell carcinoma(197;0.000759)		TGAGTGACACGAGTTCTGTAA	0.607000													98	78					0	0	0.000147903	0	0
DEFB119	245932	broad.mit.edu	37	20	29965226	29965226	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:29965226A>G	ENST00000339144.3	-	3	224	c.118T>C	c.(118-120)Tcg>Ccg	p.S40P	DEFB119_ENST00000376321.3_Silent_p.L26L|DEFB119_ENST00000492344.1_5'UTR			Q8N690	DB119_HUMAN	defensin, beta 119	0					defense response to bacterium	extracellular region				large_intestine(2)|lung(1)|prostate(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CCATGCATCGAAGGATGTGGC	0.428000													14	76					0	0	0.000422831	0	0
ZSCAN31	64288	broad.mit.edu	37	6	28294168	28294168	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:28294168G>A	ENST00000414429.1	-	8	1899	c.996C>T	c.(994-996)ttC>ttT	p.F332F	ZSCAN31_ENST00000439158.1_Silent_p.F332F|ZSCAN31_ENST00000344279.6_Silent_p.F332F|ZSCAN31_ENST00000481934.1_5'UTR|ZSCAN31_ENST00000396838.2_Silent_p.F332F|ZSCAN31_ENST00000446474.1_Silent_p.F173F					zinc finger and SCAN domain containing 31																		AGCTGAGGAGGAAAGCCTTCC	0.507000													30	102					0	0	0.000409698	0	0
MDS2	259283	broad.mit.edu	37	1	23965716	23965716	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:23965716C>T	ENST00000374555.3	+	5	708	c.121C>T	c.(121-123)Ctt>Ttt	p.L41F	MDS2_ENST00000477916.1_Intron					myelodysplastic syndrome 2 translocation associated											breast(1)|ovary(2)	3						TCTCTCCAAGCTTCCCACCAG	0.453000			T	ETV6	MDS								5	28					0	0	1.23904e-05	0	0
ERCC4	2072	broad.mit.edu	37	16	14041989	14041989	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:14041989C>T	ENST00000311895.7	+	11	2545	c.2536C>T	c.(2536-2538)Cct>Tct	p.P846S		NM_005236.2	NP_005227.1	Q92889	XPF_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 4	846	Interaction with EME1 and ERCC1.				double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(5)|lung(12)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	38						GAAGTATAATCCTGGTCCCCA	0.498000			"""Mis, N, F"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				6	39					0	0	3.59834e-05	0	0
HYDIN	54768	broad.mit.edu	37	16	71025223	71025223	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:71025223C>T	ENST00000393567.2	-	25	4012	c.3862G>A	c.(3862-3864)Gat>Aat	p.D1288N		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1288										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CACCGTACATCTGAGATCACA	0.473000													5	24					0	0	3.59834e-05	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077497	19077497	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:19077497G>A	ENST00000329773.2	-	2	540	c.453C>T	c.(451-453)gtC>gtT	p.V151V		NM_054030.2	NP_473371.1	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	151					sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			NS(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	15						CCCAGAGCAGGACACACACGA	0.582000													18	39					0	0	7.07596e-05	0	0
USP7	7874	broad.mit.edu	37	16	8995010	8995010	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:8995010G>A	ENST00000344836.4	-	19	2327	c.2129C>T	c.(2128-2130)tCc>tTc	p.S710F	USP7_ENST00000535863.1_Missense_Mutation_p.S611F|USP7_ENST00000381886.4_Missense_Mutation_p.S694F	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	710	Interaction with ICP0/VMW110.				interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						TATTTTACAGGATATTGGTGT	0.358000													12	78					0	0	0.000219431	0	0
TRIM60	166655	broad.mit.edu	37	4	165961536	165961536	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:165961536G>A	ENST00000512596.1	+	3	528	c.312G>A	c.(310-312)ctG>ctA	p.L104L	TRIM60_ENST00000341062.5_Silent_p.L104L|TRIM60_ENST00000508504.1_Silent_p.L104L	NM_152620.2	NP_689833.1	Q495X7	TRI60_HUMAN	tripartite motif containing 60	104						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	29	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		ACCAGTTTCTGACCCTCTTCT	0.408000													5	29					0	0	1.23904e-05	0	0
LRRC4B	94030	broad.mit.edu	37	19	51022237	51022237	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:51022237G>A	ENST00000599957.1	-	3	930	c.733C>T	c.(733-735)Cgc>Tgc	p.R245C	LRRC4B_ENST00000389201.3_Missense_Mutation_p.R245C			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	245						cell junction|integral to membrane|presynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		GAGCCCGGGCGGATCAGGTCC	0.657000													5	8					0	0	1.23904e-05	0	0
ITPR1	3708	broad.mit.edu	37	3	4829669	4829669	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:4829669T>G	ENST00000354582.6	+	51	6959	c.6609T>G	c.(6607-6609)ttT>ttG	p.F2203L	ITPR1_ENST00000456211.2_Missense_Mutation_p.F2155L|ITPR1_ENST00000443694.2_Missense_Mutation_p.F2203L|ITPR1_ENST00000423119.2_Missense_Mutation_p.F2170L|ITPR1_ENST00000357086.4_Missense_Mutation_p.F2170L|ITPR1_ENST00000302640.8_Missense_Mutation_p.F2203L|ITPR1_ENST00000544951.1_Intron			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2218					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AGATAGTCTTTCCCGTGCCCA	0.358000													6	39					0	0	0.000157383	0	0
PCIF1	63935	broad.mit.edu	37	20	44567907	44567907	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:44567907C>T	ENST00000372409.3	+	4	542	c.178C>T	c.(178-180)Ccc>Tcc	p.P60S		NM_022104.3	NP_071387.1	Q9H4Z3	PCIF1_HUMAN	PDX1 C-terminal inhibiting factor 1	60	WW.					nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	20						GGAGAATCGTCCCTACTACTT	0.627000													25	29					0	0	0.000147802	0	0
ASB10	136371	broad.mit.edu	37	7	150878530	150878530	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:150878530G>A	ENST00000422024.1	-	3	860	c.735C>T	c.(733-735)ctC>ctT	p.L245L	ASB10_ENST00000420175.2_Silent_p.L200L|ASB10_ENST00000275838.1_Silent_p.L200L|ASB10_ENST00000434669.1_Silent_p.L245L|ASB10_ENST00000377867.3_Silent_p.L185L	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	200					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAAACCTGAGGAGCAGCTCCG	0.632000													4	19					0	0	3.59834e-05	0	0
PHF8	23133	broad.mit.edu	37	X	54011586	54011586	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:54011586G>A	ENST00000338154.6	-	18	2708	c.2204C>T	c.(2203-2205)tCg>tTg	p.S735L	PHF8_ENST00000357988.5_Missense_Mutation_p.S771L|PHF8_ENST00000338946.6_Missense_Mutation_p.S634L|PHF8_ENST00000322659.8_Missense_Mutation_p.S718L	NM_015107.2	NP_055922.1	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	771					brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	40						CGGTGAGGACGATGAGGACTG	0.612000													4	2					0	0	1.23904e-05	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281176	49281176	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr13:49281176G>A	ENST00000282018.3	+	1	226	c.223G>A	c.(223-225)Gtt>Att	p.V75I		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	75					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	ATCTGTGAACGTTTTCATGCT	0.408000													10	29					0	0	0.00010058	0	0
DOCK2	1794	broad.mit.edu	37	5	169186739	169186739	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:169186739C>T	ENST00000256935.8	+	24	2487	c.2407C>T	c.(2407-2409)Ctg>Ttg	p.L803L	DOCK2_ENST00000520908.1_Silent_p.L295L|DOCK2_ENST00000540750.1_5'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	803					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCATCTGTCCTGCATGATGT	0.453000													25	72					0	0	0.000227799	0	0
SPINK13	153218	broad.mit.edu	37	5	147649650	147649650	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:147649650C>T	ENST00000512953.1	+	3	546	c.15C>T	c.(13-15)ccC>ccT	p.P5P	RP11-373N22.3_ENST00000501695.3_RNA|SPINK13_ENST00000398450.4_Silent_p.P5P|SPINK13_ENST00000511106.1_5'UTR			Q1W4C9	ISK13_HUMAN	serine peptidase inhibitor, Kazal type 13 (putative)	5						extracellular region	serine-type endopeptidase inhibitor activity			breast(2)|lung(3)	5						CTGCCTTTCCCCACAAGATTA	0.398000													61	84					0	0	0.000147903	0	0
HAUS8	93323	broad.mit.edu	37	19	17160816	17160816	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:17160816G>A	ENST00000593360.1	-	10	2935	c.917C>T	c.(916-918)tCt>tTt	p.S306F	HAUS8_ENST00000448593.2_Missense_Mutation_p.S366F|HAUS8_ENST00000253669.5_Missense_Mutation_p.S367F			Q9BT25	HAUS8_HUMAN	HAUS augmin-like complex, subunit 8	367					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)	12						GTCGTCCTCAGACAGGGGCGT	0.617000													10	27					0	0	6.40141e-05	0	0
MMRN2	79812	broad.mit.edu	37	10	88702347	88702347	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:88702347C>T	ENST00000372027.4	-	6	2267	c.2194G>A	c.(2194-2196)Ggc>Agc	p.G732S		NM_024756.2	NP_079032.2	Q9H8L6	MMRN2_HUMAN	multimerin 2	732						extracellular space				breast(1)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|stomach(1)	19						TTGTGGAGGCCGTGAAGGGAG	0.662000													10	18					0	0	6.40141e-05	0	0
IGHG4	3503	broad.mit.edu	37	14	106091232	106091232	+	RNA	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:106091232C>T	ENST00000390543.2	-	0	661																											GTGGGTCCCACCTTTGGCTTT	0.617000													19	117					0	0	0.000175454	0	0
IL12RB1	3594	broad.mit.edu	37	19	18186603	18186603	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:18186603C>T	ENST00000600835.1	-	8	959	c.656G>A	c.(655-657)gGa>gAa	p.G219E	IL12RB1_ENST00000430026.2_Missense_Mutation_p.G219E|IL12RB1_ENST00000593993.1_Missense_Mutation_p.G219E|IL12RB1_ENST00000322153.6_Missense_Mutation_p.G219E			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	219	Fibronectin type-III 2.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CCAGGAACTTCCTTGGCTCCC	0.587000													12	55					0	0	0.00010058	0	0
USP29	57663	broad.mit.edu	37	19	57641395	57641395	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:57641395A>C	ENST00000254181.4	+	4	1806	c.1352A>C	c.(1351-1353)aAt>aCt	p.N451T	USP29_ENST00000598197.1_Missense_Mutation_p.N451T	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	451					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTAGAACCTAATAATTATCTC	0.358000													35	159					0	0	0.000228196	0	0
ATP2B1	490	broad.mit.edu	37	12	90024357	90024357	+	Missense_Mutation	SNP	C	C	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:90024357C>G	ENST00000428670.3	-	6	1309	c.853G>C	c.(853-855)Gga>Cga	p.G285R	ATP2B1_ENST00000359142.3_Missense_Mutation_p.G285R|ATP2B1_ENST00000261173.2_Missense_Mutation_p.G285R|ATP2B1_ENST00000348959.3_Missense_Mutation_p.G285R|ATP2B1_ENST00000393164.2_Missense_Mutation_p.G28R			P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	285					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						AAGATAATTCCAGTTTGAGAA	0.323000													10	59					0	0	6.40141e-05	0	0
SQLE	6713	broad.mit.edu	37	8	126021462	126021462	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:126021462C>T	ENST00000265896.5	+	6	1883	c.985C>T	c.(985-987)Ccg>Tcg	p.P329S	SQLE_ENST00000523430.1_Missense_Mutation_p.P234S	NM_003129.3	NP_003120.2	Q14534	ERG1_HUMAN	squalene epoxidase	329					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome	flavin adenine dinucleotide binding|squalene monooxygenase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	14	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)		Butenafine(DB01091)|Naftifine(DB00735)|Terbinafine(DB00857)	TTTAGCTAACCCGAGTCCAGT	0.323000													53	218					0	0	0.000147903	0	0
ZPLD1	131368	broad.mit.edu	37	3	102176628	102176628	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:102176628C>T	ENST00000306176.1	+	5	661	c.561C>T	c.(559-561)tcC>tcT	p.S187S	ZPLD1_ENST00000466937.1_Silent_p.S171S|ZPLD1_ENST00000491959.1_Silent_p.S171S	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	171	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						GTTTTAGGTCCTCAGCGGCTA	0.363000													46	147					0	0	0.000147903	0	0
CABIN1	23523	broad.mit.edu	37	22	24483564	24483564	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:24483564C>T	ENST00000398319.2	+	23	3808	c.3423C>T	c.(3421-3423)tcC>tcT	p.S1141S	CABIN1_ENST00000405822.2_Silent_p.S1091S|CABIN1_ENST00000263119.5_Silent_p.S1141S	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1141					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						CCAACTTGTCCCTATGGATTG	0.562000													21	66					0	0	0.00047179	0	0
CSMD1	64478	broad.mit.edu	37	8	2815330	2815330	+	Splice_Site	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:2815330C>T	ENST00000520002.1	-	64	10261		c.e64-1		CSMD1_ENST00000537824.1_Splice_Site|CSMD1_ENST00000602723.1_Splice_Site|CSMD1_ENST00000542608.1_Splice_Site|CSMD1_ENST00000400186.3_Splice_Site|CSMD1_ENST00000602557.1_Splice_Site			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1							integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCTTCCAACCTAGAGAGGAA	0.458000													3	5					0	0	6.4e-05	0	0
LPAL2	80350	broad.mit.edu	37	6	160932074	160932074	+	RNA	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:160932074C>T	ENST00000335388.5	-	0	82					NR_028092.1															large_intestine(1)|lung(4)	5		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		GAAAGTGTGTCCCAATCCCAG	0.418000													66	74					0	0	0.000147903	0	0
SNHG14	104472715	broad.mit.edu	37	15	25230395	25230395	+	RNA	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:25230395C>T	ENST00000551631.2	+	0	887				SNHG14_ENST00000551361.1_RNA	NR_001293.1																						ATGGTTTTTCCTATCAGTACA	0.368000													12	15					0	0	6.40141e-05	0	0
SERPINA6	866	broad.mit.edu	37	14	94780794	94780794	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:94780794G>A	ENST00000341584.3	-	2	338	c.192C>T	c.(190-192)ttC>ttT	p.F64F		NM_001756.3	NP_001747.2	P08185	CBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	64					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	26		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	CAGGGGAGATGAAAATGTTCT	0.552000													8	27					0	0	0.000157383	0	0
PYHIN1	149628	broad.mit.edu	37	1	158911905	158911905	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:158911905C>T	ENST00000368140.1	+	5	963	c.718C>T	c.(718-720)Cat>Tat	p.H240Y	PYHIN1_ENST00000392252.3_Missense_Mutation_p.H231Y|PYHIN1_ENST00000485134.1_3'UTR|PYHIN1_ENST00000368138.3_Missense_Mutation_p.H231Y|PYHIN1_ENST00000392254.2_Missense_Mutation_p.H240Y	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	240	HIN-200.				cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					AAGAATGTTTCATGCTACAGT	0.318000													17	40					0	0	0.000229342	0	0
GPR50	9248	broad.mit.edu	37	X	150348464	150348464	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:150348464G>A	ENST00000218316.3	+	2	478	c.409G>A	c.(409-411)Gaa>Aaa	p.E137K		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	137					cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCAGTACGAACGGATCTT	0.542000													28	14					0	0	0.000147802	0	0
BRD8	10902	broad.mit.edu	37	5	137476450	137476450	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:137476450G>A	ENST00000254900.5	-	26	3930	c.3559C>T	c.(3559-3561)Cat>Tat	p.H1187Y		NM_139199.1	NP_631938.1	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	1187	Bromo 2.				cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TATACATGATGATCAGAGTCA	0.463000													97	231					0	0	0.000147903	0	0
ERCC6	2074	broad.mit.edu	37	10	50681610	50681610	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:50681610G>A	ENST00000355832.5	-	14	2700	c.2622C>T	c.(2620-2622)ttC>ttT	p.F874F	ERCC6_ENST00000542458.1_Silent_p.F244F	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	874	Helicase C-terminal.				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						GGGCTCTAAGGAATACTTCAA	0.413000								Direct reversal of damage;Nucleotide excision repair (NER)					41	65					0	0	0.000147903	0	0
OR13C2	392376	broad.mit.edu	37	9	107367329	107367329	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:107367329C>T	ENST00000542196.1	-	1	622	c.580G>A	c.(580-582)Gac>Aac	p.D194N		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						AACTCATTGTCTGAGATGTCA	0.388000													12	57					0	0	0.000219431	0	0
SIRPB1	10326	broad.mit.edu	37	20	1559046	1559046	+	Missense_Mutation	SNP	C	C	T	rs145977289	byFrequency	TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:1559046C>T	ENST00000381605.4	-	2	435	c.371G>A	c.(370-372)cGg>cAg	p.R124Q	SIRPB1_ENST00000262929.5_Missense_Mutation_p.R123Q|RP4-576H24.4_ENST00000564763.1_Missense_Mutation_p.R124Q|SIRPB1_ENST00000381603.3_Missense_Mutation_p.R124Q	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	124	Ig-like V-type.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						GCTCCCTTTCCGGAACTTCAC	0.542000													37	69					0	0	0.000270559	0	0
SP140L	93349	broad.mit.edu	37	2	231236359	231236359	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:231236359G>A	ENST00000243810.6	+	7	630	c.630G>A	c.(628-630)agG>agA	p.R210R	SP140L_ENST00000458341.1_Silent_p.R123R|SP140L_ENST00000444636.1_Silent_p.R210R|SP140L_ENST00000415673.2_Silent_p.R210R|SP140L_ENST00000396563.4_Silent_p.R210R			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	210						nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						AACCCAAGAGGAAAAGAAGTA	0.279000													13	39					0	0	0.000219431	0	0
C5	727	broad.mit.edu	37	9	123742403	123742403	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:123742403G>A	ENST00000223642.1	-	28	3645	c.3616C>T	c.(3616-3618)Cgt>Tgt	p.R1206C		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1206					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	ACAATTGAACGAAACTGTGGG	0.408000													16	74					0	0	0.000229342	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291305	141291305	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:141291305C>T	ENST00000247452.3	-	3	816	c.469G>A	c.(469-471)Gaa>Aaa	p.E157K		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	157	MAGE.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCTGCTTCGTATTTGAGG	0.478000										HNSCC(46;0.14)			42	76					0	0	0.000437636	0	0
DOCK10	55619	broad.mit.edu	37	2	225666651	225666651	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:225666651A>C	ENST00000409592.3	-	40	4470	c.4357T>G	c.(4357-4359)Tta>Gta	p.L1453V	DOCK10_ENST00000258390.7_Missense_Mutation_p.L1459V			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1459							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		GTATTGTCTAACATCTGTAAG	0.383000													25	33					0	0	0.000117367	0	0
SNF8	11267	broad.mit.edu	37	17	47021290	47021290	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:47021290G>A	ENST00000502492.1	-	2	484	c.102C>T	c.(100-102)gcC>gcT	p.A34A	SNF8_ENST00000290330.3_Silent_p.A34A			Q96H20	SNF8_HUMAN	SNF8, ESCRT-II complex subunit	34					cellular membrane organization|endosome transport|protein transport|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytosol|late endosome membrane|transcription factor complex	transcription factor binding			breast(1)|endometrium(1)|lung(1)	3						GACTTACCTGGGCTAGCTGGT	0.557000													19	57					0	0	0.00047179	0	0
OR11H4	390442	broad.mit.edu	37	14	20711839	20711839	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:20711839C>T	ENST00000315409.2	+	1	942	c.889C>T	c.(889-891)Cct>Tct	p.P297S		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P297A(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		TCTTTTTAATCCTCTGATCTA	0.398000													19	72					0	0	0.000132079	0	0
PRDM12	59335	broad.mit.edu	37	9	133543670	133543670	+	Silent	SNP	C	C	T	rs145300834	byFrequency	TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:133543670C>T	ENST00000253008.2	+	3	600	c.540C>T	c.(538-540)atC>atT	p.I180I		NM_021619.2	NP_067632.2	Q9H4Q4	PRD12_HUMAN	PR domain containing 12	180	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.I180I(1)		kidney(2)|large_intestine(3)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		TGGTCCAGATCGGCACCAGCA	0.587000													7	50					0	0	0.000274275	0	0
IL7R	3575	broad.mit.edu	37	5	35873713	35873713	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:35873713T>G	ENST00000303115.3	+	5	798	c.669T>G	c.(667-669)agT>agG	p.S223R	IL7R_ENST00000506850.1_Missense_Mutation_p.S223R|IL7R_ENST00000343305.4_Missense_Mutation_p.S223R	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	223	Fibronectin type-III.				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GGAGTCCAAGTTATTACTTCA	0.433000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						10	58					0	0	0.00010058	0	0
WDR72	256764	broad.mit.edu	37	15	53908429	53908429	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:53908429G>A	ENST00000396328.1	-	15	2213	c.1974C>T	c.(1972-1974)gcC>gcT	p.A658A	WDR72_ENST00000559418.1_Silent_p.A668A|WDR72_ENST00000557913.1_Silent_p.A655A|WDR72_ENST00000360509.5_Silent_p.A658A	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	658								p.A658A(1)		NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		GGCAAAATTTGGCATCAGTAA	0.318000													8	13					0	0	0.000442599	0	0
MAGEA6	4105	broad.mit.edu	37	X	151870060	151870060	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:151870060C>T	ENST00000329342.5	+	3	975	c.750C>T	c.(748-750)ttC>ttT	p.F250F		NM_005363.2	NP_005354.1	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	250	MAGE.						protein binding			breast(1)|endometrium(3)|large_intestine(3)|lung(16)|prostate(3)|skin(1)|urinary_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					CCCAATATTTCGTGCAGGAAA	0.537000													24	39					0	0	0.000295444	0	0
ALPPL2	251	broad.mit.edu	37	2	233273284	233273284	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:233273284G>A	ENST00000295453.3	+	7	908		c.e7+1			NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2						phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CATCTCATGGGTAATGACCCC	0.657000													8	28					0	0	0.00010058	0	0
TMEM119	338773	broad.mit.edu	37	12	108985573	108985573	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:108985573C>T	ENST00000392806.3	-	2	755	c.587G>A	c.(586-588)gGa>gAa	p.G196E		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	196						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						CATCCTGGCTCCGTCCCCACC	0.677000													16	13					0	0	5.01169e-05	0	0
MRPS2	51116	broad.mit.edu	37	9	138393782	138393782	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:138393782C>T	ENST00000371785.1	+	4	471	c.262C>T	c.(262-264)Cga>Tga	p.R88*	MRPS2_ENST00000488610.1_3'UTR|MRPS2_ENST00000241600.5_Nonsense_Mutation_p.R88*			Q9Y399	RT02_HUMAN	mitochondrial ribosomal protein S2	88					translation	mitochondrion|small ribosomal subunit	structural constituent of ribosome			large_intestine(2)|lung(1)|prostate(2)|urinary_tract(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.46e-53)|Epithelial(140;2.04e-47)|all cancers(34;1.23e-42)		CTTCGATGCCCGAGTCCATCT	0.552000													26	38					0	0	0.000227799	0	0
SVEP1	79987	broad.mit.edu	37	9	113205880	113205880	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:113205880G>A	ENST00000401783.2	-	27	4920	c.4584C>T	c.(4582-4584)atC>atT	p.I1528I	SVEP1_ENST00000302728.8_Silent_p.I1528I|SVEP1_ENST00000374469.1_Silent_p.I1505I|SVEP1_ENST00000467821.1_5'UTR	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1528	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						ATTTCCCATCGATATAGACTT	0.438000													13	21					0	0	0.000219431	0	0
SPTA1	6708	broad.mit.edu	37	1	158590199	158590199	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:158590199C>T	ENST00000368148.3	-	44	6358	c.6178G>A	c.(6178-6180)Gaa>Aaa	p.E2060K	SPTA1_ENST00000368147.3_Missense_Mutation_p.E2057K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2060					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCCATCTTTTCACACCAGTTG	0.468000													7	26					0	0	0.000274275	0	0
CASR	846	broad.mit.edu	37	3	121973162	121973162	+	Silent	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:121973162T>C	ENST00000498619.1	+	2	564	c.126T>C	c.(124-126)ttT>ttC	p.F42F	CASR_ENST00000296154.5_Silent_p.F42F|CASR_ENST00000490131.1_Silent_p.F42F	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	42					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CTATTCATTTTGGAGTAGCAG	0.507000													49	39					0	0	0.000147903	0	0
RBM11	54033	broad.mit.edu	37	21	15599508	15599508	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr21:15599508G>A	ENST00000400577.3	+	5	749	c.740G>A	c.(739-741)cGa>cAa	p.R247Q	RBM11_ENST00000468643.1_3'UTR	NM_144770.3	NP_658983.3	P57052	RBM11_HUMAN	RNA binding motif protein 11	247							nucleotide binding|RNA binding	p.R247Q(1)		endometrium(3)|kidney(3)|lung(7)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		ATGAATAAACGAAAGAGACAA	0.408000													52	97					0	0	0.000147903	0	0
AMDHD1	144193	broad.mit.edu	37	12	96354372	96354372	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:96354372G>A	ENST00000266736.2	+	5	890	c.784G>A	c.(784-786)Gat>Aat	p.D262N		NM_152435.2	NP_689648.2	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	262					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|skin(1)	22						CTTCCATGGGGATGAACTCCA	0.408000													44	89					0	0	0.000147903	0	0
XAB2	56949	broad.mit.edu	37	19	7689196	7689196	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:7689196C>T	ENST00000358368.4	-	7	995	c.958G>A	c.(958-960)Gag>Aag	p.E320K	XAB2_ENST00000534844.1_Missense_Mutation_p.E317K	NM_020196.2	NP_064581.2	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	320					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	26						CCCTCCTCCTCGCGCCCCAGC	0.647000								Direct reversal of damage;Nucleotide excision repair (NER)					12	51					0	0	0.000151284	0	0
TRPS1	7227	broad.mit.edu	37	8	116599467	116599467	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:116599467G>T	ENST00000395715.3	-	5	3038	c.2461C>A	c.(2461-2463)Caa>Aaa	p.Q821K	TRPS1_ENST00000220888.5_Missense_Mutation_p.Q808K|TRPS1_ENST00000520276.1_Missense_Mutation_p.Q812K|TRPS1_ENST00000519076.1_Missense_Mutation_p.Q562K|TRPS1_ENST00000519674.1_Missense_Mutation_p.Q808K	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	808					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AGGCTTGCTTGGGTGTATGAC	0.587000									Langer-Giedion syndrome				8	177					0.000442599	0.0091171	0.000442599	1	0
RYR2	6262	broad.mit.edu	37	1	237778068	237778068	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:237778068G>A	ENST00000366574.2	+	37	5957	c.5640G>A	c.(5638-5640)gaG>gaA	p.E1880E	RYR2_ENST00000542537.1_Silent_p.E1864E|RYR2_ENST00000360064.6_Silent_p.E1878E	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1880	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAGCTGGTGAGGAAGAAGCCA	0.537000													6	39					0	0	0.000157383	0	0
TBX18	9096	broad.mit.edu	37	6	85446592	85446592	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:85446592C>T	ENST00000369663.5	-	8	1972	c.1635G>A	c.(1633-1635)gaG>gaA	p.E545E	TBX18_ENST00000606784.1_Intron	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	545					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		AAACAATTTTCTCAGGACTGG	0.498000													17	48					0	0	0.000229342	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18691116	18691116	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:18691116C>T	ENST00000433979.1	+	24	3343	c.3227C>T	c.(3226-3228)tCa>tTa	p.S1076L	PIK3C2G_ENST00000538779.1_Missense_Mutation_p.S1117L|PIK3C2G_ENST00000266497.5_Missense_Mutation_p.S1076L	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1076	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				ATTTTTACTTCAGAGATGGAA	0.378000													6	8					0	0	3.59834e-05	0	0
MYH15	22989	broad.mit.edu	37	3	108183613	108183613	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:108183613C>T	ENST00000273353.3	-	16	1719	c.1663G>A	c.(1663-1665)Gct>Act	p.A555T		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	555	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						AGGTCTGTAGCCTTAGGAAAC	0.423000													5	48					0	0	3.59834e-05	0	0
OR14K1	343170	broad.mit.edu	37	1	247902441	247902441	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:247902441C>T	ENST00000283225.2	+	1	525	c.525C>T	c.(523-525)ttC>ttT	p.F175F	RP11-634B7.4_ENST00000449298.1_RNA					olfactory receptor, family 14, subfamily K, member 1											NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|lung(18)|ovary(1)|urinary_tract(1)	27						TACATCAGTTCTTCTGCGATG	0.463000													30	76					0	0	0.000491102	0	0
ZNF114	163071	broad.mit.edu	37	19	48789857	48789857	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:48789857C>T	ENST00000595607.1	+	6	1470	c.976C>T	c.(976-978)Cac>Tac	p.H326Y	ZNF114_ENST00000597695.1_Missense_Mutation_p.H292Y|ZNF114_ENST00000315849.1_Missense_Mutation_p.H326Y|ZNF114_ENST00000600687.1_Missense_Mutation_p.H326Y			Q8NC26	ZN114_HUMAN	zinc finger protein 114	326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)	18		all_epithelial(76;8.01e-05)|all_lung(116;0.000112)|Lung NSC(112;0.000192)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;7.56e-05)|all cancers(93;0.000113)|Epithelial(262;0.00962)|GBM - Glioblastoma multiforme(486;0.0153)		TATGAAAATTCACACTGGAGA	0.383000													25	116					0	0	7.16444e-05	0	0
SGK223	157285	broad.mit.edu	37	8	8185578	8185578	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:8185578C>T	ENST00000520004.1	-	5	2978	c.2714G>A	c.(2713-2715)aGc>aAc	p.S905N	SGK223_ENST00000330777.4_Missense_Mutation_p.S905N			Q86YV5	SG223_HUMAN		905							ATP binding|non-membrane spanning protein tyrosine kinase activity										GAGGCCAGGGCTCCCGCAGCC	0.657000													13	50					0	0	0.00010058	0	0
HOXB1	3211	broad.mit.edu	37	17	46607066	46607066	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:46607066C>T	ENST00000239174.6	-	2	841	c.749G>A	c.(748-750)tGg>tAg	p.W250*	HOXB1_ENST00000577092.1_3'UTR	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	250						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GTTCTGGAACCAAATCTTGAC	0.592000													92	58					0	0	0.000147903	0	0
FAM71B	153745	broad.mit.edu	37	5	156589674	156589674	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:156589674G>A	ENST00000302938.4	-	2	1697	c.1602C>T	c.(1600-1602)atC>atT	p.I534I		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	534						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AAAAAGAGCTGATCTTACTGG	0.478000													131	536					0	0	0.000147903	0	0
MTG2	26164	broad.mit.edu	37	20	60775817	60775817	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:60775817G>T	ENST00000370823.3	+	7	923	c.905G>T	c.(904-906)cGc>cTc	p.R302L	MTG2_ENST00000536470.1_Missense_Mutation_p.R74L|MTG2_ENST00000436421.2_Missense_Mutation_p.R144L	NM_015666.3	NP_056481.1			mitochondrial ribosome-associated GTPase 2																		CACATCGAGCGCTGCCGCTTT	0.567000													7	281					1.12685e-05	0.00023402	0.000274275	1	0
TMEM200A	114801	broad.mit.edu	37	6	130761889	130761889	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:130761889G>A	ENST00000392429.1	+	2	2700	c.322G>A	c.(322-324)Gaa>Aaa	p.E108K	TMEM200A_ENST00000545622.1_Missense_Mutation_p.E108K|TMEM200A_ENST00000296978.3_Missense_Mutation_p.E108K	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	108						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CATTCGGAATGAAGGCGGTGT	0.418000													10	48					0	0	3.86212e-05	0	0
ANKLE2	23141	broad.mit.edu	37	12	133324813	133324813	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:133324813C>T	ENST00000539605.1	-	3	7450	c.766G>A	c.(766-768)Gag>Aag	p.E256K	ANKLE2_ENST00000337516.5_Missense_Mutation_p.E318K|ANKLE2_ENST00000357997.5_Missense_Mutation_p.E318K			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	318						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		TCTCCCTTCTCCACAGCTTTC	0.532000													24	14					0	0	0.00047179	0	0
SEC14L4	284904	broad.mit.edu	37	22	30899737	30899737	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:30899737G>A	ENST00000255858.7	-	2	140	c.57C>T	c.(55-57)ttC>ttT	p.F19F	SEC14L4_ENST00000381982.3_Silent_p.F19F|SEC14L4_ENST00000392772.2_5'UTR|SEC14L4_ENST00000540456.1_5'UTR	NM_001161368.1|NM_174977.3	NP_001154840.1|NP_777637.1	Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	19						integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	GGTTCTCCCGGAACTGAGCGG	0.632000													11	28					0	0	0.00010058	0	0
TULP3	7289	broad.mit.edu	37	12	3030044	3030044	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:3030044C>T	ENST00000448120.2	+	3	260	c.209C>T	c.(208-210)cCc>cTc	p.P70L	TULP3_ENST00000397132.2_Missense_Mutation_p.P70L	NM_003324.4	NP_003315.2	O75386	TULP3_HUMAN	tubby like protein 3	70					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding			endometrium(1)|large_intestine(4)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GAGCAGACTCCCTTGGTGAAC	0.493000													39	23					0	0	0.000437636	0	0
WDR93	56964	broad.mit.edu	37	15	90276391	90276391	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:90276391C>T	ENST00000268130.7	+	13	1586	c.1485C>T	c.(1483-1485)tcC>tcT	p.S495S	WDR93_ENST00000560294.1_Silent_p.S467S|WDR93_ENST00000444934.2_Silent_p.S212S	NM_020212.1	NP_064597.1	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	495					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			NS(1)|breast(3)|endometrium(2)|kidney(4)|large_intestine(5)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	33	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			CAGACGCCTCCCTCCATCTGG	0.502000													19	57					0	0	9.7654e-05	0	0
FKBP8	23770	broad.mit.edu	37	19	18644121	18644121	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:18644121G>A	ENST00000597960.2	-	7	1102	c.982C>T	c.(982-984)Ccc>Tcc	p.P328S	FKBP8_ENST00000222308.3_Missense_Mutation_p.P328S|FKBP8_ENST00000544835.2_Missense_Mutation_p.P168S|FKBP8_ENST00000596558.1_Missense_Mutation_p.P327S|AC005387.2_ENST00000596596.1_RNA|FKBP8_ENST00000453489.2_Missense_Mutation_p.P356S			Q14318	FKBP8_HUMAN	FK506 binding protein 8, 38kDa	327					apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	15						CTCAGGATGGGGATGGCCTCA	0.622000													4	6					0	0	3.59834e-05	0	0
NLRP12	91662	broad.mit.edu	37	19	54312893	54312893	+	Missense_Mutation	SNP	C	C	T	rs139937024		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:54312893C>T	ENST00000324134.6	-	3	2188	c.2020G>A	c.(2020-2022)Ggg>Agg	p.G674R	NLRP12_ENST00000354278.3_Missense_Mutation_p.G674R|NLRP12_ENST00000351894.4_Missense_Mutation_p.G674R|NLRP12_ENST00000391775.3_Missense_Mutation_p.G674R|NLRP12_ENST00000345770.5_Missense_Mutation_p.G674R|NLRP12_ENST00000535162.1_Missense_Mutation_p.G674R|NLRP12_ENST00000391773.1_Missense_Mutation_p.G674R|NLRP12_ENST00000391772.1_Missense_Mutation_p.G674R	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	674					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding	p.G674W(1)		NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CGGTCTTCCCCGTCCGCGCTG	0.617000													6	24					0	0	8.12818e-05	0	0
NPY2R	4887	broad.mit.edu	37	4	156135711	156135711	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:156135711G>A	ENST00000329476.3	+	2	1109	c.620G>A	c.(619-621)tGg>tAg	p.W207*	NPY2R_ENST00000506608.1_Nonsense_Mutation_p.W207*	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	207					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				ACTGAAAAGTGGCCTGGCGAG	0.488000													34	65					0	0	0.000125731	0	0
BCL9	607	broad.mit.edu	37	1	147091993	147091993	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:147091993C>T	ENST00000234739.3	+	8	2772	c.2032C>T	c.(2032-2034)Cct>Tct	p.P678S		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	678	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					CCCCATTTTCCCTCGAATACC	0.562000			T	"""IGH@, IGL@"""	B-ALL								8	25					0	0	0.000442599	0	0
CALB1	793	broad.mit.edu	37	8	91072436	91072436	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:91072436C>T	ENST00000265431.3	-	11	932	c.751G>A	c.(751-753)Gat>Aat	p.D251N	CALB1_ENST00000518457.1_Missense_Mutation_p.D194N	NM_004929.2	NP_004920.1	P05937	CALB1_HUMAN	calbindin 1, 28kDa	251						nucleus	calcium ion binding|vitamin D binding			breast(1)|kidney(1)|lung(8)|pancreas(1)	11			BRCA - Breast invasive adenocarcinoma(11;0.00953)			AGAGCAAGATCCGTTCGGTAC	0.398000													15	106					0	0	7.07596e-05	0	0
IGHV1-2	28474	broad.mit.edu	37	14	106452801	106452801	+	RNA	SNP	C	C	T	rs11553007		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:106452801C>T	ENST00000390594.2	-	0	284																											TGTGCCACCACTGTTAGGGTT	0.552000													9	59					0	0	3.86212e-05	0	0
CSMD1	64478	broad.mit.edu	37	8	2944738	2944738	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:2944738C>T	ENST00000520002.1	-	50	7913	c.7358G>A	c.(7357-7359)gGa>gAa	p.G2453E	CSMD1_ENST00000537824.1_Missense_Mutation_p.G2452E|CSMD1_ENST00000602723.1_Missense_Mutation_p.G2453E|CSMD1_ENST00000542608.1_Missense_Mutation_p.G2452E|CSMD1_ENST00000400186.3_Missense_Mutation_p.G2453E|CSMD1_ENST00000602557.1_Missense_Mutation_p.G2453E			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2453	Sushi 14.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CACTTTGCTTCCAACCGCTCC	0.512000													8	74					0	0	0.000157383	0	0
AZI1	22994	broad.mit.edu	37	17	79164543	79164543	+	Silent	SNP	G	G	A	rs139538707		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:79164543G>A	ENST00000269392.4	-	24	3259	c.3012C>T	c.(3010-3012)ttC>ttT	p.F1004F	AZI1_ENST00000450824.2_Silent_p.F1001F|AZI1_ENST00000575907.1_Silent_p.F968F|AZI1_ENST00000374782.3_Silent_p.F965F	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	1004					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GCCGGTCCTCGAACTCCTGGC	0.687000													12	16					0	0	0.000219431	0	0
SEC16A	9919	broad.mit.edu	37	9	139371752	139371752	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:139371752G>A	ENST00000313050.7	-	1	389	c.316C>T	c.(316-318)Ccc>Tcc	p.P106S		NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	2070					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GGCTCACAGGGTCCCTGAGAG	0.587000													27	51					0	0	0.000184323	0	0
ANK3	288	broad.mit.edu	37	10	61802491	61802491	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:61802491C>T	ENST00000280772.1	-	43	13283	c.13092G>A	c.(13090-13092)acG>acA	p.T4364T	ANK3_ENST00000503366.1_Silent_p.T1855T|ANK3_ENST00000355288.2_Silent_p.T988T|ANK3_ENST00000373827.2_Silent_p.T1848T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4364					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTCTTTCTTCGTTTTCACCT	0.398000													26	71					0	0	0.000339439	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161019118	161019118	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:161019118C>A	ENST00000368013.3	-	12	2013	c.1693G>T	c.(1693-1695)Gag>Tag	p.E565*	ARHGAP30_ENST00000368016.3_Nonsense_Mutation_p.E565*|ARHGAP30_ENST00000368015.1_Nonsense_Mutation_p.E388*	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	565					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			ACAGAGAACTCCTCCACCTGT	0.622000													7	30					0.000274275	0.00566128	0.000274275	1	0
OR2M5	127059	broad.mit.edu	37	1	248309067	248309067	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:248309067G>A	ENST00000366476.1	+	1	618	c.618G>A	c.(616-618)atG>atA	p.M206I		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GTATAGTAATGATTGTTTTTC	0.408000													15	94					0	0	5.01169e-05	0	0
USH2A	7399	broad.mit.edu	37	1	215853584	215853584	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:215853584A>C	ENST00000366943.2	-	62	12587	c.12201T>G	c.(12199-12201)agT>agG	p.S4067R	USH2A_ENST00000307340.3_Missense_Mutation_p.S4067R			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4067	Fibronectin type-III 26.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTCTCAGTCCACTTGGGGAAG	0.423000										HNSCC(13;0.011)			8	74					0	0	0.000274275	0	0
FREM1	158326	broad.mit.edu	37	9	14863874	14863874	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:14863874C>T	ENST00000380881.4	-	4	1077	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K	FREM1_ENST00000422223.2_Missense_Mutation_p.E88K|FREM1_ENST00000380880.3_Missense_Mutation_p.E88K			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	88					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding	p.E88K(1)		breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TACTTGACTTCGTTGGGAAGG	0.413000													7	46					0	0	3.86212e-05	0	0
TRPC7	57113	broad.mit.edu	37	5	135692426	135692426	+	Missense_Mutation	SNP	G	G	A	rs138178870	by1000genomes	TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:135692426G>A	ENST00000513104.1	-	2	932	c.650C>T	c.(649-651)tCg>tTg	p.S217L	TRPC7_ENST00000426057.2_Missense_Mutation_p.S217L|TRPC7_ENST00000355180.3_Missense_Mutation_p.S217L	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	217					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTTCATGCGCGAGCGCGAGTG	0.612000													9	32					0	0	0.000274275	0	0
ZNF831	128611	broad.mit.edu	37	20	57782092	57782092	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:57782092G>A	ENST00000371030.2	+	3	4008	c.4008G>A	c.(4006-4008)caG>caA	p.Q1336Q		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1336						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CCCCTGGGCAGACCTCTTCAG	0.582000													12	52					0	0	0.000219431	0	0
OTUD6A	139562	broad.mit.edu	37	X	69283074	69283074	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:69283074G>A	ENST00000338352.2	+	1	734	c.700G>A	c.(700-702)Gag>Aag	p.E234K		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	234	OTU.									autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						GACCCCCATCGAGGTGATCCA	0.617000													11	6					0	0	6.40141e-05	0	0
IGKV1D-43	28891	broad.mit.edu	37	2	90249191	90249191	+	RNA	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:90249191G>A	ENST00000468879.1	+	0	328																											GGGCCAGTCAGGGCATTAGCA	0.498000													21	57					0	0	0.000229342	0	0
ZNF425	155054	broad.mit.edu	37	7	148802118	148802118	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:148802118G>A	ENST00000378061.2	-	4	977	c.845C>T	c.(844-846)aCc>aTc	p.T282I		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	282					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GTACCGGAAGGTCTTGTCGCA	0.637000													14	29					0	0	0.000308642	0	0
CA10	56934	broad.mit.edu	37	17	49710851	49710851	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:49710851T>G	ENST00000451037.2	-	8	1890	c.950A>C	c.(949-951)aAg>aCg	p.K317T	CA10_ENST00000285273.4_Missense_Mutation_p.K317T|CA10_ENST00000570565.1_Missense_Mutation_p.K242T|CA10_ENST00000340813.6_Missense_Mutation_p.K323T|CA10_ENST00000442502.2_Missense_Mutation_p.K317T	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	317					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			ATACTGAAGCTTCTGGGCTCG	0.507000													5	37					0	0	8.12818e-05	0	0
PCDHA13	56136	broad.mit.edu	37	5	140264055	140264055	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:140264055G>A	ENST00000289272.2	+	1	2202	c.2202G>A	c.(2200-2202)ccG>ccA	p.P734P	PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.P734P|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGCGCGCCGGGCAAGCCCA	0.682000													27	65					0	0	0.000191422	0	0
C9orf84	158401	broad.mit.edu	37	9	114454514	114454514	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:114454514G>A	ENST00000394779.3	-	23	3678	c.3434C>T	c.(3433-3435)tCa>tTa	p.S1145L	C9orf84_ENST00000318737.4_Missense_Mutation_p.S1184L|C9orf84_ENST00000394777.4_Missense_Mutation_p.S1110L|C9orf84_ENST00000374287.3_Missense_Mutation_p.S1184L	NM_001080551.1	NP_001074020.1	Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	1184										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						CTGATTGTATGAAGTCACAGG	0.373000													9	59					0	0	6.40141e-05	0	0
ATP12A	479	broad.mit.edu	37	13	25265365	25265365	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr13:25265365G>A	ENST00000218548.6	+	8	1396	c.1063G>A	c.(1063-1065)Gag>Aag	p.E355K	ATP12A_ENST00000381946.3_Missense_Mutation_p.E349K	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	349					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding	p.E349K(1)		breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CAATGTGCCCGAGGGCCTCCT	0.567000													7	17					0	0	3.86212e-05	0	0
MEF2C	4208	broad.mit.edu	37	5	88027647	88027647	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:88027647G>A	ENST00000504921.2	-	7	1381	c.709C>T	c.(709-711)Caa>Taa	p.Q237*	MEF2C_ENST00000424173.2_Nonsense_Mutation_p.Q235*|MEF2C_ENST00000340208.5_Nonsense_Mutation_p.Q255*|MEF2C_ENST00000437473.2_Nonsense_Mutation_p.Q237*|MEF2C_ENST00000514015.1_Nonsense_Mutation_p.Q237*|MEF2C_ENST00000506554.1_Nonsense_Mutation_p.Q237*|MEF2C_ENST00000508569.1_Nonsense_Mutation_p.Q237*|MEF2C_ENST00000510942.1_Nonsense_Mutation_p.Q237*|MEF2C_ENST00000514028.1_Nonsense_Mutation_p.Q237*|MEF2C_ENST00000539796.1_Nonsense_Mutation_p.Q189*			Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C	237					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	40		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		GATTTTGCTTGCATATTCTTG	0.433000										HNSCC(66;0.2)			5	23					0	0	1.23904e-05	0	0
KCNT2	343450	broad.mit.edu	37	1	196295984	196295984	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:196295984G>A	ENST00000367433.5	-	19	2240	c.2139C>T	c.(2137-2139)gcC>gcT	p.A713A	KCNT2_ENST00000294725.8_Silent_p.A713A|KCNT2_ENST00000367431.4_Silent_p.A663A|KCNT2_ENST00000451324.2_Silent_p.A324A|KCNT2_ENST00000498426.1_Intron			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	713						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TGAATCCATAGGCTTTTGCAT	0.318000													9	50					0	0	3.86212e-05	0	0
TRBV6-5	28602	broad.mit.edu	37	7	142180675	142180675	+	RNA	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:142180675G>A	ENST00000390368.2	-	0	249																											ATCAGCCTCAGCCCCATGCCT	0.507000													36	215					0	0	0.000106405	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30690047	30690047	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:30690047G>A	ENST00000215790.7	-	7	922	c.758C>T	c.(757-759)tCg>tTg	p.S253L	TBC1D10A_ENST00000403362.1_Missense_Mutation_p.S165L|TBC1D10A_ENST00000403477.3_Missense_Mutation_p.S260L|RP1-130H16.18_ENST00000447976.1_Missense_Mutation_p.S127L	NM_031937.2	NP_114143.1	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	253	Rab-GAP TBC.					intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						GGCCACCGGCGACACCTTCTG	0.612000													38	51					0	0	0.000228196	0	0
PSME3	10197	broad.mit.edu	37	17	40986569	40986569	+	Nonsense_Mutation	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:40986569T>G	ENST00000293362.3	+	3	274	c.113T>G	c.(112-114)tTa>tGa	p.L38*	PSME3_ENST00000592578.1_3'UTR|PSME3_ENST00000592169.1_Intron|PSME3_ENST00000441946.2_Nonsense_Mutation_p.L49*|PSME3_ENST00000590720.1_Nonsense_Mutation_p.L38*|PSME3_ENST00000545225.1_5'UTR|PSME3_ENST00000541124.1_3'UTR	NM_005789.3|NM_176863.2	NP_005780.2|NP_789839.1	P61289	PSME3_HUMAN	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	38					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome activator complex	endopeptidase activator activity|identical protein binding|MDM2 binding|p53 binding			NS(1)|cervix(1)|large_intestine(3)|lung(1)	6		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		CCAAAGAAGTTATTAGAACTT	0.398000													35	119					0	0	0.000106405	0	0
OR2W3	343171	broad.mit.edu	37	1	248059688	248059688	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:248059688C>T	ENST00000537741.1	+	3	1057	c.800C>T	c.(799-801)tCc>tTc	p.S267F	OR2W3_ENST00000360358.3_Missense_Mutation_p.S267F			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCCAGTTCTTCCCAGGACCAG	0.537000													31	39					0	0	8.91981e-05	0	0
IGHV3OR16-9	28307	broad.mit.edu	37	16	33647337	33647337	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:33647337G>A	ENST00000558425.1	-	2	262	c.263C>T	c.(262-264)aCc>aTc	p.T88I																								CCTGGAGATGGTGAATCGGCC	0.512000													92	131					0	0	0.000147903	0	0
CYP4F2	8529	broad.mit.edu	37	19	16006398	16006398	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:16006398G>A	ENST00000221700.5	-	3	356	c.261C>T	c.(259-261)ggC>ggT	p.G87G	CYP4F2_ENST00000592328.1_Intron|CYP4F2_ENST00000011989.7_Intron	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	87					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						AGACCTTAAAGCCCTGGGGGT	0.572000													35	46					0	0	0.000319135	0	0
GPR179	440435	broad.mit.edu	37	17	36483144	36483144	+	Missense_Mutation	SNP	G	G	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:36483144G>C	ENST00000342292.4	-	11	6328	c.6308C>G	c.(6307-6309)gCa>gGa	p.A2103G	GPR179_ENST00000584976.1_Intron	NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	2103						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				ACTGCCTGCTGCCTCAGAACT	0.602000													6	107					0	0	3.59834e-05	0	0
SFRP1	6422	broad.mit.edu	37	8	41166145	41166145	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:41166145G>A	ENST00000220772.3	-	1	871	c.534C>T	c.(532-534)tcC>tcT	p.S178S		NM_003012.4	NP_003003.3	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1	178					brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|liver(1)|lung(1)|skin(1)	7	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			CTTGGGGCTTGGAGGCTTCGG	0.677000													6	4					0	0	0.000157383	0	0
SLC14A2	8170	broad.mit.edu	37	18	43247925	43247925	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr18:43247925G>A	ENST00000255226.6	+	14	2661	c.1845G>A	c.(1843-1845)gcG>gcA	p.A615A	SLC14A2_ENST00000586448.1_Silent_p.A615A|SLC14A2_ENST00000589658.1_Silent_p.A92A	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	615						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CCTGGTGGGCGATCTCAGGCT	0.562000													15	50					0	0	0.000422831	0	0
MYH2	4620	broad.mit.edu	37	17	10438462	10438462	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:10438462C>T	ENST00000245503.5	-	19	2492	c.2108G>A	c.(2107-2109)gGt>gAt	p.G703D	CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.G703D|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000581304.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	703	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TTCCAGCACACCGTTACACCT	0.463000													18	25					0	0	5.01169e-05	0	0
KRTAP5-1	387264	broad.mit.edu	37	11	1605974	1605974	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:1605974G>A	ENST00000382171.2	-	1	539	c.506C>T	c.(505-507)tCt>tTt	p.S169F	KRTAP5-AS1_ENST00000532922.1_RNA|KRTAP5-AS1_ENST00000424148.1_RNA|KRTAP5-AS1_ENST00000534077.1_RNA|KRTAP5-AS1_ENST00000524947.1_RNA	NM_001005922.1	NP_001005922.1	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	169	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(3)|kidney(1)|lung(9)|skin(2)|upper_aerodigestive_tract(1)	16		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCCCCCACAAGAACCACAGGC	0.662000													17	28					0	0	5.01169e-05	0	0
AKAP11	11215	broad.mit.edu	37	13	42877183	42877183	+	Missense_Mutation	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr13:42877183T>A	ENST00000025301.2	+	8	4476	c.4301T>A	c.(4300-4302)tTt>tAt	p.F1434Y		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	1434					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		GAAGGTTACTTTTGTAAAAAT	0.353000													8	24					0	0	3.86212e-05	0	0
CD81-AS1	101927682	broad.mit.edu	37	11	2356804	2356804	+	RNA	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:2356804C>T	ENST00000413483.1	-	0	407				RPL26P30_ENST00000602923.1_RNA																							GTAGTGTCCTCGAACTACCTG	0.542000													7	69					0	0	0.000274275	0	0
ZNF75A	7627	broad.mit.edu	37	16	3367756	3367756	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:3367756C>T	ENST00000574298.1	+	6	1251	c.778C>T	c.(778-780)Ctt>Ttt	p.L260F	ZNF75A_ENST00000498240.2_3'UTR	NM_153028.2	NP_694573.1	Q96N20	ZN75A_HUMAN	zinc finger protein 75a	260					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(7)|prostate(1)	12						GAACTCCCACCTTATTAAACA	0.423000													5	39					0	0	8.12818e-05	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54905576	54905576	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:54905576G>A	ENST00000474759.1	+	18	1685	c.1637G>A	c.(1636-1638)gGa>gAa	p.G546E	CACNA2D3_ENST00000490478.1_Missense_Mutation_p.G452E|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.G546E|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.G546E	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	546	Cache.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TACGAAGAAGGAAAAAAGCGA	0.448000													12	50					0	0	0.000308642	0	0
KIAA0408	9729	broad.mit.edu	37	6	127768485	127768485	+	Missense_Mutation	SNP	C	C	T	rs142527882		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:127768485C>T	ENST00000483725.3	-	5	1315	c.979G>A	c.(979-981)Gaa>Aaa	p.E327K	SOGA3_ENST00000481848.2_3'UTR|SOGA3_ENST00000556132.1_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	327							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		GTTTTCCCTTCATTTGGATAC	0.418000													12	17					0	0	0.00010058	0	0
TDRD6	221400	broad.mit.edu	37	6	46659643	46659643	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:46659643G>T	ENST00000544460.1	+	1	4032	c.3778G>T	c.(3778-3780)Gaa>Taa	p.E1260*	TDRD6_ENST00000316081.6_Nonsense_Mutation_p.E1260*	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1260					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			AAAGAAAGAAGAAATTTCTGC	0.328000													8	120					0.000157383	0.00325516	0.000157383	1	0
LILRA2	11027	broad.mit.edu	37	19	55086778	55086778	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:55086778G>A	ENST00000251377.3	+	6	844	c.711G>A	c.(709-711)ggG>ggA	p.G237G	LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000251376.3_Silent_p.G237G|LILRA2_ENST00000391737.1_Silent_p.G225G|LILRA2_ENST00000391738.3_Silent_p.G237G|LILRB1_ENST00000448689.1_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		TGGCCCCCGGGGAGAGCCTGA	0.567000													14	70					0	0	9.7654e-05	0	0
ME3	10873	broad.mit.edu	37	11	86382865	86382865	+	Missense_Mutation	SNP	G	G	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:86382865G>C	ENST00000543262.1	-	2	448	c.122C>G	c.(121-123)gCg>gGg	p.A41G	ME3_ENST00000359636.2_Missense_Mutation_p.A41G|ME3_ENST00000393324.3_Missense_Mutation_p.A41G	NM_001161586.1	NP_001155058.1	Q16798	MAON_HUMAN	malic enzyme 3, NADP(+)-dependent, mitochondrial	41					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(2)|skin(3)|stomach(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	CACAGGGCGCGCCGGGCCAGG	0.726000													7	39					0	0	0.000442599	0	0
CRB1	23418	broad.mit.edu	37	1	197313541	197313541	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:197313541C>T	ENST00000367400.3	+	3	918	c.783C>T	c.(781-783)ctC>ctT	p.L261L	CRB1_ENST00000538660.1_Silent_p.L261L|CRB1_ENST00000543483.1_5'UTR|CRB1_ENST00000367399.2_Intron|CRB1_ENST00000535699.1_Silent_p.L192L	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	261					cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						ACTGTGAACTCAACACTGATG	0.517000													22	40					0	0	0.000229342	0	0
MAP3K5	4217	broad.mit.edu	37	6	136935337	136935337	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:136935337C>T	ENST00000359015.4	-	16	2598	c.2238G>A	c.(2236-2238)gaG>gaA	p.E746E	MAP3K5_ENST00000355845.4_5'UTR	NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	746	Protein kinase.				activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TGAAACCATTCTCACTGAAAG	0.393000													35	76					0	0	0.000491102	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77389917	77389917	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:77389917G>A	ENST00000282849.5	-	9	1798	c.1380C>T	c.(1378-1380)atC>atT	p.I460I		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	460	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TGGGAGACATGATATTGCCTT	0.448000													11	37					0	0	0.000219431	0	0
CDHR2	54825	broad.mit.edu	37	5	176011422	176011422	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:176011422G>A	ENST00000510636.1	+	19	2414	c.2140G>A	c.(2140-2142)Ggc>Agc	p.G714S	CDHR2_ENST00000506348.1_Missense_Mutation_p.G714S|CDHR2_ENST00000261944.5_Missense_Mutation_p.G714S	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	714	Cadherin 7.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						AGTGCTAGTGGGCGTGGTGAA	0.612000													20	60					0	0	0.000175454	0	0
MLIP	90523	broad.mit.edu	37	6	53986346	53986346	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:53986346C>T	ENST00000514921.1	+	2	278	c.165C>T	c.(163-165)ttC>ttT	p.F55F	MLIP_ENST00000370876.2_Intron|MLIP_ENST00000509997.1_Intron|MLIP_ENST00000358276.5_Silent_p.F49F|MLIP_ENST00000511744.1_3'UTR|MLIP_ENST00000502396.1_Silent_p.F66F|MLIP_ENST00000274897.5_Silent_p.F55F|MLIP_ENST00000370877.2_Intron			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	55						nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						CCTCTAAATTCCTTGTTAAAA	0.358000													15	78					0	0	0.000422831	0	0
SEMA6A	57556	broad.mit.edu	37	5	115813769	115813769	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:115813769G>A	ENST00000343348.6	-	14	2296	c.1509C>T	c.(1507-1509)ttC>ttT	p.F503F	CTB-118N6.3_ENST00000514214.1_RNA|SEMA6A_ENST00000257414.8_Silent_p.F503F|CTB-118N6.3_ENST00000508640.1_RNA|SEMA6A_ENST00000282394.6_Silent_p.F35F|CTB-118N6.3_ENST00000510682.1_RNA|SEMA6A_ENST00000510263.1_Silent_p.F503F	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	503	Sema.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		CACAGGTAGAGAACGCAACAT	0.448000													18	40					0	0	7.07596e-05	0	0
TOX2	84969	broad.mit.edu	37	20	42697310	42697310	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:42697310C>T	ENST00000358131.5	+	8	1659	c.1451C>T	c.(1450-1452)tCg>tTg	p.S484L	TOX2_ENST00000423191.1_Missense_Mutation_p.S460L|TOX2_ENST00000341197.3_Missense_Mutation_p.S502L|TOX2_ENST00000435864.2_Missense_Mutation_p.S380L|TOX2_ENST00000372999.1_Missense_Mutation_p.S460L	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	484					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			AGGGACAAATCGCTCTACCTC	0.627000													10	27					0	0	6.40141e-05	0	0
LRRC7	57554	broad.mit.edu	37	1	70503885	70503885	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:70503885C>T	ENST00000310961.5	+	22	2697	c.2279C>T	c.(2278-2280)cCt>cTt	p.P760L	LRRC7_ENST00000035383.5_Missense_Mutation_p.P755L|LRRC7_ENST00000415775.2_Missense_Mutation_p.P39L			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	755						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CCACAGCGTCCTGACCGGCTG	0.517000													60	105					0	0	0.000147903	0	0
LRRC49	54839	broad.mit.edu	37	15	71300792	71300792	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:71300792G>A	ENST00000260382.5	+	12	1504	c.1244G>A	c.(1243-1245)gGg>gAg	p.G415E	LRRC49_ENST00000560369.1_Missense_Mutation_p.G420E|LRRC49_ENST00000436542.2_3'UTR|LRRC49_ENST00000560158.2_Missense_Mutation_p.G103E|LRRC49_ENST00000544974.2_Missense_Mutation_p.G405E|LRRC49_ENST00000560691.1_Missense_Mutation_p.G121E|LRRC49_ENST00000443425.2_Missense_Mutation_p.G371E	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	415						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						GAAGTGGACGGGGATACACTT	0.423000													10	47					0	0	0.000442599	0	0
ZNF618	114991	broad.mit.edu	37	9	116811415	116811415	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:116811415C>T	ENST00000288466.7	+	14	1653	c.1554C>T	c.(1552-1554)atC>atT	p.I518I	ZNF618_ENST00000374126.5_Silent_p.I611I|ZNF618_ENST00000470105.1_3'UTR	NM_133374.2	NP_588615.2	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	611					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.I611I(1)|p.I518I(1)		breast(1)|endometrium(4)|lung(10)|urinary_tract(1)	16						TGTCGGAGATCAGGACAGTGT	0.607000													24	70					0	0	0.000227799	0	0
CCDC180	100499483	broad.mit.edu	37	9	100116955	100116955	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:100116955T>C	ENST00000375202.2	+	37	4591	c.3239T>C	c.(3238-3240)aTg>aCg	p.M1080T	CCDC180_ENST00000529487.1_Missense_Mutation_p.M1080T|RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000395220.1_3'UTR|CCDC180_ENST00000357054.1_Missense_Mutation_p.M1051T					coiled-coil domain containing 180																		AGTGTCATCATGCTCAACATG	0.522000													19	50					0	0	0.000132079	0	0
BCLAF1	9774	broad.mit.edu	37	6	136593187	136593187	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:136593187C>T	ENST00000531224.1	-	8	2241	c.1989G>A	c.(1987-1989)agG>agA	p.R663R	BCLAF1_ENST00000527759.1_Silent_p.R661R|BCLAF1_ENST00000353331.4_Silent_p.R661R|BCLAF1_ENST00000530767.1_Silent_p.R490R|BCLAF1_ENST00000527536.1_Silent_p.R663R|BCLAF1_ENST00000392348.2_Silent_p.R661R	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	663					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GGGTATGCTTCCTCAGGGTAC	0.303000													5	38					0	0	3.59834e-05	0	0
MED12L	116931	broad.mit.edu	37	3	150845620	150845620	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:150845620C>T	ENST00000474524.1	+	4	443	c.405C>T	c.(403-405)atC>atT	p.I135I	MED12L_ENST00000422248.2_Silent_p.I135I|MED12L_ENST00000273432.4_Silent_p.I135I|MED12L_ENST00000309237.4_Silent_p.I135I	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	135					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGGTTCCTATCCTTAGTAAAA	0.338000													18	34					0	0	9.7654e-05	0	0
DSG1	1828	broad.mit.edu	37	18	28906962	28906962	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr18:28906962C>T	ENST00000257192.4	+	3	422	c.210C>T	c.(208-210)atC>atT	p.I70I		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	70	Cadherin 1.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GGAACCCAATCGCCAAAGTAG	0.413000													9	76					0	0	3.86212e-05	0	0
ANK3	288	broad.mit.edu	37	10	61833835	61833835	+	Silent	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:61833835T>C	ENST00000280772.1	-	37	6995	c.6804A>G	c.(6802-6804)gaA>gaG	p.E2268E	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2268					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ACATGGTTTCTTCAATTCTTT	0.478000													15	53					0	0	7.07596e-05	0	0
PRPF8	10594	broad.mit.edu	37	17	1579541	1579541	+	Silent	SNP	A	A	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:1579541A>G	ENST00000572621.1	-	16	2777	c.2512T>C	c.(2512-2514)Ttg>Ctg	p.L838L	PRPF8_ENST00000304992.6_Silent_p.L838L			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	838						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		AAGATGAGCAACTTGGTGTCA	0.522000													23	63					0	0	0.000375601	0	0
C11orf85	283129	broad.mit.edu	37	11	64726865	64726865	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:64726865G>A	ENST00000530444.1	-	3	223	c.13C>T	c.(13-15)Ccc>Tcc	p.P5S	C11orf85_ENST00000536065.1_5'UTR|C11orf85_ENST00000301896.5_Missense_Mutation_p.P5S|C11orf85_ENST00000432175.1_Missense_Mutation_p.P5S			Q3KP22	CK085_HUMAN	chromosome 11 open reading frame 85	5										breast(2)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(2)	7						TAGGTAAAGGGTTTTAAACTC	0.373000													25	72					0	0	0.000184323	0	0
FAM91A1	157769	broad.mit.edu	37	8	124818335	124818335	+	Missense_Mutation	SNP	A	A	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:124818335A>T	ENST00000334705.7	+	20	2144	c.1898A>T	c.(1897-1899)aAt>aTt	p.N633I	FAM91A1_ENST00000521166.1_Missense_Mutation_p.N633I	NM_144963.2	NP_659400.2	Q658Y4	F91A1_HUMAN	family with sequence similarity 91, member A1	633										breast(4)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			ACTCGTGTCAATATGGGTGTT	0.388000													12	82					0	0	0.000151284	0	0
FSTL1	11167	broad.mit.edu	37	3	120169561	120169561	+	Silent	SNP	C	C	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:120169561C>G	ENST00000295633.3	-	2	389	c.33G>C	c.(31-33)gcG>gcC	p.A11A	FSTL1_ENST00000485968.1_5'UTR|FSTL1_ENST00000424703.2_Silent_p.A11A	NM_007085.4	NP_009016.1	Q12841	FSTL1_HUMAN	follistatin-like 1	11					BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|skin(1)	20				GBM - Glioblastoma multiforme(114;0.189)		CCGCCACCAGCGCGAGCGCGA	0.721000													5	5					0	0	1.23904e-05	0	0
SLIT3	6586	broad.mit.edu	37	5	168212958	168212958	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:168212958C>T	ENST00000519560.1	-	12	1524	c.1105G>A	c.(1105-1107)Gag>Aag	p.E369K	SLIT3_ENST00000404867.3_Missense_Mutation_p.E369K|SLIT3_ENST00000332966.8_Missense_Mutation_p.E369K	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	369					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGACAATCTCGGTGATCTTG	0.522000													8	36					0	0	0.000274275	0	0
PTCH2	8643	broad.mit.edu	37	1	45292598	45292598	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:45292598C>T	ENST00000447098.2	-	17	2682	c.2671G>A	c.(2671-2673)Gac>Aac	p.D891N	PTCH2_ENST00000372192.3_Missense_Mutation_p.D891N	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	891					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					CCCGTGGTGTCGTATTTGTCG	0.642000									Basal Cell Nevus syndrome				40	116					0	0	0.000147903	0	0
SGMS1	259230	broad.mit.edu	37	10	52103437	52103437	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:52103437G>A	ENST00000361781.2	-	7	1397	c.438C>T	c.(436-438)ttC>ttT	p.F146F	SGMS1_ENST00000429490.1_Intron|SGMS1_ENST00000361543.2_Silent_p.F146F	NM_147156.3	NP_671512.1	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	152					apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						TGGTGAGAACGAAACAGGAAA	0.502000													7	25					0	0	0.000157383	0	0
AMOTL2	51421	broad.mit.edu	37	3	134086519	134086519	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:134086519G>A	ENST00000514516.1	-	3	1213	c.1035C>T	c.(1033-1035)tcC>tcT	p.S345S	AMOTL2_ENST00000249883.5_Silent_p.S287S|AMOTL2_ENST00000422605.2_Silent_p.S287S|AMOTL2_ENST00000513145.1_Silent_p.S287S	NM_001278683.1	NP_001265612.1	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	287										endometrium(8)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	19						GTGGACTGAGGGAGCTCAGGG	0.662000													9	15					0	0	0.000274275	0	0
NSUN2	54888	broad.mit.edu	37	5	6600246	6600246	+	Silent	SNP	G	G	A	rs1057838		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:6600246G>A	ENST00000264670.6	-	19	2408	c.2097C>T	c.(2095-2097)ctC>ctT	p.L699L	NSUN2_ENST00000506139.1_Silent_p.L664L|NSUN2_ENST00000539938.1_Silent_p.L463L	NM_017755.5	NP_060225.4	Q08J23	NSUN2_HUMAN	NOP2/Sun RNA methyltransferase family, member 2	699						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	41						CCATCATCCTGAGATAATGAA	0.522000													25	29					0	0	0.00047179	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140750030	140750030	+	Silent	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:140750030T>C	ENST00000576222.1	+	1	200	c.69T>C	c.(67-69)tcT>tcC	p.S23S	PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTGCTCTCTTTGTTAGACC	0.582000													10	31					0	0	0.000442599	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269501	150269501	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:150269501C>T	ENST00000255945.2	+	3	518	c.343C>T	c.(343-345)Cat>Tat	p.H115Y	GIMAP4_ENST00000494750.1_3'UTR|GIMAP4_ENST00000461940.1_Missense_Mutation_p.H129Y	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	115							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCAGGGCCTCATGCTCTGCT	0.507000													9	46					0	0	0.000274275	0	0
C9orf131	138724	broad.mit.edu	37	9	35045092	35045092	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:35045092C>T	ENST00000312292.5	+	2	2513	c.2466C>T	c.(2464-2466)ttC>ttT	p.F822F	C9orf131_ENST00000354479.5_Silent_p.F749F|C9orf131_ENST00000421362.2_Silent_p.F774F	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	822										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			TTCCAGACTTCTGGGGACTCC	0.552000													25	227					0	0	0.000279167	0	0
FAT2	2196	broad.mit.edu	37	5	150925776	150925776	+	Missense_Mutation	SNP	G	G	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:150925776G>C	ENST00000261800.5	-	9	4924	c.4912C>G	c.(4912-4914)Cca>Gca	p.P1638A		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1638	Cadherin 14.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGCCATTGTGGGGAGCCTTGA	0.468000													4	62					0	0	1.23904e-05	0	0
MKRN3	7681	broad.mit.edu	37	15	23811356	23811356	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:23811356C>T	ENST00000314520.3	+	1	903	c.427C>T	c.(427-429)Cct>Tct	p.P143S	MKRN3_ENST00000568252.1_Intron|MKRN3_ENST00000564592.1_Intron	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	143						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		AGGTGGAGGCCCTAGCACGGC	0.652000													12	29					0	0	0.000151284	0	0
PDE6A	5145	broad.mit.edu	37	5	149310691	149310691	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:149310691G>A	ENST00000255266.5	-	4	877	c.758C>T	c.(757-759)aCg>aTg	p.T253M		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	253					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TTCGATGTCCGTAAGTTCTTC	0.443000													14	52					0	0	0.000422831	0	0
PTPRR	5801	broad.mit.edu	37	12	71094942	71094942	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:71094942G>A	ENST00000283228.2	-	7	1621	c.1169C>T	c.(1168-1170)tCa>tTa	p.S390L	PTPRR_ENST00000549308.1_Missense_Mutation_p.S145L|PTPRR_ENST00000378778.1_Missense_Mutation_p.S184L|PTPRR_ENST00000342084.4_Missense_Mutation_p.S278L|PTPRR_ENST00000440835.2_Missense_Mutation_p.S145L	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	390					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GAGTAAATGTGAACTTGCCAC	0.458000													9	17					0	0	0.000151284	0	0
ITGA5	3678	broad.mit.edu	37	12	54798495	54798495	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:54798495C>T	ENST00000293379.4	-	13	1670	c.1409G>A	c.(1408-1410)gGa>gAa	p.G470E	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	470					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						ACCAGGATATCCATTGCCATC	0.562000											OREG0021554	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	52					0	0	0.000106405	0	0
NPFFR2	10886	broad.mit.edu	37	4	73013163	73013163	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:73013163C>T	ENST00000308744.6	+	4	1301	c.1203C>T	c.(1201-1203)taC>taT	p.Y401Y	NPFFR2_ENST00000344413.5_3'UTR|NPFFR2_ENST00000358749.3_Silent_p.Y299Y|NPFFR2_ENST00000506359.1_3'UTR|NPFFR2_ENST00000395999.1_Silent_p.Y302Y	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	401					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TCTCAGACTACGCTGACCTTT	0.468000													27	30					0	0	9.22233e-05	0	0
ZNF335	63925	broad.mit.edu	37	20	44592255	44592255	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:44592255G>T	ENST00000322927.2	-	9	1490	c.1390C>A	c.(1390-1392)Ccc>Acc	p.P464T	ZNF335_ENST00000426788.1_Missense_Mutation_p.P309T	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				CACAGGAAGGGCCTCAAAAGT	0.572000													49	65					1.18269e-54	2.5075e-53	0.000147903	1	0
SPRY3	10251	broad.mit.edu	37	X	155003856	155003856	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:155003856C>T	ENST00000302805.2	+	2	754	c.323C>T	c.(322-324)tCa>tTa	p.S108L		NM_005840.1	NP_005831.1	O43610	SPY3_HUMAN	sprouty homolog 3 (Drosophila)	108					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane						all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCCTCACCTTCAGGCCAATCC	0.552000													19	43					0	0	0.000175454	0	0
INMT	11185	broad.mit.edu	37	7	30795310	30795310	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:30795310C>T	ENST00000013222.5	+	3	651	c.635C>T	c.(634-636)tCc>tTc	p.S212F	INMT_ENST00000484180.1_3'UTR|INMT-FAM188B_ENST00000458257.1_Intron|INMT_ENST00000409539.1_Missense_Mutation_p.S211F	NM_001199219.1|NM_006774.4	NP_001186148.1|NP_006765.4	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	212						cytoplasm	amine N-methyltransferase activity			kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|stomach(1)	23						CGTGAATTTTCCTGCGTGGCC	0.597000													24	25					0	0	0.000295444	0	0
PLA2G2F	64600	broad.mit.edu	37	1	20474889	20474889	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:20474889C>T	ENST00000375102.3	+	5	733	c.631C>T	c.(631-633)Ccc>Tcc	p.P211S		NM_022819.3	NP_073730.3	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	168					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		CCCCGCCCCTCCCTAGAGCCT	0.657000													7	25					0	0	0.000442599	0	0
E2F1	1869	broad.mit.edu	37	20	32268156	32268156	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:32268156C>T	ENST00000343380.5	-	2	467	c.328G>A	c.(328-330)Ggc>Agc	p.G110S		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	110				KRRLDLETDHQYLAESSGPARGR -> RTPGTPRRQRRLCP PRRPGRAPC (in Ref. 8; AAD14150).	apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						CGGCCTCTGCCCCGAGCTGGC	0.602000													11	29					0	0	0.00010058	0	0
ZBTB21	49854	broad.mit.edu	37	21	43411272	43411272	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr21:43411272G>A	ENST00000310826.5	-	3	3116	c.2933C>T	c.(2932-2934)cCc>cTc	p.P978L	ZBTB21_ENST00000398511.3_Missense_Mutation_p.P978L|ZBTB21_ENST00000398499.1_Missense_Mutation_p.P978L|ZBTB21_ENST00000398505.3_Missense_Mutation_p.P777L	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		AGAGTTTGTGGGAACAGGGCA	0.562000													44	76					0	0	0.000147903	0	0
SLC6A11	6538	broad.mit.edu	37	3	10975831	10975831	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:10975831C>T	ENST00000254488.2	+	12	1620	c.1554C>T	c.(1552-1554)atC>atT	p.I518I		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	518					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		GCTGGATGATCATGACCCCTG	0.562000													22	80					0	0	0.000375601	0	0
NAV2	89797	broad.mit.edu	37	11	20104716	20104716	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:20104716C>T	ENST00000396085.1	+	27	5859	c.5498C>T	c.(5497-5499)tCc>tTc	p.S1833F	NAV2_ENST00000349880.4_Missense_Mutation_p.S1830F|NAV2_ENST00000527559.2_Missense_Mutation_p.S1818F|NAV2_ENST00000396087.3_Missense_Mutation_p.S1889F|NAV2_ENST00000533917.1_Missense_Mutation_p.S894F|NAV2_ENST00000540292.1_Missense_Mutation_p.S1820F|NAV2_ENST00000311043.8_Missense_Mutation_p.S894F|NAV2_ENST00000360655.4_Missense_Mutation_p.S1766F	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1889						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						AATTCTCACTCCAACTCTCTG	0.483000													11	102					0	0	6.40141e-05	0	0
ZNF77	58492	broad.mit.edu	37	19	2933614	2933614	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:2933614G>A	ENST00000314531.4	-	4	1603	c.1511C>T	c.(1510-1512)tCc>tTc	p.S504F		NM_021217.2	NP_067040.1	Q15935	ZNF77_HUMAN	zinc finger protein 77	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGGGACGAGGAACAACTGTA	0.498000													22	57					0	0	0.00047179	0	0
CXorf36	79742	broad.mit.edu	37	X	45013293	45013293	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:45013293G>A	ENST00000398000.2	-	4	897	c.823C>T	c.(823-825)Ctg>Ttg	p.L275L	CXorf36_ENST00000477281.1_5'UTR	NM_176819.3	NP_789789.2	Q9H7Y0	CX036_HUMAN	chromosome X open reading frame 36	275						extracellular region				endometrium(1)|large_intestine(2)|lung(4)	7						AAAGACTCCAGGACACCCAGG	0.532000													26	23					0	0	0.000409698	0	0
STRC	161497	broad.mit.edu	37	15	43893105	43893105	+	Silent	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:43893105T>G	ENST00000450892.2	-	25	4886	c.4809A>C	c.(4807-4809)ccA>ccC	p.P1603P	STRC_ENST00000541030.1_Silent_p.P830P	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1603					sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GGAGCTCCTCTGGCCGCAGTC	0.557000													29	20					0	0	0.000191422	0	0
TNFRSF10A	8797	broad.mit.edu	37	8	23059404	23059404	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:23059404C>T	ENST00000221132.3	-	4	610	c.546G>A	c.(544-546)acG>acA	p.T182T		NM_003844.3	NP_003835.3	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily, member 10a	182					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			NS(2)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|skin(1)	16		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		TGTTCCTGGTCGTGGTGCAGG	0.512000													15	41					0	0	0.000132079	0	0
SCN11A	11280	broad.mit.edu	37	3	38988284	38988284	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:38988284G>A	ENST00000302328.3	-	2	580	c.382C>T	c.(382-384)Cat>Tat	p.H128Y	SCN11A_ENST00000444237.2_Missense_Mutation_p.H128Y|SCN11A_ENST00000450244.1_Missense_Mutation_p.H128Y|SCN11A_ENST00000456224.3_Missense_Mutation_p.H128Y	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	128					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.H128N(1)		NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GGATATGAATGGACTGAGACT	0.408000													25	134					0	0	0.000147802	0	0
XIRP2	129446	broad.mit.edu	37	2	168099458	168099458	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:168099458G>A	ENST00000409195.1	+	9	1645	c.1556G>A	c.(1555-1557)aGt>aAt	p.S519N	XIRP2_ENST00000295237.9_Missense_Mutation_p.S519N|XIRP2_ENST00000409273.1_Missense_Mutation_p.S297N|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	344					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GATTATATCAGTGAAGTTTCT	0.328000													4	18					0	0	1.23904e-05	0	0
MUC16	94025	broad.mit.edu	37	19	9046965	9046965	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:9046965C>T	ENST00000397910.4	-	5	34869	c.34666G>A	c.(34666-34668)Gac>Aac	p.D11556N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11558	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTACTGGTGTCTGTCCCAGAA	0.517000													5	18					0	0	3.59834e-05	0	0
KCNH5	27133	broad.mit.edu	37	14	63473173	63473173	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:63473173A>G	ENST00000322893.7	-	3	483	c.215T>C	c.(214-216)tTg>tCg	p.L72S	KCNH5_ENST00000394968.1_Missense_Mutation_p.L14S|KCNH5_ENST00000394964.2_Missense_Mutation_p.L14S|KCNH5_ENST00000420622.2_Missense_Mutation_p.L72S	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	72	PAS.				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CTTGTCAGTCAATTCCCCATA	0.353000													6	51					0	0	8.12818e-05	0	0
IGHV2-70	28454	broad.mit.edu	37	14	107178854	107178854	+	RNA	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:107178854G>A	ENST00000390634.2	-	0	398																											TGTGTCCACAGGGTCCATGTT	0.507000													9	76					0	0	3.86212e-05	0	0
ARFIP2	23647	broad.mit.edu	37	11	6499989	6499989	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:6499989G>A	ENST00000254584.2	-	5	599	c.516C>T	c.(514-516)agC>agT	p.S172S	ARFIP2_ENST00000525235.1_Silent_p.S172S|ARFIP2_ENST00000423813.2_Silent_p.S134S|ARFIP2_ENST00000396777.3_Silent_p.S172S|ARFIP2_ENST00000445086.2_Silent_p.S87S	NM_012402.3	NP_036534.1	P53365	ARFP2_HUMAN	ADP-ribosylation factor interacting protein 2	172	AH.				actin cytoskeleton organization|cellular component movement|lamellipodium assembly|ruffle organization|small GTPase mediated signal transduction	cell cortex|plasma membrane|ruffle	GTP binding|GTP-dependent protein binding|Rac GTPase binding			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|pancreas(1)|prostate(1)|skin(2)	15		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;3.41e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGGACTTCTGGCTGAGGTCAG	0.622000													4	19					0	0	1.23904e-05	0	0
TEX12	56158	broad.mit.edu	37	11	112042594	112042594	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:112042594C>T	ENST00000280358.4	+	5	459	c.327C>T	c.(325-327)ttC>ttT	p.F109F	RP11-356J5.4_ENST00000527589.1_RNA|TEX12_ENST00000530752.1_Silent_p.F109F|SDHD_ENST00000532612.1_Intron|SDHD_ENST00000532699.1_Intron	NM_031275.4	NP_112565.1	Q9BXU0	TEX12_HUMAN	testis expressed 12	109										endometrium(1)|large_intestine(2)|lung(1)	4		all_cancers(61;5.7e-14)|all_epithelial(67;3.4e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.2e-06)|BRCA - Breast invasive adenocarcinoma(274;1.4e-06)|all cancers(92;1.97e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0512)		AAAGAGAGTTCCTGCGACAGA	0.323000													87	82					0	0	0.000147903	0	0
FREM1	158326	broad.mit.edu	37	9	14823208	14823208	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:14823208C>T	ENST00000380881.4	-	14	3105	c.2290G>A	c.(2290-2292)Ggg>Agg	p.G764R	FREM1_ENST00000422223.2_Missense_Mutation_p.G763R|FREM1_ENST00000380880.3_Missense_Mutation_p.G763R			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	763					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AAGCAGATCCCATGCAAAGTA	0.443000													29	42					0	0	0.000339439	0	0
PLCB4	5332	broad.mit.edu	37	20	9424845	9424845	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:9424845G>A	ENST00000378501.2	+	28	2814	c.2799G>A	c.(2797-2799)aaG>aaA	p.K933K	PLCB4_ENST00000414679.2_Silent_p.K945K|PLCB4_ENST00000334005.3_Silent_p.K933K|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000378493.1_Silent_p.K933K|PLCB4_ENST00000378473.3_Silent_p.K945K|PLCB4_ENST00000278655.4_Silent_p.K933K	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	933					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity	p.K933N(1)		NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AGCATTTAAAGAAACAGCAGA	0.318000													7	74					0	0	0.000274275	0	0
DLG4	1742	broad.mit.edu	37	17	7107071	7107071	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:7107071G>A	ENST00000399510.2	-	7	1256	c.404C>T	c.(403-405)cCa>cTa	p.P135L	DLG4_ENST00000399506.2_Missense_Mutation_p.P92L|DLG4_ENST00000485100.1_Missense_Mutation_p.P89L|DLG4_ENST00000302955.6_Missense_Mutation_p.P89L	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	92	PDZ 1.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						GAAAATGGATGGGTCGTCACC	0.607000													11	26					0	0	0.000219431	0	0
SULT1C3	442038	broad.mit.edu	37	2	108869811	108869811	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:108869811C>T	ENST00000376700.1	+	3	312	c.312C>T	c.(310-312)ttC>ttT	p.F104F	SULT1C3_ENST00000329106.2_Silent_p.F104F			Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	104						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						ATTTGGAGTTCGTTCTTGAAA	0.358000													4	14					0	0	1.23904e-05	0	0
CBLN3	643866	broad.mit.edu	37	14	24898030	24898030	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:24898030G>A	ENST00000267406.6	-	1	701	c.231C>T	c.(229-231)gtC>gtT	p.V77V	CBLN3_ENST00000555436.1_Intron	NM_001039771.2	NP_001034860.1	Q6UW01	CBLN3_HUMAN	cerebellin 3 precursor	77	C1q.|Necessary for interaction with CBLN3, and homotrimerization (By similarity).					cell junction|extracellular region|synapse				central_nervous_system(1)|lung(3)	4				GBM - Glioblastoma multiforme(265;0.00159)		GGTGGCTTCGGACCGCAGCAA	0.677000													4	15					0	0	0.00024832	0	0
DLG4	1742	broad.mit.edu	37	17	7107072	7107072	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:7107072G>A	ENST00000399510.2	-	7	1255	c.403C>T	c.(403-405)Cca>Tca	p.P135S	DLG4_ENST00000399506.2_Missense_Mutation_p.P92S|DLG4_ENST00000485100.1_Missense_Mutation_p.P89S|DLG4_ENST00000302955.6_Missense_Mutation_p.P89S	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	92	PDZ 1.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						AAAATGGATGGGTCGTCACCG	0.607000													11	25					0	0	0.000219431	0	0
MAEL	84944	broad.mit.edu	37	1	166959028	166959028	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:166959028G>A	ENST00000367872.4	+	2	431	c.187G>A	c.(187-189)Gcc>Acc	p.A63T	MAEL_ENST00000367870.2_Intron	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	63					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						AGAATGGAGGGCCGCTCAGGG	0.517000													10	26					0	0	0.00010058	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75407338	75407338	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:75407338C>T	ENST00000394810.2	-	4	2221	c.2072G>A	c.(2071-2073)gGg>gAg	p.G691E	SYNPO2L_ENST00000372872.4_Intron|SYNPO2L_ENST00000372873.4_Missense_Mutation_p.G467E	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	691	Pro-rich.					cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					ACTCCTGGCCCCTACTGGCTG	0.602000													20	48					0	0	0.000132079	0	0
SLC4A2	6522	broad.mit.edu	37	7	150764051	150764051	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:150764051C>T	ENST00000485713.1	+	7	1977	c.937C>T	c.(937-939)Cga>Tga	p.R313*	SLC4A2_ENST00000392826.2_Nonsense_Mutation_p.R304*|SLC4A2_ENST00000461735.1_Nonsense_Mutation_p.R299*|SLC4A2_ENST00000413384.2_Nonsense_Mutation_p.R313*|SLC4A2_ENST00000310317.5_Nonsense_Mutation_p.R231*	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	313	Pro-rich.				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACCTCGGGCCCGACCCCGGGC	0.652000													38	35					0	0	0.000147903	0	0
SCNN1B	6338	broad.mit.edu	37	16	23379253	23379253	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:23379253C>T	ENST00000343070.2	+	5	1029	c.853C>T	c.(853-855)Cct>Tct	p.P285S	SCNN1B_ENST00000307331.5_Missense_Mutation_p.P330S|SCNN1B_ENST00000568085.1_Missense_Mutation_p.P285S|SCNN1B_ENST00000568923.1_Missense_Mutation_p.P258S	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	285					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	GAAGGCACTTCCTTCGGCCAA	0.498000													44	71					0	0	0.000147903	0	0
DACH1	1602	broad.mit.edu	37	13	72131253	72131253	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr13:72131253C>T	ENST00000305425.4	-	6	1901	c.1479G>A	c.(1477-1479)ctG>ctA	p.L493L	DACH1_ENST00000359684.2_Silent_p.L545L|DACH1_ENST00000313174.7_Intron|DACH1_ENST00000354591.4_Intron	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	543					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		ATAAGCCCATCAGCATCTGGT	0.428000													7	25					0	0	0.000157383	0	0
MPPED2	744	broad.mit.edu	37	11	30557687	30557687	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:30557687G>A	ENST00000448418.2	-	3	524	c.164C>T	c.(163-165)gCg>gTg	p.A55V	MPPED2_ENST00000358117.5_Missense_Mutation_p.A55V	NM_001145399.1	NP_001138871.1	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	55					nervous system development		hydrolase activity|metal ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(15)|skin(2)|upper_aerodigestive_tract(2)	33						CGTGTGGCCCGCTGGTTTTGG	0.483000													9	27					0	0	3.86212e-05	0	0
NLRP12	91662	broad.mit.edu	37	19	54314534	54314534	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:54314534C>T	ENST00000324134.6	-	3	547	c.379G>A	c.(379-381)Gaa>Aaa	p.E127K	NLRP12_ENST00000354278.3_Missense_Mutation_p.E127K|NLRP12_ENST00000351894.4_Missense_Mutation_p.E127K|NLRP12_ENST00000391775.3_Missense_Mutation_p.E127K|NLRP12_ENST00000345770.5_Missense_Mutation_p.E127K|NLRP12_ENST00000535162.1_Missense_Mutation_p.E127K|NLRP12_ENST00000391773.1_Missense_Mutation_p.E127K|NLRP12_ENST00000391772.1_Missense_Mutation_p.E127K	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	127					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding	p.E127K(1)		NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CTGTAGGTTTCCTGGGGATCT	0.542000													13	77					0	0	0.000308642	0	0
DIDO1	11083	broad.mit.edu	37	20	61512857	61512857	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:61512857T>G	ENST00000266070.4	-	16	4776	c.4451A>C	c.(4450-4452)aAa>aCa	p.K1484T	DIDO1_ENST00000395343.1_Missense_Mutation_p.K1484T	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1484					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CTCGATCTGTTTGTTCAGCTC	0.627000													24	117					0	0	0.000375601	0	0
BNC2	54796	broad.mit.edu	37	9	16419500	16419500	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:16419500G>A	ENST00000380672.4	-	7	2844	c.2787C>T	c.(2785-2787)ctC>ctT	p.L929L	BNC2_ENST00000545497.1_Silent_p.L834L|BNC2_ENST00000380667.2_Silent_p.L862L	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	929					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		CCCTGACATCGAGCCCCATGG	0.577000													21	77					0	0	0.000229342	0	0
NLRP8	126205	broad.mit.edu	37	19	56459380	56459380	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:56459380G>A	ENST00000291971.3	+	1	183	c.112G>A	c.(112-114)Gaa>Aaa	p.E38K	NLRP8_ENST00000590542.1_Missense_Mutation_p.E38K	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	38	DAPIN.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CTCCCCATGTGAAAATGGGGT	0.527000													23	38					0	0	0.000229342	0	0
ATF6B	1388	broad.mit.edu	37	6	32083517	32083517	+	Nonstop_Mutation	SNP	C	C	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:32083517C>A	ENST00000375201.4	-	18	2147	c.2102G>T	c.(2101-2103)tGa>tTa	p.*701L	ATF6B_ENST00000375203.3_Nonstop_Mutation_p.*704L			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	0					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						TGGCAGAGGTCAGGGATGATT	0.617000													46	224					9.82405e-12	2.0656e-10	0.000147903	1	0
LURAP1L	286343	broad.mit.edu	37	9	12821469	12821469	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:12821469G>A	ENST00000319264.3	+	2	1092	c.397G>A	c.(397-399)Gaa>Aaa	p.E133K		NM_203403.1	NP_981948.1	Q8IV03	CI150_HUMAN	leucine rich adaptor protein 1-like	136																	GTGGATGATCGAAGAAAAAGC	0.517000													39	42					0	0	0.000191422	0	0
GALNTL6	442117	broad.mit.edu	37	4	173873285	173873285	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:173873285C>T	ENST00000506823.1	+	10	1904	c.1247C>T	c.(1246-1248)tCt>tTt	p.S416F	GALNTL6_ENST00000508122.1_Missense_Mutation_p.S399F	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	416						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						GGGGACATCTCTGCCCAGAAG	0.567000													5	31					0	0	3.59834e-05	0	0
IKBKB	3551	broad.mit.edu	37	8	42178259	42178259	+	Missense_Mutation	SNP	G	G	A	rs147186110		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:42178259G>A	ENST00000520810.1	+	16	1771	c.1585G>A	c.(1585-1587)Gaa>Aaa	p.E529K	IKBKB_ENST00000416505.2_Missense_Mutation_p.E470K|IKBKB_ENST00000522147.1_Intron|IKBKB_ENST00000379708.3_Missense_Mutation_p.E306K|IKBKB_ENST00000520835.1_Missense_Mutation_p.E527K	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	529					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	TTAGGAGAACGAAGTGAAACT	0.567000													48	69					0	0	0.000147903	0	0
CPT1C	126129	broad.mit.edu	37	19	50208012	50208012	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:50208012C>T	ENST00000392518.4	+	8	1111	c.739C>T	c.(739-741)Ccg>Tcg	p.P247S	CPT1C_ENST00000598293.1_Missense_Mutation_p.P247S|CPT1C_ENST00000354199.5_Missense_Mutation_p.P247S|CPT1C_ENST00000405931.2_Missense_Mutation_p.P247S|CPT1C_ENST00000323446.5_Missense_Mutation_p.P247S	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	247					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		CTCCCGAAATCCGCTGATGGT	0.607000													9	33					0	0	6.40141e-05	0	0
CUZD1	50624	broad.mit.edu	37	10	124593240	124593240	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:124593240G>A	ENST00000368904.1	-	10	2548	c.1599C>T	c.(1597-1599)tcC>tcT	p.S533S	CUZD1_ENST00000545804.1_Silent_p.S533S|CUZD1_ENST00000392790.1_Silent_p.S533S			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	533					cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		GTCCTATGATGGAATCTGTTT	0.408000													46	79					0	0	0.000147903	0	0
PRDM9	56979	broad.mit.edu	37	5	23522412	23522412	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:23522412G>A	ENST00000296682.3	+	7	690		c.e7-1			NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9						meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CTCCAACCTAGAACTCAGGAA	0.428000										HNSCC(3;0.000094)			25	118					0	0	0.000117367	0	0
DNMT3B	1789	broad.mit.edu	37	20	31394046	31394046	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:31394046C>T	ENST00000328111.2	+	22	2654	c.2333C>T	c.(2332-2334)tCg>tTg	p.S778L	DNMT3B_ENST00000201963.3_Missense_Mutation_p.S770L|DNMT3B_ENST00000348286.2_Intron|DNMT3B_ENST00000456297.2_Intron|DNMT3B_ENST00000443239.3_Intron|DNMT3B_ENST00000353855.2_Missense_Mutation_p.S758L|DNMT3B_ENST00000344505.4_Intron	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	778					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						ACCACCAAGTCGAACTCGATC	0.448000													13	49					0	0	0.000219431	0	0
SI	6476	broad.mit.edu	37	3	164709985	164709985	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:164709985G>A	ENST00000264382.3	-	43	5025	c.4963C>T	c.(4963-4965)Cgg>Tgg	p.R1655W		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1655	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCAAACCACCGAGCATTGGGG	0.343000										HNSCC(35;0.089)			8	64					0	0	0.00010058	0	0
SYCP2	10388	broad.mit.edu	37	20	58441356	58441356	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:58441356C>A	ENST00000357552.3	-	41	4537	c.4312G>T	c.(4312-4314)Gaa>Taa	p.E1438*	SYCP2_ENST00000371001.2_Nonsense_Mutation_p.E1438*			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1438					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			ACCACAAATTCCTTTTCCAAA	0.264000													21	38					5.35356e-11	1.12447e-09	0.000375601	1	0
PRR23C	389152	broad.mit.edu	37	3	138763116	138763116	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:138763116C>T	ENST00000413199.1	-	1	618	c.347G>A	c.(346-348)gGc>gAc	p.G116D	MRPS22_ENST00000495075.1_Intron|PRR23C_ENST00000502927.2_Missense_Mutation_p.G116D	NM_001134657.1	NP_001128129.1	Q6ZRP0	PR23C_HUMAN	proline rich 23C	116										breast(2)|lung(7)|skin(2)	11						AGACCAGTCGCCCTGCGCTCC	0.632000													4	4					0	0	3.59834e-05	0	0
GLRA1	2741	broad.mit.edu	37	5	151235895	151235895	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:151235895C>T	ENST00000274576.4	-	5	818	c.526G>A	c.(526-528)Gat>Aat	p.D176N	GLRA1_ENST00000471351.2_5'UTR|GLRA1_ENST00000545569.1_Missense_Mutation_p.D93N|GLRA1_ENST00000455880.2_Missense_Mutation_p.D176N	NM_000171.3|NM_001146040.1	NP_000162.2|NP_001139512.1	P23415	GLRA1_HUMAN	glycine receptor, alpha 1	176					muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	23		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GTCTGGACATCCATGGGGAAA	0.488000													20	53					0	0	0.000375601	0	0
PRKAA2	5563	broad.mit.edu	37	1	57161680	57161680	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:57161680C>T	ENST00000371244.4	+	6	702	c.636C>T	c.(634-636)ctC>ctT	p.L212L		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	212	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						GTGGCACCCTCCCATTTGATG	0.423000													38	270					0	0	0.000132358	0	0
DDHD1	80821	broad.mit.edu	37	14	53539401	53539401	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:53539401G>T	ENST00000357758.3	-	6	1600	c.1417C>A	c.(1417-1419)Cct>Act	p.P473T	DDHD1_ENST00000395606.1_Missense_Mutation_p.P480T|DDHD1_ENST00000323669.5_Missense_Mutation_p.P473T	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	473					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					ACTTTGTCAGGAGTAATGGAA	0.333000													23	26					4.7796e-09	1.00081e-07	9.22233e-05	1	0
ASNS	440	broad.mit.edu	37	7	97487649	97487649	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:97487649G>A	ENST00000175506.4	-	8	1372	c.844C>T	c.(844-846)Cct>Tct	p.P282S	ASNS_ENST00000437628.1_Missense_Mutation_p.P199S|ASNS_ENST00000422745.1_Missense_Mutation_p.P261S|ASNS_ENST00000444334.1_Missense_Mutation_p.P261S|ASNS_ENST00000394309.3_Missense_Mutation_p.P282S|ASNS_ENST00000455086.1_Missense_Mutation_p.P199S|ASNS_ENST00000394308.3_Missense_Mutation_p.P282S	NM_183356.3	NP_899199.2	P08243	ASNS_HUMAN	asparagine synthetase (glutamine-hydrolyzing)	282	Asparagine synthetase.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GTCTGGAGAGGATACTGTACT	0.493000													10	40					0	0	3.86212e-05	0	0
OR1L8	138881	broad.mit.edu	37	9	125329898	125329898	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:125329898G>A	ENST00000304865.2	-	1	940	c.859C>T	c.(859-861)Cct>Tct	p.P287S		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P287T(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TAGATAAAAGGATTGAGCATG	0.458000													29	96					0	0	0.000491102	0	0
CORO7	79585	broad.mit.edu	37	16	4408059	4408059	+	Missense_Mutation	SNP	A	A	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:4408059A>T	ENST00000251166.4	-	25	2648	c.2503T>A	c.(2503-2505)Tgg>Agg	p.W835R	CORO7_ENST00000574025.1_Missense_Mutation_p.W750R|CORO7_ENST00000537233.2_Missense_Mutation_p.W817R|CORO7-PAM16_ENST00000572274.1_5'UTR|CORO7_ENST00000539968.1_Missense_Mutation_p.W615R|CORO7-PAM16_ENST00000572467.1_Missense_Mutation_p.W835R	NM_024535.4	NP_078811.3			coronin 7											breast(3)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|prostate(2)|skin(2)|urinary_tract(2)	23						ACAGGCTCCCAGATCACAGCC	0.617000													12	16					0	0	0.00010058	0	0
OR56B1	387748	broad.mit.edu	37	11	5758241	5758241	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:5758241C>T	ENST00000317121.3	+	1	561	c.495C>T	c.(493-495)gtC>gtT	p.V165V	TRIM5_ENST00000380027.1_Intron	NM_001005180.2	NP_001005180.1	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B, member 1	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		GCTTATTTGTCACTCCAGTGC	0.463000													6	35					0	0	0.000157383	0	0
TONSL	4796	broad.mit.edu	37	8	145659433	145659433	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:145659433G>A	ENST00000409379.3	-	21	3344	c.3315C>T	c.(3313-3315)ctC>ctT	p.L1105L		NM_013432.4	NP_038460.4	Q96HA7	TONSL_HUMAN	tonsoku-like, DNA repair protein	1105					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity			biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|lung(14)|ovary(3)|prostate(1)|skin(1)	26						GATTGGAGGAGAGGTCAAGGA	0.677000													15	28					0	0	5.01169e-05	0	0
MKRN3	7681	broad.mit.edu	37	15	23812282	23812282	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:23812282G>A	ENST00000314520.3	+	1	1829	c.1353G>A	c.(1351-1353)atG>atA	p.M451I	MKRN3_ENST00000568252.1_Intron|MKRN3_ENST00000564592.1_Intron|MKRN3_ENST00000568945.1_Intron	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	451						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		CTGTGCGAATGGGAGAGGGCA	0.522000													6	62					0	0	3.59834e-05	0	0
APOB	338	broad.mit.edu	37	2	21235361	21235361	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:21235361G>A	ENST00000233242.1	-	26	4506	c.4379C>T	c.(4378-4380)tCc>tTc	p.S1460F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1460					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGTCCCCAGGAACTAGATGC	0.388000													100	231					0	0	0.000147903	0	0
BPIFB6	128859	broad.mit.edu	37	20	31620830	31620830	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:31620830G>A	ENST00000349552.1	+	2	138	c.138G>A	c.(136-138)aaG>aaA	p.K46K		NM_174897.2	NP_777557.1	Q8NFQ5	BPIL3_HUMAN	BPI fold containing family B, member 6	46						extracellular region	lipid binding										TCCTGGAGAAGATGGCAGCCG	0.557000													15	57					0	0	0.000422831	0	0
CDH17	1015	broad.mit.edu	37	8	95201472	95201472	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:95201472C>T	ENST00000027335.3	-	3	217	c.93G>A	c.(91-93)ctG>ctA	p.L31L	CDH17_ENST00000450165.2_Silent_p.L31L|CDH17_ENST00000441892.2_Silent_p.L31L	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	31	Cadherin 1.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TCATGGGTTTCAGGGGTCCAC	0.393000													26	102					0	0	8.91981e-05	0	0
TM6SF1	53346	broad.mit.edu	37	15	83781551	83781551	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:83781551C>T	ENST00000322019.9	+	2	369	c.95C>T	c.(94-96)tCc>tTc	p.S32F	TM6SF1_ENST00000379390.6_Missense_Mutation_p.S32F|TM6SF1_ENST00000379386.4_Missense_Mutation_p.S32F|TM6SF1_ENST00000564988.1_3'UTR|TM6SF1_ENST00000565774.1_Missense_Mutation_p.S32F			Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1	32						integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						CGTTGCAGTTCCTGGACTATT	0.502000													21	67					0	0	0.000229342	0	0
MUC17	140453	broad.mit.edu	37	7	100681346	100681346	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:100681346G>A	ENST00000306151.4	+	3	6713	c.6649G>A	c.(6649-6651)Gaa>Aaa	p.E2217K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2217	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTCCTAGTGAAGGAAGCAC	0.507000													49	225					0	0	0.000147903	0	0
ZNF195	7748	broad.mit.edu	37	11	3381470	3381470	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:3381470G>A	ENST00000354599.6	-	4	656	c.552C>T	c.(550-552)ctC>ctT	p.L184L	ZNF195_ENST00000343338.7_Silent_p.L188L|ZNF195_ENST00000438262.2_3'UTR|ZNF195_ENST00000429541.2_Silent_p.L188L|ZNF195_ENST00000399602.4_Silent_p.L256L|ZNF195_ENST00000005082.9_Silent_p.L233L|ZNF195_ENST00000528796.1_Intron|ZNF195_ENST00000526601.1_Silent_p.L237L	NM_001242843.1|NM_001256825.1|NM_007152.4	NP_001229772.1|NP_001243754.1|NP_009083.2	O14628	ZN195_HUMAN	zinc finger protein 195	256	Spacer.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)	17		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		TTAGGAATGAGAGCATTTGAA	0.328000													6	43					0	0	0.000274275	0	0
FRAS1	80144	broad.mit.edu	37	4	79385217	79385217	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:79385217G>A	ENST00000264895.6	+	48	7246	c.6806G>A	c.(6805-6807)cGa>cAa	p.R2269Q		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2268					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CTGACTTCACGAAATGTTCAG	0.413000													12	42					0	0	0.000308642	0	0
CERS3	204219	broad.mit.edu	37	15	100942940	100942940	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:100942940G>A	ENST00000284382.4	-	13	1553	c.1130C>T	c.(1129-1131)cCc>cTc	p.P377L	RP11-168G16.2_ENST00000560643.1_RNA|CERS3_ENST00000538112.2_Missense_Mutation_p.P377L|RP11-168G16.2_ENST00000560718.1_RNA|CERS3_ENST00000560944.1_5'UTR|CERS3_ENST00000394113.1_Missense_Mutation_p.P377L	NM_178842.3	NP_849164.2	Q8IU89	CERS3_HUMAN	ceramide synthase 3	377						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CTGGCCATTGGGAATGAGGTG	0.537000													13	38					0	0	0.000219431	0	0
CCDC68	80323	broad.mit.edu	37	18	52609926	52609926	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr18:52609926C>T	ENST00000591504.1	-	3	371	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	CCDC68_ENST00000432185.1_Missense_Mutation_p.E33K|CCDC68_ENST00000337363.4_Missense_Mutation_p.E33K	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	33										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		TACTCGGTTTCTTCAATAATG	0.388000													5	29					0	0	1.23904e-05	0	0
KNG1	3827	broad.mit.edu	37	3	186445073	186445073	+	Silent	SNP	G	G	A	rs142183659		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:186445073G>A	ENST00000265023.4	+	5	824	c.612G>A	c.(610-612)acG>acA	p.T204T	KNG1_ENST00000447445.1_Intron|RP11-573D15.8_ENST00000599314.1_RNA|KNG1_ENST00000287611.2_Silent_p.T204T	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	204	Cystatin 2.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	TTGTGCAAACGAATTGTTCCA	0.348000													21	118					0	0	0.000295444	0	0
OPLAH	26873	broad.mit.edu	37	8	145114770	145114770	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:145114770C>T	ENST00000426825.1	-	2	247	c.166G>A	c.(166-168)Gag>Aag	p.E56K	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	56							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CCCACCTGCTCCAGGATGCGG	0.697000													5	47					0	0	8.12818e-05	0	0
PPP1R14C	81706	broad.mit.edu	37	6	150569890	150569890	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:150569890C>T	ENST00000361131.4	+	4	549	c.432C>T	c.(430-432)atC>atT	p.I144I		NM_030949.2	NP_112211.1	Q8TAE6	PP14C_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 14C	144					regulation of phosphorylation	cytoplasm|membrane				endometrium(1)|large_intestine(1)|prostate(1)	3		Ovarian(120;0.0284)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;9.14e-12)		AGGAATTTATCAAAGAGCTGC	0.388000													9	33					0	0	0.000274275	0	0
TRPV6	55503	broad.mit.edu	37	7	142569526	142569526	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:142569526C>T	ENST00000359396.3	-	15	2357	c.2112G>A	c.(2110-2112)agG>agA	p.R704R		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	704	Interaction with calmodulin.				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					GCAGGTCTCTCCTCAGGGTCC	0.577000													14	80					0	0	0.000219431	0	0
ALB	213	broad.mit.edu	37	4	74277830	74277830	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:74277830T>G	ENST00000295897.4	+	7	920	c.831T>G	c.(829-831)tgT>tgG	p.C277W	ALB_ENST00000415165.2_Missense_Mutation_p.C85W|ALB_ENST00000509063.1_Missense_Mutation_p.C277W|ALB_ENST00000503124.1_Missense_Mutation_p.C127W|ALB_ENST00000505649.1_3'UTR|ALB_ENST00000401494.3_Missense_Mutation_p.C162W	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	277	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	TGCTTGAATGTGCTGATGACA	0.453000													16	85					0	0	5.01169e-05	0	0
PDGFRB	5159	broad.mit.edu	37	5	149513489	149513489	+	Missense_Mutation	SNP	G	G	C	rs41287114	byFrequency	TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:149513489G>C	ENST00000261799.4	-	5	1183	c.714C>G	c.(712-714)atC>atG	p.I238M		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	238	Ig-like C2-type 3.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCTCATTCCCGATCACAATGC	0.562000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								7	52					0	0	0.000274275	0	0
TRIM48	79097	broad.mit.edu	37	11	55036750	55036750	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:55036750C>T	ENST00000417545.2	+	5	697	c.611C>T	c.(610-612)cCt>cTt	p.P204L		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	188						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						ATGCCCCAGCCTCTGAATCTA	0.507000													14	9					0	0	0.000308642	0	0
GRB7	2886	broad.mit.edu	37	17	37899512	37899512	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:37899512C>T	ENST00000309156.4	+	5	800	c.543C>T	c.(541-543)ttC>ttT	p.F181F	GRB7_ENST00000445327.2_Silent_p.F204F|GRB7_ENST00000309185.3_Silent_p.F181F|GRB7_ENST00000394209.2_Silent_p.F181F|GRB7_ENST00000394211.3_Silent_p.F181F|GRB7_ENST00000578702.1_3'UTR|GRB7_ENST00000394204.1_Silent_p.F181F	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	181	Ras-associating.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GCTTCGTCTTCCGGAAAAACT	0.607000													9	45					0	0	0.000274275	0	0
ZBTB7B	51043	broad.mit.edu	37	1	154988846	154988846	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:154988846C>T	ENST00000368426.3	+	4	1442	c.1305C>T	c.(1303-1305)tgC>tgT	p.C435C	ZBTB7B_ENST00000535420.1_Silent_p.C435C|ZBTB7B_ENST00000292176.2_Silent_p.C435C|ZBTB7B_ENST00000417934.2_Silent_p.C469C	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	435					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCCACCTGTGCCACAAGGCTT	0.647000													8	14					0	0	0.000157383	0	0
TM4SF4	7104	broad.mit.edu	37	3	149192792	149192792	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:149192792C>T	ENST00000305354.4	+	1	1032	c.128C>T	c.(127-129)tCc>tTc	p.S43F		NM_004617.3	NP_004608.1	P48230	T4S4_HUMAN	transmembrane 4 L six family member 4	43						integral to membrane				large_intestine(3)|lung(4)|ovary(1)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GACCACCTTTCCCAAGAGATC	0.473000													5	48					0	0	0.000157383	0	0
NR1D2	9975	broad.mit.edu	37	3	24003915	24003915	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:24003915T>C	ENST00000312521.4	+	5	1284	c.965T>C	c.(964-966)tTc>tCc	p.F322S	NR1D2_ENST00000492552.1_3'UTR	NM_001145425.1|NM_005126.4	NP_001138897.1|NP_005117.3	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	322					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			NS(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	22						AATGGACAGTTCAAAGGGAGG	0.393000													12	32					0	0	0.000308642	0	0
ATP2C1	27032	broad.mit.edu	37	3	130715608	130715608	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:130715608C>T	ENST00000510168.1	+	24	2761	c.2211C>T	c.(2209-2211)atC>atT	p.I737I	ATP2C1_ENST00000513801.1_Silent_p.I721I|ATP2C1_ENST00000422190.2_Silent_p.I737I|ATP2C1_ENST00000505330.1_Silent_p.I721I|ATP2C1_ENST00000359644.3_Silent_p.I737I|ATP2C1_ENST00000508532.1_Silent_p.I737I|ATP2C1_ENST00000393221.4_Silent_p.I771I|ATP2C1_ENST00000533801.2_Silent_p.I732I|ATP2C1_ENST00000507488.2_Silent_p.I721I|ATP2C1_ENST00000504948.1_Silent_p.I721I|ATP2C1_ENST00000328560.8_Silent_p.I737I|ATP2C1_ENST00000504381.1_Silent_p.I682I|ATP2C1_ENST00000428331.2_Silent_p.I737I			P98194	AT2C1_HUMAN	ATPase, Ca++ transporting, type 2C, member 1	737					actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|prostate(2)|skin(2)|urinary_tract(1)	39					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	TTTTGTGGATCAATATTATTA	0.368000									Hailey-Hailey disease				17	98					0	0	0.000422831	0	0
PSD4	23550	broad.mit.edu	37	2	113942615	113942615	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:113942615G>A	ENST00000245796.6	+	3	1333	c.1138G>A	c.(1138-1140)Gat>Aat	p.D380N	PSD4_ENST00000441564.2_Missense_Mutation_p.D380N	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	380					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						tgtcggatctgatcttggccc	0.537000													25	55					0	0	0.00047179	0	0
ULK4	54986	broad.mit.edu	37	3	41961305	41961305	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:41961305G>A	ENST00000301831.4	-	6	1009	c.547C>T	c.(547-549)Cct>Tct	p.P183S	ULK4_ENST00000420927.1_Missense_Mutation_p.P183S	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	183	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GTATATACAGGAGATCCTAAA	0.443000													24	44					0	0	0.00047179	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766705	77766705	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:77766705C>T	ENST00000521891.2	+	10	7996	c.7548C>T	c.(7546-7548)ttC>ttT	p.F2516F	ZFHX4_ENST00000518282.1_Silent_p.F2490F|ZFHX4_ENST00000455469.2_Silent_p.F2471F|ZFHX4_ENST00000050961.6_Silent_p.F2471F	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2471						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACATGCACTTCCTTGCTGCTC	0.483000										HNSCC(33;0.089)			14	221					0	0	5.01169e-05	0	0
PITPNM2	57605	broad.mit.edu	37	12	123497242	123497242	+	Silent	SNP	A	A	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:123497242A>T	ENST00000280562.5	-	4	538	c.333T>A	c.(331-333)atT>atA	p.I111I	PITPNM2_ENST00000451868.2_5'UTR|PITPNM2_ENST00000320201.4_Silent_p.I111I|PITPNM2_ENST00000546049.1_Silent_p.I111I|PITPNM2_ENST00000542749.1_Silent_p.I111I|PITPNM2_ENST00000392428.1_Intron			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	111					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		AAAAGGTTTCAATGTCGATGG	0.502000													73	59					0	0	0.000147903	0	0
STK11	6794	broad.mit.edu	37	19	1218458	1218458	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:1218458C>T	ENST00000326873.7	+	2	1506	c.333C>T	c.(331-333)atC>atT	p.I111I	STK11_ENST00000585748.1_3'UTR	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	111	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(3)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		AAAATGTCATCCAGCTGGTGG	0.557000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			53	116					0	0	0.000147903	0	0
GPR142	350383	broad.mit.edu	37	17	72368703	72368703	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:72368703G>A	ENST00000335666.4	+	4	1401	c.1353G>A	c.(1351-1353)atG>atA	p.M451I		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	451						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						AGCCTGTGATGGAGCCTCCGG	0.632000													14	17					0	0	0.000422831	0	0
ALPK1	80216	broad.mit.edu	37	4	113353542	113353542	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:113353542C>T	ENST00000458497.1	+	11	3118	c.2839C>T	c.(2839-2841)Cct>Tct	p.P947S	ALPK1_ENST00000504176.2_Missense_Mutation_p.P869S|ALPK1_ENST00000177648.9_Missense_Mutation_p.P947S	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	947	Ser-rich.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		GGGGGACAGCCCTTGGTCCTA	0.512000													11	33					0	0	3.86212e-05	0	0
PREX2	80243	broad.mit.edu	37	8	68992729	68992729	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:68992729C>T	ENST00000288368.4	+	16	1971	c.1694C>T	c.(1693-1695)tCg>tTg	p.S565L	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	565	DEP 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity	p.S565L(2)		NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CGTTTTTTTTCGGATGAGGAA	0.323000													10	123					0	0	0.00010058	0	0
NRP1	8829	broad.mit.edu	37	10	33510678	33510678	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:33510678C>T	ENST00000265371.4	-	9	1776	c.1251G>A	c.(1249-1251)atG>atA	p.M417I	NRP1_ENST00000395995.1_Missense_Mutation_p.M417I|NRP1_ENST00000374816.3_Missense_Mutation_p.M417I|NRP1_ENST00000374821.5_Missense_Mutation_p.M417I|NRP1_ENST00000374822.4_Missense_Mutation_p.M417I|NRP1_ENST00000374823.5_Missense_Mutation_p.M417I|NRP1_ENST00000374867.2_Missense_Mutation_p.M417I			O14786	NRP1_HUMAN	neuropilin 1	417	F5/8 type C 1.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	CTTCAAATCTCATAGATATGC	0.418000													35	73					0	0	0.000191422	0	0
LILRA2	11027	broad.mit.edu	37	19	55086779	55086779	+	Missense_Mutation	SNP	G	G	A	rs139468214		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:55086779G>A	ENST00000251377.3	+	6	845	c.712G>A	c.(712-714)Gag>Aag	p.E238K	LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000251376.3_Missense_Mutation_p.E238K|LILRA2_ENST00000391737.1_Missense_Mutation_p.E226K|LILRA2_ENST00000391738.3_Missense_Mutation_p.E238K|LILRB1_ENST00000448689.1_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		GGCCCCCGGGGAGAGCCTGAC	0.572000													14	69					0	0	9.7654e-05	0	0
CREB5	9586	broad.mit.edu	37	7	28534569	28534569	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:28534569G>A	ENST00000357727.2	+	3	511	c.121G>A	c.(121-123)Gaa>Aaa	p.E41K	CREB5_ENST00000409603.1_Missense_Mutation_p.E8K|CREB5_ENST00000396300.2_Missense_Mutation_p.E34K|CREB5_ENST00000396299.2_Missense_Mutation_p.E8K	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	41					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						GCACAAACATGAAATGACTTT	0.413000													153	277					0	0	0.000147903	0	0
NLRC4	58484	broad.mit.edu	37	2	32476336	32476336	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:32476336G>A	ENST00000404025.2	-	5	1085	c.597C>T	c.(595-597)ttC>ttT	p.F199F	NLRC4_ENST00000402280.1_Silent_p.F199F|NLRC4_ENST00000360906.5_Silent_p.F199F|NLRC4_ENST00000342905.6_Intron			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	199	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GGAAGAAGACGAATTTGAACT	0.517000													16	36					0	0	0.000422831	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94670672	94670672	+	Silent	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:94670672A>C	ENST00000260526.6	-	7	824	c.642T>G	c.(640-642)acT>acG	p.T214T	ARHGAP29_ENST00000370217.3_Silent_p.T214T	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	214					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		ATTTTGACCAAGTTTTAGCAT	0.328000													13	88					0	0	0.000219431	0	0
MAN1A1	4121	broad.mit.edu	37	6	119611861	119611861	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:119611861A>C	ENST00000368468.3	-	5	1325	c.884T>G	c.(883-885)cTg>cGg	p.L295R	MAN1A1_ENST00000368466.2_Missense_Mutation_p.L318R	NM_005907.3	NP_005898.2	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	295					post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|skin(3)	24		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		TTCTCCAGACAGATAGTAGGC	0.308000													14	43					0	0	9.7654e-05	0	0
KIAA1549	57670	broad.mit.edu	37	7	138596002	138596002	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:138596002G>A	ENST00000440172.1	-	4	3083	c.3035C>T	c.(3034-3036)tCc>tTc	p.S1012F	KIAA1549_ENST00000422774.1_Missense_Mutation_p.S1012F|KIAA1549_ENST00000242365.4_Missense_Mutation_p.S962F	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1012						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						ATTTATGACGGATATTGCCGT	0.398000			O	BRAF	pilocytic astrocytoma								21	15					0	0	0.000375601	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870393	51870393	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:51870393C>T	ENST00000371497.5	+	2	1283	c.396C>T	c.(394-396)atC>atT	p.I132I	TSHZ2_ENST00000603338.2_Silent_p.I129I|TSHZ2_ENST00000329613.6_Silent_p.I129I	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	132					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			ACGCCAACATCCTGTCGGATT	0.522000													7	62					0	0	0.000157383	0	0
SCN11A	11280	broad.mit.edu	37	3	38889195	38889195	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:38889195G>A	ENST00000302328.3	-	26	4564	c.4366C>T	c.(4366-4368)Cct>Tct	p.P1456S	SCN11A_ENST00000450244.1_Missense_Mutation_p.P1456S|SCN11A_ENST00000456224.3_Missense_Mutation_p.P1418S	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1456					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GGAGGGAAAGGAATGTGCTCC	0.502000													10	10					0	0	3.86212e-05	0	0
SENP7	57337	broad.mit.edu	37	3	101212726	101212726	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:101212726G>A	ENST00000394095.2	-	3	230	c.177C>T	c.(175-177)ctC>ctT	p.L59L	SENP7_ENST00000314261.7_Silent_p.L59L|SENP7_ENST00000394091.1_Silent_p.L26L|SENP7_ENST00000348610.3_Silent_p.L26L|SENP7_ENST00000358203.3_Silent_p.L26L|SENP7_ENST00000394094.2_Silent_p.L59L	NM_020654.3	NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7	59					proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						CCTGCAAAGGGAGAGTCCAGC	0.303000													28	82					0	0	0.000339439	0	0
BAZ2A	11176	broad.mit.edu	37	12	56997418	56997418	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:56997418G>A	ENST00000179765.5	-	18	3214	c.3015C>T	c.(3013-3015)tgC>tgT	p.C1005C	BAZ2A_ENST00000379441.3_Silent_p.C1007C|BAZ2A_ENST00000551812.1_Silent_p.C1037C|BAZ2A_ENST00000549884.1_Silent_p.C1035C			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	1037					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						TCCGTCCCAGGCATTCCTCTG	0.552000													16	74					0	0	7.07596e-05	0	0
USH1C	10083	broad.mit.edu	37	11	17517217	17517217	+	Missense_Mutation	SNP	G	G	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:17517217G>C	ENST00000005226.7	-	26	2553	c.2554C>G	c.(2554-2556)Ctt>Gtt	p.L852V	USH1C_ENST00000318024.4_Intron|USH1C_ENST00000527020.1_Intron|USH1C_ENST00000527720.1_Intron|USH1C_ENST00000529563.1_Intron	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	0					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						GAGGAGGGAAGAGAAGCTCTA	0.572000													15	78					0	0	0.000422831	0	0
CPXM2	119587	broad.mit.edu	37	10	125521563	125521563	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:125521563C>T	ENST00000241305.3	-	11	1756	c.1602G>A	c.(1600-1602)tgG>tgA	p.W534*	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	534					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CCTGCGTCTTCCAGGGGGACC	0.642000													15	34					0	0	0.000308642	0	0
CD1E	913	broad.mit.edu	37	1	158325625	158325625	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:158325625G>A	ENST00000444681.2	+	3	630	c.337G>A	c.(337-339)Gag>Aag	p.E113K	CD1E_ENST00000368166.3_Missense_Mutation_p.E23K|CD1E_ENST00000368155.3_Missense_Mutation_p.E122K|CD1E_ENST00000452291.2_Missense_Mutation_p.E23K|CD1E_ENST00000368163.3_Missense_Mutation_p.E212K|CD1E_ENST00000368160.3_Missense_Mutation_p.E212K|CD1E_ENST00000368164.3_Missense_Mutation_p.E23K|CD1E_ENST00000368154.1_Missense_Mutation_p.E23K|CD1E_ENST00000368167.3_Missense_Mutation_p.E212K|CD1E_ENST00000368157.1_Missense_Mutation_p.E23K|CD1E_ENST00000368156.1_Missense_Mutation_p.E122K|CD1E_ENST00000368161.3_Missense_Mutation_p.E212K|CD1E_ENST00000434258.1_Missense_Mutation_p.E210K|CD1E_ENST00000368165.3_Missense_Mutation_p.E122K	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	212					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					AGTGAAGCCAGAGGCCTGGCT	0.522000													7	10					0	0	0.000274275	0	0
SPN	6693	broad.mit.edu	37	16	29675698	29675698	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:29675698G>A	ENST00000360121.3	+	2	741	c.649G>A	c.(649-651)Ggg>Agg	p.G217R	AC009133.19_ENST00000449759.1_Intron|SPN_ENST00000395389.2_Missense_Mutation_p.G217R	NM_001030288.2|NM_003123.4	NP_001025459.1|NP_003114.1	P16150	LEUK_HUMAN	sialophorin	217					blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|stomach(1)	15						GCCCTCCAGCGGGGCCAGTGG	0.577000													33	45					0	0	0.000109025	0	0
GPR112	139378	broad.mit.edu	37	X	135480047	135480047	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:135480047C>T	ENST00000394143.1	+	20	8483	c.8192C>T	c.(8191-8193)tCc>tTc	p.S2731F	GPR112_ENST00000412101.1_Missense_Mutation_p.S2526F|GPR112_ENST00000394141.1_Missense_Mutation_p.S2526F|GPR112_ENST00000370652.1_Missense_Mutation_p.S2731F|GPR112_ENST00000287534.4_Missense_Mutation_p.S2484F	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2731	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TAGGATTTATCCAGGTCTACA	0.418000													22	45					0	0	7.16444e-05	0	0
MEOX1	4222	broad.mit.edu	37	17	41719371	41719371	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:41719371C>T	ENST00000318579.4	-	3	1091	c.672G>A	c.(670-672)atG>atA	p.M224I	MEOX1_ENST00000393661.2_Missense_Mutation_p.M109I|MEOX1_ENST00000549132.1_Missense_Mutation_p.M137I|MEOX1_ENST00000329168.3_Missense_Mutation_p.E167K	NM_001040002.1|NM_004527.3	NP_001035091.1|NP_004518.1	P50221	MEOX1_HUMAN	mesenchyme homeobox 1	224						nucleus	sequence-specific DNA binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	8		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0753)		GCTTCCACTTCATCCTTCGGT	0.582000													20	90					0	0	0.00047179	0	0
BSND	7809	broad.mit.edu	37	1	55473941	55473941	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:55473941G>A	ENST00000371265.4	+	4	857	c.603G>A	c.(601-603)ctG>ctA	p.L201L		NM_057176.2	NP_476517.1	Q8WZ55	BSND_HUMAN	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	201						basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17						AAGATGACCTGGACATGGACT	0.607000													4	37					0	0	3.59834e-05	0	0
SSFA2	6744	broad.mit.edu	37	2	182780931	182780931	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:182780931A>G	ENST00000431877.2	+	11	2743	c.2564A>G	c.(2563-2565)gAa>gGa	p.E855G	SSFA2_ENST00000320370.7_Missense_Mutation_p.E855G|SSFA2_ENST00000428267.2_Missense_Mutation_p.E702G|SSFA2_ENST00000409001.1_Missense_Mutation_p.E855G|SSFA2_ENST00000409136.1_Missense_Mutation_p.E364G	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	855						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			GAGTGGCAAGAAAGGCCCCTG	0.527000													14	35					0	0	0.000422831	0	0
FGD2	221472	broad.mit.edu	37	6	36976697	36976697	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:36976697G>A	ENST00000274963.8	+	2	327	c.156G>A	c.(154-156)cgG>cgA	p.R52R		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	52					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						CAGGACCACGGGAGAAGACGA	0.632000													9	26					0	0	0.000274275	0	0
GJC2	57165	broad.mit.edu	37	1	228346248	228346248	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:228346248A>C	ENST00000366714.2	+	2	964	c.789A>C	c.(787-789)gaA>gaC	p.E263D		NM_020435.3	NP_065168.2	Q5T442	CXG2_HUMAN	gap junction protein, gamma 2, 47kDa	263					cell death	connexon complex|integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7		Prostate(94;0.0405)				GCCCTACTGAAAAGACGGTCT	0.637000													16	67					0	0	0.000132079	0	0
ADAM29	11086	broad.mit.edu	37	4	175897101	175897101	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:175897101C>T	ENST00000359240.3	+	5	1095	c.425C>T	c.(424-426)tCt>tTt	p.S142F	ADAM29_ENST00000404450.4_Missense_Mutation_p.S142F|ADAM29_ENST00000445694.1_Missense_Mutation_p.S142F|ADAM29_ENST00000514159.1_Missense_Mutation_p.S142F	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	142					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CTAGCATTTTCTACCACGTTT	0.398000													10	21					0	0	3.86212e-05	0	0
SDE2	163859	broad.mit.edu	37	1	226178949	226178949	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:226178949G>A	ENST00000272091.7	-	5	654	c.636C>T	c.(634-636)tgC>tgT	p.C212C	SDE2_ENST00000366817.1_Silent_p.C117C	NM_152608.3	NP_689821.3			SDE2 telomere maintenance homolog (S. pombe)																		CTTACCAGAAGCATCTCCTCT	0.438000													14	52					0	0	5.01169e-05	0	0
DOCK3	1795	broad.mit.edu	37	3	51312577	51312577	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:51312577G>A	ENST00000266037.9	+	25	2639	c.2616G>A	c.(2614-2616)gaG>gaA	p.E872E		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	872						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		AGCAGAAAGAGCTGCTAATTT	0.517000													66	129					0	0	0.000147903	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185936	127185936	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:127185936C>T	ENST00000371124.3	-	1	446	c.250G>A	c.(250-252)Gac>Aac	p.D84N		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	84						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						TTCTCCATGTCATCCCATCCT	0.493000													33	23					0	0	0.000191422	0	0
ALDH16A1	126133	broad.mit.edu	37	19	49963009	49963009	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:49963009C>T	ENST00000293350.4	+	4	566	c.403C>T	c.(403-405)Cga>Tga	p.R135*	ALDH16A1_ENST00000455361.2_Nonsense_Mutation_p.R135*|ALDH16A1_ENST00000540132.1_Intron|ALDH16A1_ENST00000433981.2_5'UTR	NM_153329.3	NP_699160.2	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	135							oxidoreductase activity|protein binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|skin(2)|urinary_tract(3)	20		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		TCGAGAGGTTCGAGACGGGGA	0.642000													11	29					0	0	3.86212e-05	0	0
XIST	7503	broad.mit.edu	37	X	73063860	73063860	+	RNA	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:73063860G>A	ENST00000429829.1	-	0	8728					NR_001564.2																						GAAGTGATAGGGTTGTGGACA	0.418000													6	15					0	0	3.59834e-05	0	0
BZRAP1	9256	broad.mit.edu	37	17	56400098	56400098	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:56400098C>T	ENST00000355701.3	-	9	2104	c.1234G>A	c.(1234-1236)Ggg>Agg	p.G412R	BZRAP1_ENST00000343736.4_Missense_Mutation_p.G412R|BZRAP1_ENST00000268893.6_Missense_Mutation_p.G352R	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	412						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGTGTCACCCCCAGGAGCTGG	0.647000													21	19					0	0	0.000375601	0	0
PAK3	5063	broad.mit.edu	37	X	110406200	110406200	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:110406200G>A	ENST00000519681.1	+	10	1031	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	PAK3_ENST00000360648.4_Missense_Mutation_p.E212K|PAK3_ENST00000417227.1_Missense_Mutation_p.E197K|PAK3_ENST00000262836.4_Missense_Mutation_p.E191K|PAK3_ENST00000446737.1_Missense_Mutation_p.E176K|PAK3_ENST00000372010.1_Missense_Mutation_p.E191K|PAK3_ENST00000518291.1_Missense_Mutation_p.E212K|PAK3_ENST00000425146.1_Missense_Mutation_p.E176K|PAK3_ENST00000372007.4_Missense_Mutation_p.E176K			O75914	PAK3_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 3	191	Linker.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						agaagaagatgaagaggaaga	0.408000										TSP Lung(19;0.15)			20	30					0	0	0.000132079	0	0
ZNF681	148213	broad.mit.edu	37	19	23927533	23927533	+	Silent	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:23927533T>C	ENST00000402377.3	-	4	960	c.819A>G	c.(817-819)acA>acG	p.T273T	ZNF681_ENST00000395385.3_Silent_p.T204T	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	273					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TATGAATTATTGTATGTGTTG	0.353000													21	102					0	0	0.000375601	0	0
UBE3C	9690	broad.mit.edu	37	7	156974866	156974866	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:156974866C>T	ENST00000348165.5	+	8	1195	c.835C>T	c.(835-837)Cat>Tat	p.H279Y	UBE3C_ENST00000389103.4_Missense_Mutation_p.H236Y	NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	279					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		TCAGATTTTTCATTTCATCAT	0.398000													39	109					0	0	0.000147903	0	0
CLGN	1047	broad.mit.edu	37	4	141334224	141334224	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:141334224G>A	ENST00000325617.5	-	2	449	c.9C>T	c.(7-9)ttC>ttT	p.F3F	CLGN_ENST00000537281.1_Silent_p.F3F|CLGN_ENST00000414773.1_Silent_p.F3F	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	3					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding	p.F3F(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					AAAAGGCTTGGAAATGCATAT	0.284000													15	95					0	0	9.7654e-05	0	0
CHAD	1101	broad.mit.edu	37	17	48545637	48545637	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:48545637C>T	ENST00000508540.1	-	1	690	c.538G>A	c.(538-540)Gaa>Aaa	p.E180K	ACSF2_ENST00000427954.2_Intron|ACSF2_ENST00000541920.1_Intron|ACSF2_ENST00000502667.1_Intron|ACSF2_ENST00000504392.1_Intron|CHAD_ENST00000258969.4_Missense_Mutation_p.E180K|ACSF2_ENST00000300441.4_Intron	NM_001267.2	NP_001258.2	O15335	CHAD_HUMAN	chondroadherin	180					regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(2)|ovary(2)	15	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			AACGCGTTTTCCGACAGGTAG	0.617000													47	48					0	0	0.000147903	0	0
FLNC	2318	broad.mit.edu	37	7	128496603	128496603	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:128496603C>T	ENST00000325888.8	+	44	7544	c.7283C>T	c.(7282-7284)tCc>tTc	p.S2428F	RP11-309L24.2_ENST00000469965.1_RNA|FLNC_ENST00000346177.6_Missense_Mutation_p.S2395F	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2428	Interaction with INPPL1.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CAGCCAGCGTCCTTTGCCGTG	0.652000													6	47					0	0	0.000274275	0	0
POLQ	10721	broad.mit.edu	37	3	121208690	121208690	+	Missense_Mutation	SNP	A	A	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:121208690A>T	ENST00000264233.5	-	16	3216	c.3088T>A	c.(3088-3090)Ttc>Atc	p.F1030I		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	1030					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		TCTGAATTGAAATTCAAAGGT	0.413000								DNA polymerases (catalytic subunits)					33	93					0	0	0.000409698	0	0
C6	729	broad.mit.edu	37	5	41149408	41149408	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:41149408G>A	ENST00000263413.3	-	17	2822	c.2558C>T	c.(2557-2559)tCa>tTa	p.S853L	C6_ENST00000337836.5_Missense_Mutation_p.S853L	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	853	C5b-binding domain.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GCTGTTGGATGAAAGTCTTGT	0.423000													38	47					0	0	0.000159656	0	0
BECN1	8678	broad.mit.edu	37	17	40971575	40971575	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:40971575G>A	ENST00000361523.4	-	4	383	c.251C>T	c.(250-252)cCc>cTc	p.P84L	BECN1_ENST00000438274.3_Missense_Mutation_p.P84L|BECN1_ENST00000590099.1_Missense_Mutation_p.P84L	NM_003766.3	NP_003757.1	Q14457	BECN1_HUMAN	beclin 1, autophagy related	84					anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	13		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		CCTGGCTGGGGGGATGAATCT	0.488000											OREG0024429	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	31					0	0	0.000274275	0	0
ZNF792	126375	broad.mit.edu	37	19	35450222	35450222	+	Missense_Mutation	SNP	C	C	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:35450222C>G	ENST00000404801.1	-	4	923	c.537G>C	c.(535-537)caG>caC	p.Q179H	ZNF792_ENST00000605484.1_Missense_Mutation_p.Q112H	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TCTGCTGCACCTGTTTCCGGG	0.517000													7	230					0	0	3.86212e-05	0	0
SCN1A	6323	broad.mit.edu	37	2	166848514	166848514	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:166848514C>T	ENST00000423058.2	-	26	5288	c.5271G>A	c.(5269-5271)ggG>ggA	p.G1757G	SCN1A_ENST00000409050.1_Silent_p.G1729G|AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Silent_p.G1757G|SCN1A_ENST00000375405.3_Silent_p.G1746G	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1757						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CAGATGGGTTCCCACAGTCTC	0.468000													22	16					0	0	0.00047179	0	0
GRIK1	2897	broad.mit.edu	37	21	30925914	30925914	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr21:30925914T>C	ENST00000399907.1	-	17	3130	c.2719A>G	c.(2719-2721)Aga>Gga	p.R907G	GRIK1_ENST00000399913.1_Intron|GRIK1_ENST00000309434.7_Missense_Mutation_p.R909G|GRIK1_ENST00000399914.1_Intron|GRIK1_ENST00000389125.3_Intron|GRIK1_ENST00000399909.1_Missense_Mutation_p.R892G|GRIK1_ENST00000327783.4_Intron|GRIK1_ENST00000535441.1_Intron|GRIK1_ENST00000389124.2_Intron	NM_000830.3	NP_000821.1	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	907					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CGAATCCCTCTCTCCTCTCGA	0.358000													21	71					0	0	0.000175454	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95108095	95108095	+	RNA	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:95108095G>A	ENST00000469935.1	+	0	700					NR_015340.1																						GCCTGGGCGCGAGGGCCAACC	0.632000													11	46					0	0	0.00010058	0	0
GPD1L	23171	broad.mit.edu	37	3	32200591	32200591	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:32200591G>A	ENST00000282541.5	+	6	1043	c.842G>A	c.(841-843)aGa>aAa	p.R281K		NM_015141.3	NP_055956.1	Q8N335	GPD1L_HUMAN	glycerol-3-phosphate dehydrogenase 1-like	281					glycerol-3-phosphate catabolic process	glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|NAD binding|protein homodimerization activity			large_intestine(4)|lung(7)|ovary(1)	12						GCCTTCGCCAGAACTGGGAAG	0.627000													8	23					0	0	0.000157383	0	0
CLNK	116449	broad.mit.edu	37	4	10515113	10515113	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:10515113G>A	ENST00000226951.6	-	16	1120	c.881C>T	c.(880-882)cCt>cTt	p.P294L	CLNK_ENST00000515667.1_Missense_Mutation_p.P32L	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker	294					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						TTTGGGGAAAGGTGGTCTCCA	0.493000													6	28					0	0	0.000157383	0	0
GATA2	2624	broad.mit.edu	37	3	128205201	128205201	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:128205201G>A	ENST00000341105.2	-	3	571	c.240C>T	c.(238-240)acC>acT	p.T80T	GATA2_ENST00000430265.2_Silent_p.T80T|GATA2_ENST00000487848.1_Silent_p.T80T	NM_032638.4	NP_116027.2	P23769	GATA2_HUMAN	GATA binding protein 2	80					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(58)|kidney(2)|large_intestine(3)|lung(9)|prostate(3)|skin(1)|urinary_tract(1)	79				GBM - Glioblastoma multiforme(114;0.173)		TCTGGCCTCCGGTCAGGCGGG	0.647000			Mis		AML(CML blast transformation)								4	13					0	0	8.12818e-05	0	0
HIST1H3G	8355	broad.mit.edu	37	6	26271219	26271219	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:26271219G>A	ENST00000305910.3	-	1	393	c.394C>T	c.(394-396)Cgt>Tgt	p.R132C		NM_003534.2	NP_003525.1	P68431	H31_HUMAN	histone cluster 1, H3g	132					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12						CTCTCCCCACGAATGCGGCGA	0.502000													9	77					0	0	0.000151284	0	0
IGHV3-38	28429	broad.mit.edu	37	14	106866589	106866589	+	RNA	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:106866589C>T	ENST00000390618.2	-	0	242																											CCTGGCGGATCCAGCTCATCT	0.582000													5	24					0	0	8.12818e-05	0	0
F7	2155	broad.mit.edu	37	13	113771173	113771173	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr13:113771173G>A	ENST00000375581.3	+	7	700	c.665G>A	c.(664-666)gGg>gAg	p.G222E	F7_ENST00000346342.3_Missense_Mutation_p.G200E|F7_ENST00000541084.1_Missense_Mutation_p.G153E	NM_000131.4	NP_000122.1	P08709	FA7_HUMAN	coagulation factor VII (serum prothrombin conversion accelerator)	222	Peptidase S1.				anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity			large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	TGCCCCAAAGGGGAGTGTCCA	0.488000													12	44					0	0	0.000151284	0	0
UNC5D	137970	broad.mit.edu	37	8	35541129	35541129	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:35541129C>T	ENST00000287272.2	+	5	655	c.635C>T	c.(634-636)gCt>gTt	p.A212V	UNC5D_ENST00000416672.1_Missense_Mutation_p.A212V|UNC5D_ENST00000453357.2_Missense_Mutation_p.A207V|UNC5D_ENST00000420357.1_Missense_Mutation_p.A212V|UNC5D_ENST00000404895.2_Missense_Mutation_p.A212V			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	212	Ig-like C2-type.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GACACCAGGGCTGACCATAAC	0.493000													7	71					0	0	0.000274275	0	0
DDX60L	91351	broad.mit.edu	37	4	169327209	169327209	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:169327209G>A	ENST00000511577.1	-	24	3352	c.3105C>T	c.(3103-3105)ttC>ttT	p.F1035F	DDX60L_ENST00000505890.1_Silent_p.F1035F|DDX60L_ENST00000260184.7_Silent_p.F1035F			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1035							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TAAAAAGAATGAATTCCTCTG	0.294000													6	27					0	0	0.000157383	0	0
TMTC1	83857	broad.mit.edu	37	12	29667498	29667498	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:29667498T>C	ENST00000256062.5	-	16	2496	c.2023A>G	c.(2023-2025)Aag>Gag	p.K675E	TMTC1_ENST00000539277.1_Missense_Mutation_p.K783E|TMTC1_ENST00000552618.1_Missense_Mutation_p.K807E|TMTC1_ENST00000319685.8_5'UTR|TMTC1_ENST00000551659.1_Missense_Mutation_p.K845E	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	783						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TTTGGGTCCTTTGGTTTCAGC	0.358000													7	75					0	0	0.000274275	0	0
MYO15A	51168	broad.mit.edu	37	17	18051478	18051478	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:18051478G>A	ENST00000205890.5	+	31	6983	c.6645G>A	c.(6643-6645)gcG>gcA	p.A2215A		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	2215	MyTH4 1.|Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					AGTGGACAGCGACCTATGAGA	0.667000													14	13					0	0	0.000308642	0	0
ALPK1	80216	broad.mit.edu	37	4	113353543	113353543	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:113353543C>T	ENST00000458497.1	+	11	3119	c.2840C>T	c.(2839-2841)cCt>cTt	p.P947L	ALPK1_ENST00000504176.2_Missense_Mutation_p.P869L|ALPK1_ENST00000177648.9_Missense_Mutation_p.P947L	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	947	Ser-rich.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		GGGGACAGCCCTTGGTCCTAT	0.507000													11	33					0	0	3.86212e-05	0	0
OR13C2	392376	broad.mit.edu	37	9	107367383	107367383	+	Missense_Mutation	SNP	G	G	A	rs149514294		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:107367383G>A	ENST00000542196.1	-	1	568	c.526C>T	c.(526-528)Cat>Tat	p.H176Y		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H176Y(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CAGGTGAAATGATTGATGATG	0.443000													15	51					0	0	9.7654e-05	0	0
GPATCH3	63906	broad.mit.edu	37	1	27217608	27217608	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:27217608C>T	ENST00000361720.5	-	7	1494	c.1471G>A	c.(1471-1473)Gag>Aag	p.E491K		NM_022078.2	NP_071361.2	Q96I76	GPTC3_HUMAN	G patch domain containing 3	491						intracellular	nucleic acid binding			endometrium(2)|large_intestine(1)|lung(11)|skin(1)	15		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.97e-51)|OV - Ovarian serous cystadenocarcinoma(117;9.55e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|STAD - Stomach adenocarcinoma(196;0.000595)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|READ - Rectum adenocarcinoma(331;0.0419)		AGCAGTGACTCCGTCTGGTCT	0.567000													14	19					0	0	0.000422831	0	0
CREB3L1	90993	broad.mit.edu	37	11	46341862	46341862	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:46341862G>A	ENST00000529193.1	+	11	1757	c.1306G>A	c.(1306-1308)Gaa>Aaa	p.E436K	CREB3L1_ENST00000288400.3_Missense_Mutation_p.E436K			Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like 1	436					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	NS(2)|breast(1)|large_intestine(4)|lung(2)|ovary(3)	12				GBM - Glioblastoma multiforme(35;0.0285)		AGGCTTATGGGAAGATGGCCG	0.647000			T	FUS	myxofibrosarcoma								6	8					0	0	0.000274275	0	0
FRMD7	90167	broad.mit.edu	37	X	131228143	131228143	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:131228143C>T	ENST00000298542.4	-	5	484	c.309G>A	c.(307-309)aaG>aaA	p.K103K	FRMD7_ENST00000370879.1_5'UTR|FRMD7_ENST00000464296.1_Silent_p.K88K	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	103	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					CCAAATCCTTCTTTATTTGAA	0.388000													16	49					0	0	7.07596e-05	0	0
FCRL1	115350	broad.mit.edu	37	1	157773804	157773804	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:157773804G>A	ENST00000358292.3	-	3	201	c.150C>T	c.(148-150)ttC>ttT	p.F50F	FCRL1_ENST00000491942.1_Silent_p.F50F|FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000368176.3_Silent_p.F50F	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	50	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AGCAGAACTGGAACTGGGCAT	0.567000													13	31					0	0	0.00010058	0	0
OR5K4	403278	broad.mit.edu	37	3	98073124	98073124	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:98073124C>T	ENST00000354924.2	+	1	427	c.427C>T	c.(427-429)Cgg>Tgg	p.R143W	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005517.1	NP_001005517.1	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K, member 4	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	21						GCTCTGCATTCGGATGACCAC	0.478000													9	42					0	0	0.000442599	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4455280	4455280	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:4455280G>A	ENST00000254718.4	-	8	1224	c.918C>T	c.(916-918)ttC>ttT	p.F306F	MYBBP1A_ENST00000381556.2_Silent_p.F306F			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a	306	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)	24						CCAGCAGGCGGAAACACAGGT	0.642000													19	53					0	0	0.000295444	0	0
DMBT1	1755	broad.mit.edu	37	10	124395566	124395566	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:124395566C>T	ENST00000338354.3	+	50	6327	c.6221C>T	c.(6220-6222)tCc>tTc	p.S2074F	DMBT1_ENST00000330163.4_Missense_Mutation_p.S1446F|DMBT1_ENST00000344338.3_Missense_Mutation_p.S2064F|DMBT1_ENST00000359586.6_Missense_Mutation_p.S794F|DMBT1_ENST00000368956.2_Missense_Mutation_p.S1446F|DMBT1_ENST00000368955.3_Missense_Mutation_p.S2064F|DMBT1_ENST00000368909.3_Missense_Mutation_p.S2074F			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2074	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TACCGCAGTTCCCCTCTCATT	0.502000													13	49					0	0	0.000219431	0	0
VCAN	1462	broad.mit.edu	37	5	82815664	82815664	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:82815664C>T	ENST00000265077.3	+	7	2104	c.1539C>T	c.(1537-1539)ttC>ttT	p.F513F	VCAN_ENST00000512590.2_Silent_p.F465F|VCAN_ENST00000343200.5_Intron|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000342785.4_Silent_p.F513F	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	513	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CCAAGGAATTCCCTGTAACTG	0.378000													20	65					0	0	0.000375601	0	0
LUZP2	338645	broad.mit.edu	37	11	24750756	24750756	+	Missense_Mutation	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:24750756T>A	ENST00000336930.6	+	2	170	c.104T>A	c.(103-105)tTt>tAt	p.F35Y	LUZP2_ENST00000531187.1_3'UTR|LUZP2_ENST00000533227.1_5'UTR			Q86TE4	LUZP2_HUMAN	leucine zipper protein 2	35						extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(11)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	32						AAAGAAGTCTTTAAGGAGCGA	0.433000													6	40					0	0	0.000157383	0	0
ZEB1	6935	broad.mit.edu	37	10	31803585	31803585	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:31803585A>T	ENST00000446923.2	+	6	1082	c.691A>T	c.(691-693)Aaa>Taa	p.K231*	ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000361642.5_Nonsense_Mutation_p.K248*|ZEB1_ENST00000320985.10_Nonsense_Mutation_p.K247*|ZEB1_ENST00000542815.3_Nonsense_Mutation_p.K180*|ZEB1_ENST00000560721.2_Nonsense_Mutation_p.K227*	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	247					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				TGAGTGTGGAAAAGCTTTCAA	0.328000													15	51					0	0	9.7654e-05	0	0
KCNB2	9312	broad.mit.edu	37	8	73849053	73849053	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:73849053C>T	ENST00000523207.1	+	3	2051	c.1463C>T	c.(1462-1464)tCg>tTg	p.S488L		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	488					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			AATCACCTGTCGCCAAGCCGG	0.527000													25	163					0	0	0.00047179	0	0
CCDC158	339965	broad.mit.edu	37	4	77253640	77253640	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:77253640C>T	ENST00000388914.3	-	19	2967	c.2815G>A	c.(2815-2817)Gat>Aat	p.D939N		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	939										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						CTTACCCTATCCTCTCTGTAT	0.308000													27	38					0	0	0.000409698	0	0
IGHV3-64	28414	broad.mit.edu	37	14	107113761	107113761	+	RNA	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:107113761C>T	ENST00000454421.2	-	0	410																											TAATACACAGCCATGTCCTCA	0.512000													8	73					0	0	0.000442599	0	0
TTK	7272	broad.mit.edu	37	6	80744798	80744798	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:80744798G>A	ENST00000509894.1	+	15	2537	c.1708G>A	c.(1708-1710)Gaa>Aaa	p.E570K	TTK_ENST00000230510.3_Missense_Mutation_p.E570K|TTK_ENST00000369798.2_Missense_Mutation_p.E571K			P33981	TTK_HUMAN	TTK protein kinase	571	Protein kinase.				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E555K(1)		endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TTACCGGAACGAAATAGCTTA	0.284000													25	62					0	0	9.22233e-05	0	0
TBC1D5	9779	broad.mit.edu	37	3	17349625	17349625	+	Splice_Site	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:17349625T>C	ENST00000253692.7	-	14	2661	c.995_splice	c.e14-1	p.R333_splice	TBC1D5_ENST00000429383.4_Splice_Site_p.R333_splice|TBC1D5_ENST00000446818.2_Splice_Site_p.R333_splice|TBC1D5_ENST00000429924.2_Splice_Site_p.R285_splice|TBC1D5_ENST00000414318.2_5'UTR	NM_014744.2	NP_055559.1	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5	333	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	36						CGCACCCACCTTCTGGAAAGA	0.443000													9	9					0	0	3.86212e-05	0	0
ERVW-1	30816	broad.mit.edu	37	7	92099170	92099170	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:92099170G>T	ENST00000493463.2	-	1	1449	c.526C>A	c.(526-528)Cat>Aat	p.H176N	AC007566.10_ENST00000427458.1_RNA|ERVW-1_ENST00000603053.1_Missense_Mutation_p.H176N|ERVW-1_ENST00000604270.1_Intron	NM_014590.3	NP_055405.3	Q9UQF0	ENW1_HUMAN		176					syncytium formation	integral to membrane|plasma membrane|virion				endometrium(1)|large_intestine(1)|lung(15)	17						gagacctcatggagcccagtg	0.483000													14	35					2.32078e-09	4.86454e-08	0.000308642	1	0
ISG20L2	81875	broad.mit.edu	37	1	156693162	156693162	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:156693162G>A	ENST00000313146.6	-	3	1823	c.1041C>T	c.(1039-1041)gcC>gcT	p.A347A	ISG20L2_ENST00000368219.1_Silent_p.A347A|ISG20L2_ENST00000472824.1_5'UTR	NM_030980.1	NP_112242.1	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene 20kDa-like 2	347	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGGGATTCCGGGCTAGGTGCT	0.567000													21	59					0	0	0.000229342	0	0
NUGGC	389643	broad.mit.edu	37	8	27922130	27922130	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:27922130G>A	ENST00000413272.2	-	7	972	c.830C>T	c.(829-831)cCc>cTc	p.P277L	NUGGC_ENST00000341513.6_Missense_Mutation_p.P277L	NM_001010906.1	NP_001010906.1			nuclear GTPase, germinal center associated																		GTCGGATTTGGGAAGTGTCAC	0.557000													16	33					0	0	0.000308642	0	0
SOX7	83595	broad.mit.edu	37	8	10583632	10583632	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:10583632G>A	ENST00000304501.1	-	2	861	c.783C>T	c.(781-783)gcC>gcT	p.A261A	SOX7_ENST00000553390.1_Silent_p.A313A|SOX7_ENST00000554914.1_Silent_p.A313A	NM_031439.2	NP_113627.1	Q9BT81	SOX7_HUMAN	SRY (sex determining region Y)-box 7	261					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				COAD - Colon adenocarcinoma(149;0.0732)		ACTGGCCAAGGGCCAGGGAGC	0.682000													25	43					0	0	0.000184323	0	0
CSMD2	114784	broad.mit.edu	37	1	34164364	34164364	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:34164364G>A	ENST00000373381.4	-	24	4090	c.3914C>T	c.(3913-3915)cCc>cTc	p.P1305L	CSMD2_ENST00000373380.1_Missense_Mutation_p.P178L|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1265	CUB 8.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GACACAGGTGGGCAGAGGCCG	0.602000													7	68					0	0	0.000274275	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12918976	12918976	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:12918976C>T	ENST00000240189.2	+	2	199	c.112C>T	c.(112-114)Cca>Tca	p.P38S		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	38										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCTCTATCTCCCACTCTTCAG	0.617000													11	89					0	0	0.000151284	0	0
PCLO	27445	broad.mit.edu	37	7	82763956	82763956	+	Silent	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:82763956A>C	ENST00000423517.2	-	3	3247	c.2910T>G	c.(2908-2910)ccT>ccG	p.P970P	PCLO_ENST00000333891.8_Silent_p.P970P	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	916	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GTGGCTGTGAAGGGGCAGGGG	0.512000													4	34					0	0	0.00024832	0	0
NLRP5	126206	broad.mit.edu	37	19	56515448	56515448	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:56515448G>A	ENST00000390649.3	+	2	429	c.429G>A	c.(427-429)cgG>cgA	p.R143R		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	143	DAPIN.					mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		AGAAGGCACGGGATGACATGA	0.502000													17	68					0	0	0.000295444	0	0
PCSK5	5125	broad.mit.edu	37	9	78784688	78784688	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:78784688G>A	ENST00000545128.1	+	13	2226	c.1688G>A	c.(1687-1689)aGa>aAa	p.R563K	PCSK5_ENST00000376752.4_Missense_Mutation_p.R563K|PCSK5_ENST00000376767.3_Missense_Mutation_p.R563K	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	563	Homo B/P.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TGGGGAGAAAGAGCTGCTGGT	0.423000													39	49					0	0	0.000437636	0	0
ACSM2A	123876	broad.mit.edu	37	16	20486689	20486689	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:20486689C>T	ENST00000573854.1	+	7	1014	c.900C>T	c.(898-900)ctC>ctT	p.L300L	ACSM2A_ENST00000536134.1_Silent_p.L72L|ACSM2A_ENST00000417235.2_Silent_p.L221L|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000575690.1_Silent_p.L300L|ACSM2A_ENST00000396104.2_Silent_p.L300L|ACSM2A_ENST00000219054.6_Silent_p.L300L	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	300					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						TCCAGACACTCTCCAGTTATC	0.473000													7	53					0	0	0.000274275	0	0
BCL11B	64919	broad.mit.edu	37	14	99723888	99723888	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:99723888C>T	ENST00000345514.2	-	2	613	c.347G>A	c.(346-348)gGg>gAg	p.G116E	BCL11B_ENST00000357195.3_Missense_Mutation_p.G116E|BCL11B_ENST00000443726.2_Intron	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	515						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GACTTGGATCCCGATCTCCAC	0.612000			T	TLX3	T-ALL								5	30					0	0	8.12818e-05	0	0
VSIG10	54621	broad.mit.edu	37	12	118511792	118511792	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:118511792G>A	ENST00000359236.5	-	5	1207	c.931C>T	c.(931-933)Ccc>Tcc	p.P311S		NM_019086.5	NP_061959.2	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	311	Ig-like C2-type 4.					integral to membrane				endometrium(5)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|urinary_tract(1)	17						AGAAGGGAGGGACCCCCTGGT	0.493000													17	11					0	0	0.000229342	0	0
DLL1	28514	broad.mit.edu	37	6	170592513	170592513	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:170592513C>T	ENST00000366756.3	-	9	2187	c.1854G>A	c.(1852-1854)aaG>aaA	p.K618K		NM_005618.3	NP_005609.3	O00548	DLL1_HUMAN	delta-like 1 (Drosophila)	618					cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			NS(2)|breast(1)|endometrium(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	33		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		GGAAGTCCGCCTTCTTGTTGG	0.587000													22	74					0	0	0.00047179	0	0
ZNF98	148198	broad.mit.edu	37	19	22585597	22585597	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:22585597G>A	ENST00000357774.5	-	3	368	c.247C>T	c.(247-249)Ccc>Tcc	p.P83S	ZNF98_ENST00000601553.1_Missense_Mutation_p.P83S	NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	83	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				CTACCTGGGGGTTCAGTTACC	0.403000													13	88					0	0	7.07596e-05	0	0
ZBED6CL	113763	broad.mit.edu	37	7	150027541	150027541	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:150027541G>A	ENST00000343855.4	+	1	604	c.48G>A	c.(46-48)gtG>gtA	p.V16V	LRRC61_ENST00000493307.1_Intron|LRRC61_ENST00000359623.4_Intron|LRRC61_ENST00000323078.7_Intron	NM_138434.2	NP_612443.1			ZBED6 C-terminal like																		TGAGCCAGGTGCTGCCCCAGC	0.642000													8	83					0	0	3.86212e-05	0	0
PRR23B	389151	broad.mit.edu	37	3	138739223	138739223	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:138739223C>T	ENST00000329447.5	-	1	545	c.281G>A	c.(280-282)gGa>gAa	p.G94E	MRPS22_ENST00000495075.1_Intron	NM_001013650.2	NP_001013672.1	Q6ZRT6	PR23B_HUMAN	proline rich 23B	94										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GAGGGTGTGTCCACCGAGAGA	0.662000													27	21					0	0	0.000184323	0	0
RNF152	220441	broad.mit.edu	37	18	59483638	59483638	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr18:59483638C>T	ENST00000312828.3	-	2	1158	c.59G>A	c.(58-60)aGc>aAc	p.S20N		NM_173557.2	NP_775828.1	Q8N8N0	RN152_HUMAN	ring finger protein 152	20					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)	17		Colorectal(73;0.186)				GCGCCGGGGGCTGTAGTAATT	0.597000													20	62					0	0	0.000229342	0	0
ABCA6	23460	broad.mit.edu	37	17	67080433	67080433	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:67080433C>T	ENST00000284425.2	-	34	4498	c.4324G>A	c.(4324-4326)Ggc>Agc	p.G1442S	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1442	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					GGGTCTATGCCCGTAGATGGT	0.493000													17	34					0	0	0.000422831	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23816050	23816050	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:23816050G>A	ENST00000264867.2	-	8	1175	c.1056C>T	c.(1054-1056)tcC>tcT	p.S352S	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	352					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				CATACAACTCGGATTGCTCCG	0.537000													11	85					0	0	6.40141e-05	0	0
DDX3Y	8653	broad.mit.edu	37	Y	15028247	15028247	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrY:15028247G>A	ENST00000336079.3	+	13	1490	c.1384G>A	c.(1384-1386)Gaa>Aaa	p.E462K	DDX3Y_ENST00000360160.4_Missense_Mutation_p.E462K	NM_001122665.1|NM_004660.3	NP_001116137.1|NP_004651.2	O15523	DDX3Y_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked	462	Helicase C-terminal.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|RNA binding			kidney(1)|liver(2)|lung(1)|upper_aerodigestive_tract(1)	5						CTTATACCATGAAGGATATGC	0.438000													10	17					0	0	3.86212e-05	0	0
CHEK2	11200	broad.mit.edu	37	22	29130443	29130443	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:29130443G>A	ENST00000382580.2	-	2	342	c.267C>T	c.(265-267)acC>acT	p.T89T	CHEK2_ENST00000404276.1_Silent_p.T89T|CHEK2_ENST00000405598.1_Silent_p.T89T|CHEK2_ENST00000402731.1_Silent_p.T89T|CHEK2_ENST00000403642.1_Silent_p.T89T|CHEK2_ENST00000348295.3_Silent_p.T89T|CHEK2_ENST00000328354.6_Silent_p.T89T|CHEK2_ENST00000382578.1_Silent_p.T89T|CHEK2_ENST00000382566.1_Silent_p.T89T|CHEK2_ENST00000382565.1_Silent_p.T89T|CHEK2_ENST00000544772.1_5'UTR	NM_001005735.1	NP_001005735.1	O96017	CHK2_HUMAN	checkpoint kinase 2	89					cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						AGGGGGCAGGGGTAGGCTCCT	0.493000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					16	25					0	0	0.000308642	0	0
M1AP	130951	broad.mit.edu	37	2	74834339	74834339	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:74834339C>T	ENST00000290536.5	-	4	554	c.438G>A	c.(436-438)ctG>ctA	p.L146L	M1AP_ENST00000536235.1_Silent_p.L146L|M1AP_ENST00000409585.1_Silent_p.L146L|M1AP_ENST00000358434.2_5'UTR	NM_138804.3	NP_620159.2			meiosis 1 associated protein																		GCTGAGAAGTCAGAATAGTAA	0.433000													23	54					0	0	0.000117367	0	0
RNGTT	8732	broad.mit.edu	37	6	89479524	89479524	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:89479524G>A	ENST00000369485.4	-	13	1594	c.1408C>T	c.(1408-1410)Cgt>Tgt	p.R470C	RNGTT_ENST00000265607.6_Missense_Mutation_p.R447C|RNGTT_ENST00000369475.3_Missense_Mutation_p.R470C|RNGTT_ENST00000538899.1_Missense_Mutation_p.R387C	NM_003800.3	NP_003791.3	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	470	GTase.				interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	21		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		ATTTTTAGACGAAAATCCACA	0.358000													9	19					0	0	0.000442599	0	0
ST8SIA2	8128	broad.mit.edu	37	15	93007428	93007428	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:93007428G>A	ENST00000268164.3	+	6	1178	c.941G>A	c.(940-942)gGc>gAc	p.G314D	ST8SIA2_ENST00000539113.1_Missense_Mutation_p.G293D	NM_006011.3	NP_006002.1	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	314					axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(2)|large_intestine(6)|lung(9)|skin(2)|urinary_tract(1)	20	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			TACCTCTACGGCTTCTGGCCC	0.522000													19	52					0	0	0.000229342	0	0
LILRP2	79166	broad.mit.edu	37	19	55221523	55221523	+	RNA	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:55221523C>T	ENST00000413439.1	+	0	1303																											AGGCCAACTTCACCCTGGGCC	0.642000													8	20					0	0	0.000442599	0	0
LRIG1	26018	broad.mit.edu	37	3	66431917	66431917	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:66431917C>T	ENST00000383703.3	-	18	3290	c.2687G>A	c.(2686-2688)gGg>gAg	p.G896E	SLC25A26_ENST00000536651.1_Intron|LRIG1_ENST00000273261.3_Missense_Mutation_p.G919E|LRIG1_ENST00000496559.2_5'UTR			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	919						integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		CTTATGTGGCCCAGGTGTCCC	0.507000													11	61					0	0	0.000151284	0	0
TRIM22	10346	broad.mit.edu	37	11	5730807	5730807	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:5730807C>T	ENST00000379965.3	+	8	1703	c.1426C>T	c.(1426-1428)Cga>Tga	p.R476*	TRIM5_ENST00000380027.1_Intron	NM_001199573.1|NM_006074.4	NP_001186502.1|NP_006065.2	Q8IYM9	TRI22_HUMAN	tripartite motif containing 22	476	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			kidney(3)|large_intestine(8)|lung(9)|prostate(1)|stomach(2)	23		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		TCGCTTTTCTCGACCTGCTTA	0.473000													16	140					0	0	9.7654e-05	0	0
BCAS1	8537	broad.mit.edu	37	20	52569994	52569994	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:52569994G>A	ENST00000395961.3	-	11	1823	c.1657C>T	c.(1657-1659)Ctt>Ttt	p.L553F	BCAS1_ENST00000434986.2_Missense_Mutation_p.L219F|BCAS1_ENST00000371435.2_Missense_Mutation_p.L475F|BCAS1_ENST00000371440.3_Missense_Mutation_p.L562F	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	553						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			AAGCCCCCAAGGGACTGCTGC	0.532000													14	48					0	0	7.07596e-05	0	0
HDAC9	9734	broad.mit.edu	37	7	18801862	18801862	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:18801862C>T	ENST00000406451.3	+	15	2267	c.2117C>T	c.(2116-2118)cCc>cTc	p.P706L	HDAC9_ENST00000432645.2_Missense_Mutation_p.P706L|HDAC9_ENST00000401921.1_Missense_Mutation_p.P665L|HDAC9_ENST00000441542.2_Missense_Mutation_p.P709L	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	706	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	GGCACCAACCCCCTGGACGGA	0.502000													5	5					0	0	1.23904e-05	0	0
SLC6A13	6540	broad.mit.edu	37	12	369044	369044	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:369044G>A	ENST00000343164.4	-	2	227	c.175C>T	c.(175-177)Ccc>Tcc	p.P59S	SLC6A13_ENST00000445055.2_Missense_Mutation_p.P59S|SLC6A13_ENST00000436453.1_Missense_Mutation_p.P59S	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	59					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CAGAGATAGGGAAACCTCCAG	0.562000													53	28					0	0	0.000147903	0	0
ISM2	145501	broad.mit.edu	37	14	77948741	77948741	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:77948741G>A	ENST00000393684.3	-	5	1024	c.633C>T	c.(631-633)ttC>ttT	p.F211F	ISM2_ENST00000342219.4_Silent_p.F299F|ISM2_ENST00000493585.1_Intron|ISM2_ENST00000412904.1_Silent_p.F218F|ISM2_ENST00000429906.1_Silent_p.F218F			Q6H9L7	ISM2_HUMAN	isthmin 2	299						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						TAGTTCCATTGAACCAGAGCG	0.557000													18	19					0	0	0.000229342	0	0
DPY19L2P2	349152	broad.mit.edu	37	7	102883456	102883456	+	RNA	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:102883456A>C	ENST00000312132.4	-	0	2653																											TTGAAAAAGAAGCACAGTACT	0.308000													5	40					0	0	8.12818e-05	0	0
UNC79	57578	broad.mit.edu	37	14	94160683	94160683	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:94160683G>A	ENST00000553484.1	+	49	7810	c.7656G>A	c.(7654-7656)atG>atA	p.M2552I	UNC79_ENST00000393151.2_Missense_Mutation_p.M2530I|UNC79_ENST00000555664.1_Missense_Mutation_p.M2491I|UNC79_ENST00000256339.4_Missense_Mutation_p.M2353I			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2530						integral to membrane		p.M2353I(1)|p.M2552I(1)		breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TGTTTCAGATGGTAGAAATGG	0.388000													9	21					0	0	0.000442599	0	0
ARL4D	379	broad.mit.edu	37	17	41477138	41477138	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:41477138C>T	ENST00000320033.4	+	2	245	c.38C>T	c.(37-39)tCc>tTc	p.S13F		NM_001661.3	NP_001652.2	P49703	ARL4D_HUMAN	ADP-ribosylation factor-like 4D	13					protein secretion|small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|GTPase activity|protein binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	8		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.155)		CCCACTGCCTCCTCCTTCTTG	0.562000													9	46					0	0	3.86212e-05	0	0
PRB1	5542	broad.mit.edu	37	12	11506753	11506753	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:11506753C>T	ENST00000500254.2	-	3	321	c.284G>A	c.(283-285)gGa>gAa	p.G95E	PRB1_ENST00000545626.1_Missense_Mutation_p.G95E|PRB1_ENST00000546254.1_Missense_Mutation_p.G95E	NM_005039.3|NM_199353.2	NP_005030.2|NP_955385.1	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1	278	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in allele M).			extracellular region				NS(1)|central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20			OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTGTGGTTTTCCTGGAGGAGA	0.607000													83	181					0	0	0.000147903	0	0
MPP3	4356	broad.mit.edu	37	17	41891659	41891659	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:41891659G>A	ENST00000398393.1	-	13	1415	c.1155C>T	c.(1153-1155)tcC>tcT	p.S385S	MPP3_ENST00000475450.1_5'UTR|MPP3_ENST00000398389.4_Silent_p.S360S			Q13368	MPP3_HUMAN	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	360	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		CAGCTCCGGAGGACATCTTTC	0.637000													29	56					0	0	0.000339439	0	0
DOCK3	1795	broad.mit.edu	37	3	51411906	51411906	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:51411906C>T	ENST00000266037.9	+	50	5323	c.5300C>T	c.(5299-5301)cCc>cTc	p.P1767L		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1767	Ser-rich.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		ACAGGCTCTCCCTCTCTGCCA	0.552000													4	7					0	0	0.00024832	0	0
PLOD3	8985	broad.mit.edu	37	7	100855624	100855624	+	Missense_Mutation	SNP	G	G	A	rs150001477	byFrequency	TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:100855624G>A	ENST00000223127.3	-	10	1435	c.1037C>T	c.(1036-1038)tCc>tTc	p.S346F		NM_001084.4	NP_001075.1	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	346					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	31	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	CTGCGGCCAGGAGTCAGCGAT	0.662000													13	67					0	0	0.000219431	0	0
MECOM	2122	broad.mit.edu	37	3	168861491	168861491	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:168861491C>T	ENST00000264674.3	-	3	271	c.133G>A	c.(133-135)Gat>Aat	p.D45N	MECOM_ENST00000433243.2_5'UTR|MECOM_ENST00000468789.1_5'UTR|MECOM_ENST00000472280.1_5'UTR|MECOM_ENST00000464456.1_5'UTR|MECOM_ENST00000494292.1_Missense_Mutation_p.D169N|MECOM_ENST00000392736.3_5'UTR	NM_001105077.3	NP_001098547.3	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						CATACCTGATCATTTATCTGG	0.413000													26	49					0	0	0.000117367	0	0
SAG	6295	broad.mit.edu	37	2	234255480	234255480	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:234255480G>A	ENST00000409110.1	+	16	1370	c.1140G>A	c.(1138-1140)gaG>gaA	p.E380E		NM_000541.4	NP_000532.2	P10523	ARRS_HUMAN	S-antigen; retina and pineal gland (arrestin)	380					rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway		protein phosphatase inhibitor activity			cervix(1)|kidney(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	9		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.018)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.054)		Epithelial(121;2.86e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00608)|Lung(119;0.00714)|GBM - Glioblastoma multiforme(43;0.207)		TAGTTTTTGAGGAGTTTGCTC	0.418000													6	29					0	0	8.12818e-05	0	0
ANO4	121601	broad.mit.edu	37	12	101480503	101480503	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:101480503C>T	ENST00000392979.3	+	16	1858	c.1497C>T	c.(1495-1497)ttC>ttT	p.F499F	ANO4_ENST00000392977.3_Silent_p.F534F|ANO4_ENST00000299222.9_Silent_p.F54F|ANO4_ENST00000550015.1_Silent_p.F54F	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	534						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TCAGCACTTTCGCTGCCTTTA	0.507000										HNSCC(74;0.22)			14	54					0	0	7.07596e-05	0	0
SLFN11	91607	broad.mit.edu	37	17	33680866	33680866	+	Missense_Mutation	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:33680866T>A	ENST00000394566.1	-	6	1683	c.1411A>T	c.(1411-1413)Att>Ttt	p.I471F	SLFN11_ENST00000308377.4_Missense_Mutation_p.I471F	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	471						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GTGTAGAGAATGGGGGTGCTG	0.512000													6	14					0	0	8.12818e-05	0	0
DCX	1641	broad.mit.edu	37	X	110653511	110653511	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:110653511C>T	ENST00000338081.3	-	2	530	c.359G>A	c.(358-360)cGa>cAa	p.R120Q	DCX_ENST00000356220.3_Missense_Mutation_p.R39Q|DCX_ENST00000488120.1_Missense_Mutation_p.R39Q|DCX_ENST00000356915.2_Missense_Mutation_p.R39Q|DCX_ENST00000496551.1_5'UTR|DCX_ENST00000371993.2_Missense_Mutation_p.R39Q	NM_000555.3	NP_000546.2	O43602	DCX_HUMAN	doublecortin	120					axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|skin(6)|upper_aerodigestive_tract(1)	41						GGTTCTGGTTCGGTAGAAGCT	0.527000													12	10					0	0	0.00010058	0	0
SLC44A5	204962	broad.mit.edu	37	1	75684344	75684344	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:75684344G>A	ENST00000370855.5	-	17	1473	c.1360C>T	c.(1360-1362)Cct>Tct	p.P454S	SLC44A5_ENST00000535611.1_Missense_Mutation_p.P324S|SLC44A5_ENST00000370859.3_Missense_Mutation_p.P454S	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	454						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						TGGAAGGTAGGGATGTACTGA	0.413000													6	42					0	0	3.59834e-05	0	0
TFAP4	7023	broad.mit.edu	37	16	4311931	4311931	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:4311931G>A	ENST00000204517.6	-	4	702	c.374C>T	c.(373-375)cCc>cTc	p.P125L		NM_003223.2	NP_003214.1	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer binding protein 4)	125					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|endometrium(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						CCGTCGCTTGGGGGACGAGCC	0.657000											OREG0023575	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	8					0	0	1.23904e-05	0	0
PDE2A	5138	broad.mit.edu	37	11	72289356	72289356	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:72289356C>T	ENST00000334456.5	-	30	2781	c.2536G>A	c.(2536-2538)Gag>Aag	p.E846K	PDE2A_ENST00000376450.3_Missense_Mutation_p.E590K|PDE2A_ENST00000540345.1_Missense_Mutation_p.E837K|PDE2A_ENST00000444035.2_Missense_Mutation_p.E837K|PDE2A_ENST00000418754.2_Missense_Mutation_p.E731K|PDE2A_ENST00000544570.1_Missense_Mutation_p.E839K	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	846	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	TCCATCATCTCCATCGGCCTG	0.562000													51	210					0	0	0.000147903	0	0
RAD21	5885	broad.mit.edu	37	8	117862909	117862909	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:117862909G>T	ENST00000297338.2	-	12	1855	c.1568C>A	c.(1567-1569)cCa>cAa	p.P523Q	RAD21_ENST00000518055.1_Missense_Mutation_p.P68Q|RAD21_ENST00000523986.1_Missense_Mutation_p.P27Q	NM_006265.2	NP_006256.1	O60216	RAD21_HUMAN	RAD21 homolog (S. pombe)	523					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|stomach(1)	32	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					ctctttttcTGGCAGAAGTTC	0.398000													6	68					3.59834e-05	0.000746526	3.59834e-05	1	0
COPB2	9276	broad.mit.edu	37	3	139094319	139094319	+	Missense_Mutation	SNP	C	C	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:139094319C>G	ENST00000333188.5	-	6	823	c.642G>C	c.(640-642)tgG>tgC	p.W214C	COPB2_ENST00000507777.1_Missense_Mutation_p.W185C	NM_004766.2	NP_004757.1	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta prime)	214					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	24						CCTGATAATCCCATATTTTAA	0.378000													6	78					0	0	3.59834e-05	0	0
CRHR2	1395	broad.mit.edu	37	7	30695256	30695256	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:30695256C>T	ENST00000471646.1	-	10	1410	c.993G>A	c.(991-993)ggG>ggA	p.G331G	CRHR2_ENST00000341843.4_Silent_p.G317G|CRHR2_ENST00000348438.4_Silent_p.G358G|CRHR2_ENST00000506074.2_Silent_p.G331G	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	331					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GGTCGTCCTCCCCGGGATTGA	0.592000													17	122					0	0	7.07596e-05	0	0
VWA8	23078	broad.mit.edu	37	13	42273273	42273273	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr13:42273273G>A	ENST00000379310.3	-	29	3566	c.3498C>T	c.(3496-3498)caC>caT	p.H1166H		NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		TCACAAAAGGGTGCCAAACGC	0.473000													7	48					0	0	8.12818e-05	0	0
SUCO	51430	broad.mit.edu	37	1	172538211	172538211	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:172538211C>T	ENST00000367723.3	+	7	1386	c.1262C>T	c.(1261-1263)cCc>cTc	p.P421L	SUCO_ENST00000263688.3_Missense_Mutation_p.P262L	NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		GTAGCAAGTCCCAAAGATCCA	0.323000													31	80					0	0	0.000409698	0	0
MOGAT2	80168	broad.mit.edu	37	11	75431212	75431212	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:75431212C>T	ENST00000526712.1	+	1	794	c.21C>T	c.(19-21)atC>atT	p.I7I	MOGAT2_ENST00000198801.5_Silent_p.I89I			Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	89					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					ATTTCCCCATCTCGGTGAGTA	0.592000													30	79					0	0	0.000279167	0	0
ABCC8	6833	broad.mit.edu	37	11	17464857	17464857	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:17464857G>A	ENST00000302539.4	-	9	1460	c.1335C>T	c.(1333-1335)atC>atT	p.I445I	ABCC8_ENST00000389817.3_Silent_p.I445I	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	445	ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CACCCACAATGATCTGAGGAA	0.537000													38	114					0	0	0.000374591	0	0
BTC	685	broad.mit.edu	37	4	75673320	75673320	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:75673320T>G	ENST00000395743.3	-	5	828	c.468A>C	c.(466-468)gaA>gaC	p.E156D		NM_001729.2	NP_001720.1	P35070	BTC_HUMAN	betacellulin	156					positive regulation of cell division|positive regulation of cell proliferation	extracellular space|integral to membrane|plasma membrane|soluble fraction	epidermal growth factor receptor binding|growth factor activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	10			Lung(101;0.219)			TTTCCATTTCTTCTTCTTTCT	0.343000													7	74					0	0	0.000274275	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841458	8841458	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:8841458C>T	ENST00000324060.2	+	1	143	c.68C>T	c.(67-69)tCa>tTa	p.S23L		NM_001004699.1	NP_001004699.1	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z, member 1	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CACTCAGGATCACGCCAGCTC	0.527000													8	42					0	0	0.000274275	0	0
TKTL1	8277	broad.mit.edu	37	X	153555960	153555960	+	Missense_Mutation	SNP	C	C	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:153555960C>G	ENST00000369915.3	+	11	1614	c.1425C>G	c.(1423-1425)gaC>gaG	p.D475E	TKTL1_ENST00000217905.7_Missense_Mutation_p.D215E|TKTL1_ENST00000369912.2_Missense_Mutation_p.D419E|TKTL1_ENST00000482044.1_3'UTR	NM_001145933.1|NM_012253.3	NP_001139405.1|NP_036385.3	P51854	TKTL1_HUMAN	transketolase-like 1	475					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			NS(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(5)|prostate(1)|skin(1)|urinary_tract(2)	34	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GTGTCAGTGACAAGGTCACAG	0.463000													21	60					0	0	0.000295444	0	0
PRR5L	79899	broad.mit.edu	37	11	36453412	36453412	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:36453412C>T	ENST00000378867.3	+	6	659	c.304C>T	c.(304-306)Ctt>Ttt	p.L102F	PRR5L_ENST00000527487.1_Missense_Mutation_p.L102F|PRR5L_ENST00000530639.1_Missense_Mutation_p.L102F|PRR5L_ENST00000389693.3_3'UTR|PRR5L_ENST00000311599.5_Missense_Mutation_p.L76F	NM_024841.4	NP_079117.3	Q6MZQ0	PRR5L_HUMAN	proline rich 5 like	102										breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(7)|ovary(1)	19						GAACCAGCTTCTTGCAAAAGG	0.483000													8	74					0	0	3.86212e-05	0	0
MYO16	23026	broad.mit.edu	37	13	109475492	109475492	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr13:109475492T>G	ENST00000356711.2	+	9	1023	c.897T>G	c.(895-897)ttT>ttG	p.F299L	MYO16_ENST00000357550.2_Missense_Mutation_p.F299L|MYO16_ENST00000251041.5_Missense_Mutation_p.F299L	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	299					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCTCTGAGTTTATTGAGGAAA	0.358000													7	32					0	0	0.000157383	0	0
LEPR	3953	broad.mit.edu	37	1	66083825	66083825	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:66083825C>T	ENST00000349533.6	+	16	2576	c.2391C>T	c.(2389-2391)atC>atT	p.I797I	LEPR_ENST00000344610.8_Silent_p.I797I|LEPR_ENST00000371058.1_Silent_p.I797I|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371059.3_Silent_p.I797I|LEPR_ENST00000371060.3_Silent_p.I797I	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	797	Fibronectin type-III 4.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		AGTATTATATCCATGGTAAGT	0.264000													24	68					0	0	7.16444e-05	0	0
MUC16	94025	broad.mit.edu	37	19	9046505	9046505	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:9046505G>A	ENST00000397910.4	-	5	35329	c.35126C>T	c.(35125-35127)tCc>tTc	p.S11709F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11711	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACTACTATGGGAAAAACTGGA	0.512000													14	93					0	0	9.7654e-05	0	0
SLFN11	91607	broad.mit.edu	37	17	33680868	33680868	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:33680868G>A	ENST00000394566.1	-	6	1681	c.1409C>T	c.(1408-1410)cCc>cTc	p.P470L	SLFN11_ENST00000308377.4_Missense_Mutation_p.P470L	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	470						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GTAGAGAATGGGGGTGCTGTT	0.522000													6	14					0	0	8.12818e-05	0	0
TRIOBP	11078	broad.mit.edu	37	22	38151143	38151143	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:38151143C>T	ENST00000406386.3	+	14	5778	c.5523C>T	c.(5521-5523)tcC>tcT	p.S1841S	TRIOBP_ENST00000403663.2_Silent_p.S128S|RP1-37E16.12_ENST00000455236.1_RNA|TRIOBP_ENST00000407319.2_Silent_p.S128S	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1841	PH.				actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					ACCTGCGTTCCTGCACGGATG	0.627000													6	9					0	0	0.000442599	0	0
PRDM16	63976	broad.mit.edu	37	1	3334463	3334463	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:3334463C>T	ENST00000378398.3	+	12	2845	c.2763C>T	c.(2761-2763)tcC>tcT	p.S921S	PRDM16_ENST00000378391.2_Silent_p.S921S|PRDM16_ENST00000514189.1_Silent_p.S921S|PRDM16_ENST00000511072.1_Silent_p.S922S|PRDM16_ENST00000442529.2_Silent_p.S920S|PRDM16_ENST00000441472.2_Silent_p.S920S|PRDM16_ENST00000270722.5_Silent_p.S921S|PRDM16_ENST00000512462.1_3'UTR			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	921	Interaction with CTBP1 and CTBP2 (By similarity).|Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CGGGCAGCTCCCTGCAGCCCC	0.602000			T	EVI1	"""MDS, AML"""								14	58					0	0	0.000308642	0	0
PARK2	5071	broad.mit.edu	37	6	162394449	162394449	+	Splice_Site	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:162394449C>T	ENST00000366898.1	-	6	721	c.618_splice	c.e6-1	p.E207_splice	PARK2_ENST00000338468.3_Splice_Site_p.E16_splice|PARK2_ENST00000366894.1_Splice_Site_p.E16_splice|PARK2_ENST00000366896.1_Splice_Site_p.E58_splice|PARK2_ENST00000366897.1_Splice_Site_p.E179_splice|PARK2_ENST00000366892.1_Splice_Site_p.E207_splice	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	207	SYT11 binding 1.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		AAGAAAAATTCCTGAAAGAAA	0.398000													13	39					0	0	0.00010058	0	0
EDN3	1908	broad.mit.edu	37	20	57876671	57876671	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:57876671G>A	ENST00000311585.7	+	2	629	c.259G>A	c.(259-261)Ggg>Agg	p.G87R	EDN3_ENST00000371028.2_Missense_Mutation_p.G87R|EDN3_ENST00000337938.2_Missense_Mutation_p.G87R|EDN3_ENST00000395654.3_Missense_Mutation_p.G87R|EDN3_ENST00000371025.3_Missense_Mutation_p.G87R	NM_207032.1	NP_996915.1	P14138	EDN3_HUMAN	endothelin 3	87					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	19	all_lung(29;0.0115)					GGCGGCCGAGGGGGCCCCTGA	0.642000													39	44					0	0	0.000270559	0	0
RNFT2	84900	broad.mit.edu	37	12	117271725	117271725	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:117271725C>T	ENST00000257575.4	+	8	1244	c.1011C>T	c.(1009-1011)atC>atT	p.I337I	RNFT2_ENST00000407967.3_Silent_p.I337I|RNFT2_ENST00000392549.2_Silent_p.I337I|RNFT2_ENST00000319176.7_Intron			Q96EX2	RNFT2_HUMAN	ring finger protein, transmembrane 2	337						integral to membrane	zinc ion binding	p.I337I(1)|p.I247I(1)		endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.034)		GGGTCCTGATCGTTCTCTACA	0.607000													8	11					0	0	0.000274275	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664240	22664240	+	RNA	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:22664240T>G	ENST00000426066.1	+	0	763					NR_027293.1																						GATAAGCTGCTGATGAGCGGT	0.532000													5	39					0	0	3.59834e-05	0	0
TENM2	57451	broad.mit.edu	37	5	167687367	167687367	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:167687367C>T	ENST00000519204.1	+	27	7267	c.7149C>T	c.(7147-7149)ttC>ttT	p.F2383F	TENM2_ENST00000520394.1_Silent_p.F2265F|TENM2_ENST00000545108.1_Silent_p.F2503F|TENM2_ENST00000403607.2_Silent_p.F2328F|TENM2_ENST00000518659.1_Silent_p.F2504F					teneurin transmembrane protein 2																		AAATGTATTTCGTGCCTCCTC	0.428000													37	90					0	0	0.000191422	0	0
FADS2	9415	broad.mit.edu	37	11	61615704	61615704	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:61615704C>T	ENST00000278840.4	+	5	1322	c.692C>T	c.(691-693)cCc>cTc	p.P231L	FADS2_ENST00000522056.1_Missense_Mutation_p.P200L|FADS2_ENST00000521849.1_Missense_Mutation_p.P231L|FADS2_ENST00000257261.6_Missense_Mutation_p.P209L	NM_004265.2	NP_004256.1	O95864	FADS2_HUMAN	fatty acid desaturase 2	231					electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			breast(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20					Alpha-Linolenic Acid(DB00132)	CACAAGGATCCCGATGTGAAC	0.567000													19	86					0	0	0.000175454	0	0
NGDN	25983	broad.mit.edu	37	14	23946554	23946554	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:23946554C>T	ENST00000397154.3	+	9	872	c.859C>T	c.(859-861)Cat>Tat	p.H287Y	NGDN_ENST00000408901.3_Missense_Mutation_p.H287Y|NGDN_ENST00000556580.1_Missense_Mutation_p.H43Y			Q8NEJ9	NGDN_HUMAN	neuroguidin, EIF4E binding protein	287					regulation of translation	axon|cytoplasm|dendrite|filopodium|nucleus				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	12	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		GGGAACTGTTCATCTTGATGA	0.448000													47	98					0	0	0.000147903	0	0
FAM151B	167555	broad.mit.edu	37	5	79817891	79817891	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:79817891C>T	ENST00000282226.4	+	5	760	c.605C>T	c.(604-606)cCt>cTt	p.P202L	FAM151B_ENST00000511718.1_3'UTR	NM_205548.2	NP_991111.2	Q6UXP7	F151B_HUMAN	family with sequence similarity 151, member B	202										breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)	7		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;8.21e-47)|Epithelial(54;8.3e-42)|all cancers(79;1.97e-36)		GTAACGTTCCCTGTCAGAGCA	0.343000													34	72					0	0	0.000132358	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144874691	144874691	+	Silent	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:144874691G>T	ENST00000369359.4	-	33	5363	c.5325C>A	c.(5323-5325)ccC>ccA	p.P1775P	PDE4DIP_ENST00000369356.4_Silent_p.P1639P|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000530740.1_Silent_p.P1775P|PDE4DIP_ENST00000369354.3_Silent_p.P1639P|PDE4DIP_ENST00000313382.9_Silent_p.P1595P			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1639					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding	p.P1639P(2)		NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTGAGTGACTGGGAGAAGCTT	0.502000			T	PDGFRB	MPD								13	277					1.15088e-07	2.39746e-06	0.000422831	1	0
ANAPC10	10393	broad.mit.edu	37	4	146017176	146017176	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:146017176C>A	ENST00000507656.1	-	2	169	c.76G>T	c.(76-78)Ggg>Tgg	p.G26W	ANAPC10_ENST00000309439.5_Missense_Mutation_p.G26W|ANAPC10_ENST00000451299.2_Missense_Mutation_p.G26W|ANAPC10_ENST00000510270.1_5'UTR|ANAPC10_ENST00000512680.1_Missense_Mutation_p.G26W	NM_001256706.1	NP_001243635.1	Q9UM13	APC10_HUMAN	anaphase promoting complex subunit 10	26	DOC.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin-protein ligase activity			endometrium(1)|large_intestine(3)|lung(1)|skin(1)	6	all_hematologic(180;0.151)					GCTTGTGACCCAATTTCCCGT	0.413000													11	265					0.000308642	0.00636417	0.000308642	1	0
RGS7	6000	broad.mit.edu	37	1	240978044	240978044	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:240978044G>A	ENST00000366565.1	-	12	1198	c.817C>T	c.(817-819)Cgg>Tgg	p.R273W	RGS7_ENST00000446183.2_Missense_Mutation_p.R189W|RGS7_ENST00000331110.7_Missense_Mutation_p.R247W|RGS7_ENST00000366564.1_Missense_Mutation_p.R273W|RGS7_ENST00000348120.2_Missense_Mutation_p.R220W|RGS7_ENST00000366563.1_Missense_Mutation_p.R273W|RGS7_ENST00000401882.1_Missense_Mutation_p.R220W|RGS7_ENST00000407727.1_Missense_Mutation_p.R273W|RGS7_ENST00000366562.4_Missense_Mutation_p.R273W	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	273	G protein gamma.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity	p.R273W(2)		breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			ATTTTTAACCGATGTCTATCT	0.289000													17	95					0	0	0.000229342	0	0
TDGF1P3	6998	broad.mit.edu	37	X	109764350	109764350	+	RNA	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:109764350T>A	ENST00000602699.1	+	0	811					NR_002718.2																						CCCTAATTGTTAAAAGCTATG	0.433000													11	36					0	0	0.000219431	0	0
AKAP13	11214	broad.mit.edu	37	15	86124251	86124251	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:86124251G>A	ENST00000394518.2	+	7	3047	c.2952G>A	c.(2950-2952)ccG>ccA	p.P984P	AKAP13_ENST00000361243.2_Silent_p.P984P	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	984					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GTAATTCACCGGGTGCATCCT	0.488000													11	115					0	0	6.40141e-05	0	0
ITPR1	3708	broad.mit.edu	37	3	4716865	4716865	+	Missense_Mutation	SNP	C	C	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:4716865C>G	ENST00000354582.6	+	23	3062	c.2712C>G	c.(2710-2712)atC>atG	p.I904M	ITPR1_ENST00000456211.2_Missense_Mutation_p.I889M|ITPR1_ENST00000423119.2_Missense_Mutation_p.I904M|ITPR1_ENST00000357086.4_Missense_Mutation_p.I904M|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000443694.2_Missense_Mutation_p.I889M|ITPR1_ENST00000302640.8_Missense_Mutation_p.I889M			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	904					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TGACAACAATCTTCCCCATTA	0.418000													11	101					0	0	0.00010058	0	0
CDH9	1007	broad.mit.edu	37	5	26916004	26916004	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:26916004C>A	ENST00000231021.4	-	3	429	c.257G>T	c.(256-258)gGa>gTa	p.G86V		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	86	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TTTTAAATTTCCATCTCCTTT	0.338000													12	65					1.52009e-12	3.19945e-11	0.000308642	1	0
TRIOBP	11078	broad.mit.edu	37	22	38121815	38121815	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:38121815C>T	ENST00000406386.3	+	7	3507	c.3252C>T	c.(3250-3252)ccC>ccT	p.P1084P	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1084					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AATTTGACCCCTTCCCCTTCC	0.632000													8	35					0	0	0.000151284	0	0
CSMD2	114784	broad.mit.edu	37	1	34164363	34164363	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:34164363G>A	ENST00000373381.4	-	24	4091	c.3915C>T	c.(3913-3915)ccC>ccT	p.P1305P	CSMD2_ENST00000373380.1_Silent_p.P178P|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1265	CUB 8.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CGACACAGGTGGGCAGAGGCC	0.607000													7	68					0	0	0.000274275	0	0
PAF1	54623	broad.mit.edu	37	19	39879984	39879984	+	Missense_Mutation	SNP	C	C	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:39879984C>G	ENST00000221265.3	-	6	729	c.399G>C	c.(397-399)aaG>aaC	p.K133N	PAF1_ENST00000595564.1_Missense_Mutation_p.K123N|PAF1_ENST00000221266.7_Missense_Mutation_p.K123N	NM_019088.3	NP_061961.2	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	133					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|urinary_tract(2)	17	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			TGTACTCTGTCTTTCGCATCC	0.532000													6	87					0	0	0.000274275	0	0
GRAMD3	65983	broad.mit.edu	37	5	125816369	125816369	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:125816369C>T	ENST00000285689.3	+	8	1166	c.705C>T	c.(703-705)ttC>ttT	p.F235F	RP11-517I3.1_ENST00000515808.1_RNA|GRAMD3_ENST00000511134.1_Silent_p.F219F|GRAMD3_ENST00000515200.1_Silent_p.F212F|RP11-517I3.1_ENST00000512500.1_RNA|GRAMD3_ENST00000513040.1_Silent_p.F250F|GRAMD3_ENST00000502348.1_Silent_p.F126F|GRAMD3_ENST00000542322.1_Silent_p.F243F|GRAMD3_ENST00000544396.1_Silent_p.F131F|GRAMD3_ENST00000543198.1_Silent_p.F212F	NM_023927.2	NP_076416.2	Q96HH9	GRAM3_HUMAN	GRAM domain containing 3	235										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0401)|OV - Ovarian serous cystadenocarcinoma(64;0.0604)|all cancers(49;0.108)		AAAACAGTTTCCGAGCAGACC	0.398000													11	69					0	0	0.000151284	0	0
TTC37	9652	broad.mit.edu	37	5	94863796	94863796	+	Missense_Mutation	SNP	C	C	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:94863796C>G	ENST00000358746.2	-	13	1353	c.1055G>C	c.(1054-1056)tGt>tCt	p.C352S		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	352							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						CAAATGAAGACAAAGATTCCT	0.383000													13	36					0	0	0.000219431	0	0
FAT4	79633	broad.mit.edu	37	4	126402830	126402830	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:126402830G>A	ENST00000394329.3	+	15	12766	c.12753G>A	c.(12751-12753)agG>agA	p.R4251R	FAT4_ENST00000335110.5_Silent_p.R2492R	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4251	Laminin G-like 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TAAAATTTAGGACCAGAAGCG	0.403000													13	40					0	0	0.000151284	0	0
HEATR1	55127	broad.mit.edu	37	1	236739525	236739525	+	Missense_Mutation	SNP	G	G	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:236739525G>C	ENST00000366582.3	-	22	3192	c.3078C>G	c.(3076-3078)aaC>aaG	p.N1026K	HEATR1_ENST00000366581.2_Missense_Mutation_p.N1026K	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	1026					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ATACCTCACCGTTGACTCCCT	0.363000													31	102					0	0	0.000409698	0	0
VN1R4	317703	broad.mit.edu	37	19	53770583	53770583	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:53770583C>T	ENST00000311170.4	-	1	389	c.336G>A	c.(334-336)agG>agA	p.R112R		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	112					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity	p.R112R(1)		central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		ACCTGGATTTCCTGGAGCTGA	0.498000										HNSCC(26;0.072)			4	27					0	0	3.59834e-05	0	0
AWAT1	158833	broad.mit.edu	37	X	69459652	69459652	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:69459652G>A	ENST00000374521.3	+	6	741	c.700G>A	c.(700-702)Gat>Aat	p.D234N		NM_001013579.2	NP_001013597.1	Q58HT5	AWAT1_HUMAN	acyl-CoA wax alcohol acyltransferase 1	234					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(3)|ovary(4)|skin(1)	15						GTTCCATAAGGATAGCAGGAT	0.463000													12	40					0	0	0.000308642	0	0
GSDMA	284110	broad.mit.edu	37	17	38133095	38133095	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:38133095C>T	ENST00000301659.4	+	12	1240	c.1122C>T	c.(1120-1122)ttC>ttT	p.F374F		NM_178171.4	NP_835465.2	Q96QA5	GSDMA_HUMAN	gasdermin A	374					apoptosis|induction of apoptosis	perinuclear region of cytoplasm				NS(1)|endometrium(2)|large_intestine(3)|lung(1)	7						AACAGAACTTCCTGCTGGATA	0.522000													19	73					0	0	0.000132079	0	0
NLRP3	114548	broad.mit.edu	37	1	247588789	247588789	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:247588789G>A	ENST00000366497.2	+	4	2824	c.2044G>A	c.(2044-2046)Ggg>Agg	p.G682R	NLRP3_ENST00000348069.2_Missense_Mutation_p.G682R|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000391828.3_Missense_Mutation_p.G682R|NLRP3_ENST00000366496.2_Missense_Mutation_p.G682R|NLRP3_ENST00000336119.3_Missense_Mutation_p.G682R|NLRP3_ENST00000391827.2_Missense_Mutation_p.G682R	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	682					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			ACTGTCCCTGGGGTTTCTCCA	0.507000													8	39					0	0	0.000442599	0	0
OR13F1	138805	broad.mit.edu	37	9	107267237	107267237	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:107267237G>A	ENST00000334726.2	+	1	783	c.694G>A	c.(694-696)Gaa>Aaa	p.E232K		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						CAGCTCAGTGGAAGGTCGAAG	0.493000													30	92					0	0	8.91981e-05	0	0
SETBP1	26040	broad.mit.edu	37	18	42643219	42643219	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr18:42643219C>T	ENST00000282030.5	+	6	4643	c.4347C>T	c.(4345-4347)ttC>ttT	p.F1449F		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	1449						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GCAACAACTTCGTGAAGAAGA	0.547000									Schinzel-Giedion syndrome				6	9					0	0	3.59834e-05	0	0
ITGB5	3693	broad.mit.edu	37	3	124567289	124567289	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:124567289G>A	ENST00000296181.4	-	4	774	c.478C>T	c.(478-480)Ctg>Ttg	p.L160L	ITGB5_ENST00000488466.1_5'UTR	NM_002213.3	NP_002204.2	P18084	ITB5_HUMAN	integrin, beta 5	160	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	30				GBM - Glioblastoma multiforme(114;0.163)		TTGGTGCCCAGGCTCCGGATA	0.532000													23	76					0	0	0.00047179	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716751	13716751	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:13716751C>T	ENST00000279593.3	-	13	3630	c.3421G>A	c.(3421-3423)Gag>Aag	p.E1141K		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1141					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGTGAGTTCTCCTTTGTTCGG	0.612000													13	8					0	0	0.000308642	0	0
SLC16A2	6567	broad.mit.edu	37	X	73749050	73749050	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:73749050C>T	ENST00000276033.5	+	5	1561	c.1395C>T	c.(1393-1395)gtC>gtT	p.V465V	SLC16A2_ENST00000587091.1_Silent_p.V391V			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	391						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	TTCTCCAGGTCCTTTCCTTCC	0.527000													5	5					0	0	1.23904e-05	0	0
SGSM1	129049	broad.mit.edu	37	22	25264821	25264821	+	Splice_Site	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:25264821C>T	ENST00000400358.4	+	12	1347	c.1291_splice	c.e12+1	p.F430_splice	SGSM1_ENST00000400359.4_Splice_Site_p.F430_splice	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	430						Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						AGTCGGAATTCGGTGAGCTGC	0.532000													25	65					0	0	0.000184323	0	0
KANK4	163782	broad.mit.edu	37	1	62739653	62739653	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:62739653C>T	ENST00000371153.4	-	3	1501	c.1123G>A	c.(1123-1125)Gag>Aag	p.E375K	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	375										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						TTGATTTCCTCTTCCTGCTGC	0.537000													20	80					0	0	0.000175454	0	0
TAGAP	117289	broad.mit.edu	37	6	159458043	159458043	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:159458043T>C	ENST00000367066.3	-	10	1343	c.1012A>G	c.(1012-1014)Aca>Gca	p.T338A	RP1-111C20.4_ENST00000606466.1_RNA|TAGAP_ENST00000326965.6_Missense_Mutation_p.T160A|RP1-111C20.4_ENST00000606470.1_RNA|RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000607391.1_RNA	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	338					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CCAGCAGCTGTGGCCATGGGC	0.627000													10	62					0	0	0.00010058	0	0
SLC6A19	340024	broad.mit.edu	37	5	1213673	1213673	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:1213673C>T	ENST00000304460.10	+	5	815	c.759C>T	c.(757-759)ttC>ttT	p.F253F		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	253					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity	p.F253L(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCATCGTCTTCCTCTTCACGC	0.652000													7	24					0	0	0.000442599	0	0
TPTE	7179	broad.mit.edu	37	21	10908889	10908889	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr21:10908889G>A	ENST00000298232.7	-	22	1769	c.1402C>T	c.(1402-1404)Cct>Tct	p.P468S	TPTE_ENST00000361285.4_Missense_Mutation_p.P486S|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.P448S	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	486	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAGTATGTAGGAAGATTCTAA	0.264000													6	48					0	0	0.000274275	0	0
YTHDC1	91746	broad.mit.edu	37	4	69188590	69188590	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:69188590G>A	ENST00000344157.4	-	11	1813	c.1478C>T	c.(1477-1479)cCc>cTc	p.P493L	YTHDC1_ENST00000355665.3_Missense_Mutation_p.P475L|YTHDC1_ENST00000579690.1_Missense_Mutation_p.P493L	NM_001031732.2	NP_001026902.1	Q96MU7	YTDC1_HUMAN	YTH domain containing 1	493										NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	30						TTCATCGGGGGGAAACAGAAG	0.423000													10	56					0	0	0.000151284	0	0
TSSK1B	83942	broad.mit.edu	37	5	112769888	112769888	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:112769888C>T	ENST00000390666.3	-	1	840	c.649G>A	c.(649-651)Gac>Aac	p.D217N	MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000383058.4_RNA|CTD-2201G3.1_ENST00000416046.2_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	217	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		TTGGAGTCGTCGTAGGGCATG	0.577000													12	40					0	0	0.000151284	0	0
CPN2	1370	broad.mit.edu	37	3	194061932	194061932	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:194061932G>A	ENST00000323830.3	-	2	1589	c.1500C>T	c.(1498-1500)cgC>cgT	p.R500R	CPN2_ENST00000429275.1_Silent_p.R500R	NM_001080513.2	NP_001073982.2	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	500					protein stabilization	extracellular region	enzyme regulator activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(5)|prostate(1)	27	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		CGTTCAGCCAGCGACACTGGG	0.652000													9	11					0	0	0.000274275	0	0
DSCAML1	57453	broad.mit.edu	37	11	117342587	117342587	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:117342587C>T	ENST00000321322.6	-	15	3131	c.3130G>A	c.(3130-3132)Gcc>Acc	p.A1044T	DSCAML1_ENST00000527706.1_Missense_Mutation_p.A774T	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	984	Fibronectin type-III 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TGCTCACCGGCCTCCTCAGTG	0.587000													14	79					0	0	9.7654e-05	0	0
DENND2C	163259	broad.mit.edu	37	1	115168587	115168587	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:115168587G>A	ENST00000393274.1	-	4	644	c.19C>T	c.(19-21)Cgt>Tgt	p.R7C	DENND2C_ENST00000393276.3_Missense_Mutation_p.R7C|DENND2C_ENST00000393277.1_Missense_Mutation_p.R7C	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	7										NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACAGTAGTACGAGAAAAACCA	0.358000													15	56					0	0	7.07596e-05	0	0
KRT2	3849	broad.mit.edu	37	12	53040562	53040562	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:53040562G>A	ENST00000309680.3	-	7	1452	c.1431C>T	c.(1429-1431)atC>atT	p.I477I		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	477	Coil 2.|Rod.		I -> N (in IBS).		keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		GGTAGGTGGCGATCTCCACAT	0.637000													31	50					0	0	0.000228196	0	0
MUC16	94025	broad.mit.edu	37	19	9085397	9085397	+	Missense_Mutation	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:9085397T>A	ENST00000397910.4	-	1	6621	c.6418A>T	c.(6418-6420)Atc>Ttc	p.I2140F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2140	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCAGAGCTGATACTTGCCCCC	0.502000													5	50					0	0	1.23904e-05	0	0
MLLT4	4301	broad.mit.edu	37	6	168297634	168297634	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:168297634G>A	ENST00000366806.2	+	10	1441	c.1299G>A	c.(1297-1299)ttG>ttA	p.L433L	MLLT4_ENST00000344191.4_Silent_p.L433L|MLLT4_ENST00000447894.2_Silent_p.L433L|MLLT4_ENST00000400822.3_Silent_p.L432L|MLLT4_ENST00000392112.1_Silent_p.L417L|MLLT4_ENST00000392108.3_Silent_p.L433L|MLLT4_ENST00000351017.4_Silent_p.L433L			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	433	FHA.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CAGAAAAGTTGGATGACAACT	0.458000			T	MLL	AL								5	39					0	0	1.23904e-05	0	0
SRGAP2	23380	broad.mit.edu	37	1	206619523	206619523	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:206619523C>T	ENST00000414007.1	+	14	1557	c.1557C>T	c.(1555-1557)tcC>tcT	p.S519S	SRGAP2_ENST00000471256.1_3'UTR|SRGAP2_ENST00000419187.2_5'UTR			O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	659	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(1)|breast(1)|kidney(1)|lung(1)	4	Breast(84;0.137)					ACCAGGTGTCCTGCCAAGCCC	0.557000													12	41					0	0	0.000151284	0	0
MYOZ2	51778	broad.mit.edu	37	4	120107233	120107233	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:120107233C>T	ENST00000307128.5	+	6	886	c.673C>T	c.(673-675)Ccc>Tcc	p.P225S		NM_016599.4	NP_057683.1	Q9NPC6	MYOZ2_HUMAN	myozenin 2	225							protein phosphatase 2B binding			endometrium(1)|large_intestine(6)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						CTTTGTCAATCCCCTTTCTGG	0.383000													18	58					0	0	9.7654e-05	0	0
ZNF618	114991	broad.mit.edu	37	9	116812003	116812003	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:116812003C>T	ENST00000288466.7	+	14	2241	c.2142C>T	c.(2140-2142)atC>atT	p.I714I	ZNF618_ENST00000374126.5_Silent_p.I807I|ZNF618_ENST00000470105.1_3'UTR	NM_133374.2	NP_588615.2	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	807					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|lung(10)|urinary_tract(1)	16						TGGCCATGATCCTGGACCCGC	0.617000													10	35					0	0	3.86212e-05	0	0
EDN3	1908	broad.mit.edu	37	20	57876672	57876672	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:57876672G>A	ENST00000311585.7	+	2	630	c.260G>A	c.(259-261)gGg>gAg	p.G87E	EDN3_ENST00000371028.2_Missense_Mutation_p.G87E|EDN3_ENST00000337938.2_Missense_Mutation_p.G87E|EDN3_ENST00000395654.3_Missense_Mutation_p.G87E|EDN3_ENST00000371025.3_Missense_Mutation_p.G87E	NM_207032.1	NP_996915.1	P14138	EDN3_HUMAN	endothelin 3	87					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	19	all_lung(29;0.0115)					GCGGCCGAGGGGGCCCCTGAG	0.642000													39	45					0	0	0.000270559	0	0
KCNQ3	3786	broad.mit.edu	37	8	133184869	133184869	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:133184869C>T	ENST00000388996.4	-	7	1536	c.1116G>A	c.(1114-1116)agG>agA	p.R372R	KCNQ3_ENST00000521134.1_Silent_p.R252R|KCNQ3_ENST00000519445.1_Silent_p.R372R	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	372					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CAGCTGGCTTCCTCCTTTTCT	0.552000													15	188					0	0	9.7654e-05	0	0
C6orf15	29113	broad.mit.edu	37	6	31079247	31079247	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:31079247G>A	ENST00000259870.3	-	2	892	c.889C>T	c.(889-891)Cct>Tct	p.P297S		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	297	Pro-rich.									endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						ACTCCAGGAGGAAATGGGTTA	0.522000													18	38					0	0	7.07596e-05	0	0
CCDC93	54520	broad.mit.edu	37	2	118732778	118732778	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:118732778G>A	ENST00000376300.2	-	9	873	c.736C>T	c.(736-738)Cga>Tga	p.R246*	CCDC93_ENST00000319432.5_Nonsense_Mutation_p.R245*|CCDC93_ENST00000460781.1_5'UTR	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	246										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						TCAGCTGCTCGAAGCTCATCT	0.502000													39	117					0	0	0.000147903	0	0
KIAA1462	57608	broad.mit.edu	37	10	30315246	30315246	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:30315246C>T	ENST00000375377.1	-	3	3932	c.3831G>A	c.(3829-3831)agG>agA	p.R1277R		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	1277										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						AGTCGGCATTCCTGAAGCTCA	0.622000													12	23					0	0	0.00010058	0	0
KIAA1009	22832	broad.mit.edu	37	6	84883856	84883856	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:84883856C>T	ENST00000403245.3	-	16	2191	c.2077G>A	c.(2077-2079)Gaa>Aaa	p.E693K	KIAA1009_ENST00000461137.1_5'UTR|KIAA1009_ENST00000257766.4_Missense_Mutation_p.E617K	NM_014895.2	NP_055710.2	Q5TB80	QN1_HUMAN	KIAA1009	693					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		TCAGCTGCTTCTCCAAAATGT	0.358000													12	7					0	0	6.40141e-05	0	0
ATXN7	6314	broad.mit.edu	37	3	63975917	63975917	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:63975917C>T	ENST00000398590.3	+	10	1980	c.1427C>T	c.(1426-1428)tCt>tTt	p.S476F	ATXN7_ENST00000538065.1_Missense_Mutation_p.S476F|ATXN7_ENST00000487717.1_Missense_Mutation_p.S476F|ATXN7_ENST00000484332.1_Missense_Mutation_p.S331F|ATXN7_ENST00000295900.6_Missense_Mutation_p.S476F	NM_001177387.1	NP_001170858.1	O15265	ATX7_HUMAN	ataxin 7	476	Pro-rich.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|stomach(1)|urinary_tract(3)	35		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		GTCCATGAATCTCCACACCCT	0.567000													7	37					0	0	0.000157383	0	0
ADAM29	11086	broad.mit.edu	37	4	175898916	175898916	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:175898916C>T	ENST00000359240.3	+	5	2910	c.2240C>T	c.(2239-2241)cCt>cTt	p.P747L	ADAM29_ENST00000404450.4_Missense_Mutation_p.P747L|ADAM29_ENST00000445694.1_Missense_Mutation_p.P747L|ADAM29_ENST00000514159.1_Missense_Mutation_p.P747L|RP13-577H12.2_ENST00000507525.1_RNA	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	747	9 X 9 AA approximate repeats.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CCTGTGACGCCTTCCCAGAGT	0.537000													9	34					0	0	0.000442599	0	0
SYCP2L	221711	broad.mit.edu	37	6	10912947	10912947	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:10912947C>T	ENST00000283141.6	+	13	1256	c.960C>T	c.(958-960)atC>atT	p.I320I	RP11-637O19.3_ENST00000480294.1_3'UTR|SYCP2L_ENST00000543878.1_Silent_p.I161I	NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	320						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			AATTTTGGATCGACTTCAACC	0.348000													16	89					0	0	9.7654e-05	0	0
C20orf26	26074	broad.mit.edu	37	20	20208996	20208996	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:20208996C>T	ENST00000245957.5	+	18	2112	c.2036C>T	c.(2035-2037)tCc>tTc	p.S679F	C20orf26_ENST00000497372.1_3'UTR|C20orf26_ENST00000377293.1_Missense_Mutation_p.S35F|C20orf26_ENST00000377309.2_Missense_Mutation_p.S35F|C20orf26_ENST00000389656.3_Missense_Mutation_p.S35F	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	679										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		GTTGGAATTTCCTTCCTAGAG	0.333000													44	172					0	0	0.000147903	0	0
DSG4	147409	broad.mit.edu	37	18	28989524	28989524	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr18:28989524G>A	ENST00000359747.4	+	13	2072	c.2043G>A	c.(2041-2043)tgG>tgA	p.W681*	RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Nonsense_Mutation_p.W681*|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	681					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TGCAGTCTTGGAGAATTGAAG	0.512000													21	70					0	0	7.16444e-05	0	0
TRIOBP	11078	broad.mit.edu	37	22	38155249	38155249	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:38155249T>C	ENST00000406386.3	+	17	6557	c.6302T>C	c.(6301-6303)aTc>aCc	p.I2101T	TRIOBP_ENST00000403663.2_Missense_Mutation_p.I388T|RP1-37E16.12_ENST00000455236.1_RNA|TRIOBP_ENST00000407319.2_Missense_Mutation_p.I388T	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	2101					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GATGGCCACATCCCCCCGGGC	0.602000													4	21					0	0	0.00024832	0	0
OR4A16	81327	broad.mit.edu	37	11	55111010	55111010	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:55111010C>T	ENST00000314721.2	+	1	384	c.334C>T	c.(334-336)Ctt>Ttt	p.L112F		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						AGAGGTCTTCCTTTTGGTGGT	0.443000													11	62					0	0	6.40141e-05	0	0
FGA	2243	broad.mit.edu	37	4	155507765	155507765	+	Silent	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:155507765T>A	ENST00000302053.3	-	5	894	c.816A>T	c.(814-816)ggA>ggT	p.G272G	FGA_ENST00000403106.3_Silent_p.G272G	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	272					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	AGGTGGAGCCTCCTCGAGTAA	0.542000													7	41					0	0	0.000157383	0	0
CECR1	51816	broad.mit.edu	37	22	17688149	17688149	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:17688149G>A	ENST00000399839.1	-	3	624	c.354C>T	c.(352-354)atC>atT	p.I118I	CECR1_ENST00000399837.2_Silent_p.I118I|CECR1_ENST00000262607.3_Silent_p.I118I|CECR1_ENST00000449907.2_Silent_p.I76I			Q9NZK5	CECR1_HUMAN	cat eye syndrome chromosome region, candidate 1	118					adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	25		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				CCATAGTCACGATGCCAATGT	0.552000													17	18					0	0	0.000175454	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156629388	156629388	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:156629388G>A	ENST00000296518.7	+	5	527	c.317_splice	c.e5-1	p.R106_splice	GUCY1A3_ENST00000511507.1_Splice_Site_p.R106_splice|GUCY1A3_ENST00000506455.1_Splice_Site_p.R106_splice|GUCY1A3_ENST00000513574.1_Splice_Site_p.R106_splice|GUCY1A3_ENST00000515602.1_3'UTR|GUCY1A3_ENST00000511108.1_Splice_Site_p.R106_splice|GUCY1A3_ENST00000455639.2_Splice_Site_p.R106_splice|GUCY1A3_ENST00000393832.3_5'UTR			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	106					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		ATATTTCCAGGAAATCTTTGG	0.264000													8	58					0	0	3.86212e-05	0	0
METTL22	79091	broad.mit.edu	37	16	8735995	8735995	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:8735995C>T	ENST00000381920.3	+	8	1096	c.838C>T	c.(838-840)Ccc>Tcc	p.P280S	METTL22_ENST00000561758.1_Missense_Mutation_p.P224S|METTL22_ENST00000568967.1_3'UTR	NM_024109.2	NP_077014.2	Q9BUU2	MET22_HUMAN	methyltransferase like 22	280							methyltransferase activity			large_intestine(5)|lung(4)	9						TCCCAAGGTCCCCTTCAGTTG	0.483000													15	41					0	0	0.000219431	0	0
BMP15	9210	broad.mit.edu	37	X	50659363	50659363	+	Missense_Mutation	SNP	C	C	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:50659363C>G	ENST00000252677.3	+	2	935	c.935C>G	c.(934-936)cCc>cGc	p.P312R		NM_005448.2	NP_005439.2	O95972	BMP15_HUMAN	bone morphogenetic protein 15	312					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(1)	26	Ovarian(276;0.236)					ATCATTGCTCCCCCTTTCTAC	0.483000													13	53					0	0	7.07596e-05	0	0
KRT71	112802	broad.mit.edu	37	12	52941659	52941659	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:52941659G>A	ENST00000267119.5	-	6	1155	c.1086C>T	c.(1084-1086)atC>atT	p.I362I		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	362	Coil 2.|Rod.						structural molecule activity	p.I362I(1)		breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		TCACGTTCTCGATCTCTGAGC	0.562000													23	164					0	0	9.22233e-05	0	0
CAGE1	285782	broad.mit.edu	37	6	7373880	7373880	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:7373880T>C	ENST00000502583.1	-	5	1736	c.1172A>G	c.(1171-1173)aAc>aGc	p.N391S	CAGE1_ENST00000512086.1_Missense_Mutation_p.N391S|CAGE1_ENST00000338150.4_Missense_Mutation_p.N391S|CAGE1_ENST00000296742.7_Missense_Mutation_p.N255S|CAGE1_ENST00000379918.4_Missense_Mutation_p.N391S	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	391										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					TTTTTGCGTGTTAGCTAAAAC	0.328000													34	38					0	0	0.000339439	0	0
EPHB1	2047	broad.mit.edu	37	3	134851843	134851843	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:134851843C>T	ENST00000398015.3	+	5	1619	c.1249C>T	c.(1249-1251)Ccc>Tcc	p.P417S	EPHB1_ENST00000493838.1_5'UTR	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	417	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						CAGCAAGAGTCCCTTCCCCCC	0.587000													8	21					0	0	3.86212e-05	0	0
PANK3	79646	broad.mit.edu	37	5	167995759	167995759	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:167995759G>A	ENST00000239231.6	-	2	589	c.273C>T	c.(271-273)gaC>gaT	p.D91D		NM_024594.3	NP_078870.1	Q9H999	PANK3_HUMAN	pantothenate kinase 3	91					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			NS(1)|cervix(2)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		AAGTAGGCAGGTCCTGGGTTG	0.433000													23	93					0	0	0.000295444	0	0
SCN4A	6329	broad.mit.edu	37	17	62019255	62019255	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:62019255G>A	ENST00000578147.1	-	24	4463	c.4387C>T	c.(4387-4389)Cgc>Tgc	p.R1463C	SCN4A_ENST00000435607.1_Missense_Mutation_p.R1463C			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1463					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TTGGCCCCGCGGATCAGCCGC	0.617000													6	17					0	0	8.12818e-05	0	0
NTRK3	4916	broad.mit.edu	37	15	88678351	88678351	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:88678351G>A	ENST00000394480.1	-	10	1506	c.1185C>T	c.(1183-1185)ttC>ttT	p.F395F	NTRK3_ENST00000557856.1_Silent_p.F395F|NTRK3_ENST00000355254.2_Silent_p.F395F|NTRK3_ENST00000542733.2_Silent_p.F297F|NTRK3_ENST00000540489.2_Silent_p.F395F|NTRK3_ENST00000317501.3_Silent_p.F395F|NTRK3_ENST00000360948.2_Silent_p.F395F|NTRK3_ENST00000558676.1_Silent_p.F395F|NTRK3_ENST00000357724.2_Silent_p.F395F	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	395					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GCTCCTTGAGGAAGTGGCCAT	0.537000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			42	83					0	0	0.000147903	0	0
SCN5A	6331	broad.mit.edu	37	3	38655513	38655513	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:38655513C>T	ENST00000413689.1	-	6	849	c.656G>A	c.(655-657)cGa>cAa	p.R219Q	SCN5A_ENST00000449557.2_Intron|SCN5A_ENST00000451551.2_Missense_Mutation_p.R219Q|SCN5A_ENST00000423572.2_Intron|SCN5A_ENST00000455624.2_Missense_Mutation_p.R219Q|SCN5A_ENST00000450102.2_Missense_Mutation_p.R219Q|SCN5A_ENST00000443581.1_Intron|SCN5A_ENST00000333535.4_Intron|SCN5A_ENST00000414099.2_Missense_Mutation_p.R219Q|SCN5A_ENST00000425664.1_Missense_Mutation_p.R219Q	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	219					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCTGAAAGTTCGAAGAGCCGA	0.433000													6	16					0	0	0.000157383	0	0
COL20A1	57642	broad.mit.edu	37	20	61938855	61938855	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:61938855C>T	ENST00000422202.1	+	5	599	c.531C>T	c.(529-531)ttC>ttT	p.F177F	COL20A1_ENST00000435874.1_Silent_p.F177F|COL20A1_ENST00000326996.6_Silent_p.F170F|COL20A1_ENST00000358894.6_Silent_p.F170F			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	170					cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					GCCCCCAGTTCCGCTGCCTGC	0.682000													7	15					0	0	0.000157383	0	0
SOGA3	387104	broad.mit.edu	37	6	127796649	127796649	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:127796649G>A	ENST00000556132.1	-	6	3386	c.2522C>T	c.(2521-2523)aCc>aTc	p.T841I	SOGA3_ENST00000525778.1_Missense_Mutation_p.T841I|SOGA3_ENST00000481848.2_Missense_Mutation_p.T841I|SOGA3_ENST00000474293.2_5'UTR|SOGA3_ENST00000368268.2_Missense_Mutation_p.T841I|SOGA3_ENST00000465909.2_Missense_Mutation_p.T841I	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	841						integral to membrane											GCGCGCCTCGGTGATGATGGT	0.652000													51	44					0	0	0.000147903	0	0
DAB2	1601	broad.mit.edu	37	5	39381706	39381706	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:39381706C>T	ENST00000545653.1	-	10	1821	c.1291G>A	c.(1291-1293)Gac>Aac	p.D431N	DAB2_ENST00000320816.6_Missense_Mutation_p.D452N|DAB2_ENST00000509337.1_Missense_Mutation_p.D431N|DAB2_ENST00000339788.6_Missense_Mutation_p.D234N	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	452					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			GCAAGCAAGTCATTGGCTGAA	0.527000													11	40					0	0	0.00010058	0	0
RAG2	5897	broad.mit.edu	37	11	36615566	36615566	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:36615566C>A	ENST00000311485.3	-	2	314	c.153G>T	c.(151-153)aaG>aaT	p.K51N		NM_000536.3|NM_001243785.1|NM_001243786.1	NP_000527.2|NP_001230714.1|NP_001230715.1	P55895	RAG2_HUMAN	recombination activating gene 2	51					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	32	all_lung(20;0.226)	all_hematologic(20;0.00756)				CATGGTTATGCTTTACATCCA	0.458000									Familial Hemophagocytic Lymphohistiocytosis				19	108					8.00594e-06	0.000166435	9.7654e-05	1	0
DHRS2	10202	broad.mit.edu	37	14	24114495	24114495	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:24114495C>T	ENST00000344777.7	+	9	1325	c.887C>T	c.(886-888)cCa>cTa	p.P296L	DHRS2_ENST00000250383.6_3'UTR	NM_182908.4	NP_878912.1	Q13268	DHRS2_HUMAN	dehydrogenase/reductase (SDR family) member 2	0					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00659)		GCTGTGGTCCCAGGCCCAGGA	0.597000													31	46					0	0	0.000491102	0	0
G6PC	2538	broad.mit.edu	37	17	41053008	41053008	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:41053008C>T	ENST00000253801.2	+	1	194	c.115C>T	c.(115-117)Ctc>Ttc	p.L39F	G6PC_ENST00000592383.1_Missense_Mutation_p.L39F|G6PC_ENST00000585489.1_Missense_Mutation_p.L39F	NM_000151.3	NP_000142.2	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	39					gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GATCGCAGACCTCAGGAATGC	0.498000													58	50					0	0	0.000147903	0	0
LILRB2	10288	broad.mit.edu	37	19	54783826	54783826	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:54783826G>A	ENST00000391748.1	-	4	302	c.175C>T	c.(175-177)Cgt>Tgt	p.R59C	LILRB2_ENST00000471216.1_5'UTR|LILRB2_ENST00000434421.1_Intron|LILRB2_ENST00000391746.1_Missense_Mutation_p.R59C|LILRB2_ENST00000314446.5_Missense_Mutation_p.R59C|LILRB2_ENST00000391749.4_Missense_Mutation_p.R59C	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	59	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTATATAGACGGTACTCCTGG	0.547000													28	129					0	0	9.22233e-05	0	0
FBXL6	26233	broad.mit.edu	37	8	145580326	145580326	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:145580326G>A	ENST00000331890.5	-	6	991	c.927C>T	c.(925-927)atC>atT	p.I309I	FBXL6_ENST00000526524.1_5'UTR|FBXL6_ENST00000455319.2_Silent_p.I303I	NM_012162.2	NP_036294.1	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6	309					proteolysis		ubiquitin-protein ligase activity			endometrium(1)|lung(3)|ovary(1)	5	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			TATTACGGTTGATGCCGGTGC	0.652000													11	101					0	0	6.40141e-05	0	0
SERTAD4	56256	broad.mit.edu	37	1	210415269	210415269	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:210415269C>T	ENST00000367012.3	+	4	888	c.658C>T	c.(658-660)Ccc>Tcc	p.P220S	SERTAD4_ENST00000490620.1_3'UTR	NM_019605.3	NP_062551.1	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	220	Ser-rich.						protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		TGcctcctctccctccgcctc	0.502000													14	47					0	0	0.000151284	0	0
TTN	7273	broad.mit.edu	37	2	179596099	179596099	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:179596099C>T	ENST00000589042.1	-	59	17618	c.17394G>A	c.(17392-17394)ggG>ggA	p.G5798G	TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Silent_p.G4554G|TTN_ENST00000591111.1_Silent_p.G5481G|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5481	Ig-like 39.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGACATATTTCCCATCATGCT	0.408000													28	63					0	0	0.000184323	0	0
OR4K2	390431	broad.mit.edu	37	14	20344937	20344937	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:20344937C>T	ENST00000298642.2	+	1	547	c.511C>T	c.(511-513)Ccc>Tcc	p.P171S		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATTCTGTGGTCCCTATGAGGT	0.478000													76	196					0	0	0.000147903	0	0
DGKK	139189	broad.mit.edu	37	X	50147080	50147080	+	RNA	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:50147080G>A	ENST00000376025.2	-	0	1104							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					GATAAGGCAGGAATGCTCTCT	0.463000													6	15					0	0	8.12818e-05	0	0
OR8B4	283162	broad.mit.edu	37	11	124294453	124294453	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:124294453G>A	ENST00000356130.3	-	1	336	c.315C>T	c.(313-315)ttC>ttT	p.F105F		NM_001005196.1	NP_001005196.1	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B, member 4	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(1)|urinary_tract(1)	32		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AATTGACAAAGAAACAGAAGA	0.433000													10	26					0	0	3.86212e-05	0	0
MRPL18	29074	broad.mit.edu	37	6	160212136	160212136	+	Missense_Mutation	SNP	C	C	T	rs11556776		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:160212136C>T	ENST00000367034.4	+	2	339	c.217C>T	c.(217-219)Ccc>Tcc	p.P73S	MRPL18_ENST00000480842.1_3'UTR	NM_014161.3	NP_054880.2	Q9H0U6	RM18_HUMAN	mitochondrial ribosomal protein L18	73					rRNA transport|translation	mitochondrial ribosome	5S rRNA binding|structural constituent of ribosome			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)	11		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.44e-18)|BRCA - Breast invasive adenocarcinoma(81;5.79e-06)		GACGGTGTTTCCCTCCCGTGA	0.522000													7	27					0	0	0.000157383	0	0
TRHR	7201	broad.mit.edu	37	8	110100443	110100443	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:110100443G>A	ENST00000518632.1	+	2	1053	c.702G>A	c.(700-702)tgG>tgA	p.W234*	TRHR_ENST00000311762.2_Nonsense_Mutation_p.W234*			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	234						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			CTAAGACATGGAAAAATGATT	0.378000													18	29					0	0	7.07596e-05	0	0
ALDH6A1	4329	broad.mit.edu	37	14	74537937	74537937	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:74537937G>A	ENST00000553458.1	-	6	789	c.691C>T	c.(691-693)Cct>Tct	p.P231S	AC005484.5_ENST00000492026.1_RNA|ALDH6A1_ENST00000350259.4_Missense_Mutation_p.P218S|CCDC176_ENST00000553773.1_Intron	NM_001278593.1|NM_005589.2	NP_001265522.1|NP_005580.1	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6 family, member A1	231						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity	p.P231T(1)		NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(3)|skin(3)	21				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	GTTCCATCAGGGGCACCAGAA	0.458000													11	96					0	0	6.40141e-05	0	0
TRAV12-1	28674	broad.mit.edu	37	14	22309433	22309433	+	RNA	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:22309433C>T	ENST00000390433.1	+	0	12																											TGATGATATCCTTGAGAGTTT	0.353000													14	44					0	0	0.000422831	0	0
OR13H1	347468	broad.mit.edu	37	X	130678899	130678899	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:130678899G>A	ENST00000338616.3	+	1	950	c.852G>A	c.(850-852)ttG>ttA	p.L284L		NM_001004486.1	NP_001004486.1	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H, member 1	284					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15	Acute lymphoblastic leukemia(192;0.000636)					CACCCATGTTGAACCCCCTGA	0.408000													11	15					0	0	0.00010058	0	0
PCLO	27445	broad.mit.edu	37	7	82763754	82763754	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:82763754C>T	ENST00000423517.2	-	3	3449	c.3112G>A	c.(3112-3114)Gct>Act	p.A1038T	PCLO_ENST00000333891.8_Missense_Mutation_p.A1038T	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	984					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGAGGCTCAGCTGTTAAAGAT	0.413000													18	30					0	0	7.07596e-05	0	0
CYP2C19	1557	broad.mit.edu	37	10	96535211	96535211	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:96535211G>A	ENST00000371321.3	+	3	478	c.396G>A	c.(394-396)cgG>cgA	p.R132R	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	132			R -> Q (in allele CYP2C19*6; loss of activity).		exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	TGACGCTGCGGAATTTTGGGA	0.507000													19	45					0	0	0.000229342	0	0
TBC1D14	57533	broad.mit.edu	37	4	6925405	6925405	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:6925405C>T	ENST00000409757.4	+	2	413	c.289C>T	c.(289-291)Ccc>Tcc	p.P97S	TBC1D14_ENST00000448507.1_Missense_Mutation_p.P97S	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	97						intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						CGACCTCATCCCCGAGCGGGC	0.667000													11	87					0	0	0.000219431	0	0
ZMAT4	79698	broad.mit.edu	37	8	40554818	40554818	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:40554818G>A	ENST00000297737.6	-	4	441	c.295C>T	c.(295-297)Cac>Tac	p.H99Y	ZMAT4_ENST00000315769.7_Missense_Mutation_p.H99Y	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	99						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			CTCTTGGCGTGGATTTTGCCT	0.493000													29	67					0	0	0.000279167	0	0
NOS1	4842	broad.mit.edu	37	12	117696212	117696212	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:117696212C>T	ENST00000317775.6	-	16	3206	c.2521G>A	c.(2521-2523)Gaa>Aaa	p.E841K	NOS1_ENST00000338101.4_Missense_Mutation_p.E841K|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	841	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TTCCTTTCTTCCTGCACAGAG	0.483000													20	29					0	0	0.000375601	0	0
IL17A	3605	broad.mit.edu	37	6	52051240	52051240	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:52051240G>A	ENST00000340057.1	+	1	56	c.11G>A	c.(10-12)gGg>gAg	p.G4E		NM_002190.2	NP_002181.1	Q16552	IL17_HUMAN	interleukin 17A	4					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity			endometrium(3)|large_intestine(2)|lung(8)|prostate(3)|skin(1)	17	Lung NSC(77;0.116)					ATGACTCCTGGGAAGACCTCA	0.478000													8	28					0	0	0.000157383	0	0
LAMB4	22798	broad.mit.edu	37	7	107746344	107746344	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:107746344C>T	ENST00000388781.3	-	8	871	c.788G>A	c.(787-789)gGa>gAa	p.G263E	LAMB4_ENST00000205386.4_Missense_Mutation_p.G263E|LAMB4_ENST00000414450.2_Missense_Mutation_p.G263E|LAMB4_ENST00000388780.3_Missense_Mutation_p.G263E	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	263	Laminin N-terminal.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						AAAGCAGCTTCCCCGAACAAT	0.468000													9	55					0	0	0.000442599	0	0
MYH1	4619	broad.mit.edu	37	17	10401063	10401063	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:10401063C>T	ENST00000226207.5	-	31	4447	c.4353G>A	c.(4351-4353)agG>agA	p.R1451R	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1451				R -> T (in Ref. 4; CAA27380).		muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TATCAAAGTTCCTTTGCTTTT	0.443000													22	53					0	0	0.000227799	0	0
MCOLN1	57192	broad.mit.edu	37	19	7595243	7595243	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:7595243C>T	ENST00000264079.6	+	12	1556	c.1431C>T	c.(1429-1431)ttC>ttT	p.F477F		NM_020533.2	NP_065394.1	Q9GZU1	MCLN1_HUMAN	mucolipin 1	477					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TTGTGACGTTCGCCGCCATGC	0.597000													20	178					0	0	0.000295444	0	0
AGO2	27161	broad.mit.edu	37	8	141566090	141566090	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:141566090G>A	ENST00000220592.5	-	10	1286	c.1174C>T	c.(1174-1176)Cca>Tca	p.P392S	AGO2_ENST00000519980.1_Missense_Mutation_p.P392S	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		CGGACGTATGGATCTGTGTTG	0.562000													35	66					0	0	0.000319135	0	0
HIVEP3	59269	broad.mit.edu	37	1	42049495	42049495	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:42049495G>A	ENST00000372584.1	-	3	1988	c.974C>T	c.(973-975)tCc>tTc	p.S325F	HIVEP3_ENST00000429157.2_Missense_Mutation_p.S325F|HIVEP3_ENST00000372583.1_Missense_Mutation_p.S325F|HIVEP3_ENST00000247584.5_Missense_Mutation_p.S325F	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	325	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).|Ser-rich.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CTGGGACAGGGAACAGCGTTC	0.602000													13	86					0	0	0.000151284	0	0
SPATA2	9825	broad.mit.edu	37	20	48522753	48522753	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:48522753G>A	ENST00000422556.1	-	3	1315	c.966C>T	c.(964-966)gcC>gcT	p.A322A	SPATA2_ENST00000543716.1_Silent_p.A185A|SPATA2_ENST00000289431.5_Silent_p.A322A	NM_001135773.1	NP_001129245.1	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	322					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	20	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			CGCGCAGCAGGGCCGGGCCGT	0.662000													18	65					0	0	0.000375601	0	0
PHLDB3	653583	broad.mit.edu	37	19	43998878	43998878	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:43998878G>A	ENST00000292140.5	-	9	1485	c.1125C>T	c.(1123-1125)ctC>ctT	p.L375L		NM_198850.3	NP_942147.3	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B, member 3	375										breast(1)|central_nervous_system(1)|lung(5)	7		Prostate(69;0.0153)				GGACAGAAAAGAGGCAGGAAG	0.597000													7	22					0	0	0.000274275	0	0
CR1	1378	broad.mit.edu	37	1	207812749	207812749	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:207812749C>T	ENST00000367049.4	+	47	7465	c.7465C>T	c.(7465-7467)Cct>Tct	p.P2489S	CR1_ENST00000400960.2_Missense_Mutation_p.P2039S|CR1_ENST00000367053.1_Missense_Mutation_p.P2039S|CR1_ENST00000367052.1_Missense_Mutation_p.P2039S|CR1_ENST00000367051.1_Missense_Mutation_p.P2039S	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	2039					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CAGGGTCCTTCCTTGACAAAG	0.363000													7	9					0	0	0.000274275	0	0
DNAH2	146754	broad.mit.edu	37	17	7690336	7690336	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:7690336C>T	ENST00000572933.1	+	42	8048	c.6588C>T	c.(6586-6588)atC>atT	p.I2196I	DNAH2_ENST00000389173.2_Silent_p.I2196I			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2196	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCGAGCGCATCGCGATGCCCG	0.637000													7	19					0	0	8.12818e-05	0	0
RIF1	55183	broad.mit.edu	37	2	152300166	152300166	+	Silent	SNP	G	G	A	rs140493456	byFrequency	TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:152300166G>A	ENST00000243326.4	+	17	2412	c.1929G>A	c.(1927-1929)gaG>gaA	p.E643E	RIF1_ENST00000453091.2_Silent_p.E643E|RIF1_ENST00000444746.2_Silent_p.E643E|RIF1_ENST00000430328.2_Silent_p.E643E|RIF1_ENST00000428287.2_Silent_p.E643E			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	643					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AAAATAAGGAGCATCTCTGGA	0.348000													91	60					0	0	0.000147903	0	0
DNAH5	1767	broad.mit.edu	37	5	13864563	13864563	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:13864563G>A	ENST00000265104.4	-	28	4643	c.4539C>T	c.(4537-4539)agC>agT	p.S1513S	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1513	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTAACTTAAAGCTTTCATTCC	0.468000									Kartagener syndrome				23	29					0	0	0.000295444	0	0
BIRC6	57448	broad.mit.edu	37	2	32712717	32712717	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:32712717C>T	ENST00000421745.2	+	41	7951	c.7817C>T	c.(7816-7818)tCa>tTa	p.S2606L		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	2606					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TTTTCAGTATCACAGTCTCCC	0.318000													18	61					0	0	0.000295444	0	0
HYDIN	54768	broad.mit.edu	37	16	71103214	71103214	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:71103214G>A	ENST00000393567.2	-	14	2080	c.1930C>T	c.(1930-1932)Cct>Tct	p.P644S	HYDIN_ENST00000448691.1_Missense_Mutation_p.P644S|HYDIN_ENST00000448089.2_Missense_Mutation_p.P644S|HYDIN_ENST00000393550.2_Missense_Mutation_p.P659S|HYDIN_ENST00000541601.1_Missense_Mutation_p.P661S|HYDIN_ENST00000321489.5_Missense_Mutation_p.P644S|HYDIN_ENST00000288168.10_Missense_Mutation_p.P661S|HYDIN_ENST00000538248.1_Missense_Mutation_p.P671S	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	644										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CCACAGTCAGGAGAGATGGTG	0.453000													4	36					0	0	3.86212e-05	0	0
NAIP	4671	broad.mit.edu	37	5	70308413	70308413	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:70308413C>T	ENST00000517649.1	-	4	620	c.330G>A	c.(328-330)acG>acA	p.T110T	NAIP_ENST00000194097.4_Silent_p.T110T|NAIP_ENST00000523981.1_Intron|NAIP_ENST00000503719.2_Intron|NAIP_ENST00000508426.2_Silent_p.T110T	NM_004536.2	NP_004527.2	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein	110					anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		TGGGGAGTCTCGTGAGGCCGG	0.493000													14	60					0	0	0.000151284	0	0
ALDH6A1	4329	broad.mit.edu	37	14	74541683	74541683	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:74541683G>A	ENST00000553458.1	-	2	184	c.86C>T	c.(85-87)tCa>tTa	p.S29L	AC005484.5_ENST00000492026.1_RNA|ALDH6A1_ENST00000350259.4_Missense_Mutation_p.S29L|ALDH6A1_ENST00000556852.1_5'UTR|CCDC176_ENST00000553773.1_Intron	NM_001278593.1|NM_005589.2	NP_001265522.1|NP_005580.1	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6 family, member A1	29						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(3)|skin(3)	21				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	GGAAGATGCTGAATACCAGGT	0.368000													8	53					0	0	0.00010058	0	0
FCRL5	83416	broad.mit.edu	37	1	157497543	157497543	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:157497543C>T	ENST00000361835.3	-	9	1981	c.1824G>A	c.(1822-1824)ggG>ggA	p.G608G	FCRL5_ENST00000368190.3_Silent_p.G608G|FCRL5_ENST00000368191.3_Silent_p.G523G|FCRL5_ENST00000356953.4_Silent_p.G608G	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	608	Ig-like C2-type 6.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CTGAGCTGCTCCCCAGGGTGA	0.567000													19	27					0	0	0.000132079	0	0
VPS13C	54832	broad.mit.edu	37	15	62223331	62223331	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:62223331G>A	ENST00000261517.5	-	50	6069	c.5996C>T	c.(5995-5997)aCc>aTc	p.T1999I	VPS13C_ENST00000249837.3_Missense_Mutation_p.T1956I|VPS13C_ENST00000395896.4_Missense_Mutation_p.T1999I|VPS13C_ENST00000395898.3_Missense_Mutation_p.T1956I	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	1999					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						ATCATCAAGGGTGCATGTCTT	0.428000													30	40					0	0	8.91981e-05	0	0
ZZEF1	23140	broad.mit.edu	37	17	3999198	3999198	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:3999198C>T	ENST00000381638.2	-	11	1964	c.1840G>A	c.(1840-1842)Gaa>Aaa	p.E614K	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	614							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						AAGTGTTCTTCCGCACAAAAT	0.398000													53	32					0	0	0.000147903	0	0
DOCK8	81704	broad.mit.edu	37	9	382626	382626	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:382626G>A	ENST00000432829.2	+	22	2831	c.2515G>A	c.(2515-2517)Gac>Aac	p.D839N	DOCK8_ENST00000382329.1_Missense_Mutation_p.D374N|DOCK8_ENST00000382331.1_Missense_Mutation_p.D209N|DOCK8_ENST00000453981.1_Missense_Mutation_p.D907N|DOCK8_ENST00000469391.1_Missense_Mutation_p.D839N	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	907					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CAGTAACCCAGACCTCGCGGG	0.562000													9	29					0	0	0.000442599	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54661864	54661864	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:54661864G>A	ENST00000474759.1	+	10	1062	c.1014G>A	c.(1012-1014)ttG>ttA	p.L338L	CACNA2D3_ENST00000490478.1_Silent_p.L244L|CACNA2D3_ENST00000288197.5_Silent_p.L338L|CACNA2D3_ENST00000415676.2_Silent_p.L338L	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	338	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TTGGAATGTTGGATATAGCTC	0.408000													4	23					0	0	3.59834e-05	0	0
TRIB1	10221	broad.mit.edu	37	8	126448703	126448703	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:126448703T>C	ENST00000311922.3	+	3	1691	c.1109T>C	c.(1108-1110)tTc>tCc	p.F370S	TRIB1_ENST00000520847.1_Missense_Mutation_p.F204S|TRIB1_ENST00000519576.1_Missense_Mutation_p.F139S	NM_025195.2	NP_079471.1	Q96RU8	TRIB1_HUMAN	tribbles pseudokinase 1	370					JNK cascade|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity|response to lipopolysaccharide	cytoplasm|nucleus	ATP binding|mitogen-activated protein kinase kinase binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			NS(1)|large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	8	all_hematologic(1;4.97e-05)|Ovarian(258;0.00167)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			ATTAGTTCCTTCTTCTGCTAA	0.463000													94	157					0	0	0.000147903	0	0
HTR7	3363	broad.mit.edu	37	10	92509030	92509030	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:92509030G>A	ENST00000371721.3	-	2	1103	c.861C>T	c.(859-861)atC>atT	p.I287I	HTR7_ENST00000371719.2_Silent_p.I287I|HTR7_ENST00000277874.6_Silent_p.I287I|HTR7_ENST00000336152.3_Silent_p.I287I			P34969	5HT7R_HUMAN	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	287					blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	CATTCAGGGCGATGACGCTGT	0.488000													4	17					0	0	1.23904e-05	0	0
RSBN1	54665	broad.mit.edu	37	1	114310987	114310987	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:114310987G>A	ENST00000261441.5	-	5	1746	c.1683C>T	c.(1681-1683)ctC>ctT	p.L561L		NM_018364.3	NP_060834.2	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	561						nucleus				breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(3)|urinary_tract(2)	29	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTAGGTACTGGAGATTTTTTA	0.398000													5	61					0	0	1.23904e-05	0	0
ZZEF1	23140	broad.mit.edu	37	17	3917765	3917765	+	Missense_Mutation	SNP	G	G	C	rs142020410		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:3917765G>C	ENST00000381638.2	-	50	8314	c.8190C>G	c.(8188-8190)ttC>ttG	p.F2730L		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	2730							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						ACTGAGAGTCGAATTTGATTG	0.517000													52	51					0	0	0.000147903	0	0
CC2D2A	57545	broad.mit.edu	37	4	15512933	15512933	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:15512933G>A	ENST00000424120.1	+	8	858	c.604G>A	c.(604-606)Gaa>Aaa	p.E202K	CC2D2A_ENST00000503292.1_Missense_Mutation_p.E202K|CC2D2A_ENST00000389652.5_Missense_Mutation_p.E153K|CC2D2A_ENST00000413206.1_Missense_Mutation_p.E202K|CC2D2A_ENST00000513811.1_3'UTR			Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A	202					cell projection organization	cilium|microtubule basal body				NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|urinary_tract(2)	32						CTTTGATCCCGAACCAGAAGG	0.463000													8	10					0	0	0.000157383	0	0
XIRP1	165904	broad.mit.edu	37	3	39225770	39225770	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:39225770C>T	ENST00000340369.3	-	2	5395	c.5167G>A	c.(5167-5169)Gac>Aac	p.D1723N	XIRP1_ENST00000421646.1_Missense_Mutation_p.D406N|XIRP1_ENST00000396251.1_3'UTR	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1723	Interaction with FLNC.						actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGGGTGATGTCCTTCTTCCCA	0.582000													14	35					0	0	0.000151284	0	0
TAS1R2	80834	broad.mit.edu	37	1	19186034	19186034	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:19186034G>A	ENST00000375371.3	-	1	142	c.121C>T	c.(121-123)Ctc>Ttc	p.L41F	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	41					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	TTGGCATGGAGGGAGAAGAGG	0.577000													12	50					0	0	0.000219431	0	0
RIPK4	54101	broad.mit.edu	37	21	43162041	43162041	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr21:43162041C>T	ENST00000352483.2	-	9	1520	c.1456G>A	c.(1456-1458)Ggt>Agt	p.G486S	RIPK4_ENST00000542057.1_Missense_Mutation_p.G375S|RIPK4_ENST00000544709.1_Missense_Mutation_p.G375S|RIPK4_ENST00000332512.3_Missense_Mutation_p.G438S			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	438						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						AGGCTGGCACCGCTGTCCAGT	0.627000													38	73					0	0	0.000159656	0	0
TP53	7157	broad.mit.edu	37	17	7577082	7577082	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:7577082C>T	ENST00000420246.2	-	8	988	c.856G>A	c.(856-858)Gaa>Aaa	p.E286K	TP53_ENST00000455263.2_Missense_Mutation_p.E286K|TP53_ENST00000269305.4_Missense_Mutation_p.E286K|TP53_ENST00000359597.4_Missense_Mutation_p.E286K|TP53_ENST00000445888.2_Missense_Mutation_p.E286K|TP53_ENST00000413465.2_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	286	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> Q (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E286K(58)|p.E286*(22)|p.0?(8)|p.E286Q(5)|p.?(2)|p.E286fs*59(2)|p.E286fs*17(2)|p.R283fs*16(2)|p.R282_E287delRRTEEE(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.T284_G293del10(1)|p.E285_L289delEEENL(1)|p.R283fs*56(1)|p.E285fs*13(1)|p.G279fs*59(1)|p.R283fs*59(1)|p.V272_K292del21(1)|p.E285_N288delEEEN(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGATTCTCTTCCTCTGTGCGC	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	8					0	0	5.01169e-05	0	0
ZNF711	7552	broad.mit.edu	37	X	84526058	84526058	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:84526058C>T	ENST00000360700.4	+	10	2534	c.1648C>T	c.(1648-1650)Cct>Tct	p.P550S	ZNF711_ENST00000373165.3_Missense_Mutation_p.P504S|ZNF711_ENST00000395402.1_Missense_Mutation_p.P512S|ZNF711_ENST00000276123.3_Missense_Mutation_p.P504S|ZNF711_ENST00000542798.1_Missense_Mutation_p.P346S			Q9Y462	ZN711_HUMAN	zinc finger protein 711	504					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						CAAGAATTTTCCTCATGTTTG	0.433000													6	1					0	0	8.12818e-05	0	0
ANK2	287	broad.mit.edu	37	4	114288909	114288909	+	Silent	SNP	C	C	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:114288909C>G	ENST00000357077.4	+	42	11273	c.11220C>G	c.(11218-11220)ctC>ctG	p.L3740L	ANK2_ENST00000510275.2_Silent_p.L307L|ANK2_ENST00000394537.3_Silent_p.L1655L|ANK2_ENST00000264366.6_Silent_p.L3707L|ANK2_ENST00000506722.1_Silent_p.L1646L|ANK2_ENST00000509550.1_Silent_p.L831L	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3707					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAACAGCACTCTTTCCCCAAA	0.468000													20	33					0	0	0.000229342	0	0
TAOK1	57551	broad.mit.edu	37	17	27807479	27807479	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:27807479C>T	ENST00000261716.3	+	7	1062	c.543C>T	c.(541-543)tcC>tcT	p.S181S	TAOK1_ENST00000536202.1_Silent_p.S181S	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	181	Protein kinase.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			CTGCCAATTCCTTTGTGGGAA	0.418000													20	24					0	0	0.000375601	0	0
ERO1L	30001	broad.mit.edu	37	14	53112975	53112975	+	Silent	SNP	A	A	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:53112975A>G	ENST00000395686.3	-	15	1466	c.1243T>C	c.(1243-1245)Tta>Cta	p.L415L		NM_014584.1	NP_055399.1	Q96HE7	ERO1A_HUMAN	ERO1-like (S. cerevisiae)	415					chaperone mediated protein folding requiring cofactor|electron transport chain|protein thiol-disulfide exchange|response to temperature stimulus|transport	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome	disulfide oxidoreductase activity|flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor		ERO1L/FERMT2(2)	breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12	Breast(41;0.226)					TCAGAAAATAAGATCTTCAGA	0.328000													5	131					0	0	1.23904e-05	0	0
ZNF546	339327	broad.mit.edu	37	19	40521320	40521320	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:40521320C>T	ENST00000347077.4	+	7	2359	c.2143C>T	c.(2143-2145)Cac>Tac	p.H715Y	ZNF546_ENST00000596894.1_Intron|ZNF546_ENST00000600094.1_Missense_Mutation_p.H689Y	NM_178544.3	NP_848639.2	Q86UE3	ZN546_HUMAN	zinc finger protein 546	715					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(15)|lung(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	34	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCAAAGAATTCACACTGGTGA	0.388000													26	38					0	0	0.000147802	0	0
TBCK	93627	broad.mit.edu	37	4	107154798	107154798	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:107154798G>A	ENST00000273980.4	-	17	1906	c.1459C>T	c.(1459-1461)Cat>Tat	p.H487Y	TBCK_ENST00000432496.2_Missense_Mutation_p.H487Y|TBCK_ENST00000394706.3_Missense_Mutation_p.H448Y|TBCK_ENST00000394708.2_Missense_Mutation_p.H487Y|TBCK_ENST00000361687.4_Missense_Mutation_p.H424Y			Q8TEA7	TBCK_HUMAN	TBC1 domain containing kinase	487	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	25						TACTTGGCATGAATAGCTCCC	0.274000													4	13					0	0	1.23904e-05	0	0
SERTM1	400120	broad.mit.edu	37	13	37269376	37269376	+	Missense_Mutation	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr13:37269376T>A	ENST00000315190.3	+	2	607	c.161T>A	c.(160-162)tTt>tAt	p.F54Y		NM_203451.2	NP_982276.2	A2A2V5	CM036_HUMAN	serine-rich and transmembrane domain containing 1	54						integral to membrane		p.F54C(1)									CTTTTAGCGTTTCTGCTTCTG	0.493000													17	67					0	0	0.000375601	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18808538	18808538	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:18808538C>T	ENST00000400664.1	+	1	1115	c.1063C>T	c.(1063-1065)Ccc>Tcc	p.P355S		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	355						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		AGGGCCGTGGCCCTCCACCCG	0.687000													6	20					0	0	0.000157383	0	0
SDR42E1	93517	broad.mit.edu	37	16	82032986	82032986	+	Silent	SNP	G	G	A	rs1143453		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:82032986G>A	ENST00000328945.5	-	3	1039	c.912C>T	c.(910-912)ctC>ctT	p.L304L		NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	304					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						GGAAGTTGTAGAGTCGACCCA	0.463000													16	25					0	0	9.7654e-05	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6530406	6530406	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:6530406C>T	ENST00000377748.1	-	17	2418	c.1921G>A	c.(1921-1923)Gaa>Aaa	p.E641K	PLEKHG5_ENST00000377732.1_Missense_Mutation_p.E601K|PLEKHG5_ENST00000400913.1_Missense_Mutation_p.E564K|PLEKHG5_ENST00000400915.3_Missense_Mutation_p.E620K|PLEKHG5_ENST00000535355.1_Missense_Mutation_p.E633K|PLEKHG5_ENST00000544978.1_Missense_Mutation_p.E564K|PLEKHG5_ENST00000537245.1_Missense_Mutation_p.E643K|PLEKHG5_ENST00000377740.3_Missense_Mutation_p.E641K|PLEKHG5_ENST00000377728.3_Missense_Mutation_p.E564K|PLEKHG5_ENST00000340850.5_Missense_Mutation_p.E564K|PLEKHG5_ENST00000377737.2_Missense_Mutation_p.E564K|PLEKHG5_ENST00000377725.1_Missense_Mutation_p.E564K	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	620	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		TGCAGAAATTCCTTCAGGAGC	0.637000													4	21					0	0	0.00024832	0	0
PDE1A	5136	broad.mit.edu	37	2	183104841	183104841	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:183104841C>T	ENST00000435564.1	-	3	594	c.394G>A	c.(394-396)Gaa>Aaa	p.E132K	PDE1A_ENST00000536095.1_Missense_Mutation_p.E28K|PDE1A_ENST00000351439.5_Missense_Mutation_p.E116K|PDE1A_ENST00000409365.1_Missense_Mutation_p.E116K|PDE1A_ENST00000456212.1_Missense_Mutation_p.E132K|PDE1A_ENST00000346717.4_Missense_Mutation_p.E98K|PDE1A_ENST00000358139.2_Missense_Mutation_p.E132K|PDE1A_ENST00000410103.1_Missense_Mutation_p.E132K|PDE1A_ENST00000331935.6_Missense_Mutation_p.E132K|PDE1A_ENST00000482538.1_5'UTR	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	132					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			ACTTACCTTTCCACAAAAATT	0.363000													33	80					0	0	0.000159656	0	0
LRP1	4035	broad.mit.edu	37	12	57588878	57588878	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:57588878C>T	ENST00000243077.3	+	51	8768	c.8302C>T	c.(8302-8304)Cac>Tac	p.H2768Y		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2768	LDL-receptor class A 16.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CGAGGCTGCTCACTGTGGTAA	0.632000													38	38					0	0	0.000106405	0	0
KDM3B	51780	broad.mit.edu	37	5	137726914	137726914	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:137726914C>T	ENST00000314358.5	+	8	1793	c.1593C>T	c.(1591-1593)tcC>tcT	p.S531S	KDM3B_ENST00000394866.1_Silent_p.S187S|KDM3B_ENST00000542866.1_Intron	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	531					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						AATGCATGTCCCAAACTTTAC	0.428000													15	39					0	0	0.000422831	0	0
KLHL17	339451	broad.mit.edu	37	1	898107	898107	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:898107C>T	ENST00000338591.3	+	6	959	c.852C>T	c.(850-852)ccC>ccT	p.P284P		NM_198317.2	NP_938073.1	Q6TDP4	KLH17_HUMAN	kelch-like family member 17	284	BACK.				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold			central_nervous_system(1)|kidney(2)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TGCGGCTGCCCTTGCTGAGCC	0.657000													5	21					0	0	1.23904e-05	0	0
AVPR2	554	broad.mit.edu	37	X	153171107	153171107	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:153171107G>A	ENST00000358927.2	+	3	356	c.147G>A	c.(145-147)gtG>gtA	p.V49V	AVPR2_ENST00000337474.5_Silent_p.V49V|AVPR2_ENST00000370049.1_Silent_p.V49V			P30518	V2R_HUMAN	arginine vasopressin receptor 2	49					activation of adenylate cyclase activity|excretion|G-protein signaling, coupled to cAMP nucleotide second messenger|hemostasis|positive regulation of gene expression|transmembrane transport|water transport	endoplasmic reticulum|endosome|Golgi apparatus|integral to plasma membrane	vasopressin receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	26	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Conivaptan(DB00872)|Terlipressin(DB02638)|Vasopressin(DB00067)	TAGTCTTTGTGGCTGTGGCCC	0.692000													5	10					0	0	3.59834e-05	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854208	12854208	+	Missense_Mutation	SNP	C	C	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:12854208C>G	ENST00000332296.7	+	3	535	c.432C>G	c.(430-432)caC>caG	p.H144Q		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	144										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGGGAGAGCACCAGCCCTTAA	0.537000													23	186					0	0	0.000227799	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141106	143141106	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:143141106C>T	ENST00000332690.1	+	1	561	c.561C>T	c.(559-561)agC>agT	p.S187S	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	187					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					GCATACGGAGCTACTGTGAGA	0.398000													17	182					0	0	7.07596e-05	0	0
PALMD	54873	broad.mit.edu	37	1	100152699	100152699	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:100152699G>A	ENST00000263174.4	+	6	843	c.468G>A	c.(466-468)agG>agA	p.R156R	PALMD_ENST00000605497.1_Silent_p.R156R	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	156					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		CTAGGTTAAGGAAGGAGATAA	0.318000													16	70					0	0	0.000229342	0	0
CR1	1378	broad.mit.edu	37	1	207812750	207812750	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:207812750C>T	ENST00000367049.4	+	47	7466	c.7466C>T	c.(7465-7467)cCt>cTt	p.P2489L	CR1_ENST00000400960.2_Missense_Mutation_p.P2039L|CR1_ENST00000367053.1_Missense_Mutation_p.P2039L|CR1_ENST00000367052.1_Missense_Mutation_p.P2039L|CR1_ENST00000367051.1_Missense_Mutation_p.P2039L	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	2039					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						AGGGTCCTTCCTTGACAAAGT	0.368000													7	8					0	0	0.000274275	0	0
ATMIN	23300	broad.mit.edu	37	16	81077589	81077589	+	Missense_Mutation	SNP	A	A	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:81077589A>T	ENST00000566488.1	+	3	1981	c.1018A>T	c.(1018-1020)Agt>Tgt	p.S340C	ATMIN_ENST00000299575.4_Missense_Mutation_p.S496C|ATMIN_ENST00000564241.1_Missense_Mutation_p.S340C|ATMIN_ENST00000539819.1_3'UTR			O43313	ATMIN_HUMAN	ATM interactor	496	Required for formation of RAD51 foci.				response to DNA damage stimulus	nucleus	zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	20						AACTCAAACCAGTGGGATAGA	0.448000													17	36					0	0	5.01169e-05	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497688	1497688	+	Silent	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:1497688T>C	ENST00000421627.2	+	2	963	c.829T>C	c.(829-831)Ttg>Ctg	p.L277L		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	356					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CTGTGAGGGGTTGGCGCTGAC	0.652000													15	20					0	0	7.07596e-05	0	0
TUBAL3	79861	broad.mit.edu	37	10	5435601	5435601	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:5435601G>A	ENST00000380419.3	-	4	1257	c.1220C>T	c.(1219-1221)gCc>gTc	p.A407V	TUBAL3_ENST00000479328.1_Missense_Mutation_p.A367V	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	407					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						TGCTCTCTTGGCGTACATGAG	0.577000													8	27					0	0	0.000442599	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84700118	84700118	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:84700118G>A	ENST00000286744.5	+	28	4912	c.4688G>A	c.(4687-4689)aGg>aAg	p.R1563K	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.R1563K	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1563						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CGTGCTGTGAGGATGCAGCAG	0.522000													29	214					0	0	0.000109025	0	0
SCN1A	6323	broad.mit.edu	37	2	166848898	166848898	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:166848898G>A	ENST00000423058.2	-	26	4904	c.4887C>T	c.(4885-4887)ttC>ttT	p.F1629F	SCN1A_ENST00000409050.1_Silent_p.F1601F|AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Silent_p.F1629F|SCN1A_ENST00000375405.3_Silent_p.F1618F	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1629						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.F1618F(1)		NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TAGGGGACACGAAATACTTTT	0.433000													21	15					0	0	7.16444e-05	0	0
CBLN4	140689	broad.mit.edu	37	20	54575808	54575808	+	Silent	SNP	G	G	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:54575808G>C	ENST00000064571.2	-	2	1687	c.387C>G	c.(385-387)gtC>gtG	p.V129V		NM_080617.4	NP_542184.1	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	129	C1q.					cell junction|extracellular region|synapse				endometrium(2)|large_intestine(1)|lung(10)|ovary(3)|pancreas(1)	17			Colorectal(105;0.202)			GGCTCTGGTAGACTTTAATCA	0.373000													6	146					0	0	0.000157383	0	0
MMAA	166785	broad.mit.edu	37	4	146560327	146560327	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:146560327C>T	ENST00000281317.5	+	2	1246	c.36C>T	c.(34-36)ttC>ttT	p.F12F	MMAA_ENST00000541599.1_5'UTR	NM_172250.2	NP_758454.1	Q8IVH4	MMAA_HUMAN	methylmalonic aciduria (cobalamin deficiency) cblA type	12						mitochondrion	GTP binding|nucleoside-triphosphatase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)	17	all_hematologic(180;0.151)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACCAGCATTTCCTAAAAGGCC	0.438000													14	130					0	0	5.01169e-05	0	0
GCK	2645	broad.mit.edu	37	7	44189372	44189372	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:44189372G>A	ENST00000403799.3	-	6	1135	c.666C>T	c.(664-666)gtC>gtT	p.V222V	GCK_ENST00000345378.2_Silent_p.V223V|GCK_ENST00000395796.3_Silent_p.V221V|GCK_ENST00000437084.1_Silent_p.V205V	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	222					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding	p.V223V(1)		central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						CGATCATGCCGACCTCGCACT	0.577000													118	204					0	0	0.000147903	0	0
SPPL2C	162540	broad.mit.edu	37	17	43923759	43923759	+	Missense_Mutation	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:43923759T>A	ENST00000329196.5	+	1	1504	c.1487T>A	c.(1486-1488)aTg>aAg	p.M496K	MAPT-AS1_ENST00000579599.1_RNA|MAPT-AS1_ENST00000579244.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	496						integral to membrane	aspartic-type endopeptidase activity										CTCATGCAGATGGGCCAACCT	0.612000													48	23					0	0	0.000147903	0	0
FBXW12	285231	broad.mit.edu	37	3	48414292	48414292	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:48414292G>A	ENST00000296438.5	+	2	221	c.35G>A	c.(34-36)cGa>cAa	p.R12Q	FBXW12_ENST00000436231.1_Intron|FBXW12_ENST00000445170.1_Intron|FBXW12_ENST00000415155.1_Missense_Mutation_p.R12Q	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	12	F-box.									breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCTTTGAAGCGAATCTTCTCT	0.537000													32	88					0	0	8.91981e-05	0	0
BAZ2A	11176	broad.mit.edu	37	12	56993772	56993772	+	Silent	SNP	G	G	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:56993772G>C	ENST00000179765.5	-	26	5110	c.4911C>G	c.(4909-4911)gcC>gcG	p.A1637A	BAZ2A_ENST00000379441.3_Silent_p.A1639A|BAZ2A_ENST00000551812.1_Silent_p.A1669A|BAZ2A_ENST00000549884.1_Silent_p.A1667A			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	1669					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						ACTTCTCCCAGGCAATGGACC	0.652000													15	70					0	0	7.07596e-05	0	0
KIAA2018	205717	broad.mit.edu	37	3	113374068	113374068	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:113374068G>A	ENST00000316407.4	-	7	6871	c.6461C>T	c.(6460-6462)tCa>tTa	p.S2154L	KIAA2018_ENST00000478658.1_Missense_Mutation_p.S2154L|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	2154					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						AGATAAAATTGATCCAAATCG	0.403000													9	36					0	0	0.000442599	0	0
KLHL1	57626	broad.mit.edu	37	13	70314608	70314608	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr13:70314608C>T	ENST00000377844.4	-	8	2479	c.1720G>A	c.(1720-1722)Gat>Aat	p.D574N	KLHL1_ENST00000545028.1_Missense_Mutation_p.D381N	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	574					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CTCTGTGGATCCCACCTTTCC	0.413000													6	27					0	0	3.59834e-05	0	0
ZNF85	7639	broad.mit.edu	37	19	21116903	21116903	+	Missense_Mutation	SNP	G	G	A	rs149214151	byFrequency	TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:21116903G>A	ENST00000328178.8	+	2	190	c.77G>A	c.(76-78)cGg>cAg	p.R26Q	ZNF85_ENST00000300540.3_Missense_Mutation_p.R26Q|ZNF85_ENST00000597314.1_Missense_Mutation_p.R26Q|ZNF85_ENST00000596476.1_5'UTR|ZNF85_ENST00000345030.6_Missense_Mutation_p.R26Q	NM_001256173.1|NM_003429.4	NP_001243102.1|NP_003420.2	Q03923	ZNF85_HUMAN	zinc finger protein 85	26	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)	20						ACTGCACAGCGGAATTTATAT	0.408000													12	167					0	0	0.000151284	0	0
NPL	80896	broad.mit.edu	37	1	182787806	182787806	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:182787806C>T	ENST00000367554.3	+	7	849	c.531C>T	c.(529-531)ttC>ttT	p.F177F	NPL_ENST00000367553.1_Silent_p.F196F|NPL_ENST00000367552.2_Silent_p.F196F|NPL_ENST00000463899.1_3'UTR|NPL_ENST00000258317.2_Silent_p.F196F|NPL_ENST00000367555.1_Silent_p.F196F	NM_001200050.1	NP_001186979.1	Q9BXD5	NPL_HUMAN	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)	196					carbohydrate metabolic process	cytoplasm	N-acetylneuraminate lyase activity			breast(1)|central_nervous_system(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(1)|stomach(1)	15						AGTTTGCTTTCCTTTTTGGGG	0.453000													10	16					0	0	3.86212e-05	0	0
UCN3	114131	broad.mit.edu	37	10	5415751	5415751	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:5415751C>T	ENST00000380433.3	+	2	296	c.68C>T	c.(67-69)cCc>cTc	p.P23L		NM_053049.2	NP_444277.2	Q969E3	UCN3_HUMAN	urocortin 3	23						extracellular region	hormone activity			endometrium(1)|large_intestine(1)	2						ACAGGCCTCCCCCACAAGTTC	0.617000													8	31					0	0	0.000274275	0	0
ZMYND15	84225	broad.mit.edu	37	17	4647960	4647960	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:4647960C>T	ENST00000433935.1	+	11	1781	c.1724C>T	c.(1723-1725)tCa>tTa	p.S575L	ZMYND15_ENST00000573751.2_Missense_Mutation_p.S575L|ZMYND15_ENST00000592813.1_Missense_Mutation_p.S536L|ZMYND15_ENST00000269289.6_Missense_Mutation_p.S536L	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15	536							zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						TCCGGCATATCAGCACGGCCC	0.632000													18	29					0	0	7.07596e-05	0	0
FAM167A	83648	broad.mit.edu	37	8	11301725	11301725	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:11301725C>T	ENST00000284486.4	-	2	734	c.196G>A	c.(196-198)Gag>Aag	p.E66K	FAM167A_ENST00000528897.1_Missense_Mutation_p.E66K|FAM167A_ENST00000534308.1_Missense_Mutation_p.E66K	NM_053279.2	NP_444509.2	Q96KS9	F167A_HUMAN	family with sequence similarity 167, member A	66										breast(1)|endometrium(1)|large_intestine(4)|lung(2)|prostate(1)	9						GCCTGTGGCTCCGCAGCCGGC	0.697000													5	38					0	0	1.23904e-05	0	0
PKD1L1	168507	broad.mit.edu	37	7	47944918	47944918	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:47944918G>A	ENST00000289672.2	-	11	1577	c.1527C>T	c.(1525-1527)gtC>gtT	p.V509V		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	509	PKD 1.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TGTAGACAGAGACGGCTGTGG	0.443000													56	47					0	0	0.000147903	0	0
TENM4	26011	broad.mit.edu	37	11	78443359	78443359	+	Splice_Site	SNP	A	A	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:78443359A>G	ENST00000278550.7	-	21	3601		c.e21+1			NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		AAAGCTGGGTACCTGAATTTC	0.517000													4	50					0	0	1.23904e-05	0	0
PBLD	64081	broad.mit.edu	37	10	70044013	70044013	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:70044013C>T	ENST00000358769.2	-	10	990	c.788G>A	c.(787-789)gGa>gAa	p.G263E	PBLD_ENST00000309049.4_Missense_Mutation_p.G263E|PBLD_ENST00000336578.1_Missense_Mutation_p.G230E	NM_022129.3	NP_071412.2	P30039	PBLD_HUMAN	phenazine biosynthesis-like protein domain containing	263					biosynthetic process		isomerase activity			endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21						AAGGGAAATTCCCAGCTCTCC	0.443000													19	68					0	0	0.000375601	0	0
FAM135B	51059	broad.mit.edu	37	8	139164878	139164878	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:139164878C>T	ENST00000395297.1	-	13	2010	c.1840G>A	c.(1840-1842)Gaa>Aaa	p.E614K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	614										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GTACTTAATTCATGGAGAGTT	0.453000										HNSCC(54;0.14)			18	136					0	0	0.000132079	0	0
RGS7BP	401190	broad.mit.edu	37	5	63871668	63871668	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:63871668A>C	ENST00000334025.2	+	3	726	c.400A>C	c.(400-402)Atg>Ctg	p.M134L	RGS7BP_ENST00000508162.1_3'UTR	NM_001029875.1|NM_001271890.1|NM_001271891.1	NP_001025046.1|NP_001258819.1|NP_001258820.1	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding protein	134					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane				breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|stomach(1)	11		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		CTGCTTAGAAATGTATACCAC	0.428000													15	45					0	0	0.000422831	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144916572	144916572	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:144916572C>T	ENST00000529945.1	-	9	2711	c.2272G>A	c.(2272-2274)Gag>Aag	p.E758K	PDE4DIP_ENST00000369359.4_Missense_Mutation_p.E732K|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.E595K|PDE4DIP_ENST00000479408.2_Missense_Mutation_p.E382K|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.E595K|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.E595K|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.E758K|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.E732K|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.E595K|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.E661K			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	595					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGTCTTGCCTCCACTTCTTTG	0.423000			T	PDGFRB	MPD								185	832					0	0	0.000147903	0	0
NLRP10	338322	broad.mit.edu	37	11	7982175	7982175	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:7982175G>A	ENST00000328600.2	-	2	1145	c.984C>T	c.(982-984)ttC>ttT	p.F328F		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	328	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCTCATCCGTGAAATAGGAGC	0.502000													13	75					0	0	0.00010058	0	0
FAAH	2166	broad.mit.edu	37	1	46871413	46871413	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:46871413C>T	ENST00000243167.8	+	5	816	c.732C>T	c.(730-732)ttC>ttT	p.F244F	FAAH_ENST00000493735.1_3'UTR	NM_001441.2	NP_001432.2	O00519	FAAH1_HUMAN	fatty acid amide hydrolase	244					fatty acid catabolic process	cytoplasm|cytoskeleton|endomembrane system|integral to membrane|organelle membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid amide hydrolase activity			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	22	Acute lymphoblastic leukemia(166;0.155)				Propofol(DB00818)|Thiopental(DB00599)	GCATCCGCTTCCCCTCCTCCT	0.667000													11	37					0	0	0.000151284	0	0
LCK	3932	broad.mit.edu	37	1	32740503	32740503	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:32740503C>T	ENST00000373564.3	+	2	271	c.271C>T	c.(271-273)Ccc>Tcc	p.P91S	LCK_ENST00000336890.5_Intron|LCK_ENST00000333070.4_Intron			P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	200	SH3.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	CTACTTTCTCCCCGGTCTTGC	0.612000			T	TRB@	T-ALL								4	15					0	0	0.00024832	0	0
L1CAM	3897	broad.mit.edu	37	X	153133825	153133825	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:153133825G>A	ENST00000370060.1	-	14	1824	c.1635C>T	c.(1633-1635)ccC>ccT	p.P545P	L1CAM_ENST00000361981.3_Silent_p.P540P|L1CAM_ENST00000361699.4_Silent_p.P545P|L1CAM_ENST00000543994.1_Silent_p.P547P|L1CAM_ENST00000370057.3_Silent_p.P545P|L1CAM_ENST00000370055.1_Silent_p.P540P|L1CAM_ENST00000538883.1_Silent_p.P547P	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	545	Ig-like C2-type 6.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCTGCAAGGAGGGGTCAAAGG	0.597000													24	38					0	0	0.000227799	0	0
TENM1	10178	broad.mit.edu	37	X	123775834	123775834	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:123775834G>A	ENST00000422452.2	-	11	1947	c.1884C>T	c.(1882-1884)tgC>tgT	p.C628C	TENM1_ENST00000371130.3_Silent_p.C628C	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TTGGGTCTAGGCAGTCCTCTG	0.453000													25	42					0	0	9.22233e-05	0	0
MALAT1	378938	broad.mit.edu	37	11	65267942	65267942	+	RNA	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:65267942T>A	ENST00000534336.1	+	0	2710					NR_002819.2																						CAGTGTTTGATGAAGCTAGGA	0.493000													6	69					0	0	8.12818e-05	0	0
CHL1	10752	broad.mit.edu	37	3	367644	367644	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:367644C>T	ENST00000256509.2	+	4	736	c.94C>T	c.(94-96)Caa>Taa	p.Q32*	CHL1_ENST00000397491.2_Nonsense_Mutation_p.Q32*	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	32					axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		ATATTTAGTTCAACAGGTTCC	0.323000													5	14					0	0	3.59834e-05	0	0
SCAND3	114821	broad.mit.edu	37	6	28539813	28539813	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:28539813T>C	ENST00000452236.2	-	4	4470	c.3853A>G	c.(3853-3855)Agt>Ggt	p.S1285G		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1285					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ttaataacacttaaagtagag	0.348000													15	35					0	0	0.000422831	0	0
FAM83F	113828	broad.mit.edu	37	22	40425519	40425519	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:40425519G>A	ENST00000333407.5	+	5	1547		c.e5-1		FAM83F_ENST00000473717.1_Splice_Site	NM_138435.2	NP_612444.2	Q8NEG4	FA83F_HUMAN	family with sequence similarity 83, member F											breast(1)|endometrium(2)|large_intestine(1)|lung(4)|skin(4)|urinary_tract(2)	14						TGCCTCTGCAGGTAAAACAAG	0.567000													5	18					0	0	8.12818e-05	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1811260	1811260	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:1811260C>T	ENST00000250894.4	+	13	1647	c.1490C>T	c.(1489-1491)cCc>cTc	p.P497L	MAPK8IP3_ENST00000356010.5_Missense_Mutation_p.P491L	NM_015133.3	NP_055948.2	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting protein 3	497					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	42						CGCCGTGAACCCAAAGAAGAG	0.582000													14	67					0	0	7.07596e-05	0	0
TKTL1	8277	broad.mit.edu	37	X	153555954	153555954	+	Silent	SNP	C	C	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:153555954C>A	ENST00000369915.3	+	11	1608	c.1419C>A	c.(1417-1419)gtC>gtA	p.V473V	TKTL1_ENST00000217905.7_Silent_p.V213V|TKTL1_ENST00000369912.2_Silent_p.V417V|TKTL1_ENST00000482044.1_3'UTR	NM_001145933.1|NM_012253.3	NP_001139405.1|NP_036385.3	P51854	TKTL1_HUMAN	transketolase-like 1	473					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			NS(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(5)|prostate(1)|skin(1)|urinary_tract(2)	34	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCACTGTGTCAGTGACAAGG	0.483000													18	63					6.94344e-10	1.4569e-08	7.07596e-05	1	0
AIM1	202	broad.mit.edu	37	6	106969113	106969113	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:106969113G>A	ENST00000369066.3	+	2	3293	c.2806G>A	c.(2806-2808)Gat>Aat	p.D936N		NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	936							sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AGAAGATCTGGATTCACGAAG	0.363000													16	41					0	0	0.000308642	0	0
OLFM3	118427	broad.mit.edu	37	1	102312496	102312496	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:102312496G>A	ENST00000338858.5	-	1	33	c.34C>T	c.(34-36)Ctt>Ttt	p.L12F	OLFM3_ENST00000462354.1_Intron|OLFM3_ENST00000359814.3_Missense_Mutation_p.L12F|OLFM3_ENST00000370103.4_Intron			Q96PB7	NOE3_HUMAN	olfactomedin 3	12						extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		ATGGTACTAAGCACAGCGCCA	0.532000													14	61					0	0	7.07596e-05	0	0
PLCB3	5331	broad.mit.edu	37	11	64024120	64024120	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:64024120A>G	ENST00000540288.1	+	10	999	c.896A>G	c.(895-897)tAc>tGc	p.Y299C	PLCB3_ENST00000279230.6_Missense_Mutation_p.Y299C|PLCB3_ENST00000325234.5_Missense_Mutation_p.Y232C	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	299					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						TTTAGCCGCTACCTGGGAGGC	0.632000													7	23					0	0	0.000274275	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57069397	57069397	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:57069397G>A	ENST00000532437.1	-	8	5166	c.4855C>T	c.(4855-4857)Cca>Tca	p.P1619S	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.P1619S			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1619	Arg/Glu/Lys-rich (charged).				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				TCTGAAGATGGCACCCGAGAT	0.597000													9	24					0	0	0.000274275	0	0
CNTN5	53942	broad.mit.edu	37	11	100169974	100169974	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:100169974G>A	ENST00000524871.1	+	20	2756	c.2466G>A	c.(2464-2466)aaG>aaA	p.K822K	CNTN5_ENST00000528682.1_Silent_p.K822K|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000527185.1_Silent_p.K822K|CNTN5_ENST00000418526.2_Silent_p.K748K|CNTN5_ENST00000279463.3_Silent_p.K822K	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	822	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GTGGCTGGAAGGAAAAAATGG	0.408000													4	6					0	0	0.00024832	0	0
NPAP1	23742	broad.mit.edu	37	15	24924379	24924379	+	Missense_Mutation	SNP	G	G	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:24924379G>C	ENST00000329468.2	+	1	3839	c.3365G>C	c.(3364-3366)tGc>tCc	p.C1122S		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TTTCAACAGTGCATCCTGCAG	0.473000													23	81					0	0	0.00047179	0	0
RADIL	55698	broad.mit.edu	37	7	4917258	4917258	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:4917258C>T	ENST00000399583.3	-	2	700	c.513G>A	c.(511-513)aaG>aaA	p.K171K	RADIL_ENST00000536091.1_Silent_p.K171K	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	171					cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		TGTCCACCTCCTTGGCTGCCA	0.602000													29	40					0	0	0.000491102	0	0
WDR35	57539	broad.mit.edu	37	2	20173356	20173356	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:20173356T>C	ENST00000345530.3	-	8	965	c.850A>G	c.(850-852)Aac>Gac	p.N284D	WDR35_ENST00000416055.2_5'UTR|WDR35_ENST00000281405.4_Missense_Mutation_p.N284D	NM_001006657.1	NP_001006658.1	Q9P2L0	WDR35_HUMAN	WD repeat domain 35	284										breast(1)|endometrium(5)|kidney(8)|large_intestine(8)|lung(16)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCACAATGTTCACATCTTTG	0.443000													41	28					0	0	0.000106405	0	0
KIAA1324	57535	broad.mit.edu	37	1	109714493	109714493	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:109714493A>G	ENST00000369939.3	+	4	656	c.473A>G	c.(472-474)aAg>aGg	p.K158R	KIAA1324_ENST00000529753.1_Missense_Mutation_p.K158R	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	158					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		CACAGGTCCAAGTGGGTTCCC	0.567000													20	216					0	0	0.000175454	0	0
APOL3	80833	broad.mit.edu	37	22	36537413	36537413	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:36537413G>A	ENST00000424878.2	-	4	2592	c.444C>T	c.(442-444)ttC>ttT	p.F148F	APOL3_ENST00000361710.2_Silent_p.F148F|APOL3_ENST00000397293.2_Silent_p.F277F|APOL3_ENST00000397287.2_Silent_p.F148F|APOL3_ENST00000349314.2_Silent_p.F348F			O95236	APOL3_HUMAN	apolipoprotein L, 3	348					inflammatory response|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	lipid binding|lipid transporter activity|signal transducer activity			endometrium(2)|large_intestine(1)|lung(1)|stomach(1)	5						CCAGTGCAAGGAAGATGCCTG	0.582000													17	80					0	0	0.000132079	0	0
EMC2	9694	broad.mit.edu	37	8	109489041	109489041	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:109489041C>T	ENST00000220853.3	+	9	657	c.622C>T	c.(622-624)Ctc>Ttc	p.L208F	EMC2_ENST00000520294.1_3'UTR	NM_014673.3	NP_055488.1			ER membrane protein complex subunit 2																		ACTTGAAAACCTCGAACTTTC	0.338000													7	25					0	0	8.12818e-05	0	0
GIMAP7	168537	broad.mit.edu	37	7	150217799	150217799	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:150217799A>C	ENST00000313543.4	+	2	894	c.737A>C	c.(736-738)aAg>aCg	p.K246T		NM_153236.3	NP_694968.1	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	246							GTP binding			breast(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	17			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAGGAAGAAAAGGAGAAAGaa	0.269000													9	35					0	0	0.000274275	0	0
TBC1D5	9779	broad.mit.edu	37	3	17300077	17300077	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:17300077G>A	ENST00000253692.7	-	16	2916	c.1252C>T	c.(1252-1254)Cca>Tca	p.P418S	TBC1D5_ENST00000429383.4_Missense_Mutation_p.P418S|TBC1D5_ENST00000446818.2_Missense_Mutation_p.P418S|TBC1D5_ENST00000429924.2_Missense_Mutation_p.P370S|TBC1D5_ENST00000414318.2_5'UTR	NM_014744.2	NP_055559.1	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5	418						intracellular	protein binding|Rab GTPase activator activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	36						ACTGGTCTTGGATTTCTCTAA	0.318000													105	81					0	0	0.000147903	0	0
TGFBR1	7046	broad.mit.edu	37	9	101907069	101907069	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:101907069G>A	ENST00000374994.4	+	6	1146	c.1029G>A	c.(1027-1029)aaG>aaA	p.K343K	TGFBR1_ENST00000552516.1_Silent_p.K347K|TGFBR1_ENST00000550253.1_Silent_p.K274K|TGFBR1_ENST00000374990.2_Silent_p.K266K	NM_004612.2	NP_004603.1	P36897	TGFR1_HUMAN	transforming growth factor, beta receptor 1	343	Protein kinase.				activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	27		Acute lymphoblastic leukemia(62;0.0559)				TGGTAAAGAAGAATGGAACTT	0.368000													20	41					0	0	0.000132079	0	0
OR10A4	283297	broad.mit.edu	37	11	6898300	6898300	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:6898300C>T	ENST00000379829.2	+	1	445	c.422C>T	c.(421-423)tCc>tTc	p.S141F		NM_207186.2	NP_997069.2	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A, member 4	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GGCCACATATCCTGTGCCCAG	0.562000													8	16					0	0	0.000442599	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54925079	54925079	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:54925079G>A	ENST00000293373.6	+	23	2621	c.2542G>A	c.(2542-2544)Ggc>Agc	p.G848S	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.G798S	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	848					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						GGGCCCCTATGGCATGAAGTT	0.512000													26	145					0	0	0.000491102	0	0
PPP4R4	57718	broad.mit.edu	37	14	94741753	94741753	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:94741753C>T	ENST00000304338.3	+	24	2646	c.2492C>T	c.(2491-2493)tCc>tTc	p.S831F		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	831						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						GTTCCATCTTCCTTTTCTCCT	0.438000													12	51					0	0	0.000219431	0	0
HCN1	348980	broad.mit.edu	37	5	45267329	45267329	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:45267329G>A	ENST00000303230.4	-	7	1702	c.1645C>T	c.(1645-1647)Cgt>Tgt	p.R549C		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	549						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CTGGCAGTACGACGTCCTTTG	0.408000													18	86					0	0	0.000132079	0	0
RASGRF1	5923	broad.mit.edu	37	15	79265721	79265721	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:79265721G>A	ENST00000419573.3	-	26	3858	c.3584C>T	c.(3583-3585)aCc>aTc	p.T1195I	RASGRF1_ENST00000394745.3_Missense_Mutation_p.T411I|RASGRF1_ENST00000558480.2_Missense_Mutation_p.T1179I	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	1197	Ras-GEF.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GGCCAGGTCGGTGAGGTACAT	0.527000													8	40					0	0	0.000274275	0	0
EPHX4	253152	broad.mit.edu	37	1	92528792	92528792	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:92528792G>A	ENST00000370383.4	+	7	1136	c.1038G>A	c.(1036-1038)gtG>gtA	p.V346V		NM_173567.4	NP_775838.3	Q8IUS5	EPHX4_HUMAN	epoxide hydrolase 4	346						integral to membrane	hydrolase activity	p.V346V(1)		central_nervous_system(1)|large_intestine(3)|lung(8)	12						CTGACATAGTGAACAAATTGA	0.318000													23	82					0	0	9.22233e-05	0	0
HEMGN	55363	broad.mit.edu	37	9	100693459	100693459	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:100693459C>T	ENST00000259456.3	-	4	361	c.218G>A	c.(217-219)cGa>cAa	p.R73Q		NM_018437.3|NM_197978.2	NP_060907.2|NP_932095.1	Q9BXL5	HEMGN_HUMAN	hemogen	73	Necessary for nuclear localization.				cell differentiation|multicellular organismal development			p.R73Q(1)		NS(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|skin(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(62;0.0559)				TCTGCCTCTTCGATTTCCTTT	0.413000													54	65					0	0	0.000147903	0	0
IL7R	3575	broad.mit.edu	37	5	35875642	35875642	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:35875642C>T	ENST00000303115.3	+	7	958	c.829C>T	c.(829-831)Ccc>Tcc	p.P277S	IL7R_ENST00000506850.1_Silent_p.S245S|IL7R_ENST00000343305.4_Silent_p.S245S	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	277					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GCCCAGTCTCCCCGATCATAA	0.438000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						25	22					0	0	0.000227799	0	0
ASMT	438	broad.mit.edu	37	X	1746618	1746618	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:1746618G>A	ENST00000381241.3	+	4	596	c.397G>A	c.(397-399)Gag>Aag	p.E133K	ASMT_ENST00000381229.4_Missense_Mutation_p.E133K|ASMT_ENST00000381233.3_Missense_Mutation_p.E133K	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	133					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCAGTACCTGGAGACGTTTGG	0.368000													55	168					0	0	0.000147903	0	0
BMP2	650	broad.mit.edu	37	20	6759494	6759494	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:6759494C>T	ENST00000378827.4	+	3	2168	c.949C>T	c.(949-951)Ccc>Tcc	p.P317S		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	317					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	GATTGTGGCTCCCCCGGGGTA	0.512000													10	47					0	0	6.40141e-05	0	0
ELAVL2	1993	broad.mit.edu	37	9	23692855	23692855	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:23692855C>T	ENST00000397312.2	-	7	1054	c.780G>A	c.(778-780)atG>atA	p.M260I	ELAVL2_ENST00000380117.1_Missense_Mutation_p.M260I|ELAVL2_ENST00000223951.6_Missense_Mutation_p.M247I|ELAVL2_ENST00000544538.1_Missense_Mutation_p.M260I|ELAVL2_ENST00000380110.4_Missense_Mutation_p.M290I	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	260					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		CCAAACTGGTCATTCCGTCAA	0.433000													9	28					0	0	0.000442599	0	0
RGL4	266747	broad.mit.edu	37	22	24034999	24034999	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:24034999G>A	ENST00000290691.5	+	3	1687	c.517G>A	c.(517-519)Ggg>Agg	p.G173R	GUSBP11_ENST00000417194.1_RNA|RGL4_ENST00000401461.1_Missense_Mutation_p.G37R	NM_153615.1	NP_705843.1	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation stimulator-like 4	173	Pro-rich.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(3)	15						TTCAGCACCAGGGCCAGCACC	0.647000											OREG0007113	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=Rgr|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	38	32					0	0	0.000509022	0	0
SOX6	55553	broad.mit.edu	37	11	15994523	15994523	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:15994523G>A	ENST00000352083.6	-	16	2396	c.2319C>T	c.(2317-2319)ctC>ctT	p.L773L	SOX6_ENST00000528429.1_Silent_p.L773L|SOX6_ENST00000528252.1_Silent_p.L746L|SOX6_ENST00000316399.6_Silent_p.L753L|SOX6_ENST00000396356.3_Silent_p.L753L|SOX6_ENST00000527619.1_Silent_p.L749L			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	773					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						GGATGACCGGGAGGCTGGGCT	0.507000													20	26					0	0	0.00047179	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307161	39307161	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:39307161C>T	ENST00000541347.1	-	2	1079	c.840G>A	c.(838-840)acG>acA	p.T280T	CX3CR1_ENST00000399220.2_Silent_p.T280T|CX3CR1_ENST00000358309.3_Silent_p.T312T|CX3CR1_ENST00000542107.1_Silent_p.T280T	NM_001171171.1	NP_001164642.1	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	280			T -> M (common polymorphism in Caucasian population; dbSNP:rs3732378).		cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		TAAATGCAACCGTCTCAGTCA	0.473000													41	78					0	0	0.000147903	0	0
ADCY1	107	broad.mit.edu	37	7	45725619	45725619	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:45725619C>T	ENST00000297323.7	+	13	2154	c.2132C>T	c.(2131-2133)tCg>tTg	p.S711L		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	711					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	GTGGTCCTTTCGTCTGGGGGC	0.657000													16	16					0	0	0.000422831	0	0
SLC22A6	9356	broad.mit.edu	37	11	62748549	62748549	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:62748549C>T	ENST00000377871.3	-	6	1211	c.945G>A	c.(943-945)aaG>aaA	p.K315K	SLC22A6_ENST00000360421.4_Silent_p.K315K|SLC22A6_ENST00000537349.1_5'UTR|SLC22A6_ENST00000421062.2_Silent_p.K315K|SLC22A6_ENST00000458333.2_Silent_p.K315K	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	315					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						TGGTCAGCTCCTTCTGCAGAC	0.652000													4	27					0	0	0.00024832	0	0
COL6A6	131873	broad.mit.edu	37	3	130284128	130284128	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:130284128G>A	ENST00000358511.6	+	3	983	c.952G>A	c.(952-954)Gaa>Aaa	p.E318K	COL6A6_ENST00000453409.2_Missense_Mutation_p.E318K	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	318	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GCTCAGGAAGGAAGTTTTTAG	0.507000													12	69					0	0	6.40141e-05	0	0
EGF	1950	broad.mit.edu	37	4	110865147	110865147	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:110865147A>G	ENST00000265171.5	+	4	1104	c.659A>G	c.(658-660)aAc>aGc	p.N220S	EGF_ENST00000509793.1_Missense_Mutation_p.N220S|EGF_ENST00000503392.1_Missense_Mutation_p.N220S	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	220					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	ATTCAGTACAACAGAGAAGGA	0.413000													29	38					0	0	0.000147802	0	0
LYVE1	10894	broad.mit.edu	37	11	10585914	10585914	+	Silent	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:10585914G>T	ENST00000256178.3	-	2	251	c.93C>A	c.(91-93)tcC>tcA	p.S31S	MRVI1-AS1_ENST00000529829.1_RNA|LYVE1_ENST00000531706.1_Intron|MRVI1-AS1_ENST00000529979.1_RNA|LYVE1_ENST00000529598.1_Intron	NM_006691.3	NP_006682.2	Q9Y5Y7	LYVE1_HUMAN	lymphatic vessel endothelial hyaluronan receptor 1	31					anatomical structure morphogenesis|cell-matrix adhesion|cellular component movement|response to wounding|transport	integral to plasma membrane|membrane fraction				central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	8				all cancers(16;7.22e-08)|Epithelial(150;1.03e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0609)		ACACCTGGATGGAAAGCTCTG	0.507000													5	33					2.7689e-08	5.78588e-07	8.12818e-05	1	0
MBD5	55777	broad.mit.edu	37	2	149247902	149247902	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:149247902C>T	ENST00000407073.1	+	12	4999	c.4002C>T	c.(4000-4002)atC>atT	p.I1334I	MBD5_ENST00000404807.1_Silent_p.I1567I	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1334						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		AAGACTACATCCATTACAATG	0.443000													13	26					0	0	0.000151284	0	0
ASTN2	23245	broad.mit.edu	37	9	119567924	119567924	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:119567924G>A	ENST00000313400.4	-	13	2483	c.2383C>T	c.(2383-2385)Cag>Tag	p.Q795*	ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Nonsense_Mutation_p.Q744*|ASTN2_ENST00000373996.3_Nonsense_Mutation_p.Q791*			O75129	ASTN2_HUMAN	astrotactin 2	795						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						AAGGTCATCTGGAAGACTTGG	0.488000													17	53					0	0	9.7654e-05	0	0
DNAH1	25981	broad.mit.edu	37	3	52361988	52361988	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:52361988C>T	ENST00000420323.2	+	6	1090	c.829C>T	c.(829-831)Ccg>Tcg	p.P277S		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	277	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GAAACCTGTCCCGGGAAAAGC	0.552000													8	16					0	0	0.000274275	0	0
CDH6	1004	broad.mit.edu	37	5	31267592	31267592	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:31267592C>T	ENST00000265071.2	+	2	277	c.12C>T	c.(10-12)taC>taT	p.Y4Y	CDH6_ENST00000514738.1_5'UTR|RP11-152K4.2_ENST00000523584.1_RNA	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	4					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TGAGAACTTACCGCTACTTCT	0.532000													13	41					0	0	0.000308642	0	0
PLCB4	5332	broad.mit.edu	37	20	9388582	9388582	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:9388582G>A	ENST00000378501.2	+	18	1645	c.1630G>A	c.(1630-1632)Gat>Aat	p.D544N	PLCB4_ENST00000414679.2_Missense_Mutation_p.D556N|PLCB4_ENST00000334005.3_Missense_Mutation_p.D544N|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000378493.1_Missense_Mutation_p.D544N|PLCB4_ENST00000378473.3_Missense_Mutation_p.D556N|PLCB4_ENST00000278655.4_Missense_Mutation_p.D544N	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	544					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						CACTGTAGAAGATGAGCAGGC	0.428000													18	84					0	0	0.000229342	0	0
SPDEF	25803	broad.mit.edu	37	6	34512073	34512073	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:34512073C>T	ENST00000374037.3	-	2	574	c.160G>A	c.(160-162)Ggc>Agc	p.G54S	SPDEF_ENST00000544425.1_Missense_Mutation_p.G54S	NM_012391.2	NP_036523.1	O95238	SPDEF_HUMAN	SAM pointed domain containing ETS transcription factor	54					negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)	15						GCGGACAGGCCCTGCTCGGGC	0.682000													6	50					0	0	0.000442599	0	0
C9orf84	158401	broad.mit.edu	37	9	114449059	114449059	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:114449059C>T	ENST00000394779.3	-	24	4453	c.4209G>A	c.(4207-4209)agG>agA	p.R1403R	C9orf84_ENST00000318737.4_Silent_p.R1442R|C9orf84_ENST00000394777.4_Silent_p.R1368R|C9orf84_ENST00000374287.3_Silent_p.R1442R	NM_001080551.1	NP_001074020.1	Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	1442										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TTCAAAAAAACCTCAGCCGAG	0.388000													20	79					0	0	0.000375601	0	0
OR8U1	219417	broad.mit.edu	37	11	56143797	56143797	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:56143797G>A	ENST00000302270.1	+	1	698	c.698G>A	c.(697-699)gGa>gAa	p.G233E		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1									p.G233V(1)		NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					TCAGCTGAGGGAAGACAGAAG	0.463000													5	29					0	0	8.12818e-05	0	0
SELE	6401	broad.mit.edu	37	1	169695945	169695945	+	Missense_Mutation	SNP	G	G	A	rs3917429	byFrequency	TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:169695945G>A	ENST00000333360.7	-	11	1787	c.1648C>T	c.(1648-1650)Ccc>Tcc	p.P550S	C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367781.4_Missense_Mutation_p.P487S|SELE_ENST00000367780.4_Missense_Mutation_p.P425S|SELE_ENST00000367777.1_Missense_Mutation_p.P487S|SELE_ENST00000367775.1_Missense_Mutation_p.P425S|SELE_ENST00000367774.1_Missense_Mutation_p.P424S|SELE_ENST00000367776.1_Missense_Mutation_p.P487S|SELE_ENST00000367782.4_Missense_Mutation_p.P487S|SELE_ENST00000367779.4_Missense_Mutation_p.P424S	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	550			P -> S (in dbSNP:rs3917429).		actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					GACTCAGTGGGAGCTAAGGAA	0.463000													8	10					0	0	0.000274275	0	0
FOXI1	2299	broad.mit.edu	37	5	169533060	169533060	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:169533060G>A	ENST00000449804.2	+	1	144	c.99G>A	c.(97-99)gaG>gaA	p.E33E	FOXI1_ENST00000306268.6_Silent_p.E33E	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	33	Pro-rich.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding	p.E33D(1)		breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTACTATGAGAACTTCTTCC	0.677000									Pendred syndrome				4	30					0	0	3.59834e-05	0	0
ADCK4	79934	broad.mit.edu	37	19	41198219	41198219	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:41198219C>T	ENST00000324464.3	-	15	1657	c.1356G>A	c.(1354-1356)caG>caA	p.Q452Q	ADCK4_ENST00000243583.6_Silent_p.Q411Q|ADCK4_ENST00000450541.1_Silent_p.Q411Q	NM_024876.3	NP_079152.3	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4	452						integral to membrane	protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(6)|stomach(2)|urinary_tract(1)	17			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			CATAAGGGCCCTGGGTGGCGA	0.672000													4	23					0	0	8.12818e-05	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120312852	120312852	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:120312852T>C	ENST00000397843.2	+	15	1409	c.1243T>C	c.(1243-1245)Tcc>Ccc	p.S415P	ARHGEF12_ENST00000356641.3_Missense_Mutation_p.S396P|ARHGEF12_ENST00000532993.1_Missense_Mutation_p.S312P	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	415	RGSL.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		ACATACCAATTCCAAAGAAAC	0.358000			T	MLL	AML								10	25					0	0	0.00010058	0	0
SULF2	55959	broad.mit.edu	37	20	46307506	46307506	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:46307506G>A	ENST00000359930.4	-	8	1958	c.1107C>T	c.(1105-1107)atC>atT	p.I369I	SULF2_ENST00000467815.1_Silent_p.I369I|SULF2_ENST00000484875.1_Silent_p.I369I|CTD-2653D5.1_ENST00000526566.2_RNA|SULF2_ENST00000361612.4_Silent_p.I369I	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	369					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						CAATGTCCAGGATGGTGGGGG	0.617000													43	86					0	0	0.000147903	0	0
MAP2	4133	broad.mit.edu	37	2	210518038	210518038	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:210518038C>T	ENST00000360351.4	+	4	650	c.144C>T	c.(142-144)ttC>ttT	p.F48F	MAP2_ENST00000361559.4_Silent_p.F48F|MAP2_ENST00000392194.1_Silent_p.F48F|MAP2_ENST00000447185.1_Silent_p.F48F|MAP2_ENST00000199940.6_Silent_p.F48F	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	48					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CCAATGGATTCCCATACAGGG	0.537000													8	11					0	0	0.000442599	0	0
TAGAP	117289	broad.mit.edu	37	6	159458044	159458044	+	Silent	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:159458044G>T	ENST00000367066.3	-	10	1342	c.1011C>A	c.(1009-1011)gcC>gcA	p.A337A	RP1-111C20.4_ENST00000606466.1_RNA|TAGAP_ENST00000326965.6_Silent_p.A159A|RP1-111C20.4_ENST00000606470.1_RNA|RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000607391.1_RNA	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	337					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CAGCAGCTGTGGCCATGGGCA	0.627000													11	61					1.5842e-08	3.31376e-07	0.000151284	1	0
SAMD9	54809	broad.mit.edu	37	7	92735364	92735364	+	Missense_Mutation	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:92735364T>A	ENST00000379958.2	-	3	316	c.47A>T	c.(46-48)aAa>aTa	p.K16I		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	16	SAM.					cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TACATCCTCTTTTGTCCAATC	0.318000													38	145					0	0	0.000106405	0	0
COL1A2	1278	broad.mit.edu	37	7	94038674	94038674	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:94038674C>T	ENST00000297268.6	+	17	1304	c.833C>T	c.(832-834)cCc>cTc	p.P278L		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	278					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCTGCTGGTCCCGCCGGTCCC	0.468000										HNSCC(75;0.22)			69	66					0	0	0.000147903	0	0
SYT7	9066	broad.mit.edu	37	11	61300491	61300491	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:61300491G>A	ENST00000263846.4	-	4	648	c.321C>T	c.(319-321)ctC>ctT	p.L107L	SYT7_ENST00000535826.1_Silent_p.L226L|SYT7_ENST00000539008.1_Silent_p.L390L|SYT7_ENST00000540831.1_5'UTR|SYT7_ENST00000542836.1_Silent_p.L151L|SYT7_ENST00000542670.1_Silent_p.L315L|SYT7_ENST00000540677.1_Silent_p.L182L	NM_004200.3	NP_004191.2	O43581	SYT7_HUMAN	synaptotagmin VII	107						cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			kidney(2)|large_intestine(3)|lung(4)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						GGGAGTTGACGAGGTCTGAGA	0.647000													12	63					0	0	0.000219431	0	0
DCTN4	51164	broad.mit.edu	37	5	150112977	150112977	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:150112977G>A	ENST00000447998.2	-	5	605	c.490C>T	c.(490-492)Cgc>Tgc	p.R164C	DCTN4_ENST00000424236.1_Missense_Mutation_p.R107C|DCTN4_ENST00000521093.1_5'UTR|DCTN4_ENST00000446090.2_Missense_Mutation_p.R164C	NM_016221.3	NP_057305.1	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62)	164						centrosome|nucleus	protein N-terminus binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	10		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGTTTCTTGCGATCTCGCTCA	0.398000													27	94					0	0	8.91981e-05	0	0
TTLL6	284076	broad.mit.edu	37	17	46865189	46865189	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:46865189G>A	ENST00000393382.3	-	11	1714	c.1573C>T	c.(1573-1575)Cgg>Tgg	p.R525W	TTLL6_ENST00000433608.2_Missense_Mutation_p.R218W	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	477						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						TACTCCTCCCGAGCCCTGGAA	0.532000													27	46					0	0	0.000339439	0	0
TRIB2	28951	broad.mit.edu	37	2	12863439	12863439	+	Silent	SNP	T	T	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:12863439T>C	ENST00000155926.4	+	2	1743	c.324T>C	c.(322-324)tcT>tcC	p.S108S	TRIB2_ENST00000405331.3_Silent_p.S108S|TRIB2_ENST00000381465.2_5'UTR	NM_021643.3	NP_067675.1	Q92519	TRIB2_HUMAN	tribbles pseudokinase 2	108	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(5)|prostate(1)|skin(1)|stomach(1)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TTTGCCTGTCTGCTCATAGTA	0.468000													25	12					0	0	0.000117367	0	0
SNHG14	104472715	broad.mit.edu	37	15	25467413	25467413	+	RNA	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:25467413C>T	ENST00000424208.1	+	0	3147				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						CTTCCTGGTTCCCTGGTCTCT	0.602000													7	6					0	0	8.12818e-05	0	0
SCN10A	6336	broad.mit.edu	37	3	38798246	38798246	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:38798246C>T	ENST00000449082.2	-	9	1208	c.1209G>A	c.(1207-1209)caG>caA	p.Q403Q		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	403					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TTGCCTGGTTCTGCTCCTCAT	0.483000													10	144					0	0	0.000442599	0	0
PRPS1L1	221823	broad.mit.edu	37	7	18066874	18066874	+	Missense_Mutation	SNP	C	C	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:18066874C>G	ENST00000506618.2	-	1	612	c.532G>C	c.(532-534)Gtg>Ctg	p.V178L		NM_175886.2	NP_787082.1	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like 1	178					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)	18	Lung NSC(10;0.0385)|all_lung(11;0.0736)					ATGGAGGTCACTCTTTTAGCT	0.463000													39	57					0	0	0.000228196	0	0
KCNQ3	3786	broad.mit.edu	37	8	133153407	133153407	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:133153407C>T	ENST00000388996.4	-	10	1854	c.1434G>A	c.(1432-1434)atG>atA	p.M478I	KCNQ3_ENST00000521134.1_Missense_Mutation_p.M358I|KCNQ3_ENST00000519445.1_Missense_Mutation_p.M478I	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	478					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CGTAGGCTTTCATGCGGAAGG	0.478000													49	131					0	0	0.000147903	0	0
SERGEF	26297	broad.mit.edu	37	11	18017361	18017361	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:18017361C>T	ENST00000265965.5	-	6	755	c.604G>A	c.(604-606)Gaa>Aaa	p.E202K	SERGEF_ENST00000528200.1_Missense_Mutation_p.E202K|SERGEF_ENST00000532265.1_Missense_Mutation_p.E88K	NM_012139.2	NP_036271.1	Q9UGK8	SRGEF_HUMAN	secretion regulating guanine nucleotide exchange factor	202					negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|central_nervous_system(1)|large_intestine(5)|lung(5)	12						CTGCTTGGTTCCTTTGCTGTG	0.463000													5	10					0	0	1.23904e-05	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102477202	102477202	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:102477202C>T	ENST00000360184.4	+	32	6695	c.6531C>T	c.(6529-6531)gcC>gcT	p.A2177A		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2177					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						AGATGACTGCCCTTCGAGAGG	0.517000													11	71					0	0	6.40141e-05	0	0
TBC1D14	57533	broad.mit.edu	37	4	6925404	6925404	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:6925404C>T	ENST00000409757.4	+	2	412	c.288C>T	c.(286-288)atC>atT	p.I96I	TBC1D14_ENST00000448507.1_Silent_p.I96I	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	96						intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						CCGACCTCATCCCCGAGCGGG	0.672000													11	88					0	0	0.000219431	0	0
MAGI2	9863	broad.mit.edu	37	7	77807405	77807405	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:77807405C>T	ENST00000354212.4	-	14	2579	c.2326G>A	c.(2326-2328)Gaa>Aaa	p.E776K	MAGI2_ENST00000419488.1_Missense_Mutation_p.E762K|MAGI2_ENST00000522391.1_Missense_Mutation_p.E776K	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	776						cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				ACATCCAATTCCTTATAATCT	0.438000													72	36					0	0	0.000147903	0	0
ZBBX	79740	broad.mit.edu	37	3	167031813	167031813	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:167031813A>C	ENST00000392766.2	-	16	1706	c.1366T>G	c.(1366-1368)Tta>Gta	p.L456V	ZBBX_ENST00000455345.2_Missense_Mutation_p.L456V|ZBBX_ENST00000307529.5_Missense_Mutation_p.L456V|ZBBX_ENST00000392767.2_Missense_Mutation_p.L456V|ZBBX_ENST00000392764.1_Missense_Mutation_p.L427V	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	456						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						CAAAGATTTAAGAAGTCTCTC	0.313000													28	61					0	0	0.000279167	0	0
MASP1	5648	broad.mit.edu	37	3	186980348	186980348	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:186980348G>A	ENST00000337774.5	-	3	787	c.398C>T	c.(397-399)gCc>gTc	p.A133V	MASP1_ENST00000392470.2_Missense_Mutation_p.A107V|MASP1_ENST00000392472.2_Missense_Mutation_p.A20V|MASP1_ENST00000495249.1_Intron|MASP1_ENST00000296280.6_Missense_Mutation_p.A133V|MASP1_ENST00000169293.6_Missense_Mutation_p.A133V	NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	133	CUB 1.|Homodimerization (By similarity).|Interaction with FCN2.|Interaction with MBL2.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CATGTAGTGGGCATCAAAGCC	0.527000													13	18					0	0	0.000151284	0	0
TARSL2	123283	broad.mit.edu	37	15	102252163	102252163	+	Missense_Mutation	SNP	C	C	T	rs138576200		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:102252163C>T	ENST00000335968.3	-	5	948	c.732G>A	c.(730-732)atG>atA	p.M244I		NM_152334.2	NP_689547.2	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	244					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|skin(1)|urinary_tract(1)	29	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AGTAAAGCTCCATGGCCTCCC	0.458000													11	20					0	0	6.40141e-05	0	0
FAM91A1	157769	broad.mit.edu	37	8	124787428	124787428	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:124787428C>T	ENST00000334705.7	+	3	445	c.199C>T	c.(199-201)Ctg>Ttg	p.L67L	FAM91A1_ENST00000521166.1_Silent_p.L67L	NM_144963.2	NP_659400.2	Q658Y4	F91A1_HUMAN	family with sequence similarity 91, member A1	67										breast(4)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			CTATGAGGAACTGCTAAAGTA	0.363000													8	68					0	0	0.000157383	0	0
ADRB2	154	broad.mit.edu	37	5	148206853	148206853	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:148206853C>T	ENST00000305988.4	+	1	698	c.459C>T	c.(457-459)atC>atT	p.I153I		NM_000024.5	NP_000015.1	P07550	ADRB2_HUMAN	adrenoceptor beta 2, surface	153					activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(3)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	CCCGGGTGATCATTCTGATGG	0.532000													55	70					0	0	0.000147903	0	0
SCN10A	6336	broad.mit.edu	37	3	38793780	38793780	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:38793780G>A	ENST00000449082.2	-	11	1684	c.1685C>T	c.(1684-1686)tCc>tTc	p.S562F		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	562					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCCATGCCTGGAGTCAGGGTT	0.607000													10	62					0	0	3.86212e-05	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250010	140250010	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:140250010C>T	ENST00000398640.2	+	1	1322	c.1322C>T	c.(1321-1323)tCc>tTc	p.S441F	PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCAGGGTATCCGTGGAGGTG	0.637000													24	76					0	0	0.00047179	0	0
VCAN	1462	broad.mit.edu	37	5	82835754	82835754	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:82835754T>G	ENST00000265077.3	+	8	7497	c.6932T>G	c.(6931-6933)gTt>gGt	p.V2311G	VCAN_ENST00000512590.2_Intron|VCAN_ENST00000343200.5_Missense_Mutation_p.V1324G|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2311	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GCAAAAGAAGTTGGACCACTC	0.388000													7	45					0	0	0.000274275	0	0
TMEM59	9528	broad.mit.edu	37	1	54506432	54506432	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:54506432G>A	ENST00000371344.1	-	3	1730	c.311C>T	c.(310-312)tCt>tTt	p.S104F	TMEM59_ENST00000371341.1_Missense_Mutation_p.S104F|TMEM59_ENST00000371348.1_Missense_Mutation_p.S104F|TMEM59_ENST00000234831.5_Missense_Mutation_p.S235F			Q9BXS4	TMM59_HUMAN	transmembrane protein 59	235						Golgi membrane|integral to membrane				kidney(3)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7						TACATACAGAGAGAGGCATCT	0.318000													34	221					0	0	0.000159656	0	0
SAMD9	54809	broad.mit.edu	37	7	92731165	92731165	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:92731165G>A	ENST00000379958.2	-	3	4515	c.4246C>T	c.(4246-4248)Cga>Tga	p.R1416*		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1416						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			AAGACTTCTCGAAGCTGATCT	0.373000													17	175					0	0	0.000132079	0	0
CD22	933	broad.mit.edu	37	19	35832709	35832709	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:35832709C>T	ENST00000085219.5	+	9	1942	c.1876C>T	c.(1876-1878)Cac>Tac	p.H626Y	CD22_ENST00000270311.6_Missense_Mutation_p.H506Y|CD22_ENST00000544992.2_Missense_Mutation_p.H626Y|CD22_ENST00000419549.2_Missense_Mutation_p.H454Y|CD22_ENST00000536635.2_Missense_Mutation_p.H538Y|CD22_ENST00000594250.1_Missense_Mutation_p.H449Y|CD22_ENST00000341773.6_Missense_Mutation_p.H449Y	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	626	Ig-like C2-type 6.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	TCCCGTCTCCCACTACACCTG	0.607000													4	24					0	0	0.00024832	0	0
PCED1B	91523	broad.mit.edu	37	12	47629357	47629357	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:47629357G>A	ENST00000546455.1	+	4	1242	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K	PCED1B_ENST00000432328.1_Missense_Mutation_p.E171K					PC-esterase domain containing 1B																		TGTGGGCGAGGAAGTCACCGG	0.617000													14	15					0	0	0.000308642	0	0
SYT10	341359	broad.mit.edu	37	12	33529775	33529775	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:33529775G>A	ENST00000228567.3	-	7	1858	c.1562C>T	c.(1561-1563)tCc>tTc	p.S521F	SYT10_ENST00000535526.1_Missense_Mutation_p.S340F	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	521						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTATGGTGTGGAAGGTGGTTT	0.413000													18	104					0	0	0.000229342	0	0
PCSK1	5122	broad.mit.edu	37	5	95757642	95757642	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:95757642C>T	ENST00000311106.3	-	5	799	c.562G>A	c.(562-564)Gat>Aat	p.D188N	PCSK1_ENST00000508626.1_Missense_Mutation_p.D141N|CTD-2337A12.1_ENST00000502645.2_RNA	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	188	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCATTAAAATCATAGCTAGCC	0.328000													42	165					0	0	0.000125731	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52004616	52004616	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:52004616C>T	ENST00000291707.3	-	1	427	c.372G>A	c.(370-372)gaG>gaA	p.E124E		NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	124	Ig-like V-type 1.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TATTTCCTCTCTCTACACAAA	0.478000													34	67					0	0	0.000491102	0	0
PAPPA2	60676	broad.mit.edu	37	1	176664979	176664979	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:176664979C>T	ENST00000367662.3	+	7	3894	c.2730C>T	c.(2728-2730)acC>acT	p.T910T		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	910					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GTTATTGGACCCCAGAGGAGG	0.532000													11	17					0	0	0.000151284	0	0
RREB1	6239	broad.mit.edu	37	6	7231105	7231105	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:7231105C>T	ENST00000379938.2	+	10	3310	c.2773C>T	c.(2773-2775)Ctg>Ttg	p.L925L	RREB1_ENST00000379933.3_Silent_p.L925L|RREB1_ENST00000334984.6_Silent_p.L925L|RREB1_ENST00000349384.6_Silent_p.L925L	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	925					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CCCTTCTTCCCTGGTCCCCTA	0.562000													7	19					0	0	0.000157383	0	0
MPP2	4355	broad.mit.edu	37	17	41960700	41960700	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:41960700C>T	ENST00000269095.4	-	4	478	c.174G>A	c.(172-174)acG>acA	p.T58T	MPP2_ENST00000520305.1_5'UTR|MPP2_ENST00000377184.3_Silent_p.T75T|MPP2_ENST00000518766.1_Silent_p.T103T|MPP2_ENST00000536246.1_Silent_p.T47T|MPP2_ENST00000461854.1_Silent_p.T82T|MPP2_ENST00000523501.1_Silent_p.T47T|MPP2_ENST00000473246.1_5'UTR	NM_001278370.1|NM_001278381.1|NM_005374.3	NP_001265299.1|NP_001265310.1|NP_005365.3	Q14168	MPP2_HUMAN	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	82	L27 1.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|liver(1)|lung(4)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		CCTCCAGCTTCGTCTCCTCCA	0.662000													9	12					0	0	6.40141e-05	0	0
DSP	1832	broad.mit.edu	37	6	7580752	7580752	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:7580752G>A	ENST00000379802.3	+	23	4670	c.4329G>A	c.(4327-4329)agG>agA	p.R1443R	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1443	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGTCTCAGAGGAAACAGCAGC	0.498000													6	47					0	0	3.59834e-05	0	0
KRT74	121391	broad.mit.edu	37	12	52961997	52961997	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:52961997C>T	ENST00000549343.1	-	8	1391	c.1353G>A	c.(1351-1353)atG>atA	p.M451I	KRT74_ENST00000305620.2_Missense_Mutation_p.M437I			Q7RTS7	K2C74_HUMAN	keratin 74	437	Tail.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		TGGCAATCTCCATGTCCAGGG	0.642000													6	56					0	0	0.000157383	0	0
BAAT	570	broad.mit.edu	37	9	104124732	104124732	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:104124732G>A	ENST00000259407.2	-	4	1343	c.1235C>T	c.(1234-1236)cCa>cTa	p.P412L	BAAT_ENST00000395051.3_Missense_Mutation_p.P412L	NM_001127610.1|NM_001701.3	NP_001121082.1|NP_001692.1	Q14032	BAAT_HUMAN	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	412					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	GGTCACATCTGGAATGAGGTG	0.458000													11	36					0	0	0.000151284	0	0
WDR59	79726	broad.mit.edu	37	16	74946186	74946186	+	Silent	SNP	G	G	A	rs146814017		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:74946186G>A	ENST00000262144.6	-	14	1429	c.1299C>T	c.(1297-1299)ttC>ttT	p.F433F		NM_030581.3	NP_085058.3	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	433	RWD.									breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)	27						ACTGTGCAGGGAACTTCACCA	0.522000													11	48					0	0	3.86212e-05	0	0
CD180	4064	broad.mit.edu	37	5	66480226	66480226	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:66480226C>T	ENST00000256447.4	-	3	602	c.445G>A	c.(445-447)Gaa>Aaa	p.E149K		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	149					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		TCCAAGTTTTCCAGATTGTGC	0.418000													37	126					0	0	0.000374591	0	0
GPR149	344758	broad.mit.edu	37	3	154055716	154055716	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:154055716C>T	ENST00000389740.2	-	4	2067	c.1968G>A	c.(1966-1968)agG>agA	p.R656R		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	656						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGTTTTCTTTCCTGGAGTAAC	0.418000													24	74					0	0	0.000295444	0	0
SOS2	6655	broad.mit.edu	37	14	50649239	50649239	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:50649239A>C	ENST00000216373.5	-	6	1074	c.800T>G	c.(799-801)aTg>aGg	p.M267R	SOS2_ENST00000543680.1_Missense_Mutation_p.M267R	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	267	DH.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					TTCATCAGTCATTTCAACTGT	0.333000													28	53					0	0	0.000491102	0	0
LRRC37BP1	147172	broad.mit.edu	37	17	28961033	28961033	+	RNA	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:28961033T>G	ENST00000417404.1	+	0	1291				SMURF2P1_ENST00000578265.1_RNA|LRRC37BP1_ENST00000412831.1_RNA																							AGTTCCAGGATATGACTATAA	0.264000													4	125					0	0	1.23904e-05	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187692907	187692907	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:187692907C>T	ENST00000295131.2	-	9	1745	c.1706G>A	c.(1705-1707)aGa>aAa	p.R569K		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	569					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TAAAGTTGATCTCTTGTTGTC	0.368000													5	9					0	0	1.23904e-05	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965207	88965207	+	Missense_Mutation	SNP	G	G	A	rs141578416		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:88965207G>A	ENST00000333190.4	+	4	3520	c.2911G>A	c.(2911-2913)Ggc>Agc	p.G971S		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	971						intracellular	zinc ion binding	p.G971R(1)		NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TGCACCATCAGGCTGTAACAG	0.403000										HNSCC(36;0.09)			37	46					0	0	0.000509022	0	0
UBA6	55236	broad.mit.edu	37	4	68566789	68566789	+	Missense_Mutation	SNP	A	A	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:68566789A>T	ENST00000322244.4	-	1	108	c.49T>A	c.(49-51)Tgt>Agt	p.C17S	UBA6_ENST00000420827.2_Missense_Mutation_p.C17S	NM_018227.5	NP_060697.4	A0AVT1	UBA6_HUMAN	ubiquitin-like modifier activating enzyme 6	17					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						CAGGAAGAACAGGACGCCTCT	0.662000											OREG0016213	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	34					0	0	0.000157383	0	0
BRWD1	54014	broad.mit.edu	37	21	40636394	40636394	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr21:40636394A>C	ENST00000342449.3	-	17	1955	c.1877T>G	c.(1876-1878)gTg>gGg	p.V626G	BRWD1_ENST00000380800.3_Missense_Mutation_p.V626G|BRWD1_ENST00000333229.2_Missense_Mutation_p.V626G	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	626					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				ACTTGTTGCCACATAGCCCAG	0.333000													22	52					0	0	0.000229342	0	0
TTN	7273	broad.mit.edu	37	2	179552913	179552913	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:179552913C>T	ENST00000589042.1	-	127	32460	c.32236G>A	c.(32236-32238)Gaa>Aaa	p.E10746K	TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.E9502K|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E10429K|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10429	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACACACCTTCCTCCTCTTCT	0.383000													29	78					0	0	0.000339439	0	0
TSPAN8	7103	broad.mit.edu	37	12	71526510	71526510	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:71526510G>A	ENST00000393330.2	-	10	1091	c.539C>T	c.(538-540)cCa>cTa	p.P180L	TSPAN8_ENST00000552128.1_Missense_Mutation_p.P97L|TSPAN8_ENST00000546561.1_Missense_Mutation_p.P180L|TSPAN8_ENST00000247829.3_Missense_Mutation_p.P180L			P19075	TSN8_HUMAN	tetraspanin 8	180					protein glycosylation	integral to membrane|lysosome	signal transducer activity			breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(3)|lung(7)|skin(3)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			GCTTTGGCATGGTCTCTGCTT	0.353000													145	177					0	0	0.000147903	0	0
ARL3	403	broad.mit.edu	37	10	104459196	104459196	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:104459196C>T	ENST00000260746.5	-	3	329	c.198G>A	c.(196-198)tgG>tgA	p.W66*		NM_004311.3	NP_004302.1	P36405	ARL3_HUMAN	ADP-ribosylation factor-like 3	66					cell cycle|cytokinesis|small GTPase mediated signal transduction	centrosome|cytoplasmic microtubule|Golgi membrane|midbody|nucleus|photoreceptor connecting cilium|spindle microtubule	GDP binding|GTP binding|metal ion binding|microtubule binding			large_intestine(2)	2		Colorectal(252;0.122)		Epithelial(162;4.88e-09)|all cancers(201;1.29e-07)|BRCA - Breast invasive adenocarcinoma(275;0.22)		CACCAATGTCCCATACATTCA	0.338000													10	26					0	0	3.86212e-05	0	0
ZNF135	7694	broad.mit.edu	37	19	58578489	58578489	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:58578489C>T	ENST00000506786.1	+	5	1065	c.511C>T	c.(511-513)Ccc>Tcc	p.P171S	ZNF135_ENST00000439855.2_Missense_Mutation_p.P213S|ZNF135_ENST00000359978.6_Missense_Mutation_p.P225S|ZNF135_ENST00000313434.5_Missense_Mutation_p.P213S|ZNF135_ENST00000401053.4_Missense_Mutation_p.P237S|ZNF135_ENST00000511556.1_Missense_Mutation_p.P225S			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	225					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		AAAAGAGAAACCCTACAAATG	0.473000													41	44					0	0	0.000228196	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105368372	105368372	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:105368372C>T	ENST00000517991.1	+	2	860	c.848C>T	c.(847-849)tCc>tTc	p.S283F	DCSTAMP_ENST00000297581.2_Silent_p.V453V|DCSTAMP_ENST00000520080.1_3'UTR|DPYS_ENST00000521601.1_Intron	NM_001257317.1	NP_001244246.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	0					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											GGCTTCCAGTCCTGAAAATGA	0.428000													5	20					0	0	8.12818e-05	0	0
RNF214	257160	broad.mit.edu	37	11	117150966	117150966	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:117150966C>T	ENST00000530849.1	+	7	681	c.671C>T	c.(670-672)aCt>aTt	p.T224I	RNF214_ENST00000300650.4_Missense_Mutation_p.T379I|RNF214_ENST00000531452.1_Missense_Mutation_p.T379I|RNF214_ENST00000531287.1_Missense_Mutation_p.T224I			Q8ND24	RN214_HUMAN	ring finger protein 214	379							zinc ion binding			cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		TTGCACCTTACTTACCTCAAG	0.393000													19	90					0	0	0.000175454	0	0
CLCA1	1179	broad.mit.edu	37	1	86961274	86961274	+	Missense_Mutation	SNP	G	G	A	rs148962584	byFrequency	TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:86961274G>A	ENST00000234701.3	+	13	2380	c.2029G>A	c.(2029-2031)Gct>Act	p.A677T	CLCA1_ENST00000394711.1_Missense_Mutation_p.A677T			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	677					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		AAAAGTGCGGGCTCTGGGAGG	0.453000													10	36					0	0	3.86212e-05	0	0
C8A	731	broad.mit.edu	37	1	57341833	57341833	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:57341833G>A	ENST00000361249.3	+	4	511	c.415G>A	c.(415-417)Gac>Aac	p.D139N		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	139	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CATTGACGAAGACTGCAGCCA	0.522000													5	28					0	0	1.23904e-05	0	0
PWP2	5822	broad.mit.edu	37	21	45538649	45538649	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr21:45538649C>T	ENST00000291576.7	+	9	1113	c.986C>T	c.(985-987)tCa>tTa	p.S329L		NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	329						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		TGCAGCATTTCAGATCAGAGC	0.602000													7	16					0	0	0.000274275	0	0
CSHL1	1444	broad.mit.edu	37	17	61987500	61987500	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:61987500G>A	ENST00000450719.3	-	3	448	c.211C>T	c.(211-213)Ccc>Tcc	p.P71S	CSHL1_ENST00000558099.1_5'UTR|CSHL1_ENST00000259003.10_Intron|CSHL1_ENST00000438387.2_Intron|CSHL1_ENST00000392824.4_3'UTR|CSHL1_ENST00000309894.5_Intron|CSHL1_ENST00000346606.6_Intron|CSHL1_ENST00000561003.1_Missense_Mutation_p.P82S			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	0						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						CCAGGATTGGGGACCCCTGGT	0.572000													8	30					0	0	0.000442599	0	0
TENM1	10178	broad.mit.edu	37	X	123525962	123525962	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:123525962C>T	ENST00000422452.2	-	28	5691	c.5628G>A	c.(5626-5628)ggG>ggA	p.G1876G	TENM1_ENST00000371130.3_Silent_p.G1869G|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		AAATAATTTTCCCACTCTGGT	0.363000													6	35					0	0	8.12818e-05	0	0
STC2	8614	broad.mit.edu	37	5	172752981	172752981	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:172752981C>T	ENST00000265087.4	-	2	1493	c.184G>A	c.(184-186)Gat>Aat	p.D62N		NM_003714.2	NP_003705.1	O76061	STC2_HUMAN	stanniocalcin 2	62					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(3)	25	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CACCCCACATCGCCAGCGTTG	0.448000													69	151					0	0	0.000147903	0	0
KIAA0947	23379	broad.mit.edu	37	5	5461023	5461023	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:5461023G>T	ENST00000296564.7	+	13	1798	c.1576G>T	c.(1576-1578)Ggg>Tgg	p.G526W		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	526										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						AGCTGCCCCTGGGAAGTCTGA	0.453000													7	167					8.12818e-05	0.00168458	8.12818e-05	1	0
DUOXA1	90527	broad.mit.edu	37	15	45415159	45415159	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:45415159G>A	ENST00000558996.1	-	2	108	c.54C>T	c.(52-54)ttC>ttT	p.F18F	DUOXA1_ENST00000267803.4_Silent_p.F18F|DUOXA1_ENST00000430224.2_Silent_p.F18F|DUOXA1_ENST00000558422.1_Silent_p.F18F|DUOXA1_ENST00000559014.1_Silent_p.F18F|DUOXA1_ENST00000560572.1_Silent_p.F18F	NM_001276267.1|NM_001276268.1	NP_001263196.1|NP_001263197.1	Q1HG43	DOXA1_HUMAN	dual oxidase maturation factor 1	18					protein transport	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		TGTCCATCGGGAAGGTTGGCT	0.537000													5	42					0	0	3.59834e-05	0	0
GRB7	2886	broad.mit.edu	37	17	37899513	37899513	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:37899513C>T	ENST00000309156.4	+	5	801	c.544C>T	c.(544-546)Cgg>Tgg	p.R182W	GRB7_ENST00000445327.2_Missense_Mutation_p.R205W|GRB7_ENST00000309185.3_Missense_Mutation_p.R182W|GRB7_ENST00000394209.2_Missense_Mutation_p.R182W|GRB7_ENST00000394211.3_Missense_Mutation_p.R182W|GRB7_ENST00000578702.1_3'UTR|GRB7_ENST00000394204.1_Missense_Mutation_p.R182W	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	182	Ras-associating.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CTTCGTCTTCCGGAAAAACTT	0.607000													9	47					0	0	0.000274275	0	0
GRM5	2915	broad.mit.edu	37	11	88300835	88300835	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:88300835G>A	ENST00000418177.2	-	8	2383	c.2016C>T	c.(2014-2016)atC>atT	p.I672I	GRM5_ENST00000393297.1_Silent_p.I672I|GRM5_ENST00000305432.5_Silent_p.I672I|GRM5_ENST00000455756.2_Silent_p.I672I|GRM5_ENST00000305447.4_Silent_p.I672I			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	672					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TGCCAGCCAGGATCCTTGCAA	0.478000													8	33					0	0	0.000157383	0	0
COPS3	8533	broad.mit.edu	37	17	17168147	17168147	+	Missense_Mutation	SNP	T	T	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:17168147T>A	ENST00000539941.2	-	6	738	c.530A>T	c.(529-531)aAc>aTc	p.N177I	COPS3_ENST00000439936.2_Missense_Mutation_p.N177I|COPS3_ENST00000268717.5_Missense_Mutation_p.N197I	NM_001199125.1	NP_001186054.1	Q9UNS2	CSN3_HUMAN	COP9 signalosome subunit 3	197					cullin deneddylation|response to light stimulus|signal transduction	cytoplasm|signalosome	protein binding			NS(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						TCTTTCAAAGTTCTTCAGCCC	0.358000													48	32					0	0	0.000147903	0	0
OR13C8	138802	broad.mit.edu	37	9	107331487	107331487	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:107331487C>T	ENST00000335040.1	+	1	39	c.39C>T	c.(37-39)ttC>ttT	p.F13F		NM_001004483.1	NP_001004483.1	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C, member 8	13					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|skin(1)	25						CAGAATTTTTCCTGGTAGGGC	0.413000													24	86					0	0	7.16444e-05	0	0
CXorf23	256643	broad.mit.edu	37	X	19948046	19948046	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:19948046C>T	ENST00000379687.3	-	10	1909	c.1876G>A	c.(1876-1878)Ggt>Agt	p.G626S	CXorf23_ENST00000379682.4_Missense_Mutation_p.G655S|CXorf23_ENST00000356980.3_3'UTR	NM_198279.3	NP_938020.2	A2AJT9	CX023_HUMAN	chromosome X open reading frame 23	655						mitochondrion				endometrium(2)|large_intestine(1)|lung(6)|skin(1)|urinary_tract(1)	11						CATCTGCCACCTCTAAAGTTG	0.433000													43	59					0	0	0.000147903	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141025	143141025	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:143141025C>T	ENST00000332690.1	+	1	480	c.480C>T	c.(478-480)ttC>ttT	p.F160F	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	160					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					TTCTATTTTTCATAGGCAACC	0.453000													102	104					0	0	0.000147903	0	0
EPHA6	285220	broad.mit.edu	37	3	97467475	97467475	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:97467475G>A	ENST00000389672.5	+	18	3361	c.3323G>A	c.(3322-3324)cGa>cAa	p.R1108Q		NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	1013						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CACCAGAGACGAATAGTCAGC	0.428000													18	25					0	0	0.000229342	0	0
NUMB	8650	broad.mit.edu	37	14	73746042	73746042	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:73746042G>A	ENST00000556772.1	-	6	3042	c.755C>T	c.(754-756)cCt>cTt	p.P252L	NUMB_ENST00000544991.3_Intron|NUMB_ENST00000454166.4_Intron|NUMB_ENST00000535282.1_Missense_Mutation_p.P385L|NUMB_ENST00000560335.1_Intron|NUMB_ENST00000356296.4_Intron|NUMB_ENST00000559312.1_Intron|NUMB_ENST00000557597.1_Missense_Mutation_p.P385L|NUMB_ENST00000355058.3_Missense_Mutation_p.P396L|NUMB_ENST00000359560.3_Missense_Mutation_p.P385L|NUMB_ENST00000555738.2_Intron|NUMB_ENST00000555394.1_Intron|NUMB_ENST00000555238.1_Missense_Mutation_p.P396L|NUMB_ENST00000554521.2_Intron|NUMB_ENST00000554546.1_Intron			P49757	NUMB_HUMAN	numb homolog (Drosophila)	396					axon guidance|lateral ventricle development|neuroblast division in subventricular zone|positive regulation of neurogenesis	integral to plasma membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	28				BRCA - Breast invasive adenocarcinoma(234;0.00471)|OV - Ovarian serous cystadenocarcinoma(108;0.161)		ATGGGCCCAAGGGTTGGTTTC	0.537000													8	62					0	0	0.000157383	0	0
MUC16	94025	broad.mit.edu	37	19	9068327	9068327	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:9068327G>A	ENST00000397910.4	-	3	19322	c.19119C>T	c.(19117-19119)acC>acT	p.T6373T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6375	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTTCTGGGAGGTGCTAGTCT	0.453000													9	25					0	0	3.86212e-05	0	0
SLC17A2	10246	broad.mit.edu	37	6	25923937	25923937	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:25923937C>T	ENST00000377850.3	-	3	750	c.226G>A	c.(226-228)Gaa>Aaa	p.E76K	SLC17A2_ENST00000265425.3_Missense_Mutation_p.E76K|SLC17A2_ENST00000360488.3_Missense_Mutation_p.E76K			O00624	NPT3_HUMAN	solute carrier family 17, member 2	76					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	31						GTATCAAATTCCTTGATGGAT	0.433000													78	110					0	0	0.000147903	0	0
OR10A6	390093	broad.mit.edu	37	11	7950061	7950061	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:7950061G>A	ENST00000309838.2	-	1	148	c.149C>T	c.(148-150)tCc>tTc	p.S50F		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTGGTCTAGGGAGACGATGAC	0.463000													9	34					0	0	3.86212e-05	0	0
STON1	11037	broad.mit.edu	37	2	48807936	48807936	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:48807936C>T	ENST00000309835.3	+	1	174	c.164C>T	c.(163-165)tCc>tTc	p.S55F	STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.S55F|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.S55F|STON1_ENST00000406226.1_Missense_Mutation_p.S55F|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.S55F|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.S55F|STON1-GTF2A1L_ENST00000394754.1_Missense_Mutation_p.S55F|STON1_ENST00000404752.1_Missense_Mutation_p.S55F					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGTGGATCTTCCTCCACCAGC	0.468000													16	37					0	0	5.01169e-05	0	0
NPAP1	23742	broad.mit.edu	37	15	24923207	24923207	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:24923207G>A	ENST00000329468.2	+	1	2667	c.2193G>A	c.(2191-2193)ggG>ggA	p.G731G		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CTGGTTCTGGGAACACACAAC	0.537000													11	57					0	0	3.86212e-05	0	0
FAM47C	442444	broad.mit.edu	37	X	37027219	37027219	+	Missense_Mutation	SNP	C	C	T	rs148119466	byFrequency	TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:37027219C>T	ENST00000358047.3	+	1	788	c.736C>T	c.(736-738)Ctc>Ttc	p.L246F		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	246										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						AGTGTCCCATCTCCGCCCAGA	0.627000													18	5					0	0	0.000132079	0	0
TLR6	10333	broad.mit.edu	37	4	38830970	38830970	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:38830970C>T	ENST00000436693.2	-	2	244	c.125G>A	c.(124-126)gGt>gAt	p.G42D	TLR6_ENST00000381950.1_Missense_Mutation_p.G42D	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	42					activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ATGAATAAGACCTCTTTTTGA	0.393000													33	141					0	0	0.000339439	0	0
ROS1	6098	broad.mit.edu	37	6	117686903	117686903	+	Splice_Site	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:117686903C>T	ENST00000368508.3	-	19	3012	c.2812_splice	c.e19-1	p.G938_splice	ROS1_ENST00000368507.3_Splice_Site_p.G933_splice|GOPC_ENST00000467125.1_Intron	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	938					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AGGAAAAGTTCCCTACAGGAT	0.318000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								6	7					0	0	3.59834e-05	0	0
CTNND2	1501	broad.mit.edu	37	5	11364983	11364983	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:11364983G>T	ENST00000304623.8	-	8	1386	c.1197C>A	c.(1195-1197)taC>taA	p.Y399*	CTNND2_ENST00000503622.1_Nonsense_Mutation_p.Y62*|CTNND2_ENST00000359640.2_Nonsense_Mutation_p.Y399*|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_5'UTR|CTNND2_ENST00000511377.1_Nonsense_Mutation_p.Y308*	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	399					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GCTGGCTGCTGTATGAGGCTC	0.507000													12	63					3.27435e-08	6.83504e-07	0.000219431	1	0
ASXL3	80816	broad.mit.edu	37	18	31324745	31324745	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr18:31324745G>A	ENST00000269197.5	+	12	4933	c.4933G>A	c.(4933-4935)Gaa>Aaa	p.E1645K		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1645					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TATCAAAACTGAACATGCCAA	0.438000											OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	52					0	0	5.01169e-05	0	0
NLRP9	338321	broad.mit.edu	37	19	56243688	56243688	+	Silent	SNP	G	G	A	rs143748392		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:56243688G>A	ENST00000332836.2	-	2	1536	c.1509C>T	c.(1507-1509)atC>atT	p.I503I		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	503						cytoplasm	ATP binding	p.I503I(1)		NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		GCATGCTGACGATTTCTTCTG	0.433000													56	108					0	0	0.000147903	0	0
MUC16	94025	broad.mit.edu	37	19	9050038	9050038	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:9050038G>A	ENST00000397910.4	-	5	31796	c.31593C>T	c.(31591-31593)ttC>ttT	p.F10531F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10533	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAACATCAGGGAAAACATATG	0.478000													31	206					0	0	8.91981e-05	0	0
FER1L6	654463	broad.mit.edu	37	8	124987451	124987451	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:124987451C>T	ENST00000522917.1	+	8	794	c.588C>T	c.(586-588)acC>acT	p.T196T	FER1L6_ENST00000399018.1_Silent_p.T196T	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	196						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GGACTGGCACCAAGGGGTACC	0.502000													35	73					0	0	0.000228196	0	0
RIF1	55183	broad.mit.edu	37	2	152319852	152319852	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:152319852C>T	ENST00000243326.4	+	29	4301	c.3818C>T	c.(3817-3819)tCa>tTa	p.S1273L	RIF1_ENST00000453091.2_Missense_Mutation_p.S1273L|RIF1_ENST00000444746.2_Missense_Mutation_p.S1273L|RIF1_ENST00000430328.2_Missense_Mutation_p.S1273L|RIF1_ENST00000428287.2_Missense_Mutation_p.S1273L			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	1273					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		GGGACTTTTTCAAAATCTGAT	0.343000													45	123					0	0	0.000147903	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84532006	84532006	+	RNA	SNP	A	A	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:84532006A>G	ENST00000527857.1	+	0	2028					NR_026851.1																						TTGGTCAGAAAGTCTTTCAAG	0.458000													5	19					0	0	3.59834e-05	0	0
LRIT3	345193	broad.mit.edu	37	4	110791224	110791224	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:110791224G>A	ENST00000327908.3	+	4	1534	c.770G>A	c.(769-771)cGa>cAa	p.R257Q	LRIT3_ENST00000409621.2_Missense_Mutation_p.R257Q|LRIT3_ENST00000379920.3_Missense_Mutation_p.R395Q|LRIT3_ENST00000594814.1_Missense_Mutation_p.R440Q			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	395	Ig-like.					integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		GCCAACAAGCGATCATTCCAG	0.468000													13	61					0	0	0.00010058	0	0
HSD17B2	3294	broad.mit.edu	37	16	82101883	82101883	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:82101883G>A	ENST00000199936.4	+	2	567	c.374G>A	c.(373-375)cGa>cAa	p.R125Q	RP11-510J16.5_ENST00000567021.1_RNA	NM_002153.2	NP_002144.1	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	125					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10					NADH(DB00157)	GAGGAATTGCGAAGAACCTGC	0.527000													15	19					0	0	7.07596e-05	0	0
SLC9A2	6549	broad.mit.edu	37	2	103324903	103324903	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:103324903G>A	ENST00000233969.2	+	12	2536	c.2394G>A	c.(2392-2394)tcG>tcA	p.S798S		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	798						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						GGAGGGCATCGGAACCTGGAA	0.567000													12	56					0	0	0.000219431	0	0
SLC28A1	9154	broad.mit.edu	37	15	85478717	85478717	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:85478717G>A	ENST00000394573.1	+	15	1751	c.1549G>A	c.(1549-1551)Gag>Aag	p.E517K	SLC28A1_ENST00000537216.1_Missense_Mutation_p.E517K|SLC28A1_ENST00000286749.3_Missense_Mutation_p.E517K|SLC28A1_ENST00000538177.1_Intron|SLC28A1_ENST00000537624.1_Missense_Mutation_p.E517K	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	517					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGGGGCCGAGGAGTGGGTCGG	0.617000													15	120					0	0	9.7654e-05	0	0
STON1	11037	broad.mit.edu	37	2	48807961	48807961	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:48807961C>T	ENST00000309835.3	+	1	199	c.189C>T	c.(187-189)tcC>tcT	p.S63S	STON1-GTF2A1L_ENST00000394751.3_Silent_p.S63S|STON1-GTF2A1L_ENST00000309827.2_Silent_p.S63S|STON1_ENST00000406226.1_Silent_p.S63S|STON1-GTF2A1L_ENST00000405008.1_Silent_p.S63S|STON1-GTF2A1L_ENST00000402114.2_Silent_p.S63S|STON1-GTF2A1L_ENST00000394754.1_Silent_p.S63S|STON1_ENST00000404752.1_Silent_p.S63S					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CTCCTCTCTCCTCCCCCATTG	0.493000													25	52					0	0	0.000117367	0	0
SPPL2C	162540	broad.mit.edu	37	17	43923760	43923760	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:43923760G>T	ENST00000329196.5	+	1	1505	c.1488G>T	c.(1486-1488)atG>atT	p.M496I	MAPT-AS1_ENST00000579599.1_RNA|MAPT-AS1_ENST00000579244.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	496						integral to membrane	aspartic-type endopeptidase activity										TCATGCAGATGGGCCAACCTG	0.612000													47	23					2.52991e-16	5.3415e-15	0.000147903	1	0
RFC1	5981	broad.mit.edu	37	4	39301645	39301645	+	Missense_Mutation	SNP	G	G	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:39301645G>C	ENST00000381897.1	-	21	2940	c.2807C>G	c.(2806-2808)gCg>gGg	p.A936G	RFC1_ENST00000349703.2_Missense_Mutation_p.A935G	NM_001204747.1|NM_002913.4	NP_001191676.1|NP_002904.3	P35251	RFC1_HUMAN	replication factor C (activator 1) 1, 145kDa	936					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						GCTCACCTGCGCAGGCAGAAG	0.448000													13	36					0	0	0.000219431	0	0
HECW1	23072	broad.mit.edu	37	7	43548571	43548571	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:43548571G>A	ENST00000395891.1	+	24	4475	c.3870G>A	c.(3868-3870)ctG>ctA	p.L1290L	AC011738.4_ENST00000436105.1_RNA|HECW1_ENST00000453890.1_Silent_p.L1256L	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1290	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						TTTGCAGCCTGGACTACAGTG	0.527000													32	79					0	0	0.000109025	0	0
FAT1	2195	broad.mit.edu	37	4	187549677	187549677	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:187549677G>A	ENST00000441802.2	-	8	4773	c.4564C>T	c.(4564-4566)Cat>Tat	p.H1522Y		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1522	Cadherin 13.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						ACAGCTTCATGATCCAGTTTC	0.507000										HNSCC(5;0.00058)			12	41					0	0	0.000151284	0	0
STXBP5L	9515	broad.mit.edu	37	3	120876361	120876361	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:120876361C>T	ENST00000273666.6	+	9	1035	c.764C>T	c.(763-765)tCa>tTa	p.S255L	STXBP5L_ENST00000492541.1_Missense_Mutation_p.S255L|STXBP5L_ENST00000497029.1_Missense_Mutation_p.S255L|STXBP5L_ENST00000472879.1_Missense_Mutation_p.S255L|STXBP5L_ENST00000471454.1_Missense_Mutation_p.S255L	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	255					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		GCTATTCATTCAATTGATTGG	0.358000													6	40					0	0	8.12818e-05	0	0
TRDN	10345	broad.mit.edu	37	6	123824976	123824976	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:123824976C>T	ENST00000334268.4	-	8	998	c.681G>A	c.(679-681)caG>caA	p.Q227Q	TRDN_ENST00000398178.3_Silent_p.Q227Q|TRDN_ENST00000546248.1_Silent_p.Q227Q			Q13061	TRDN_HUMAN	triadin	227					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		TCACTTTCTCCTGTTTTCCAC	0.363000													4	3					0	0	0.00024832	0	0
HYDIN	54768	broad.mit.edu	37	16	71212863	71212863	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:71212863C>T	ENST00000393567.2	-	4	499	c.349G>A	c.(349-351)Gaa>Aaa	p.E117K	HYDIN_ENST00000288168.10_Missense_Mutation_p.E134K|HYDIN_ENST00000448089.2_Missense_Mutation_p.E117K|HYDIN_ENST00000538248.1_Missense_Mutation_p.E144K|HYDIN_ENST00000393550.2_Missense_Mutation_p.E117K|HYDIN_ENST00000321489.5_Missense_Mutation_p.E117K|HYDIN_ENST00000448691.1_Missense_Mutation_p.E117K|HYDIN_ENST00000541601.1_Missense_Mutation_p.E134K	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	117										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AGTGGAACTTCATAGACTTCA	0.393000													12	41					0	0	6.40141e-05	0	0
LMO2	4005	broad.mit.edu	37	11	33880940	33880940	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:33880940C>T	ENST00000257818.2	-	6	1475	c.646G>A	c.(646-648)Gac>Aac	p.D216N	LMO2_ENST00000395833.3_Missense_Mutation_p.D147N	NM_005574.3	NP_005565.2	P25791	RBTN2_HUMAN	LIM domain only 2 (rhombotin-like 1)	147					multicellular organismal development	nucleus	protein binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)|urinary_tract(1)	14						TCGTAGATGTCCTGTTCGCAC	0.502000			T	TRD@	T-ALL								25	42					0	0	0.000279167	0	0
TTN	7273	broad.mit.edu	37	2	179611340	179611340	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:179611340C>T	ENST00000360870.5	-	46	16009	c.15787G>A	c.(15787-15789)Gaa>Aaa	p.E5263K	TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8782	Ig-like 33.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTTTGCTTCCCCTATGATG	0.423000													8	9					0	0	0.000157383	0	0
ABCA3	21	broad.mit.edu	37	16	2347406	2347406	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:2347406C>T	ENST00000301732.5	-	17	2887	c.2187G>A	c.(2185-2187)ctG>ctA	p.L729L	ABCA3_ENST00000382381.3_Silent_p.L671L	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	729	ABC transporter 1.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				TGCGGTCTCCCAGCAGGTCAG	0.627000													32	25					0	0	8.91981e-05	0	0
OTOP2	92736	broad.mit.edu	37	17	72926570	72926570	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:72926570C>T	ENST00000331427.4	+	6	932	c.840C>T	c.(838-840)acC>acT	p.T280T	OTOP2_ENST00000580223.1_Silent_p.T280T	NM_178160.2	NP_835454.1	Q7RTS6	OTOP2_HUMAN	otopetrin 2	280						integral to membrane				breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|prostate(4)|skin(1)|urinary_tract(2)	39	all_lung(278;0.172)|Lung NSC(278;0.207)					ACACCCCAACCCCTGTCAGCC	0.582000													33	44					0	0	0.000132358	0	0
TEX15	56154	broad.mit.edu	37	8	30705003	30705003	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:30705003C>T	ENST00000256246.2	-	1	1605	c.1531G>A	c.(1531-1533)Gaa>Aaa	p.E511K		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	511										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CTGAAATTTTCGTTTGTATGA	0.303000													18	138					0	0	7.07596e-05	0	0
FUT9	10690	broad.mit.edu	37	6	96651968	96651968	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:96651968C>T	ENST00000302103.5	+	3	1263	c.937C>T	c.(937-939)Ctt>Ttt	p.L313F		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	313					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		TAAGTTATACCTTAGTTACTT	0.373000													8	27					0	0	0.000157383	0	0
NAP1L2	4674	broad.mit.edu	37	X	72434151	72434151	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:72434151C>T	ENST00000373517.3	-	1	533	c.178G>A	c.(178-180)Gaa>Aaa	p.E60K	NAP1L2_ENST00000536638.1_Intron	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	60					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					TCACCGTTTTCCCCTTCTTCC	0.582000													20	17					0	0	0.000175454	0	0
CRB1	23418	broad.mit.edu	37	1	197391011	197391011	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:197391011G>A	ENST00000367397.1	+	2	1054	c.196G>A	c.(196-198)Gga>Aga	p.G66R	CRB1_ENST00000538660.1_Missense_Mutation_p.G685R|CRB1_ENST00000543483.1_3'UTR|CRB1_ENST00000367399.2_Missense_Mutation_p.G573R|CRB1_ENST00000535699.1_Missense_Mutation_p.G616R|CRB1_ENST00000544212.1_Missense_Mutation_p.G166R|CRB1_ENST00000367400.3_Missense_Mutation_p.G685R			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	685	EGF-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TCAAAGCAGAGGACGCTGCAT	0.507000													6	29					0	0	3.59834e-05	0	0
PRKRIR	5612	broad.mit.edu	37	11	76063416	76063416	+	Missense_Mutation	SNP	A	A	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:76063416A>T	ENST00000260045.3	-	5	883	c.778T>A	c.(778-780)Ttt>Att	p.F260I		NM_004705.2	NP_004696.2	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	260					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	25						ATAATGGAAAAGAAGTGTGAG	0.438000													15	64					0	0	0.000422831	0	0
KAT6A	7994	broad.mit.edu	37	8	41798546	41798546	+	Silent	SNP	G	G	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:41798546G>C	ENST00000396930.3	-	16	3396	c.2853C>G	c.(2851-2853)ctC>ctG	p.L951L	KAT6A_ENST00000406337.1_Silent_p.L951L|KAT6A_ENST00000265713.2_Silent_p.L951L	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	951					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										GGCTTTTCTTGAGCTGTCCTC	0.582000													5	142					0	0	8.12818e-05	0	0
PSG7	5676	broad.mit.edu	37	19	43430822	43430822	+	RNA	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:43430822C>T	ENST00000446844.3	-	0	845				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				CCTTATTCTCCCTGGGGTTTA	0.493000													40	124					0	0	0.000125731	0	0
CYP2A6	1548	broad.mit.edu	37	19	41350627	41350627	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:41350627G>T	ENST00000301141.5	-	8	1232	c.1212C>A	c.(1210-1212)ttC>ttA	p.F404L	CTC-490E21.12_ENST00000601627.1_Intron	NM_000762.5	NP_000753.3	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 6	404					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)	37			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	GGTTGGAGAAGAAACTGGGGT	0.537000													19	35					7.21436e-19	1.52479e-17	0.000132079	1	0
CACNA1A	773	broad.mit.edu	37	19	13418659	13418659	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:13418659G>A	ENST00000360228.5	-	15	1922	c.1923C>T	c.(1921-1923)ttC>ttT	p.F641F	CACNA1A_ENST00000573710.2_Silent_p.F642F	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	642					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TCCCTTCATCGAAATTAAACC	0.547000													27	62					0	0	0.000279167	0	0
PHKA1	5255	broad.mit.edu	37	X	71877446	71877446	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:71877446G>A	ENST00000373545.3	-	9	1348	c.910C>T	c.(910-912)Cct>Tct	p.P304S	PHKA1_ENST00000541944.1_Missense_Mutation_p.P304S|PHKA1_ENST00000373542.4_Missense_Mutation_p.P304S|PHKA1_ENST00000339490.3_Missense_Mutation_p.P304S|PHKA1_ENST00000373539.3_Missense_Mutation_p.P304S			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	304					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					ACCTCTTTAGGAGTTTTATAT	0.418000													5	21					0	0	3.59834e-05	0	0
IQGAP2	10788	broad.mit.edu	37	5	75950773	75950773	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:75950773G>A	ENST00000274364.6	+	20	2562	c.2265G>A	c.(2263-2265)gtG>gtA	p.V755V	IQGAP2_ENST00000396234.3_Silent_p.V251V|IQGAP2_ENST00000379730.3_Silent_p.V257V|IQGAP2_ENST00000502745.1_Silent_p.V251V	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	755	IQ 3.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		ATGAAATTGTGAAAATACAGT	0.353000													20	94					0	0	7.16444e-05	0	0
DYNLRB1	83658	broad.mit.edu	37	20	33122618	33122618	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:33122618C>T	ENST00000417166.2	+	3	299	c.266C>T	c.(265-267)tCc>tTc	p.S89F	DYNLRB1_ENST00000480759.1_Intron|DYNLRB1_ENST00000374846.3_Intron|DYNLRB1_ENST00000357156.2_Intron			Q9NP97	DLRB1_HUMAN	dynein, light chain, roadblock-type 1	0					microtubule-based movement|transport|visual behavior	centrosome|cytoplasmic dynein complex|microtubule	microtubule motor activity			endometrium(1)|large_intestine(1)|lung(1)	3						TCTTCTACCTCCCCATGTAGG	0.532000													5	25					0	0	8.12818e-05	0	0
ARSJ	79642	broad.mit.edu	37	4	114823585	114823585	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:114823585C>T	ENST00000315366.7	-	2	2511	c.1645G>A	c.(1645-1647)Ggg>Agg	p.G549R	ARSJ_ENST00000541197.1_Missense_Mutation_p.G549R	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	549						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		CCCCAGACCCCTCCATTGAGC	0.463000													5	22					0	0	3.59834e-05	0	0
FAT4	79633	broad.mit.edu	37	4	126336764	126336764	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:126336764C>T	ENST00000394329.3	+	5	6659	c.6646C>T	c.(6646-6648)Cct>Tct	p.P2216S	FAT4_ENST00000335110.5_Missense_Mutation_p.P514S	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2216	Cadherin 21.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TGTCGCTAAACCTTTGGATAG	0.463000													6	35					0	0	8.12818e-05	0	0
NEB	4703	broad.mit.edu	37	2	152404847	152404847	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:152404847C>T	ENST00000397345.3	-	131	20334	c.20132G>A	c.(20131-20133)cGg>cAg	p.R6711Q	NEB_ENST00000172853.10_Missense_Mutation_p.R5010Q|NEB_ENST00000603639.1_Missense_Mutation_p.R6711Q|NEB_ENST00000427231.2_Missense_Mutation_p.R6711Q|NEB_ENST00000409198.1_Missense_Mutation_p.R5010Q|NEB_ENST00000604864.1_Missense_Mutation_p.R6711Q	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	5010					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTTGACTCTCCGGACGTGGAC	0.423000													40	32					0	0	0.000106405	0	0
AP4B1	10717	broad.mit.edu	37	1	114442839	114442839	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:114442839G>A	ENST00000369569.1	-	5	1081	c.801C>T	c.(799-801)ccC>ccT	p.P267P	AP4B1_ENST00000256658.4_Silent_p.P267P|AP4B1_ENST00000369566.3_Silent_p.P174P|AP4B1-AS1_ENST00000419536.1_RNA|AP4B1_ENST00000369567.1_Silent_p.P99P	NM_001253852.1	NP_001240781.1	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1 subunit	267					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|prostate(3)	25	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTGTACGTGGGGAAACATTT	0.468000													11	63					0	0	3.86212e-05	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887606	12887606	+	Missense_Mutation	SNP	C	C	G	rs58074988		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:12887606C>G	ENST00000535591.1	-	3	446	c.251G>C	c.(250-252)tGc>tCc	p.C84S		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	84								p.C84S(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						ATTGAGGAAGCACCCATGGGC	0.483000													8	341					0	0	3.86212e-05	0	0
LRP1	4035	broad.mit.edu	37	12	57590918	57590918	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:57590918G>A	ENST00000243077.3	+	56	9512	c.9046G>A	c.(9046-9048)Ggc>Agc	p.G3016S		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3016	EGF-like 12; calcium-binding (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ACCCCGCGGCGGCGACCCCCA	0.642000													23	14					0	0	0.000147802	0	0
FNDC1	84624	broad.mit.edu	37	6	159651016	159651016	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr6:159651016C>T	ENST00000297267.9	+	10	1550	c.1350C>T	c.(1348-1350)ttC>ttT	p.F450F	FNDC1_ENST00000340366.6_Intron	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	450	Fibronectin type-III 4.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CCAAAGCCTTCATTGTCGCTA	0.488000													37	141					0	0	0.000319135	0	0
DCN	1634	broad.mit.edu	37	12	91545434	91545434	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:91545434G>A	ENST00000052754.5	-	7	1383	c.882C>T	c.(880-882)atC>atT	p.I294I	DCN_ENST00000420120.2_Silent_p.I185I|DCN_ENST00000425043.1_Silent_p.I147I|DCN_ENST00000393155.1_Silent_p.I294I|DCN_ENST00000228329.5_Silent_p.I185I|DCN_ENST00000552962.1_Silent_p.I294I|DCN_ENST00000303320.3_Intron|DCN_ENST00000441303.2_Intron|DCN_ENST00000456569.2_Intron|DCN_ENST00000547568.2_Silent_p.I147I	NM_001920.3	NP_001911.1	P07585	PGS2_HUMAN	decorin	294					organ morphogenesis	extracellular space				central_nervous_system(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|skin(1)	20						GCATTACCTGGATGTACTTAT	0.502000													20	30					0	0	0.000229342	0	0
CLSTN2	64084	broad.mit.edu	37	3	140282839	140282839	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:140282839C>T	ENST00000458420.3	+	16	2709	c.2519C>T	c.(2518-2520)tCc>tTc	p.S840F		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	840					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						ATCATCATCTCCGTGTGCATG	0.537000										HNSCC(16;0.037)			23	159					0	0	0.000375601	0	0
NLRP4	147945	broad.mit.edu	37	19	56373427	56373427	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:56373427G>A	ENST00000301295.6	+	5	2510	c.2088G>A	c.(2086-2088)ttG>ttA	p.L696L	NLRP4_ENST00000346986.5_Silent_p.L696L|NLRP4_ENST00000587891.1_Silent_p.L621L	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	696							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AGCCAGACTTGAAATACCTGA	0.443000													27	144					0	0	9.22233e-05	0	0
NRXN2	9379	broad.mit.edu	37	11	64453131	64453131	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:64453131C>T	ENST00000265459.6	-	6	1600	c.1139G>A	c.(1138-1140)cGa>cAa	p.R380Q	NRXN2_ENST00000377559.3_Missense_Mutation_p.R356Q|NRXN2_ENST00000409571.1_Missense_Mutation_p.R380Q|NRXN2_ENST00000377551.1_Missense_Mutation_p.R380Q	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	380	Laminin G-like 2.				cell adhesion	integral to membrane	metal ion binding	p.R380Q(1)		breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						GCGCAGGTTTCGGGTGACCCG	0.607000													11	44					0	0	0.000151284	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8216332	8216332	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:8216332G>A	ENST00000361926.3	+	3	804	c.694G>A	c.(694-696)Gag>Aag	p.E232K	ARHGEF15_ENST00000421050.1_Missense_Mutation_p.E232K	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	232					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						GGGGGGCTATGAGGAGGTCCC	0.706000													22	44					0	0	0.000229342	0	0
DPYS	1807	broad.mit.edu	37	8	105463544	105463544	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:105463544C>T	ENST00000351513.2	-	2	485	c.353G>A	c.(352-354)cGa>cAa	p.R118Q		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	118					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AGCCCAGCTTCGCCAGGTCTC	0.522000													17	39					0	0	0.000132079	0	0
TMEM89	440955	broad.mit.edu	37	3	48659036	48659036	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:48659036G>A	ENST00000330862.3	-	1	252	c.154C>T	c.(154-156)Ctg>Ttg	p.L52L		NM_001008269.1	NP_001008270.1	A2RUT3	TMM89_HUMAN	transmembrane protein 89	52						integral to membrane				breast(1)|lung(1)|stomach(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GGACAGCTCAGGCCACCCCTA	0.642000													9	23					0	0	0.000442599	0	0
NR2F1	7025	broad.mit.edu	37	5	92924011	92924011	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:92924011C>T	ENST00000327111.3	+	2	2539	c.852C>T	c.(850-852)gcC>gcT	p.A284A		NM_005654.4	NP_005645.1	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	284					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|large_intestine(6)|lung(2)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	21		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		GCCTGCATGCCTCGCCCATGT	0.667000													9	38					0	0	0.00010058	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47243560	47243560	+	Missense_Mutation	SNP	G	G	A	rs147132109		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:47243560G>A	ENST00000300404.2	+	9	1278	c.1219G>A	c.(1219-1221)Gag>Aag	p.E407K	B4GALNT2_ENST00000504681.1_Missense_Mutation_p.E321K|B4GALNT2_ENST00000393354.2_Missense_Mutation_p.E347K	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	407					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			TCTCTTCAACGAGGAGACCAA	0.493000													19	56					0	0	0.000175454	0	0
LRGUK	136332	broad.mit.edu	37	7	133943049	133943049	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr7:133943049C>T	ENST00000285928.2	+	19	2308	c.2239C>T	c.(2239-2241)Cgg>Tgg	p.R747W		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	747							ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						TTCATTGTTTCGGTTCTGTCC	0.448000													42	64					0	0	0.000147903	0	0
NUP210	23225	broad.mit.edu	37	3	13368735	13368735	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:13368735C>T	ENST00000254508.5	-	32	4571	c.4489G>A	c.(4489-4491)Gtt>Att	p.V1497I		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1497					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					CTGGTCAGAACAGTGGCCAGA	0.637000													5	10					0	0	3.59834e-05	0	0
DSC1	1823	broad.mit.edu	37	18	28711671	28711671	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr18:28711671G>A	ENST00000257197.3	-	15	2634	c.2373C>T	c.(2371-2373)tcC>tcT	p.S791S	RP11-408H20.2_ENST00000581836.1_RNA|RP11-408H20.3_ENST00000582307.1_RNA|DSC1_ENST00000257198.5_Silent_p.S791S	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	791					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			CTCCTTTGTTGGAATCCAAAG	0.498000													20	35					0	0	9.22233e-05	0	0
RP11-50E11.3	0	broad.mit.edu	37	10	52389895	52389895	+	RNA	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr10:52389895C>T	ENST00000443374.1	+	0	588																											TATGCTGGGTCGTTTTCCTGA	0.403000													6	10					0	0	0.000157383	0	0
PSG8	440533	broad.mit.edu	37	19	43269712	43269712	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:43269712G>A	ENST00000404209.4	-	1	118	c.22C>T	c.(22-24)Ccc>Tcc	p.P8S	PSG8_ENST00000306511.4_Missense_Mutation_p.P8S|PSG8_ENST00000406636.3_Missense_Mutation_p.P8S|PSG8_ENST00000401467.2_Intron	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	8						extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				TGTGTGCAGGGAGGGGCTGAG	0.597000													5	68					0	0	0.000274275	0	0
OR10H4	126541	broad.mit.edu	37	19	16060767	16060767	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:16060767G>A	ENST00000322107.1	+	1	950	c.948_splice	c.e1+1	p.*317_splice		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						CCAAGTTCCTGAGCGCCAGTT	0.388000													17	24					0	0	5.01169e-05	0	0
XDH	7498	broad.mit.edu	37	2	31610747	31610747	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:31610747G>A	ENST00000379416.3	-	8	629	c.581C>T	c.(580-582)tCt>tTt	p.S194F	XDH_ENST00000491727.1_5'UTR	NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	194					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TTTGAATAAAGATGGCGAGAG	0.532000													8	4					0	0	3.86212e-05	0	0
NPY1R	4886	broad.mit.edu	37	4	164246878	164246878	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:164246878C>T	ENST00000296533.2	-	3	1263	c.732G>A	c.(730-732)atG>atA	p.M244I	NPY1R_ENST00000509586.1_Start_Codon_SNP_p.M1I	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	244					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TCTTGTCCATCATGTTGTTTC	0.363000													5	34					0	0	3.59834e-05	0	0
CNKSR1	10256	broad.mit.edu	37	1	26507371	26507371	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:26507371C>T	ENST00000361530.6	+	3	521	c.376C>T	c.(376-378)Ctc>Ttc	p.L126F	CNKSR1_ENST00000480348.2_3'UTR|CNKSR1_ENST00000531191.1_5'UTR|CNKSR1_ENST00000374253.5_Missense_Mutation_p.L126F			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	126	CRIC.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		TGACGCCCTCCTCTTCTGGCT	0.572000													14	24					0	0	5.01169e-05	0	0
ERC2	26059	broad.mit.edu	37	3	56330239	56330239	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:56330239C>T	ENST00000288221.6	-	3	1137	c.882G>A	c.(880-882)caG>caA	p.Q294Q		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	294						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GGGTTTGTTTCTGCGTTTCAA	0.458000													75	314					0	0	0.000147903	0	0
SCN11A	11280	broad.mit.edu	37	3	38888407	38888407	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:38888407C>T	ENST00000302328.3	-	26	5352	c.5154G>A	c.(5152-5154)aaG>aaA	p.K1718K	SCN11A_ENST00000450244.1_Silent_p.K1718K|SCN11A_ENST00000456224.3_Silent_p.K1680K	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1718					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.K1718N(1)		NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CATACAACTTCTTGAGAGGAT	0.448000													7	79					0	0	0.000274275	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256433	69256433	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:69256433G>A	ENST00000439696.2	-	2	1135	c.834C>T	c.(832-834)ctC>ctT	p.L278L	ZFP36L1_ENST00000336440.3_Silent_p.L278L|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	278					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TGGGCCGGAAGAGGAAGGTGG	0.627000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	54					0	0	0.00010058	0	0
DNAH7	56171	broad.mit.edu	37	2	196851789	196851789	+	Splice_Site	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:196851789C>T	ENST00000312428.6	-	14	1855		c.e14+1			NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CACATAAATACCTTGTATTTA	0.343000													47	42					0	0	0.000147903	0	0
NFKB1	4790	broad.mit.edu	37	4	103459077	103459077	+	Silent	SNP	T	T	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:103459077T>G	ENST00000226574.4	+	5	689	c.222T>G	c.(220-222)tcT>tcG	p.S74S	NFKB1_ENST00000505458.1_Silent_p.S73S|NFKB1_ENST00000394820.4_Silent_p.S73S	NM_001165412.1|NM_003998.3	NP_001158884.1|NP_003989.2	P19838	NFKB1_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	73	RHD.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			biliary_tract(1)|breast(4)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	CTGGTGCCTCTAGTGAAAAGA	0.408000													11	17					0	0	6.40141e-05	0	0
IQCJ-SCHIP1	100505385	broad.mit.edu	37	3	159605586	159605586	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:159605586G>A	ENST00000337808.6	+	5	1663	c.1086G>A	c.(1084-1086)aaG>aaA	p.K362K	IQCJ-SCHIP1_ENST00000412423.2_Silent_p.K349K|IQCJ-SCHIP1_ENST00000460298.1_Silent_p.K322K|IQCJ-SCHIP1_ENST00000485419.1_Silent_p.K438K|IQCJ-SCHIP1_ENST00000476809.1_Silent_p.K411K|IQCJ-SCHIP1_ENST00000527095.1_Silent_p.K130K|SCHIP1_ENST00000482804.1_Silent_p.K135K|SCHIP1_ENST00000445224.2_Silent_p.K119K	NM_001197107.1|NM_014575.3	NP_001184036.1|NP_055390.1	Q9P0W5	SCHI1_HUMAN		362						cytoplasm	identical protein binding|protein binding	p.K362N(1)|p.K438N(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(7)	12						CAAGGCAAAAGAAATTGCAAG	0.453000													33	135					0	0	0.000409698	0	0
UGT2B10	7365	broad.mit.edu	37	4	69681842	69681842	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:69681842G>A	ENST00000265403.7	+	1	132	c.105G>A	c.(103-105)tgG>tgA	p.W35*	UGT2B10_ENST00000458688.2_Nonsense_Mutation_p.W35*	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	35					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						ACAGCCTTTGGATGAATATGA	0.438000													9	33					0	0	0.000274275	0	0
PPWD1	23398	broad.mit.edu	37	5	64868010	64868010	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:64868010C>T	ENST00000261308.5	+	5	938	c.866C>T	c.(865-867)tCa>tTa	p.S289L	PPWD1_ENST00000538977.1_Missense_Mutation_p.S133L|PPWD1_ENST00000535264.1_Missense_Mutation_p.S259L	NM_015342.3	NP_056157.1	Q96BP3	PPWD1_HUMAN	peptidylprolyl isomerase domain and WD repeat containing 1	289					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	19		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00451)		GTATGTTTTTCACCAGATGGG	0.333000													29	111					0	0	0.000409698	0	0
CD1E	913	broad.mit.edu	37	1	158324454	158324454	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:158324454C>T	ENST00000368160.3	+	2	346	c.346C>T	c.(346-348)Cag>Tag	p.Q116*	CD1E_ENST00000368166.3_Intron|CD1E_ENST00000368155.3_Nonsense_Mutation_p.Q116*|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000368163.3_Nonsense_Mutation_p.Q116*|CD1E_ENST00000464822.1_Intron|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000444681.2_Intron|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000368167.3_Nonsense_Mutation_p.Q116*|CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368156.1_Nonsense_Mutation_p.Q116*|CD1E_ENST00000368161.3_Nonsense_Mutation_p.Q116*|CD1E_ENST00000434258.1_Nonsense_Mutation_p.Q114*|CD1E_ENST00000368165.3_Nonsense_Mutation_p.Q116*	NM_001042583.2	NP_001036048.1	P15812	CD1E_HUMAN	CD1e molecule	116					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					TGGTCAATTTCAGCTTGAATG	0.388000													11	26					0	0	0.00010058	0	0
TAF1L	138474	broad.mit.edu	37	9	32632781	32632781	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:32632781C>T	ENST00000242310.4	-	1	2886	c.2797G>A	c.(2797-2799)Gaa>Aaa	p.E933K		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	933					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCCTCATTTTCTTCTTCTGGG	0.463000													18	91					0	0	0.000175454	0	0
HYDIN	54768	broad.mit.edu	37	16	71007785	71007785	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr16:71007785G>A	ENST00000393567.2	-	34	5326	c.5176C>T	c.(5176-5178)Cat>Tat	p.H1726Y		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1726										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				ACTTGGAGATGATTGGAAAGC	0.488000													15	81					0	0	5.01169e-05	0	0
SEC16A	9919	broad.mit.edu	37	9	139369253	139369253	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr9:139369253G>A	ENST00000313050.7	-	1	2888	c.2815C>T	c.(2815-2817)Cca>Tca	p.P939S	SEC16A_ENST00000371706.3_Missense_Mutation_p.P761S|SEC16A_ENST00000290037.6_Missense_Mutation_p.P761S|SEC16A_ENST00000431893.2_Missense_Mutation_p.P761S	NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	761	Pro-rich.|Required for endoplasmic reticulum localization.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		TGACTTTCTGGAACCAAGTTC	0.483000													26	70					0	0	0.000109025	0	0
ADAM21	8747	broad.mit.edu	37	14	70924317	70924317	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:70924317C>T	ENST00000603540.1	+	2	359	c.101C>T	c.(100-102)tCc>tTc	p.S34F	ADAM21_ENST00000267499.3_Missense_Mutation_p.S34F|RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	34					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCTGGGCCCTCCCAGCATTTC	0.547000													22	27					0	0	0.000295444	0	0
AHNAK	79026	broad.mit.edu	37	11	62292054	62292054	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr11:62292054G>A	ENST00000378024.4	-	5	10109	c.9835C>T	c.(9835-9837)Cca>Tca	p.P3279S	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3279					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTCAGTTTTGGACCTTTTAAT	0.413000													49	120					0	0	0.000147903	0	0
HPGDS	27306	broad.mit.edu	37	4	95255745	95255745	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr4:95255745C>T	ENST00000295256.5	-	2	126	c.36G>A	c.(34-36)agG>agA	p.R12R	HPGDS_ENST00000514774.1_5'UTR	NM_014485.2	NP_055300.1	O60760	HPGDS_HUMAN	hematopoietic prostaglandin D synthase	12	GST N-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			breast(1)|cervix(1)|lung(3)|ovary(1)|urinary_tract(1)	7					Glutathione(DB00143)	CTGCTCTCCCCCTCATATTAA	0.368000													11	67					0	0	0.00010058	0	0
RP1L1	94137	broad.mit.edu	37	8	10470595	10470595	+	Missense_Mutation	SNP	A	A	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr8:10470595A>T	ENST00000382483.3	-	4	1236	c.1013T>A	c.(1012-1014)cTa>cAa	p.L338Q		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	338					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCGGGACCATAGGAGCGTGTC	0.647000													33	44					0	0	0.000191422	0	0
ZXDC	79364	broad.mit.edu	37	3	126180628	126180628	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr3:126180628G>A	ENST00000389709.3	-	6	1930	c.1877C>T	c.(1876-1878)gCt>gTt	p.A626V	ZXDC_ENST00000336332.5_Missense_Mutation_p.A626V	NM_025112.4	NP_079388.3	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C	626	Required for transcriptional activation.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(1)	17				GBM - Glioblastoma multiforme(114;0.155)		GGAGGTCAAAGCCAGTGGGTC	0.552000													10	83					0	0	0.00010058	0	0
SPTA1	6708	broad.mit.edu	37	1	158646001	158646001	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:158646001G>A	ENST00000368148.3	-	8	1222	c.1042C>T	c.(1042-1044)Ctg>Ttg	p.L348L	SPTA1_ENST00000368147.3_Silent_p.L348L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	348					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CTGGAGACCAGATCTTCTTTC	0.478000													7	27					0	0	0.000157383	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140347776	140347776	+	Silent	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr5:140347776C>T	ENST00000289269.5	+	1	1957	c.1425C>T	c.(1423-1425)tcC>tcT	p.S475S	PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		475	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTCCTATTCCATCTACATAC	0.498000													40	147					0	0	0.000147903	0	0
CTC1	80169	broad.mit.edu	37	17	8132524	8132524	+	Splice_Site	SNP	C	C	T			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr17:8132524C>T	ENST00000315684.8	-	20	3164	c.3156_splice	c.e20-1	p.G1053_splice		NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	1053					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						GTGCACTTTCCCTGGGATGAA	0.552000													45	83					0	0	0.000125731	0	0
LRP1B	53353	broad.mit.edu	37	2	141259425	141259425	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:141259425G>A	ENST00000389484.3	-	55	9652	c.8681C>T	c.(8680-8682)tCa>tTa	p.S2894L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2894	LDL-receptor class A 20.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATAAAAAATGAACTGTTGCA	0.373000										TSP Lung(27;0.18)			5	12					0	0	8.12818e-05	0	0
SGSM1	129049	broad.mit.edu	37	22	25255730	25255730	+	Silent	SNP	G	G	A			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr22:25255730G>A	ENST00000400358.4	+	9	906	c.849G>A	c.(847-849)acG>acA	p.T283T	SGSM1_ENST00000400359.4_Silent_p.T283T	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	283						Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						TGCACCAGACGGCTGACGTCA	0.592000													11	69					0	0	3.86212e-05	0	0
PEX14	5195	broad.mit.edu	37	1	10684419	10684419	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:10684419delC	ENST00000356607.4	+	7	590	c.510delC	c.(508-510)ctfs	p.L170fs	PEX14_ENST00000538836.1_Frame_Shift_Del_p.L106fs	NM_004565.2	NP_004556.1	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	170					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(3)|endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	13	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		AGACGACCCTCGCCTCCGTCC	0.622													13	136	---	---	---	---					
PADI6	353238	broad.mit.edu	37	1	17721722	17721723	+	RNA	DEL	GA	GA	-	rs58784721		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:17721722_17721723delGA	ENST00000434762.2	+	0	1545							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	tttgttttttgagagtcttgct	0.485													4	7	---	---	---	---					
ZMPSTE24	10269	broad.mit.edu	37	1	40756542	40756543	+	Frame_Shift_Ins	INS	-	-	T	rs137854889		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:40756542_40756543insT	ENST00000372759.3	+	9	1241_1242	c.1076_1077insT	c.(1075-1077)tttfs	p.F359fs		NM_005857.4	NP_005848.2	O75844	FACE1_HUMAN	zinc metallopeptidase STE24	359						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	16	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			TCTTTCCTGTGTTTTTTTTTAT	0.332													7	148	---	---	---	---					
WDR78	79819	broad.mit.edu	37	1	67292641	67292641	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:67292641delT	ENST00000371026.3	-	15	2256	c.2201delA	c.(2200-2202)cgfs	p.Q734fs	RP11-342H21.2_ENST00000456389.1_RNA|WDR78_ENST00000431318.1_Frame_Shift_Del_p.Q447fs	NM_024763.4	NP_079039.4	Q5VTH9	WDR78_HUMAN	WD repeat domain 78	734										NS(1)|endometrium(3)|kidney(6)|large_intestine(6)|lung(10)|ovary(3)|skin(3)	32						GACATTCTCCTGTTGCCATAT	0.373													64	206	---	---	---	---					
KCNN3	3782	broad.mit.edu	37	1	154842331	154842333	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr1:154842331_154842333delTGC	ENST00000271915.3	-	1	423_425	c.108_110delGCA	c.(106-111)caa>ca	p.QQ40del		NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	40	Poly-Gln.					integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			ctgctgctgttgctgctgctgct	0.670													3	6	---	---	---	---					
ZFP36L2	678	broad.mit.edu	37	2	43452622	43452623	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:43452622_43452623insC	ENST00000282388.3	-	2	613_614	c.320_321insG	c.(319-321)gggfs	p.G107fs	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	107	Poly-Gly.				cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.G107G(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				CTGTGCCGCCGCCCCCCGACGG	0.693													8	8	---	---	---	---					
FN1	2335	broad.mit.edu	37	2	216246963	216246964	+	Frame_Shift_Ins	INS	-	-	CT			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr2:216246963_216246964insCT	ENST00000354785.4	-	32	5504_5505	c.5135_5136insAG	c.(5134-5136)acafs	p.T1712fs	FN1_ENST00000323926.6_Frame_Shift_Ins_p.T1712fs|FN1_ENST00000359671.1_Frame_Shift_Ins_p.T1621fs|FN1_ENST00000446046.1_Frame_Shift_Ins_p.T1621fs|FN1_ENST00000432072.2_Frame_Shift_Ins_p.T1712fs|FN1_ENST00000356005.4_Frame_Shift_Ins_p.T1621fs|FN1_ENST00000421182.1_Frame_Shift_Ins_p.T1621fs|FN1_ENST00000357867.4_Frame_Shift_Ins_p.T1621fs|FN1_ENST00000357009.2_Frame_Shift_Ins_p.T1621fs|FN1_ENST00000346544.3_Frame_Shift_Ins_p.T1621fs|FN1_ENST00000345488.5_Frame_Shift_Ins_p.T1621fs|FN1_ENST00000443816.1_Frame_Shift_Ins_p.T1621fs|FN1_ENST00000336916.4_Frame_Shift_Ins_p.T1621fs|FN1_ENST00000490833.1_5'UTR			P02751	FINC_HUMAN	fibronectin 1	1711	Fibronectin type-III 12; extra domain.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCAGAGGCTGACTCTCTCCGCT	0.455													16	55	---	---	---	---					
ARID2	196528	broad.mit.edu	37	12	46245553	46245553	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr12:46245553delC	ENST00000334344.6	+	15	3819	c.3647delC	c.(3646-3648)agfs	p.T1216fs	ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Frame_Shift_Del_p.T1067fs|ARID2_ENST00000444670.1_Frame_Shift_Del_p.T826fs	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1216					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CCAGTACAAACGCTTCCAGCC	0.483			"""N, S, F"""		hepatocellular carcinoma								7	15	---	---	---	---					
PYGL	5836	broad.mit.edu	37	14	51376772	51376773	+	Frame_Shift_Ins	INS	-	-	C	rs113993984		TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr14:51376772_51376773insC	ENST00000216392.7	-	17	2349_2350	c.2017_2018insG	c.(2017-2019)agcfs	p.S673fs	PYGL_ENST00000544180.2_Frame_Shift_Ins_p.S639fs|PYGL_ENST00000532462.1_Frame_Shift_Ins_p.S673fs	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	673					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	CCCCGAGGCTTCGGTGCCTGCA	0.475													51	96	---	---	---	---					
POLG	5428	broad.mit.edu	37	15	89870251	89870252	+	In_Frame_Ins	INS	-	-	CAGGTCCCACTC			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr15:89870251_89870252insCAGGTCCCACTC	ENST00000268124.5	-	8	1809_1810	c.1476_1477insGAGTGGGACCTG	c.(1474-1479)ctaaga>ctGAGTGGGACCTGaaga	p.492_493LR>LSGT*R	POLG_ENST00000442287.2_In_Frame_Ins_p.492_493LR>LSGT*R	NM_001126131.1|NM_002693.2	NP_001119603.1|NP_002684.1	P54098	DPOG1_HUMAN	polymerase (DNA directed), gamma	492					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(3)|urinary_tract(2)	33	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			TTAAATTCTTGCAGGTCCCACT	0.584								DNA polymerases (catalytic subunits)					11	217	---	---	---	---					
HOMER3	9454	broad.mit.edu	37	19	19042906	19042906	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr19:19042906delA	ENST00000539827.1	-	6	1221	c.569delT	c.(568-570)tcfs	p.F190fs	HOMER3_ENST00000221222.11_Frame_Shift_Del_p.F190fs|AC002985.3_ENST00000596918.1_Intron|HOMER3_ENST00000542541.2_Frame_Shift_Del_p.F190fs|HOMER3_ENST00000594794.1_Intron|HOMER3_ENST00000433218.2_Frame_Shift_Del_p.F190fs|HOMER3_ENST00000355887.6_Frame_Shift_Del_p.F190fs|HOMER3_ENST00000392351.3_Frame_Shift_Del_p.F190fs|HOMER3_ENST00000594439.1_Frame_Shift_Del_p.F154fs			Q9NSC5	HOME3_HUMAN	homer homolog 3 (Drosophila)	190					metabotropic glutamate receptor signaling pathway|protein targeting	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	protein binding			endometrium(3)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	10			Epithelial(12;0.0107)			CTGCAGTGCGAAAAACTCGGC	0.687													2	4	---	---	---	---					
RRBP1	6238	broad.mit.edu	37	20	17617376	17617377	+	Splice_Site	INS	-	-	G			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chr20:17617376_17617377insG	ENST00000377813.1	-	6	2488		c.e6-2		RRBP1_ENST00000455029.2_Splice_Site|RRBP1_ENST00000360807.4_Splice_Site|RRBP1_ENST00000246043.4_Splice_Site|RRBP1_ENST00000377807.2_Splice_Site			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1						protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						TGCCATCTCCTGGGGGGAAAGT	0.619													28	68	---	---	---	---					
SOWAHD	347454	broad.mit.edu	37	X	118893300	118893301	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BF-A1Q0-01A-21D-A19A-08	TCGA-BF-A1Q0-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8597b25-8541-43e0-b46c-e54e2eaca473	9ae35461-c8d7-4a2e-88b9-8bf14458a975	g.chrX:118893300_118893301insC	ENST00000343905.3	+	1	725_726	c.670_671insC	c.(670-672)ctgfs	p.L224fs		NM_001105576.2	NP_001099046.1	A6NJG2	ANR58_HUMAN	sosondowah ankyrin repeat domain family member D	224																	CGGCCACCGGGCCTGCCACTAC	0.703													2	4	---	---	---	---