Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARMC3	219681	broad.mit.edu	37	10	23326295	23326295	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr10:23326295G>A	ENST00000298032.5	+	19	2590	c.2506G>A	c.(2506-2508)Gga>Aga	p.G836R	ARMC3_ENST00000409983.3_Missense_Mutation_p.G829R|ARMC3_ENST00000376528.4_Missense_Mutation_p.G573R	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	836							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CTCTCGGAAGGGAGTGATTGG	0.527000													14	25					0	0	1.49906e-05	0	0
ITPR3	3710	broad.mit.edu	37	6	33639958	33639958	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr6:33639958G>T	ENST00000374316.5	+	23	3941	c.2881G>T	c.(2881-2883)Gac>Tac	p.D961Y	ITPR3_ENST00000605930.1_Missense_Mutation_p.D961Y			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	961					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						GGAGAATGAGGACATTGTGGT	0.592000													17	91					5.26018e-13	5.08255e-11	2.27731e-05	1	0
DEF6	50619	broad.mit.edu	37	6	35289033	35289033	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr6:35289033C>T	ENST00000316637.5	+	11	1747	c.1742C>T	c.(1741-1743)tCc>tTc	p.S581F	DEF6_ENST00000542066.1_Missense_Mutation_p.S326F	NM_022047.3	NP_071330.3	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog (mouse)	581						cytoplasm|nucleus|plasma membrane				cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	15						CGTGACTCCTCCCTAAAGCGC	0.617000													39	149					0	0	5.1965e-05	0	0
PCDHB16	57717	broad.mit.edu	37	5	140564441	140564441	+	Silent	SNP	G	G	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr5:140564441G>A	ENST00000361016.2	+	1	3462	c.2307G>A	c.(2305-2307)ccG>ccA	p.P769P		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		769					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTGAAGCCGATTATCCCCA	0.458000													17	47					0	0	5.01169e-05	0	0
KCNS2	3788	broad.mit.edu	37	8	99441459	99441459	+	Missense_Mutation	SNP	C	C	T	rs149723156		TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr8:99441459C>T	ENST00000287042.4	+	2	1602	c.1252C>T	c.(1252-1254)Cgg>Tgg	p.R418W	KCNS2_ENST00000521839.1_Missense_Mutation_p.R418W	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	418						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CCACTTTTACCGGCGCCAAAA	0.517000													28	214					0	0	0.000147802	0	0
TTPAL	79183	broad.mit.edu	37	20	43115234	43115234	+	Splice_Site	SNP	A	A	G			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr20:43115234A>G	ENST00000372904.3	+	5	782		c.e5-1		TTPAL_ENST00000262605.4_Splice_Site|TTPAL_ENST00000372906.2_Intron	NM_024331.4	NP_077307.2	Q9BTX7	TTPAL_HUMAN	tocopherol (alpha) transfer protein-like							intracellular	transporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(2)|skin(5)	18						TTTCCCACACAGGATGGTTTC	0.423000													25	49					0	0	0.000147802	0	0
TECTA	7007	broad.mit.edu	37	11	121031078	121031078	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr11:121031078G>A	ENST00000392793.1	+	15	5195	c.4924G>A	c.(4924-4926)Gta>Ata	p.V1642I	TECTA_ENST00000264037.2_Missense_Mutation_p.V1642I			O75443	TECTA_HUMAN	tectorin alpha	1642	VWFD 4.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GAAGCCGGTGGTAAGCAGCGT	0.552000													45	72					0	0	0.000147903	0	0
TTN	7273	broad.mit.edu	37	2	179480121	179480121	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr2:179480121C>G	ENST00000589042.1	-	259	48775	c.48551G>C	c.(48550-48552)gGt>gCt	p.G16184A	TTN_ENST00000460472.2_Missense_Mutation_p.G7119A|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G7244A|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G7311A|TTN_ENST00000591111.1_Missense_Mutation_p.G14543A|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G13616A|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14543	Fibronectin type-III 17.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATGCGTGAACCACCATCATT	0.413000													118	113					0	0	0.000147903	0	0
NRAS	4893	broad.mit.edu	37	1	115258748	115258748	+	Missense_Mutation	SNP	C	C	G	rs121913250		TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr1:115258748C>G	ENST00000369535.4	-	2	287	c.34G>C	c.(34-36)Ggt>Cgt	p.G12R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	12			G -> C (in leukemia).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.G12S(133)|p.G12C(81)|p.G12R(18)|p.G12N(2)|p.G12P(1)|p.G12Y(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCAACACCACCTGCTCCAACC	0.493000	G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			98	32					0	0	0.000147903	0	0
MT2A	4502	broad.mit.edu	37	16	56643177	56643177	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr16:56643177T>C	ENST00000245185.5	+	3	554	c.97T>C	c.(97-99)Tgc>Cgc	p.C33R	MT2A_ENST00000561491.1_3'UTR|MT2A_ENST00000563985.1_3'UTR	NM_005953.3	NP_005944.1	P02795	MT2_HUMAN	metallothionein 2A	33	Alpha.				cellular copper ion homeostasis|interferon-gamma-mediated signaling pathway		metal ion binding|protein binding			breast(1)|endometrium(1)|lung(1)	3						GCCCCCAGGCTGCTGCTCCTG	0.602000													10	34					0	0	3.86212e-05	0	0
GDF3	9573	broad.mit.edu	37	12	7848184	7848184	+	Silent	SNP	C	C	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr12:7848184C>T	ENST00000329913.3	-	1	188	c.141G>A	c.(139-141)gtG>gtA	p.V47V		NM_020634.1	NP_065685.1	Q9NR23	GDF3_HUMAN	growth differentiation factor 3	47					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						AGATATAAGGCACAGGTTGGA	0.507000													15	64					0	0	2.31682e-05	0	0
SAMD9L	219285	broad.mit.edu	37	7	92762797	92762797	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr7:92762797C>T	ENST00000318238.4	-	5	3704	c.2488G>A	c.(2488-2490)Gaa>Aaa	p.E830K	SAMD9L_ENST00000437805.1_Missense_Mutation_p.E830K|SAMD9L_ENST00000411955.1_Missense_Mutation_p.E830K	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	830										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AATGTTTTTTCATATCGCAAA	0.363000													24	123					0	0	3.10358e-05	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													5	54					0	0	1.23904e-05	0	0
FANCD2	2177	broad.mit.edu	37	3	10081425	10081425	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr3:10081425G>C	ENST00000287647.3	+	9	684	c.591G>C	c.(589-591)atG>atC	p.M197I	FANCD2_ENST00000383807.1_Missense_Mutation_p.M197I|FANCD2_ENST00000431693.1_Missense_Mutation_p.M197I|FANCD2_ENST00000419585.1_Missense_Mutation_p.M197I|FANCD2_ENST00000383806.1_Missense_Mutation_p.M197I|FANCD2_ENST00000438741.1_3'UTR	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	197	Interaction with FANCE.				DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		CCAAGATCATGCAGCTGATCA	0.488000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				16	47					0	0	5.01169e-05	0	0
CFLAR	8837	broad.mit.edu	37	2	201997825	201997825	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr2:201997825T>G	ENST00000395148.2	+	3	567	c.355T>G	c.(355-357)Tac>Gac	p.Y119D	CFLAR_ENST00000479953.2_Missense_Mutation_p.Y23D|CFLAR_ENST00000443227.1_Missense_Mutation_p.Y23D|CFLAR_ENST00000355558.4_Missense_Mutation_p.Y119D|CFLAR_ENST00000309955.2_Missense_Mutation_p.Y119D|CFLAR_ENST00000341222.6_Missense_Mutation_p.Y119D|CFLAR_ENST00000340870.5_Missense_Mutation_p.Y119D|CFLAR_ENST00000457277.1_Missense_Mutation_p.Y119D|CFLAR_ENST00000423241.2_Missense_Mutation_p.Y119D|CFLAR_ENST00000341582.6_Missense_Mutation_p.Y119D|CFLAR_ENST00000440180.1_Missense_Mutation_p.Y119D|CFLAR_ENST00000342795.5_Missense_Mutation_p.Y119D|CFLAR_ENST00000494258.1_Missense_Mutation_p.Y23D			O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator	119	DED 2.|Interaction with FADD.|Interaction with caspase-8 propeptide.|Interaction with caspase-8.|Not proteolytically processed and involved in apoptosis inhibition.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|stomach(1)	13						CATGAAGGATTACATGGGCCG	0.438000													5	30					0	0	3.59834e-05	0	0
EPC2	26122	broad.mit.edu	37	2	149528378	149528378	+	Silent	SNP	T	T	G			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr2:149528378T>G	ENST00000258484.6	+	9	1282	c.1248T>G	c.(1246-1248)gcT>gcG	p.A416A		NM_015630.3	NP_056445.3	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2 (Drosophila)	416					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0516)		TGGACCAAGCTAACCATTCAT	0.353000													19	66					0	0	1.64113e-05	0	0
ADHFE1	137872	broad.mit.edu	37	8	67372548	67372548	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr8:67372548G>A	ENST00000396623.3	+	13	1199	c.1168G>A	c.(1168-1170)Gac>Aac	p.D390N	ADHFE1_ENST00000415254.1_Missense_Mutation_p.D342N|ADHFE1_ENST00000496501.1_3'UTR|C8orf46_ENST00000482608.2_3'UTR	NM_144650.2	NP_653251.2	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	390					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	29		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			TCTAGGAGCCGACACCCGCAC	0.527000											OREG0018808	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	203					0	0	4.16121e-05	0	0
FRG1B	284802	broad.mit.edu	37	20	29628299	29628299	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr20:29628299A>G	ENST00000278882.3	+	6	681	c.301A>G	c.(301-303)Agt>Ggt	p.S101G	FRG1B_ENST00000358464.4_Missense_Mutation_p.S101G|FRG1B_ENST00000439954.2_Missense_Mutation_p.S106G																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AGAAGCAAAAAGTAAAACAGC	0.363000													4	63					0	0	1.23904e-05	0	0
COPA	1314	broad.mit.edu	37	1	160281719	160281719	+	Silent	SNP	G	G	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr1:160281719G>T	ENST00000241704.7	-	11	1244	c.1015C>A	c.(1015-1017)Cga>Aga	p.R339R	COPA_ENST00000368069.3_Silent_p.R339R	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	339					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CGTAAGAATCGGTCCTTGACA	0.488000													5	65					8.12818e-05	0.00732305	8.12818e-05	1	0
UBE2M	9040	broad.mit.edu	37	19	59067503	59067503	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr19:59067503G>A	ENST00000253023.3	-	6	1083	c.505C>T	c.(505-507)Cgg>Tgg	p.R169W		NM_003969.3	NP_003960.1	P61081	UBC12_HUMAN	ubiquitin-conjugating enzyme E2M	169					protein neddylation		ATP binding|NEDD8 ligase activity|protein binding|ribosomal S6-glutamic acid ligase activity|ubiquitin-protein ligase activity			large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	5		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TAGCCACCCCGCATGGAGCGC	0.642000													13	49					0	0	2.31682e-05	0	0
SLC6A5	9152	broad.mit.edu	37	11	20629080	20629080	+	Silent	SNP	G	G	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr11:20629080G>T	ENST00000525748.1	+	5	1140	c.867G>T	c.(865-867)gtG>gtT	p.V289V		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	289					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	ACTACAATGTGATTATTTGCT	0.438000													55	63					3.36121e-32	3.39533e-30	0.000147903	1	0
COL11A2	1302	broad.mit.edu	37	6	33146878	33146878	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr6:33146878G>A	ENST00000341947.2	-	16	1810	c.1583C>T	c.(1582-1584)aCa>aTa	p.T528I	COL11A2_ENST00000357486.1_Missense_Mutation_p.T507I|COL11A2_ENST00000374714.1_Missense_Mutation_p.T502I|COL11A2_ENST00000374713.1_Missense_Mutation_p.T481I|COL11A2_ENST00000374712.1_Missense_Mutation_p.T447I|COL11A2_ENST00000361917.1_Missense_Mutation_p.T421I|COL11A2_ENST00000374708.4_Missense_Mutation_p.T442I|COL11A2_ENST00000395197.1_Missense_Mutation_p.T468I	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	528	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						AGGAGGGCCTGTGAGGCCCTG	0.657000													7	35					0	0	5.18039e-06	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													5	44					0	0	1.23904e-05	0	0
TRIM9	114088	broad.mit.edu	37	14	51446212	51446212	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr14:51446212T>C	ENST00000298355.3	-	9	3084	c.1963A>G	c.(1963-1965)Aga>Gga	p.R655G	TRIM9_ENST00000338969.5_Missense_Mutation_p.R736G	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	655	B30.2/SPRY.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					AAGTTTTTTCTATTTAAGTCG	0.448000													42	107					0	0	0.000147903	0	0
TRIM28	10155	broad.mit.edu	37	19	59060419	59060419	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr19:59060419C>T	ENST00000253024.5	+	12	1763	c.1474C>T	c.(1474-1476)Cgc>Tgc	p.R492C	TRIM28_ENST00000341753.6_Missense_Mutation_p.R410C	NM_005762.2	NP_005753.1	Q13263	TIF1B_HUMAN	tripartite motif containing 28	492	HP1 box.				epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			biliary_tract(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		GAGCCTTGAACGCCTGGACCT	0.582000													21	26					0	0	3.10358e-05	0	0
NME8	51314	broad.mit.edu	37	7	37924779	37924779	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr7:37924779A>G	ENST00000199447.4	+	14	1544	c.1172A>G	c.(1171-1173)gAc>gGc	p.D391G	EPDR1_ENST00000476620.1_Intron|NME8_ENST00000440017.1_Missense_Mutation_p.D391G	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	391	NDK 2.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										TTATTGAGAGACAATGGCTTG	0.378000													8	35					0	0	2.17888e-05	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102995935	102995935	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr11:102995935T>C	ENST00000375735.2	+	12	1912	c.1768T>C	c.(1768-1770)Tct>Cct	p.S590P	DYNC2H1_ENST00000398093.3_Missense_Mutation_p.S590P|DYNC2H1_ENST00000334267.7_Missense_Mutation_p.S590P	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	590	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TCGTCAGCTCTCTGCACTTGG	0.363000													12	22					0	0	1.49906e-05	0	0
AP4B1	10717	broad.mit.edu	37	1	114438597	114438597	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr1:114438597C>A	ENST00000369569.1	-	9	1854	c.1574G>T	c.(1573-1575)gGc>gTc	p.G525V	AP4B1_ENST00000462591.1_5'UTR|AP4B1-AS1_ENST00000419536.1_RNA|AP4B1_ENST00000369567.1_Missense_Mutation_p.G357V|AP4B1_ENST00000256658.4_Missense_Mutation_p.G525V	NM_001253852.1	NP_001240781.1	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1 subunit	525					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|prostate(3)	25	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCATCAATGCCAACTAAGAG	0.448000													33	17					4.4194e-11	4.20917e-09	7.24521e-05	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140724807	140724807	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr5:140724807C>T	ENST00000253812.6	+	1	1207	c.1207C>T	c.(1207-1209)Cgc>Tgc	p.R403C	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAATATTACCGCTTAGTGAC	0.468000													20	44					0	0	1.64113e-05	0	0
CDCA3	83461	broad.mit.edu	37	12	6958754	6958754	+	Silent	SNP	C	C	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr12:6958754C>T	ENST00000422785.3	-	4	623	c.519G>A	c.(517-519)agG>agA	p.R173R	CDCA3_ENST00000229265.6_Silent_p.R148R|CDCA3_ENST00000538862.2_Silent_p.R173R|CDCA3_ENST00000540683.1_Silent_p.R173R|CDCA3_ENST00000535406.1_Silent_p.R173R			Q99618	CDCA3_HUMAN	cell division cycle associated 3	173					cell division|mitosis	cytosol				breast(1)|endometrium(1)|large_intestine(4)|lung(1)|stomach(1)	8						TCTCAGGGTCCCTTGAGGGCT	0.517000													47	298					0	0	0.000147903	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													9	62					0	0	1.12685e-05	0	0
WFDC8	90199	broad.mit.edu	37	20	44184401	44184401	+	Silent	SNP	G	G	A	rs150100809	byFrequency	TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr20:44184401G>A	ENST00000357199.4	-	4	462	c.384C>T	c.(382-384)tgC>tgT	p.C128C	WFDC8_ENST00000289953.2_Silent_p.C128C	NM_181510.2	NP_852611.2	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8	128	BPTI/Kunitz inhibitor.					extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|stomach(1)|upper_aerodigestive_tract(1)	15		Myeloproliferative disorder(115;0.0122)				CATTCCCTTCGCAGCCCCTGT	0.468000													27	100					0	0	3.70037e-05	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414855	14414855	+	RNA	SNP	A	A	G	rs141732548	by1000genomes	TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr21:14414855A>G	ENST00000507941.1	+	0	95																											GCCAATGGCCATGCAGAAGTA	0.448000													5	43					0	0	8.12818e-05	0	0
ZNF669	79862	broad.mit.edu	37	1	247264377	247264377	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr1:247264377C>T	ENST00000343381.6	-	4	866	c.694G>A	c.(694-696)Gtt>Att	p.V232I	ZNF669_ENST00000366501.1_3'UTR|ZNF669_ENST00000448299.2_Missense_Mutation_p.V146I|ZNF669_ENST00000358785.4_3'UTR|ZNF669_ENST00000366500.1_3'UTR	NM_024804.2	NP_079080.2	Q96BR6	ZN669_HUMAN	zinc finger protein 669	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(4)|large_intestine(2)|lung(6)	17	all_cancers(71;4.09e-05)|all_epithelial(71;6.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0283)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00427)			GGAACAGAAACGAAGAATTTC	0.378000													130	11					0	0	0.000147903	0	0
CDK5	1020	broad.mit.edu	37	7	150752177	150752177	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr7:150752177G>C	ENST00000485972.1	-	9	1268	c.587C>G	c.(586-588)gCc>gGc	p.A196G	CDK5_ENST00000297518.4_Missense_Mutation_p.A164G	NM_004935.3	NP_004926.1	Q00535	CDK5_HUMAN	cyclin-dependent kinase 5	196	Protein kinase.				activation of pro-apoptotic gene products|blood coagulation|cell division|cell proliferation|embryo development|negative regulation of transcription, DNA-dependent|positive regulation of neuron apoptosis	axon|cytosol|dendrite|growth cone|lamellipodium|membrane|neuromuscular junction|neuronal cell body	acetylcholine receptor activator activity|ATP binding|cyclin-dependent protein kinase activity|ErbB-2 class receptor binding|ErbB-3 class receptor binding|tau-protein kinase activity			central_nervous_system(1)|endometrium(2)|lung(5)|urinary_tract(1)	9		Breast(660;0.159)|Ovarian(593;0.182)	OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.008)|Lung(243;0.00942)|BRCA - Breast invasive adenocarcinoma(188;0.242)		CCCAGCATTGGCCAGCTCTGG	0.582000													14	52					0	0	3.45872e-05	0	0
ZFP41	286128	broad.mit.edu	37	8	144332324	144332324	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr8:144332324G>A	ENST00000330701.4	+	2	680	c.311G>A	c.(310-312)cGc>cAc	p.R104H	ZFP41_ENST00000520584.1_Missense_Mutation_p.R104H|ZFP41_ENST00000522452.1_Missense_Mutation_p.R104H	NM_173832.3	NP_776193.1	Q8N8Y5	ZFP41_HUMAN	ZFP41 zinc finger protein	104					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|lung(4)|ovary(1)	8	all_cancers(97;1.01e-10)|all_epithelial(106;4.6e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GACCACATTCGCCATCAGAGG	0.547000													16	150					0	0	5.01169e-05	0	0
MAFB	9935	broad.mit.edu	37	20	39317284	39317284	+	Silent	SNP	C	C	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr20:39317284C>T	ENST00000373313.2	-	1	596	c.207G>A	c.(205-207)tcG>tcA	p.S69S	MAFB_ENST00000396967.1_Silent_p.S69S	NM_005461.3	NP_005452.2	Q9Y5Q3	MAFB_HUMAN	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B	69					negative regulation of erythrocyte differentiation		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			kidney(1)|large_intestine(1)	2		Myeloproliferative disorder(115;0.00878)				AGCTGGGCGACGAGGGCACGG	0.667000			T	IGH@	MM								32	76					0	0	0.000109025	0	0
MARCH7	64844	broad.mit.edu	37	2	160604709	160604709	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr2:160604709C>A	ENST00000259050.3	+	5	1030	c.908C>A	c.(907-909)tCc>tAc	p.S303Y	MARCH7_ENST00000539065.1_Missense_Mutation_p.S247Y|MARCH7_ENST00000409175.1_Missense_Mutation_p.S303Y|MARCH7_ENST00000409591.1_Missense_Mutation_p.S265Y	NM_022826.2	NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase	303	Ser-rich.						ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						AGTCAGGATTCCTTGAATACA	0.403000													18	53					2.39187e-15	2.34509e-13	0.000132079	1	0
ST18	9705	broad.mit.edu	37	8	53077718	53077718	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr8:53077718G>T	ENST00000276480.7	-	12	1955	c.1272C>A	c.(1270-1272)aaC>aaA	p.N424K		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	424						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TGCGGTTGCTGTTCACATGAC	0.403000													60	427					2.67592e-24	2.66274e-22	0.000147903	1	0
HIGD1C	613227	broad.mit.edu	37	12	51347824	51347824	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr12:51347824C>T	ENST00000398455.3	+	1	120	c.43C>T	c.(43-45)Caa>Taa	p.Q15*		NM_001109619.1	NP_001103089.1	A8MV81	HIG1C_HUMAN	HIG1 hypoxia inducible domain family, member 1C	15	HIG1.					integral to membrane				lung(1)	1						GGATGAAGGCCAATTATCCCG	0.378000													54	205					0	0	0.000147903	0	0
SULF2	55959	broad.mit.edu	37	20	46318883	46318883	+	Missense_Mutation	SNP	C	C	T	rs142401598		TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr20:46318883C>T	ENST00000359930.4	-	5	1575	c.724G>A	c.(724-726)Gca>Aca	p.A242T	SULF2_ENST00000467815.1_Missense_Mutation_p.A242T|SULF2_ENST00000361612.4_Missense_Mutation_p.A242T|SULF2_ENST00000484875.1_Missense_Mutation_p.A242T	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	242					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						TGCTGAGATGCGTTTGGGAAG	0.572000													10	56					0	0	2.17888e-05	0	0
MITD1	129531	broad.mit.edu	37	2	99785865	99785865	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr2:99785865A>T	ENST00000289359.2	-	7	799	c.723T>A	c.(721-723)ttT>ttA	p.F241L	MRPL30_ENST00000410042.1_Intron	NM_138798.1	NP_620153.1	Q8WV92	MITD1_HUMAN	MIT, microtubule interacting and transport, domain containing 1	241					protein transport	late endosome membrane				large_intestine(3)|lung(2)|ovary(1)	6						GCTTCTTATGAAAAATGTCTA	0.274000													11	45					0	0	6.40141e-05	0	0
FRG1B	284802	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	C	rs145412486	by1000genomes	TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr20:29628236G>C	ENST00000278882.3	+	6	618	c.238G>C	c.(238-240)Gct>Cct	p.A80P	FRG1B_ENST00000358464.4_Missense_Mutation_p.A80P|FRG1B_ENST00000439954.2_Missense_Mutation_p.A85P														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													10	99					0	0	9.31168e-06	0	0
RNF2	6045	broad.mit.edu	37	1	185062302	185062302	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr1:185062302T>C	ENST00000367510.3	+	4	646	c.358T>C	c.(358-360)Tat>Cat	p.Y120H	RNF2_ENST00000367509.4_Intron	NM_007212.3	NP_009143.1	Q99496	RING2_HUMAN	ring finger protein 2	120	Interaction with HIP2.				histone H2A monoubiquitination|transcription, DNA-dependent	MLL1 complex|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			breast(3)|endometrium(2)|large_intestine(4)|lung(3)|skin(2)	14		Breast(1374;0.000496)		Colorectal(1306;6.9e-08)|KIRC - Kidney renal clear cell carcinoma(1967;8.12e-06)		TCGTGATGAGTATGAAGCTCA	0.423000													27	32					0	0	2.25844e-05	0	0
MYH8	4626	broad.mit.edu	37	17	10318882	10318882	+	Silent	SNP	G	G	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr17:10318882G>A	ENST00000403437.2	-	7	649	c.555C>T	c.(553-555)gcC>gcT	p.A185A	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	185	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CAGTCTTTCCGGCACCAGATT	0.438000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				5	96					0	0	5.18039e-06	0	0
SMC1A	8243	broad.mit.edu	37	X	53438820	53438820	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chrX:53438820G>C	ENST00000322213.4	-	7	1272	c.1145C>G	c.(1144-1146)gCc>gGc	p.A382G	SMC1A_ENST00000375340.6_Missense_Mutation_p.A148G	NM_006306.2	NP_006297.2	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	382					cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(8)|ovary(5)|upper_aerodigestive_tract(2)	49						TCTCTTGCTGGCTTCTTCTTT	0.527000													15	3					0	0	1.49906e-05	0	0
LYG2	254773	broad.mit.edu	37	2	99861803	99861803	+	Silent	SNP	G	G	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr2:99861803G>T	ENST00000409679.1	-	4	447	c.303C>A	c.(301-303)atC>atA	p.I101I	LYG2_ENST00000409238.1_Silent_p.I101I|LYG2_ENST00000333017.2_Silent_p.I101I			Q86SG7	LYG2_HUMAN	lysozyme G-like 2	101					cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity			large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(1)|stomach(1)	12						CCCTGGAGATGATGGCTGCGA	0.498000													15	66					6.31663e-08	5.7689e-06	2.31682e-05	1	0
SLC6A7	6534	broad.mit.edu	37	5	149581914	149581914	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr5:149581914G>C	ENST00000230671.2	+	7	1234	c.863G>C	c.(862-864)tGg>tCg	p.W288S	SLC6A7_ENST00000524041.1_Missense_Mutation_p.W288S	NM_014228.3	NP_055043.2	Q99884	SC6A7_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 7	288						integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(1)|stomach(1)	16		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	GCACAGGTGTGGATTGAAGCT	0.547000													33	77					0	0	0.000132358	0	0
FRG1B	284802	broad.mit.edu	37	20	29628278	29628278	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr20:29628278G>A	ENST00000278882.3	+	6	660	c.280G>A	c.(280-282)Gca>Aca	p.A94T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A94T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A99T																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGCAATGAAGCAGGGGACAT	0.373000													5	87					0	0	5.18039e-06	0	0
ZNF2	7549	broad.mit.edu	37	2	95846850	95846850	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr2:95846850T>A	ENST00000398107.2	+	4	673	c.151T>A	c.(151-153)Tgg>Agg	p.W51R	ZNF2_ENST00000295210.6_Missense_Mutation_p.W55R|ZNF2_ENST00000340539.5_Missense_Mutation_p.W93R|ZNF2_ENST00000453539.2_Missense_Mutation_p.W106R|ZNF2_ENST00000425369.1_Missense_Mutation_p.W13R	NM_001017396.1	NP_001017396.1	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2	93	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	12		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		TGTTCCAGACTGGGAAACTAA	0.408000													22	72					0	0	2.27731e-05	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767823	77767823	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr8:77767823C>G	ENST00000521891.2	+	10	9114	c.8666C>G	c.(8665-8667)aCa>aGa	p.T2889R	ZFHX4_ENST00000050961.6_Missense_Mutation_p.T2844R|ZFHX4_ENST00000518282.1_Missense_Mutation_p.T2863R|ZFHX4_ENST00000455469.2_Missense_Mutation_p.T2844R	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2844						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTTTACATCACAGATGACCCG	0.502000										HNSCC(33;0.089)			11	95					0	0	3.86212e-05	0	0
ZNF777	27153	broad.mit.edu	37	7	149128939	149128939	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr7:149128939G>T	ENST00000247930.4	-	6	2747	c.2424C>A	c.(2422-2424)tgC>tgA	p.C808*		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CGCAGTGCGTGCAGGGGTAGG	0.721000													8	27					2.74318e-10	2.57588e-08	2.17888e-05	1	0
FAM208B	54906	broad.mit.edu	37	10	5788339	5788339	+	Silent	SNP	C	C	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr10:5788339C>T	ENST00000328090.5	+	15	3580	c.2955C>T	c.(2953-2955)ggC>ggT	p.G985G		NM_017782.4	NP_060252.4	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	985																	ATGGGCCTGGCAGTCAGCCAG	0.468000													27	34					0	0	0.000147802	0	0
SLC45A3	85414	broad.mit.edu	37	1	205632106	205632106	+	Silent	SNP	C	C	G			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr1:205632106C>G	ENST00000367145.3	-	3	1108	c.813G>C	c.(811-813)ctG>ctC	p.L271L		NM_033102.2	NP_149093.1	Q96JT2	S45A3_HUMAN	solute carrier family 45, member 3	271					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)|SLC45A3/ELK4(18)|SLC45A3/ETV1(3)|SLC45A3/ETV5_ENST00000306376(2)|SLC45A3/ERG(50)	cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|ovary(3)|prostate(5)	21	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			AGAGCCGGCGCAGGGTGCGGG	0.677000			T	"""ETV1, ETV5, ELK4, ERG"""	prostate								22	39					0	0	3.10358e-05	0	0
SNED1	25992	broad.mit.edu	37	2	242011004	242011004	+	Silent	SNP	C	C	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr2:242011004C>T	ENST00000310397.8	+	25	3603	c.3603C>T	c.(3601-3603)ggC>ggT	p.G1201G	SNED1_ENST00000342631.6_Silent_p.G1201G|SNED1_ENST00000405547.3_Silent_p.G1201G|SNED1_ENST00000401884.1_Silent_p.G1201G	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	1201				HSEPAHLYIITSPRDGADRRW -> Q (in Ref. 3; AAQ04558).	cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		CCAGGGATGGCGCTGACAGAC	0.697000													5	5					0	0	8.12818e-05	0	0
MEI1	150365	broad.mit.edu	37	22	42172254	42172254	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr22:42172254G>A	ENST00000401548.3	+	21	2733	c.2693G>A	c.(2692-2694)gGg>gAg	p.G898E	MEI1_ENST00000300398.4_5'UTR|MEI1_ENST00000540880.1_Missense_Mutation_p.G216E|MEI1_ENST00000400107.1_Missense_Mutation_p.G266E	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	898							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						GTGGAGCATGGGGCATCCCCA	0.567000													16	47					0	0	5.01169e-05	0	0
CHPF	79586	broad.mit.edu	37	2	220404347	220404347	+	Missense_Mutation	SNP	C	C	G	rs142415191	byFrequency	TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr2:220404347C>G	ENST00000243776.6	-	4	2334	c.2086G>C	c.(2086-2088)Gaa>Caa	p.E696Q	CHPF_ENST00000535926.1_Missense_Mutation_p.E534Q	NM_024536.5	NP_078812.2	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	696						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)	21		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		TCTTCTTGTTCTGAGGCTGCC	0.647000													29	72					0	0	8.91981e-05	0	0
ACSM1	116285	broad.mit.edu	37	16	20702419	20702419	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr16:20702419G>A	ENST00000307493.4	-	1	159	c.92C>T	c.(91-93)tCt>tTt	p.S31F	ACSM1_ENST00000520010.1_Missense_Mutation_p.S31F|ACSM1_ENST00000219151.4_5'UTR	NM_052956.2	NP_443188.2	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	31					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						TTCTGATAAAGACCGGCAGCG	0.498000													46	137					0	0	0.000147903	0	0
GPRIN1	114787	broad.mit.edu	37	5	176024747	176024747	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr5:176024747C>G	ENST00000303991.4	-	2	2266	c.2089G>C	c.(2089-2091)Gca>Cca	p.A697P		NM_052899.2	NP_443131.2	Q7Z2K8	GRIN1_HUMAN	G protein regulated inducer of neurite outgrowth 1	697						growth cone|plasma membrane				NS(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGGAAGGTGCAGAGTCGGCT	0.597000													12	36					0	0	0.00010058	0	0
TGM1	7051	broad.mit.edu	37	14	24729191	24729191	+	Nonsense_Mutation	SNP	G	G	T	rs147879156		TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr14:24729191G>T	ENST00000206765.6	-	5	954	c.831C>A	c.(829-831)taC>taA	p.Y277*	TGM1_ENST00000544573.1_Intron	NM_000359.2	NP_000350.1	P22735	TGM1_HUMAN	transglutaminase 1	277					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)	24				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	CTTCGGTCCCGTAGTAAATTC	0.557000													17	19					4.35082e-09	4.02874e-07	1.64113e-05	1	0
NOX5	79400	broad.mit.edu	37	15	69325408	69325408	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr15:69325408G>A	ENST00000260364.5	+	6	893	c.592G>A	c.(592-594)Gcc>Acc	p.A198T	NOX5_ENST00000530406.2_Missense_Mutation_p.A188T|NOX5_ENST00000388866.3_Missense_Mutation_p.A216T|NOX5_ENST00000455873.3_Missense_Mutation_p.A181T|NOX5_ENST00000448182.3_Missense_Mutation_p.A170T			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	216	EF-hand 4.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						GAcggcccccgccccccgccc	0.721000													23	9					0	0	2.90539e-05	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74575212	74575213	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr1:74575212_74575213insT	ENST00000354431.4	-	5	923_924	c.732_733insA	c.(730-735)aaagcafs	p.A245fs	LRRIQ3_ENST00000395089.1_Frame_Shift_Ins_p.A245fs|LRRIQ3_ENST00000370909.2_Frame_Shift_Ins_p.A137fs|LRRIQ3_ENST00000468759.1_5'UTR	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	245				QQEKII -> TAGKNY (in Ref. 1; BAD18621).						NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TTTTCCTGCTGTTTTTTTTTGT	0.327													9	92	---	---	---	---					
RP11-782C8.2	0	broad.mit.edu	37	1	143210193	143210194	+	RNA	INS	-	-	T			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr1:143210193_143210194insT	ENST00000412204.2	-	0	876_877				RP11-782C8.1_ENST00000438000.1_lincRNA																							GGCAGCATTTGTTTTTTTAACA	0.317													9	48	---	---	---	---					
ANKRD20A8P	729171	broad.mit.edu	37	2	95513688	95513689	+	RNA	INS	-	-	TA			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr2:95513688_95513689insTA	ENST00000432432.2	-	0	850					NR_040113.1																						CTCACCTAATGTATAAGATGGA	0.327													8	137	---	---	---	---					
POU4F2	5458	broad.mit.edu	37	4	147560457	147560458	+	In_Frame_Ins	INS	-	-	GGC	rs67907220		TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr4:147560457_147560458insGGC	ENST00000281321.3	+	1	413_414	c.165_166insGGC	c.(163-168)gggcgg>ggGGCgcgg	p.55_56GR>GAR	AC093887.1_ENST00000584185.1_RNA	NM_004575.2	NP_004566.2	Q12837	PO4F2_HUMAN	POU class 4 homeobox 2	55	Poly-Gly.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)					ACGCTggtggtggcggcggcgg	0.762													2	4	---	---	---	---					
PEX1	5189	broad.mit.edu	37	7	92146721	92146721	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr7:92146721delT	ENST00000248633.4	-	5	1203	c.1108delA	c.(1108-1110)ttfs	p.I370fs	PEX1_ENST00000428214.1_Frame_Shift_Del_p.I370fs|PEX1_ENST00000541751.1_5'UTR|PEX1_ENST00000438045.1_Intron	NM_000466.2	NP_000457.1	O43933	PEX1_HUMAN	peroxisomal biogenesis factor 1	370					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TCTGACCTAATTTTTTTTTGA	0.353													7	215	---	---	---	---					
CYP26C1	340665	broad.mit.edu	37	10	94828268	94828268	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr10:94828268delC	ENST00000285949.5	+	6	1383	c.1383delC	c.(1381-1383)ggfs	p.G461fs		NM_183374.2	NP_899230.2	Q6V0L0	CP26C_HUMAN	cytochrome P450, family 26, subfamily C, polypeptide 1	461					anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)|lung(3)|ovary(1)	5		Colorectal(252;0.122)				GCTGCCTCGGCCAGGAGCTGG	0.706													2	4	---	---	---	---					
HNRNPKP3	399881	broad.mit.edu	37	11	43283606	43283606	+	RNA	DEL	A	A	-			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr11:43283606delA	ENST00000511537.1	-	0	1329					NR_033868.1																						AAGCAAATGTAAAAAAAAAAA	0.388													2	4	---	---	---	---					
SCAF11	9169	broad.mit.edu	37	12	46318575	46318577	+	In_Frame_Del	DEL	GGT	GGT	-			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr12:46318575_46318577delGGT	ENST00000465950.1	-	2	4104_4106	c.2895_2897delACC	c.(2893-2898)ccc>cc	p.PP969del	SCAF11_ENST00000419565.2_In_Frame_Del_p.PP1284del|SCAF11_ENST00000549162.1_In_Frame_Del_p.PP1092del|SCAF11_ENST00000369367.3_In_Frame_Del_p.PP1284del			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	1284	Arg-rich.				spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						TGGGGGAGGGGGTGGTGGTGGTG	0.483													11	403	---	---	---	---					
RP11-44F14.1	0	broad.mit.edu	37	16	53404542	53404543	+	RNA	INS	-	-	A			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr16:53404542_53404543insA	ENST00000565421.1	-	0	410																											TCTCCTTTCTCAAACTTAACCT	0.327													7	34	---	---	---	---					
LRRC37A2	474170	broad.mit.edu	37	17	44626186	44626186	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr17:44626186delG	ENST00000576629.1	+	10	4176	c.3681delG	c.(3679-3681)gcfs	p.A1227fs	ARL17A_ENST00000337845.7_Intron|LRRC37A2_ENST00000333412.3_Frame_Shift_Del_p.A1227fs|ARL17A_ENST00000329240.4_Intron|ARL17A_ENST00000573185.1_Intron|ARL17A_ENST00000445552.2_Intron			A6NM11	L37A2_HUMAN	leucine rich repeat containing 37, member A2	1227						integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|pancreas(4)|prostate(2)	15		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		AGAAGTTAGCGGGAAACGCCG	0.592													23	184	---	---	---	---					
PPP6R1	22870	broad.mit.edu	37	19	55748038	55748039	+	Frame_Shift_Ins	INS	-	-	C			TCGA-D3-A1Q1-06A-21D-A196-08	TCGA-D3-A1Q1-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a0583407-712d-46f3-8c4e-4eeaa0149087	628778f0-a013-498a-938a-bea1361add23	g.chr19:55748038_55748039insC	ENST00000412770.2	-	17	2526_2527	c.1960_1961insG	c.(1960-1962)ccgfs	p.P654fs	PPP6R1_ENST00000587283.1_Frame_Shift_Ins_p.P654fs	NM_014931.3	NP_055746.3	Q9UPN7	PP6R1_HUMAN	protein phosphatase 6, regulatory subunit 1	654	Glu-rich.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding			breast(1)	1						GCCCAGACGGGCCCCCCTGGCC	0.649													7	21	---	---	---	---