Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
WDR16	146845	broad.mit.edu	37	17	9515650	9515650	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr17:9515650C>G	ENST00000352665.5	+	8	948	c.879C>G	c.(877-879)atC>atG	p.I293M	WDR16_ENST00000396219.3_Missense_Mutation_p.I225M|WDR16_ENST00000299764.5_Missense_Mutation_p.I303M	NM_145054.4	NP_659491.4	Q8N1V2	WDR16_HUMAN	WD repeat domain 16	293						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31						AAGGCGGCATCACTTCTATCA	0.433000													19	46					0	0	8.00594e-06	0	0
ABCA5	23461	broad.mit.edu	37	17	67251966	67251966	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr17:67251966A>G	ENST00000392676.3	-	30	3948	c.3884T>C	c.(3883-3885)tTg>tCg	p.L1295S	ABCA5_ENST00000392677.2_Missense_Mutation_p.L1296S|ABCA5_ENST00000588877.1_Missense_Mutation_p.L1295S			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	1295	ABC transporter 2.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					TTCTTTATGCAAATTGCTGAC	0.294000													19	54					0	0	8.00594e-06	0	0
FAT4	79633	broad.mit.edu	37	4	126371456	126371456	+	Silent	SNP	T	T	C			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr4:126371456T>C	ENST00000394329.3	+	9	9298	c.9285T>C	c.(9283-9285)agT>agC	p.S3095S	FAT4_ENST00000335110.5_Silent_p.S1393S	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3095	Cadherin 30.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GCCACATGAGTGCAACCATCC	0.443000													18	38					0	0	1.15919e-05	0	0
ALDOC	230	broad.mit.edu	37	17	26901545	26901545	+	Silent	SNP	G	G	A			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr17:26901545G>A	ENST00000226253.4	-	6	1066	c.591C>T	c.(589-591)caC>caT	p.H197H	ALDOC_ENST00000395321.2_Silent_p.H197H|ALDOC_ENST00000395319.3_Intron	NM_005165.2	NP_005156.1	P09972	ALDOC_HUMAN	aldolase C, fructose-bisphosphate	197					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11	Lung NSC(42;0.00431)					GTTTGAGGTCGTGGTCTCCAT	0.522000													47	90					0	0	2.47226e-05	0	0
TLL1	7092	broad.mit.edu	37	4	166916261	166916261	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr4:166916261A>G	ENST00000061240.2	+	5	1210	c.563A>G	c.(562-564)cAc>cGc	p.H188R	TLL1_ENST00000513213.1_Missense_Mutation_p.H188R|TLL1_ENST00000507499.1_Missense_Mutation_p.H188R	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	188	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TGGGAAAAGCACACATGTGTG	0.443000													53	102					0	0	2.47226e-05	0	0
PARD3	56288	broad.mit.edu	37	10	34759192	34759192	+	Splice_Site	SNP	C	C	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr10:34759192C>T	ENST00000374789.3	-	4	729		c.e4-1		PARD3_ENST00000545260.1_Splice_Site|PARD3_ENST00000374776.1_Splice_Site|PARD3_ENST00000374790.3_Splice_Site|PARD3_ENST00000350537.4_Splice_Site|PARD3_ENST00000545693.1_Splice_Site|PARD3_ENST00000346874.4_Splice_Site|PARD3_ENST00000374788.3_Splice_Site|PARD3_ENST00000340077.5_Splice_Site|PARD3_ENST00000374773.1_Splice_Site|PARD3_ENST00000374794.3_Splice_Site	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				AGAGGCATATCTGTAAACACA	0.388000													27	68					0	0	2.90539e-05	0	0
C1orf106	55765	broad.mit.edu	37	1	200869294	200869294	+	Silent	SNP	T	T	A			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr1:200869294T>A	ENST00000367342.4	+	4	698	c.498T>A	c.(496-498)gtT>gtA	p.V166V	C1orf106_ENST00000413687.2_Silent_p.V81V	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	166										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						CCCCCAAGGTTCGCCGCAGGA	0.617000													15	18					0	0	7.07596e-05	0	0
RBM6	10180	broad.mit.edu	37	3	50106193	50106193	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr3:50106193G>A	ENST00000443081.1	+	18	3537	c.2618G>A	c.(2617-2619)cGa>cAa	p.R873Q	RBM6_ENST00000422955.1_Missense_Mutation_p.R483Q|RBM6_ENST00000421682.1_5'UTR|RBM6_ENST00000539992.1_Missense_Mutation_p.R347Q|RBM6_ENST00000266022.4_Missense_Mutation_p.R1005Q|RBM6_ENST00000442092.1_Missense_Mutation_p.R483Q			P78332	RBM6_HUMAN	RNA binding motif protein 6	1005					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		AGGAGAGAACGAGAGGTAAAC	0.433000													13	35					0	0	3.45872e-05	0	0
SLC4A4	8671	broad.mit.edu	37	4	72420881	72420881	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr4:72420881G>C	ENST00000340595.3	+	18	2783	c.2587G>C	c.(2587-2589)Ggt>Cgt	p.G863R	SLC4A4_ENST00000425175.1_Missense_Mutation_p.G907R|SLC4A4_ENST00000351898.6_Missense_Mutation_p.G823R|SLC4A4_ENST00000264485.5_Missense_Mutation_p.G907R	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	907						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TGTACTCTATGGTGTGTTCCT	0.328000													6	309					0	0	2.0095e-06	0	0
PDS5B	23047	broad.mit.edu	37	13	33268438	33268438	+	Silent	SNP	C	C	A			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr13:33268438C>A	ENST00000315596.10	+	14	1734	c.1548C>A	c.(1546-1548)ccC>ccA	p.P516P		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	516					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		TTAAGCAACCCAAAGTAAGTA	0.303000													7	190					5.18039e-06	0.00118263	5.18039e-06	1	0
PI4KA	5297	broad.mit.edu	37	22	21080785	21080785	+	Silent	SNP	C	C	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr22:21080785C>T	ENST00000255882.6	-	42	5072	c.4986G>A	c.(4984-4986)agG>agA	p.R1662R	PI4KA_ENST00000572273.1_Silent_p.R1604R|PI4KA_ENST00000414196.3_Silent_p.R414R	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	1604	Pleckstrin homology (PH) domain conferring phosphoinositide binding specificity (By similarity).				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CCTTGTCGTACCTGAGGGCCT	0.597000													11	50					0	0	6.40141e-05	0	0
ELK4	2005	broad.mit.edu	37	1	205588103	205588103	+	Silent	SNP	A	A	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr1:205588103A>G	ENST00000357992.4	-	4	1518	c.1179T>C	c.(1177-1179)ggT>ggC	p.G393G		NM_001973.3	NP_001964.2			ELK4, ETS-domain protein (SRF accessory protein 1)										SLC45A3/ELK4(18)	breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	12	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			GTGTGTTAGCACCTTGCAGTC	0.458000			T	SLC45A3	prostate								12	40					0	0	1.49906e-05	0	0
SLC22A4	6583	broad.mit.edu	37	5	131670426	131670426	+	Silent	SNP	G	G	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr5:131670426G>T	ENST00000200652.3	+	7	1236	c.1062G>T	c.(1060-1062)gtG>gtT	p.V354V	AC034220.3_ENST00000417795.1_RNA|AC034220.3_ENST00000437091.1_RNA	NM_003059.2	NP_003050.2	Q9H015	S22A4_HUMAN	solute carrier family 22 (organic cation/zwitterion transporter), member 4	354					body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|urinary_tract(1)	16		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	TGACCTCAGTGGGTTACTTTG	0.403000													17	489					3.83957e-06	0.000890906	4.16121e-05	1	0
GCOM1	145781	broad.mit.edu	37	15	57913897	57913897	+	Splice_Site	SNP	C	C	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr15:57913897C>G	ENST00000574161.1	+	4	529	c.411_splice	c.e4+1	p.S137_splice	POLR2M_ENST00000380563.2_Intron|MYZAP_ENST00000267853.5_Splice_Site_p.S137_splice|MYZAP_ENST00000380565.4_Splice_Site_p.S137_splice|GCOM1_ENST00000587652.1_Splice_Site_p.S137_splice|GCOM1_ENST00000572390.1_Splice_Site_p.S137_splice|GCOM1_ENST00000396180.1_Intron|GCOM1_ENST00000380560.2_Intron|GCOM1_ENST00000380568.3_Splice_Site_p.S137_splice|GCOM1_ENST00000380569.2_Splice_Site_p.S137_splice|GCOM1_ENST00000380561.2_Intron	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		137					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						CAGGAACTATCAGTAAGTCAT	0.468000													11	100					0	0	5.50884e-06	0	0
NUP37	79023	broad.mit.edu	37	12	102512168	102512168	+	Silent	SNP	A	A	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr12:102512168A>G	ENST00000552283.1	-	2	268	c.129T>C	c.(127-129)taT>taC	p.Y43Y	NUP37_ENST00000543021.1_5'UTR|NUP37_ENST00000251074.1_Silent_p.Y43Y			Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	43					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			endometrium(3)|large_intestine(3)|lung(10)|ovary(1)	17						CAATGACCACATAATTATTGC	0.388000													26	113					0	0	1.32003e-05	0	0
ITGA3	3675	broad.mit.edu	37	17	48157685	48157685	+	Silent	SNP	C	C	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr17:48157685C>T	ENST00000320031.8	+	22	3096	c.2766C>T	c.(2764-2766)ccC>ccT	p.P922P	ITGA3_ENST00000007722.7_Silent_p.P922P	NM_002204.2|NM_005501.2	NP_002195.1|NP_005492.1	P26006	ITA3_HUMAN	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	922					blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	31						CTGATGCCCCCGTTGTCACCA	0.602000													12	5					0	0	5.01169e-05	0	0
ESD	2098	broad.mit.edu	37	13	47365541	47365541	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr13:47365541A>G	ENST00000378720.3	-	3	190	c.8T>C	c.(7-9)tTg>tCg	p.L3S	ESD_ENST00000378697.1_5'UTR|ESD_ENST00000495654.1_5'UTR	NM_001984.1	NP_001975.1	P10768	ESTD_HUMAN	esterase D	3						cytoplasmic membrane-bounded vesicle	carboxylesterase activity|S-formylglutathione hydrolase activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)	9		all_lung(13;3.54e-08)|Lung NSC(96;9.1e-06)|Breast(56;0.000148)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;2.66e-05)	Glutathione(DB00143)	AATCTGCTTCAATGCCATTCT	0.313000													31	57					0	0	1.48458e-05	0	0
ITGAV	3685	broad.mit.edu	37	2	187511592	187511592	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr2:187511592A>T	ENST00000261023.3	+	13	1613	c.1339A>T	c.(1339-1341)Aat>Tat	p.N447Y	AC017101.10_ENST00000453665.1_RNA|ITGAV_ENST00000374907.3_Missense_Mutation_p.N411Y|ITGAV_ENST00000433736.2_Missense_Mutation_p.N401Y	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	447					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		TATAGACAAAAATGGATATCC	0.398000													8	14					0	0	1.12685e-05	0	0
NMUR2	56923	broad.mit.edu	37	5	151771827	151771827	+	Silent	SNP	A	A	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr5:151771827A>G	ENST00000255262.3	-	4	1338	c.1173T>C	c.(1171-1173)tcT>tcC	p.S391S		NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	391					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			CTGGGAGGTGAGAGTTGTGCA	0.478000													8	293					0	0	2.17888e-05	0	0
ZBTB20	26137	broad.mit.edu	37	3	114058118	114058118	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr3:114058118G>A	ENST00000462705.1	-	12	2562	c.1741C>T	c.(1741-1743)Cgc>Tgc	p.R581C	ZBTB20_ENST00000481632.1_Missense_Mutation_p.R581C|ZBTB20_ENST00000474710.1_Missense_Mutation_p.R654C|ZBTB20_ENST00000471418.1_Missense_Mutation_p.R581C|ZBTB20_ENST00000357258.3_Missense_Mutation_p.R581C|ZBTB20_ENST00000393785.2_Missense_Mutation_p.R581C|ZBTB20_ENST00000464560.1_Missense_Mutation_p.R581C	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	654					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CGGTGGAGGCGCATGTGCACG	0.552000													35	74					0	0	7.51294e-05	0	0
CLTCL1	8218	broad.mit.edu	37	22	19178884	19178884	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr22:19178884T>C	ENST00000263200.10	-	27	4327	c.4255A>G	c.(4255-4257)Atc>Gtc	p.I1419V	CLTCL1_ENST00000353891.5_Missense_Mutation_p.I1419V|CLTCL1_ENST00000427926.1_Missense_Mutation_p.I1419V|CLTCL1_ENST00000442042.2_5'UTR	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	1419	Heavy chain arm.|Involved in binding clathrin light chain (By similarity).|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					AGGTCATTGATGAGCAGTGGT	0.527000			T	?	ALCL								5	59					0	0	2.0095e-06	0	0
SLC16A1	6566	broad.mit.edu	37	1	113464617	113464617	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr1:113464617A>T	ENST00000538576.1	-	3	1187	c.356T>A	c.(355-357)aTt>aAt	p.I119N	SLC16A1_ENST00000369626.3_Missense_Mutation_p.I119N|SLC16A1_ENST00000433570.4_Missense_Mutation_p.I119N	NM_001166496.1	NP_001159968.1	P53985	MOT1_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 1	119					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|urinary_tract(1)	20	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	CTCACCTCCAATGACTCCAAT	0.413000													14	54					0	0	7.07596e-05	0	0
C16orf78	123970	broad.mit.edu	37	16	49407922	49407922	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr16:49407922A>C	ENST00000299191.3	+	1	189	c.72A>C	c.(70-72)gaA>gaC	p.E24D		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	24										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						AGACTGCTGAAGATAGGCGCA	0.517000													21	70					0	0	4.16121e-05	0	0
FLT1	2321	broad.mit.edu	37	13	29005390	29005390	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr13:29005390T>G	ENST00000282397.4	-	7	1122	c.871A>C	c.(871-873)Ata>Cta	p.I291L	FLT1_ENST00000541932.1_Missense_Mutation_p.I291L|FLT1_ENST00000539099.1_Missense_Mutation_p.I291L	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	291	Ig-like C2-type 3.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CTGTAGAATATGTTGGCATGG	0.368000													39	53					0	0	1.39061e-05	0	0
SEMA6B	10501	broad.mit.edu	37	19	4548389	4548389	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr19:4548389A>G	ENST00000586582.1	-	13	1650	c.1340T>C	c.(1339-1341)cTg>cCg	p.L447P	SEMA6B_ENST00000586965.1_Missense_Mutation_p.L447P|SEMA6B_ENST00000301293.3_Missense_Mutation_p.L447P	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	447	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCAGAACCCAGGAAGACAAC	0.662000													5	26					0	0	1.23904e-05	0	0
KCNMA1	3778	broad.mit.edu	37	10	78943241	78943241	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr10:78943241A>G	ENST00000286627.5	-	5	1698	c.746T>C	c.(745-747)gTa>gCa	p.V249A	KCNMA1_ENST00000354353.5_Missense_Mutation_p.V249A|KCNMA1_ENST00000372443.1_Missense_Mutation_p.V249A|KCNMA1_ENST00000286628.8_Missense_Mutation_p.V249A|KCNMA1_ENST00000406533.3_Missense_Mutation_p.V249A|KCNMA1_ENST00000404771.3_Missense_Mutation_p.V249A|KCNMA1_ENST00000404857.1_Missense_Mutation_p.V249A|KCNMA1_ENST00000372440.1_Missense_Mutation_p.V249A	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	249					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	GAAATCCACTACAGAGTTCAC	0.448000													5	17					0	0	1.23904e-05	0	0
TLE4	7091	broad.mit.edu	37	9	82321762	82321762	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr9:82321762C>G	ENST00000376520.4	+	11	1712	c.884C>G	c.(883-885)tCt>tGt	p.S295C	TLE4_ENST00000376544.3_Intron|TLE4_ENST00000376552.2_Missense_Mutation_p.S295C|TLE4_ENST00000265284.6_Missense_Mutation_p.S270C|TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000376537.4_Missense_Mutation_p.S295C			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						AGTCCAGCCTCTATTGCATCT	0.522000													50	89					0	0	2.47226e-05	0	0
ZNF721	170960	broad.mit.edu	37	4	435871	435871	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr4:435871G>C	ENST00000338977.5	-	2	2397	c.2349C>G	c.(2347-2349)agC>agG	p.S783R	ABCA11P_ENST00000451020.2_RNA|ZNF721_ENST00000507078.1_Intron|ZNF721_ENST00000511833.2_Missense_Mutation_p.S795R|ZNF721_ENST00000506646.1_Intron					zinc finger protein 721											endometrium(2)|kidney(2)|large_intestine(15)|lung(6)|ovary(1)|skin(1)|stomach(5)|urinary_tract(1)	33						GTTTAGCAAAGCTTGAGGATG	0.368000													15	40					0	0	3.45872e-05	0	0
BSN	8927	broad.mit.edu	37	3	49693606	49693606	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr3:49693606T>C	ENST00000296452.4	+	5	6731	c.6617T>C	c.(6616-6618)cTg>cCg	p.L2206P		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2206					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCTGCAACACTGCCCATCACC	0.582000													11	11					0	0	3.86212e-05	0	0
MYH1	4619	broad.mit.edu	37	17	10408756	10408756	+	Silent	SNP	G	G	A			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr17:10408756G>A	ENST00000226207.5	-	20	2341	c.2247C>T	c.(2245-2247)ctC>ctT	p.L749L	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	749	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity	p.L750M(2)		NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TGGACCCCAGGAGCTTCTCTG	0.403000													20	42					0	0	1.15919e-05	0	0
HSPA6	3310	broad.mit.edu	37	1	161494813	161494813	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr1:161494813C>T	ENST00000309758.4	+	1	778	c.365C>T	c.(364-366)tCg>tTg	p.S122L		NM_002155.3	NP_002146.2	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	122					response to unfolded protein		ATP binding			endometrium(3)|large_intestine(5)|lung(9)|prostate(2)|skin(2)	21	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GAGGAGATCTCGTCCATGGTG	0.627000													5	25					0	0	2.0095e-06	0	0
DUXA	503835	broad.mit.edu	37	19	57666738	57666738	+	Silent	SNP	A	A	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr19:57666738A>T	ENST00000554048.2	-	5	440	c.441T>A	c.(439-441)atT>atA	p.I147I		NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A	147						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		TTTGGAACCAAATCTAAGTGG	0.373000													9	38					0	0	1.12685e-05	0	0
GBA3	57733	broad.mit.edu	37	4	22729244	22729244	+	RNA	SNP	A	A	C			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr4:22729244A>C	ENST00000511446.1	+	0	61				GBA3_ENST00000503442.1_RNA|GBA3_ENST00000508166.1_RNA	NM_001277225.1	NP_001264154.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						CAACAAGCAAAAAAGGAGTCT	0.413000													33	178					0	0	1.48458e-05	0	0
PCDH20	64881	broad.mit.edu	37	13	61986652	61986652	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr13:61986652T>A	ENST00000409186.1	-	5	3685	c.1580A>T	c.(1579-1581)gAt>gTt	p.D527V	PCDH20_ENST00000409204.4_Missense_Mutation_p.D527V			Q8N6Y1	PCD20_HUMAN	protocadherin 20	500	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		ATCATTGTCATCTAAAAGTTG	0.403000													27	118					0	0	2.25844e-05	0	0
SMCHD1	23347	broad.mit.edu	37	18	2760728	2760728	+	Silent	SNP	C	C	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr18:2760728C>T	ENST00000320876.6	+	35	4763	c.4425C>T	c.(4423-4425)aaC>aaT	p.N1475N	RP11-703M24.5_ENST00000583546.1_RNA|SMCHD1_ENST00000261598.8_Silent_p.N1475N	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1475					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						ATATTCTCAACAGTGAACAGG	0.294000													13	52					0	0	1.49906e-05	0	0
PI4KA	5297	broad.mit.edu	37	22	21174140	21174140	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr22:21174140G>A	ENST00000255882.6	-	6	664	c.578C>T	c.(577-579)gCa>gTa	p.A193V	PI4KA_ENST00000572273.1_Missense_Mutation_p.A135V	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	135					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			ACGCCCAAATGCTCGCGAGAT	0.443000													33	2115					0	0	5.01169e-05	0	0
HS3ST3A1	9955	broad.mit.edu	37	17	13399557	13399557	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr17:13399557T>G	ENST00000284110.1	-	2	1975	c.1178A>C	c.(1177-1179)aAg>aCg	p.K393T	HS3ST3A1_ENST00000578576.1_Missense_Mutation_p.K191T	NM_006042.1	NP_006033.1	Q9Y663	HS3SA_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	393						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_lung(20;0.114)		UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTGGTAGAACTTGAGGTTGAA	0.478000													13	45					0	0	8.00594e-06	0	0
MAGI2	9863	broad.mit.edu	37	7	77973259	77973259	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr7:77973259C>T	ENST00000354212.4	-	9	1497	c.1244G>A	c.(1243-1245)cGg>cAg	p.R415Q	MAGI2_ENST00000419488.1_Missense_Mutation_p.R415Q|MAGI2_ENST00000535697.1_Missense_Mutation_p.R252Q|MAGI2_ENST00000536571.1_Missense_Mutation_p.R247Q|MAGI2_ENST00000522391.1_Missense_Mutation_p.R415Q	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	415						cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GGATGCATCCCGGGTGAAGAG	0.453000													8	36					0	0	2.17888e-05	0	0
P2RX6	9127	broad.mit.edu	37	22	21369573	21369573	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr22:21369573G>T	ENST00000413302.2	+	1	258	c.110G>T	c.(109-111)cGg>cTg	p.R37L	P2RX6_ENST00000591411.1_Intron|P2RX6_ENST00000402329.3_Intron|P2RX6_ENST00000401443.1_Intron|P2RX6_ENST00000443995.3_5'UTR|P2RX6_ENST00000336296.2_Missense_Mutation_p.R27L			O15547	P2RX6_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 6	37					muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity										AGGAACTGGCGGGTGGGCGCC	0.597000													38	2094					3.65163e-15	8.76019e-13	1.7367e-05	1	0
CHMP1B	57132	broad.mit.edu	37	18	11852107	11852107	+	Silent	SNP	G	G	A			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr18:11852107G>A	ENST00000526991.2	+	1	713	c.597G>A	c.(595-597)gtG>gtA	p.V199V	RP11-78A19.3_ENST00000586474.1_RNA|GNAL_ENST00000535121.1_Intron|GNAL_ENST00000269162.5_Intron|GNAL_ENST00000423027.3_Intron|GNAL_ENST00000334049.6_Intron	NM_020412.4	NP_065145.2	Q7LBR1	CHM1B_HUMAN	charged multivesicular body protein 1B	199	Interaction with SPAST.|Interaction with VPS4B.|Interaction with VTA1.				cell cycle|cell division|protein transport	cytosol|late endosome membrane	protein domain specific binding			endometrium(1)|lung(1)|urinary_tract(1)	3						GGGATCAAGTGTGACGGCAGA	0.587000													5	8					0	0	3.59834e-05	0	0
FRG1B	284802	broad.mit.edu	37	20	29625875	29625875	+	Missense_Mutation	SNP	T	T	C	rs143761036	by1000genomes	TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr20:29625875T>C	ENST00000278882.3	+	5	499	c.119T>C	c.(118-120)aTc>aCc	p.I40T	FRG1B_ENST00000439954.2_Missense_Mutation_p.I45T|FRG1B_ENST00000358464.4_Missense_Mutation_p.I40T														p.I40T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGTACAGAATCGCCCTGAAA	0.358000													5	71					0	0	3.59834e-05	0	0
USP41	373856	broad.mit.edu	37	22	20721019	20721019	+	Silent	SNP	C	C	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr22:20721019C>T	ENST00000454608.2	-	10	728	c.729G>A	c.(727-729)ttG>ttA	p.L243L	USP41_ENST00000486536.2_5'UTR					ubiquitin specific peptidase 41											endometrium(1)|kidney(1)|lung(2)|skin(1)	5						GGGTCAGCTTCAAGACCTGAA	0.488000													118	102					0	0	2.47226e-05	0	0
HEPHL1	341208	broad.mit.edu	37	11	93796824	93796824	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr11:93796824A>G	ENST00000315765.9	+	3	574	c.566A>G	c.(565-567)cAc>cGc	p.H189R		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	189	Plastocyanin-like 1.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TACCATTCGCACATCGACGCC	0.537000													11	58					0	0	1.49906e-05	0	0
ZNF711	7552	broad.mit.edu	37	X	84526177	84526177	+	Silent	SNP	A	A	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chrX:84526177A>G	ENST00000360700.4	+	10	2653	c.1767A>G	c.(1765-1767)gcA>gcG	p.A589A	ZNF711_ENST00000373165.3_Silent_p.A543A|ZNF711_ENST00000276123.3_Silent_p.A543A|ZNF711_ENST00000395402.1_Silent_p.A551A|ZNF711_ENST00000542798.1_Silent_p.A385A			Q9Y462	ZN711_HUMAN	zinc finger protein 711	543					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						TCAGGTGTGCAGATCAATCAA	0.403000													7	8					0	0	5.18039e-06	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72658501	72658501	+	RNA	SNP	T	T	C			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr7:72658501T>C	ENST00000425256.1	-	0	1410					NR_002164.1																						tctcatcgattgcgatagaat	0.458000													4	49					0	0	1.23904e-05	0	0
TDRD5	163589	broad.mit.edu	37	1	179631268	179631268	+	Silent	SNP	G	G	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr1:179631268G>T	ENST00000444136.1	+	15	2602	c.2352G>T	c.(2350-2352)ctG>ctT	p.L784L	TDRD5_ENST00000294848.8_Silent_p.L730L|TDRD5_ENST00000367614.1_Silent_p.L730L	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	781					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding	p.L730L(1)		NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						TGCCATGCCTGGAGTCAGTGA	0.403000													30	72					3.28013e-08	7.73783e-06	2.31628e-05	1	0
TPTE	7179	broad.mit.edu	37	21	10934960	10934960	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr21:10934960T>C	ENST00000298232.7	-	14	1146	c.779A>G	c.(778-780)cAc>cGc	p.H260R	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Missense_Mutation_p.H278R|TPTE_ENST00000342420.5_Missense_Mutation_p.H240R	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	278	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GACTCGATAGTGGTTTCGGTG	0.343000													19	155					0	0	1.64113e-05	0	0
KIT	3815	broad.mit.edu	37	4	55594221	55594221	+	Missense_Mutation	SNP	A	A	G	rs121913512		TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr4:55594221A>G	ENST00000288135.5	+	13	2021	c.1924A>G	c.(1924-1926)Aaa>Gaa	p.K642E		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	642	Protein kinase.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.K642E(25)|p.K642Q(1)		NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GTCTGAACTCAAAGTCCTGAG	0.438000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				312	61					0	0	2.47226e-05	0	0
CASK	8573	broad.mit.edu	37	X	41646527	41646527	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chrX:41646527C>G	ENST00000318588.9	-	3	227	c.182G>C	c.(181-183)cGg>cCg	p.R61P	CASK_ENST00000421587.2_Missense_Mutation_p.R61P|CASK_ENST00000378166.4_Missense_Mutation_p.R61P|CASK_ENST00000442742.2_Missense_Mutation_p.R61P|CASK_ENST00000378163.1_Missense_Mutation_p.R61P|CASK_ENST00000378158.1_Missense_Mutation_p.R61P|CASK_ENST00000361962.4_Missense_Mutation_p.R61P|CASK_ENST00000378154.1_Missense_Mutation_p.R61P			O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	61	Protein kinase.				cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|ovary(3)|prostate(1)|stomach(1)	32						ACTGGCTTCCCGCTTTAGATC	0.363000													4	57					0	0	2.56e-06	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20483995	20483995	+	Splice_Site	SNP	C	C	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr20:20483995C>T	ENST00000202677.6	-	35	5350	c.5208_splice	c.e35+1	p.K1736_splice		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	1736	Rap-GAP.				activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						GACCCCTTACCTTTTTGGTGA	0.517000													16	23					0	0	8.00594e-06	0	0
KIAA1324	57535	broad.mit.edu	37	1	109735314	109735314	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr1:109735314C>T	ENST00000369939.3	+	14	1948	c.1765C>T	c.(1765-1767)Cgt>Tgt	p.R589C	KIAA1324_ENST00000369938.1_3'UTR|KIAA1324_ENST00000529753.1_Missense_Mutation_p.R502C	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	589					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		CTCCTACTGCCGTCCCTGTGC	0.522000													106	257					0	0	2.47226e-05	0	0
IGFL3	388555	broad.mit.edu	37	19	46627194	46627194	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr19:46627194A>G	ENST00000341415.2	-	3	323	c.299T>C	c.(298-300)cTg>cCg	p.L100P	AC007193.6_ENST00000597989.1_lincRNA	NM_207393.1	NP_997276.1	Q6UXB1	IGFL3_HUMAN	IGF-like family member 3	100						extracellular region	protein binding			endometrium(1)|large_intestine(1)|lung(5)	7		Ovarian(192;0.0175)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00473)|GBM - Glioblastoma multiforme(486;0.0149)|Epithelial(262;0.239)		CTTCATACCCAGAACCCTCAA	0.542000													7	120					0	0	5.18039e-06	0	0
APBB1IP	54518	broad.mit.edu	37	10	26790050	26790050	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr10:26790050T>C	ENST00000356785.4	+	5	696	c.463T>C	c.(463-465)Tgg>Cgg	p.W155R	APBB1IP_ENST00000376236.4_Intron			Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	0	Poly-Glu.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium		p.?(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						GGTAAGTATGTGGGACCAGAG	0.488000													30	50					0	0	3.70037e-05	0	0
TTF1	7270	broad.mit.edu	37	9	135273619	135273619	+	Silent	SNP	A	A	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr9:135273619A>G	ENST00000334270.2	-	4	1725	c.1686T>C	c.(1684-1686)agT>agC	p.S562S		NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	562					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		GCTTGTCTGCACTCTCAATGC	0.383000													13	39					0	0	9.31168e-06	0	0
ASCC3	10973	broad.mit.edu	37	6	101127554	101127554	+	Silent	SNP	A	A	G			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr6:101127554A>G	ENST00000369162.2	-	14	2570	c.2226T>C	c.(2224-2226)tgT>tgC	p.C742C		NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	742	Helicase C-terminal 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		GAATATGGCCACAATTTTTTG	0.368000													5	84					0	0	1.23904e-05	0	0
AHCTF1	25909	broad.mit.edu	37	1	247019110	247019111	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr1:247019110_247019111delAC	ENST00000366508.1	-	31	4516_4517	c.4380_4381delGT	c.(4378-4383)aaccfs	p.KS1460fs	AHCTF1_ENST00000391829.2_Frame_Shift_Del_p.KS1425fs|AHCTF1_ENST00000470300.1_5'UTR|AHCTF1_ENST00000326225.3_Frame_Shift_Del_p.KS1434fs			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	1425	Mediates transcriptional activity (By similarity).|Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			GGTACCTTGGACTTCTGGGTGA	0.371													33	86	---	---	---	---					
EIF2AK3	9451	broad.mit.edu	37	2	88874269	88874270	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr2:88874269_88874270delCT	ENST00000303236.3	-	13	3032_3033	c.2731_2732delAG	c.(2731-2733)gfs	p.R911fs	EIF2AK3_ENST00000419748.1_Frame_Shift_Del_p.R760fs|AC104134.2_ENST00000413234.1_RNA|EIF2AK3_ENST00000470706.1_5'UTR	NM_004836.5	NP_004827.4	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 3	911	Protein kinase.				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						ACACACGCTCCTCTCTCTCTCC	0.465													10	601	---	---	---	---					
GCC2	9648	broad.mit.edu	37	2	109087883	109087884	+	Frame_Shift_Ins	INS	-	-	A			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr2:109087883_109087884insA	ENST00000309863.6	+	6	2812_2813	c.2098_2099insA	c.(2098-2100)aaafs	p.K700fs		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	700					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						ACTCAGTTCAGAAAAAAAACAG	0.307													8	382	---	---	---	---					
ITGA4	3676	broad.mit.edu	37	2	182343491	182343492	+	Frame_Shift_Ins	INS	-	-	A			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr2:182343491_182343492insA	ENST00000397033.2	+	5	994_995	c.564_565insA	c.(562-567)gtaaaafs	p.VK188fs	ITGA4_ENST00000478440.1_3'UTR	NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	188					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TAGATTATGTGAAAAAATTTGG	0.243													9	29	---	---	---	---					
SLITRK3	22865	broad.mit.edu	37	3	164906282	164906282	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr3:164906282delA	ENST00000475390.1	-	2	2780	c.2337delT	c.(2335-2337)ggfs	p.G779fs	SLITRK3_ENST00000241274.3_Frame_Shift_Del_p.G779fs			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	779						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						GTGTCCCTGGACCCCCACGTT	0.562										HNSCC(40;0.11)			14	53	---	---	---	---					
FIP1L1	81608	broad.mit.edu	37	4	54319248	54319249	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr4:54319248_54319249delAG	ENST00000337488.6	+	16	1641_1642	c.1447_1448delAG	c.(1447-1449)afs	p.R483fs	FIP1L1_ENST00000358575.5_Frame_Shift_Del_p.R477fs|FIP1L1_ENST00000306932.6_Frame_Shift_Del_p.R409fs|FIP1L1_ENST00000507166.1_Intron	NM_030917.3	NP_112179.2	Q6UN15	FIP1_HUMAN	factor interacting with PAPOLA and CPSF1	483	Arg-rich.|Glu-rich.|Sufficient for interaction with CPSF1 and CSTF3.				mRNA processing	nucleus	RNA binding	p.R487fs*3(2)		large_intestine(3)|liver(1)|ovary(1)|skin(1)	6			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			agaACGCACCAGAGAGAGAGAG	0.470			T	PDGFRA	idiopathic hypereosinophilic syndrome								8	120	---	---	---	---					
CLOCK	9575	broad.mit.edu	37	4	56336954	56336954	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr4:56336954delA	ENST00000309964.4	-	7	618	c.368delT	c.(367-369)tafs	p.L123fs	CLOCK_ENST00000513440.1_Frame_Shift_Del_p.L123fs|CLOCK_ENST00000381322.1_Frame_Shift_Del_p.L123fs	NM_004898.3	NP_004889.1	O15516	CLOCK_HUMAN	clock circadian regulator	123	PAS 1.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity	p.L123fs*1(2)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(8)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			CATGATTGCTAAAAAAAAACC	0.289													7	460	---	---	---	---					
CDH10	1008	broad.mit.edu	37	5	24492973	24492973	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr5:24492973delA	ENST00000264463.4	-	10	2084	c.1577delT	c.(1576-1578)tcfs	p.F526fs	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	526	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AGCTAAACTGAAAAAAAATTT	0.313										HNSCC(23;0.051)			14	3600	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102738793	102738794	+	RNA	INS	-	-	T	rs35342965	by1000genomes	TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr11:102738793_102738794insT	ENST00000532855.1	-	0	727_728							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TGAGGAACAAGTGGTGCCTAAG	0.416													5	11	---	---	---	---					
ENDOV	284131	broad.mit.edu	37	17	78397370	78397370	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr17:78397370delG	ENST00000518137.1	+	5	482	c.454delG	c.(454-456)ggfs	p.G152fs	ENDOV_ENST00000517795.1_5'UTR|ENDOV_ENST00000517295.2_Frame_Shift_Del_p.G69fs|ENDOV_ENST00000520367.1_Frame_Shift_Del_p.G107fs|ENDOV_ENST00000518644.1_Frame_Shift_Del_p.G69fs|ENDOV_ENST00000518901.1_5'UTR|ENDOV_ENST00000522751.1_5'UTR|ENDOV_ENST00000518907.1_5'UTR|ENDOV_ENST00000520284.1_5'UTR|ENDOV_ENST00000323854.5_Frame_Shift_Del_p.G107fs	NM_173627.3	NP_775898.2	Q8N8Q3	ENDOV_HUMAN	endonuclease V	152					DNA repair		endodeoxyribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding			endometrium(1)|lung(1)|pancreas(1)|prostate(1)	4						GCCGTGTGTTGGGGTGGCCAA	0.652								Direct reversal of damage					2	4	---	---	---	---					
SLC52A3	113278	broad.mit.edu	37	20	744613	744613	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr20:744613delC	ENST00000381944.3	-	3	843	c.602delG	c.(601-603)gafs	p.G201fs	SLC52A3_ENST00000217254.7_Frame_Shift_Del_p.G201fs|SLC52A3_ENST00000473664.1_Intron			Q9NQ40	RFT2_HUMAN	solute carrier family 52 (riboflavin transporter), member 3	201					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity										TGCTTCCATTCCGGGGAGGGC	0.587													2	4	---	---	---	---					
CRKL	1399	broad.mit.edu	37	22	21304075	21304075	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D3-A1Q3-06A-11D-A196-08	TCGA-D3-A1Q3-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0955adc-8469-48a3-a66e-b0059adda3a6	ea02a2db-bb1c-43b6-8977-7289dd750b3c	g.chr22:21304075delT	ENST00000354336.3	+	3	1363	c.854delT	c.(853-855)ctfs	p.L285fs		NM_005207.3	NP_005198.1	P46109	CRKL_HUMAN	v-crk avian sarcoma virus CT10 oncogene homolog-like	285	SH3 2.				JNK cascade|Ras protein signal transduction	cytosol	protein tyrosine kinase activity|SH3/SH2 adaptor activity|signal transducer activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)	14	all_cancers(11;1.16e-25)|all_epithelial(7;3.37e-24)|Lung NSC(8;7.25e-16)|all_lung(8;1.37e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.176)			CGCAAAGGGCTTTTCCCCTTT	0.468													8	2850	---	---	---	---