Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
G6PD	2539	broad.mit.edu	37	X	153774257	153774257	+	Silent	SNP	A	A	C			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chrX:153774257A>C	ENST00000393562.2	-	2	587	c.204T>G	c.(202-204)ggT>ggG	p.G68G	IKBKG_ENST00000369609.5_Intron|IKBKG_ENST00000369607.1_Intron|G6PD_ENST00000369620.2_Silent_p.G38G|G6PD_ENST00000393564.2_Silent_p.G38G|G6PD_ENST00000497281.1_5'UTR	NM_000402.3	NP_000393.4	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase	38			V -> M (in A(-) type I; class III; frequent in African population; dbSNP:rs1050828).		cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(3)|ovary(4)	18	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCACCGATGCACCCATGATGA	0.562000													37	139					0	0	7.43668e-06	0	0
CA4	762	broad.mit.edu	37	17	58235086	58235086	+	Silent	SNP	G	G	A			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr17:58235086G>A	ENST00000300900.4	+	5	549	c.450G>A	c.(448-450)tcG>tcA	p.S150S		NM_000717.3	NP_000708.1	P22748	CAH4_HUMAN	carbonic anhydrase IV	150					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(5)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	AGGGGACATCGAGGAATGTGA	0.592000													56	12					0	0	2.47226e-05	0	0
C4BPA	722	broad.mit.edu	37	1	207287557	207287557	+	Silent	SNP	C	C	T			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr1:207287557C>T	ENST00000367070.3	+	3	449	c.255C>T	c.(253-255)taC>taT	p.Y85Y		NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	85	Sushi 1.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						TCCCTGGCTACGTCAGATCCC	0.433000													16	46					0	0	3.52763e-06	0	0
CDSN	1041	broad.mit.edu	37	6	31084467	31084467	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr6:31084467G>A	ENST00000376288.2	-	2	951	c.925C>T	c.(925-927)Cca>Tca	p.P309S	PSORS1C1_ENST00000467107.1_3'UTR|PSORS1C1_ENST00000259881.9_Intron	NM_001264.4	NP_001255.3	Q15517	CDSN_HUMAN	corneodesmosin	309	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)	10						GTCATGCCTGGAACCAGATAA	0.547000													13	4					0	0	9.31168e-06	0	0
TAOK2	9344	broad.mit.edu	37	16	29998438	29998438	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr16:29998438C>T	ENST00000308893.4	+	16	3888	c.2845C>T	c.(2845-2847)Cat>Tat	p.H949Y	TAOK2_ENST00000279394.3_Intron|TAOK2_ENST00000416441.2_Missense_Mutation_p.H776Y|TAOK2_ENST00000543033.1_Missense_Mutation_p.H836Y	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	949	Leu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						ACTCCTGTCCCATGGCCTCCT	0.667000													39	79					0	0	2.47226e-05	0	0
ZNF7	7553	broad.mit.edu	37	8	146067043	146067043	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr8:146067043T>C	ENST00000528372.1	+	5	791	c.551T>C	c.(550-552)cTt>cCt	p.L184P	ZNF7_ENST00000325241.6_Missense_Mutation_p.L184P|ZNF7_ENST00000532393.1_3'UTR|ZNF7_ENST00000525266.1_Intron|ZNF7_ENST00000325217.5_Intron|ZNF7_ENST00000446747.2_Missense_Mutation_p.L195P|ZNF7_ENST00000529819.1_Intron|ZNF7_ENST00000544249.1_Missense_Mutation_p.L88P			P17097	ZNF7_HUMAN	zinc finger protein 7	184					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(5)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		TGTCAGCCTCTTGAAAGTCAG	0.537000													19	72					0	0	1.15919e-05	0	0
NCOA7	135112	broad.mit.edu	37	6	126211073	126211073	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr6:126211073A>G	ENST00000368357.3	+	10	2225	c.1873A>G	c.(1873-1875)Aat>Gat	p.N625D	NCOA7_ENST00000229634.9_Missense_Mutation_p.N510D|NCOA7_ENST00000392477.2_Missense_Mutation_p.N625D	NM_001199619.1|NM_001199620.1	NP_001186548.1|NP_001186549.1	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7	625					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(2)	39				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		ACAAATGGATAATAAATCTGA	0.373000													37	18					0	0	9.21781e-06	0	0
NAPA	8775	broad.mit.edu	37	19	47991567	47991567	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr19:47991567C>T	ENST00000263354.3	-	11	1165	c.866G>A	c.(865-867)gGc>gAc	p.G289D	NAPA-AS1_ENST00000593284.1_RNA|NAPA-AS1_ENST00000594367.1_RNA|NAPA_ENST00000595227.1_Missense_Mutation_p.G250D	NM_003827.3	NP_003818.2	P54920	SNAA_HUMAN	N-ethylmaleimide-sensitive factor attachment protein, alpha	289					cellular membrane fusion|intra-Golgi vesicle-mediated transport|post-Golgi vesicle-mediated transport	cytosol				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)	11		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000466)|all cancers(93;0.000739)|Epithelial(262;0.0168)|GBM - Glioblastoma multiforme(486;0.049)		CTCCTCATCGCCCTGGATGGT	0.622000													23	36					0	0	1.32003e-05	0	0
SMG1	23049	broad.mit.edu	37	16	18848644	18848644	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr16:18848644A>G	ENST00000446231.2	-	46	7947	c.7535T>C	c.(7534-7536)cTa>cCa	p.L2512P	SMG1_ENST00000389467.3_Missense_Mutation_p.L2512P			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	2512					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						TTCCTCCAGTAGTTTGCCCTG	0.428000													63	134					0	0	2.47226e-05	0	0
RGPD3	653489	broad.mit.edu	37	2	107073516	107073516	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr2:107073516T>C	ENST00000409886.3	-	4	403	c.316A>G	c.(316-318)Aaa>Gaa	p.K106E	RGPD3_ENST00000304514.7_Missense_Mutation_p.K106E	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	106					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						ACATCATTTTTACAAAGCAAT	0.328000													61	104					0	0	2.47226e-05	0	0
BAGE2	85319	broad.mit.edu	37	21	11058322	11058322	+	RNA	SNP	C	C	T			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr21:11058322C>T	ENST00000470054.1	-	0	325									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAATGCACATCGCTGAAAGGG	0.383000													7	169					0	0	1.12685e-05	0	0
LILRB4	11006	broad.mit.edu	37	19	55179198	55179198	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr19:55179198A>G	ENST00000391736.1	+	13	1469	c.1154A>G	c.(1153-1155)gAc>gGc	p.D385G	LILRB4_ENST00000391733.3_Missense_Mutation_p.D386G|LILRB4_ENST00000391734.3_Intron|LILRB4_ENST00000430952.2_Missense_Mutation_p.D384G|LILRB4_ENST00000270452.2_Missense_Mutation_p.D385G	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	385						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		GAATTCCTGGACACAAAGGAC	0.587000													4	22					0	0	1.23904e-05	0	0
MYH1	4619	broad.mit.edu	37	17	10415496	10415496	+	Silent	SNP	T	T	C			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr17:10415496T>C	ENST00000226207.5	-	13	1255	c.1161A>G	c.(1159-1161)gcA>gcG	p.A387A	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	387	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GGAGATAGGCTGCCTTGTCAG	0.443000													7	83					0	0	5.18039e-06	0	0
UPF1	5976	broad.mit.edu	37	19	18960966	18960966	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr19:18960966G>T	ENST00000262803.5	+	4	816	c.544G>T	c.(544-546)Gag>Tag	p.E182*	UPF1_ENST00000599848.1_Nonsense_Mutation_p.E182*|UPF1_ENST00000600310.1_3'UTR	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	182	Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						GACAGTCCTGGAGTGCTACAA	0.572000													24	38					1.22574e-08	4.43753e-06	3.10358e-05	1	0
HLA-A	3105	broad.mit.edu	37	6	29910693	29910693	+	Missense_Mutation	SNP	A	A	G	rs41559716	by1000genomes	TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr6:29910693A>G	ENST00000396634.1	+	4	574	c.233A>G	c.(232-234)cAg>cGg	p.Q78R	HLA-A_ENST00000376802.2_Missense_Mutation_p.Q78R|HLA-A_ENST00000376806.5_Missense_Mutation_p.Q78R|HLA-A_ENST00000376809.5_Missense_Mutation_p.Q78R			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	78	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.Q78R(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TGGATAGAGCAGGAGGGGCCG	0.657000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			6	13					0	0	5.9392e-07	0	0
PCDH15	65217	broad.mit.edu	37	10	55996590	55996590	+	Silent	SNP	G	G	A			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr10:55996590G>A	ENST00000373965.2	-	9	1372	c.978C>T	c.(976-978)atC>atT	p.I326I	PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000414778.1_Silent_p.I331I|PCDH15_ENST00000395445.1_Silent_p.I326I|PCDH15_ENST00000373955.1_Silent_p.I326I|PCDH15_ENST00000395433.1_Silent_p.I304I|PCDH15_ENST00000395446.1_Silent_p.I326I|PCDH15_ENST00000395430.1_Silent_p.I326I|PCDH15_ENST00000320301.6_Silent_p.I326I|PCDH15_ENST00000361849.3_Silent_p.I326I|PCDH15_ENST00000395442.1_Silent_p.I326I|PCDH15_ENST00000395432.2_Silent_p.I289I|PCDH15_ENST00000437009.1_Silent_p.I326I|PCDH15_ENST00000373957.3_Silent_p.I304I|PCDH15_ENST00000395440.1_Silent_p.I326I|PCDH15_ENST00000395438.1_Silent_p.I326I	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	326	Cadherin 3.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				AACCAACAAGGATGGAATAGA	0.363000										HNSCC(58;0.16)			27	59					0	0	1.7367e-05	0	0
MYOM1	8736	broad.mit.edu	37	18	3188908	3188908	+	Silent	SNP	T	T	C			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr18:3188908T>C	ENST00000400569.3	-	4	942	c.609A>G	c.(607-609)acA>acG	p.T203T	MYOM1_ENST00000356443.4_Silent_p.T203T|MYOM1_ENST00000261606.7_Silent_p.T203T			P52179	MYOM1_HUMAN	myomesin 1	203	6 X 6 AA tandem repeats.					striated muscle myosin thick filament	structural constituent of muscle	p.T203T(1)		NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GCTTGGATGCTGTGGACTGCT	0.532000													5	93					0	0	5.18039e-06	0	0
RYR2	6262	broad.mit.edu	37	1	237732504	237732504	+	Silent	SNP	C	C	T			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr1:237732504C>T	ENST00000366574.2	+	29	3800	c.3483C>T	c.(3481-3483)gtC>gtT	p.V1161V	RYR2_ENST00000360064.6_Silent_p.V1159V|RYR2_ENST00000542537.1_Silent_p.V1145V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1161	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAGGCGATGTCGTGGGGTGTA	0.502000													13	32					0	0	5.50884e-06	0	0
PSG3	5671	broad.mit.edu	37	19	43243060	43243060	+	Silent	SNP	G	G	A			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr19:43243060G>A	ENST00000327495.5	-	2	430	c.246C>T	c.(244-246)taC>taT	p.Y82Y	PSG3_ENST00000490592.1_5'UTR|PSG3_ENST00000595140.1_Silent_p.Y82Y	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	82	Ig-like V-type.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				CATCTACTACGTATGATGTAA	0.443000													124	203					0	0	2.47226e-05	0	0
CCNE2	9134	broad.mit.edu	37	8	95906253	95906253	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr8:95906253G>T	ENST00000520509.1	-	3	361	c.109C>A	c.(109-111)Cag>Aag	p.Q37K	CCNE2_ENST00000308108.4_Missense_Mutation_p.Q37K|CCNE2_ENST00000396133.3_Missense_Mutation_p.Q37K			O96020	CCNE2_HUMAN	cyclin E2	37					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding			cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|prostate(1)	11	Breast(36;8.75e-07)					TAAATCACCTGGGTAGTTTTC	0.468000													15	841					3.52763e-06	0.00124062	3.52763e-06	1	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													7	74					0	0	5.18039e-06	0	0
HOMER1	9456	broad.mit.edu	37	5	78671906	78671906	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr5:78671906C>T	ENST00000334082.6	-	9	2433	c.991G>A	c.(991-993)Gaa>Aaa	p.E331K	HOMER1_ENST00000282260.6_Missense_Mutation_p.E201K|HOMER1_ENST00000535690.1_Missense_Mutation_p.E157K|HOMER1_ENST00000508576.1_3'UTR	NM_004272.3	NP_004263.1	Q86YM7	HOME1_HUMAN	homer homolog 1 (Drosophila)	331					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane				endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|skin(1)	14		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		TCCAGAATTTCTAAGAGTGTC	0.393000													28	55					0	0	1.32003e-05	0	0
PRDM16	63976	broad.mit.edu	37	1	3328709	3328709	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr1:3328709G>A	ENST00000378398.3	+	10	2033	c.1951G>A	c.(1951-1953)Ggg>Agg	p.G651R	PRDM16_ENST00000378391.2_Missense_Mutation_p.G650R|PRDM16_ENST00000442529.2_Missense_Mutation_p.G650R|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000441472.2_Missense_Mutation_p.G650R|PRDM16_ENST00000270722.5_Missense_Mutation_p.G650R|PRDM16_ENST00000514189.1_Missense_Mutation_p.G651R|PRDM16_ENST00000511072.1_Missense_Mutation_p.G651R			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	650					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GCCCAAGTTTGGGGGCGGCTT	0.687000			T	EVI1	"""MDS, AML"""								34	5					0	0	1.8613e-05	0	0
ZNF35	7584	broad.mit.edu	37	3	44692709	44692709	+	Silent	SNP	G	G	A			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr3:44692709G>A	ENST00000396056.2	+	2	385	c.150G>A	c.(148-150)caG>caA	p.Q50Q	ZNF35_ENST00000399560.2_Silent_p.Q50Q|ZNF35_ENST00000296092.3_Silent_p.Q50Q|ZNF35_ENST00000542250.1_5'UTR|ZNF35_ENST00000453164.1_Silent_p.Q50Q|RP11-944L7.4_ENST00000457331.1_RNA	NM_003420.3	NP_003411.3	P13682	ZNF35_HUMAN	zinc finger protein 35	50	Globular domain.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	12		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		CCCCAGTGCAGGGTCTTCAGA	0.502000													21	34					0	0	3.83957e-06	0	0
ADAM30	11085	broad.mit.edu	37	1	120436620	120436620	+	Silent	SNP	G	G	T			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr1:120436620G>T	ENST00000369400.1	-	1	2498	c.2340C>A	c.(2338-2340)ccC>ccA	p.P780P		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	780					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		TCTTTGCTTTGGGTCGTTTAC	0.368000													49	2240					7.41877e-09	2.7672e-06	2.27731e-05	1	0
LARS	51520	broad.mit.edu	37	5	145533506	145533506	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr5:145533506G>A	ENST00000394434.2	-	11	1269	c.1103C>T	c.(1102-1104)tCa>tTa	p.S368L	LARS_ENST00000545646.1_Missense_Mutation_p.S322L|LARS_ENST00000274562.9_Missense_Mutation_p.S341L|LARS_ENST00000510191.1_Missense_Mutation_p.S314L	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	368	Editing domain.				leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CACCTTGTATGATGTTAAAGG	0.294000													28	48					0	0	1.48458e-05	0	0
HLA-DRB6	3128	broad.mit.edu	37	6	32522401	32522401	+	RNA	SNP	G	G	A	rs36183131	by1000genomes	TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr6:32522401G>A	ENST00000411500.1	-	0	740					NR_001298.1																						GAAACCTGACGCTCAGGGATT	0.483000													4	17					0	0	5.18039e-06	0	0
PTPN1	5770	broad.mit.edu	37	20	49195776	49195776	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr20:49195776G>T	ENST00000371621.3	+	7	948	c.774G>T	c.(772-774)atG>atT	p.M258I	PTPN1_ENST00000541713.1_Missense_Mutation_p.M185I	NM_001278618.1|NM_002827.2	NP_001265547.1|NP_002818.1	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type 1	258	Tyrosine-protein phosphatase.				blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(2)	16		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	AGTTTCGGATGGGGCTGATCC	0.502000													57	195					3.89483e-19	1.49817e-16	2.47226e-05	1	0
PASK	23178	broad.mit.edu	37	2	242066278	242066278	+	Silent	SNP	C	C	T			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr2:242066278C>T	ENST00000403638.3	-	10	2143	c.2052G>A	c.(2050-2052)ccG>ccA	p.P684P	PASK_ENST00000539818.1_Silent_p.P468P|PASK_ENST00000544142.1_Silent_p.P498P|PASK_ENST00000405260.1_Silent_p.P684P|PASK_ENST00000234040.4_Silent_p.P684P|PASK_ENST00000358649.4_Silent_p.P684P	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	684			P -> R (in dbSNP:rs56372985).		regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GGCACTCTGTCGGAACGAGTT	0.617000													28	59					0	0	2.90539e-05	0	0
BCL9L	283149	broad.mit.edu	37	11	118779312	118779312	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr11:118779312G>A	ENST00000334801.3	-	2	1043	c.79C>T	c.(79-81)Cgc>Tgc	p.R27C	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	27					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		CAATGACCGCGGGGGGACAGC	0.592000													7	15					0	0	1.12685e-05	0	0
PHF3	23469	broad.mit.edu	37	6	64394879	64394879	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr6:64394879C>T	ENST00000262043.3	+	4	1596	c.1256C>T	c.(1255-1257)tCa>tTa	p.S419L	PHF3_ENST00000509330.1_Missense_Mutation_p.S419L|PHF3_ENST00000393387.1_Missense_Mutation_p.S419L			Q92576	PHF3_HUMAN	PHD finger protein 3	419					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TTTAATAAATCAAACTTAGAG	0.363000													33	61					0	0	1.48458e-05	0	0
LMBRD2	92255	broad.mit.edu	37	5	36123065	36123066	+	Splice_Site	INS	-	-	A	rs72438158		TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr5:36123065_36123066insA	ENST00000296603.4	-	8	1285		c.e8-2			NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2							integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGTAGGGCACtaaaaaaaaaaa	0.252													7	43	---	---	---	---					
ZAN	7455	broad.mit.edu	37	7	100369721	100369721	+	RNA	DEL	T	T	-			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr7:100369721delT	ENST00000542585.1	+	0	5573				ZAN_ENST00000443370.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546213.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ctctaaattcttttttttttt	0.532													2	4	---	---	---	---					
NDUFS7	374291	broad.mit.edu	37	19	1388895	1388896	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-D3-A2J6-06A-11D-A19A-08	TCGA-D3-A2J6-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1877f1-669a-4916-ab45-365dbc10f580	9dda350d-cbaa-40f9-9e44-733f8dcdea17	g.chr19:1388895_1388896delTG	ENST00000313408.7	+	4	209_210	c.186_187delTG	c.(184-189)tatgfs	p.YV62fs	NDUFS7_ENST00000539480.1_Frame_Shift_Del_p.YV62fs|NDUFS7_ENST00000233627.9_Frame_Shift_Del_p.YV62fs|NDUFS7_ENST00000414651.2_Frame_Shift_Del_p.YV92fs|NDUFS7_ENST00000546283.1_Frame_Shift_Del_p.YV62fs|NDUFS7_ENST00000540530.1_3'UTR			O75251	NDUS7_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)	62					mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			ovary(1)	1		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)|Breast(49;0.00186)|Lung NSC(49;0.00292)|all_lung(49;0.00419)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	NADH(DB00157)	GGGGCGAGTATGTGGTGGCCAA	0.663													2	4	---	---	---	---