Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-1407O15.2	0	broad.mit.edu	37	17	36357265	36357265	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr17:36357265C>T	ENST00000312412.4	-	9	987	c.988G>A	c.(988-990)Gca>Aca	p.A330T	TBC1D3_ENST00000537432.1_5'UTR|RP11-1407O15.2_ENST00000544906.1_Missense_Mutation_p.A175T																kidney(1)|lung(3)	4						ATAAGCAATGCAGTCTCCCTA	0.378000													6	24					0	0	8.12818e-05	0	0
ZNF99	7652	broad.mit.edu	37	19	22940600	22940600	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr19:22940600G>T	ENST00000397104.3	-	5	1837	c.1838C>A	c.(1837-1839)cCc>cAc	p.P613H	ZNF99_ENST00000596209.1_Missense_Mutation_p.P704H					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ACATTTGTAGGGTTTCTTTCC	0.373000													4	23					1.024e-07	1.10892e-06	0.000602214	1	0
MUC16	94025	broad.mit.edu	37	19	9080450	9080450	+	Splice_Site	SNP	C	C	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr19:9080450C>T	ENST00000397910.4	-	2	9784		c.e2+1			NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated						cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTATATTTACCTGCTGGACT	0.448000													8	47					0	0	0.000442599	0	0
GPR20	2843	broad.mit.edu	37	8	142367126	142367126	+	Missense_Mutation	SNP	C	C	T	rs150478338		TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr8:142367126C>T	ENST00000377741.3	-	2	988	c.898G>A	c.(898-900)Gtc>Atc	p.V300I		NM_005293.2	NP_005284.2	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	300						integral to plasma membrane	G-protein coupled receptor activity	p.V300I(1)		NS(1)|endometrium(3)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	15	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CCACTGGTGACGAAGCAGTAG	0.647000													7	50					0	0	0.000157383	0	0
PLOD1	5351	broad.mit.edu	37	1	12025608	12025608	+	Silent	SNP	C	C	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr1:12025608C>T	ENST00000196061.4	+	14	1569	c.1542C>T	c.(1540-1542)acC>acT	p.T514T	PLOD1_ENST00000376369.3_Silent_p.T561T	NM_000302.3	NP_000293.2	Q02809	PLOD1_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	514					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	ACCGCACCACCCACCTGCACA	0.632000													14	67					0	0	0.000308642	0	0
ASH1L	55870	broad.mit.edu	37	1	155450458	155450458	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr1:155450458C>G	ENST00000368346.3	-	3	2842	c.2203G>C	c.(2203-2205)Gaa>Caa	p.E735Q	ASH1L_ENST00000392403.3_Missense_Mutation_p.E735Q			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	735					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CTTTCTAATTCTAGCCCTTTT	0.393000													7	36					0	0	8.12818e-05	0	0
ANKMY2	57037	broad.mit.edu	37	7	16650312	16650312	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr7:16650312A>C	ENST00000306999.2	-	6	851	c.608T>G	c.(607-609)tTg>tGg	p.L203W		NM_020319.2	NP_064715.1	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	203						cilium	zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	23	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		CTCACAAATCAAATCCATCAC	0.373000													11	46					0	0	0.000151284	0	0
TOM1L1	10040	broad.mit.edu	37	17	52981124	52981124	+	Silent	SNP	C	C	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr17:52981124C>T	ENST00000575882.1	+	2	467	c.114C>T	c.(112-114)atC>atT	p.I38I	TOM1L1_ENST00000572405.1_Silent_p.I3I|TOM1L1_ENST00000540336.1_5'UTR|TOM1L1_ENST00000536554.1_Intron|TOM1L1_ENST00000570371.1_Silent_p.I38I|TOM1L1_ENST00000348161.4_Intron|TOM1L1_ENST00000572158.1_Silent_p.I38I|TOM1L1_ENST00000445275.2_Silent_p.I38I|TOM1L1_ENST00000575333.1_Silent_p.I38I	NM_005486.2	NP_005477.2	O75674	TM1L1_HUMAN	target of myb1 (chicken)-like 1	38	VHS.				intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	15						TCATGCACATCTGTGACATAA	0.428000													9	61					0	0	0.000442599	0	0
ASPM	259266	broad.mit.edu	37	1	197091378	197091378	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr1:197091378G>C	ENST00000367409.4	-	15	3908	c.3652C>G	c.(3652-3654)Cac>Gac	p.H1218D	ASPM_ENST00000367408.1_Missense_Mutation_p.H468D|ASPM_ENST00000294732.7_Missense_Mutation_p.H1218D	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	1218	CH 2.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						CTAACCAAGTGAAAATTTTTC	0.348000													3	25					0	0	6.4e-05	0	0
MAPKAPK2	9261	broad.mit.edu	37	1	206905225	206905225	+	Silent	SNP	G	G	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr1:206905225G>T	ENST00000367103.3	+	9	1213	c.1020G>T	c.(1018-1020)cgG>cgT	p.R340R	MAPKAPK2_ENST00000294981.4_Silent_p.R340R|MAPKAPK2_ENST00000479009.1_3'UTR	NM_004759.4|NM_032960.3	NP_004750.1|NP_116584.2	P49137	MAPK2_HUMAN	mitogen-activated protein kinase-activated protein kinase 2	340					activation of MAPK activity|hormone biosynthetic process|innate immune response|leukotriene biosynthetic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|prostanoid metabolic process|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	19	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			ACACCAGCCGGGTCCTGAAGG	0.622000													12	53					2.27111e-07	2.40089e-06	0.00010058	1	0
ZNF99	7652	broad.mit.edu	37	19	22941562	22941562	+	Silent	SNP	G	G	A			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr19:22941562G>A	ENST00000397104.3	-	5	875	c.876C>T	c.(874-876)gcC>gcT	p.A292A	ZNF99_ENST00000596209.1_Silent_p.A383A					zinc finger protein 99									p.A292A(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GTTTTCTAAGGGCTGACAAAT	0.368000													6	51					0	0	8.12818e-05	0	0
ID2	3398	broad.mit.edu	37	2	8822514	8822514	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr2:8822514G>C	ENST00000234091.4	+	3	1079	c.219G>C	c.(217-219)ttG>ttC	p.L73F	ID2_ENST00000331129.3_Missense_Mutation_p.L73F|ID2_ENST00000396290.1_Missense_Mutation_p.L73F			Q02363	ID2_HUMAN	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	73	Helix-loop-helix motif.				cellular senescence|embryonic digestive tract morphogenesis|endodermal digestive tract morphogenesis|epithelial cell differentiation involved in mammary gland alveolus development|mammary gland epithelial cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of neuron differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|neuron fate commitment|positive regulation of blood pressure|positive regulation of cell cycle arrest|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent	protein complex	protein binding			breast(1)|large_intestine(1)|lung(1)|prostate(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					ACTACATCTTGGACCTGCAGA	0.587000													22	138					0	0	0.000229342	0	0
IFIT2	3433	broad.mit.edu	37	10	91066107	91066107	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr10:91066107A>G	ENST00000371826.3	+	2	563	c.394A>G	c.(394-396)Aga>Gga	p.R132G	LIPA_ENST00000371837.1_Intron|LIPA_ENST00000487618.1_Intron	NM_001547.4	NP_001538.4	P09913	IFIT2_HUMAN	interferon-induced protein with tetratricopeptide repeats 2	132					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|skin(1)	12		Colorectal(252;0.0161)				CAGTCCCTATAGAATTGAGAG	0.458000													8	33					0	0	0.000442599	0	0
GLI3	2737	broad.mit.edu	37	7	42005321	42005321	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr7:42005321G>T	ENST00000395925.3	-	15	3434	c.3350C>A	c.(3349-3351)cCg>cAg	p.P1117Q	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	1117					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P1117Q(1)		NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						GCTGTCGTCCGGGAGGGCGCT	0.637000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				4	74					0.000602214	0.00581268	0.000602214	1	0
PLEKHA5	54477	broad.mit.edu	37	12	19522626	19522626	+	Splice_Site	SNP	G	G	C			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr12:19522626G>C	ENST00000538714.1	+	27	3434		c.e27-1		PLEKHA5_ENST00000359180.3_Splice_Site|PLEKHA5_ENST00000424268.1_Splice_Site|PLEKHA5_ENST00000429027.2_Splice_Site|PLEKHA5_ENST00000299275.6_Splice_Site|PLEKHA5_ENST00000317589.4_Splice_Site|PLEKHA5_ENST00000539256.1_Splice_Site|PLEKHA5_ENST00000355397.3_Splice_Site|PLEKHA5_ENST00000543806.1_Splice_Site	NM_001143821.2	NP_001137293.2	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A member 5								1-phosphatidylinositol binding|protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					GTGTGTTTTAGTGAAAAGTCT	0.408000													7	19					0	0	8.12818e-05	0	0
BRD3	8019	broad.mit.edu	37	9	136918456	136918456	+	Silent	SNP	C	C	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr9:136918456C>T	ENST00000303407.7	-	2	329	c.144G>A	c.(142-144)aaG>aaA	p.K48K	BRD3_ENST00000357885.2_Silent_p.K48K|BRD3_ENST00000371834.2_Silent_p.K48K	NM_007371.3	NP_031397.1	Q15059	BRD3_HUMAN	bromodomain containing 3	48						nucleus	protein binding		BRD3/C15orf55(3)	kidney(1)|skin(1)|stomach(4)	6				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		TCCAGAGCGTCTTCACCACCA	0.637000			T	C15orf55	lethal midline carcinoma of young people								8	53					0	0	0.000274275	0	0
SEC22B	9554	broad.mit.edu	37	1	145116027	145116027	+	RNA	SNP	T	T	C	rs7550440		TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr1:145116027T>C	ENST00000453618.1	+	0	1113							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										AAAAGAGATGTCCTGAAAATG	0.423000													4	12					0	0	0.00024832	0	0
CYBA	1535	broad.mit.edu	37	16	88713222	88713222	+	Silent	SNP	C	C	A			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr16:88713222C>A	ENST00000569359.1	-	4	244	c.228G>T	c.(226-228)gtG>gtT	p.V76V	CYBA_ENST00000567174.1_Silent_p.V76V|CYBA_ENST00000261623.3_Silent_p.V76V			P13498	CY24A_HUMAN	cytochrome b-245, alpha polypeptide	76					cytochrome complex assembly|electron transport chain|hydrogen peroxide biosynthetic process|inflammatory response|innate immune response|respiratory burst|smooth muscle hypertrophy|superoxide anion generation|transport	NADPH oxidase complex|stored secretory granule	electron carrier activity|heme binding|protein heterodimerization activity|SH3 domain binding			endometrium(1)|liver(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0478)		ACAGCTTCACCACGGCGGTCA	0.652000													10	26					6.40141e-05	0.000645961	0.000978159	1	0
KRTAP4-2	85291	broad.mit.edu	37	17	39334125	39334125	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr17:39334125G>C	ENST00000377726.2	-	1	335	c.292C>G	c.(292-294)Ccc>Gcc	p.P98A		NM_033062.3	NP_149051.1	Q9BYR5	KRA42_HUMAN	keratin associated protein 4-2	98	20 X 5 AA repeats OF C-C-[GRQVS]-[SPT]- [VSTQ].					keratin filament				kidney(2)|lung(4)|upper_aerodigestive_tract(1)	7		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			CAGCAGGTGGGCTGGCAGTAC	0.667000													6	64					0	0	3.59834e-05	0	0
ILF3	3609	broad.mit.edu	37	19	10790580	10790580	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr19:10790580T>A	ENST00000449870.1	+	8	1153	c.836T>A	c.(835-837)cTg>cAg	p.L279Q	ILF3_ENST00000407004.3_Missense_Mutation_p.L279Q|ILF3_ENST00000590261.1_Missense_Mutation_p.L279Q|ILF3_ENST00000250241.8_Missense_Mutation_p.L279Q|ILF3_ENST00000589998.1_Missense_Mutation_p.L279Q|ILF3_ENST00000420083.1_Missense_Mutation_p.L279Q|ILF3_ENST00000588657.1_Missense_Mutation_p.L279Q|ILF3_ENST00000592763.1_Missense_Mutation_p.L279Q|ILF3_ENST00000318511.3_Missense_Mutation_p.L279Q	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	279	DZF.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			CTGGAGTGCCTGGCGTCGGGC	0.632000													5	23					0	0	3.59834e-05	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203711	140203711	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr5:140203711A>G	ENST00000378126.3	+	1	2351	c.2351A>G	c.(2350-2352)aAc>aGc	p.N784S	PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529619.1_Splice_Site_p.N784_splice|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Splice_Site_p.N784_splice	NM_031501.1	NP_113689.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTACAGACAACGTGAGTTTT	0.428000													7	85					0	0	8.12818e-05	0	0
HAO2	51179	broad.mit.edu	37	1	119925606	119925606	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr1:119925606A>T	ENST00000361035.4	+	4	522	c.239A>T	c.(238-240)gAg>gTg	p.E80V	HAO2_ENST00000325945.3_Missense_Mutation_p.E67V	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	67	FMN hydroxy acid dehydrogenase.			F -> Y (in Ref. 2; AAF14000).	fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		ATCCAAGGGGAGGAGATCAGT	0.547000													5	18					0	0	0.000602214	0	0
GABRD	2563	broad.mit.edu	37	1	1961584	1961584	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr1:1961584C>T	ENST00000378585.4	+	9	1305	c.1222C>T	c.(1222-1224)Cgc>Tgc	p.R408C		NM_000815.4	NP_000806.2	O14764	GBRD_HUMAN	gamma-aminobutyric acid (GABA) A receptor, delta	408						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(2)|endometrium(3)|kidney(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;2.7e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.17e-24)|GBM - Glioblastoma multiforme(42;9.56e-08)|Colorectal(212;4.12e-05)|COAD - Colon adenocarcinoma(227;0.000194)|Kidney(185;0.00231)|BRCA - Breast invasive adenocarcinoma(365;0.00441)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		GGGGGCAGCCCGCTCAGGAGG	0.701000													6	45					0	0	3.59834e-05	0	0
FRG1B	284802	broad.mit.edu	37	20	29628233	29628233	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr20:29628233A>G	ENST00000278882.3	+	6	615	c.235A>G	c.(235-237)Atg>Gtg	p.M79V	FRG1B_ENST00000439954.2_Missense_Mutation_p.M84V|FRG1B_ENST00000358464.4_Missense_Mutation_p.M79V																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TTAGGGGAAAATGGCTTTGTT	0.363000													4	42					0	0	3.59834e-05	0	0
PXDN	7837	broad.mit.edu	37	2	1652989	1652989	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr2:1652989G>A	ENST00000252804.4	-	17	2613	c.2563C>T	c.(2563-2565)Ccc>Tcc	p.P855S		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	855					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		AAGCAGGGGGGGTCGTTGCTG	0.677000													4	102					0	0	0.00024832	0	0
ID2	3398	broad.mit.edu	37	2	8822644	8822644	+	Splice_Site	SNP	G	G	A			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr2:8822644G>A	ENST00000234091.4	+	3	1208		c.e3+1		ID2_ENST00000331129.3_Splice_Site|ID2_ENST00000396290.1_Splice_Site			Q02363	ID2_HUMAN	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein						cellular senescence|embryonic digestive tract morphogenesis|endodermal digestive tract morphogenesis|epithelial cell differentiation involved in mammary gland alveolus development|mammary gland epithelial cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of neuron differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|neuron fate commitment|positive regulation of blood pressure|positive regulation of cell cycle arrest|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent	protein complex	protein binding			breast(1)|large_intestine(1)|lung(1)|prostate(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTCCTTGCAGGTAAGACCTGC	0.632000													20	83					0	0	0.000132079	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332492	22332492	+	RNA	SNP	A	A	C			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr15:22332492A>C	ENST00000558896.1	+	0	299																											TATTTCTCTTATTACTATTTT	0.383000													5	189					0	0	0.000602214	0	0
FAM151A	338094	broad.mit.edu	37	1	55076151	55076151	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr1:55076151G>C	ENST00000302250.2	-	7	1178	c.1018C>G	c.(1018-1020)Ctg>Gtg	p.L340V	FAM151A_ENST00000371304.2_Intron|ACOT11_ENST00000371316.3_Intron	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	340						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						TCCACATTCAGACCGTCATCC	0.592000													4	48					0	0	3.59834e-05	0	0
NBEA	26960	broad.mit.edu	37	13	35619181	35619181	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr13:35619181C>G	ENST00000540320.1	+	3	1158	c.624C>G	c.(622-624)atC>atG	p.I208M	NBEA_ENST00000400445.3_Missense_Mutation_p.I208M|NBEA_ENST00000379939.2_Missense_Mutation_p.I208M|NBEA_ENST00000310336.4_Missense_Mutation_p.I208M			Q8NFP9	NBEA_HUMAN	neurobeachin	208						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		AAAGTGGAATCTGGGTAAGCT	0.398000													4	5					0	0	0.000602214	0	0
LAMB2	3913	broad.mit.edu	37	3	49165975	49165975	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr3:49165975G>A	ENST00000418109.1	-	16	2098	c.1934C>T	c.(1933-1935)cCa>cTa	p.P645L	LAMB2_ENST00000305544.4_Missense_Mutation_p.P645L	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	645	Laminin IV type B.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CACAGGCCCTGGACGCTGCAC	0.597000													9	35					0	0	0.000442599	0	0
MEGF10	84466	broad.mit.edu	37	5	126738307	126738307	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr5:126738307C>A	ENST00000274473.6	+	9	1117	c.850C>A	c.(850-852)Cat>Aat	p.H284N	MEGF10_ENST00000503335.2_Missense_Mutation_p.H284N|MEGF10_ENST00000418761.2_Missense_Mutation_p.H284N|MEGF10_ENST00000508365.1_Missense_Mutation_p.H284N	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	284	EGF-like 5.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		ATGCCAGTGCCATAATGGAGG	0.507000													23	74					5.45024e-15	6.20489e-14	0.00047179	1	0
DNAH5	1767	broad.mit.edu	37	5	13737373	13737373	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr5:13737373C>T	ENST00000265104.4	-	66	11547	c.11443G>A	c.(11443-11445)Gaa>Aaa	p.E3815K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3815					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.E3815K(1)		NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGTCTGTATTCCTCCCGGGCT	0.428000									Kartagener syndrome				15	106					0	0	0.000422831	0	0
CTNNA3	29119	broad.mit.edu	37	10	68940148	68940148	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr10:68940148C>T	ENST00000433211.1	-	7	1148	c.974G>A	c.(973-975)cGa>cAa	p.R325Q	CTNNA3_ENST00000373744.4_Missense_Mutation_p.R325Q|CTNNA3_ENST00000545309.1_Missense_Mutation_p.R325Q|CTNNA3_ENST00000494580.1_5'UTR	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	325					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						AATCCGCTCTCGGTGTAAGTC	0.512000													10	30					0	0	0.000673444	0	0
EGF	1950	broad.mit.edu	37	4	110882136	110882136	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr4:110882136C>T	ENST00000265171.5	+	7	1625	c.1180C>T	c.(1180-1182)Cga>Tga	p.R394*	EGF_ENST00000509793.1_Nonsense_Mutation_p.R352*|EGF_ENST00000503392.1_Nonsense_Mutation_p.R394*	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	394	EGF-like 2; calcium-binding (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TGATGGGAAACGATGTCATCG	0.398000													9	34					0	0	0.000274275	0	0
CT47B1	643311	broad.mit.edu	37	X	120007818	120007818	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chrX:120007818C>T	ENST00000371311.3	-	2	1086	c.832G>A	c.(832-834)Gag>Aag	p.E278K		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	278										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						TTCTCTTCCTCGCCTGCAGCA	0.468000													89	337					0	0	0.000781405	0	0
MSANTD4	84437	broad.mit.edu	37	11	105880673	105880673	+	Silent	SNP	T	T	C			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr11:105880673T>C	ENST00000301919.4	-	3	2042	c.627A>G	c.(625-627)aaA>aaG	p.K209K		NM_032424.1	NP_115800.1	Q8NCY6	K1826_HUMAN	Myb/SANT-like DNA-binding domain containing 4 with coiled-coils	209						nucleus											CTAGTTTCTGTTTCTCAATAT	0.438000													13	44					0	0	0.000219431	0	0
GFPT2	9945	broad.mit.edu	37	5	179731790	179731790	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr5:179731790C>A	ENST00000253778.8	-	17	1993	c.1824G>T	c.(1822-1824)caG>caT	p.Q608H		NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	608	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	CCGTGACTTGCTGCAGGGCGT	0.592000													12	186					0.00010058	0.000992388	0.00010058	1	0
LOC101927079	101927079	broad.mit.edu	37	15	22332432	22332432	+	RNA	SNP	C	C	T			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr15:22332432C>T	ENST00000558896.1	+	0	239																											AAGATTCTAACGTGACAGAAC	0.343000													7	105					0	0	8.12818e-05	0	0
NSD1	64324	broad.mit.edu	37	5	176721888	176721888	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr5:176721888G>A	ENST00000439151.2	+	23	7564	c.7519G>A	c.(7519-7521)Ggc>Agc	p.G2507S	NSD1_ENST00000354179.4_Missense_Mutation_p.G2238S|NSD1_ENST00000347982.4_Missense_Mutation_p.G2238S|NSD1_ENST00000361032.4_Missense_Mutation_p.G2404S	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2507					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TGTTGAGAAAGGCTGTGTGTC	0.537000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			16	108					0	0	0.000958276	0	0
LGI4	163175	broad.mit.edu	37	19	35616221	35616221	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr19:35616221G>A	ENST00000310123.3	-	9	2009	c.1490C>T	c.(1489-1491)cCg>cTg	p.P497L	LGI4_ENST00000392225.3_3'UTR|LGI4_ENST00000493050.1_5'UTR	NM_139284.2	NP_644813.1	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	497						extracellular region				endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			CACCAGGGCCGGAGGCCCCAG	0.642000													4	30					0	0	0.000602214	0	0
DNAH5	1767	broad.mit.edu	37	5	13737425	13737425	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr5:13737425C>A	ENST00000265104.4	-	66	11495	c.11391G>T	c.(11389-11391)caG>caT	p.Q3797H		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3797	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTTCTAGCTTCTGTGTCACCT	0.463000									Kartagener syndrome				15	108					2.32078e-09	2.57607e-08	0.000308642	1	0
CXorf67	340602	broad.mit.edu	37	X	51150037	51150037	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chrX:51150037G>A	ENST00000342995.2	+	1	271	c.169G>A	c.(169-171)Ggc>Agc	p.G57S						chromosome X open reading frame 67											breast(1)|endometrium(4)|large_intestine(1)|lung(11)|ovary(3)|prostate(1)	21						TCCCTCGGGCGGCGCCGCCCT	0.652000													3	10					0	0	0.00024832	0	0
CLOCK	9575	broad.mit.edu	37	4	56336954	56336954	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chr4:56336954delA	ENST00000309964.4	-	7	618	c.368delT	c.(367-369)tafs	p.L123fs	CLOCK_ENST00000381322.1_Frame_Shift_Del_p.L123fs|CLOCK_ENST00000513440.1_Frame_Shift_Del_p.L123fs	NM_004898.3	NP_004889.1	O15516	CLOCK_HUMAN	clock circadian regulator	123	PAS 1.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity	p.L123fs*1(2)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(8)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			CATGATTGCTAAAAAAAAACC	0.289													8	87	---	---	---	---					
NUDT11	55190	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-	rs78182391		TCGA-D3-A3CF-06A-11D-A196-08	TCGA-D3-A3CF-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4de17e47-b1e8-458e-a8f1-be1e5d095f17	5f9d120e-e36f-45c2-8cbf-d11e68d80b2a	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	ENST00000375992.3	-	0	139_152					NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.?(5)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.692										HNSCC(48;0.14)			4	9	---	---	---	---