Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MYCBP2	23077	broad.mit.edu	37	13	77718653	77718653	+	Silent	SNP	A	A	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr13:77718653A>G	ENST00000407578.2	-	49	7496	c.7230T>C	c.(7228-7230)acT>acC	p.T2410T	MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000357337.6_Silent_p.T2372T|MYCBP2_ENST00000544440.2_Silent_p.T2372T	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	2372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTGCACAATAAGTCCCATCAT	0.378000													6	146					0	0	0.307466	0	0
FMNL2	114793	broad.mit.edu	37	2	153475450	153475450	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:153475450G>A	ENST00000288670.9	+	14	1772	c.1405G>A	c.(1405-1407)Gaa>Aaa	p.E469K		NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	469	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						GTCTACCCTGGAAAAAAAGAT	0.378000													23	25					0	0	0.639603	0	0
DSC1	1823	broad.mit.edu	37	18	28728554	28728554	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:28728554G>A	ENST00000257197.3	-	6	940	c.679C>T	c.(679-681)Cct>Tct	p.P227S	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257198.5_Missense_Mutation_p.P227S	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	227	Cadherin 1.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ATGATCAAAGGGAGTGGATAT	0.378000													24	48					0	0	0.693898	0	0
TREML2	79865	broad.mit.edu	37	6	41166097	41166097	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:41166097G>A	ENST00000483722.1	-	2	311	c.126C>T	c.(124-126)tcC>tcT	p.S42S		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	42	Ig-like V-type.				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGCCCTTATAGGAGCACTGCA	0.517000													47	81					0	0	0.870114	0	0
CD63	967	broad.mit.edu	37	12	56120749	56120749	+	Splice_Site	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:56120749C>T	ENST00000549117.1	-	4	692		c.e4-1		CD63_ENST00000552692.1_Splice_Site|CD63_ENST00000552067.1_Splice_Site|CD63_ENST00000552754.1_Splice_Site|CD63_ENST00000548160.1_5'UTR|CD63_ENST00000420846.3_Splice_Site|CD63_ENST00000257857.4_Splice_Site|CD63_ENST00000550776.1_Splice_Site|CD63_ENST00000546939.1_Splice_Site|CD63_ENST00000548898.1_Splice_Site	NM_001257389.1	NP_001244318.1	P08962	CD63_HUMAN	CD63 molecule						platelet activation|platelet degranulation	integral to plasma membrane|late endosome membrane|lysosomal membrane|platelet dense granule membrane				kidney(1)|large_intestine(3)|lung(2)|ovary(1)	7						AGATGGCAAACTGCAGGAGCA	0.512000													66	56					0	0	0.870114	0	0
ITGA6	3655	broad.mit.edu	37	2	173349578	173349578	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:173349578C>T	ENST00000375221.2	+	13	1938	c.1735C>T	c.(1735-1737)Cga>Tga	p.R579*	AC093818.1_ENST00000442417.1_RNA|ITGA6_ENST00000409532.1_Nonsense_Mutation_p.R421*|ITGA6_ENST00000343713.4_Nonsense_Mutation_p.R535*|ITGA6_ENST00000409080.1_Nonsense_Mutation_p.R540*|ITGA6_ENST00000264106.6_Nonsense_Mutation_p.R579*|ITGA6_ENST00000264107.7_Nonsense_Mutation_p.R540*			P23229	ITA6_HUMAN	integrin, alpha 6	579					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			AGTTCAGTTTCGAAACCAAGG	0.408000													13	63					0	0	0.457914	0	0
MUC16	94025	broad.mit.edu	37	19	9085237	9085237	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:9085237G>A	ENST00000397910.4	-	1	6781	c.6578C>T	c.(6577-6579)tCc>tTc	p.S2193F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2193	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CATTCTAAAGGAAACCAAAGA	0.468000													3	19					0	0	0.150653	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497661	1497661	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:1497661G>A	ENST00000421627.2	+	2	936	c.802G>A	c.(802-804)Gac>Aac	p.D268N		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	347					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GAGCAACAACGACGTCAAGTG	0.667000													24	34					0	0	0.654019	0	0
USP21	27005	broad.mit.edu	37	1	161130686	161130686	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:161130686C>T	ENST00000368002.3	+	3	633	c.256C>T	c.(256-258)Cat>Tat	p.H86Y	USP21_ENST00000289865.8_Missense_Mutation_p.H86Y|USP21_ENST00000368001.1_Missense_Mutation_p.H86Y	NM_001014443.2	NP_001014443.1	Q9UK80	UBP21_HUMAN	ubiquitin specific peptidase 21	86					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|prostate(3)	29	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TCGAGCAGATCATGGGGTTCC	0.637000													26	7					0	0	0.729181	0	0
TMEM209	84928	broad.mit.edu	37	7	129841882	129841882	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:129841882G>A	ENST00000397622.2	-	5	503	c.381C>T	c.(379-381)ccC>ccT	p.P127P	RP11-775D22.3_ENST00000483283.1_RNA|TMEM209_ENST00000336804.8_Silent_p.P126P|TMEM209_ENST00000462753.1_Silent_p.P126P|TMEM209_ENST00000473456.1_Silent_p.P127P	NM_032842.3	NP_116231.2	Q96SK2	TM209_HUMAN	transmembrane protein 209	127						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	12	Melanoma(18;0.0435)					AAGGTGGAGCGGGAGGGATTT	0.463000													22	38					0	0	0.667858	0	0
SEC23B	10483	broad.mit.edu	37	20	18511378	18511378	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:18511378C>T	ENST00000336714.3	+	10	1596	c.1164C>T	c.(1162-1164)ttC>ttT	p.F388F	SEC23B_ENST00000377465.1_Silent_p.F388F|SEC23B_ENST00000377475.3_Silent_p.F388F|SEC23B_ENST00000262544.2_Silent_p.F388F	NM_006363.4|NM_032985.4|NM_032986.3	NP_006354.2|NP_116780.1|NP_116781.1	Q15437	SC23B_HUMAN	Sec23 homolog B (S. cerevisiae)	388					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	32						AGCAGACATTCCAAAGAATCT	0.338000													34	22					0	0	0.827153	0	0
NLRP7	199713	broad.mit.edu	37	19	55451490	55451490	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:55451490C>T	ENST00000588756.1	-	6	1183	c.697G>A	c.(697-699)Gaa>Aaa	p.E233K	NLRP7_ENST00000328092.5_Missense_Mutation_p.E233K|NLRP7_ENST00000592784.1_Missense_Mutation_p.E233K|NLRP7_ENST00000590030.1_Missense_Mutation_p.E233K|NLRP7_ENST00000448121.2_Missense_Mutation_p.E233K|NLRP7_ENST00000340844.2_Missense_Mutation_p.E233K|NLRP7_ENST00000446217.1_Missense_Mutation_p.E261K			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	233	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TCCTGCAATTCAGGCCAGTCT	0.567000													57	41					0	0	0.870114	0	0
PTPRK	5796	broad.mit.edu	37	6	128304508	128304508	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:128304508C>T	ENST00000368227.3	-	24	3683	c.3317G>A	c.(3316-3318)cGa>cAa	p.R1106Q	PTPRK_ENST00000368213.5_Missense_Mutation_p.R1095Q|PTPRK_ENST00000532331.1_Missense_Mutation_p.R1111Q|PTPRK_ENST00000368215.3_Missense_Mutation_p.R1088Q|PTPRK_ENST00000368226.4_Missense_Mutation_p.R1089Q|PTPRK_ENST00000368210.3_Missense_Mutation_p.R1107Q|PTPRK_ENST00000368207.3_Missense_Mutation_p.R1121Q			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1088	Tyrosine-protein phosphatase 1.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		GCAGCCAGTTCGTCCAGCACC	0.383000													13	36					0	0	0.479597	0	0
CCDC28A	25901	broad.mit.edu	37	6	139094904	139094904	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:139094904C>T	ENST00000332797.6	+	1	248	c.93C>T	c.(91-93)ttC>ttT	p.F31F		NM_015439.2	NP_056254.1	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	31										autonomic_ganglia(1)|large_intestine(3)|lung(8)|ovary(1)	13				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		TACGTCACTTCCGTAAACAAA	0.642000													41	86					0	0	0.870114	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													3	24					0	0	0.115264	0	0
RIMS1	22999	broad.mit.edu	37	6	72596752	72596752	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:72596752G>A	ENST00000264839.7	+	1	26	c.26G>A	c.(25-27)gGt>gAt	p.G9D	RIMS1_ENST00000348717.5_Missense_Mutation_p.G9D|RIMS1_ENST00000517960.1_Missense_Mutation_p.G9D|RIMS1_ENST00000522291.1_Missense_Mutation_p.G9D|RIMS1_ENST00000521978.1_Missense_Mutation_p.G9D|RIMS1_ENST00000520567.1_Missense_Mutation_p.G9D|RIMS1_ENST00000491071.2_Missense_Mutation_p.G9D|RIMS1_ENST00000518273.1_Missense_Mutation_p.G9D			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	9					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GGGCCCCGCGGTCCTCGCCCA	0.677000													10	12					0	0	0.411799	0	0
ZNF320	162967	broad.mit.edu	37	19	53384634	53384634	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:53384634C>G	ENST00000595635.1	-	8	1246	c.745G>C	c.(745-747)Gag>Cag	p.E249Q	ZNF320_ENST00000600930.1_Intron|ZNF320_ENST00000391781.2_Missense_Mutation_p.E249Q|ZNF320_ENST00000597909.1_Intron	NM_207333.2	NP_997216.2	A2RRD8	ZN320_HUMAN	zinc finger protein 320	249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(4)|large_intestine(5)|liver(1)|lung(10)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(134;0.0534)		TTGCCACACTCATTACACTTA	0.393000													42	48					0	0	0.870114	0	0
STAP1	26228	broad.mit.edu	37	4	68459042	68459042	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:68459042G>A	ENST00000265404.2	+	8	876	c.794G>A	c.(793-795)aGa>aAa	p.R265K	STAP1_ENST00000396225.1_Missense_Mutation_p.R265K	NM_012108.2	NP_036240.1	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	265	SH2.				cellular membrane fusion|intracellular protein transport	cytoplasm				NS(1)|large_intestine(1)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	12						GGAAATTTAAGACCATTTATA	0.338000													34	17					0	0	0.840704	0	0
XIRP2	129446	broad.mit.edu	37	2	167992518	167992518	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:167992518G>A	ENST00000409195.1	+	3	597	c.508G>A	c.(508-510)Gaa>Aaa	p.E170K	XIRP2_ENST00000409756.2_Missense_Mutation_p.E170K|XIRP2_ENST00000420519.1_Missense_Mutation_p.E170K|XIRP2_ENST00000295237.9_Missense_Mutation_p.E170K|XIRP2_ENST00000409728.1_Missense_Mutation_p.E170K|XIRP2_ENST00000409043.1_Missense_Mutation_p.E170K|XIRP2-AS1_ENST00000525330.1_RNA	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GAAAGGCAAGGAAACATCTTT	0.438000													21	56					0	0	0.639603	0	0
BARHL2	343472	broad.mit.edu	37	1	91180150	91180150	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:91180150C>T	ENST00000370445.4	-	2	830	c.789G>A	c.(787-789)atG>atA	p.M263I		NM_020063.1	NP_064447.1	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	263						nucleus	sequence-specific DNA binding			cervix(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		CAGCCAGGTCCATGCGATCCT	0.567000													52	19					0	0	0.870114	0	0
DCLK3	85443	broad.mit.edu	37	3	36779466	36779466	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:36779466G>A	ENST00000416516.2	-	2	1175	c.685C>T	c.(685-687)Cca>Tca	p.P229S		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	229						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity	p.P229A(1)		breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						TGATCCTCTGGGCCTCTGTCC	0.572000													36	38					0	0	0.853193	0	0
RAI1	10743	broad.mit.edu	37	17	17700963	17700963	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:17700963C>T	ENST00000353383.1	+	3	5170	c.4701C>T	c.(4699-4701)ccC>ccT	p.P1567P	RAI1_ENST00000261641.6_Silent_p.P1567P	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1567						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		AGGTGCTGCCCCTGGATCCCG	0.637000													13	46					0	0	0.457914	0	0
BCL2L12	83596	broad.mit.edu	37	19	50169132	50169132	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:50169132C>T	ENST00000246785.3	+	1	310	c.52C>T	c.(52-54)Cgg>Tgg	p.R18W	BCL2L12_ENST00000441864.2_Missense_Mutation_p.R18W|IRF3_ENST00000377139.3_5'UTR|BCL2L12_ENST00000246784.3_Missense_Mutation_p.R18W	NM_001040668.1|NM_138639.1	NP_001035758.1|NP_619580.1	Q9HB09	B2L12_HUMAN	BCL2-like 12 (proline rich)	18					apoptosis					central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	8		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.000681)|GBM - Glioblastoma multiforme(134;0.0214)		TTTGGGTTTCCGGCCAGAGGC	0.577000													6	34					0	0	0.248553	0	0
TRIM26	7726	broad.mit.edu	37	6	30164359	30164359	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:30164359G>A	ENST00000454678.2	-	6	1135	c.699C>T	c.(697-699)gcC>gcT	p.A233A	TRIM26_ENST00000453195.1_Silent_p.A233A|TRIM26_ENST00000437089.1_Silent_p.A233A	NM_003449.4	NP_003440.1	Q12899	TRI26_HUMAN	tripartite motif containing 26	233							DNA binding|zinc ion binding			lung(1)|ovary(2)	3						GGGCCAGCCGGGCAAGCTCCC	0.687000													32	47					0	0	0.804634	0	0
ZNF598	90850	broad.mit.edu	37	16	2049609	2049609	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:2049609G>A	ENST00000563630.1	-	9	2018	c.1776C>T	c.(1774-1776)ccC>ccT	p.P592P	ZNF598_ENST00000562103.1_Silent_p.P592P|ZNF598_ENST00000431526.1_Silent_p.P647P			Q86UK7	ZN598_HUMAN	zinc finger protein 598	647						intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						GGGGTTCCTTGGGGGCACTCC	0.716000													12	4					0	0	0.435327	0	0
FAM135B	51059	broad.mit.edu	37	8	139165196	139165196	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:139165196G>A	ENST00000395297.1	-	13	1692	c.1522C>T	c.(1522-1524)Caa>Taa	p.Q508*		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	508								p.Q508*(2)		NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCTTTGTTTTGAAATTCACCA	0.438000										HNSCC(54;0.14)			32	81					0	0	0.812448	0	0
OR10J1	26476	broad.mit.edu	37	1	159409937	159409937	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:159409937G>A	ENST00000423932.3	+	1	426	c.389G>A	c.(388-390)gGa>gAa	p.G130E	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	130					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					ACAGCAATGGGATATGACCGC	0.502000													69	23					0	0	0.870114	0	0
ARHGAP44	9912	broad.mit.edu	37	17	12812271	12812271	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:12812271G>A	ENST00000379672.5	+	4	556	c.256G>A	c.(256-258)Gga>Aga	p.G86R	ARHGAP44_ENST00000340825.3_Missense_Mutation_p.G86R|ARHGAP44_ENST00000262444.9_Missense_Mutation_p.G86R	NM_014859.4	NP_055674.4	Q17R89	RHG44_HUMAN	Rho GTPase activating protein 44	86	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|urinary_tract(1)	31						AGCTATCCTGGGAGATGACAC	0.468000													49	160					0	0	0.870114	0	0
CADPS	8618	broad.mit.edu	37	3	62423880	62423880	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:62423880C>T	ENST00000383710.4	-	28	4025	c.3676G>A	c.(3676-3678)Ggg>Agg	p.G1226R	CADPS_ENST00000283269.9_Missense_Mutation_p.G1187R|CADPS_ENST00000357948.3_Missense_Mutation_p.G1147R	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	1226	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		ACGTCCATCCCGGGTTTCTGT	0.463000													14	25					0	0	0.435327	0	0
MYO1F	4542	broad.mit.edu	37	19	8606866	8606866	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:8606866C>T	ENST00000338257.8	-	15	1801	c.1534G>A	c.(1534-1536)Gac>Aac	p.D512N		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	512	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity	p.D512N(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CCGCTGACGTCGTAGGAGACC	0.612000													6	29					0	0	0.217242	0	0
TNRC6C	57690	broad.mit.edu	37	17	76083070	76083070	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:76083070C>T	ENST00000335749.4	+	13	4258	c.3689C>T	c.(3688-3690)tCg>tTg	p.S1230L	TNRC6C_ENST00000541771.1_Missense_Mutation_p.S1233L|TNRC6C_ENST00000588847.1_Missense_Mutation_p.S1230L|TNRC6C_ENST00000588061.1_Missense_Mutation_p.S1233L|TNRC6C_ENST00000301624.4_Missense_Mutation_p.S1233L|TNRC6C_ENST00000544502.1_Missense_Mutation_p.S1230L	NM_001142640.1	NP_001136112.1	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C	1233	Pro-rich.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GCAGGCAAATCGGCCATGGAC	0.657000													12	37					0	0	0.457914	0	0
DLL1	28514	broad.mit.edu	37	6	170594204	170594204	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:170594204G>A	ENST00000366756.3	-	8	1385	c.1052C>T	c.(1051-1053)tCc>tTc	p.S351F		NM_005618.3	NP_005609.3	O00548	DLL1_HUMAN	delta-like 1 (Drosophila)	351	EGF-like 4; calcium-binding (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			NS(2)|breast(1)|endometrium(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	33		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		GCAGGTACAGGAGTAGCTGTT	0.562000													11	18					0	0	0.411799	0	0
QRICH1	54870	broad.mit.edu	37	3	49069662	49069662	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:49069662G>A	ENST00000395443.2	-	9	2564	c.2092C>T	c.(2092-2094)Cca>Tca	p.P698S	QRICH1_ENST00000357496.2_Missense_Mutation_p.P698S|QRICH1_ENST00000424300.1_Missense_Mutation_p.P698S	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	698										breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CATCTCAATGGATTCTCTGGA	0.458000													32	35					0	0	0.847076	0	0
ARRDC5	645432	broad.mit.edu	37	19	4891357	4891357	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:4891357G>A	ENST00000381781.2	-	3	729	c.730C>T	c.(730-732)Cgg>Tgg	p.R244W		NM_001080523.1	NP_001073992.1	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	244					signal transduction					endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		CTGTCCAGCCGAGACCGCCGC	0.592000													9	16					0	0	0.361761	0	0
APLP1	333	broad.mit.edu	37	19	36364607	36364607	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:36364607C>T	ENST00000221891.4	+	8	1240	c.1048C>T	c.(1048-1050)Ctg>Ttg	p.L350L	APLP1_ENST00000586861.1_Silent_p.L344L|APLP1_ENST00000537454.2_Silent_p.L311L	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	350					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CAGACAGGCCCTGAATGAGGT	0.587000													15	17					0	0	0.500413	0	0
NOS1	4842	broad.mit.edu	37	12	117768779	117768779	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:117768779C>T	ENST00000317775.6	-	2	781	c.96G>A	c.(94-96)gtG>gtA	p.V32V	NOS1_ENST00000344089.3_Silent_p.V32V|NOS1_ENST00000338101.4_Silent_p.V32V	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	32	Interaction with NOSIP (By similarity).|PDZ.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CCCGCTCCTTCACCAGAAATC	0.552000													16	25					0	0	0.539581	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806033	97806033	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:97806033G>A	ENST00000358642.2	+	1	17	c.17G>A	c.(16-18)gGa>gAa	p.G6E		NM_054106.1	NP_473447.1	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC, member 2	6					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	28						ATATCAGAGGGAAATAAGACT	0.373000													51	91					0	0	0.870114	0	0
TRPM6	140803	broad.mit.edu	37	9	77343174	77343174	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:77343174G>A	ENST00000451710.3	-	37	6165	c.5928C>T	c.(5926-5928)tgC>tgT	p.C1976C	TRPM6_ENST00000360774.1_Silent_p.C1972C|TRPM6_ENST00000449912.2_Silent_p.C1967C|TRPM6_ENST00000376871.3_Silent_p.C809C|TRPM6_ENST00000376872.3_Silent_p.C927C|TRPM6_ENST00000361255.3_Silent_p.C1967C			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1972	Alpha-type protein kinase.				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TGAGCTTCCGGCAGCAGGAGT	0.403000													44	11					0	0	0.870114	0	0
MRPS23	51649	broad.mit.edu	37	17	55926750	55926750	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:55926750G>A	ENST00000313608.8	-	2	111	c.66C>T	c.(64-66)gcC>gcT	p.A22A	MRPS23_ENST00000578444.1_Silent_p.A22A	NM_016070.3	NP_057154.2	Q9Y3D9	RT23_HUMAN	mitochondrial ribosomal protein S23	22					translation	intermediate filament cytoskeleton|mitochondrion|nuclear membrane|ribosome	structural constituent of ribosome			endometrium(2)|large_intestine(1)|lung(2)	5	Breast(9;8.75e-08)					TCAGCACCCCGGCCCGAACCA	0.582000													13	31					0	0	0.435327	0	0
CORIN	10699	broad.mit.edu	37	4	47676496	47676496	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:47676496C>T	ENST00000273857.4	-	10	1270	c.1271G>A	c.(1270-1272)gGa>gAa	p.G424E	CORIN_ENST00000508498.1_Missense_Mutation_p.G285E|CORIN_ENST00000505909.1_Missense_Mutation_p.G387E|CORIN_ENST00000502252.1_Missense_Mutation_p.G357E|CORIN_ENST00000504584.1_Missense_Mutation_p.G387E	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	424					peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						TCTTTGGTCTCCTTCTTGACA	0.433000													45	15					0	0	0.870114	0	0
ZNF80	7634	broad.mit.edu	37	3	113955276	113955276	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:113955276G>T	ENST00000482457.2	-	1	1149	c.646C>A	c.(646-648)Ccc>Acc	p.P216T		NM_007136.3	NP_009067.2	P51504	ZNF80_HUMAN	zinc finger protein 80	216						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|urinary_tract(2)	32		Lung NSC(201;0.0233)|all_neural(597;0.0837)				CACTCGTAGGGCTTTCCTGCA	0.493000													33	58					4.44401e-20	4.50842e-20	0.853193	1	0
CACNA1G	8913	broad.mit.edu	37	17	48649268	48649268	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:48649268G>A	ENST00000352832.5	+	5	988	c.616G>A	c.(616-618)Gat>Aat	p.D206N	CACNA1G_ENST00000515765.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000512389.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000503485.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000507896.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000515165.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000416767.4_Missense_Mutation_p.D206N|CACNA1G_ENST00000507510.2_Missense_Mutation_p.D206N|CACNA1G_ENST00000514717.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000507336.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000515411.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000510115.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000502264.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000360761.4_Missense_Mutation_p.D206N|CACNA1G_ENST00000507609.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000514079.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000513964.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000429973.2_Missense_Mutation_p.D206N|CACNA1G_ENST00000354983.4_Missense_Mutation_p.D206N|CACNA1G_ENST00000514181.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000505165.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000510366.1_Missense_Mutation_p.D206N|CACNA1G_ENST00000442258.2_Missense_Mutation_p.D206N|CACNA1G_ENST00000358244.5_Missense_Mutation_p.D206N|CACNA1G_ENST00000513689.2_Missense_Mutation_p.D206N|CACNA1G_ENST00000359106.5_Missense_Mutation_p.D206N	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	206					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GTTGCTGCTGGATACGCTGCC	0.647000													20	54					0	0	0.717897	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501427	90501427	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:90501427C>T	ENST00000325643.5	+	4	2091	c.2025C>T	c.(2023-2025)ctC>ctT	p.L675L		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		AGCAGGCCCTCTTGCCCTCCC	0.612000													14	8					0	0	0.479597	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762616	130762616	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:130762616C>T	ENST00000392429.1	+	2	3427	c.1049C>T	c.(1048-1050)tCc>tTc	p.S350F	TMEM200A_ENST00000545622.1_Missense_Mutation_p.S350F|TMEM200A_ENST00000296978.3_Missense_Mutation_p.S350F	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	350						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		AGGAATAATTCCATTGGGGAG	0.522000													26	36					0	0	0.693898	0	0
WNK1	65125	broad.mit.edu	37	12	994397	994397	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:994397C>T	ENST00000537687.1	+	19	5850	c.5207C>T	c.(5206-5208)tCt>tTt	p.S1736F	WNK1_ENST00000535572.1_Missense_Mutation_p.S1229F|WNK1_ENST00000340908.4_Missense_Mutation_p.S1069F|WNK1_ENST00000530271.2_Missense_Mutation_p.S1974F|WNK1_ENST00000315939.6_Missense_Mutation_p.S1476F	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1476					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GCTGTAGTATCTCAGCAGGCA	0.512000													24	44					0	0	0.693898	0	0
HK3	3101	broad.mit.edu	37	5	176308809	176308809	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:176308809G>A	ENST00000292432.5	-	17	2368	c.2277C>T	c.(2275-2277)atC>atT	p.I759I		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	759	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTGGCGGACGATCTCCCCCA	0.567000													27	14					0	0	0.740014	0	0
ELAVL3	1995	broad.mit.edu	37	19	11569051	11569051	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:11569051C>T	ENST00000359227.3	-	5	962	c.538G>A	c.(538-540)Gaa>Aaa	p.E180K	ELAVL3_ENST00000438662.2_Missense_Mutation_p.E180K	NM_001420.3|NM_032281.2	NP_001411.2|NP_115657.2	Q14576	ELAV3_HUMAN	ELAV like neuron-specific RNA binding protein 3	180	RRM 2.				cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15						ATAGCCTCTTCGGCCTCAATC	0.597000													6	48					0	0	0.307466	0	0
OR11L1	391189	broad.mit.edu	37	1	248004539	248004539	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:248004539G>A	ENST00000355784.2	-	1	715	c.660C>T	c.(658-660)ttC>ttT	p.F220F		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGGACACAATGAAAACATAGG	0.488000													29	8					0	0	0.740014	0	0
APCDD1	147495	broad.mit.edu	37	18	10471849	10471849	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:10471849C>T	ENST00000355285.4	+	3	919	c.565C>T	c.(565-567)Ctc>Ttc	p.L189F	APCDD1_ENST00000584596.1_3'UTR|APCDD1_ENST00000578882.1_Intron	NM_153000.4	NP_694545.1	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	189					hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				READ - Rectum adenocarcinoma(15;0.08)		GGCCTATGACCTCTGGCGAGA	0.622000													38	76					0	0	0.859065	0	0
PTPRN	5798	broad.mit.edu	37	2	220155547	220155547	+	Splice_Site	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:220155547C>T	ENST00000295718.2	-	21	3035		c.e21+1		PTPRN_ENST00000409251.3_Splice_Site|PTPRN_ENST00000423636.2_Splice_Site|PTPRN_ENST00000497977.1_Splice_Site	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N						response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		AAGCTCCCTACCTTTTGCCAT	0.587000													16	76					0	0	0.557998	0	0
NPAP1	23742	broad.mit.edu	37	15	24922455	24922455	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:24922455G>A	ENST00000329468.2	+	1	1915	c.1441G>A	c.(1441-1443)Gga>Aga	p.G481R		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TAATGAGAAAGGAGGCTCTTA	0.498000													34	118					0	0	0.796494	0	0
IGHV1-45	28466	broad.mit.edu	37	14	106963025	106963025	+	RNA	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:106963025C>T	ENST00000390621.2	-	0	314																											AATGGTGACTCTGTCCTGGAA	0.527000													61	37					0	0	0.870114	0	0
PRR12	57479	broad.mit.edu	37	19	50118189	50118189	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:50118189C>T	ENST00000418929.2	+	8	4959	c.4947C>T	c.(4945-4947)ttC>ttT	p.F1649F		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	828							DNA binding	p.F829F(1)|p.F1649F(1)		NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		ATGTAAAGTTCCTGGAAAATG	0.512000													18	14					0	0	0.575678	0	0
SERPINI2	5276	broad.mit.edu	37	3	167167187	167167187	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:167167187G>A	ENST00000476257.1	-	8	1266	c.968C>T	c.(967-969)tCa>tTa	p.S323L	SERPINI2_ENST00000461846.1_Missense_Mutation_p.S323L|SERPINI2_ENST00000471111.1_Missense_Mutation_p.S323L|SERPINI2_ENST00000264677.4_Missense_Mutation_p.S323L			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	323					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						CACTTCAGATGAATCTGGTTA	0.294000													6	8					0	0	0.217242	0	0
KSR1	8844	broad.mit.edu	37	17	25936329	25936329	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:25936329G>A	ENST00000398988.3	+	18	2299	c.1854G>A	c.(1852-1854)ggG>ggA	p.G618G	KSR1_ENST00000268763.6_Silent_p.G618G|KSR1_ENST00000509603.2_Silent_p.G733G|KSR1_ENST00000319524.6_Silent_p.G755G	NM_014238.1	NP_055053.1	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	753	Protein kinase.				Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GGCTGTTTGGGATCTCAGGCG	0.537000													87	96					0	0	0.870114	0	0
ACSM4	341392	broad.mit.edu	37	12	7480886	7480886	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:7480886G>A	ENST00000399422.4	+	13	1708	c.1660G>A	c.(1660-1662)Gaa>Aaa	p.E554K		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	554					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						CAATTAGGTGGAATTTGTTCA	0.398000													3	2					0	0	0.115264	0	0
SEMA4B	10509	broad.mit.edu	37	15	90768389	90768389	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:90768389G>A	ENST00000411539.2	+	10	1644	c.1384G>A	c.(1384-1386)Gat>Aat	p.D462N	SEMA4B_ENST00000332496.6_Missense_Mutation_p.D462N|SEMA4B_ENST00000379122.3_Missense_Mutation_p.D457N	NM_198925.2	NP_945119.1			sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B											NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)	12	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			CCACACCTACGATGTCCTCTT	0.672000													7	2					0	0	0.278610	0	0
SHPRH	257218	broad.mit.edu	37	6	146262942	146262942	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:146262942G>A	ENST00000367503.3	-	10	2705	c.2307C>T	c.(2305-2307)atC>atT	p.I769I	SHPRH_ENST00000275233.7_Silent_p.I769I|SHPRH_ENST00000438092.2_Silent_p.I769I|SHPRH_ENST00000367505.2_Silent_p.I769I	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	769	Helicase ATP-binding; second part.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CATAGGTAATGATAACTATAT	0.393000													10	21					0	0	0.387290	0	0
ATG13	9776	broad.mit.edu	37	11	46685607	46685607	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:46685607C>T	ENST00000528494.1	+	11	1154	c.850C>T	c.(850-852)Ctg>Ttg	p.L284L	ATG13_ENST00000526508.1_Intron|ATG13_ENST00000530500.1_Intron|ATG13_ENST00000524625.1_Intron|ATG13_ENST00000434074.1_Intron|ATG13_ENST00000359513.4_Intron|ATG13_ENST00000312040.4_Intron|ATG13_ENST00000451945.1_Intron|ATG13_ENST00000529655.1_Intron	NM_001205119.1	NP_001192048.1	O75143	ATG13_HUMAN	autophagy related 13	262					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	15						GACGGACACCCTGAGGGTCCC	0.453000													50	118					0	0	0.870114	0	0
DAGLA	747	broad.mit.edu	37	11	61503050	61503050	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:61503050C>T	ENST00000257215.5	+	11	1262	c.1146C>T	c.(1144-1146)ttC>ttT	p.F382F		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	382					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		AAACGCCCTTCTACGTGGCGG	0.637000													22	4					0	0	0.693898	0	0
ECT2L	345930	broad.mit.edu	37	6	139167687	139167687	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:139167687C>T	ENST00000423192.1	+	7	937	c.776C>T	c.(775-777)tCt>tTt	p.S259F	ECT2L_ENST00000367682.2_Missense_Mutation_p.S259F|ECT2L_ENST00000541398.1_Missense_Mutation_p.S190F			Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2 oncogene-like	259					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(1)	30						AGCAATATTTCTGGAAGCCAT	0.368000			"""N, Splice, Mis"""		ETP ALL								10	26					0	0	0.335167	0	0
FGF14	2259	broad.mit.edu	37	13	102379096	102379096	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr13:102379096G>A	ENST00000376131.4	-	4	583	c.488C>T	c.(487-489)tCa>tTa	p.S163L	FGF14_ENST00000376143.4_Missense_Mutation_p.S158L	NM_175929.2	NP_787125.1	Q92915	FGF14_HUMAN	fibroblast growth factor 14	158					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)	29	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CAACATGGATGAGTAGATTAC	0.358000													12	11					0	0	0.435327	0	0
DHX57	90957	broad.mit.edu	37	2	39055483	39055483	+	Splice_Site	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:39055483G>A	ENST00000295373.6	-	14	2764	c.2639_splice	c.e14+1	p.R880_splice		NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	880	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TTAGCTTACCGATTACTACGT	0.388000													24	20					0	0	0.667858	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:115256529T>C	ENST00000369535.4	-	3	435	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(817)|p.Q61L(175)|p.Q61P(23)|p.Q61K(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			91	42					0	0	0.870114	0	0
OPN1SW	611	broad.mit.edu	37	7	128413867	128413867	+	Missense_Mutation	SNP	C	C	T	rs138093200		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:128413867C>T	ENST00000249389.2	-	4	762	c.763G>A	c.(763-765)Gta>Ata	p.V255I		NM_001708.2	NP_001699.1	P03999	OPSB_HUMAN	opsin 1 (cone pigments), short-wave-sensitive	255					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|stomach(1)	19						AAGGATCCTACCATCACAACC	0.577000													19	29					0	0	0.575678	0	0
CD207	50489	broad.mit.edu	37	2	71060134	71060134	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:71060134T>A	ENST00000410009.3	-	4	659	c.614A>T	c.(613-615)aAc>aTc	p.N205I		NM_015717.3	NP_056532.3	Q9UJ71	CLC4K_HUMAN	CD207 molecule, langerin	205	C-type lectin.				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|stomach(1)	20						GTAATAGAAGTTCCCCTTGAA	0.448000													24	16					0	0	0.693898	0	0
LEKR1	389170	broad.mit.edu	37	3	156763413	156763413	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:156763413G>A	ENST00000470811.1	+	14	2376	c.1041G>A	c.(1039-1041)ccG>ccA	p.P347P	LEKR1_ENST00000356539.4_Silent_p.P651P			D3DNK7	D3DNK7_HUMAN	leucine, glutamate and lysine rich 1	0										breast(1)|large_intestine(5)|lung(3)|ovary(1)|skin(1)	11			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CAGATAAGCCGAAGAGGGTTA	0.532000													71	70					0	0	0.870114	0	0
IER5L	389792	broad.mit.edu	37	9	131939648	131939648	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:131939648G>A	ENST00000372491.2	-	1	892	c.684C>T	c.(682-684)gcC>gcT	p.A228A	RP11-247A12.8_ENST00000599172.2_RNA|RP11-247A12.2_ENST00000372490.3_RNA	NM_203434.2	NP_982258.2	Q5T953	IER5L_HUMAN	immediate early response 5-like	228	Ala-rich.												Ovarian(14;0.0448)|Medulloblastoma(224;0.235)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)		aggaggcgggggccggggagg	0.771000													15	5					0	0	0.557998	0	0
NOS3	4846	broad.mit.edu	37	7	150698379	150698379	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:150698379G>A	ENST00000297494.3	+	11	1651	c.1294G>A	c.(1294-1296)Gag>Aag	p.E432K	NOS3_ENST00000461406.1_Missense_Mutation_p.E226K|NOS3_ENST00000467517.1_Missense_Mutation_p.E432K|NOS3_ENST00000484524.1_Missense_Mutation_p.E432K	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	432	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GAAGCACCTGGAGAATGAGCA	0.622000													47	65					0	0	0.870114	0	0
DLGAP1	9229	broad.mit.edu	37	18	3581882	3581882	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:3581882G>A	ENST00000315677.3	-	8	2551	c.1956C>T	c.(1954-1956)atC>atT	p.I652I	DLGAP1_ENST00000584874.1_Silent_p.I652I|DLGAP1_ENST00000581699.1_Silent_p.I358I|DLGAP1_ENST00000515196.2_Silent_p.I652I|DLGAP1_ENST00000534970.1_Silent_p.I336I|DLGAP1_ENST00000400155.1_Silent_p.I358I|DLGAP1_ENST00000581527.1_Silent_p.I652I|DLGAP1_ENST00000400150.3_Silent_p.I368I|DLGAP1_ENST00000400149.3_Silent_p.I342I|DLGAP1_ENST00000400145.2_Silent_p.I350I|DLGAP1_ENST00000539435.1_Silent_p.I360I|DLGAP1_ENST00000400147.2_Silent_p.I350I	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	652	Interaction with DYL2 (By similarity).				synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				CCTGTATCCCGATAGACAGGC	0.458000													24	43					0	0	0.740014	0	0
RFX6	222546	broad.mit.edu	37	6	117243285	117243285	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:117243285G>A	ENST00000332958.2	+	13	1424	c.1408G>A	c.(1408-1410)Gat>Aat	p.D470N		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	470					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						TGAATGGTTGGATACTGTGGT	0.343000													17	32					0	0	0.624587	0	0
COL4A1	1282	broad.mit.edu	37	13	110813568	110813568	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr13:110813568C>T	ENST00000375820.4	-	49	4732	c.4611G>A	c.(4609-4611)acG>acA	p.T1537T	COL4A1_ENST00000467182.1_5'UTR	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1537	Collagen IV NC1.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TGTTTTCCCCCGTGATGGGTG	0.448000													3	48					0	0	0.184627	0	0
CHRNA3	1136	broad.mit.edu	37	15	78909424	78909424	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:78909424C>T	ENST00000326828.5	-	4	703	c.319G>A	c.(319-321)Gag>Aag	p.E107K	CHRNA3_ENST00000348639.3_Missense_Mutation_p.E107K	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	107					activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CGCATGAACTCTGCCCCACCA	0.552000													8	33					0	0	0.387290	0	0
NECAP1	25977	broad.mit.edu	37	12	8245546	8245546	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:8245546C>T	ENST00000339754.5	+	6	649	c.571C>T	c.(571-573)Cca>Tca	p.P191S		NM_015509.3	NP_056324.2	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	191					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				cervix(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				Kidney(36;0.0915)		CCCACCCCCGCCAGGAGGCAA	0.512000													121	152					0	0	0.870114	0	0
ZNF714	148206	broad.mit.edu	37	19	21300028	21300028	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:21300028C>T	ENST00000596143.1	+	5	883	c.558C>T	c.(556-558)acC>acT	p.T186T	ZNF714_ENST00000291770.7_3'UTR|ZNF714_ENST00000596053.1_Intron|ZNF714_ENST00000601416.1_3'UTR	NM_182515.3	NP_872321.2	Q96N38	ZN714_HUMAN	zinc finger protein 714	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|urinary_tract(2)	18						GGTTCTCAACCCTTACTAGAC	0.368000													23	31					0	0	0.667858	0	0
IFT57	55081	broad.mit.edu	37	3	107940986	107940986	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:107940986G>A	ENST00000264538.3	-	1	431	c.184C>T	c.(184-186)Cgg>Tgg	p.R62W		NM_018010.3	NP_060480.1	Q9NWB7	IFT57_HUMAN	intraflagellar transport 57 homolog (Chlamydomonas)	62					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	14			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			TTGCTCTTCCGGAGGAACTCC	0.682000													5	8					0	0	0.248553	0	0
GPR64	10149	broad.mit.edu	37	X	19028764	19028764	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:19028764G>A	ENST00000354791.3	-	16	1425	c.1184C>T	c.(1183-1185)tCc>tTc	p.S395F	GPR64_ENST00000340581.3_Missense_Mutation_p.S381F|GPR64_ENST00000356606.4_Missense_Mutation_p.S397F|GPR64_ENST00000357991.3_Missense_Mutation_p.S408F|GPR64_ENST00000379869.3_Missense_Mutation_p.S411F|GPR64_ENST00000379873.2_Missense_Mutation_p.S411F|GPR64_ENST00000379876.1_Missense_Mutation_p.S387F|GPR64_ENST00000379878.3_Missense_Mutation_p.S395F|GPR64_ENST00000357544.3_Missense_Mutation_p.S381F|GPR64_ENST00000360279.4_Missense_Mutation_p.S389F			Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64	411					neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(18)|stomach(1)|urinary_tract(1)	42	Hepatocellular(33;0.183)					GTCAGGCGGGGAATGAAGGAG	0.537000													11	92					0	0	0.520397	0	0
ADAM28	10863	broad.mit.edu	37	8	24188792	24188792	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:24188792G>A	ENST00000265769.4	+	12	1343	c.1233G>A	c.(1231-1233)ggG>ggA	p.G411G	RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000540823.1_Silent_p.G178G|ADAM28_ENST00000518516.1_3'UTR|ADAM28_ENST00000397649.3_Silent_p.G158G|RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000437154.2_Silent_p.G411G|RP11-624C23.1_ENST00000523700.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	411	Disintegrin.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CAATTTGTGGGAACCAGTTGG	0.408000													16	30					0	0	0.557998	0	0
UHRF1	29128	broad.mit.edu	37	19	4954832	4954832	+	RNA	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:4954832C>T	ENST00000592666.1	+	0	2704							Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains 1						cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(2)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		AGCGGCAGCCCGGTAGGCTCG	0.597000													7	26					0	0	0.387290	0	0
OPLAH	26873	broad.mit.edu	37	8	145112555	145112555	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:145112555G>A	ENST00000426825.1	-	10	1299	c.1218C>T	c.(1216-1218)ttC>ttT	p.F406F	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	406							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	AAATGCAGGGGAAGGAGGCAG	0.642000													4	35					0	0	0.217242	0	0
SDR16C5	195814	broad.mit.edu	37	8	57218206	57218206	+	Silent	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:57218206T>C	ENST00000396721.2	-	5	784	c.654A>G	c.(652-654)aaA>aaG	p.K218K	SDR16C5_ENST00000522671.1_Silent_p.K262K|SDR16C5_ENST00000303749.3_Silent_p.K262K			Q8N3Y7	RDHE2_HUMAN	short chain dehydrogenase/reductase family 16C, member 5	262					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)	16						ACAAGTACATTTTTTCTTGTA	0.318000													17	17					0	0	0.592651	0	0
C20orf96	140680	broad.mit.edu	37	20	259840	259840	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:259840G>A	ENST00000360321.2	-	5	576	c.438C>T	c.(436-438)gcC>gcT	p.A146A	C20orf96_ENST00000400269.3_Silent_p.A88A|C20orf96_ENST00000382369.5_Silent_p.A111A	NM_080571.1|NM_153269.2	NP_542138.1|NP_695001.2	Q9NUD7	CT096_HUMAN	chromosome 20 open reading frame 96	146										endometrium(3)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	12		all_cancers(10;0.00959)|Lung NSC(37;0.227)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			GCTGCAGCAGGGCCCGCACGT	0.677000													7	37					0	0	0.361761	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555079	44555079	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:44555079C>T	ENST00000330682.2	-	1	1370	c.1135G>A	c.(1135-1137)Gag>Aag	p.E379K	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000245121.5_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	379	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						TTGTCTTTCTCTGTGCGGTAC	0.557000													20	803					0	0	0.575678	0	0
PLCZ1	89869	broad.mit.edu	37	12	18854670	18854670	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:18854670C>T	ENST00000447925.2	-	8	1168	c.899G>A	c.(898-900)gGa>gAa	p.G300E	PLCZ1_ENST00000542762.1_5'UTR|PLCZ1_ENST00000435379.1_Missense_Mutation_p.G107E|PLCZ1_ENST00000541695.1_Missense_Mutation_p.G165E|PLCZ1_ENST00000538330.1_Missense_Mutation_p.G43E|PLCZ1_ENST00000539875.1_Missense_Mutation_p.G109E|PLCZ1_ENST00000266505.7_Missense_Mutation_p.G302E	NM_033123.2	NP_149114.2	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	302					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					CTTTAAGGTTCCTATTTTCTT	0.363000													4	6					0	0	0.248553	0	0
OR1J1	347168	broad.mit.edu	37	9	125239735	125239735	+	Silent	SNP	A	A	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:125239735A>C	ENST00000259357.2	-	1	500	c.471T>G	c.(469-471)ctT>ctG	p.L157L		NM_001004451.1	NP_001004451.1	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J, member 1	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	16						GGGTATGCAAAAGAGCACACG	0.547000													10	5					0	0	0.387290	0	0
POF1B	79983	broad.mit.edu	37	X	84537226	84537226	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:84537226C>T	ENST00000262753.4	-	16	1892	c.1747G>A	c.(1747-1749)Gaa>Aaa	p.E583K	POF1B_ENST00000373145.3_Missense_Mutation_p.E583K	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	583							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TATTTGTCTTCTGTTTTCTCA	0.358000													5	23					0	0	0.307466	0	0
DYNAP	284254	broad.mit.edu	37	18	52265112	52265112	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:52265112G>A	ENST00000321600.1	+	3	415	c.369G>A	c.(367-369)gtG>gtA	p.V123V	DYNAP_ENST00000585973.1_Silent_p.V71V	NM_173629.1	NP_775900.1			dynactin associated protein																		TAGCCTGTGTGATAATGACAG	0.383000													31	52					0	0	0.827153	0	0
ZCCHC16	340595	broad.mit.edu	37	X	111698178	111698178	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:111698178C>T	ENST00000340433.2	+	1	452	c.222C>T	c.(220-222)ttC>ttT	p.F74F		NM_001004308.2	NP_001004308.2	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	74							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27						GCTCAGAGTTCCTCACTCAGG	0.483000													22	19					0	0	0.706142	0	0
HERC6	55008	broad.mit.edu	37	4	89326115	89326115	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:89326115A>T	ENST00000380265.5	+	9	1363	c.1180A>T	c.(1180-1182)Aaa>Taa	p.K394*	HERC6_ENST00000264346.7_Nonsense_Mutation_p.K394*	NM_001165136.1	NP_001158608.1	Q8IVU3	HERC6_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	394					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		GATAGCAGTGAAAAGAAGAAG	0.433000													20	35					0	0	0.706142	0	0
ICAM2	3384	broad.mit.edu	37	17	62081230	62081230	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:62081230G>A	ENST00000412356.1	-	5	777	c.423C>T	c.(421-423)ccC>ccT	p.P141P	ICAM2_ENST00000418105.1_Silent_p.P141P|ICAM2_ENST00000578892.1_Silent_p.P117P|ICAM2_ENST00000578379.1_Silent_p.P40P|ICAM2_ENST00000449662.2_Silent_p.P141P|C17orf72_ENST00000412177.1_3'UTR|ICAM2_ENST00000579788.1_Silent_p.P141P|ICAM2_ENST00000581417.1_5'UTR|ICAM2_ENST00000579687.1_Silent_p.P141P	NM_001099786.1	NP_001093256.1	P13598	ICAM2_HUMAN	intercellular adhesion molecule 2	141	Ig-like C2-type 2.				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			large_intestine(1)|lung(2)|ovary(1)|skin(2)	6						GGCTGTCCAGGGGCTCCACGG	0.612000													26	19					0	0	0.750413	0	0
FAM63A	55793	broad.mit.edu	37	1	150971967	150971967	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:150971967G>A	ENST00000361936.5	-	8	1813	c.859C>T	c.(859-861)Ctg>Ttg	p.L287L	FAM63A_ENST00000493834.2_Silent_p.L192L|FAM63A_ENST00000361738.6_Silent_p.L335L|FAM63A_ENST00000312210.5_Silent_p.L145L|FAM63A_ENST00000470877.1_5'UTR	NM_018379.4	NP_060849.2	Q8N5J2	FA63A_HUMAN	family with sequence similarity 63, member A	287				L -> P (in Ref. 2; BAA92104).			protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GTGGTCTCCAGGAACTGCTCT	0.557000													142	33					0	0	0.870114	0	0
CYTIP	9595	broad.mit.edu	37	2	158272620	158272620	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:158272620C>T	ENST00000264192.3	-	8	770	c.649G>A	c.(649-651)Gac>Aac	p.D217N	CYTIP_ENST00000540637.1_Missense_Mutation_p.D111N	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	217					regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						TCATCCAAGTCCATGTTTTCC	0.473000													19	16					0	0	0.639603	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450224	105450224	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:105450224G>A	ENST00000337685.2	+	5	1584	c.799G>A	c.(799-801)Gct>Act	p.A267T	MUM1L1_ENST00000372552.1_Missense_Mutation_p.A267T|MUM1L1_ENST00000357175.2_Missense_Mutation_p.A267T	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	267										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						AGAGACCCTGGCTGTTCCCTC	0.463000													10	5					0	0	0.435327	0	0
C1orf168	199920	broad.mit.edu	37	1	57258315	57258315	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:57258315G>A	ENST00000343433.6	-	2	251	c.171C>T	c.(169-171)tcC>tcT	p.S57S	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	57										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						GCTTGTGGTTGGATGAGAGGG	0.458000													69	29					0	0	0.870114	0	0
RPS20	6224	broad.mit.edu	37	8	56985774	56985774	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:56985774G>A	ENST00000519807.1	-	4	360	c.235C>T	c.(235-237)Cgt>Tgt	p.R79C	RPS20_ENST00000520627.1_Missense_Mutation_p.R24C|RPS20_ENST00000519606.1_3'UTR|RPS20_ENST00000009589.3_Missense_Mutation_p.R79C|RPS20_ENST00000521262.1_Missense_Mutation_p.R79C|RPS20_ENST00000523936.1_3'UTR|RPS20_ENST00000524349.1_Missense_Mutation_p.R24C|RPS20_ENST00000520490.1_5'UTR	NM_001146227.1	NP_001139699.1	P60866	RS20_HUMAN	ribosomal protein S20	79					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome	p.R79C(1)					all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.155)	Epithelial(17;0.00117)|all cancers(17;0.00879)			ATCTGGAAACGATCCCACGTC	0.398000													39	49					0	0	0.870114	0	0
TNS4	84951	broad.mit.edu	37	17	38640799	38640799	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:38640799G>A	ENST00000254051.6	-	6	1596	c.1438C>T	c.(1438-1440)Cga>Tga	p.R480*		NM_032865.5	NP_116254.4	Q8IZW8	TENS4_HUMAN	tensin 4	480	SH2.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	30		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			AAGGAGCCTCGGTATGAAGAG	0.582000													5	11					0	0	0.248553	0	0
USH2A	7399	broad.mit.edu	37	1	216166467	216166467	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:216166467C>T	ENST00000366943.2	-	35	7086	c.6700G>A	c.(6700-6702)Gcc>Acc	p.A2234T	USH2A_ENST00000307340.3_Missense_Mutation_p.A2234T			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2234	Fibronectin type-III 8.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCAGTTAGGGCCTCACTGGCC	0.507000										HNSCC(13;0.011)	OREG0014251	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	73	16					0	0	0.870114	0	0
OR2AG2	338755	broad.mit.edu	37	11	6789911	6789911	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:6789911G>A	ENST00000338569.2	-	1	375	c.278C>T	c.(277-279)tCc>tTc	p.S93F		NM_001004490.1	NP_001004490.1	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG, member 2	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(13)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	28		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCCTCCAAAGGAGATAGTGTT	0.537000													36	10					0	0	0.812448	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55024677	55024677	+	Missense_Mutation	SNP	G	G	A	rs145545626		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:55024677G>A	ENST00000324000.3	+	3	2870	c.836G>A	c.(835-837)gGa>gAa	p.G279E		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	279					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	p.G279E(1)		breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		GCTTGGCCGGGAAATATAATG	0.408000													40	58					0	0	0.870114	0	0
DNAH5	1767	broad.mit.edu	37	5	13769652	13769652	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:13769652C>T	ENST00000265104.4	-	57	9782	c.9678G>A	c.(9676-9678)gcG>gcA	p.A3226A	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3226	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCTTTTCTTTCGCTTCCAGTT	0.433000									Kartagener syndrome				24	43					0	0	0.750413	0	0
GHR	2690	broad.mit.edu	37	5	42719517	42719517	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:42719517C>T	ENST00000230882.4	+	10	2098	c.1908C>T	c.(1906-1908)atC>atT	p.I636I	GHR_ENST00000537449.1_Silent_p.I449I|GHR_ENST00000357703.3_Silent_p.I614I	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	636					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TGAACAAAATCATGCCTTAGC	0.433000													45	17					0	0	0.870114	0	0
ATP6V0D2	245972	broad.mit.edu	37	8	87165108	87165108	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:87165108A>C	ENST00000285393.3	+	8	1097	c.955A>C	c.(955-957)Aag>Cag	p.K319Q	CTD-3118D11.2_ENST00000522679.1_RNA	NM_152565.1	NP_689778.1	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2	319					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|prostate(1)	27						TGCATATGTAAAGCTGAAGGA	0.353000													29	81					0	0	0.812448	0	0
TBC1D23	55773	broad.mit.edu	37	3	100002625	100002625	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:100002625T>A	ENST00000394144.4	+	4	453	c.446T>A	c.(445-447)tTt>tAt	p.F149Y	TBC1D23_ENST00000475134.1_Intron|TBC1D23_ENST00000486274.1_3'UTR|TBC1D23_ENST00000344949.5_Missense_Mutation_p.F149Y	NM_001199198.2	NP_001186127.1	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	149	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(10)|ovary(1)|prostate(2)|skin(2)	25						TACAACTGCTTTTATGCCATA	0.358000													39	63					0	0	0.870114	0	0
TLR7	51284	broad.mit.edu	37	X	12905625	12905625	+	Silent	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:12905625T>C	ENST00000380659.3	+	3	2137	c.1998T>C	c.(1996-1998)ccT>ccC	p.P666P		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	666					cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	GTTTCTTGCCTTCTGGAGTTT	0.348000													22	21					0	0	0.654019	0	0
KCNH8	131096	broad.mit.edu	37	3	19575158	19575158	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:19575158C>T	ENST00000328405.2	+	16	3157	c.2891C>T	c.(2890-2892)tCc>tTc	p.S964F		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	964	Ser-rich.					integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						GTGGATCCCTCCTCTGTGGGG	0.502000													42	57					0	0	0.870114	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147040965	147040965	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:147040965A>G	ENST00000265272.5	-	3	640	c.173T>C	c.(172-174)aTt>aCt	p.I58T	JAKMIP2_ENST00000333010.6_Missense_Mutation_p.I16T|JAKMIP2_ENST00000507386.1_Missense_Mutation_p.I58T	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	58						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCTCACGAATCCTCTTCGC	0.502000													39	16					0	0	0.870114	0	0
KRT4	3851	broad.mit.edu	37	12	53207481	53207481	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:53207481G>A	ENST00000551956.1	-	1	854	c.362C>T	c.(361-363)cCc>cTc	p.P121L	KRT4_ENST00000458244.2_Missense_Mutation_p.P101L|KRT4_ENST00000293774.4_Missense_Mutation_p.P195L			B4DRS2	B4DRS2_HUMAN	keratin 4	121						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						CACGTGGAGGGGGGTGAGCAA	0.582000													40	40					0	0	0.864702	0	0
GFM1	85476	broad.mit.edu	37	3	158376735	158376735	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:158376735T>C	ENST00000486715.1	+	9	1465	c.1108T>C	c.(1108-1110)Tat>Cat	p.Y370H	GFM1_ENST00000478576.1_Missense_Mutation_p.Y370H|GFM1_ENST00000264263.5_Missense_Mutation_p.Y389H	NM_024996.5	NP_079272.4	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1	370					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|urinary_tract(2)	22			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			ACAATTAACTTATGTTCGCAG	0.408000													27	30					0	0	0.779181	0	0
BIRC6	57448	broad.mit.edu	37	2	32640294	32640294	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:32640294C>T	ENST00000421745.2	+	10	2069	c.1935C>T	c.(1933-1935)atC>atT	p.I645I		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	645					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CAGGAAAGATCTTTTCACAGA	0.378000													11	18					0	0	0.457914	0	0
TUBE1	51175	broad.mit.edu	37	6	112393216	112393216	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:112393216G>A	ENST00000368662.5	-	11	1236	c.1158C>T	c.(1156-1158)tcC>tcT	p.S386S	TUBE1_ENST00000604814.1_5'UTR	NM_016262.4	NP_057346.1	Q9UJT0	TBE_HUMAN	tubulin, epsilon 1	386					centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			cervix(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	12		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		CAGGAGGTACGGAACACAGGC	0.413000													27	46					0	0	0.827153	0	0
COL22A1	169044	broad.mit.edu	37	8	139824127	139824127	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:139824127G>A	ENST00000303045.6	-	9	1810	c.1364C>T	c.(1363-1365)cCc>cTc	p.P455L	COL22A1_ENST00000435777.1_Missense_Mutation_p.P455L	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	455	Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTGGGGTGGGGGTGGAGGTGG	0.597000										HNSCC(7;0.00092)			11	2					0	0	0.435327	0	0
SHBG	6462	broad.mit.edu	37	17	7535056	7535056	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:7535056C>T	ENST00000380450.4	+	5	736	c.705C>T	c.(703-705)ttC>ttT	p.F235F	SHBG_ENST00000340624.5_Silent_p.F177F|SHBG_ENST00000574539.1_Silent_p.F177F|SHBG_ENST00000572262.1_Silent_p.F123F|SHBG_ENST00000572182.1_Intron|SHBG_ENST00000576728.1_Silent_p.F123F|SHBG_ENST00000575903.1_Silent_p.F217F|SHBG_ENST00000416273.3_Silent_p.F235F|SHBG_ENST00000576478.1_Silent_p.F123F|SHBG_ENST00000575314.1_Silent_p.F177F|SHBG_ENST00000441599.2_Silent_p.F235F|SHBG_ENST00000570547.1_Silent_p.F177F	NM_001040.3	NP_001031.2	P04278	SHBG_HUMAN	sex hormone-binding globulin	235	Laminin G-like 2.				hormone transport	extracellular region	androgen binding|protein homodimerization activity	p.0?(1)|p.?(1)		cervix(1)|endometrium(2)|large_intestine(4)|lung(2)|skin(1)	10		all_cancers(10;0.0867)		READ - Rectum adenocarcinoma(115;0.168)	Danazol(DB01406)|Dromostanolone(DB00858)|Estradiol(DB00783)|Estrone(DB00655)|Fluoxymesterone(DB01185)|Hydrocortisone(DB00741)|Mitotane(DB00648)|Norethindrone(DB00717)|Testosterone(DB00624)	AGGCAGAATTCAATCTCCGAG	0.547000													110	98					0	0	0.870114	0	0
PCED1B	91523	broad.mit.edu	37	12	47629014	47629014	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:47629014C>T	ENST00000546455.1	+	4	899	c.168C>T	c.(166-168)ttC>ttT	p.F56F	PCED1B_ENST00000432328.1_Silent_p.F56F					PC-esterase domain containing 1B																		AGCTGAACTTCGAACAAGATG	0.602000													13	26					0	0	0.435327	0	0
LRRC16A	55604	broad.mit.edu	37	6	25610296	25610296	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:25610296C>T	ENST00000329474.6	+	36	4234	c.3866C>T	c.(3865-3867)cCa>cTa	p.P1289L		NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1289					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						CCAGACTCTCCATCTAGCCCG	0.458000													30	159					0	0	0.812448	0	0
ING1	3621	broad.mit.edu	37	13	111371712	111371712	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr13:111371712C>T	ENST00000375774.3	+	2	1164	c.702C>T	c.(700-702)atC>atT	p.I234I	ING1_ENST00000375775.3_Silent_p.I22I|ING1_ENST00000338450.7_Silent_p.I47I|ING1_ENST00000333219.7_Silent_p.I91I|ING1_ENST00000464141.1_3'UTR	NM_005537.4	NP_005528.3	Q9UK53	ING1_HUMAN	inhibitor of growth family, member 1	234					cell cycle|negative regulation of cell growth|negative regulation of cell proliferation	nucleus	zinc ion binding			endometrium(4)|large_intestine(6)|lung(1)|ovary(1)	12	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.188)			AGATCCAGATCGTGAGCCAGA	0.672000													37	28					0	0	0.864702	0	0
SPATA5	166378	broad.mit.edu	37	4	124235123	124235123	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:124235123C>T	ENST00000274008.3	+	16	2655	c.2586C>T	c.(2584-2586)ttC>ttT	p.F862F		NM_145207.2	NP_660208.2	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	862					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24						AAAGACATTTCACTCAGGCCT	0.408000													24	6					0	0	0.667858	0	0
TTN	7273	broad.mit.edu	37	2	179547505	179547505	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:179547505G>A	ENST00000589042.1	-	135	33237	c.33013C>T	c.(33013-33015)Cca>Tca	p.P11005S	TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P9761S|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P10688S|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10688	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTCTGTTGGTTCATACTCC	0.368000													72	69					0	0	0.870114	0	0
FAM166A	401565	broad.mit.edu	37	9	140139596	140139596	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:140139596G>A	ENST00000344774.4	-	4	651	c.597C>T	c.(595-597)ttC>ttT	p.F199F	FAM166A_ENST00000388932.2_Silent_p.F199F	NM_001001710.1	NP_001001710.1	Q6J272	F166A_HUMAN	family with sequence similarity 166, member A	199										kidney(3)|lung(7)|ovary(2)|prostate(1)|urinary_tract(2)	15						GCAGCCGCTGGAAGCTGCCCA	0.677000													31	12					0	0	0.779181	0	0
SULT1A1	6817	broad.mit.edu	37	16	28631441	28631441	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:28631441G>A	ENST00000350842.4	-	2	469	c.81C>T	c.(79-81)ctC>ctT	p.L27L	SULT1A1_ENST00000395609.1_5'UTR	NM_177536.3	NP_803880.1	P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	0					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						CCTTTCCCTGGAGAATGCTCA	0.338000													10	12					0	0	0.435327	0	0
LRP1B	53353	broad.mit.edu	37	2	141072531	141072531	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:141072531C>T	ENST00000389484.3	-	83	13749	c.12778G>A	c.(12778-12780)Gga>Aga	p.G4260R		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4260	EGF-like 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAAGTTCCTCCATTCTGGCAG	0.363000										TSP Lung(27;0.18)			14	53					0	0	0.539581	0	0
CYP3A4	1576	broad.mit.edu	37	7	99367835	99367835	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:99367835C>T	ENST00000336411.2	-	5	525	c.342G>A	c.(340-342)atG>atA	p.M114I	CYP3A4_ENST00000354593.2_Intron	NM_001202855.2|NM_017460.5	NP_001189784.1|NP_059488.2	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 4	114					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			breast(3)|central_nervous_system(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TGGCACTTTTCATAAATCCCA	0.408000													24	38					0	0	0.729181	0	0
PARK2	5071	broad.mit.edu	37	6	161781175	161781175	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:161781175G>A	ENST00000366898.1	-	11	1332	c.1230C>T	c.(1228-1230)acC>acT	p.T410T	PARK2_ENST00000366897.1_Silent_p.T382T|PARK2_ENST00000338468.3_Silent_p.T219T|PARK2_ENST00000366894.1_Silent_p.T219T|PARK2_ENST00000366896.1_Silent_p.T261T	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	410					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		TTTTCTTGATGGTTTCTTTGG	0.517000													28	46					0	0	0.729181	0	0
LAMA1	284217	broad.mit.edu	37	18	6966156	6966156	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:6966156G>A	ENST00000389658.3	-	49	7133	c.7040C>T	c.(7039-7041)tCa>tTa	p.S2347L		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2347	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGTGCCGTATGAACCCAGGTA	0.428000													11	18					0	0	0.500413	0	0
EPHA7	2045	broad.mit.edu	37	6	94120594	94120594	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:94120594C>T	ENST00000369303.4	-	3	641	c.457G>A	c.(457-459)Gaa>Aaa	p.E153K	EPHA7_ENST00000369297.1_Missense_Mutation_p.E153K	NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	153						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GTAAAACTTTCATCTGCAGCA	0.373000													17	31					0	0	0.575678	0	0
PDLIM5	10611	broad.mit.edu	37	4	95583616	95583616	+	Silent	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:95583616T>C	ENST00000317968.4	+	12	1765	c.1629T>C	c.(1627-1629)ttT>ttC	p.F543F	PDLIM5_ENST00000437932.1_Silent_p.F434F|PDLIM5_ENST00000380176.3_3'UTR|PDLIM5_ENST00000542407.1_Silent_p.F421F|PDLIM5_ENST00000514743.1_Silent_p.F572F	NM_001256428.1|NM_006457.4	NP_001243357.1|NP_006448.4	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5	543	LIM zinc-binding 3.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		GATGTGAATTTCCCATAGAAG	0.388000													43	23					0	0	0.870114	0	0
LARP4B	23185	broad.mit.edu	37	10	859098	859098	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr10:859098G>A	ENST00000316157.3	-	17	2025	c.1985C>T	c.(1984-1986)cCt>cTt	p.P662L		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	662							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						TGGGGAAGAAGGAGGCTCTTT	0.498000													16	5					0	0	0.520397	0	0
CSF2RB	1439	broad.mit.edu	37	22	37319396	37319396	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr22:37319396C>T	ENST00000262825.5	+	3	404	c.187C>T	c.(187-189)Cgc>Tgc	p.R63C	CSF2RB_ENST00000403662.3_Missense_Mutation_p.R63C|CSF2RB_ENST00000406230.1_Missense_Mutation_p.R63C	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	63					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	GACCCTCATTCGCCGGGTGAA	0.652000													8	16					0	0	0.307466	0	0
CDH4	1002	broad.mit.edu	37	20	60348129	60348129	+	Missense_Mutation	SNP	C	C	T	rs145462500		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:60348129C>T	ENST00000360469.5	+	4	555	c.467C>T	c.(466-468)cCc>cTc	p.P156L	CDH4_ENST00000543233.1_Missense_Mutation_p.P82L	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	156					adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CTGCCGTGGCCCCAGCACCAG	0.652000													8	10					0	0	0.335167	0	0
SMARCA2	6595	broad.mit.edu	37	9	2181573	2181573	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:2181573C>T	ENST00000382203.1	+	30	4465	c.4256C>T	c.(4255-4257)tCa>tTa	p.S1419L	SMARCA2_ENST00000324954.5_Missense_Mutation_p.S65L|SMARCA2_ENST00000357248.2_Missense_Mutation_p.S1401L|SMARCA2_ENST00000302401.3_Missense_Mutation_p.S107L|SMARCA2_ENST00000382194.1_Missense_Mutation_p.S1401L|SMARCA2_ENST00000382186.1_Missense_Mutation_p.S83L|SMARCA2_ENST00000349721.2_Missense_Mutation_p.S1419L|SMARCA2_ENST00000382185.1_Missense_Mutation_p.S65L			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1419	Bromo.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		TCCTACAGTTCAGGGCGACAG	0.333000													20	9					0	0	0.624587	0	0
DUOX2	50506	broad.mit.edu	37	15	45398521	45398521	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:45398521C>T	ENST00000389039.6	-	17	2335	c.1950G>A	c.(1948-1950)atG>atA	p.M650I	DUOX2_ENST00000603300.1_Missense_Mutation_p.M650I			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	650					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CTGGCCACTCCATCGCTGGGG	0.592000													15	37					0	0	0.539581	0	0
TICRR	90381	broad.mit.edu	37	15	90119080	90119080	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:90119080C>T	ENST00000268138.7	+	1	368	c.263C>T	c.(262-264)gCc>gTc	p.A88V	TICRR_ENST00000560985.1_Missense_Mutation_p.A88V|RP11-429B14.1_ENST00000559041.1_RNA					TOPBP1-interacting checkpoint and replication regulator																		GAGGATCGCGCCCACCTGCCC	0.731000													6	5					0	0	0.307466	0	0
IFNA14	3448	broad.mit.edu	37	9	21239422	21239422	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:21239422G>A	ENST00000380222.2	-	1	556	c.513C>T	c.(511-513)atC>atT	p.I171I		NM_002172.2	NP_002163.2	P01570	IFN14_HUMAN	interferon, alpha 14	171					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)	11				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GGGATCTCATGATTTCTGCTC	0.393000													156	101					0	0	0.870114	0	0
SLC25A47	283600	broad.mit.edu	37	14	100795125	100795125	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:100795125G>A	ENST00000361529.3	+	5	468	c.390G>A	c.(388-390)caG>caA	p.Q130Q	SLC25A47_ENST00000557052.1_5'UTR	NM_207117.2	NP_997000.2	Q6Q0C1	S2547_HUMAN	solute carrier family 25, member 47	130					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	13						CACAGGCGCAGAAGCAGCAGC	0.677000													20	5					0	0	0.624587	0	0
CGNL1	84952	broad.mit.edu	37	15	57730212	57730212	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:57730212C>T	ENST00000281282.5	+	2	93	c.15C>T	c.(13-15)ttC>ttT	p.F5F		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	5	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGCTGTATTTCGGTGAATATC	0.438000													148	167					0	0	0.870114	0	0
BRPF3	27154	broad.mit.edu	37	6	36177996	36177996	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:36177996C>T	ENST00000357641.6	+	6	2123	c.1870C>T	c.(1870-1872)Cca>Tca	p.P624S	BRPF3_ENST00000339717.7_Missense_Mutation_p.P624S|BRPF3_ENST00000543502.1_Missense_Mutation_p.P624S|BRPF3_ENST00000534694.1_Missense_Mutation_p.P624S|BRPF3_ENST00000443324.2_Missense_Mutation_p.P624S|BRPF3_ENST00000534400.1_Missense_Mutation_p.P624S	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	624	Bromo.				histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						TGTTTAGGTTCCAGATTACCT	0.438000													8	13					0	0	0.361761	0	0
GLTPD1	80772	broad.mit.edu	37	1	1262675	1262675	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:1262675C>T	ENST00000343938.4	+	3	588	c.177C>T	c.(175-177)tcC>tcT	p.S59S	GLTPD1_ENST00000464957.1_3'UTR	NM_001029885.1	NP_001025056.1	Q5TA50	GLTD1_HUMAN	glycolipid transfer protein domain containing 1	59						cytoplasm	glycolipid binding|glycolipid transporter activity			lung(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		ACGTGGTCTCCAAGCTGCGGA	0.662000													20	7					0	0	0.667858	0	0
GPATCH2	55105	broad.mit.edu	37	1	217665071	217665071	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:217665071G>A	ENST00000366935.3	-	8	1338	c.1228C>T	c.(1228-1230)Cga>Tga	p.R410*	GPATCH2_ENST00000489246.2_5'UTR	NM_018040.2	NP_060510.1	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	410						intracellular	nucleic acid binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)	35				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		CTTTCAGCTCGATTATCTCTC	0.313000													50	23					0	0	0.870114	0	0
TSGA13	114960	broad.mit.edu	37	7	130364146	130364146	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:130364146C>T	ENST00000456951.1	-	6	1085	c.234G>A	c.(232-234)agG>agA	p.R78R	TSGA13_ENST00000356588.3_Silent_p.R78R			Q96PP4	TSG13_HUMAN	testis specific, 13	78										endometrium(1)|kidney(3)|large_intestine(3)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	18	Melanoma(18;0.0435)					TGGTGTTTTTCCTGTTTTGAG	0.448000													14	10					0	0	0.457914	0	0
SPAG17	200162	broad.mit.edu	37	1	118598459	118598459	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:118598459C>T	ENST00000336338.5	-	19	2684	c.2619G>A	c.(2617-2619)atG>atA	p.M873I		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	873						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTTTCTCATTCATTTTAGATT	0.328000													29	10					0	0	0.706142	0	0
KCNK15	60598	broad.mit.edu	37	20	43374695	43374695	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:43374695C>T	ENST00000372861.3	+	1	275	c.144C>T	c.(142-144)ctC>ctT	p.L48L		NM_022358.3	NP_071753.2	Q9H427	KCNKF_HUMAN	potassium channel, subfamily K, member 15	48						integral to membrane	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(115;0.0122)				GGGGCGCTCTCCGGAGGAAGT	0.711000													3	5					0	0	0.115264	0	0
POTEE	445582	broad.mit.edu	37	2	132021858	132021858	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:132021858G>A	ENST00000356920.5	+	15	2924	c.2830G>A	c.(2830-2832)Gat>Aat	p.D944N	PLEKHB2_ENST00000404460.1_Intron|POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000303908.3_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	944	Actin-like.						ATP binding										CGAGCTGCCCGATGGCCAGGT	0.602000													10	118					0	0	0.435327	0	0
PREX2	80243	broad.mit.edu	37	8	69069587	69069587	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:69069587G>A	ENST00000288368.4	+	35	4539	c.4262G>A	c.(4261-4263)aGa>aAa	p.R1421K		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1421					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TATTATTACAGAGACAATGTT	0.353000													14	51					0	0	0.500413	0	0
DNM3	26052	broad.mit.edu	37	1	171890926	171890926	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:171890926G>A	ENST00000358155.4	+	2	376	c.200G>A	c.(199-201)cGa>cAa	p.R67Q	DNM3_ENST00000367733.2_Missense_Mutation_p.R67Q|DNM3_ENST00000367731.1_Missense_Mutation_p.R67Q|DNM3_ENST00000355305.5_Missense_Mutation_p.R67Q|DNM3_ENST00000520906.1_Missense_Mutation_p.R67Q	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	67					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						GTAACAAGACGACCTCTTGTG	0.433000													10	3					0	0	0.361761	0	0
ABCA6	23460	broad.mit.edu	37	17	67129868	67129868	+	Silent	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:67129868T>C	ENST00000284425.2	-	6	879	c.705A>G	c.(703-705)gtA>gtG	p.V235V		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	235					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					ATATAAAATATACAAGTGGGG	0.303000													10	20					0	0	0.361761	0	0
IGHG3	3502	broad.mit.edu	37	14	106236039	106236039	+	RNA	SNP	T	T	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:106236039T>A	ENST00000390551.2	-	0	764																											GGGAGGGCTTTGTTGGAGACC	0.597000													156	78					0	0	0.870114	0	0
LRRC1	55227	broad.mit.edu	37	6	53778708	53778708	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:53778708G>A	ENST00000370888.1	+	11	1324	c.1047G>A	c.(1045-1047)cgG>cgA	p.R349R		NM_018214.4	NP_060684.4	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	349						cytoplasm|membrane				cervix(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		GACTAACTCGGATACCTGCAG	0.468000													18	46					0	0	0.557998	0	0
OR11L1	391189	broad.mit.edu	37	1	248004808	248004808	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:248004808G>A	ENST00000355784.2	-	1	446	c.391C>T	c.(391-393)Cgc>Tgc	p.R131C		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	131					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R131S(1)		NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AAGGGGTAGCGGAGTGGGCTG	0.587000													26	3					0	0	0.693898	0	0
C5	727	broad.mit.edu	37	9	123779744	123779744	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:123779744C>T	ENST00000223642.1	-	14	1791	c.1762G>A	c.(1762-1764)Gtg>Atg	p.V588M		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	588					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TTAAGAGACACAGTTTGGCCT	0.423000													21	10					0	0	0.654019	0	0
CNTN2	6900	broad.mit.edu	37	1	205041148	205041148	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:205041148C>T	ENST00000331830.4	+	20	2902	c.2618C>T	c.(2617-2619)gCc>gTc	p.A873V		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	873	Fibronectin type-III 3.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GACACCAGTGCCCGAGTCAGC	0.647000													35	11					0	0	0.840704	0	0
ARMC5	79798	broad.mit.edu	37	16	31477519	31477519	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:31477519C>T	ENST00000408912.3	+	8	2719	c.2402C>T	c.(2401-2403)tCc>tTc	p.S801F	ARMC5_ENST00000412665.2_Missense_Mutation_p.S350F|ARMC5_ENST00000268314.4_Missense_Mutation_p.S706F|ARMC5_ENST00000563544.1_Missense_Mutation_p.S706F|ARMC5_ENST00000538189.1_Missense_Mutation_p.S738F|ARMC5_ENST00000457010.2_3'UTR			Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	706	BTB.						binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						GACTCCCTTTCCTGCCTCCAA	0.647000													16	16					0	0	0.608945	0	0
TFB1M	51106	broad.mit.edu	37	6	155578999	155578999	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:155578999C>T	ENST00000367166.4	-	7	1067	c.1012G>A	c.(1012-1014)Gag>Aag	p.E338K		NM_016020.3	NP_057104.2	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		GCGTCATCCTCTTCTTTTTCT	0.418000													5	8					0	0	0.184627	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458398	45458398	+	RNA	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:45458398C>T	ENST00000548424.1	+	0	448																											TACCTGTTTTCCTTTGGCTCC	0.522000													8	15					0	0	0.387290	0	0
ELN	2006	broad.mit.edu	37	7	73481102	73481102	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:73481102C>T	ENST00000252034.7	+	32	2526	c.2127C>T	c.(2125-2127)ttC>ttT	p.F709F	ELN_ENST00000380575.4_Silent_p.F662F|ELN_ENST00000358929.4_Silent_p.F777F|ELN_ENST00000458204.1_Silent_p.F699F|ELN_ENST00000429192.1_Silent_p.F677F|ELN_ENST00000357036.5_Silent_p.F696F|ELN_ENST00000380584.4_Silent_p.F643F|ELN_ENST00000320399.6_Silent_p.F742F|ELN_ENST00000414324.1_Silent_p.F685F|ELN_ENST00000380562.4_Silent_p.F715F|ELN_ENST00000380553.4_Silent_p.F555F|ELN_ENST00000380576.5_Silent_p.F690F|ELN_ENST00000320492.7_Silent_p.F628F|ELN_ENST00000445912.1_Silent_p.F691F	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	771	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CTCCCATTTTCCCAGGTATGC	0.612000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						12	40					0	0	0.435327	0	0
KCNF1	3754	broad.mit.edu	37	2	11052970	11052970	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:11052970G>A	ENST00000295082.1	+	1	908	c.418G>A	c.(418-420)Gag>Aag	p.E140K		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	140						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		GGAGCTGGAGGAGATCGCGCG	0.632000													19	27					0	0	0.654019	0	0
MROH2B	133558	broad.mit.edu	37	5	41005705	41005705	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:41005705C>T	ENST00000399564.4	-	35	4242	c.3792G>A	c.(3790-3792)atG>atA	p.M1264I	MROH2B_ENST00000506092.2_Missense_Mutation_p.M819I	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GCAGCTGTTCCATGATGTCCA	0.483000													15	11					0	0	0.575678	0	0
KPRP	448834	broad.mit.edu	37	1	152732493	152732493	+	Silent	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:152732493T>C	ENST00000368773.1	+	2	487	c.429T>C	c.(427-429)acT>acC	p.T143T	KPRP_ENST00000606109.1_Silent_p.T143T	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	143	Gln-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATACAGAAACTTGTTATGTAG	0.512000													108	29					0	0	0.870114	0	0
NEFM	4741	broad.mit.edu	37	8	24771739	24771739	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:24771739C>T	ENST00000221166.5	+	1	1215	c.433C>T	c.(433-435)Cag>Tag	p.Q145*	GS1-72M22.1_ENST00000607058.1_RNA|NEFM_ENST00000521540.1_3'UTR|NEFM_ENST00000518131.1_Nonsense_Mutation_p.Q145*|NEFM_ENST00000437366.2_Nonsense_Mutation_p.Q145*			P07197	NFM_HUMAN	neurofilament, medium polypeptide	145	Linker 1.|Rod.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CTCGCACGCCCAGCTGGGCGA	0.632000													5	4					0	0	0.184627	0	0
MUC16	94025	broad.mit.edu	37	19	9069660	9069660	+	Missense_Mutation	SNP	G	G	A	rs74872724	byFrequency	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:9069660G>A	ENST00000397910.4	-	3	17989	c.17786C>T	c.(17785-17787)tCc>tTc	p.S5929F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5931	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGCACTGGGGAAGAAGGAGA	0.498000													21	14					0	0	0.667858	0	0
ATRX	546	broad.mit.edu	37	X	76939747	76939747	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:76939747G>A	ENST00000373344.5	-	9	1215	c.1001C>T	c.(1000-1002)tCc>tTc	p.S334F	ATRX_ENST00000395603.3_Missense_Mutation_p.S296F|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	334					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	GCCAGAACAGGAATCATCTAA	0.358000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						7	6					0	0	0.248553	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86526897	86526897	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:86526897C>T	ENST00000450689.2	-	19	2795	c.2610G>A	c.(2608-2610)gaG>gaA	p.E870E	KIAA1324L_ENST00000297222.6_Silent_p.E630E|KIAA1324L_ENST00000444627.1_Silent_p.E799E|KIAA1324L_ENST00000416314.1_Silent_p.E703E	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	870						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					CTTCAGCACTCTCCCACAGGA	0.463000													20	27					0	0	0.608945	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766897	77766897	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:77766897G>A	ENST00000521891.2	+	10	8188	c.7740G>A	c.(7738-7740)agG>agA	p.R2580R	ZFHX4_ENST00000518282.1_Silent_p.R2554R|ZFHX4_ENST00000455469.2_Silent_p.R2535R|ZFHX4_ENST00000050961.6_Silent_p.R2535R	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2535						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCCTAAAAAGGAAACTAGACG	0.502000										HNSCC(33;0.089)			5	20					0	0	0.217242	0	0
NEURL4	84461	broad.mit.edu	37	17	7227009	7227009	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:7227009G>A	ENST00000399464.2	-	13	2310	c.2295C>T	c.(2293-2295)gtC>gtT	p.V765V	NEURL4_ENST00000315614.7_Silent_p.V765V|NEURL4_ENST00000570460.1_Silent_p.V743V	NM_032442.2	NP_115818.2			neuralized E3 ubiquitin protein ligase 4											central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCTTCTGAATGACAATTTCAA	0.602000													10	6					0	0	0.387290	0	0
C2orf71	388939	broad.mit.edu	37	2	29294105	29294105	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:29294105C>T	ENST00000331664.5	-	1	3022	c.3023G>A	c.(3022-3024)aGg>aAg	p.R1008K		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	1008					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						GCTCCGGCGCCTCTTGTCTGC	0.662000													11	25					0	0	0.411799	0	0
HLCS	3141	broad.mit.edu	37	21	38302641	38302641	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr21:38302641G>A	ENST00000399120.1	-	6	2319	c.1089C>T	c.(1087-1089)gtC>gtT	p.V363V	HLCS_ENST00000482273.1_5'UTR|HLCS_ENST00000336648.3_Silent_p.V363V	NM_001242784.1	NP_001229713.1	P50747	BPL1_HUMAN	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	363			V -> D (in HLCS deficiency; has normal or low KM values for biotin (non-KM mutant)).		cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	TCTCTCTAAGGACTTCGTATC	0.458000													11	25					0	0	0.361761	0	0
KSR2	283455	broad.mit.edu	37	12	117962701	117962701	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:117962701G>A	ENST00000425217.1	-	14	2142	c.2088C>T	c.(2086-2088)ttC>ttT	p.F696F	KSR2_ENST00000339824.5_Silent_p.F725F|KSR2_ENST00000302438.5_Silent_p.F422F|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	725	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGGCACCCATGAAAAGCACCA	0.577000													8	16					0	0	0.335167	0	0
TMEM5	10329	broad.mit.edu	37	12	64174929	64174929	+	Silent	SNP	A	A	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:64174929A>T	ENST00000261234.6	+	2	458	c.300A>T	c.(298-300)gtA>gtT	p.V100V	TMEM5_ENST00000537373.1_5'UTR|RP11-415I12.3_ENST00000509615.2_RNA|TMEM5_ENST00000537982.1_3'UTR	NM_014254.1	NP_055069.1	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	100						integral to plasma membrane				breast(1)|large_intestine(3)|liver(2)|lung(7)|prostate(1)|skin(1)	15		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		ATCTCAGTGTACAAATCTGGG	0.313000													40	54					0	0	0.870114	0	0
SUGP2	10147	broad.mit.edu	37	19	19120956	19120956	+	Silent	SNP	G	G	A	rs139001412		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:19120956G>A	ENST00000601879.1	-	5	2343	c.2046C>T	c.(2044-2046)ctC>ctT	p.L682L	SUGP2_ENST00000456085.2_Silent_p.L451L|SUGP2_ENST00000337018.6_Silent_p.L682L|SUGP2_ENST00000452918.2_Silent_p.L682L|SUGP2_ENST00000600377.1_Silent_p.L696L			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	682					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						GAGCACGGAGGAGCCCCCGCC	0.662000													10	54					0	0	0.361761	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100537692	100537692	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:100537692G>A	ENST00000268070.4	-	19	2799	c.2694C>T	c.(2692-2694)gtC>gtT	p.V898V		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	898	TSP type-1 3.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		GCCGCGTAGCGACGTGTGTGC	0.692000													5	11					0	0	0.278610	0	0
ELTD1	64123	broad.mit.edu	37	1	79403674	79403674	+	Splice_Site	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:79403674T>C	ENST00000370742.3	-	6	641	c.576_splice	c.e6-1	p.E193_splice		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	193					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TTTTACAAATTCCTATTGAAA	0.299000													12	4					0	0	0.457914	0	0
POLR2A	5430	broad.mit.edu	37	17	7417414	7417414	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:7417414C>T	ENST00000322644.6	+	29	6230	c.5831C>T	c.(5830-5832)tCc>tTc	p.S1944F		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	1944	52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				TCTCCCACTTCCCCTGGTTAC	0.637000													28	32					0	0	0.812448	0	0
TTC13	79573	broad.mit.edu	37	1	231044697	231044697	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:231044697G>A	ENST00000366661.4	-	21	2386	c.2379C>T	c.(2377-2379)ccC>ccT	p.P793P	TTC13_ENST00000414259.1_Silent_p.P740P|TTC13_ENST00000366662.4_Silent_p.P739P	NM_024525.4	NP_078801.3	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13	793							binding			central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	39	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		CCTTCCCTTTGGGAATTTTTC	0.383000													125	25					0	0	0.870114	0	0
PAK7	57144	broad.mit.edu	37	20	9525015	9525015	+	Splice_Site	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:9525015C>T	ENST00000378429.3	-	9	2416		c.e9+1		PAK7_ENST00000353224.5_Splice_Site|PAK7_ENST00000378423.1_Splice_Site	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7								ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			GACCCCCTTACCTCTGTCCCA	0.542000													82	79					0	0	0.870114	0	0
DNAH8	1769	broad.mit.edu	37	6	38813380	38813380	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:38813380G>A	ENST00000359357.3	+	34	4479	c.4225G>A	c.(4225-4227)Gat>Aat	p.D1409N	DNAH8_ENST00000441566.1_Missense_Mutation_p.D1409N|DNAH8_ENST00000449981.2_Missense_Mutation_p.D1626N					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TAAGGAGAAGGATATCGAAGC	0.383000													13	42					0	0	0.557998	0	0
MUC16	94025	broad.mit.edu	37	19	9089550	9089550	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:9089550C>T	ENST00000397910.4	-	1	2468	c.2265G>A	c.(2263-2265)ggG>ggA	p.G755G		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	755	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTCAGGAGTCCCTGTGGTAA	0.473000													51	41					0	0	0.870114	0	0
TMEM132D	121256	broad.mit.edu	37	12	130184678	130184678	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:130184678G>A	ENST00000422113.2	-	2	971	c.645C>T	c.(643-645)tcC>tcT	p.S215S		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	215						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GCTGGTCCACGGACTTCCTCC	0.692000													11	31					0	0	0.435327	0	0
PLCXD3	345557	broad.mit.edu	37	5	41510611	41510611	+	Silent	SNP	C	C	T	rs150477234	by1000genomes	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:41510611C>T	ENST00000377801.3	-	1	92	c.18G>A	c.(16-18)ggG>ggA	p.G6G	PLCXD3_ENST00000328457.3_Silent_p.G6G			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	6					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						GCTCGTTTTTCCCCTGAGACG	0.617000													16	7					0	0	0.539581	0	0
SLC9C1	285335	broad.mit.edu	37	3	111936300	111936300	+	Silent	SNP	C	C	T	rs139599943		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:111936300C>T	ENST00000305815.5	-	15	2031	c.1779G>A	c.(1777-1779)gaG>gaA	p.E593E	SLC9C1_ENST00000487372.1_Silent_p.E545E	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	593					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										TTGATGGGCCCTCTTTTTCCT	0.299000													17	30					0	0	0.639603	0	0
PTX4	390667	broad.mit.edu	37	16	1536507	1536507	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:1536507G>A	ENST00000440447.2	-	3	496	c.425C>T	c.(424-426)tCg>tTg	p.S142L	PTX4_ENST00000293922.1_Silent_p.F285F|PTX4_ENST00000447419.2_Silent_p.F290F			Q96A99	PTX4_HUMAN	pentraxin 4, long	0						extracellular region	metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17						GGGCAGTGACGAAACCAGGGC	0.642000													21	8					0	0	0.639603	0	0
SPTBN4	57731	broad.mit.edu	37	19	41007858	41007858	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:41007858C>T	ENST00000352632.3	+	8	901	c.815C>T	c.(814-816)tCc>tTc	p.S272F	SPTBN4_ENST00000598249.1_Missense_Mutation_p.S272F|SPTBN4_ENST00000595535.1_Missense_Mutation_p.S272F|SPTBN4_ENST00000344104.3_Missense_Mutation_p.S272F|SPTBN4_ENST00000338932.3_Missense_Mutation_p.S272F			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	272	Actin-binding.|CH 2.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GATGAGAAGTCCATCATCACC	0.507000													20	116					0	0	0.693898	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72658179	72658179	+	RNA	SNP	T	T	C	rs147293416	by1000genomes	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:72658179T>C	ENST00000425256.1	-	0	1732					NR_002164.1																						cagagtgatttcggatgaatt	0.507000													3	70					0	0	0.115264	0	0
UBAP2L	9898	broad.mit.edu	37	1	154229841	154229841	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:154229841C>T	ENST00000428931.1	+	20	2540	c.2373C>T	c.(2371-2373)ctC>ctT	p.L791L	UBAP2L_ENST00000343815.6_Silent_p.L791L|UBAP2L_ENST00000271877.7_Silent_p.L802L|UBAP2L_ENST00000361546.2_Silent_p.L791L	NM_014847.3	NP_055662.3	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like	791					binding of sperm to zona pellucida		protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|prostate(1)|urinary_tract(2)	50	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTCCCAACCTCCCTCCTGGGG	0.468000													29	13					0	0	0.819951	0	0
PRR25	388199	broad.mit.edu	37	16	863791	863791	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:863791C>G	ENST00000301698.1	+	3	1139	c.1139C>G	c.(1138-1140)cCg>cGg	p.P380R		NM_001013638.1	NP_001013660.1	Q96S07	PRR25_HUMAN	proline rich 25	380										large_intestine(1)|lung(1)|skin(1)	3						CGGTTCGGGCCGCGCTCCTGC	0.786000													6	1					0	0	0.278610	0	0
ACACB	32	broad.mit.edu	37	12	109692078	109692078	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:109692078A>T	ENST00000338432.7	+	44	6224	c.6105A>T	c.(6103-6105)gaA>gaT	p.E2035D	ACACB_ENST00000377854.5_Missense_Mutation_p.E1965D|ACACB_ENST00000543201.1_Missense_Mutation_p.E701D|ACACB_ENST00000377848.3_Missense_Mutation_p.E2035D			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	2035	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	GAGAAATTGAATTCCTCCCAT	0.502000													37	93					0	0	0.840704	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47219493	47219493	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:47219493G>A	ENST00000300404.2	+	3	551	c.492G>A	c.(490-492)gtG>gtA	p.V164V	B4GALNT2_ENST00000504681.1_Silent_p.V78V|B4GALNT2_ENST00000393354.2_Silent_p.V104V	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	164					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			TCCCAGCGGTGAAAGCGAGGA	0.512000													22	83					0	0	0.681144	0	0
TLR5	7100	broad.mit.edu	37	1	223283825	223283825	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:223283825G>A	ENST00000540964.1	-	4	3010	c.2549C>T	c.(2548-2550)cCg>cTg	p.P850L	TLR5_ENST00000342210.6_Missense_Mutation_p.P850L			O60602	TLR5_HUMAN	toll-like receptor 5	850			Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		AGTTTGCAACGGAATGTTATT	0.373000													39	18					0	0	0.870114	0	0
CLPB	81570	broad.mit.edu	37	11	72004437	72004437	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:72004437G>C	ENST00000294053.3	-	17	2271	c.2098C>G	c.(2098-2100)Cct>Gct	p.P700A	CLPB_ENST00000340729.5_Missense_Mutation_p.P641A|CLPB_ENST00000437826.2_Missense_Mutation_p.P655A|CLPB_ENST00000538021.1_Missense_Mutation_p.P308A|CLPB_ENST00000538039.1_Missense_Mutation_p.P670A|CLPB_ENST00000543042.1_Missense_Mutation_p.P499A	NM_001258394.1|NM_030813.4	NP_001245323.1|NP_110440.1	Q9H078	CLPB_HUMAN	ClpB caseinolytic peptidase B homolog (E. coli)	700					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	19						ACCTTCTCAGGGTGCAGTGGT	0.592000													28	16					0	0	0.740014	0	0
ZNF281	23528	broad.mit.edu	37	1	200376691	200376691	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:200376691G>A	ENST00000294740.2	-	2	2267	c.2143C>T	c.(2143-2145)Cct>Tct	p.P715S	ZNF281_ENST00000367353.1_Missense_Mutation_p.P715S|ZNF281_ENST00000367352.3_Missense_Mutation_p.P679S	NM_012482.3	NP_036614.1	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	715					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	27						CACTCCAAAGGAGACGTAGTG	0.433000													62	11					0	0	0.870114	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21036398	21036398	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:21036398G>A	ENST00000381545.3	+	13	1763	c.1544G>A	c.(1543-1545)aGa>aAa	p.R515K	LST3_ENST00000540229.1_Missense_Mutation_p.R515K|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.R515K|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.R515K	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	515					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					CTCCAGAACAGAAATTACTCA	0.333000													30	33					0	0	0.804634	0	0
CYP4X1	260293	broad.mit.edu	37	1	47512182	47512182	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:47512182G>A	ENST00000371901.3	+	9	1367	c.1117G>A	c.(1117-1119)Gag>Aag	p.E373K	CYP4X1_ENST00000538609.1_Missense_Mutation_p.E372K	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	373						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						GTGCATCAAGGAGACGTGCCG	0.493000													35	17					0	0	0.859065	0	0
COL6A3	1293	broad.mit.edu	37	2	238271994	238271994	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:238271994C>T	ENST00000295550.4	-	14	6417	c.5965G>A	c.(5965-5967)Gag>Aag	p.E1989K	COL6A3_ENST00000353578.4_Missense_Mutation_p.E1783K|COL6A3_ENST00000347401.3_Missense_Mutation_p.E1788K|COL6A3_ENST00000409809.1_Missense_Mutation_p.E1783K|COL6A3_ENST00000346358.4_Missense_Mutation_p.E1789K|COL6A3_ENST00000472056.1_Missense_Mutation_p.E1382K	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1989	Nonhelical region.|VWFA 10.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ATTAGCCGCTCCAAGTTGACC	0.498000													25	24					0	0	0.681144	0	0
SAMD7	344658	broad.mit.edu	37	3	169639031	169639031	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:169639031C>T	ENST00000428432.2	+	4	505	c.116C>T	c.(115-117)aCt>aTt	p.T39I	SAMD7_ENST00000335556.3_Missense_Mutation_p.T39I	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	39										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GTAGCTCCAACTGACCCAAGA	0.413000													58	89					0	0	0.870114	0	0
RSAD1	55316	broad.mit.edu	37	17	48557289	48557289	+	Silent	SNP	C	C	T	rs11555806		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:48557289C>T	ENST00000258955.2	+	3	403	c.318C>T	c.(316-318)ccC>ccT	p.P106P		NM_018346.1	NP_060816.1	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing 1	106					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			TAGCCAGTCCCCACACGGTGG	0.607000											OREG0024566	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	43					0	0	0.457914	0	0
ULK4	54986	broad.mit.edu	37	3	41961249	41961249	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:41961249G>A	ENST00000301831.4	-	6	1065	c.603C>T	c.(601-603)gaC>gaT	p.D201D	ULK4_ENST00000420927.1_Silent_p.D201D	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	201	Protein kinase.						ATP binding|protein serine/threonine kinase activity	p.D201E(2)		breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AAGACCAGAGGTCACTGGAGA	0.413000													56	113					0	0	0.870114	0	0
KRT6C	286887	broad.mit.edu	37	12	52867474	52867474	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:52867474C>T	ENST00000252250.6	-	1	95	c.48G>A	c.(46-48)cgG>cgA	p.R16R		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	16	Head.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		CACTGAAACCCCGGCGGCTGC	0.667000													7	22					0	0	0.307466	0	0
ZNF527	84503	broad.mit.edu	37	19	37879562	37879562	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:37879562C>T	ENST00000436120.2	+	5	718	c.611C>T	c.(610-612)tCa>tTa	p.S204L	ZNF527_ENST00000587349.1_Intron	NM_032453.1	NP_115829.1	Q8NB42	ZN527_HUMAN	zinc finger protein 527	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	33			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCCCAAAATTCAGTCATAATT	0.323000													7	31					0	0	0.307466	0	0
ITFG1	81533	broad.mit.edu	37	16	47292640	47292640	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:47292640G>A	ENST00000320640.6	-	12	1461	c.1233C>T	c.(1231-1233)gaC>gaT	p.D411D	ITFG1_ENST00000568047.1_5'UTR|ITFG1_ENST00000544001.2_Silent_p.D298D	NM_030790.3	NP_110417.2	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	411						extracellular region|integral to membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	19		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				GCACTACAATGTCCAAGATTC	0.284000													11	8					0	0	0.411799	0	0
IGSF1	3547	broad.mit.edu	37	X	130409260	130409260	+	Splice_Site	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:130409260C>T	ENST00000370904.1	-	23	4068	c.3157_splice	c.e23-1	p.G1053_splice	IGSF1_ENST00000370903.3_Splice_Site_p.G1067_splice|IGSF1_ENST00000370910.1_Splice_Site_p.G1053_splice|IGSF1_ENST00000361420.3_Splice_Site_p.G1062_splice			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	1062	Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						GGGGAGTAAGCCTGGAAGAAA	0.522000													7	45					0	0	0.248553	0	0
C10orf71	118461	broad.mit.edu	37	10	50531758	50531758	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr10:50531758G>A	ENST00000374144.3	+	3	1456	c.1168G>A	c.(1168-1170)Ggg>Agg	p.G390R	C10orf71_ENST00000323868.4_Missense_Mutation_p.G390R			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	390								p.G390R(1)		endometrium(1)	1						TGGCAAAAAAGGGAAAGAAAG	0.473000													22	9					0	0	0.608945	0	0
KCNK15	60598	broad.mit.edu	37	20	43374696	43374696	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:43374696C>T	ENST00000372861.3	+	1	276	c.145C>T	c.(145-147)Cgg>Tgg	p.R49W		NM_022358.3	NP_071753.2	Q9H427	KCNKF_HUMAN	potassium channel, subfamily K, member 15	49						integral to membrane	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(115;0.0122)				GGGCGCTCTCCGGAGGAAGTT	0.711000													3	5					0	0	0.115264	0	0
UGGT2	55757	broad.mit.edu	37	13	96665626	96665626	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr13:96665626G>A	ENST00000376747.3	-	5	665	c.595C>T	c.(595-597)Cac>Tac	p.H199Y	UGGT2_ENST00000376714.3_Missense_Mutation_p.H199Y|UGGT2_ENST00000397618.3_Missense_Mutation_p.H199Y|UGGT2_ENST00000467305.1_5'UTR|UGGT2_ENST00000376712.4_Missense_Mutation_p.H199Y	NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	199					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						AATACTTTGTGAAATGCACTA	0.353000													27	11					0	0	0.779181	0	0
MGA	23269	broad.mit.edu	37	15	42034889	42034889	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:42034889C>T	ENST00000219905.7	+	15	4912	c.4731C>T	c.(4729-4731)gtC>gtT	p.V1577V	MGA_ENST00000389936.4_Silent_p.V1577V|MGA_ENST00000566586.1_Intron|MGA_ENST00000545763.1_Intron|MGA_ENST00000570161.1_Silent_p.V1577V	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1577						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CAGTAATGGTCGTCACACCTG	0.498000													15	13					0	0	0.500413	0	0
CUX2	23316	broad.mit.edu	37	12	111785825	111785825	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:111785825C>T	ENST00000261726.6	+	22	4311	c.4157C>T	c.(4156-4158)tCc>tTc	p.S1386F		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1386	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						GCCTCAGAGTCCTCACGCTGC	0.612000													14	40					0	0	0.500413	0	0
TEKT4P2	100132288	broad.mit.edu	37	21	9907319	9907319	+	RNA	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr21:9907319G>A	ENST00000416067.1	-	0	1473					NR_037872.1|NR_038327.1																						GGCGGTCGATGAAGAGACTGT	0.592000													13	24					0	0	0.500413	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4442750	4442750	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:4442750G>A	ENST00000254718.4	-	26	4253	c.3947C>T	c.(3946-3948)gCc>gTc	p.A1316V	MYBBP1A_ENST00000381556.2_Missense_Mutation_p.A1316V			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a	1316	Required for nuclear and nucleolar localization (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)	24						TTTCTTCTTGGCCCCACTCTG	0.577000													69	59					0	0	0.870114	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554380	140554380	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:140554380C>T	ENST00000231137.3	+	1	2138	c.1964C>T	c.(1963-1965)aCc>aTc	p.T655I		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		655	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCTCGGCCACCGCCACGCTG	0.711000													33	194					0	0	0.827153	0	0
PON1	5444	broad.mit.edu	37	7	94944801	94944801	+	Splice_Site	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:94944801C>T	ENST00000222381.3	-	4	434	c.201_splice	c.e4-1	p.G68_splice	PON1_ENST00000542556.1_Splice_Site_p.G68_splice	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	68					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	ATACTTTAATCCCTTATAAAC	0.428000													21	34					0	0	0.624587	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18715752	18715752	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:18715752G>A	ENST00000433979.1	+	26	3699	c.3583G>A	c.(3583-3585)Gaa>Aaa	p.E1195K	PIK3C2G_ENST00000538779.1_Missense_Mutation_p.E1236K|PIK3C2G_ENST00000266497.5_Missense_Mutation_p.E1195K	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1195					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				TTTTCCTCAGGAATCCTGTTT	0.403000													3	1					0	0	0.115264	0	0
PSG7	5676	broad.mit.edu	37	19	43428920	43428920	+	RNA	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:43428920G>A	ENST00000406070.2	-	0	1396					NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				gctctttgaggttccatggga	0.418000													6	52					0	0	0.248553	0	0
FOXI1	2299	broad.mit.edu	37	5	169535120	169535120	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:169535120G>A	ENST00000306268.6	+	2	703	c.642G>A	c.(640-642)agG>agA	p.R214R	FOXI1_ENST00000449804.2_Intron			Q12951	FOXI1_HUMAN	forkhead box I1	214					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding	p.R214R(1)		breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATTTCCGCAGGAAAAGGAAGA	0.493000									Pendred syndrome				24	11					0	0	0.693898	0	0
FREM2	341640	broad.mit.edu	37	13	39433567	39433567	+	Silent	SNP	G	G	A	rs115054860	by1000genomes	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr13:39433567G>A	ENST00000280481.7	+	14	7575	c.7359G>A	c.(7357-7359)gtG>gtA	p.V2453V		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2453					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGAGAGAAGTGGACTTCGACA	0.537000													5	61					0	0	0.278610	0	0
LRP1B	53353	broad.mit.edu	37	2	141625352	141625352	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:141625352G>A	ENST00000389484.3	-	27	5357	c.4386C>T	c.(4384-4386)atC>atT	p.I1462I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1462					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GACCTCGGATGATTTCTATCA	0.408000										TSP Lung(27;0.18)			37	32					0	0	0.853193	0	0
IL6ST	3572	broad.mit.edu	37	5	55260006	55260006	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:55260006G>A	ENST00000381298.2	-	6	938	c.626C>T	c.(625-627)tCa>tTa	p.S209L	IL6ST_ENST00000381286.3_Intron|IL6ST_ENST00000381287.4_Missense_Mutation_p.S209L|IL6ST_ENST00000381294.3_Missense_Mutation_p.S209L|IL6ST_ENST00000336909.5_Missense_Mutation_p.S209L|IL6ST_ENST00000522633.2_Missense_Mutation_p.S209L|IL6ST_ENST00000381293.2_Intron|IL6ST_ENST00000536319.1_Missense_Mutation_p.S209L|IL6ST_ENST00000502326.3_Missense_Mutation_p.S209L	NM_001190981.1|NM_002184.3|NM_175767.2	NP_001177910.1|NP_002175.2|NP_786943.1	P40189	IL6RB_HUMAN	interleukin 6 signal transducer (gp130, oncostatin M receptor)	209	Fibronectin type-III 1.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			breast(2)|endometrium(5)|kidney(5)|large_intestine(4)|liver(2)|lung(1)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				GATATGATCTGATGTAACCTT	0.358000			O		hepatocellular ca								47	29					0	0	0.870114	0	0
ERBB2	2064	broad.mit.edu	37	17	37864760	37864760	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:37864760C>T	ENST00000406381.2	+	5	832	c.322C>T	c.(322-324)Cgg>Tgg	p.R108W	ERBB2_ENST00000269571.5_Missense_Mutation_p.R138W|ERBB2_ENST00000584450.1_Missense_Mutation_p.R138W|ERBB2_ENST00000578199.1_Missense_Mutation_p.R108W|ERBB2_ENST00000541774.1_Missense_Mutation_p.R123W|ERBB2_ENST00000584601.1_Missense_Mutation_p.R108W|ERBB2_ENST00000540042.1_Missense_Mutation_p.R108W|ERBB2_ENST00000540147.1_Missense_Mutation_p.R108W|ERBB2_ENST00000445658.2_Intron	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	138					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	AGGAGGCCTGCGGGAGCTGCA	0.592000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			15	28					0	0	0.539581	0	0
NLRP5	126206	broad.mit.edu	37	19	56515139	56515139	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:56515139C>T	ENST00000390649.3	+	2	120	c.120C>T	c.(118-120)ttC>ttT	p.F40F		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	40						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		ATCCACTTTTCCCCCAAAACC	0.438000													7	40					0	0	0.335167	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996047	140996047	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:140996047G>A	ENST00000285879.4	+	4	3143	c.2857G>A	c.(2857-2859)Gcc>Acc	p.A953T	MAGEC1_ENST00000406005.2_Missense_Mutation_p.A20T	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	953	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CTTCAGGAAAGCCCGTGAGTT	0.463000										HNSCC(15;0.026)			34	25					0	0	0.804634	0	0
TROAP	10024	broad.mit.edu	37	12	49717459	49717459	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:49717459C>T	ENST00000551245.1	+	2	179	c.68C>T	c.(67-69)cCg>cTg	p.P23L	RP11-161H23.9_ENST00000553259.1_RNA|TROAP_ENST00000550709.1_Missense_Mutation_p.P23L|TROAP_ENST00000257909.3_Missense_Mutation_p.P23L|TROAP_ENST00000549534.1_Missense_Mutation_p.P23L|TROAP_ENST00000549275.1_Missense_Mutation_p.P23L|TROAP_ENST00000548311.1_Missense_Mutation_p.P23L|TROAP_ENST00000380327.5_Missense_Mutation_p.P23L			Q12815	TROAP_HUMAN	trophinin associated protein	23					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						AGCAAGATTCCGGTACGCTCT	0.582000													78	103					0	0	0.870114	0	0
SLC41A3	54946	broad.mit.edu	37	3	125752456	125752456	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:125752456G>A	ENST00000383598.2	-	3	654	c.369C>T	c.(367-369)ctC>ctT	p.L123L	SLC41A3_ENST00000346785.5_Silent_p.L113L|SLC41A3_ENST00000514023.1_5'UTR|SLC41A3_ENST00000508835.1_Silent_p.L32L|SLC41A3_ENST00000360370.4_Silent_p.L149L|SLC41A3_ENST00000315891.6_Silent_p.L149L	NM_001008487.1	NP_001008487.1	Q96GZ6	S41A3_HUMAN	solute carrier family 41, member 3	149						integral to membrane|plasma membrane	cation transmembrane transporter activity			breast(1)|endometrium(4)|large_intestine(6)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18				GBM - Glioblastoma multiforme(114;0.167)		TCACCTGGATGAGGGCCAGGT	0.557000													8	16					0	0	0.387290	0	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22472946	22472946	+	RNA	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:22472946C>T	ENST00000557788.2	-	0	324																											ACGGCCCTGTCCGCGGCGGTC	0.602000													66	92					0	0	0.870114	0	0
IL1RN	3557	broad.mit.edu	37	2	113887221	113887221	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:113887221G>A	ENST00000361779.3	+	4	428	c.83G>A	c.(82-84)gGa>gAa	p.G28E	IL1RN_ENST00000409930.3_Missense_Mutation_p.G62E|IL1RN_ENST00000409052.1_Missense_Mutation_p.G28E|IL1RN_ENST00000354115.2_Missense_Mutation_p.G44E|IL1RN_ENST00000259206.5_Missense_Mutation_p.G65E	NM_173843.2	NP_776215.1	P18510	IL1RA_HUMAN	interleukin 1 receptor antagonist	62					immune response|inflammatory response|response to glucocorticoid stimulus	centrosome|extracellular space|nucleus|plasma membrane	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	10					Anakinra(DB00026)	TACTTGCAAGGACCAAATGTC	0.483000									Lichen Sclerosis et Atrophicus, Familial Clustering of				15	64					0	0	0.575678	0	0
STAT5B	6777	broad.mit.edu	37	17	40375412	40375412	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:40375412G>A	ENST00000293328.3	-	5	706	c.538C>T	c.(538-540)Ctg>Ttg	p.L180L		NM_012448.3	NP_036580.2	P51692	STA5B_HUMAN	signal transducer and activator of transcription 5B	180					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	TGGATCCTCAGGCTCTCCTGG	0.552000													6	25					0	0	0.248553	0	0
CACNA1E	777	broad.mit.edu	37	1	181740455	181740455	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:181740455G>A	ENST00000526775.1	+	35	5016	c.4851G>A	c.(4849-4851)gaG>gaA	p.E1617E	CACNA1E_ENST00000358338.5_Silent_p.E1568E|CACNA1E_ENST00000367570.1_Silent_p.E1636E|CACNA1E_ENST00000367573.2_Silent_p.E1636E|CACNA1E_ENST00000367567.4_Silent_p.E1243E|CACNA1E_ENST00000357570.5_Silent_p.E1587E|CACNA1E_ENST00000360108.3_Silent_p.E1617E	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1636					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AATTAGACGAGGAGAGTCACA	0.463000													5	2					0	0	0.307466	0	0
XDH	7498	broad.mit.edu	37	2	31562483	31562483	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:31562483G>A	ENST00000379416.3	-	34	3694	c.3646C>T	c.(3646-3648)Ccc>Tcc	p.P1216S		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	1216					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CTCCCCTCGGGGGAATAGTGT	0.612000													29	23					0	0	0.740014	0	0
TRIOBP	11078	broad.mit.edu	37	22	38109300	38109300	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr22:38109300C>T	ENST00000406386.3	+	5	593	c.338C>T	c.(337-339)cCc>cTc	p.P113L	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	113					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GAGGCAGTACCCTATCTGGAG	0.662000													50	62					0	0	0.870114	0	0
CCRL2	9034	broad.mit.edu	37	3	46450193	46450193	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:46450193T>C	ENST00000399036.3	+	2	975	c.623T>C	c.(622-624)gTt>gCt	p.V208A	ACKR5_ENST00000357392.4_Missense_Mutation_p.V220A|ACKR5_ENST00000400882.2_Missense_Mutation_p.V208A|ACKR5_ENST00000400880.3_Missense_Mutation_p.V208A	NM_003965.4	NP_003956.2																					AACATTTCGGTTCTTGTCCTC	0.388000													33	55					0	0	0.804634	0	0
SRGAP3	9901	broad.mit.edu	37	3	9055154	9055154	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:9055154G>A	ENST00000383836.3	-	17	2412	c.1985C>T	c.(1984-1986)aCc>aTc	p.T662I	SRGAP3_ENST00000360413.3_Missense_Mutation_p.T638I	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	662	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GTGCATGAGGGTAGGCCCGAA	0.532000			T	RAF1	pilocytic astrocytoma								15	26					0	0	0.520397	0	0
TANC2	26115	broad.mit.edu	37	17	61499137	61499137	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:61499137G>A	ENST00000424789.2	+	25	5798	c.5794G>A	c.(5794-5796)Gga>Aga	p.G1932R	RP11-269G24.3_ENST00000583552.1_RNA|TANC2_ENST00000389520.4_Missense_Mutation_p.G1942R	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1932							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						CGGGTCTCGTGGAGACCTCTT	0.532000													9	56					0	0	0.387290	0	0
OR6C4	341418	broad.mit.edu	37	12	55945169	55945169	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:55945169C>T	ENST00000394256.2	+	1	187	c.159C>T	c.(157-159)ctC>ctT	p.L53L	RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA	NM_001005494.1	NP_001005494.1	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C, member 4	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	11						ACCCCCACCTCCAGACCCCCA	0.418000													55	193					0	0	0.870114	0	0
SATB1	6304	broad.mit.edu	37	3	18436006	18436006	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:18436006C>T	ENST00000338745.6	-	7	2888	c.1154G>A	c.(1153-1155)cGa>cAa	p.R385Q	SATB1_ENST00000454909.2_Missense_Mutation_p.R385Q|SATB1_ENST00000417717.2_Missense_Mutation_p.R385Q|TBC1D5_ENST00000414318.2_Intron	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	385					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						GATTCCTGCTCGTTTCAGTTC	0.463000													76	107					0	0	0.870114	0	0
DNA2	1763	broad.mit.edu	37	10	70225555	70225555	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr10:70225555G>A	ENST00000399180.2	-	4	713	c.714C>T	c.(712-714)gcC>gcT	p.A238A	DNA2_ENST00000399179.2_Silent_p.A152A|DNA2_ENST00000358410.3_Silent_p.A152A			P51530	DNA2L_HUMAN	DNA replication helicase/nuclease 2	152					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)	20						TTTGGCGTGTGGCTGGATCAG	0.353000													6	1					0	0	0.307466	0	0
ARHGAP44	9912	broad.mit.edu	37	17	12862070	12862070	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:12862070C>T	ENST00000379672.5	+	16	1679	c.1379C>T	c.(1378-1380)cCa>cTa	p.P460L	ARHGAP44_ENST00000340825.3_Missense_Mutation_p.P460L|ARHGAP44_ENST00000262444.9_Missense_Mutation_p.P460L	NM_014859.4	NP_055674.4	Q17R89	RHG44_HUMAN	Rho GTPase activating protein 44	460					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|urinary_tract(1)	31						TATGGGAGTCCAGTACACGTG	0.577000													3	24					0	0	0.184627	0	0
TMEM38A	79041	broad.mit.edu	37	19	16791364	16791364	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:16791364C>T	ENST00000187762.2	+	3	529	c.438C>T	c.(436-438)ttC>ttT	p.F146F		NM_024074.1	NP_076979.1	Q9H6F2	TM38A_HUMAN	transmembrane protein 38A	146						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)	15						ACGGGTGGTTCGTCATGATTG	0.522000													33	28					0	0	0.788014	0	0
KCNV1	27012	broad.mit.edu	37	8	110980337	110980337	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:110980337C>T	ENST00000524391.1	-	4	2515	c.1483G>A	c.(1483-1485)Gga>Aga	p.G495R	KCNV1_ENST00000297404.1_Missense_Mutation_p.G495R			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	495						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			AAATCATCTCCCCCGCTGCTC	0.373000													14	20					0	0	0.520397	0	0
SHC3	53358	broad.mit.edu	37	9	91686121	91686121	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:91686121C>T	ENST00000375835.4	-	5	1082	c.776G>A	c.(775-777)gGa>gAa	p.G259E	SHC3_ENST00000375830.1_5'UTR	NM_016848.5	NP_058544.3	Q92529	SHC3_HUMAN	SHC (Src homology 2 domain containing) transforming protein 3	259	PID.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|skin(3)	28						TACCGGGTCTCCCCCAGAGGC	0.498000													29	15					0	0	0.812448	0	0
FUT2	2524	broad.mit.edu	37	19	49206638	49206638	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:49206638G>A	ENST00000425340.2	+	2	542	c.425G>A	c.(424-426)gGg>gAg	p.G142E	FUT2_ENST00000391876.4_Missense_Mutation_p.G142E	NM_000511.5|NM_001097638.2	NP_000502.4|NP_001091107.1	Q10981	FUT2_HUMAN	fucosyltransferase 2 (secretor status included)	142					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)	7		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		CACATCCCGGGGGAGTACGTC	0.647000													12	65					0	0	0.387290	0	0
DNAH10	196385	broad.mit.edu	37	12	124330279	124330279	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:124330279G>A	ENST00000409039.3	+	30	5164	c.5139G>A	c.(5137-5139)agG>agA	p.R1713R		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1713	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACTATGGCAGGAAAATGCACC	0.517000													8	15					0	0	0.307466	0	0
MRPS23	51649	broad.mit.edu	37	17	55926751	55926751	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:55926751G>A	ENST00000313608.8	-	2	110	c.65C>T	c.(64-66)gCc>gTc	p.A22V	MRPS23_ENST00000578444.1_Missense_Mutation_p.A22V	NM_016070.3	NP_057154.2	Q9Y3D9	RT23_HUMAN	mitochondrial ribosomal protein S23	22					translation	intermediate filament cytoskeleton|mitochondrion|nuclear membrane|ribosome	structural constituent of ribosome			endometrium(2)|large_intestine(1)|lung(2)	5	Breast(9;8.75e-08)					CAGCACCCCGGCCCGAACCAG	0.577000													13	31					0	0	0.435327	0	0
SAFB	6294	broad.mit.edu	37	19	5667859	5667859	+	Silent	SNP	C	C	A	rs141149674	byFrequency	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:5667859C>A	ENST00000292123.5	+	20	2687	c.2580C>A	c.(2578-2580)tcC>tcA	p.S860S	SAFB_ENST00000592224.1_Silent_p.S861S|SAFB_ENST00000588852.1_Silent_p.S862S|SAFB_ENST00000454510.1_Silent_p.S793S|SAFB_ENST00000433404.1_Silent_p.S692S|SAFB_ENST00000538656.1_Silent_p.S704S	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	860	Gly-rich.|Interaction with SAFB2.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		CCGGTCACTCCGGGCCTGGCC	0.607000													10	51					0.00185496	0.00185979	0.435327	1	0
TRBV11-2	28581	broad.mit.edu	37	7	142198030	142198030	+	RNA	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:142198030G>A	ENST00000471935.1	-	0	39																											GGAAGGATGGGAGCTTTGCCC	0.572000													13	41					0	0	0.557998	0	0
SDPR	8436	broad.mit.edu	37	2	192711433	192711433	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:192711433C>T	ENST00000304141.4	-	1	548	c.219G>A	c.(217-219)caG>caA	p.Q73Q	AC098617.1_ENST00000424116.2_RNA	NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	73						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GCTGGTTCTCCTGCACAGCGT	0.572000													16	39					0	0	0.575678	0	0
MS4A14	84689	broad.mit.edu	37	11	60164131	60164131	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:60164131C>T	ENST00000300187.6	+	1	357	c.80C>T	c.(79-81)cCc>cTc	p.P27L	MS4A14_ENST00000531783.1_Missense_Mutation_p.P27L|MS4A14_ENST00000531787.1_Intron|MS4A14_ENST00000395001.1_5'UTR|MS4A14_ENST00000395005.2_Missense_Mutation_p.P27L	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	27						integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						ACTGCATTTCCCTACAGACCT	0.468000													19	3					0	0	0.608945	0	0
DRD5	1816	broad.mit.edu	37	4	9784592	9784592	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:9784592C>T	ENST00000304374.2	+	1	1335	c.939C>T	c.(937-939)ttC>ttT	p.F313F		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	313					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TGCCCTTCTTCATCCTTAACT	0.597000													32	22					0	0	0.804634	0	0
OR51D1	390038	broad.mit.edu	37	11	4661207	4661207	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:4661207C>T	ENST00000357605.2	+	1	263	c.187C>T	c.(187-189)Cgt>Tgt	p.R63C		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCTCATCATTCGTGTGGAGAG	0.542000													30	9					0	0	0.812448	0	0
CNTN6	27255	broad.mit.edu	37	3	1369179	1369179	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:1369179G>A	ENST00000446702.2	+	10	1749	c.1122G>A	c.(1120-1122)acG>acA	p.T374T	CNTN6_ENST00000350110.2_Silent_p.T374T|CNTN6_ENST00000539053.1_Silent_p.T302T			Q9UQ52	CNTN6_HUMAN	contactin 6	374	Ig-like C2-type 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TCATCATAACGATGCTGAATG	0.348000													21	25					0	0	0.693898	0	0
DLGAP2	9228	broad.mit.edu	37	8	1626678	1626678	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:1626678C>T	ENST00000421627.2	+	9	2481	c.2347C>T	c.(2347-2349)Ccg>Tcg	p.P783S	DLGAP2_ENST00000524065.1_3'UTR	NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	862					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GAGGATGTCTCCGTGCCGCAG	0.597000													6	7					0	0	0.217242	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558738	140558738	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:140558738G>A	ENST00000239444.2	+	1	1368	c.1123G>A	c.(1123-1125)Gat>Aat	p.D375N		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		375	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCAGACCTTGATTCAGGAGA	0.458000													49	394					0	0	0.870114	0	0
SCN7A	6332	broad.mit.edu	37	2	167298251	167298251	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:167298251G>A	ENST00000409855.1	-	14	1938	c.1812C>T	c.(1810-1812)ttC>ttT	p.F604F		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	604					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						TTCCCAACTTGAAAATTCTTA	0.353000													20	16					0	0	0.624587	0	0
SVOPL	136306	broad.mit.edu	37	7	138281185	138281185	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:138281185C>T	ENST00000421622.1	-	11	1292	c.1084G>A	c.(1084-1086)Gaa>Aaa	p.E362K	SVOPL_ENST00000436657.1_Missense_Mutation_p.E330K|SVOPL_ENST00000288513.5_Missense_Mutation_p.E330K|SVOPL_ENST00000463557.1_5'UTR|SVOPL_ENST00000419765.3_Missense_Mutation_p.E482K			Q8N434	SVOPL_HUMAN	SVOP-like	482						integral to membrane	transmembrane transporter activity	p.E330K(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	19						CCTTTGGTTTCGATGGGGAGA	0.488000													29	31					0	0	0.812448	0	0
AC015849.16	0	broad.mit.edu	37	17	34236529	34236529	+	RNA	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:34236529G>A	ENST00000587132.1	-	0	1498																											CTGCATGGTTGGAGAAAGTTC	0.483000													5	19					0	0	0.184627	0	0
ADAM28	10863	broad.mit.edu	37	8	24181448	24181448	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:24181448G>A	ENST00000265769.4	+	9	932	c.822G>A	c.(820-822)gaG>gaA	p.E274E	RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000540823.1_Silent_p.E41E|ADAM28_ENST00000518516.1_3'UTR|ADAM28_ENST00000397649.3_Silent_p.E21E|RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000437154.2_Silent_p.E274E|RP11-624C23.1_ENST00000523700.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	274	Peptidase M12B.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding	p.E274D(1)		central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TCACCTTGGAGAATTTTTCTA	0.383000													13	42					0	0	0.411799	0	0
TUBA3C	7278	broad.mit.edu	37	13	19752419	19752419	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr13:19752419G>A	ENST00000400113.3	-	3	446	c.342C>T	c.(340-342)atC>atT	p.I114I		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	114					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CCAGGTCGACGATCTCCTTGC	0.537000													11	89					0	0	0.479597	0	0
CCDC73	493860	broad.mit.edu	37	11	32697157	32697157	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:32697157G>A	ENST00000335185.5	-	9	642	c.599C>T	c.(598-600)tCa>tTa	p.S200L	CCDC73_ENST00000534415.1_5'UTR	NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	200										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					ATTTAAAGCTGAAAGTCTTTT	0.264000													4	2					0	0	0.184627	0	0
PKD1	5310	broad.mit.edu	37	16	2168023	2168023	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:2168023G>A	ENST00000262304.4	-	5	1178	c.970C>T	c.(970-972)Cgc>Tgc	p.R324C	PKD1_ENST00000423118.1_Missense_Mutation_p.R324C	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	324	PKD 1.		R -> L (in ADPKD1).		calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AGCACATAGCGATGCGAGGCA	0.706000													5	0					0	0	0.278610	0	0
MXRA5	25878	broad.mit.edu	37	X	3235891	3235891	+	Missense_Mutation	SNP	G	G	A	rs137882293		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:3235891G>A	ENST00000217939.6	-	6	5985	c.5831C>T	c.(5830-5832)tCg>tTg	p.S1944L		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1944	Ig-like C2-type 3.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CACGGTGACCGAAAGCAAGAC	0.552000													3	47					0	0	0.115264	0	0
AXDND1	126859	broad.mit.edu	37	1	179460829	179460829	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:179460829G>A	ENST00000367618.3	+	19	2635	c.2248G>A	c.(2248-2250)Gaa>Aaa	p.E750K		NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	750										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						AGATGCGATTGAACTGACAAG	0.418000													115	36					0	0	0.870114	0	0
AQR	9716	broad.mit.edu	37	15	35176814	35176814	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:35176814G>A	ENST00000156471.5	-	26	3164	c.2939C>T	c.(2938-2940)cCc>cTc	p.P980L		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	980						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		TTTAAAAATGGGTTGAGGAGC	0.368000													19	25					0	0	0.557998	0	0
PREX1	57580	broad.mit.edu	37	20	47249086	47249086	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:47249086G>A	ENST00000396220.1	-	34	4381	c.4359C>T	c.(4357-4359)tcC>tcT	p.S1453S	PREX1_ENST00000371941.3_Silent_p.S1453S			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	1453					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CCTCCAGGCGGGAGGGCAGCT	0.647000													12	24					0	0	0.435327	0	0
ACTN4	81	broad.mit.edu	37	19	39207754	39207754	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:39207754C>T	ENST00000252699.2	+	10	1017	c.941C>T	c.(940-942)cCc>cTc	p.P314L	ACTN4_ENST00000390009.3_Missense_Mutation_p.P95L|ACTN4_ENST00000424234.2_Intron	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	314					platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CGCACCATCCCCTGGCTGGAG	0.647000													6	6					0	0	0.278610	0	0
OR4K13	390433	broad.mit.edu	37	14	20502084	20502084	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:20502084G>A	ENST00000315693.2	-	1	835	c.834C>T	c.(832-834)ttC>ttT	p.F278F		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	278					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AGAGAGGTGTGAAAATTGTGT	0.333000													8	1					0	0	0.307466	0	0
CCDC144A	9720	broad.mit.edu	37	17	16612813	16612813	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:16612813C>T	ENST00000443444.2	+	5	1582	c.1442C>T	c.(1441-1443)cCa>cTa	p.P481L	RP11-219A15.1_ENST00000448331.3_Missense_Mutation_p.P481L|CCDC144A_ENST00000456009.1_Intron|CCDC144A_ENST00000340621.5_Missense_Mutation_p.P480L|CCDC144A_ENST00000399273.1_Missense_Mutation_p.P481L|CCDC144A_ENST00000360524.8_Missense_Mutation_p.P481L			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	481																	TCTTTACCACCAGATTCTGAC	0.338000													13	11					0	0	0.457914	0	0
IGLV2-23	28813	broad.mit.edu	37	22	23040869	23040869	+	RNA	SNP	A	A	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr22:23040869A>C	ENST00000390306.2	+	0	479																											GACGAGGCTGATTATTACTGC	0.547000													39	95					0	0	0.870114	0	0
AFF2	2334	broad.mit.edu	37	X	148037297	148037297	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:148037297G>A	ENST00000370460.2	+	11	2201	c.1722G>A	c.(1720-1722)acG>acA	p.T574T	AFF2_ENST00000342251.3_Silent_p.T541T|AFF2_ENST00000370457.5_Silent_p.T541T|AFF2_ENST00000286437.5_Silent_p.T215T	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	574					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding	p.T574T(2)|p.T215T(1)		breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					AAGTGAAGACGAATGCCAGTC	0.473000													64	53					0	0	0.870114	0	0
EIF3F	8665	broad.mit.edu	37	11	8008871	8008871	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:8008871C>T	ENST00000537635.1	+	1	435	c.17C>T	c.(16-18)tCc>tTc	p.S6F	EIF3F_ENST00000309828.4_5'UTR|EIF3F_ENST00000533626.1_5'UTR			O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3, subunit F	0						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)	13				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCTGTCATTTCCGCTTCCGCC	0.557000											OREG0020726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	70	137					0	0	0.870114	0	0
TCF4	6925	broad.mit.edu	37	18	53128337	53128337	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:53128337C>T	ENST00000354452.3	-	5	828	c.217G>A	c.(217-219)Gat>Aat	p.D73N	TCF4_ENST00000537578.1_Missense_Mutation_p.D49N|TCF4_ENST00000566279.1_Missense_Mutation_p.D73N|TCF4_ENST00000564403.2_Missense_Mutation_p.D73N|TCF4_ENST00000565018.2_Missense_Mutation_p.D73N|TCF4_ENST00000566286.1_Missense_Mutation_p.D71N|TCF4_ENST00000543082.1_Missense_Mutation_p.D31N|TCF4_ENST00000564999.1_Missense_Mutation_p.D73N|TCF4_ENST00000568740.1_Missense_Mutation_p.D49N|TCF4_ENST00000568673.1_Missense_Mutation_p.D49N|TCF4_ENST00000398339.1_Missense_Mutation_p.D175N|RP11-619L19.1_ENST00000587660.1_RNA|TCF4_ENST00000356073.4_Missense_Mutation_p.D73N|TCF4_ENST00000540999.1_Missense_Mutation_p.D49N|TCF4_ENST00000567880.1_Missense_Mutation_p.D73N	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	73	Essential for MYOD1 inhibition (By similarity).				positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		GGAGTCCCATCTCCATAGTTC	0.388000													10	14					0	0	0.335167	0	0
ZNF80	7634	broad.mit.edu	37	3	113955275	113955275	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:113955275G>T	ENST00000482457.2	-	1	1150	c.647C>A	c.(646-648)cCc>cAc	p.P216H		NM_007136.3	NP_009067.2	P51504	ZNF80_HUMAN	zinc finger protein 80	216						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|urinary_tract(2)	32		Lung NSC(201;0.0233)|all_neural(597;0.0837)				GCACTCGTAGGGCTTTCCTGC	0.493000													31	59					2.95478e-19	2.98972e-19	0.840704	1	0
DICER1	23405	broad.mit.edu	37	14	95574384	95574384	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:95574384G>A	ENST00000526495.1	-	18	2774	c.2483C>T	c.(2482-2484)tCc>tTc	p.S828F	DICER1_ENST00000541352.1_Missense_Mutation_p.S828F|DICER1_ENST00000343455.3_Missense_Mutation_p.S828F|DICER1_ENST00000527414.1_Missense_Mutation_p.S828F|DICER1_ENST00000393063.1_Missense_Mutation_p.S828F			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	828					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CAACTCAATGGATATGGTAAC	0.378000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				24	7					0	0	0.681144	0	0
CORIN	10699	broad.mit.edu	37	4	47746434	47746434	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:47746434C>T	ENST00000273857.4	-	5	783	c.784G>A	c.(784-786)Gaa>Aaa	p.E262K	CORIN_ENST00000508498.1_Missense_Mutation_p.E123K|CORIN_ENST00000505909.1_Missense_Mutation_p.E262K|CORIN_ENST00000502252.1_Missense_Mutation_p.E195K|CORIN_ENST00000504584.1_Missense_Mutation_p.E262K	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	262					peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						TTTCCGTTTTCCTGCTGAGGT	0.378000													51	19					0	0	0.870114	0	0
DENND6B	414918	broad.mit.edu	37	22	50757306	50757306	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr22:50757306A>G	ENST00000413817.2	-	3	300	c.229T>C	c.(229-231)Tgc>Cgc	p.C77R		NM_001001794.3	NP_001001794.3			DENN/MADD domain containing 6B																		GACAGGTAGCAGATGCTGCTT	0.597000													18	18					0	0	0.667858	0	0
IGHA1	3493	broad.mit.edu	37	14	106174820	106174820	+	RNA	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:106174820C>T	ENST00000390547.2	-	0	182																											TGTACAGGTCCCCGGAGGCAT	0.642000													19	16					0	0	0.557998	0	0
CTCFL	140690	broad.mit.edu	37	20	56083820	56083820	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:56083820G>A	ENST00000429804.2	-	8	1926	c.1366C>T	c.(1366-1368)Cgt>Tgt	p.R456C	CTCFL_ENST00000422869.2_Missense_Mutation_p.R506C|CTCFL_ENST00000422109.2_Intron|CTCFL_ENST00000433949.2_Missense_Mutation_p.R506C|CTCFL_ENST00000371196.2_Missense_Mutation_p.R506C|CTCFL_ENST00000502686.2_Missense_Mutation_p.R244C|CTCFL_ENST00000426658.2_3'UTR|CTCFL_ENST00000243914.3_Missense_Mutation_p.R506C|CTCFL_ENST00000539382.1_Missense_Mutation_p.R301C|CTCFL_ENST00000423479.2_Missense_Mutation_p.R506C|CTCFL_ENST00000432255.2_Missense_Mutation_p.R362C	NM_001269046.1	NP_001255975.1	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	506					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GTGTGGGTACGAATGTGAGCG	0.433000													23	31					0	0	0.750413	0	0
FNDC1	84624	broad.mit.edu	37	6	159687132	159687132	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:159687132G>A	ENST00000297267.9	+	21	5501	c.5301G>A	c.(5299-5301)tgG>tgA	p.W1767*	FNDC1_ENST00000340366.6_Nonsense_Mutation_p.W1704*	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1767						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGCCTATCTGGATCCCATTCG	0.493000													9	15					0	0	0.335167	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43944829	43944829	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:43944829C>T	ENST00000389420.3	-	2	335	c.336G>A	c.(334-336)ccG>ccA	p.P112P	ADAMTS20_ENST00000553158.1_Silent_p.P112P	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	112						proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCCCGCGCTCCGGGGTTCCCA	0.652000													9	12					0	0	0.387290	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555292	44555292	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:44555292C>T	ENST00000330682.2	-	1	1157	c.922G>A	c.(922-924)Gaa>Aaa	p.E308K	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000245121.5_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	308	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						AAAGCAGCTTCCTCCTGGAGC	0.637000													11	293					0	0	0.435327	0	0
MUC16	94025	broad.mit.edu	37	19	9057066	9057066	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:9057066G>A	ENST00000397910.4	-	3	30583	c.30380C>T	c.(30379-30381)tCc>tTc	p.S10127F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10129	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTAGCCTTGGATGGCTCCGA	0.468000													4	20					0	0	0.150653	0	0
THAP7-AS1	439931	broad.mit.edu	37	22	21363572	21363572	+	RNA	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr22:21363572C>T	ENST00000452284.1	+	0	1239				TUBA3FP_ENST00000422086.1_RNA|THAP7-AS1_ENST00000436079.1_RNA	NR_027051.1																						TGTAGGGCTCCGTCATGGCCA	0.557000													33	57					0	0	0.840704	0	0
IGF2R	3482	broad.mit.edu	37	6	160485503	160485503	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:160485503C>T	ENST00000356956.1	+	28	4105	c.3957C>T	c.(3955-3957)tgC>tgT	p.C1319C		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	1319					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GGGACACTTGCCATAAGGTTT	0.512000													40	55					0	0	0.864702	0	0
CD93	22918	broad.mit.edu	37	20	23065072	23065072	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:23065072G>A	ENST00000246006.4	-	1	1905	c.1758C>T	c.(1756-1758)atC>atT	p.I586I		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	586					cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CGGTGCCTAGGATGTAGAATA	0.597000													48	43					0	0	0.870114	0	0
COL3A1	1281	broad.mit.edu	37	2	189875409	189875409	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:189875409C>T	ENST00000304636.3	+	50	4217	c.4047C>T	c.(4045-4047)gtC>gtT	p.V1349V	COL3A1_ENST00000317840.5_Silent_p.V1046V	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1349	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTGAAGATGTCCTTGATGTGC	0.438000													9	109					0	0	0.779181	0	0
DNAH17	8632	broad.mit.edu	37	17	76548870	76548870	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:76548870C>T	ENST00000389840.5	-	15	2320	c.2196G>A	c.(2194-2196)aaG>aaA	p.K732K	DNAH17_ENST00000585328.1_Silent_p.K732K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ATTCTACTGCCTTCACTATAG	0.393000													18	88					0	0	0.539581	0	0
BCL2L11	10018	broad.mit.edu	37	2	111907670	111907670	+	Silent	SNP	C	C	T	rs143377281	by1000genomes	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:111907670C>T	ENST00000393256.3	+	3	717	c.444C>T	c.(442-444)atC>atT	p.I148I	BCL2L11_ENST00000393253.2_Silent_p.I58I|BCL2L11_ENST00000357757.2_Silent_p.I148I|BCL2L11_ENST00000308659.8_Silent_p.I88I	NM_001204106.1|NM_006538.4|NM_138621.4|NM_138627.3	NP_001191035.1|NP_006529.1|NP_619527.1|NP_619533.1	O43521	B2L11_HUMAN	BCL2-like 11 (apoptosis facilitator)	148					activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|endomembrane system|mitochondrial outer membrane|plasma membrane	protein binding			endometrium(4)|large_intestine(3)|lung(2)|prostate(2)	11						AGATATGGATCGCCCAAGAGT	0.473000													27	20					0	0	0.769981	0	0
GPR174	84636	broad.mit.edu	37	X	78427035	78427035	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:78427035C>T	ENST00000276077.1	+	1	567	c.531C>T	c.(529-531)gtC>gtT	p.V177V		NM_032553.1	NP_115942.1	Q9BXC1	GP174_HUMAN	G protein-coupled receptor 174	177						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	38						CCAGGAATGTCAACCTGGCCC	0.463000										HNSCC(63;0.18)			19	28					0	0	0.639603	0	0
DSC2	1824	broad.mit.edu	37	18	28651784	28651784	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:28651784G>A	ENST00000280904.6	-	13	2355	c.1912C>T	c.(1912-1914)Cag>Tag	p.Q638*	DSC2_ENST00000251081.6_Nonsense_Mutation_p.Q638*	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	638	Cadherin 5.		Q -> H.		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GGATCATTCTGATAGGAAAGA	0.348000													17	23					0	0	0.624587	0	0
SVEP1	79987	broad.mit.edu	37	9	113170022	113170022	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:113170022C>T	ENST00000401783.2	-	38	8194	c.7858G>A	c.(7858-7860)Gat>Aat	p.D2620N	SVEP1_ENST00000374469.1_Missense_Mutation_p.D2597N|SVEP1_ENST00000297826.5_Missense_Mutation_p.D546N	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2620					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TCTCCAAAATCTATATGAGGA	0.463000													85	30					0	0	0.870114	0	0
GPRC6A	222545	broad.mit.edu	37	6	117121792	117121792	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:117121792G>A	ENST00000310357.3	-	4	1524	c.1503C>T	c.(1501-1503)ttC>ttT	p.F501F	GPRC6A_ENST00000368549.3_Intron|GPRC6A_ENST00000530250.1_Silent_p.F326F	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	501					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CTGGGATGATGAAGACATCAT	0.408000													26	48					0	0	0.740014	0	0
SLC6A5	9152	broad.mit.edu	37	11	20636271	20636271	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:20636271G>A	ENST00000525748.1	+	6	1305	c.1032G>A	c.(1030-1032)tcG>tcA	p.S344S		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	344					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity	p.S344S(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	TCAAGAACTCGACTTTCTGCA	0.408000													55	31					0	0	0.870114	0	0
PEX6	5190	broad.mit.edu	37	6	42946034	42946034	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:42946034G>A	ENST00000304611.8	-	1	924	c.855C>T	c.(853-855)ccC>ccT	p.P285P	PEX6_ENST00000244546.4_Silent_p.P285P	NM_000287.3	NP_000278.3	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	285					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(3)	15			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			CCATTTCCAGGGGGTCACAGC	0.537000													20	29					0	0	0.667858	0	0
ZNF560	147741	broad.mit.edu	37	19	9578939	9578939	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:9578939G>A	ENST00000301480.4	-	10	897	c.684C>T	c.(682-684)tgC>tgT	p.C228C		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	228					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						TGGTCTTAAGGCATGGATGTT	0.373000													13	50					0	0	0.479597	0	0
GRIK5	2901	broad.mit.edu	37	19	42507571	42507571	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:42507571G>A	ENST00000262895.3	-	18	2426	c.2427C>T	c.(2425-2427)atC>atT	p.I809I	GRIK5_ENST00000593562.1_Silent_p.I809I|GRIK5_ENST00000301218.4_Silent_p.I809I	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	809						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	AGATGAGCACGATAAAAATGC	0.587000													9	52					0	0	0.307466	0	0
ZNF711	7552	broad.mit.edu	37	X	84526218	84526218	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:84526218G>A	ENST00000360700.4	+	10	2694	c.1808G>A	c.(1807-1809)gGt>gAt	p.G603D	ZNF711_ENST00000395402.1_Missense_Mutation_p.G565D|ZNF711_ENST00000276123.3_Missense_Mutation_p.G557D|ZNF711_ENST00000542798.1_Missense_Mutation_p.G399D|ZNF711_ENST00000373165.3_Missense_Mutation_p.G557D			Q9Y462	ZN711_HUMAN	zinc finger protein 711	557					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						TCTAAACATGGTAACAATTTG	0.398000													6	8					0	0	0.278610	0	0
EDN3	1908	broad.mit.edu	37	20	57876727	57876727	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:57876727G>A	ENST00000311585.7	+	2	685	c.315G>A	c.(313-315)aaG>aaA	p.K105K	EDN3_ENST00000371028.2_Silent_p.K105K|EDN3_ENST00000371025.3_Silent_p.K105K|EDN3_ENST00000337938.2_Silent_p.K105K|EDN3_ENST00000395654.3_Silent_p.K105K	NM_207032.1	NP_996915.1	P14138	EDN3_HUMAN	endothelin 3	105					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	19	all_lung(29;0.0115)					ACAAGGACAAGGAGTGTGTCT	0.612000													64	59					0	0	0.870114	0	0
CENPE	1062	broad.mit.edu	37	4	104029996	104029996	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:104029996G>A	ENST00000265148.3	-	48	8064	c.7975C>T	c.(7975-7977)Cgc>Tgc	p.R2659C	CENPE_ENST00000380026.3_Missense_Mutation_p.R2538C	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	2659	Globular autoinhibitory domain (By similarity).				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity	p.R2622C(1)		NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TCAAAATAGCGAACTGGATGA	0.368000													27	7					0	0	0.729181	0	0
BRCA1	672	broad.mit.edu	37	17	41244176	41244176	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:41244176G>A	ENST00000309486.4	-	9	3511	c.2484C>T	c.(2482-2484)ttC>ttT	p.F828F	BRCA1_ENST00000471181.2_Silent_p.F1124F|BRCA1_ENST00000352993.3_Intron|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000357654.3_Silent_p.F1124F|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000346315.3_Silent_p.F1124F|BRCA1_ENST00000493795.1_Silent_p.F1077F|BRCA1_ENST00000354071.3_Silent_p.F1124F|BRCA1_ENST00000351666.3_Intron|BRCA1_ENST00000468300.1_Intron|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000491747.2_Intron	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset	1124					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GATATGGAGAGAAATCTGTAT	0.373000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			42	31					0	0	0.864702	0	0
KHDC3L	154288	broad.mit.edu	37	6	74072880	74072880	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:74072880C>T	ENST00000370367.3	+	2	285	c.232C>T	c.(232-234)Cga>Tga	p.R78*		NM_001017361.2	NP_001017361.1			KH domain containing 3-like, subcortical maternal complex member																		TCACGTGAATCGATTGGACCC	0.572000													40	52					0	0	0.870114	0	0
INSRR	3645	broad.mit.edu	37	1	156819156	156819156	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:156819156G>A	ENST00000368195.3	-	6	1722	c.1326C>T	c.(1324-1326)ttC>ttT	p.F442F	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	442					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGTTGAAGGCGAAGTAGATCT	0.602000													105	30					0	0	0.870114	0	0
MUC5B	727897	broad.mit.edu	37	11	1274045	1274045	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:1274045G>A	ENST00000447027.1	+	33	15119	c.15061G>A	c.(15061-15063)Gag>Aag	p.E5021K	MUC5B_ENST00000529681.1_Missense_Mutation_p.E5018K			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	5018					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCAGGTGAATGAGACCTGGAC	0.647000													8	5					0	0	0.361761	0	0
CCDC148	130940	broad.mit.edu	37	2	159166097	159166097	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:159166097T>C	ENST00000283233.5	-	9	1271	c.958A>G	c.(958-960)Atc>Gtc	p.I320V	CCDC148_ENST00000409187.1_Missense_Mutation_p.I329V|CCDC148_ENST00000536771.1_Missense_Mutation_p.I234V	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	320										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						GATATCAGGATATTTTGCTGC	0.363000													13	24					0	0	0.479597	0	0
GAB3	139716	broad.mit.edu	37	X	153925421	153925421	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:153925421G>A	ENST00000369575.3	-	7	1441	c.1410C>T	c.(1408-1410)acC>acT	p.T470T	GAB3_ENST00000424127.2_Silent_p.T471T|GAB3_ENST00000496390.1_5'UTR	NM_001081573.1|NM_080612.2	NP_001075042.1|NP_542179.1	Q8WWW8	GAB3_HUMAN	GRB2-associated binding protein 3	470										NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)	25	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCACAGTGCGGGTCCTGGTAA	0.522000													7	45					0	0	0.335167	0	0
CT47B1	643311	broad.mit.edu	37	X	120008801	120008801	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:120008801C>T	ENST00000371311.3	-	1	978	c.724G>A	c.(724-726)Gag>Aag	p.E242K		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	242								p.K235_E243delKLTEEATEE(1)		breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						GCCGGTtcctctgtggcctcc	0.682000													9	80					0	0	0.361761	0	0
EPPK1	83481	broad.mit.edu	37	8	144940333	144940333	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:144940333G>A	ENST00000525985.1	-	2	7160	c.7089C>T	c.(7087-7089)taC>taT	p.Y2363Y				P58107	EPIPL_HUMAN	epiplakin 1	2363						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGCCGCGCCGGTAGGCCACGT	0.692000													12	340					0	0	0.592651	0	0
SLC27A6	28965	broad.mit.edu	37	5	128302295	128302295	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:128302295C>T	ENST00000262462.4	+	1	1475	c.465C>T	c.(463-465)gcC>gcT	p.A155A	SLC27A6_ENST00000506176.1_Silent_p.A155A|SLC27A6_ENST00000395266.1_Silent_p.A155A			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	155					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		GGCCCAGAGCCCTAGTGGTGG	0.552000													12	6					0	0	0.539581	0	0
CD207	50489	broad.mit.edu	37	2	71060133	71060133	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:71060133G>A	ENST00000410009.3	-	4	660	c.615C>T	c.(613-615)aaC>aaT	p.N205N		NM_015717.3	NP_056532.3	Q9UJ71	CLC4K_HUMAN	CD207 molecule, langerin	205	C-type lectin.				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|stomach(1)	20						AGTAATAGAAGTTCCCCTTGA	0.448000													24	16					0	0	0.681144	0	0
STXBP5L	9515	broad.mit.edu	37	3	120973775	120973775	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:120973775C>T	ENST00000273666.6	+	16	1746	c.1475C>T	c.(1474-1476)tCa>tTa	p.S492L	STXBP5L_ENST00000497029.1_Missense_Mutation_p.S492L|STXBP5L_ENST00000472879.1_Missense_Mutation_p.S492L|STXBP5L_ENST00000492541.1_Missense_Mutation_p.S492L|STXBP5L_ENST00000471454.1_Missense_Mutation_p.S492L	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	492					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		CTAAAAACTTCAAAAGTGTTT	0.338000													24	10					0	0	0.693898	0	0
KLHL24	54800	broad.mit.edu	37	3	183381296	183381296	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:183381296T>C	ENST00000454652.1	+	5	1357	c.971T>C	c.(970-972)gTt>gCt	p.V324A	KLHL24_ENST00000242810.6_Missense_Mutation_p.V324A|KLHL24_ENST00000476808.1_Missense_Mutation_p.V324A			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	324						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			TGTGAGCGAGTTGGAGGATTT	0.363000													73	93					0	0	0.870114	0	0
TRMT2B	79979	broad.mit.edu	37	X	100290673	100290673	+	Splice_Site	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:100290673C>T	ENST00000338687.7	-	6	1209		c.e6-1		TRMT2B_ENST00000372936.3_Splice_Site|TRMT2B_ENST00000372939.1_Splice_Site|TRMT2B_ENST00000545398.1_Splice_Site|TRMT2B_ENST00000372931.5_Splice_Site|TRMT2B_ENST00000372935.1_Splice_Site|TRMT2B_ENST00000478422.1_Splice_Site			Q96GJ1	TRM2_HUMAN	tRNA methyltransferase 2 homolog B (S. cerevisiae)								tRNA (uracil-5-)-methyltransferase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	24						ACGTTCCCATCTATGGAAAGA	0.363000													7	50					0	0	0.307466	0	0
VEGFC	7424	broad.mit.edu	37	4	177608435	177608435	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:177608435G>A	ENST00000280193.2	-	6	1466	c.1051C>T	c.(1051-1053)Caa>Taa	p.Q351*	RP11-313E19.2_ENST00000509194.1_RNA|RP11-313E19.2_ENST00000504017.1_RNA	NM_005429.2	NP_005420.1	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	351	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity	p.Q351*(1)		biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		TTTAGGGGTTGATTTCTGGGG	0.428000													66	35					0	0	0.870114	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325268	150325268	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:150325268G>A	ENST00000328902.5	-	3	634	c.418C>T	c.(418-420)Cag>Tag	p.Q140*	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	140							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACCACCTGCTGATCCTCATCC	0.637000													21	47					0	0	0.639603	0	0
PDE1B	5153	broad.mit.edu	37	12	54943752	54943752	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:54943752G>A	ENST00000243052.3	+	2	532	c.96G>A	c.(94-96)tgG>tgA	p.W32*		NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	32	Calmodulin-binding (Potential).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						AGAAGATGTGGATTAAGCTTC	0.632000													20	21					0	0	0.608945	0	0
KCNK1	3775	broad.mit.edu	37	1	233807084	233807084	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:233807084G>A	ENST00000366621.3	+	3	987	c.819G>A	c.(817-819)ctG>ctA	p.L273L	KCNK1_ENST00000472190.1_3'UTR|KCNK1_ENST00000366620.1_Silent_p.L157L	NM_002245.3	NP_002236.1	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	273						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	TCCATGAGCTGAAAAAATTCA	0.448000													37	11					0	0	0.812448	0	0
CCBE1	147372	broad.mit.edu	37	18	57107031	57107031	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:57107031C>G	ENST00000439986.4	-	8	830	c.793G>C	c.(793-795)Gga>Cga	p.G265R	CCBE1_ENST00000398179.2_Intron	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	265	Collagen-like 1.				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				CCTGGGCTTCCCTTTGGTCCT	0.587000													3	8					0	0	0.184627	0	0
XKR3	150165	broad.mit.edu	37	22	17288891	17288891	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr22:17288891G>A	ENST00000331428.5	-	2	175	c.73C>T	c.(73-75)Ctt>Ttt	p.L25F		NM_175878.3	NP_787074.2	Q5GH77	XKR3_HUMAN	XK, Kell blood group complex subunit-related family, member 3	25						integral to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CTCTGGCCAAGGACTATTTCT	0.403000													39	62					0	0	0.870114	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214080	140214080	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:140214080G>A	ENST00000525929.1	+	1	112	c.112G>A	c.(112-114)Gag>Aag	p.E38K	PCDHA7_ENST00000378125.3_Missense_Mutation_p.E38K|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018910.2	NP_061733.1												p.E38K(2)|p.E38*(1)		NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTCCCCGAGGAGGCTAAACA	0.617000													52	15					0	0	0.870114	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21457496	21457496	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:21457496C>T	ENST00000307378.6	-	7	1174	c.454G>A	c.(454-456)Gaa>Aaa	p.E152K	SLCO1A2_ENST00000452078.1_Missense_Mutation_p.E152K|SLCO1A2_ENST00000390670.3_Missense_Mutation_p.E150K|SLCO1A2_ENST00000458504.1_Missense_Mutation_p.E20K|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.E20K	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	152					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity	p.E152Q(1)|p.E152K(1)		breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						GATTTAACTTCCTTTGTACAC	0.358000													14	49					0	0	0.575678	0	0
IGHD	3495	broad.mit.edu	37	14	106311833	106311833	+	RNA	SNP	C	C	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:106311833C>A	ENST00000390556.2	-	0	177																											GTAGCTGTCCCGTCTTTGTAT	0.582000													19	25					5.35356e-11	5.40267e-11	0.639603	1	0
ABCA13	154664	broad.mit.edu	37	7	48559846	48559846	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:48559846C>T	ENST00000435803.1	+	53	14031	c.14007C>T	c.(14005-14007)ctC>ctT	p.L4669L	ABCA13_ENST00000544596.1_Silent_p.L399L	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4669					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CAGTACTTCTCCTCTTGAGGG	0.522000													19	23					0	0	0.575678	0	0
A2M	2	broad.mit.edu	37	12	9262479	9262479	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:9262479G>A	ENST00000318602.7	-	6	964	c.657C>T	c.(655-657)ttC>ttT	p.F219F		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	219					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	CCTCCACGGTGAAAGGGTGCT	0.428000													52	61					0	0	0.870114	0	0
FER1L6	654463	broad.mit.edu	37	8	125076659	125076659	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:125076659C>T	ENST00000522917.1	+	26	3606	c.3400C>T	c.(3400-3402)Cac>Tac	p.H1134Y	FER1L6_ENST00000399018.1_Missense_Mutation_p.H1134Y|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1134						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CCCAGCAGATCACATTTATGT	0.572000													57	77					0	0	0.870114	0	0
TNXB	7148	broad.mit.edu	37	6	32026050	32026050	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:32026050G>A	ENST00000375244.3	-	22	7811	c.7610C>T	c.(7609-7611)tCg>tTg	p.S2537L	TNXB_ENST00000375247.2_Missense_Mutation_p.S2537L			P22105	TENX_HUMAN	tenascin XB	2597	Fibronectin type-III 17.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						AAGGCTCAGCGAGTCAGGGGA	0.687000													7	46					0	0	0.335167	0	0
SGCZ	137868	broad.mit.edu	37	8	14412268	14412268	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:14412268C>T	ENST00000382080.1	-	2	922	c.207G>A	c.(205-207)tgG>tgA	p.W69*	SGCZ_ENST00000421524.2_Nonsense_Mutation_p.W56*	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	56					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CTTTCAATATCCATATTGTCA	0.353000													12	34					0	0	0.435327	0	0
HLCS	3141	broad.mit.edu	37	21	38302642	38302642	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr21:38302642A>T	ENST00000399120.1	-	6	2318	c.1088T>A	c.(1087-1089)gTc>gAc	p.V363D	HLCS_ENST00000482273.1_5'UTR|HLCS_ENST00000336648.3_Missense_Mutation_p.V363D	NM_001242784.1	NP_001229713.1	P50747	BPL1_HUMAN	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	363			V -> D (in HLCS deficiency; has normal or low KM values for biotin (non-KM mutant)).		cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	CTCTCTAAGGACTTCGTATCT	0.458000													11	25					0	0	0.361761	0	0
KIF15	56992	broad.mit.edu	37	3	44844305	44844305	+	Splice_Site	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:44844305G>A	ENST00000326047.4	+	14	1658		c.e14-1		KIF15_ENST00000425755.1_Splice_Site	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15						blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		CTATGTCACAGATAGAGCACC	0.383000													42	57					0	0	0.870114	0	0
PSG3	5671	broad.mit.edu	37	19	43242944	43242944	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:43242944G>A	ENST00000327495.5	-	2	546	c.362C>T	c.(361-363)aCc>aTc	p.T121I	PSG3_ENST00000595140.1_Missense_Mutation_p.T121I|PSG3_ENST00000490592.1_5'UTR	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	121	Ig-like V-type.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				GATGTGTAAGGTGTAGGATCC	0.483000													162	116					0	0	0.870114	0	0
MYH2	4620	broad.mit.edu	37	17	10448697	10448697	+	Silent	SNP	G	G	A	rs149579742		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:10448697G>A	ENST00000245503.5	-	5	855	c.471C>T	c.(469-471)tcC>tcT	p.S157S	MYH2_ENST00000397183.2_Silent_p.S157S|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Silent_p.S157S	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	157	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.S157S(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TGTCAGAGATGGAGAAGATGT	0.537000													41	207					0	0	0.870114	0	0
ZNF80	7634	broad.mit.edu	37	3	113955903	113955903	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:113955903C>T	ENST00000482457.2	-	1	522	c.19G>A	c.(19-21)Ggg>Agg	p.G7R		NM_007136.3	NP_009067.2	P51504	ZNF80_HUMAN	zinc finger protein 80	7						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|urinary_tract(2)	32		Lung NSC(201;0.0233)|all_neural(597;0.0837)				GTCCCCAACCCATCGCGTTTA	0.527000													37	86					0	0	0.870114	0	0
KCNH1	3756	broad.mit.edu	37	1	210857382	210857382	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:210857382G>A	ENST00000367007.4	-	11	2299	c.2130C>T	c.(2128-2130)gtC>gtT	p.V710V	KCNH1_ENST00000271751.4_Silent_p.V737V	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	737	Calmodulin-binding.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		AGAGGCGCCGGACAGGGTGGT	0.577000													25	7					0	0	0.740014	0	0
ATP8B4	79895	broad.mit.edu	37	15	50152492	50152492	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:50152492C>T	ENST00000284509.6	-	28	3619	c.3478G>A	c.(3478-3480)Gaa>Aaa	p.E1160K	ATP8B4_ENST00000559829.1_Missense_Mutation_p.E1160K	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	1160					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TGTGTCTTTTCCAGCCCTGAT	0.418000													43	50					0	0	0.870114	0	0
ZPLD1	131368	broad.mit.edu	37	3	102189262	102189262	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:102189262G>A	ENST00000306176.1	+	9	1106	c.1006G>A	c.(1006-1008)Gat>Aat	p.D336N	ZPLD1_ENST00000491959.1_Missense_Mutation_p.D320N|ZPLD1_ENST00000466937.1_Missense_Mutation_p.D320N	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	320						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						AGAAAGGAGAGATGCTGGGAG	0.512000													19	40					0	0	0.639603	0	0
TTN	7273	broad.mit.edu	37	2	179457996	179457996	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:179457996C>T	ENST00000589042.1	-	299	59163	c.58939G>A	c.(58939-58941)Gga>Aga	p.G19647R	TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G10774R|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G17079R|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G18006R|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G10582R|TTN_ENST00000359218.5_Missense_Mutation_p.G10707R|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18006	Fibronectin type-III 42.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACTGACATCCTTCTAGAAGA	0.398000													28	41					0	0	0.717897	0	0
DPPA2	151871	broad.mit.edu	37	3	109023446	109023446	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:109023446G>A	ENST00000478945.1	-	7	976	c.730C>T	c.(730-732)Cat>Tat	p.H244Y		NM_138815.3	NP_620170.3	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	244						nucleus	nucleic acid binding	p.H244Y(2)		breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TGACCTGCATGAAACTGCAGG	0.502000													33	47					0	0	0.853193	0	0
RRP9	9136	broad.mit.edu	37	3	51967557	51967557	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:51967557G>A	ENST00000232888.6	-	15	1466	c.1393C>T	c.(1393-1395)Cgc>Tgc	p.R465C		NM_004704.3	NP_004695.1	O43818	U3IP2_HUMAN	ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)	465					rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|ovary(1)|skin(1)	21				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		GGGACCCTGCGGAGTGGGATG	0.552000													26	47					0	0	0.740014	0	0
ARL13A	392509	broad.mit.edu	37	X	100243250	100243250	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:100243250A>G	ENST00000450049.2	+	7	835	c.722A>G	c.(721-723)aAg>aGg	p.K241R		NM_001162491.1	NP_001155963.1	Q5H913	AR13A_HUMAN	ADP-ribosylation factor-like 13A	241							GTP binding			endometrium(1)|ovary(1)	2						ATCGAAGCTAAGCCTCTAAAG	0.448000													4	7					0	0	0.184627	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725506	140725506	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:140725506G>A	ENST00000253812.6	+	1	1906	c.1906G>A	c.(1906-1908)Gac>Aac	p.D636N	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGACAGAGACGCGCTCAA	0.706000													30	30					0	0	0.827153	0	0
DMRTA1	63951	broad.mit.edu	37	9	22451440	22451440	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:22451440C>T	ENST00000325870.1	+	2	1270	c.1045C>T	c.(1045-1047)Cta>Tta	p.L349L		NM_022160.2	NP_071443.2	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	349					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		AGAAGGCATTCTACGGTTCTG	0.468000													29	14					0	0	0.819951	0	0
SI	6476	broad.mit.edu	37	3	164739070	164739070	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:164739070G>A	ENST00000264382.3	-	27	3263	c.3201C>T	c.(3199-3201)atC>atT	p.I1067I		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1067	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GATTTTCCTTGATTTCCACAT	0.343000										HNSCC(35;0.089)			61	93					0	0	0.870114	0	0
ANK3	288	broad.mit.edu	37	10	61829606	61829606	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr10:61829606G>A	ENST00000280772.1	-	37	11224	c.11033C>T	c.(11032-11034)cCt>cTt	p.P3678L	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3678					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTCCACTGTAGGTGTCTCTAC	0.542000													21	5					0	0	0.608945	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138202424	138202424	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:138202424G>A	ENST00000237289.4	+	9	2407	c.2341G>A	c.(2341-2343)Gaa>Aaa	p.E781K		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	781					anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		CTACTGCAACGAATGCTTTCA	0.592000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								39	84					0	0	0.870114	0	0
MYOM2	9172	broad.mit.edu	37	8	2037890	2037890	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:2037890G>A	ENST00000262113.4	+	15	1845	c.1704G>A	c.(1702-1704)ccG>ccA	p.P568P	MYOM2_ENST00000523438.1_5'UTR	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	568	Fibronectin type-III 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TGAGATCCCCGAGATATGCCG	0.562000													37	18					0	0	0.804634	0	0
UNC13A	23025	broad.mit.edu	37	19	17780454	17780454	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:17780454G>A	ENST00000428389.2	-	6	565	c.566C>T	c.(565-567)tCc>tTc	p.S189F	UNC13A_ENST00000552293.1_Missense_Mutation_p.S101F|UNC13A_ENST00000551649.1_Missense_Mutation_p.S101F|UNC13A_ENST00000550896.1_Missense_Mutation_p.S101F|UNC13A_ENST00000252773.7_Missense_Mutation_p.S101F|UNC13A_ENST00000519716.2_Missense_Mutation_p.S101F			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	101					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						GATGACCTGGGAGTCCAGCGT	0.617000													3	9					0	0	0.150653	0	0
PAM	5066	broad.mit.edu	37	5	102203051	102203051	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:102203051C>T	ENST00000438793.3	+	2	634	c.164C>T	c.(163-165)tCa>tTa	p.S55L	PAM_ENST00000304400.7_Missense_Mutation_p.S55L|PAM_ENST00000348126.2_Missense_Mutation_p.S55L|PAM_ENST00000513648.1_3'UTR|PAM_ENST00000274392.9_5'UTR|PAM_ENST00000455264.2_Missense_Mutation_p.S55L|PAM_ENST00000379787.4_5'UTR|PAM_ENST00000346918.2_Missense_Mutation_p.S55L	NM_000919.3|NM_001177306.1|NM_138766.2	NP_000910.2|NP_001170777.1|NP_620121.1	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	55	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	25		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	ATTGATTCATCAGATTTTGCA	0.363000													26	17					0	0	0.729181	0	0
KLHL15	80311	broad.mit.edu	37	X	24006881	24006881	+	Silent	SNP	G	G	A	rs144704626	by1000genomes	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:24006881G>A	ENST00000328046.8	-	4	1227	c.972C>T	c.(970-972)atC>atT	p.I324I		NM_030624.2	NP_085127.2	Q96M94	KLH15_HUMAN	kelch-like family member 15	324										autonomic_ganglia(1)|breast(1)|endometrium(8)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)	22						AATTATTGACGATAGCAAGGC	0.468000													24	24					0	0	0.760397	0	0
USP6	9098	broad.mit.edu	37	17	5058737	5058737	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:5058737C>T	ENST00000574788.1	+	31	4894	c.2664C>T	c.(2662-2664)ttC>ttT	p.F888F	USP6_ENST00000304328.5_Silent_p.F571F|USP6_ENST00000332776.4_3'UTR|USP6_ENST00000250066.6_Silent_p.F888F			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	888					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						AACTGTATTTCCTGTCACCTC	0.458000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								26	75					0	0	0.740014	0	0
FAM194A	131831	broad.mit.edu	37	3	150391765	150391765	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:150391765G>A	ENST00000295910.6	-	11	1373	c.1321C>T	c.(1321-1323)Cca>Tca	p.P441S	FAM194A_ENST00000491361.1_Missense_Mutation_p.P295S	NM_152394.3	NP_689607.2	Q7L0X2	F194A_HUMAN	family with sequence similarity 194, member A	441										NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GTCCCATCTGGAAATGAAGTC	0.338000													31	53					0	0	0.804634	0	0
MXRA5	25878	broad.mit.edu	37	X	3228885	3228885	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:3228885C>T	ENST00000217939.6	-	7	7513	c.7359G>A	c.(7357-7359)cgG>cgA	p.R2453R		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2453	Ig-like C2-type 9.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTGCTATCTCCCGCACAGTGG	0.587000													10	10					0	0	0.387290	0	0
SPTBN2	6712	broad.mit.edu	37	11	66458874	66458874	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:66458874G>A	ENST00000533211.1	-	27	5777	c.5446C>T	c.(5446-5448)Cgg>Tgg	p.R1816W	SPTBN2_ENST00000529997.1_Missense_Mutation_p.R1816W|SPTBN2_ENST00000309996.2_Missense_Mutation_p.R1816W			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1816					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						TGCTGCACCCGCGCCAGGGCT	0.692000													17	7					0	0	0.539581	0	0
CHD8	57680	broad.mit.edu	37	14	21883941	21883941	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:21883941G>A	ENST00000399982.2	-	5	1906	c.1842C>T	c.(1840-1842)ctC>ctT	p.L614L	CHD8_ENST00000557364.1_Silent_p.L614L|CHD8_ENST00000555962.1_Intron|CHD8_ENST00000430710.3_Silent_p.L335L	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	614					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CTGGTTCAGGGAGGATAGGCT	0.433000													20	11					0	0	0.624587	0	0
MYO1H	283446	broad.mit.edu	37	12	109874332	109874332	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:109874332G>A	ENST00000310903.5	+	22	2238	c.2132G>A	c.(2131-2133)aGg>aAg	p.R711K	MYO1H_ENST00000431443.2_Missense_Mutation_p.R721K			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						TGCCTAGGAAGGAGAGAATAC	0.408000													5	9					0	0	0.248553	0	0
XKR9	389668	broad.mit.edu	37	8	71646559	71646559	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:71646559G>A	ENST00000408926.3	+	5	1556	c.1022G>A	c.(1021-1023)gGg>gAg	p.G341E	XKR9_ENST00000520273.1_Intron|XKR9_ENST00000520030.1_Missense_Mutation_p.G341E	NM_001011720.1	NP_001011720.1	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related family, member 9	341						integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(4)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			GTTTATTATGGGAGTTTTCAC	0.313000													6	13					0	0	0.248553	0	0
PREX1	57580	broad.mit.edu	37	20	47249085	47249085	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:47249085G>A	ENST00000396220.1	-	34	4382	c.4360C>T	c.(4360-4362)Cgc>Tgc	p.R1454C	PREX1_ENST00000371941.3_Missense_Mutation_p.R1454C			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	1454					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CCCTCCAGGCGGGAGGGCAGC	0.647000													12	24					0	0	0.435327	0	0
CDC25B	994	broad.mit.edu	37	20	3779059	3779059	+	Splice_Site	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:3779059G>A	ENST00000245960.5	+	3	1026	c.328_splice	c.e3-1	p.G110_splice	CDC25B_ENST00000344256.6_Splice_Site_p.G46_splice|CDC25B_ENST00000467519.1_3'UTR|CDC25B_ENST00000439880.2_Splice_Site_p.G96_splice|CDC25B_ENST00000379598.5_Splice_Site_p.G46_splice|CDC25B_ENST00000340833.4_Splice_Site_p.G110_splice	NM_004358.3|NM_021872.2|NM_021873.2	NP_004349.1|NP_068658.1|NP_068659.1	P30305	MPIP2_HUMAN	cell division cycle 25B	110					cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			NS(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(1)	18						GTCCCCTCAGGTCTCTGCATG	0.463000													45	98					0	0	0.870114	0	0
MUC16	94025	broad.mit.edu	37	19	9084492	9084492	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:9084492G>A	ENST00000397910.4	-	1	7526	c.7323C>T	c.(7321-7323)tcC>tcT	p.S2441S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2441	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CACCCACATTGGAGCCCCCAT	0.498000													6	22					0	0	0.217242	0	0
ZNF30	90075	broad.mit.edu	37	19	35434914	35434914	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:35434914A>T	ENST00000439785.1	+	5	1491	c.1047A>T	c.(1045-1047)gaA>gaT	p.E349D	ZNF30_ENST00000426813.2_Missense_Mutation_p.E267D|ZNF30_ENST00000601142.1_Missense_Mutation_p.E348D|ZNF30_ENST00000601957.1_3'UTR|ZNF30_ENST00000303586.7_Missense_Mutation_p.E349D	NM_001099438.1	NP_001092908.1	P17039	ZNF30_HUMAN	zinc finger protein 30	348					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)	16	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		AATGTAAGGAATGTGGAAAGG	0.443000													6	44					0	0	0.248553	0	0
HACE1	57531	broad.mit.edu	37	6	105280966	105280966	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:105280966G>A	ENST00000262903.4	-	6	761	c.485C>T	c.(484-486)gCc>gTc	p.A162V	HACE1_ENST00000369125.2_Missense_Mutation_p.A162V|RP11-809N15.2_ENST00000422930.1_RNA	NM_020771.3	NP_065822.2	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	162					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity	p.A162V(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	44		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		CTGCCCCATGGCATCCTCAAC	0.468000													32	48					0	0	0.796494	0	0
SULT2B1	6820	broad.mit.edu	37	19	49102445	49102445	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:49102445G>A	ENST00000323090.4	+	6	1210	c.835G>A	c.(835-837)Gat>Aat	p.D279N	SULT2B1_ENST00000594274.1_3'UTR|SULT2B1_ENST00000201586.2_Missense_Mutation_p.D294N	NM_004605.2	NP_004596.2	O00204	ST2B1_HUMAN	sulfotransferase family, cytosolic, 2B, member 1	294					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|skin(2)|urinary_tract(1)	11		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000115)|all cancers(93;0.000147)|GBM - Glioblastoma multiforme(486;0.00707)|Epithelial(262;0.0178)		CGAAGCCTTCGATCGTGCCTA	0.667000													8	3					0	0	0.335167	0	0
CLDN6	9074	broad.mit.edu	37	16	3065827	3065827	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:3065827C>T	ENST00000396925.1	-	3	624	c.196G>A	c.(196-198)Gtg>Atg	p.V66M	CLDN6_ENST00000328796.4_Missense_Mutation_p.V66M|CLDN6_ENST00000572154.1_Intron			P56747	CLD6_HUMAN	claudin 6	66					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	10						GAGTCGTACACCTTGCACTGC	0.637000													46	16					0	0	0.870114	0	0
DDX31	64794	broad.mit.edu	37	9	135545422	135545422	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:135545422C>T	ENST00000372159.3	-	1	366	c.215G>A	c.(214-216)aGg>aAg	p.R72K	DDX31_ENST00000310532.2_Missense_Mutation_p.R72K|GTF3C4_ENST00000483873.2_5'UTR|DDX31_ENST00000480876.1_5'UTR|DDX31_ENST00000372153.1_Missense_Mutation_p.R72K|GTF3C4_ENST00000372146.4_5'UTR	NM_022779.7	NP_073616.6	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	72						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		GCCACCGCCCCTTCCGGGTCC	0.756000													3	0					0	0	0.150653	0	0
BAZ2A	11176	broad.mit.edu	37	12	57007849	57007849	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:57007849G>A	ENST00000179765.5	-	5	913	c.714C>T	c.(712-714)gtC>gtT	p.V238V	BAZ2A_ENST00000551812.1_Silent_p.V270V|BAZ2A_ENST00000549884.1_Silent_p.V268V|BAZ2A_ENST00000379441.3_Silent_p.V240V			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	270					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						TGGGGTCAGGGACCAGGACTG	0.488000													27	73					0	0	0.750413	0	0
MYH2	4620	broad.mit.edu	37	17	10442632	10442632	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:10442632C>T	ENST00000245503.5	-	14	1690	c.1306G>A	c.(1306-1308)Gag>Aag	p.E436K	MYH2_ENST00000397183.2_Missense_Mutation_p.E436K|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Missense_Mutation_p.E436K	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	436	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.E436*(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						AACATCTTCTCGTAGACGGCT	0.483000													35	130					0	0	0.847076	0	0
PKD1L1	168507	broad.mit.edu	37	7	47876654	47876654	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:47876654G>A	ENST00000289672.2	-	37	5858	c.5808C>T	c.(5806-5808)ttC>ttT	p.F1936F		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1936					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GCCAGACATGGAAATCCTCCA	0.552000													18	39					0	0	0.592651	0	0
SUGP1	57794	broad.mit.edu	37	19	19414819	19414819	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:19414819G>A	ENST00000334782.5	-	5	584	c.572C>T	c.(571-573)cCc>cTc	p.P191L	SUGP1_ENST00000585763.1_Intron|SUGP1_ENST00000247001.5_Intron			Q8IWZ8	SUGP1_HUMAN	SURP and G patch domain containing 1	114					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	22						CCATGACGAGGGGGGAGTCGG	0.572000													88	66					0	0	0.870114	0	0
KDR	3791	broad.mit.edu	37	4	55984957	55984957	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:55984957C>T	ENST00000263923.4	-	3	467	c.172G>A	c.(172-174)Gac>Aac	p.D58N		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	58	Ig-like C2-type 1.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CAGTCCAAGTCCCTCTGTCCC	0.438000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			29	14					0	0	0.804634	0	0
SLFN13	146857	broad.mit.edu	37	17	33771893	33771893	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:33771893C>T	ENST00000285013.6	-	3	1082	c.807G>A	c.(805-807)ttG>ttA	p.L269L	SLFN13_ENST00000526861.1_Silent_p.L269L|SLFN13_ENST00000360502.2_Intron|SLFN13_ENST00000542635.1_Silent_p.L269L|SLFN13_ENST00000534689.1_Intron|SLFN13_ENST00000533791.1_Silent_p.L269L	NM_144682.5	NP_653283.3	Q68D06	SLN13_HUMAN	schlafen family member 13	269						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TTACATTTTTCAAAGAGTCAG	0.403000													65	53					0	0	0.870114	0	0
FBP2	8789	broad.mit.edu	37	9	97333797	97333797	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:97333797T>C	ENST00000375337.3	-	4	580	c.514A>G	c.(514-516)Acc>Gcc	p.T172A		NM_003837.2	NP_003828.2	O00757	F16P2_HUMAN	fructose-1,6-bisphosphatase 2	172					fructose metabolic process|gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|metal ion binding			endometrium(1)|large_intestine(3)|lung(5)	9		Acute lymphoblastic leukemia(62;0.136)				GCCACCAGGGTTGCACTACCG	0.572000													32	14					0	0	0.819951	0	0
ITIH2	3698	broad.mit.edu	37	10	7768995	7768995	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr10:7768995G>A	ENST00000358415.4	+	10	1233	c.1067G>A	c.(1066-1068)cGa>cAa	p.R356Q	ITIH2_ENST00000379587.4_Missense_Mutation_p.R345Q	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	356	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						CAGAACATTCGAACTTGGAGA	0.403000													30	11					0	0	0.796494	0	0
SELT	51714	broad.mit.edu	37	3	150344871	150344871	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:150344871G>A	ENST00000471696.1	+	5	613	c.538G>A	c.(538-540)Gaa>Aaa	p.E180K	SELT_ENST00000477889.1_Missense_Mutation_p.E122K|SELT_ENST00000480740.1_Missense_Mutation_p.E122K|SELT_ENST00000485923.1_Missense_Mutation_p.E122K	NM_016275.3	NP_057359.2	P62341	SELT_HUMAN		180					cell redox homeostasis|selenocysteine incorporation		selenium binding							LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			TCTTGACAATGAAATGAAGCT	0.403000													53	79					0	0	0.870114	0	0
RALYL	138046	broad.mit.edu	37	8	85441693	85441693	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:85441693G>A	ENST00000521268.1	+	2	1242	c.137G>A	c.(136-138)gGa>gAa	p.G46E	RALYL_ENST00000522455.1_Missense_Mutation_p.G46E|RALYL_ENST00000517638.1_Missense_Mutation_p.G59E|RALYL_ENST00000518566.1_Missense_Mutation_p.G46E|RALYL_ENST00000521695.1_Missense_Mutation_p.G46E	NM_173848.5	NP_776247.3	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	46	RRM.						identical protein binding|nucleotide binding|RNA binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						TCAAAGTATGGAAAAATAGTT	0.418000													10	12					0	0	0.411799	0	0
ACTRT1	139741	broad.mit.edu	37	X	127186097	127186097	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:127186097C>T	ENST00000371124.3	-	1	285	c.89G>A	c.(88-90)gGa>gAa	p.G30E		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	30						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						ATGGCGGGGTCCAATCTCTCC	0.448000													17	15					0	0	0.557998	0	0
ZFP90	146198	broad.mit.edu	37	16	68597632	68597632	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:68597632C>T	ENST00000570495.1	+	5	1234	c.942C>T	c.(940-942)ctC>ctT	p.L314L	RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000563169.2_Silent_p.L314L|ZFP90_ENST00000398253.2_Silent_p.L314L			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	314					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		AGTGTAGTCTCTGTGGGAAAG	0.483000													28	12					0	0	0.750413	0	0
KCNC3	3748	broad.mit.edu	37	19	50823849	50823849	+	Splice_Site	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:50823849C>T	ENST00000376959.2	-	3	2334		c.e3+1		KCNC3_ENST00000474951.1_Splice_Site|KCNC3_ENST00000391818.2_Splice_Site|KCNC3_ENST00000477616.1_Splice_Site			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3						cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		GGGCACCTCACCTTTTCGGAT	0.672000													9	6					0	0	0.361761	0	0
BEND4	389206	broad.mit.edu	37	4	42145696	42145696	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:42145696G>A	ENST00000502486.1	-	3	1382	c.803C>T	c.(802-804)tCg>tTg	p.S268L	BEND4_ENST00000504360.1_Missense_Mutation_p.S264L	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	268										NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						ACTGGCTGACGAGGGGTTTGG	0.493000													13	6					0	0	0.479597	0	0
ESPL1	9700	broad.mit.edu	37	12	53683351	53683351	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:53683351C>T	ENST00000257934.4	+	22	5177	c.5086C>T	c.(5086-5088)Cag>Tag	p.Q1696*	ESPL1_ENST00000552462.1_Nonsense_Mutation_p.Q1696*	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	1696					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						GGAGAGTTTCCAGGAGCGCCT	0.602000													17	22					0	0	0.654019	0	0
HTR4	3360	broad.mit.edu	37	5	147900490	147900490	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:147900490G>A	ENST00000362016.2	-	6	707	c.544C>T	c.(544-546)Cat>Tat	p.H182Y	HTR4_ENST00000354217.2_Intron|HTR4_ENST00000517929.1_Intron|HTR4_ENST00000377888.3_Intron|HTR4_ENST00000314512.6_Intron|HTR4_ENST00000520514.1_Intron|HTR4_ENST00000521735.1_Intron|HTR4_ENST00000521530.1_Intron|HTR4_ENST00000360693.3_Intron			Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	169					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	CATACCGCATGAAAATCCTGG	0.448000													36	16					0	0	0.870114	0	0
TNXB	7148	broad.mit.edu	37	6	32052356	32052356	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:32052356C>T	ENST00000375244.3	-	8	3480	c.3279G>A	c.(3277-3279)gtG>gtA	p.V1093V	TNXB_ENST00000375247.2_Silent_p.V1093V			P22105	TENX_HUMAN	tenascin XB	1180	Fibronectin type-III 3.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TGTACTGGATCACGAAGGAGT	0.657000													10	23					0	0	0.435327	0	0
CDRT1	374286	broad.mit.edu	37	17	15519013	15519013	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:15519013G>A	ENST00000455584.2	-	8	1589	c.1546C>T	c.(1546-1548)Cct>Tct	p.P516S	CDRT1_ENST00000395906.3_Missense_Mutation_p.P206S																							TTGGACAAAGGAAGGGATGTG	0.488000													14	13					0	0	0.654019	0	0
MUC16	94025	broad.mit.edu	37	19	9082794	9082794	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:9082794G>A	ENST00000397910.4	-	1	9224	c.9021C>T	c.(9019-9021)acC>acT	p.T3007T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3008	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGCAAGAGAGGTCGATGTCA	0.488000													7	56					0	0	0.307466	0	0
MUC16	94025	broad.mit.edu	37	19	9086687	9086687	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:9086687C>T	ENST00000397910.4	-	1	5331	c.5128G>A	c.(5128-5130)Gaa>Aaa	p.E1710K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1710	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGACTCCTTCAGTAGTTGAC	0.488000													50	24					0	0	0.870114	0	0
ADAM7	8756	broad.mit.edu	37	8	24300035	24300035	+	Silent	SNP	G	G	A	rs146117431	by1000genomes	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:24300035G>A	ENST00000175238.6	+	2	185	c.102G>A	c.(100-102)aaG>aaA	p.K34K	RP11-624C23.1_ENST00000519689.1_RNA|ADAM7_ENST00000380789.1_Silent_p.K34K|ADAM7_ENST00000441335.2_Silent_p.K34K|RP11-624C23.1_ENST00000523578.1_RNA	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	34					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		GTCCTAAAAAGCTTCCTCTGA	0.393000													65	159					0	0	0.870114	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138418934	138418934	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:138418934G>A	ENST00000310018.2	-	16	1920	c.1638C>T	c.(1636-1638)atC>atT	p.I546I	ATP6V0A4_ENST00000393054.1_Silent_p.I546I|ATP6V0A4_ENST00000353492.4_Silent_p.I546I	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	546					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CAATTCCCAGGATCACCGACA	0.428000													20	25					0	0	0.624587	0	0
MUC2	4583	broad.mit.edu	37	11	1101046	1101046	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:1101046G>A	ENST00000441003.2	+	41	7472	c.7445G>A	c.(7444-7446)gGa>gAa	p.G2482E		NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4844						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CTGGAGGGTGGAAGTGGCATC	0.602000													15	7					0	0	0.500413	0	0
DSG1	1828	broad.mit.edu	37	18	28926037	28926037	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:28926037G>A	ENST00000257192.4	+	14	2188	c.1976G>A	c.(1975-1977)gGa>gAa	p.G659E	RP11-534N16.1_ENST00000578119.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA|DSG1_ENST00000462981.2_Missense_Mutation_p.G18E	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	659					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CTAACAGAGGGAGTTAAAACT	0.383000													16	27					0	0	0.520397	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39914450	39914450	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:39914450C>T	ENST00000425673.1	+	17	2915	c.2590C>T	c.(2590-2592)Ctg>Ttg	p.L864L	PLEKHG2_ENST00000409797.2_Intron|PLEKHG2_ENST00000458508.2_Silent_p.L834L|PLEKHG2_ENST00000409794.3_Silent_p.L893L|PLEKHG2_ENST00000378550.1_Intron			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	893					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GTCTGTCCCCCTGGGTCCTGC	0.567000													32	18					0	0	0.769981	0	0
TTN	7273	broad.mit.edu	37	2	179467100	179467100	+	Silent	SNP	C	C	T	rs62178963	by1000genomes	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:179467100C>T	ENST00000589042.1	-	283	55253	c.55029G>A	c.(55027-55029)agG>agA	p.R18343R	TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Silent_p.R9470R|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Silent_p.R15775R|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000591111.1_Silent_p.R16702R|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000460472.2_Silent_p.R9278R|TTN_ENST00000359218.5_Silent_p.R9403R|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16702	Fibronectin type-III 33.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTGTACTTCCTGAGCTCTT	0.413000													12	47					0	0	0.457914	0	0
WWTR1	25937	broad.mit.edu	37	3	149290664	149290664	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:149290664G>A	ENST00000465804.1	-	4	811	c.555C>T	c.(553-555)tcC>tcT	p.S185S	WWTR1_ENST00000360632.3_Silent_p.S185S|WWTR1_ENST00000467467.1_Silent_p.S185S	NM_001168278.1	NP_001161750.1	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	185					hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	23			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GATTTGGCTGGGATACTGCCA	0.468000			T	CAMTA1	epitheliod hemangioendothelioma								35	40					0	0	0.796494	0	0
EPHA7	2045	broad.mit.edu	37	6	93956529	93956529	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:93956529G>A	ENST00000369303.4	-	15	2891	c.2707C>T	c.(2707-2709)Ccc>Tcc	p.P903S		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	903			P -> S (in a metastatic melanoma sample; somatic mutation).			integral to plasma membrane	ATP binding|ephrin receptor activity	p.P903S(1)		NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GTTCCCAGGGGAGTTTTCAGA	0.403000													15	37					0	0	0.575678	0	0
DCC	1630	broad.mit.edu	37	18	51013265	51013265	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:51013265C>T	ENST00000442544.2	+	26	4451	c.3835C>T	c.(3835-3837)Ctc>Ttc	p.L1279F	DCC_ENST00000581580.1_Missense_Mutation_p.L914F|RP11-671P2.1_ENST00000582064.1_RNA	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1279					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GCAGTTCACTCTCCGGCCTGT	0.542000													44	65					0	0	0.870114	0	0
DZIP1	22873	broad.mit.edu	37	13	96239829	96239829	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr13:96239829C>T	ENST00000347108.3	-	18	2614	c.2182G>A	c.(2182-2184)Gaa>Aaa	p.E728K	DZIP1_ENST00000361396.2_Missense_Mutation_p.E709K|DZIP1_ENST00000376829.2_Missense_Mutation_p.E728K|DZIP1_ENST00000361156.3_Missense_Mutation_p.E709K			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	728					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TCCTCGATTTCGCTTCCCTCG	0.547000													88	30					0	0	0.870114	0	0
RYR3	6263	broad.mit.edu	37	15	33954484	33954484	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:33954484G>A	ENST00000389232.4	+	35	4823	c.4753G>A	c.(4753-4755)Gac>Aac	p.D1585N	RYR3_ENST00000415757.3_Missense_Mutation_p.D1585N	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1585	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGCCACGTGGACCTCTCCCA	0.612000													11	6					0	0	0.387290	0	0
HTR1B	3351	broad.mit.edu	37	6	78172692	78172692	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:78172692G>A	ENST00000369947.2	-	1	798	c.429C>T	c.(427-429)atC>atT	p.I143I		NM_000863.1	NP_000854.1	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	143					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(2)|upper_aerodigestive_tract(2)	25		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	GGTCCAGGGCGATGACACAGA	0.617000													11	23					0	0	0.411799	0	0
WDR75	84128	broad.mit.edu	37	2	190334870	190334870	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:190334870C>T	ENST00000314761.4	+	17	1948	c.1888C>T	c.(1888-1890)Cag>Tag	p.Q630*		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	630						nucleolus				breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			AGAGAAAGTCCAGTGGGGAGT	0.398000													47	105					0	0	0.870114	0	0
BAZ2A	11176	broad.mit.edu	37	12	57011238	57011238	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:57011238G>A	ENST00000179765.5	-	2	276	c.77C>T	c.(76-78)tCc>tTc	p.S26F	BAZ2A_ENST00000551812.1_Missense_Mutation_p.S28F|BAZ2A_ENST00000549884.1_Missense_Mutation_p.S26F|BAZ2A_ENST00000379441.3_Missense_Mutation_p.S28F			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	28					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						CTCCCCTGAGGAAGGAGAGGG	0.577000													7	9					0	0	0.248553	0	0
MPP2	4355	broad.mit.edu	37	17	41958903	41958903	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:41958903A>C	ENST00000269095.4	-	7	1040	c.736T>G	c.(736-738)Tgc>Ggc	p.C246G	MPP2_ENST00000523501.1_Missense_Mutation_p.C235G|MPP2_ENST00000518766.1_Missense_Mutation_p.C291G|MPP2_ENST00000520305.1_Missense_Mutation_p.C107G|MPP2_ENST00000461854.1_Missense_Mutation_p.C270G|MPP2_ENST00000377184.3_Missense_Mutation_p.C263G|MPP2_ENST00000536246.1_Missense_Mutation_p.C235G	NM_001278370.1|NM_001278381.1|NM_005374.3	NP_001265299.1|NP_001265310.1|NP_005365.3	Q14168	MPP2_HUMAN	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	270					signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|liver(1)|lung(4)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		GCTTCCTTGCAGGGGATGAGG	0.597000													16	44					0	0	0.539581	0	0
PLEKHO1	51177	broad.mit.edu	37	1	150129151	150129151	+	Missense_Mutation	SNP	C	C	T	rs141386276		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:150129151C>T	ENST00000369124.4	+	4	643	c.365C>T	c.(364-366)tCg>tTg	p.S122L	PLEKHO1_ENST00000479194.1_3'UTR|PLEKHO1_ENST00000369126.1_5'UTR|PLEKHO1_ENST00000025469.6_Missense_Mutation_p.S122L	NM_016274.4	NP_057358.2	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O member 1	122	PH.					cytoplasm|nucleus|plasma membrane				breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|skin(2)	22	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAGAAGGAATCGTGGATCAAT	0.567000													88	28					0	0	0.870114	0	0
OR6C74	254783	broad.mit.edu	37	12	55641256	55641256	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:55641256G>A	ENST00000343870.4	+	1	275	c.185G>A	c.(184-186)cGa>cAa	p.R62Q		NM_001005490.1	NP_001005490.1	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C, member 74	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R62Q(1)		central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	12						TTCTTCCTCCGAAATTTCTCA	0.383000													54	70					0	0	0.870114	0	0
OR9A4	130075	broad.mit.edu	37	7	141619006	141619006	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:141619006G>A	ENST00000548136.1	+	1	390	c.331G>A	c.(331-333)Gag>Aag	p.E111K	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					GGGGACAACAGAGTTCGCATT	0.493000													58	71					0	0	0.870114	0	0
ANK3	288	broad.mit.edu	37	10	61834248	61834248	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr10:61834248C>T	ENST00000280772.1	-	37	6582	c.6391G>A	c.(6391-6393)Gaa>Aaa	p.E2131K	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2131					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTTCTTGTTTCAAAGCCACTG	0.423000													17	16					0	0	0.592651	0	0
HYDIN	54768	broad.mit.edu	37	16	70989293	70989293	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:70989293C>T	ENST00000393567.2	-	40	6451	c.6301G>A	c.(6301-6303)Gaa>Aaa	p.E2101K		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2101										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TCCTCTCCTTCCTTCACGGAC	0.572000													6	35					0	0	0.248553	0	0
DNAH8	1769	broad.mit.edu	37	6	38997949	38997949	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:38997949G>T	ENST00000359357.3	+	91	13508	c.13254G>T	c.(13252-13254)atG>atT	p.M4418I	DNAH8_ENST00000441566.1_Missense_Mutation_p.M4382I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GGAAGCTCATGGAATCCACCC	0.502000											OREG0017409	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	19					4.96729e-08	4.99976e-08	0.575678	1	0
SERPINB4	6318	broad.mit.edu	37	18	61310800	61310800	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:61310800G>A	ENST00000341074.5	-	2	127	c.12C>T	c.(10-12)ctC>ctT	p.L4L	SERPINB4_ENST00000356424.6_Silent_p.L4L	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						TGGCTTCACTGAGTGAATTCA	0.388000													53	91					0	0	0.870114	0	0
DNMBP	23268	broad.mit.edu	37	10	101639994	101639994	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr10:101639994G>A	ENST00000342239.3	-	16	4285	c.4194C>T	c.(4192-4194)ttC>ttT	p.F1398F	DNMBP_ENST00000543621.1_Silent_p.F620F|DNMBP_ENST00000324109.4_Silent_p.F1374F|DNMBP_ENST00000540316.1_Silent_p.F310F			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1374	Ser-rich.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TCTGGCGTGGGAACCTGGGGG	0.607000													29	15					0	0	0.779181	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12837292	12837292	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:12837292C>T	ENST00000357726.4	+	3	1029	c.1002C>T	c.(1000-1002)ttC>ttT	p.F334F		NM_001080830.1	NP_001074299.1	O95522	PRA12_HUMAN	PRAME family member 12	334										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|urinary_tract(1)	23	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGACCCATTTCAGTCCTGAGC	0.572000													52	8					0	0	0.870114	0	0
MEP1A	4224	broad.mit.edu	37	6	46787370	46787370	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:46787370G>A	ENST00000230588.4	+	7	494	c.485G>A	c.(484-486)gGa>gAa	p.G162E		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	162	Metalloprotease.			G -> V (in Ref. 2; AAL85339).	digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			CATGCTTTGGGATTTTACCAC	0.483000													41	106					0	0	0.870114	0	0
CD96	10225	broad.mit.edu	37	3	111319573	111319573	+	Splice_Site	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:111319573G>A	ENST00000352690.4	+	7	1139	c.898_splice	c.e7-1	p.G300_splice	CD96_ENST00000438817.2_Splice_Site_p.G300_splice|CD96_ENST00000283285.5_Splice_Site_p.G316_splice	NM_005816.4	NP_005807.1	P40200	TACT_HUMAN	CD96 molecule	316	Ig-like C2-type.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(4)|liver(2)|lung(14)|skin(5)	35						TGTCTGGCAGGAATATATATT	0.363000									Opitz Trigonocephaly syndrome				16	44					0	0	0.624587	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111075	7111075	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:7111075G>A	ENST00000306904.5	+	1	911	c.724G>A	c.(724-726)Gat>Aat	p.D242N		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	242	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CACCCACCGCGATTACGGCCA	0.657000													13	5					0	0	0.520397	0	0
SLC26A3	1811	broad.mit.edu	37	7	107408083	107408083	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:107408083C>T	ENST00000340010.5	-	20	2396	c.2212G>A	c.(2212-2214)Gat>Aat	p.D738N	SLC26A3_ENST00000422236.2_Missense_Mutation_p.D625N	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	738					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						ATTTTTCCATCTTTTTCCTGA	0.333000													15	14					0	0	0.479597	0	0
TADA2B	93624	broad.mit.edu	37	4	7056214	7056214	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:7056214C>T	ENST00000310074.7	+	2	885	c.696C>T	c.(694-696)ttC>ttT	p.F232F	TADA2B_ENST00000515646.1_Silent_p.F140F|TADA2B_ENST00000512388.1_Silent_p.F157F	NM_152293.2	NP_689506.2	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2B	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding			breast(3)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	18						TGCCAGCCTTCCTGGGGAAGG	0.582000													41	17					0	0	0.859065	0	0
TAMM41	132001	broad.mit.edu	37	3	11885563	11885563	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:11885563G>A	ENST00000444133.2	-	2	400	c.258C>T	c.(256-258)tcC>tcT	p.S86S	TAMM41_ENST00000455809.1_Silent_p.S86S|TAMM41_ENST00000273037.5_Silent_p.S86S			Q96BW9	MMP37_HUMAN	TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae)	86					protein import into mitochondrial matrix	extrinsic to mitochondrial inner membrane											TATTCTGGATGGACGTGATAA	0.418000													15	29					0	0	0.500413	0	0
OR9A4	130075	broad.mit.edu	37	7	141619367	141619367	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:141619367C>T	ENST00000548136.1	+	1	751	c.692C>T	c.(691-693)tCc>tTc	p.S231F	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					ATCCCGTCATCCTCTGGCCGG	0.478000													51	66					0	0	0.870114	0	0
MARCH7	64844	broad.mit.edu	37	2	160605239	160605239	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:160605239C>T	ENST00000259050.3	+	5	1560	c.1438C>T	c.(1438-1440)Cct>Tct	p.P480S	MARCH7_ENST00000409175.1_Missense_Mutation_p.P480S|MARCH7_ENST00000409591.1_Missense_Mutation_p.P442S|MARCH7_ENST00000539065.1_Missense_Mutation_p.P424S	NM_022826.2	NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase	480							ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						AGGGATTCTTCCTGGTTCCTT	0.463000													80	244					0	0	0.870114	0	0
PLCD3	113026	broad.mit.edu	37	17	43196225	43196225	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:43196225G>A	ENST00000322765.5	-	5	983	c.870C>T	c.(868-870)gcC>gcT	p.A290A	PLCD3_ENST00000540511.1_5'UTR	NM_133373.3	NP_588614.1	Q8N3E9	PLCD3_HUMAN	phospholipase C, delta 3	290					intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	17					Phosphatidylserine(DB00144)	GCTGGGCGCGGGCCAGTGTGG	0.647000													7	10					0	0	0.335167	0	0
OR6C6	283365	broad.mit.edu	37	12	55688524	55688524	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:55688524C>T	ENST00000358433.2	-	1	492	c.493G>A	c.(493-495)Gat>Aat	p.D165N		NM_001005493.1	NP_001005493.1	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C, member 6	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						GCACAAAAATCCAGCTTGAGT	0.403000													28	38					0	0	0.769981	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501321	90501321	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:90501321C>T	ENST00000325643.5	+	4	1985	c.1919C>T	c.(1918-1920)tCc>tTc	p.S640F		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1									p.S640Y(1)									CAGGAGCAGTCCTGTGGCCCT	0.632000													16	11					0	0	0.479597	0	0
SCN11A	11280	broad.mit.edu	37	3	38951590	38951590	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:38951590C>T	ENST00000302328.3	-	8	1266	c.1068G>A	c.(1066-1068)atG>atA	p.M356I	SCN11A_ENST00000456224.3_Missense_Mutation_p.M356I|SCN11A_ENST00000450244.1_Missense_Mutation_p.M356I|SCN11A_ENST00000444237.2_Missense_Mutation_p.M356I	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	356					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AATCTTGGGTCATCAGCCGGA	0.403000													17	29					0	0	0.608945	0	0
SEMA4D	10507	broad.mit.edu	37	9	91993689	91993689	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:91993689G>A	ENST00000450295.1	-	16	3295	c.2519C>T	c.(2518-2520)tCt>tTt	p.S840F	SEMA4D_ENST00000422704.2_Missense_Mutation_p.S840F|SEMA4D_ENST00000356444.2_Missense_Mutation_p.S840F|SEMA4D_ENST00000343780.4_Intron|SEMA4D_ENST00000339861.4_Intron|SEMA4D_ENST00000438547.2_Missense_Mutation_p.S840F|SEMA4D_ENST00000455551.2_Intron|SEMA4D_ENST00000420987.1_Intron			Q92854	SEM4D_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	840					anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(8)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34						GTCCCTGGCAGAAAGGTCGTC	0.602000													25	10					0	0	0.681144	0	0
IGLV3-12	28802	broad.mit.edu	37	22	23114853	23114853	+	RNA	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr22:23114853G>A	ENST00000390313.2	+	0	134																											ATCACCTGTGGGGGAAACAAC	0.527000													8	26					0	0	0.278610	0	0
EMILIN3	90187	broad.mit.edu	37	20	39990079	39990079	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:39990079C>T	ENST00000332312.3	-	4	2322	c.2130G>A	c.(2128-2130)ctG>ctA	p.L710L		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	710						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				GCAAGCTGTCCAGGCCCGCGG	0.647000													3	10					0	0	0.150653	0	0
BSN	8927	broad.mit.edu	37	3	49692966	49692966	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:49692966G>A	ENST00000296452.4	+	5	6091	c.5977G>A	c.(5977-5979)Ggc>Agc	p.G1993S		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1993					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGCTGAGGCTGGCCTCAACTA	0.622000													19	53					0	0	0.592651	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891723	18891723	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:18891723G>A	ENST00000317658.3	+	1	679	c.521G>A	c.(520-522)tGg>tAg	p.W174*		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	174					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				AAATCTAAATGGATTTTCCAA	0.383000													18	47					0	0	0.592651	0	0
PLGLA	285189	broad.mit.edu	37	2	107002800	107002800	+	RNA	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:107002800G>A	ENST00000484422.1	+	0	32																											GTGTCACTAAGAAGCAGCTGG	0.498000													41	128					0	0	0.859065	0	0
TJP1	7082	broad.mit.edu	37	15	30009029	30009029	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:30009029G>A	ENST00000346128.6	-	23	4462	c.3988C>T	c.(3988-3990)Caa>Taa	p.Q1330*	TJP1_ENST00000545208.2_Nonsense_Mutation_p.Q1250*|TJP1_ENST00000400011.2_Nonsense_Mutation_p.Q1254*|TJP1_ENST00000356107.6_Nonsense_Mutation_p.Q1330*	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	1330					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TGAGGTTTTTGAGGTTCTGGG	0.343000													33	27					0	0	0.853193	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192551	132192551	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:132192551T>C	ENST00000359827.3	-	2	1864	c.902A>G	c.(901-903)gAg>gGg	p.E301G	PLXNA4_ENST00000378539.5_Missense_Mutation_p.E301G|PLXNA4_ENST00000423507.2_Missense_Mutation_p.E301G|PLXNA4_ENST00000321063.4_Missense_Mutation_p.E301G			Q9HCM2	PLXA4_HUMAN	plexin A4	301	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CCCACTGCGCTCACAGCCAAT	0.597000													21	37					0	0	0.639603	0	0
IL10RA	3587	broad.mit.edu	37	11	117869501	117869501	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:117869501C>T	ENST00000227752.3	+	7	1002	c.882C>T	c.(880-882)caC>caT	p.H294H	IL10RA_ENST00000545409.1_Silent_p.H145H|IL10RA_ENST00000541785.1_Silent_p.H274H|IL10RA_ENST00000533700.1_3'UTR	NM_001558.3	NP_001549.2	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha	294						integral to membrane|plasma membrane	interleukin-10 receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		ACACCATCCACCCGCTTGATG	0.582000													25	11					0	0	0.706142	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138577	126138577	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:126138577C>T	ENST00000299308.3	+	9	2566	c.2558C>T	c.(2557-2559)cCc>cTc	p.P853L	TMEM132B_ENST00000535886.1_Missense_Mutation_p.P365L	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	853						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CCCCAGTCTCCCATGGAAGGG	0.522000													11	14					0	0	0.435327	0	0
OAS1	4938	broad.mit.edu	37	12	113357260	113357260	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:113357260G>A	ENST00000202917.5	+	6	1368	c.1105G>A	c.(1105-1107)Gga>Aga	p.G369R	OAS1_ENST00000445409.2_Intron|RP1-71H24.1_ENST00000552784.1_RNA|OAS1_ENST00000551241.1_Intron	NM_016816.2	NP_058132.2	P00973	OAS1_HUMAN	2'-5'-oligoadenylate synthetase 1, 40/46kDa	369					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)|skin(1)	16						TGGTTACATTGGAACACATGA	0.512000													24	60					0	0	0.740014	0	0
KERA	11081	broad.mit.edu	37	12	91449844	91449844	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:91449844C>T	ENST00000266719.3	-	2	462	c.215G>A	c.(214-216)aGa>aAa	p.R72K		NM_007035.3	NP_008966.1	O60938	KERA_HUMAN	keratocan	72					response to stimulus|visual perception	proteinaceous extracellular matrix		p.R72I(1)		breast(2)|large_intestine(8)|lung(5)|prostate(2)|skin(2)	19						ATACCAAATTCTTGAAGGAAT	0.383000													11	29					0	0	0.411799	0	0
CADM2	253559	broad.mit.edu	37	3	85984971	85984971	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:85984971C>T	ENST00000383699.3	+	7	1382	c.755C>T	c.(754-756)cCt>cTt	p.P252L	CADM2_ENST00000407528.2_Missense_Mutation_p.P243L|CADM2_ENST00000405615.2_Missense_Mutation_p.P245L	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	243	Ig-like C2-type 2.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GAAGGACAGCCTTTAATTTTG	0.303000													40	67					0	0	0.870114	0	0
HDHD2	84064	broad.mit.edu	37	18	44635148	44635148	+	Nonsense_Mutation	SNP	G	G	A	rs141476363	byFrequency	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:44635148G>A	ENST00000300605.6	-	7	837	c.685C>T	c.(685-687)Cga>Tga	p.R229*	HDHD2_ENST00000587841.1_5'UTR	NM_032124.4	NP_115500.1	Q9H0R4	HDHD2_HUMAN	haloacid dehalogenase-like hydrolase domain containing 2	229							hydrolase activity			kidney(2)|large_intestine(2)|lung(1)|skin(1)	6						TCTGATGCTCGATATTTCCCT	0.443000													11	15					0	0	0.411799	0	0
ZNF728	388523	broad.mit.edu	37	19	23159858	23159858	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:23159858G>A	ENST00000594710.1	-	4	426	c.281C>T	c.(280-282)tCt>tTt	p.S94F		NM_001267716.1	NP_001254645.1			zinc finger protein 728																		TTTTTGGAAAGAATCTTCTCT	0.323000													4	2					0	0	0.217242	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95481655	95481655	+	RNA	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:95481655C>T	ENST00000432432.2	-	0	1705					NR_040113.1																						TGTCATTTTTCATTGTACATA	0.299000													29	43					0	0	0.740014	0	0
TTN	7273	broad.mit.edu	37	2	179441491	179441491	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:179441491C>T	ENST00000589042.1	-	325	69704	c.69480G>A	c.(69478-69480)tgG>tgA	p.W23160*	TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.W14287*|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.W20592*|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.W21519*|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.W14095*|TTN_ENST00000359218.5_Nonsense_Mutation_p.W14220*|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21519	Ig-like 118.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGCCTTTTCCAGCTGACAG	0.448000													9	41					0	0	0.335167	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971029	21971029	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:21971029C>T	ENST00000304494.5	-	2	599	c.329G>A	c.(328-330)tGg>tAg	p.W110*	CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.W110*|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.W59*|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.W110*|CDKN2A_ENST00000361570.3_Silent_p.L165L|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000579755.1_Silent_p.L124L|CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.W59*|CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.W110*|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.W59*|CDKN2A_ENST00000530628.2_Silent_p.L124L|CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.W59*|CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.W59*	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	110					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.W110*(13)|p.L165L(2)|p.H83fs*2(2)|p.D105fs*8(1)|p.0(1)|p.A68fs*3(1)|p.R107fs*33(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CAGACGGCCCCAGGCATCGCG	0.731000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			25	8					0	0	0.706142	0	0
GPR139	124274	broad.mit.edu	37	16	20043682	20043682	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:20043682C>T	ENST00000570682.1	-	2	737	c.437G>A	c.(436-438)cGg>cAg	p.R146Q		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	146						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						AATGACTTTCCGGGTGCGGGC	0.512000													94	44					0	0	0.870114	0	0
KCNB2	9312	broad.mit.edu	37	8	73480322	73480322	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:73480322C>T	ENST00000523207.1	+	2	941	c.353C>T	c.(352-354)tCg>tTg	p.S118L		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	118					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding	p.S118L(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			TGTGCACTTTCGTTTGGCCAA	0.423000													24	29					0	0	0.693898	0	0
SUGP2	10147	broad.mit.edu	37	19	19120938	19120938	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:19120938G>A	ENST00000601879.1	-	5	2361	c.2064C>T	c.(2062-2064)ctC>ctT	p.L688L	SUGP2_ENST00000456085.2_Silent_p.L457L|SUGP2_ENST00000337018.6_Silent_p.L688L|SUGP2_ENST00000452918.2_Silent_p.L688L|SUGP2_ENST00000600377.1_Silent_p.L702L			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	688					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						TCCAGCCCCGGAGCCCTTGAG	0.667000													36	27					0	0	0.847076	0	0
CNTN6	27255	broad.mit.edu	37	3	1424750	1424750	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:1424750G>A	ENST00000446702.2	+	18	2918	c.2291G>A	c.(2290-2292)aGa>aAa	p.R764K	CNTN6_ENST00000350110.2_Missense_Mutation_p.R764K|CNTN6_ENST00000539053.1_Missense_Mutation_p.R692K			Q9UQ52	CNTN6_HUMAN	contactin 6	764	Fibronectin type-III 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane		p.R764T(1)		breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TTTGTCTACAGAAATGAAAGC	0.458000													39	48					0	0	0.870114	0	0
MMP12	4321	broad.mit.edu	37	11	102738082	102738082	+	RNA	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:102738082G>A	ENST00000532855.1	-	0	925							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	AGCTGGTTCTGAATTGTCAGG	0.398000													10	2					0	0	0.361761	0	0
SNHG23	100507242	broad.mit.edu	37	14	101423536	101423536	+	RNA	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:101423536C>T	ENST00000556637.1	+	0	464				SNORD114-6_ENST00000364393.1_RNA																							GCGTATAAATCATATTTGGTG	0.313000													9	23					0	0	0.361761	0	0
NLRP4	147945	broad.mit.edu	37	19	56373457	56373457	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:56373457C>T	ENST00000301295.6	+	5	2540	c.2118C>T	c.(2116-2118)ctC>ctT	p.L706L	NLRP4_ENST00000346986.5_Silent_p.L706L|NLRP4_ENST00000587891.1_Silent_p.L631L	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	706							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TCACGAAACTCTCTCGTGATG	0.468000													30	18					0	0	0.769981	0	0
GALNT13	114805	broad.mit.edu	37	2	155099272	155099272	+	Silent	SNP	T	T	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:155099272T>A	ENST00000392825.3	+	6	1107	c.540T>A	c.(538-540)atT>atA	p.I180I	GALNT13_ENST00000409237.1_Silent_p.I180I	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	180	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						TAAAAATTATTAGGATGGAAG	0.358000													17	13					0	0	0.608945	0	0
RXFP2	122042	broad.mit.edu	37	13	32376374	32376374	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr13:32376374G>A	ENST00000298386.2	+	18	2168	c.2097G>A	c.(2095-2097)aaG>aaA	p.K699K	RXFP2_ENST00000380314.1_Silent_p.K675K	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	699						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		ACTTTTTTAAGGACAAGTTGA	0.353000													19	14					0	0	0.557998	0	0
TENM3	55714	broad.mit.edu	37	4	183594241	183594241	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:183594241C>T	ENST00000511685.1	+	7	1318	c.1195C>T	c.(1195-1197)Cct>Tct	p.P399S	TENM3_ENST00000406950.2_Missense_Mutation_p.P399S					teneurin transmembrane protein 3																		TCAAGAGATTCCTCCCGGGAT	0.403000													6	1					0	0	0.217242	0	0
GRHL2	79977	broad.mit.edu	37	8	102505011	102505011	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:102505011C>T	ENST00000251808.3	+	1	352	c.14C>T	c.(13-15)tCg>tTg	p.S5L	GRHL2_ENST00000395927.1_5'UTR	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	5	Transcription activation.					cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			TCACAAGAGTCGGACAAGTAA	0.473000													22	54					0	0	0.693898	0	0
TDGF1P3	6998	broad.mit.edu	37	X	109764525	109764525	+	RNA	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:109764525G>A	ENST00000602699.1	+	0	986					NR_002718.2																						CCCAGGAGGAGCCTGCAATTC	0.572000													3	12					0	0	0.184627	0	0
TOP3A	7156	broad.mit.edu	37	17	18183895	18183895	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:18183895C>T	ENST00000321105.5	-	17	2313	c.2099G>A	c.(2098-2100)aGg>aAg	p.R700K	TOP3A_ENST00000542570.1_Missense_Mutation_p.R605K|TOP3A_ENST00000540524.1_Missense_Mutation_p.R230K	NM_004618.3	NP_004609.1	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	700					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(2)|urinary_tract(1)	36						ACTGCTGTCCCTGCTGGCCTC	0.582000													6	30					0	0	0.278610	0	0
KIF17	57576	broad.mit.edu	37	1	20992747	20992747	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:20992747C>T	ENST00000247986.2	-	14	3181	c.2871G>A	c.(2869-2871)cgG>cgA	p.R957R	KIF17_ENST00000375044.1_Silent_p.R857R|KIF17_ENST00000400463.3_Silent_p.R956R|KIF17_ENST00000490034.1_5'UTR			Q9P2E2	KIF17_HUMAN	kinesin family member 17	957				R -> W (in Ref. 1; AAR33039 and 4; BAA92643).	microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TCTGGCTGGCCCGCTTAGATC	0.597000													65	22					0	0	0.870114	0	0
GRIN2A	2903	broad.mit.edu	37	16	9934839	9934839	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:9934839T>A	ENST00000396573.2	-	7	1760	c.1451A>T	c.(1450-1452)aAg>aTg	p.K484M	GRIN2A_ENST00000562109.1_Missense_Mutation_p.K484M|GRIN2A_ENST00000535259.1_Missense_Mutation_p.K327M|GRIN2A_ENST00000396575.2_Missense_Mutation_p.K484M|GRIN2A_ENST00000330684.3_Missense_Mutation_p.K484M|GRIN2A_ENST00000404927.2_Missense_Mutation_p.K484M	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	484					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTTGCCATGCTTCCCATTGGT	0.433000													64	35					0	0	0.870114	0	0
FARSB	10056	broad.mit.edu	37	2	223507586	223507586	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:223507586G>A	ENST00000281828.6	-	3	516	c.253C>T	c.(253-255)Cag>Tag	p.Q85*	FARSB_ENST00000536361.1_5'UTR	NM_005687.3	NP_005678.3	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	85					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	24		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	TTGAAGACCTGAAGTCCTCGA	0.393000													11	36					0	0	0.479597	0	0
CWC27	10283	broad.mit.edu	37	5	64079668	64079668	+	Silent	SNP	A	A	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:64079668A>G	ENST00000508024.1	+	4	459	c.258A>G	c.(256-258)gaA>gaG	p.E86E	CWC27_ENST00000381070.3_Silent_p.E86E			Q6UX04	CWC27_HUMAN	CWC27 spliceosome-associated protein homolog (S. cerevisiae)	86	PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(5)|prostate(1)	21						TTCAGGATGAATTTCATTCAC	0.413000													94	36					0	0	0.870114	0	0
YIF1B	90522	broad.mit.edu	37	19	38798128	38798128	+	Silent	SNP	G	G	A	rs146100643	byFrequency	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:38798128G>A	ENST00000392124.3	-	6	950	c.636C>T	c.(634-636)ttC>ttT	p.F212F	YIF1B_ENST00000592694.1_Silent_p.F212F|YIF1B_ENST00000592246.1_Silent_p.F177F|YIF1B_ENST00000591784.1_Silent_p.F212F|YIF1B_ENST00000329420.8_Silent_p.F228F|YIF1B_ENST00000339413.6_Silent_p.F243F|YIF1B_ENST00000337679.8_Silent_p.F240F|YIF1B_ENST00000591755.1_Silent_p.F240F	NM_033557.3	NP_291035.1	Q5BJH7	YIF1B_HUMAN	Yip1 interacting factor homolog B (S. cerevisiae)	243						integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|prostate(1)	10	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CAATCTTCCCGAAGAGCAGGC	0.647000													3	33					0	0	0.150653	0	0
SPINT1	6692	broad.mit.edu	37	15	41146659	41146659	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:41146659C>T	ENST00000344051.4	+	7	1287	c.1053C>T	c.(1051-1053)ttC>ttT	p.F351F	SPINT1_ENST00000431806.1_Silent_p.F335F|SPINT1_ENST00000562057.1_Silent_p.F335F			O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	351	LDL-receptor class A.					extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	16		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		TCGACAGTTTCCTGGAGTGTG	0.622000													24	24					0	0	0.740014	0	0
USH1C	10083	broad.mit.edu	37	11	17547943	17547943	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:17547943C>T	ENST00000005226.7	-	8	624	c.625G>A	c.(625-627)Gag>Aag	p.E209K	USH1C_ENST00000527020.1_Missense_Mutation_p.E209K|USH1C_ENST00000527720.1_Missense_Mutation_p.E178K|USH1C_ENST00000318024.4_Missense_Mutation_p.E209K	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	209					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						ACCTTCTTCTCCTTGTTTTCC	0.612000													11	7					0	0	0.435327	0	0
ZFAT	57623	broad.mit.edu	37	8	135614561	135614561	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:135614561G>A	ENST00000520727.1	-	7	1664	c.1365C>T	c.(1363-1365)ttC>ttT	p.F455F	ZFAT_ENST00000377838.3_Silent_p.F467F|ZFAT_ENST00000520356.1_Silent_p.F455F|ZFAT_ENST00000520214.1_Silent_p.F455F|ZFAT_ENST00000429442.2_Silent_p.F455F|ZFAT_ENST00000523399.1_Silent_p.F405F	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	467					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TGGAGCTGACGAACTTCTTGC	0.607000													10	27					0	0	0.435327	0	0
SH3TC1	54436	broad.mit.edu	37	4	8221094	8221094	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:8221094C>T	ENST00000539824.1	+	9	1095	c.721C>T	c.(721-723)Cag>Tag	p.Q241*	SH3TC1_ENST00000245105.3_Nonsense_Mutation_p.Q317*			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	317							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						GGCAGACTTCCAGGGCTCGGG	0.677000													20	33					0	0	0.693898	0	0
SMARCA2	6595	broad.mit.edu	37	9	2086993	2086993	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:2086993C>T	ENST00000382203.1	+	18	2900	c.2691C>T	c.(2689-2691)ttC>ttT	p.F897F	SMARCA2_ENST00000357248.2_Silent_p.F897F|SMARCA2_ENST00000382194.1_Silent_p.F897F|SMARCA2_ENST00000349721.2_Silent_p.F897F			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	897	Helicase ATP-binding.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		TCCTCAACTTCCTCCTCCCAA	0.498000													29	20					0	0	0.729181	0	0
CUL5	8065	broad.mit.edu	37	11	107920793	107920793	+	Splice_Site	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:107920793G>A	ENST00000393094.2	+	4	1027	c.411_splice	c.e4+1	p.K137_splice		NM_003478.3	NP_003469.2	Q93034	CUL5_HUMAN	cullin 5	137					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		TTGTTCGAAAGGTAAGACTAT	0.313000													25	8					0	0	0.779181	0	0
TECPR1	25851	broad.mit.edu	37	7	97874278	97874278	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:97874278C>T	ENST00000447648.2	-	4	626	c.327G>A	c.(325-327)gtG>gtA	p.V109V	TECPR1_ENST00000379795.3_Silent_p.V109V|TECPR1_ENST00000542604.1_Silent_p.V30V			Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	109						integral to membrane	protein binding			central_nervous_system(2)|endometrium(8)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AGGGCAGTGCCACCCTGTCCA	0.622000													20	29					0	0	0.654019	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													3	25					0	0	0.115264	0	0
FIBCD1	84929	broad.mit.edu	37	9	133787192	133787192	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:133787192C>T	ENST00000372338.4	-	5	1175	c.933G>A	c.(931-933)ggG>ggA	p.G311G	FIBCD1_ENST00000253018.4_Silent_p.G153G|FIBCD1_ENST00000448616.1_Silent_p.G311G|FIBCD1_ENST00000372337.2_Silent_p.G153G	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	311	Fibrinogen C-terminal.				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		GCCAGTGCTCCCCGGTGAGCC	0.662000													6	2					0	0	0.278610	0	0
DMC1	11144	broad.mit.edu	37	22	38934315	38934315	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr22:38934315G>A	ENST00000216024.2	-	11	1036	c.760C>T	c.(760-762)Caa>Taa	p.Q254*	DMC1_ENST00000428462.2_Nonsense_Mutation_p.Q199*	NM_007068.2	NP_008999.2	Q14565	DMC1_HUMAN	DNA meiotic recombinase 1	254					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11	Melanoma(58;0.0286)					GAGATTTTTTGGAGTCGTGAC	0.413000								Homologous recombination					20	36					0	0	0.693898	0	0
DSCAM	1826	broad.mit.edu	37	21	41725649	41725649	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr21:41725649G>A	ENST00000400454.1	-	5	1154	c.677C>T	c.(676-678)tCc>tTc	p.S226F		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	226	Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ATCCAGTATGGATGGGGCTGA	0.512000													5	10					0	0	0.217242	0	0
FSD1	79187	broad.mit.edu	37	19	4311969	4311969	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:4311969C>T	ENST00000221856.6	+	7	768	c.621C>T	c.(619-621)ttC>ttT	p.F207F	FSD1_ENST00000597590.1_Silent_p.F207F|FSD1_ENST00000598010.1_3'UTR	NM_024333.2	NP_077309.1	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing 1	207	Fibronectin type-III.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		GGACCAACTTCGAGGGCCCGC	0.622000													18	11					0	0	0.557998	0	0
FOXN1	8456	broad.mit.edu	37	17	26857782	26857782	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:26857782G>A	ENST00000226247.2	+	5	875	c.846G>A	c.(844-846)atG>atA	p.M282I	FOXN1_ENST00000579795.1_Missense_Mutation_p.M282I	NM_003593.2	NP_003584.2	O15353	FOXN1_HUMAN	forkhead box N1	282					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Lung NSC(42;0.00431)					TCATCTTCATGGCCCTTAAGA	0.537000													11	29					0	0	0.479597	0	0
PAOX	196743	broad.mit.edu	37	10	135195147	135195147	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr10:135195147C>T	ENST00000278060.5	+	3	935	c.852C>T	c.(850-852)atC>atT	p.I284I	PAOX_ENST00000368539.4_3'UTR|PAOX_ENST00000357296.3_Silent_p.I284I|PAOX_ENST00000368535.2_3'UTR|PAOX_ENST00000480071.2_Silent_p.I284I	NM_152911.2	NP_690875.1	Q6QHF9	PAOX_HUMAN	polyamine oxidase (exo-N4-amino)	422					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|urinary_tract(2)	23		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		ACCATGTCATCGTCACCGTGC	0.617000													31	15					0	0	0.804634	0	0
SCN3A	6328	broad.mit.edu	37	2	165984456	165984456	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:165984456G>A	ENST00000360093.3	-	18	3569	c.3078C>T	c.(3076-3078)ttC>ttT	p.F1026F	SCN3A_ENST00000409101.3_Silent_p.F977F|SCN3A_ENST00000283254.7_Silent_p.F1026F	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1026						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	AGGCTTTTTGGAAACACTCCC	0.348000													24	25					0	0	0.693898	0	0
RRAD	6236	broad.mit.edu	37	16	66956131	66956131	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:66956131C>T	ENST00000299759.6	-	5	1025	c.775G>A	c.(775-777)Gaa>Aaa	p.E259K	RRAD_ENST00000420652.1_Missense_Mutation_p.E259K			P55042	RAD_HUMAN	Ras-related associated with diabetes	259					small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|urinary_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		GCGTTGGCTTCTTTGCTGTCC	0.587000													31	8					0	0	0.796494	0	0
GLG1	2734	broad.mit.edu	37	16	74530429	74530429	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:74530429G>A	ENST00000422840.2	-	5	887	c.888C>T	c.(886-888)ctC>ctT	p.L296L	GLG1_ENST00000205061.5_Silent_p.L296L|GLG1_ENST00000447066.2_Silent_p.L285L	NM_001145667.1	NP_001139139.1	Q92896	GSLG1_HUMAN	golgi glycoprotein 1	296						Golgi membrane|integral to membrane	receptor binding			breast(2)|cervix(2)|endometrium(6)|kidney(8)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(1)	57						CAGCCACCCGGAGAATGGCTT	0.463000													36	27					0	0	0.788014	0	0
SCAND3	114821	broad.mit.edu	37	6	28540518	28540518	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:28540518G>A	ENST00000452236.2	-	4	3765	c.3148C>T	c.(3148-3150)Cat>Tat	p.H1050Y		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1050					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						agttgcttatgatcagcttcc	0.303000													37	61					0	0	0.870114	0	0
NES	10763	broad.mit.edu	37	1	156639851	156639851	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:156639851G>A	ENST00000368223.3	-	4	4261	c.4129C>T	c.(4129-4131)Cct>Tct	p.P1377S		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1377	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGAAGAAAAGGTGCCTCAGTC	0.622000													22	6					0	0	0.667858	0	0
RYR2	6262	broad.mit.edu	37	1	237875104	237875104	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:237875104C>T	ENST00000366574.2	+	71	10607	c.10290C>T	c.(10288-10290)ttC>ttT	p.F3430F	RYR2_ENST00000360064.6_Silent_p.F3428F|RYR2_ENST00000542537.1_Silent_p.F3414F	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3430					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATATGTCTTTCCTTATTACTG	0.308000													10	3					0	0	0.435327	0	0
DSG4	147409	broad.mit.edu	37	18	28968463	28968463	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:28968463G>A	ENST00000359747.4	+	4	379	c.350G>A	c.(349-351)aGa>aAa	p.R117K	RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.R117K	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	117	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GTGGTAGACAGAGAAATAACT	0.358000													11	27					0	0	0.479597	0	0
ASPHD2	57168	broad.mit.edu	37	22	26829832	26829832	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr22:26829832G>A	ENST00000215906.5	+	2	689	c.251G>A	c.(250-252)cGg>cAg	p.R84Q		NM_020437.4	NP_065170.2	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	84					peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(4)|urinary_tract(1)	16						GAGCAGCCCCGGCCCTACGTC	0.642000													36	61					0	0	0.870114	0	0
CLCN4	1183	broad.mit.edu	37	X	10181783	10181783	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:10181783G>A	ENST00000380833.4	+	11	2030	c.1639G>A	c.(1639-1641)Gag>Aag	p.E547K	CLCN4_ENST00000380829.1_Missense_Mutation_p.E516K|CLCN4_ENST00000421085.2_Missense_Mutation_p.E453K	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	547						early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CGGGGGTCTGGAGTACATCGT	0.527000													4	64					0	0	0.184627	0	0
ITGB8	3696	broad.mit.edu	37	7	20406796	20406796	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:20406796C>T	ENST00000222573.3	+	3	1059	c.375C>T	c.(373-375)atC>atT	p.I125I	ITGB8_ENST00000537992.1_5'UTR	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8	125					cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						AAGTGTCTATCCAGCTGCGTC	0.343000													46	24					0	0	0.870114	0	0
SPACA3	124912	broad.mit.edu	37	17	31324751	31324751	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:31324751C>T	ENST00000580599.1	+	6	805	c.396C>T	c.(394-396)tgC>tgT	p.C132C	SPACA3_ENST00000394637.2_3'UTR|SPACA3_ENST00000269053.3_Silent_p.C201C|SPACA3_ENST00000394638.1_Silent_p.C98C			Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	201					cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			breast(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(9;0.193)			GGCATCACTGCCAGGGAAAAG	0.537000													15	70					0	0	0.575678	0	0
PCDH10	57575	broad.mit.edu	37	4	134072069	134072069	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:134072069C>T	ENST00000264360.4	+	1	1600	c.774C>T	c.(772-774)tcC>tcT	p.S258S		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	258	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ACACTGTGTCCCTACCAGAGA	0.632000													42	25					0	0	0.870114	0	0
GGA1	26088	broad.mit.edu	37	22	38021006	38021006	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr22:38021006C>T	ENST00000406772.1	+	11	1296	c.644C>T	c.(643-645)aCc>aTc	p.T215I	GGA1_ENST00000337437.4_Missense_Mutation_p.T255I|GGA1_ENST00000343632.4_Missense_Mutation_p.T288I|GGA1_ENST00000325180.8_Intron|GGA1_ENST00000381756.5_Missense_Mutation_p.T305I	NM_001172688.1	NP_001166159.1	Q9UJY5	GGA1_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	288	GAT.|Interaction with ARF3.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	10	Melanoma(58;0.0574)					GACAACCTCACCCAGGTGATC	0.642000													3	8					0	0	0.184627	0	0
OR6C3	254786	broad.mit.edu	37	12	55725861	55725861	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:55725861C>T	ENST00000379667.1	+	1	377	c.377C>T	c.(376-378)cCc>cTc	p.P126L		NM_054104.1	NP_473445.1	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C, member 3	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	11						ATCTGCAAGCCCCTTCATTAC	0.453000													24	73					0	0	0.717897	0	0
FMNL2	114793	broad.mit.edu	37	2	153435417	153435417	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:153435417G>A	ENST00000288670.9	+	8	1088	c.721G>A	c.(721-723)Gtc>Atc	p.V241I		NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	241	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						TTTCAACATGGTCATGTCTCA	0.368000													11	13					0	0	0.435327	0	0
FUNDC2P2	388965	broad.mit.edu	37	2	84517908	84517908	+	RNA	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:84517908C>T	ENST00000331369.5	+	0	102																											CTCGCAGATCCCCTGCGTGTG	0.602000													3	8					0	0	0.150653	0	0
ACACA	31	broad.mit.edu	37	17	35536293	35536293	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:35536293G>A	ENST00000353139.5	-	41	5468	c.4987C>T	c.(4987-4989)Cct>Tct	p.P1663S	ACACA_ENST00000360679.3_Missense_Mutation_p.P1568S|ACACA_ENST00000335166.5_Missense_Mutation_p.P1548S|ACACA_ENST00000394406.2_Missense_Mutation_p.P1626S	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	1626					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GAAGGCAGAGGGGGAGATGGA	0.453000													29	33					0	0	0.779181	0	0
DRD1	1812	broad.mit.edu	37	5	174869909	174869909	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:174869909G>A	ENST00000393752.2	-	2	1186	c.194C>T	c.(193-195)tCc>tTc	p.S65F		NM_000794.3	NP_000785.1	P21728	DRD1_HUMAN	dopamine receptor D1	65					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	CACAGCCAAGGAGATGACAAA	0.572000													24	6					0	0	0.693898	0	0
RGAG1	57529	broad.mit.edu	37	X	109696473	109696473	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:109696473G>A	ENST00000465301.2	+	3	2874	c.2628G>A	c.(2626-2628)atG>atA	p.M876I	RGAG1_ENST00000540313.1_Missense_Mutation_p.M876I	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	876										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						CATCACAAATGATGCCCACAG	0.547000													11	89					0	0	0.411799	0	0
AGK	55750	broad.mit.edu	37	7	141349069	141349069	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:141349069G>A	ENST00000355413.4	+	14	1242	c.982G>A	c.(982-984)Gaa>Aaa	p.E328K	AGK_ENST00000473247.1_Missense_Mutation_p.E300K|AGK_ENST00000535825.1_3'UTR	NM_018238.3	NP_060708.1	Q53H12	AGK_HUMAN	acylglycerol kinase	328					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(3)	17	Melanoma(164;0.0171)					TTAGAGCAAAGAAGATTTTCT	0.393000													14	31					0	0	0.539581	0	0
TMEM225	338661	broad.mit.edu	37	11	123753896	123753896	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:123753896C>T	ENST00000375026.2	-	4	843	c.627G>A	c.(625-627)gtG>gtA	p.V209V		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	209						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						TTAGGGAATTCACAGTGTGTG	0.398000													30	22					0	0	0.769981	0	0
ANKS1B	56899	broad.mit.edu	37	12	99793546	99793546	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:99793546C>T	ENST00000547776.2	-	12	1618	c.1619G>A	c.(1618-1620)cGa>cAa	p.R540Q	ANKS1B_ENST00000547010.1_Missense_Mutation_p.R120Q|ANKS1B_ENST00000329257.7_Missense_Mutation_p.R540Q	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	540						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GTGATTCATTCGGTGAAAATC	0.418000													12	43					0	0	0.539581	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94898759	94898759	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:94898759G>A	ENST00000289495.5	+	12	3160	c.2944G>A	c.(2944-2946)Gat>Aat	p.D982N	PPP1R9A_ENST00000433360.1_Missense_Mutation_p.D1022N|PPP1R9A_ENST00000340694.4_Intron|PPP1R9A_ENST00000424654.1_Missense_Mutation_p.D1000N|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.D1000N|PPP1R9A_ENST00000433881.1_Intron	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	970	Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GTCTGATCATGATGTGGAAGA	0.408000										HNSCC(28;0.073)			43	85					0	0	0.870114	0	0
BAGE2	85319	broad.mit.edu	37	21	11039340	11039340	+	RNA	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr21:11039340C>T	ENST00000470054.1	-	0	863									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCAATTTGATCTTCGCCACAA	0.378000													21	164					0	0	0.639603	0	0
MPHOSPH9	10198	broad.mit.edu	37	12	123646767	123646767	+	Splice_Site	SNP	T	T	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:123646767T>A	ENST00000606320.1	-	21	3236		c.e21-2		MPHOSPH9_ENST00000302349.5_Splice_Site|MPHOSPH9_ENST00000541076.2_Splice_Site|MPHOSPH9_ENST00000392425.3_Splice_Site			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9						M phase of mitotic cell cycle	centriole|Golgi membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		ATATCAAATCTATTGAATGAA	0.353000													16	33					0	0	0.557998	0	0
SLC10A2	6555	broad.mit.edu	37	13	103710711	103710711	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr13:103710711G>A	ENST00000245312.3	-	2	995	c.399C>T	c.(397-399)tcC>tcT	p.S133S		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	133					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CAAGCAGTGTGGAGCATGTGG	0.443000													19	9					0	0	0.624587	0	0
PTPRT	11122	broad.mit.edu	37	20	41385114	41385114	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:41385114G>A	ENST00000373198.3	-	6	1082	c.847C>T	c.(847-849)Ctg>Ttg	p.L283L	PTPRT_ENST00000373193.3_Silent_p.L283L|PTPRT_ENST00000356100.2_Silent_p.L283L|PTPRT_ENST00000373201.1_Silent_p.L283L|PTPRT_ENST00000373187.1_Silent_p.L283L|PTPRT_ENST00000373184.1_Silent_p.L283L|PTPRT_ENST00000373190.1_Silent_p.L283L	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	283	Ig-like C2-type.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TTCACGATCAGCTCCGCGTAG	0.577000													24	24					0	0	0.788014	0	0
CAP2	10486	broad.mit.edu	37	6	17463250	17463250	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:17463250C>T	ENST00000229922.2	+	4	778	c.246C>T	c.(244-246)ttC>ttT	p.F82F	CAP2_ENST00000489374.1_Silent_p.F82F|CAP2_ENST00000465994.1_Silent_p.F82F|CAP2_ENST00000378990.2_Intron|CAP2_ENST00000493172.1_Intron	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	82					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			ACAGTGCTTTCCAGGCCCAGC	0.502000													10	67					0	0	0.457914	0	0
MYH8	4626	broad.mit.edu	37	17	10317277	10317277	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:10317277C>T	ENST00000403437.2	-	12	1183	c.1089G>A	c.(1087-1089)ggG>ggA	p.G363G	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	363	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						ATTTCATGTTCCCATAATGCA	0.448000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				56	49					0	0	0.870114	0	0
SEMA4B	10509	broad.mit.edu	37	15	90768390	90768390	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:90768390A>T	ENST00000411539.2	+	10	1645	c.1385A>T	c.(1384-1386)gAt>gTt	p.D462V	SEMA4B_ENST00000332496.6_Missense_Mutation_p.D462V|SEMA4B_ENST00000379122.3_Missense_Mutation_p.D457V	NM_198925.2	NP_945119.1			sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B											NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)	12	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			CACACCTACGATGTCCTCTTC	0.672000													7	2					0	0	0.278610	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47533331	47533331	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:47533331C>T	ENST00000334194.3	+	1	172	c.169C>T	c.(169-171)Cac>Tac	p.H57Y		NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	57						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						GTTCTATGGCCACAAGGAGGT	0.473000													46	17					0	0	0.870114	0	0
DLC1	10395	broad.mit.edu	37	8	12957987	12957987	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:12957987G>A	ENST00000276297.4	-	9	2268	c.1859C>T	c.(1858-1860)tCc>tTc	p.S620F	DLC1_ENST00000358919.2_Missense_Mutation_p.S183F|DLC1_ENST00000520226.1_Missense_Mutation_p.S109F|DLC1_ENST00000512044.2_Missense_Mutation_p.S217F	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	620					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GCTGATGACGGAGTTAGTCCG	0.642000													60	43					0	0	0.870114	0	0
ANK3	288	broad.mit.edu	37	10	61830238	61830238	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr10:61830238G>A	ENST00000280772.1	-	37	10592	c.10401C>T	c.(10399-10401)atC>atT	p.I3467I	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3467					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CCTCCTCCTCGATAACTTCAA	0.458000													31	17					0	0	0.827153	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18435524	18435524	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:18435524G>A	ENST00000433979.1	+	2	625	c.509G>A	c.(508-510)gGa>gAa	p.G170E	PIK3C2G_ENST00000538779.1_Missense_Mutation_p.G170E|PIK3C2G_ENST00000535651.1_Missense_Mutation_p.G170E|RERGL_ENST00000541632.1_Intron|PIK3C2G_ENST00000266497.5_Missense_Mutation_p.G170E	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	170					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				TACCATATAGGATTTGAAAGT	0.338000													15	43					0	0	0.520397	0	0
OR7G1	125962	broad.mit.edu	37	19	9225778	9225778	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:9225778A>G	ENST00000293614.1	-	1	661	c.662T>C	c.(661-663)aTa>aCa	p.I221T	OR7G1_ENST00000541538.1_Missense_Mutation_p.I221T			Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G, member 1	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	20						AGAGGTGACTATTTGAGAATA	0.408000													29	22					0	0	0.788014	0	0
CNTN6	27255	broad.mit.edu	37	3	1443200	1443200	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:1443200G>A	ENST00000446702.2	+	21	3415	c.2788G>A	c.(2788-2790)Gaa>Aaa	p.E930K	CNTN6_ENST00000350110.2_Missense_Mutation_p.E930K|CNTN6_ENST00000539053.1_Missense_Mutation_p.E858K			Q9UQ52	CNTN6_HUMAN	contactin 6	930	Fibronectin type-III 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AAAAACCATGGAAAATGAGTC	0.368000													12	15					0	0	0.435327	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059343	152059343	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:152059343G>A	ENST00000368806.1	-	3	879	c.815C>T	c.(814-816)cCa>cTa	p.P272L		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	272							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			ATCTTCACATGGTCTTTGTGT	0.433000													77	21					0	0	0.870114	0	0
FBXL13	222235	broad.mit.edu	37	7	102524023	102524023	+	Missense_Mutation	SNP	C	C	T	rs137980271		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:102524023C>T	ENST00000393772.2	-	13	1643	c.1217G>A	c.(1216-1218)cGa>cAa	p.R406Q	FBXL13_ENST00000379306.3_Intron|FBXL13_ENST00000313221.4_Missense_Mutation_p.R406Q|FBXL13_ENST00000379305.3_Missense_Mutation_p.R406Q|FBXL13_ENST00000456695.1_Intron|FBXL13_ENST00000379308.3_Missense_Mutation_p.R406Q|FBXL13_ENST00000436908.1_Missense_Mutation_p.R406Q|FBXL13_ENST00000455112.2_Missense_Mutation_p.R406Q			Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13	406										NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|skin(3)|stomach(1)	27						ACCTTCAAATCGGATCTTTCT	0.353000													24	25					0	0	0.717897	0	0
BRS3	680	broad.mit.edu	37	X	135570657	135570657	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:135570657C>T	ENST00000370648.3	+	1	612	c.384C>T	c.(382-384)ctC>ctT	p.L128L		NM_001727.1	NP_001718.1	P32247	BRS3_HUMAN	bombesin-like receptor 3	128					adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|pancreas(1)|prostate(1)	23	Acute lymphoblastic leukemia(192;0.000127)					TCATCCGGCTCACTTCTGTTG	0.443000													5	73					0	0	0.184627	0	0
YEATS2	55689	broad.mit.edu	37	3	183495355	183495355	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:183495355C>T	ENST00000305135.5	+	19	2798	c.2603C>T	c.(2602-2604)tCa>tTa	p.S868L		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	868					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GGCCAGCCATCACCCCAGACT	0.423000													29	31					0	0	0.819951	0	0
ANAPC10	10393	broad.mit.edu	37	4	145985797	145985797	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:145985797G>A	ENST00000507656.1	-	4	347	c.254C>T	c.(253-255)tCt>tTt	p.S85F	ANAPC10_ENST00000512680.1_Missense_Mutation_p.S85F|ANAPC10_ENST00000510270.1_5'UTR|ANAPC10_ENST00000309439.5_Missense_Mutation_p.S85F|ANAPC10_ENST00000451299.2_Missense_Mutation_p.S85F	NM_001256706.1	NP_001243635.1	Q9UM13	APC10_HUMAN	anaphase promoting complex subunit 10	85	DOC.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin-protein ligase activity			endometrium(1)|large_intestine(3)|lung(1)|skin(1)	6	all_hematologic(180;0.151)					GCTTTCATCAGATTTGTAGTC	0.294000													23	4					0	0	0.624587	0	0
BRINP2	57795	broad.mit.edu	37	1	177247853	177247853	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:177247853C>T	ENST00000361539.4	+	7	1479	c.1167C>T	c.(1165-1167)atC>atT	p.I389I	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		389						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						CCCATCGGATCCTACGCCGGC	0.612000													75	14					0	0	0.870114	0	0
C8A	731	broad.mit.edu	37	1	57378172	57378172	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:57378172G>A	ENST00000361249.3	+	10	1573	c.1477G>A	c.(1477-1479)Gaa>Aaa	p.E493K		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	493	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GTATCTGATGGAATTCAATGC	0.632000													37	18					0	0	0.847076	0	0
RNF165	494470	broad.mit.edu	37	18	44030274	44030274	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:44030274C>T	ENST00000269439.7	+	5	682	c.631C>T	c.(631-633)Cga>Tga	p.R211*	RNF165_ENST00000543885.1_Nonsense_Mutation_p.R19*	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	211							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		CCATGAAATCCGAAACTACCC	0.517000													16	30					0	0	0.592651	0	0
MLIP	90523	broad.mit.edu	37	6	53989510	53989510	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:53989510G>A	ENST00000514921.1	+	3	572	c.459G>A	c.(457-459)ggG>ggA	p.G153G	MLIP_ENST00000370877.2_Silent_p.G101G|MLIP_ENST00000511744.1_3'UTR|MLIP_ENST00000274897.5_Silent_p.G153G|MLIP_ENST00000370876.2_Silent_p.G91G|MLIP_ENST00000502396.1_Silent_p.G164G|MLIP_ENST00000358276.5_Silent_p.G147G|MLIP_ENST00000509997.1_Silent_p.G101G			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	153						nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						CCCCAGGGGGGATTGGCACCG	0.532000													14	40					0	0	0.575678	0	0
HMGXB4	10042	broad.mit.edu	37	22	35660861	35660861	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr22:35660861C>T	ENST00000216106.5	+	5	608	c.480C>T	c.(478-480)ccC>ccT	p.P160P	HMGXB4_ENST00000444518.2_Silent_p.P51P	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	160					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGGAACTACCCCTAGAGGATG	0.473000													20	26					0	0	0.592651	0	0
ENTPD8	377841	broad.mit.edu	37	9	140332468	140332468	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:140332468C>T	ENST00000371506.2	-	3	378	c.195G>A	c.(193-195)aaG>aaA	p.K65K	ENTPD8_ENST00000472938.1_Silent_p.K65K|ENTPD8_ENST00000344119.2_Silent_p.K65K	NM_001033113.1	NP_001028285.1	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	65						integral to membrane|plasma membrane	ATP binding			biliary_tract(1)|lung(4)|prostate(1)|skin(1)	7	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		TGCCATTCTCCTTGTTCGCCA	0.622000													11	28					0	0	0.435327	0	0
RBM12B	389677	broad.mit.edu	37	8	94747873	94747873	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:94747873G>A	ENST00000399300.2	-	3	979	c.766C>T	c.(766-768)Cca>Tca	p.P256S	RBM12B_ENST00000517700.1_Missense_Mutation_p.P256S|RBM12B_ENST00000520961.1_Intron	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	256							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			ATTCCTCTTGGTGGAGAATGT	0.393000													30	68					0	0	0.740014	0	0
SRCAP	10847	broad.mit.edu	37	16	30748990	30748990	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:30748990C>T	ENST00000262518.4	+	34	8014	c.7629C>T	c.(7627-7629)ctC>ctT	p.L2543L	SRCAP_ENST00000344771.4_Silent_p.L2385L|SRCAP_ENST00000395059.2_Silent_p.L2481L	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2543	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TCACTAATCTCCCCTTGGGCT	0.572000													8	81					0	0	0.335167	0	0
OR3A1	4994	broad.mit.edu	37	17	3195151	3195151	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:3195151G>A	ENST00000323404.1	-	1	725	c.726C>T	c.(724-726)tcC>tcT	p.S242S	RP11-64J4.2_ENST00000573491.1_RNA	NM_002550.2	NP_002541.2	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A, member 1	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	20						AGCCACATGTGGAGAAGGCTT	0.498000													19	29					0	0	0.592651	0	0
HIST1H1B	3009	broad.mit.edu	37	6	27835291	27835291	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:27835291G>A	ENST00000331442.3	-	1	68	c.17C>T	c.(16-18)cCt>cTt	p.P6L		NM_005322.2	NP_005313.1	P16401	H15_HUMAN	histone cluster 1, H1b	6					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(12)|prostate(2)|upper_aerodigestive_tract(2)	24						TGTCTCGGCAGGAGCGGTTTC	0.587000													15	12					0	0	0.624587	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573554	140573554	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:140573554G>A	ENST00000239446.4	+	1	1613	c.1429G>A	c.(1429-1431)Gac>Aac	p.D477N		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		477	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGCGCCACAGACAGAGACTC	0.657000													28	84					0	0	0.779181	0	0
INO80D	54891	broad.mit.edu	37	2	206911278	206911278	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:206911278G>A	ENST00000403263.1	-	5	1427	c.1023C>T	c.(1021-1023)ccC>ccT	p.P341P		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	341					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						CAACCTGGTAGGGCGAGGCCT	0.458000													36	35					0	0	0.870114	0	0
GPR139	124274	broad.mit.edu	37	16	20043681	20043681	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:20043681C>T	ENST00000570682.1	-	2	738	c.438G>A	c.(436-438)cgG>cgA	p.R146R		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	146						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						CAATGACTTTCCGGGTGCGGG	0.512000													94	43					0	0	0.870114	0	0
OR51D1	390038	broad.mit.edu	37	11	4661869	4661869	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:4661869C>T	ENST00000357605.2	+	1	925	c.849C>T	c.(847-849)ctC>ctT	p.L283L		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCACCTCCCTCCTCCATGTGG	0.532000													54	35					0	0	0.870114	0	0
PLCB2	5330	broad.mit.edu	37	15	40580978	40580978	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:40580978G>A	ENST00000260402.3	-	32	3745	c.3496C>T	c.(3496-3498)Cca>Tca	p.P1166S	PLCB2_ENST00000456256.2_Missense_Mutation_p.P1151S|PLCB2_ENST00000557821.1_Missense_Mutation_p.P1162S	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	1166					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		CACAGCTCTGGGGGGCACTCG	0.627000													15	35					0	0	0.520397	0	0
TOX2	84969	broad.mit.edu	37	20	42682992	42682992	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:42682992G>A	ENST00000358131.5	+	5	940	c.732G>A	c.(730-732)ccG>ccA	p.P244P	TOX2_ENST00000372999.1_Silent_p.P193P|TOX2_ENST00000341197.3_Silent_p.P235P|TOX2_ENST00000423191.1_Silent_p.P193P|TOX2_ENST00000435864.2_Silent_p.P113P	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	244					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CCAAGAACCCGAAGAAGAAGA	0.542000													7	11					0	0	0.335167	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174830	150174830	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:150174830G>A	ENST00000307271.3	+	5	2534	c.1960G>A	c.(1960-1962)Gaa>Aaa	p.E654K		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	654						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GTCCCAAGCCGAAAAACTCCT	0.463000													29	33					0	0	0.769981	0	0
COPZ1	22818	broad.mit.edu	37	12	54734318	54734318	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:54734318C>T	ENST00000549043.1	+	2	125	c.30C>T	c.(28-30)ttC>ttT	p.F10F	COPZ1_ENST00000455864.2_Intron|COPZ1_ENST00000262061.2_Intron|COPZ1_ENST00000551779.1_Intron|COPZ1_ENST00000553231.1_Intron|RP11-968A15.8_ENST00000553061.1_RNA|COPZ1_ENST00000552362.1_Intron|COPZ1_ENST00000552218.1_Intron|COPZ1_ENST00000549116.1_Intron|COPZ1_ENST00000548753.1_Intron|COPZ1_ENST00000548281.1_Intron|COPZ1_ENST00000416254.2_Intron			P61923	COPZ1_HUMAN	coatomer protein complex, subunit zeta 1	0					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol				kidney(1)|lung(4)	5						AAGGTATGTTCGTATCTCTTC	0.488000													28	41					0	0	0.750413	0	0
SUGP1	57794	broad.mit.edu	37	19	19414741	19414741	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:19414741A>T	ENST00000334782.5	-	5	662	c.650T>A	c.(649-651)cTc>cAc	p.L217H	SUGP1_ENST00000585763.1_Intron|SUGP1_ENST00000247001.5_Intron			Q8IWZ8	SUGP1_HUMAN	SURP and G patch domain containing 1	637					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	22						ACAACGACAGAGGGGGTGGGG	0.577000													15	91					0	0	0.479597	0	0
SLC9A6	10479	broad.mit.edu	37	X	135092658	135092658	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:135092658G>A	ENST00000370695.4	+	7	992	c.957G>A	c.(955-957)gcG>gcA	p.A319A	SLC9A6_ENST00000370698.3_Silent_p.A287A|SLC9A6_ENST00000370701.1_Silent_p.A267A	NM_001042537.1	NP_001036002.1	Q92581	SL9A6_HUMAN	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	287					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					ATGTCACAGCGATGTTCAAGT	0.428000													8	69					0	0	0.307466	0	0
MICAL3	57553	broad.mit.edu	37	22	18300933	18300933	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr22:18300933G>A	ENST00000441493.2	-	26	4846	c.4494C>T	c.(4492-4494)ccC>ccT	p.P1498P		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1498	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		CAGGCTCCCGGGGGGGCCGCA	0.682000													7	13					0	0	0.335167	0	0
ACACA	31	broad.mit.edu	37	17	35562785	35562785	+	Splice_Site	SNP	A	A	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:35562785A>G	ENST00000353139.5	-	33	4431	c.3948_splice	c.e33-1	p.V1317_splice	ACACA_ENST00000360679.3_Splice_Site_p.V1222_splice|ACACA_ENST00000335166.5_Splice_Site_p.V1202_splice|ACACA_ENST00000394406.2_Splice_Site_p.V1280_splice	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	1280					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ATCCCTGGGAACCTGTAACTC	0.398000													26	93					0	0	0.706142	0	0
KCNH4	23415	broad.mit.edu	37	17	40315707	40315707	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:40315707G>A	ENST00000264661.3	-	13	2726	c.2394C>T	c.(2392-2394)ccC>ccT	p.P798P	KCNH4_ENST00000607371.1_Silent_p.P798P	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	798					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGCACCTGGGGGGGCCGTGAG	0.667000													12	7					0	0	0.520397	0	0
POU2F2	5452	broad.mit.edu	37	19	42626663	42626663	+	Splice_Site	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:42626663C>T	ENST00000389341.5	-	2	160	c.94_splice	c.e2+1	p.D32_splice	POU2F2_ENST00000526816.2_Splice_Site_p.D32_splice|POU2F2_ENST00000524801.2_5'UTR|POU2F2_ENST00000342301.4_Splice_Site_p.D32_splice|POU2F2_ENST00000560558.1_Splice_Site_p.D32_splice|POU2F2_ENST00000560398.1_Splice_Site_p.D32_splice|POU2F2_ENST00000533720.1_Splice_Site_p.D32_splice|POU2F2_ENST00000529952.1_Splice_Site_p.D32_splice|POU2F2_ENST00000529067.1_Splice_Site_p.D32_splice	NM_001207025.2|NM_001247994.1|NM_002698.4	NP_001193954.1|NP_001234923.1|NP_002689.1	P09086	PO2F2_HUMAN	POU class 2 homeobox 2	32					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(69;0.059)				GCCCACCCACCTGTGTGCTCT	0.627000													19	16					0	0	0.592651	0	0
CANT1	124583	broad.mit.edu	37	17	76993389	76993389	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:76993389G>A	ENST00000302345.2	-	2	810	c.316C>T	c.(316-318)Cga>Tga	p.R106*	CANT1_ENST00000591773.1_Nonsense_Mutation_p.R106*|CANT1_ENST00000392446.5_Nonsense_Mutation_p.R106*	NM_001159773.1|NM_138793.3	NP_001153245.1|NP_620148.1	Q8WVQ1	CANT1_HUMAN	calcium activated nucleotidase 1	106					positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to membrane	calcium ion binding|nucleoside-diphosphatase activity|signal transducer activity		CANT1/ETV4(3)	cervix(1)|endometrium(1)|large_intestine(2)|lung(10)|prostate(1)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(99;0.0362)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			ACTGCGATTCGATACCGAATC	0.567000			T	ETV4	prostate								55	127					0	0	0.870114	0	0
MPP1	4354	broad.mit.edu	37	X	154020553	154020553	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:154020553G>A	ENST00000413259.3	-	3	412	c.20C>T	c.(19-21)tCg>tTg	p.S7L	MPP1_ENST00000393531.1_Missense_Mutation_p.S37L|MPP1_ENST00000462825.1_Intron|MPP1_ENST00000369534.3_Missense_Mutation_p.S37L	NM_001166462.1	NP_001159934.1	Q00013	EM55_HUMAN	membrane protein, palmitoylated 1, 55kDa	37					regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(9)|ovary(2)|prostate(1)	21	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CAATGGATGCGATACAGCCTG	0.532000													4	40					0	0	0.248553	0	0
HELZ2	85441	broad.mit.edu	37	20	62192810	62192810	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:62192810G>A	ENST00000467148.1	-	13	6915	c.6846C>T	c.(6844-6846)acC>acT	p.T2282T	HELZ2_ENST00000427522.2_Silent_p.T1713T	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		GGTGGTGCAGGGTGATGCTCC	0.637000													38	107					0	0	0.870114	0	0
UPF3B	65109	broad.mit.edu	37	X	118971941	118971941	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:118971941G>A	ENST00000276201.2	-	10	1150	c.1081C>T	c.(1081-1083)Cga>Tga	p.R361*	UPF3B_ENST00000345865.2_Nonsense_Mutation_p.R348*	NM_080632.2	NP_542199.1	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B (yeast)	361	Sufficient for association with EJC core.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding	p.R361*(1)		breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|prostate(1)	30						TCTCTTTCTCGAAGTATGCGC	0.463000													4	53					0	0	0.184627	0	0
CYB5R1	51706	broad.mit.edu	37	1	202932811	202932811	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:202932811G>A	ENST00000367249.4	-	7	678	c.604C>T	c.(604-606)Cct>Tct	p.P202S	CYB5R1_ENST00000497655.1_5'UTR	NM_016243.2	NP_057327.2	Q9UHQ9	NB5R1_HUMAN	cytochrome b5 reductase 1	202					sterol biosynthetic process	integral to membrane	cytochrome-b5 reductase activity			breast(1)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(75;0.141)			GGATCTTCAGGGACTTTCAGG	0.517000													16	11					0	0	0.592651	0	0
PPFIA4	8497	broad.mit.edu	37	1	203040888	203040888	+	Splice_Site	SNP	C	C	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:203040888C>G	ENST00000367240.2	+	27	3857	c.3330_splice	c.e27+1	p.D1110_splice	PPFIA4_ENST00000599966.1_Splice_Site_p.D616_splice|PPFIA4_ENST00000272198.6_Splice_Site_p.D625_splice|PPFIA4_ENST00000414050.2_Splice_Site_p.D838_splice|PPFIA4_ENST00000295706.4_Splice_Site_p.D616_splice|PPFIA4_ENST00000447715.2_Splice_Site_p.D1109_splice			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	625					cell communication	cell surface|cytoplasm	protein binding	p.D625D(1)|p.D1255D(1)		NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						AGCTGGATGACGTGAGTACCT	0.522000													8	5					0	0	0.387290	0	0
PELI2	57161	broad.mit.edu	37	14	56755318	56755318	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:56755318C>T	ENST00000267460.4	+	4	759	c.473C>T	c.(472-474)gCc>gTc	p.A158V		NM_021255.2	NP_067078.1	Q9HAT8	PELI2_HUMAN	pellino E3 ubiquitin protein ligase family member 2	158					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			kidney(6)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	22						ATATTCGCCGCCGGATTTGAC	0.438000													16	7					0	0	0.608945	0	0
ADAM29	11086	broad.mit.edu	37	4	175898946	175898946	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:175898946C>T	ENST00000359240.3	+	5	2940	c.2270C>T	c.(2269-2271)tCc>tTc	p.S757F	ADAM29_ENST00000514159.1_Missense_Mutation_p.S757F|ADAM29_ENST00000445694.1_Missense_Mutation_p.S757F|ADAM29_ENST00000404450.4_Missense_Mutation_p.S757F|RP13-577H12.2_ENST00000507525.1_RNA	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	757	9 X 9 AA approximate repeats.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GTGATGCCTTCCCAGAGTCAA	0.562000													84	32					0	0	0.870114	0	0
POLR2A	5430	broad.mit.edu	37	17	7417412	7417412	+	Silent	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:7417412T>C	ENST00000322644.6	+	29	6228	c.5829T>C	c.(5827-5829)acT>acC	p.T1943T		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	1943	52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				ACTCTCCCACTTCCCCTGGTT	0.632000													31	33					0	0	0.834066	0	0
CCDC60	160777	broad.mit.edu	37	12	119957972	119957972	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:119957972G>A	ENST00000327554.2	+	9	1480	c.1015G>A	c.(1015-1017)Gaa>Aaa	p.E339K	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	339										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		TGCTTATAAGGAAATGCAGAC	0.483000													29	82					0	0	0.760397	0	0
BMP6	654	broad.mit.edu	37	6	7880313	7880313	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:7880313C>A	ENST00000283147.6	+	6	1530	c.1371C>A	c.(1369-1371)aaC>aaA	p.N457K		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	457					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					ATGCAACCAACCACGCGATTG	0.483000													48	103					2.2129e-31	2.24793e-31	0.870114	1	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:207025366G>A	ENST00000392222.2	+	2	510	c.135G>A	c.(133-135)ccG>ccA	p.P45P	EEF1B2_ENST00000236957.5_Silent_p.P45P|EEF1B2_ENST00000392221.1_Silent_p.P45P	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(5)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													4	109					0	0	0.184627	0	0
PLCD3	113026	broad.mit.edu	37	17	43196224	43196224	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:43196224G>A	ENST00000322765.5	-	5	984	c.871C>T	c.(871-873)Cgc>Tgc	p.R291C	PLCD3_ENST00000540511.1_5'UTR	NM_133373.3	NP_588614.1	Q8N3E9	PLCD3_HUMAN	phospholipase C, delta 3	291					intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity	p.R291S(2)		breast(2)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	17					Phosphatidylserine(DB00144)	TGCTGGGCGCGGGCCAGTGTG	0.652000													7	10					0	0	0.335167	0	0
FAM183B	340286	broad.mit.edu	37	7	38725602	38725602	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:38725602C>T	ENST00000409072.3	-	2	938	c.4G>A	c.(4-6)Gcg>Acg	p.A2T						family with sequence similarity 183, member B											endometrium(1)|lung(7)	8						GGGTGTCCCGCCATAGCCTTG	0.602000													19	10					0	0	0.639603	0	0
DAZAP2	9802	broad.mit.edu	37	12	51634702	51634702	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:51634702C>T	ENST00000412716.3	+	3	796	c.180C>T	c.(178-180)acC>acT	p.T60T	DAZAP2_ENST00000549732.2_Intron|DAZAP2_ENST00000549555.1_Silent_p.T60T|DAZAP2_ENST00000604900.1_Silent_p.T60T|DAZAP2_ENST00000551534.1_3'UTR|DAZAP2_ENST00000551313.1_5'UTR|DAZAP2_ENST00000439799.2_Intron|DAZAP2_ENST00000449723.3_Silent_p.T60T|DAZAP2_ENST00000425012.2_Silent_p.T60T			Q15038	DAZP2_HUMAN	DAZ associated protein 2	60	Pro-rich.						WW domain binding			haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)	6						CAGTCCCCACCATGTCAGCCG	0.512000													25	67					0	0	0.729181	0	0
STXBP4	252983	broad.mit.edu	37	17	53237185	53237185	+	Silent	SNP	C	C	T	rs115962086	byFrequency	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:53237185C>T	ENST00000376352.2	+	18	1782	c.1575C>T	c.(1573-1575)atC>atT	p.I525I	STXBP4_ENST00000434978.2_Silent_p.I503I	NM_178509.5	NP_848604.3	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	525	WW.					cytoplasm	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19						CATCCTGGATCCATCCCGTGA	0.433000													16	49					0	0	0.608945	0	0
ACAN	176	broad.mit.edu	37	15	89392754	89392754	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:89392754C>T	ENST00000439576.2	+	10	2192	c.1818C>T	c.(1816-1818)gcC>gcT	p.A606A	ACAN_ENST00000561243.1_Silent_p.A606A|ACAN_ENST00000559004.1_Silent_p.A606A|ACAN_ENST00000558207.1_Silent_p.A606A|ACAN_ENST00000352105.7_Silent_p.A606A	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	606					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTACGCTGGCCACCACGGGCC	0.647000													11	9					0	0	0.411799	0	0
THSD7B	80731	broad.mit.edu	37	2	138425365	138425365	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:138425365T>C	ENST00000409968.1	+	27	4851	c.4673T>C	c.(4672-4674)gTt>gCt	p.V1558A	THSD7B_ENST00000413152.2_Missense_Mutation_p.V1530A|THSD7B_ENST00000272643.3_Missense_Mutation_p.V1561A					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AAAATTTGGGTTTATGGCGTT	0.358000													6	1					0	0	0.278610	0	0
ZNF829	374899	broad.mit.edu	37	19	37399336	37399336	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:37399336G>A	ENST00000520965.1	-	4	431	c.365C>T	c.(364-366)tCc>tTc	p.S122F	ZNF829_ENST00000391711.3_Missense_Mutation_p.S41F|ZNF345_ENST00000432005.2_Intron	NM_001171979.1	NP_001165450.1	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	41					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAAGTCTATGGAAACATCCCT	0.438000													31	22					0	0	0.804634	0	0
EGR4	1961	broad.mit.edu	37	2	73518772	73518772	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:73518772A>G	ENST00000436467.2	-	2	1661	c.1274T>C	c.(1273-1275)cTc>cCc	p.L425P	EGR4_ENST00000545030.1_Missense_Mutation_p.L528P			B7ZKU3	B7ZKU3_HUMAN	early growth response 4	424						intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						GTGCGTGGTGAGGTGGTCGCT	0.662000													21	35					0	0	0.706142	0	0
STOX2	56977	broad.mit.edu	37	4	184930405	184930405	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:184930405C>T	ENST00000308497.4	+	3	1849	c.414C>T	c.(412-414)atC>atT	p.I138I	STOX2_ENST00000438269.1_Silent_p.I138I	NM_020225.1	NP_064610.1	Q9P2F5	STOX2_HUMAN	storkhead box 2	138					embryo development|maternal placenta development					breast(1)|endometrium(7)|lung(6)	14		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		GCTACTTCATCGTGACCCCAC	0.493000													7	9					0	0	0.278610	0	0
CDH8	1006	broad.mit.edu	37	16	61687817	61687817	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:61687817C>T	ENST00000577390.1	-	12	3049	c.2095G>A	c.(2095-2097)Gat>Aat	p.D699N	CDH8_ENST00000577730.1_Intron|CDH8_ENST00000299345.6_Missense_Mutation_p.D699N	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	699					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.D699Y(1)		biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GGTTTAATATCCTTACGGGGT	0.428000													42	22					0	0	0.853193	0	0
OR2F2	135948	broad.mit.edu	37	7	143632997	143632997	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:143632997C>T	ENST00000408955.2	+	1	739	c.672C>T	c.(670-672)acC>acT	p.T224T		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	224					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T224K(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					TCATCTCCACCATCCTAAAGA	0.507000													25	49					0	0	0.760397	0	0
GALNT13	114805	broad.mit.edu	37	2	155099270	155099270	+	Missense_Mutation	SNP	A	A	T	rs149581963	byFrequency	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:155099270A>T	ENST00000392825.3	+	6	1105	c.538A>T	c.(538-540)Att>Ttt	p.I180F	GALNT13_ENST00000409237.1_Missense_Mutation_p.I180F	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	180	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						AGTAAAAATTATTAGGATGGA	0.358000													17	12					0	0	0.608945	0	0
HECW1	23072	broad.mit.edu	37	7	43484956	43484956	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:43484956G>A	ENST00000395891.1	+	11	2790	c.2185G>A	c.(2185-2187)Gag>Aag	p.E729K	HECW1_ENST00000453890.1_Missense_Mutation_p.E729K	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	729					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CAAGATCTCCGAGAGCACGGT	0.637000													58	76					0	0	0.870114	0	0
MAGEC3	139081	broad.mit.edu	37	X	140969393	140969393	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:140969393C>T	ENST00000298296.1	+	4	720	c.720C>T	c.(718-720)tcC>tcT	p.S240S	MAGEC3_ENST00000536088.1_Intron|MAGEC3_ENST00000443323.2_Intron|MAGEC3_ENST00000448920.1_Intron	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	240	MAGE 1.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					TTGGCATTTCCCTGACAGAAG	0.478000													25	16					0	0	0.706142	0	0
TRPM7	54822	broad.mit.edu	37	15	50899415	50899415	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:50899415G>A	ENST00000313478.7	-	20	2972	c.2691C>T	c.(2689-2691)gcC>gcT	p.A897A	TRPM7_ENST00000560955.1_Silent_p.A897A	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	897					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		CTTTCTCAATGGCATAAGTAA	0.313000													19	27					0	0	0.667858	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806188	97806188	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:97806188C>T	ENST00000358642.2	+	1	172	c.172C>T	c.(172-174)Cat>Tat	p.H58Y		NM_054106.1	NP_473447.1	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC, member 2	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	28						CCCCCATCTTCATATGCCCAT	0.443000													74	139					0	0	0.870114	0	0
MYH2	4620	broad.mit.edu	37	17	10438617	10438617	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:10438617G>A	ENST00000245503.5	-	18	2424	c.2040C>T	c.(2038-2040)atC>atT	p.I680I	MYH2_ENST00000397183.2_Silent_p.I680I|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	680	Actin-binding (By similarity).|Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TCTCATTGGGGATGATACACC	0.413000													6	21					0	0	0.248553	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719075	140719075	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:140719075C>T	ENST00000394576.2	+	1	537	c.537C>T	c.(535-537)tcC>tcT	p.S179S	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCACTTCTCCCTGGACGTGC	0.562000													56	22					0	0	0.870114	0	0
IGHV4-4	28401	broad.mit.edu	37	14	106478136	106478136	+	RNA	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:106478136C>T	ENST00000390596.2	-	0	385																											ACGGCCGTGTCCGCGGCGGTC	0.607000													30	327					0	0	0.870114	0	0
GZMH	2999	broad.mit.edu	37	14	25076890	25076890	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:25076890G>A	ENST00000216338.4	-	3	311	c.267C>T	c.(265-267)atC>atT	p.I89I	RP11-104E19.1_ENST00000557736.1_RNA|GZMH_ENST00000382548.4_Silent_p.I89I|GZMH_ENST00000557220.2_Intron|RP11-104E19.1_ENST00000555300.1_RNA	NM_033423.3	NP_219491.1	P20718	GRAH_HUMAN	granzyme H (cathepsin G-like 2, protein h-CCPX)	89	Peptidase S1.				apoptosis|cytolysis|proteolysis	cytoplasm	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)	12				GBM - Glioblastoma multiforme(265;0.0267)		TTTTCACAGGGATAAACTGCT	0.532000													65	22					0	0	0.870114	0	0
BTK	695	broad.mit.edu	37	X	100626636	100626636	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:100626636G>A	ENST00000308731.7	-	4	457	c.294C>T	c.(292-294)ttC>ttT	p.F98F	BTK_ENST00000372880.1_Silent_p.F98F	NM_000061.2	NP_000052.1	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	98	PH.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			breast(4)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(25)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						AGGGATAAGGGAACCTTTCAA	0.433000									Agammaglobulinemia, X-linked				35	23					0	0	0.864702	0	0
ALPK2	115701	broad.mit.edu	37	18	56203089	56203089	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:56203089C>T	ENST00000361673.3	-	5	4543	c.4330G>A	c.(4330-4332)Gaa>Aaa	p.E1444K	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1444							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						ATTTCCGCTTCGTGGCCCATG	0.512000													11	24					0	0	0.479597	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123448281	123448281	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:123448281C>T	ENST00000529750.1	+	2	557	c.230C>T	c.(229-231)tCc>tTc	p.S77F	GRAMD1B_ENST00000322282.7_Missense_Mutation_p.S77F|GRAMD1B_ENST00000456860.2_Missense_Mutation_p.S77F	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	77						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		GGCAAGAATTCCAAGGTGAGC	0.662000											OREG0021454	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	1					0	0	0.150653	0	0
WLS	79971	broad.mit.edu	37	1	68659877	68659877	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:68659877G>A	ENST00000262348.4	-	2	393	c.140C>T	c.(139-141)tCg>tTg	p.S47L	WLS_ENST00000370976.3_Intron|WLS_ENST00000370971.1_Missense_Mutation_p.S47L|WLS_ENST00000354777.2_Missense_Mutation_p.S45L|WLS_ENST00000540432.1_Missense_Mutation_p.S47L|GNG12-AS1_ENST00000420587.1_RNA|GNG12-AS1_ENST00000413628.1_RNA	NM_024911.6	NP_079187.3	Q5T9L3	WLS_HUMAN	wntless Wnt ligand secretion mediator	47					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(4)|prostate(3)|urinary_tract(1)	20						ACATTTCACCGACATGTAGGA	0.443000													17	10					0	0	0.624587	0	0
ARSF	416	broad.mit.edu	37	X	3030310	3030310	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:3030310G>A	ENST00000381127.1	+	11	1707	c.1486G>A	c.(1486-1488)Gaa>Aaa	p.E496K	ARSF_ENST00000359361.2_Missense_Mutation_p.E496K|ARSF_ENST00000537104.1_Missense_Mutation_p.E496K	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	496						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ATGTTTCGGAGAACAGGTTAC	0.557000													23	32					0	0	0.717897	0	0
CPAMD8	27151	broad.mit.edu	37	19	17068694	17068694	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:17068694C>T	ENST00000443236.1	-	19	2417	c.2386G>A	c.(2386-2388)Gaa>Aaa	p.E796K	CPAMD8_ENST00000388925.4_3'UTR	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	749						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						ATCCATGTTTCGGGGAAGAAA	0.393000													86	67					0	0	0.870114	0	0
PAX7	5081	broad.mit.edu	37	1	18961677	18961677	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:18961677G>A	ENST00000420770.2	+	3	477	c.394G>A	c.(394-396)Gag>Aag	p.E132K	PAX7_ENST00000400661.3_Missense_Mutation_p.E132K|PAX7_ENST00000375375.3_Missense_Mutation_p.E132K	NM_001135254.1	NP_001128726.1	P23759	PAX7_HUMAN	paired box 7	132	Paired.				anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)	31		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		GTTCAGCTGGGAGATCCGGGA	0.587000			T	FOXO1A	alveolar rhabdomyosarcoma								46	21					0	0	0.870114	0	0
MFSD2A	84879	broad.mit.edu	37	1	40432817	40432817	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:40432817C>T	ENST00000372809.5	+	9	1169	c.1026C>T	c.(1024-1026)ttC>ttT	p.F342F	MFSD2A_ENST00000420632.2_Silent_p.F173F|MFSD2A_ENST00000372811.5_Silent_p.F329F|MFSD2A_ENST00000480630.1_Intron	NM_001136493.1	NP_001129965.1	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing 2A	342					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						GCAATGAATTCCAGAATCTAC	0.547000													37	17					0	0	0.870114	0	0
PPP6C	5537	broad.mit.edu	37	9	127915925	127915925	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:127915925G>A	ENST00000451402.1	-	7	887	c.667C>T	c.(667-669)Cct>Tct	p.P223S	PPP6C_ENST00000415905.1_Missense_Mutation_p.P164S|PPP6C_ENST00000373547.4_Missense_Mutation_p.P186S|PPP6C_ENST00000373546.3_Missense_Mutation_p.P39S	NM_001123355.1	NP_001116827.1	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit	186					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			NS(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(2)|ovary(1)|skin(3)	14						CCTTTATGAGGAATTTCCTGA	0.433000													26	9					0	0	0.706142	0	0
ABCA12	26154	broad.mit.edu	37	2	215855672	215855672	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:215855672G>A	ENST00000272895.7	-	24	3597	c.3378C>T	c.(3376-3378)atC>atT	p.I1126I	ABCA12_ENST00000389661.4_Silent_p.I808I	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1126					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TGAGGATCACGATGGTAACCA	0.378000													21	75					0	0	0.639603	0	0
OR51T1	401665	broad.mit.edu	37	11	4903486	4903486	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:4903486C>T	ENST00000380378.1	+	1	438	c.438C>T	c.(436-438)gcC>gcT	p.A146A	MMP26_ENST00000477339.1_Intron|OR51T1_ENST00000322049.1_Silent_p.A119A|MMP26_ENST00000380390.1_Intron	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	119					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCTGGTAGCCATGGCCTTTG	0.493000													40	18					0	0	0.870114	0	0
PSG5	5673	broad.mit.edu	37	19	43683229	43683229	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:43683229G>A	ENST00000599812.1	-	3	606	c.511C>T	c.(511-513)Cct>Tct	p.P171S	PSG5_ENST00000404580.1_Intron|PSG5_ENST00000342951.6_Intron|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000366175.3_Intron|PSG5_ENST00000407356.1_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	171	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				GAAGCCGCAGGATCACAGGTT	0.512000													26	117					0	0	0.729181	0	0
DNAH1	25981	broad.mit.edu	37	3	52404564	52404564	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:52404564C>T	ENST00000420323.2	+	40	6591	c.6330C>T	c.(6328-6330)tcC>tcT	p.S2110S		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2110					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCATCTTCTCCCTGATCTGGA	0.567000													9	14					0	0	0.361761	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319632	21319632	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:21319632C>T	ENST00000583088.1	+	3	1873	c.978C>T	c.(976-978)cgC>cgT	p.R326R	KCNJ12_ENST00000331718.5_Silent_p.R326R	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		GGGGTCACCGCTTTGAGCCCG	0.587000										Prostate(3;0.18)			13	177					0	0	0.557998	0	0
DNAH11	8701	broad.mit.edu	37	7	21646282	21646282	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:21646282C>T	ENST00000328843.6	+	20	3814	c.3783C>T	c.(3781-3783)ttC>ttT	p.F1261F	DNAH11_ENST00000409508.3_Silent_p.F1261F			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1261	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGGCAGAGTTCAGAGAGAGAT	0.338000									Kartagener syndrome				12	5					0	0	0.411799	0	0
BEND2	139105	broad.mit.edu	37	X	18221933	18221933	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:18221933C>T	ENST00000380033.4	-	5	727	c.595G>A	c.(595-597)Gaa>Aaa	p.E199K	BEND2_ENST00000380030.3_Missense_Mutation_p.E199K	NM_153346.4	NP_699177.2	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	199										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(11)|liver(1)|lung(21)|ovary(3)|prostate(1)	49						AGGTCTGCTTCCTGCAGTTCA	0.488000													45	60					0	0	0.870114	0	0
PXDNL	137902	broad.mit.edu	37	8	52321203	52321203	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:52321203C>T	ENST00000356297.4	-	17	3081	c.2981G>A	c.(2980-2982)gGa>gAa	p.G994E	PXDNL_ENST00000543296.1_Missense_Mutation_p.G994E	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	994					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AACCGTGTTTCCCTCCCAGTG	0.637000													7	5					0	0	0.307466	0	0
MPO	4353	broad.mit.edu	37	17	56352921	56352921	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:56352921G>A	ENST00000340482.3	-	7	1619	c.1443C>T	c.(1441-1443)atC>atT	p.I481I	MPO_ENST00000225275.3_Silent_p.I449I			P05164	PERM_HUMAN	myeloperoxidase	449					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	TGGCCCCCACGATCTTCCGGG	0.602000													17	36					0	0	0.575678	0	0
COL3A1	1281	broad.mit.edu	37	2	189875410	189875410	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:189875410C>T	ENST00000304636.3	+	50	4218	c.4048C>T	c.(4048-4050)Ctt>Ttt	p.L1350F	COL3A1_ENST00000317840.5_Missense_Mutation_p.L1047F	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1350	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TGAAGATGTCCTTGATGTGCA	0.438000													9	108					0	0	0.779181	0	0
ZMAT1	84460	broad.mit.edu	37	X	101138892	101138892	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:101138892G>A	ENST00000372782.3	-	7	1554	c.1507C>T	c.(1507-1509)Cag>Tag	p.Q503*	ZMAT1_ENST00000540921.1_Nonsense_Mutation_p.Q503*|ZMAT1_ENST00000494068.1_5'UTR|ZMAT1_ENST00000458570.1_Nonsense_Mutation_p.Q332*	NM_001011657.3	NP_001011657.2	A7MD47	A7MD47_HUMAN	zinc finger, matrin-type 1	332						nucleus	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22						TTTTCTTGCTGATTAAGGCTC	0.408000													4	8					0	0	0.248553	0	0
CSF3R	1441	broad.mit.edu	37	1	36932012	36932012	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:36932012G>A	ENST00000373103.1	-	17	3085	c.2538C>T	c.(2536-2538)ttC>ttT	p.F846F	CSF3R_ENST00000361632.4_Silent_p.F819F|CSF3R_ENST00000487540.2_5'UTR|CSF3R_ENST00000418048.2_Silent_p.F819F|CSF3R_ENST00000338937.5_3'UTR|CSF3R_ENST00000373104.1_Intron|CSF3R_ENST00000373106.1_Silent_p.F819F|CSF3R_ENST00000440588.2_Silent_p.F846F|CSF3R_ENST00000331941.5_Intron	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	819					cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	GCAGGAGGGGGAAGTTGAGCA	0.632000													8	5					0	0	0.387290	0	0
LTBP4	8425	broad.mit.edu	37	19	41113412	41113412	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:41113412A>T	ENST00000308370.7	+	10	1334	c.1334A>T	c.(1333-1335)cAg>cTg	p.Q445L	LTBP4_ENST00000204005.9_Missense_Mutation_p.Q408L|LTBP4_ENST00000545697.1_5'UTR|LTBP4_ENST00000602240.1_3'UTR|LTBP4_ENST00000396819.3_Missense_Mutation_p.Q378L	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	445	TB 2.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CGGGGCTGCCAGCTCTGCCCA	0.662000													12	4					0	0	0.500413	0	0
FAM135B	51059	broad.mit.edu	37	8	139165169	139165169	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:139165169C>T	ENST00000395297.1	-	13	1719	c.1549G>A	c.(1549-1551)Gaa>Aaa	p.E517K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	517										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GTCCAACATTCATCTTCAGGC	0.458000										HNSCC(54;0.14)			60	68					0	0	0.870114	0	0
ZBTB41	360023	broad.mit.edu	37	1	197128925	197128925	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:197128925G>A	ENST00000367405.4	-	10	2362	c.2294C>T	c.(2293-2295)tCc>tTc	p.S765F	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	765					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						AACTGGCAAGGATACAAGTTT	0.383000													96	27					0	0	0.870114	0	0
OR10T2	128360	broad.mit.edu	37	1	158368942	158368942	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:158368942G>A	ENST00000334438.1	-	1	314	c.315C>T	c.(313-315)ttC>ttT	p.F105F		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					CAAAGCCAAGGAAAAAGAACA	0.498000													38	13					0	0	0.827153	0	0
ZDHHC19	131540	broad.mit.edu	37	3	195936311	195936311	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:195936311G>A	ENST00000296326.3	-	3	423	c.344C>T	c.(343-345)cCa>cTa	p.P115L	ZDHHC19_ENST00000488508.1_5'UTR	NM_001039617.1	NP_001034706.1	Q8WVZ1	ZDH19_HUMAN	zinc finger, DHHC-type containing 19	115						integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(7)|ovary(3)	14	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.89e-25)|all cancers(36;1.46e-23)|OV - Ovarian serous cystadenocarcinoma(49;2.1e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0022)		GCAGCACTTTGGACACCATTG	0.657000													8	13					0	0	0.361761	0	0
MYH2	4620	broad.mit.edu	37	17	10429959	10429959	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:10429959C>T	ENST00000245503.5	-	30	4528	c.4144G>A	c.(4144-4146)Gag>Aag	p.E1382K	CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.E1382K|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1382					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GCGTCCGTCTCGTATTTGGTC	0.532000													91	91					0	0	0.870114	0	0
ABCB5	340273	broad.mit.edu	37	7	20687681	20687681	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:20687681C>T	ENST00000404938.2	+	11	1838	c.1186C>T	c.(1186-1188)Cca>Tca	p.P396S	ABCB5_ENST00000258738.6_5'UTR|ABCB5_ENST00000443026.2_5'UTR|ABCB5_ENST00000406935.1_5'UTR|ABCB5_ENST00000477094.1_3'UTR	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	580	ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						TTTCAATTATCCATCAAGACC	0.338000													12	3					0	0	0.479597	0	0
GABRQ	55879	broad.mit.edu	37	X	151818907	151818907	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:151818907G>A	ENST00000370306.2	+	7	785	c.765G>A	c.(763-765)ctG>ctA	p.L255L		NM_018558.2	NP_061028.2	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) A receptor, theta	255						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					ACATACGCCTGATACTGAAGT	0.517000													16	147					0	0	0.575678	0	0
GCA	25801	broad.mit.edu	37	2	163204218	163204218	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:163204218C>T	ENST00000437150.2	+	2	319	c.158C>T	c.(157-159)tCc>tTc	p.S53F	GCA_ENST00000473240.1_3'UTR|GCA_ENST00000429691.2_Missense_Mutation_p.S34F|GCA_ENST00000233612.4_Missense_Mutation_p.S34F	NM_012198.3	NP_036330.1	P28676	GRAN_HUMAN	grancalcin, EF-hand calcium binding protein	53	EF-hand 1.				cellular membrane fusion	cytoplasm|plasma membrane	calcium ion binding|protein homodimerization activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|lung(4)|ovary(1)	9						GCTGGTGACTCCGTGTATACT	0.423000													24	37					0	0	0.717897	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110453598	110453598	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:110453598G>A	ENST00000378402.5	+	34	4298	c.4194G>A	c.(4192-4194)ggG>ggA	p.G1398G		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1398	IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CCAACAATGGGAAAGATTCAG	0.289000										HNSCC(38;0.096)			5	5					0	0	0.248553	0	0
NES	10763	broad.mit.edu	37	1	156639850	156639850	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:156639850G>A	ENST00000368223.3	-	4	4262	c.4130C>T	c.(4129-4131)cCt>cTt	p.P1377L		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1377	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity	p.P1377H(1)		central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGGAAGAAAAGGTGCCTCAGT	0.617000													22	5					0	0	0.667858	0	0
KCNK7	10089	broad.mit.edu	37	11	65363008	65363008	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:65363008G>A	ENST00000394216.2	-	1	459	c.236C>T	c.(235-237)tCc>tTc	p.S79F	KCNK7_ENST00000340313.4_Missense_Mutation_p.S79F|KCNK7_ENST00000394217.2_Missense_Mutation_p.S79F|KCNK7_ENST00000342202.4_Missense_Mutation_p.S79F	NM_005714.1|NM_033455.1	NP_005705.1|NP_258416.1	Q9Y2U2	KCNK7_HUMAN	potassium channel, subfamily K, member 7	79						integral to membrane	potassium channel activity|voltage-gated ion channel activity			endometrium(1)|liver(1)|lung(1)	3						GCCCAGGGTGGAGACCCCATG	0.667000													9	2					0	0	0.387290	0	0
TMEM35	59353	broad.mit.edu	37	X	100349862	100349862	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:100349862G>A	ENST00000372930.4	+	2	704	c.421G>A	c.(421-423)Gag>Aag	p.E141K	TMEM35_ENST00000478351.1_3'UTR	NM_021637.2	NP_067650.1	Q53FP2	TMM35_HUMAN	transmembrane protein 35	141						cytoplasmic membrane-bounded vesicle|integral to membrane|peroxisomal membrane				NS(1)|large_intestine(3)|liver(1)|skin(1)|urinary_tract(1)	7						CCGGTCTTCTGAGAAGAAGCC	0.537000													19	24					0	0	0.624587	0	0
FCN2	2220	broad.mit.edu	37	9	137778323	137778323	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:137778323C>T	ENST00000350339.2	+	6	507	c.493C>T	c.(493-495)Cag>Tag	p.Q165*	FCN2_ENST00000291744.6_Nonsense_Mutation_p.Q203*	NM_015837.2	NP_056652.1	Q15485	FCN2_HUMAN	ficolin (collagen/fibrinogen domain containing lectin) 2	203	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	20		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		GGACAACTACCAGTTTGCTAA	0.547000													55	24					0	0	0.870114	0	0
KIF23	9493	broad.mit.edu	37	15	69732339	69732339	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:69732339T>C	ENST00000260363.4	+	16	1927	c.1810T>C	c.(1810-1812)Ttt>Ctt	p.F604L	KIF23_ENST00000352331.4_Missense_Mutation_p.F604L|KIF23_ENST00000559279.1_Missense_Mutation_p.F604L|KIF23_ENST00000537891.1_Missense_Mutation_p.F421L|KIF23_ENST00000395392.2_Missense_Mutation_p.F604L|KIF23_ENST00000558585.1_Missense_Mutation_p.F421L	NM_138555.2	NP_612565.1	Q02241	KIF23_HUMAN	kinesin family member 23	604					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(6)|prostate(2)|skin(1)	21						TCAGCGACAGTTTTCTGACAA	0.408000													8	27					0	0	0.278610	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60242640	60242640	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:60242640C>T	ENST00000269499.5	+	13	3744	c.3326C>T	c.(3325-3327)cCt>cTt	p.P1109L	ZCCHC2_ENST00000586834.1_Missense_Mutation_p.P788L	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	1109					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						AGATTCTATCCTGTATATCCA	0.493000													8	12					0	0	0.335167	0	0
ZNF711	7552	broad.mit.edu	37	X	84526097	84526097	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:84526097C>T	ENST00000360700.4	+	10	2573	c.1687C>T	c.(1687-1689)Cct>Tct	p.P563S	ZNF711_ENST00000395402.1_Missense_Mutation_p.P525S|ZNF711_ENST00000276123.3_Missense_Mutation_p.P517S|ZNF711_ENST00000542798.1_Missense_Mutation_p.P359S|ZNF711_ENST00000373165.3_Missense_Mutation_p.P517S			Q9Y462	ZN711_HUMAN	zinc finger protein 711	517					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						TTTTCGACATCCTTCTGAACT	0.408000													16	19					0	0	0.592651	0	0
SNORD115-44	100033818	broad.mit.edu	37	15	25496072	25496072	+	RNA	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:25496072G>A	ENST00000365391.1	+	0	67					NR_003359.1																						TGCTCAATAGGATTACGCTGA	0.527000													74	211					0	0	0.870114	0	0
WFDC8	90199	broad.mit.edu	37	20	44187613	44187613	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:44187613G>A	ENST00000357199.4	-	3	233	c.155C>T	c.(154-156)cCc>cTc	p.P52L	WFDC8_ENST00000289953.2_Missense_Mutation_p.P52L	NM_181510.2	NP_852611.2	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8	52	WAP 1.					extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|stomach(1)|upper_aerodigestive_tract(1)	15		Myeloproliferative disorder(115;0.0122)				CCTCTCTTTGGGACATAACCC	0.428000													29	107					0	0	0.819951	0	0
DENND3	22898	broad.mit.edu	37	8	142166030	142166030	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:142166030C>T	ENST00000519811.1	+	8	1227	c.1157C>T	c.(1156-1158)cCt>cTt	p.P386L	DENND3_ENST00000424248.1_Missense_Mutation_p.P306L|DENND3_ENST00000262585.2_Missense_Mutation_p.P306L			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	306	dDENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GTGGACATTCCTGATGTCCCC	0.448000													42	51					0	0	0.870114	0	0
FAT3	120114	broad.mit.edu	37	11	92085966	92085966	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:92085966G>A	ENST00000298047.6	+	1	705	c.688G>A	c.(688-690)Gaa>Aaa	p.E230K	FAT3_ENST00000525166.1_Missense_Mutation_p.E80K|FAT3_ENST00000541502.1_Missense_Mutation_p.E230K|FAT3_ENST00000409404.2_Missense_Mutation_p.E230K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	230	Cadherin 2.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTATGATCTGGAAATTTTGGC	0.393000										TCGA Ovarian(4;0.039)			35	65					0	0	0.819951	0	0
SLC12A6	9990	broad.mit.edu	37	15	34551109	34551109	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:34551109G>A	ENST00000354181.3	-	5	940	c.448C>T	c.(448-450)Ctc>Ttc	p.L150F	SLC12A6_ENST00000451844.2_Missense_Mutation_p.L11F|SLC12A6_ENST00000458406.2_Missense_Mutation_p.L91F|SLC12A6_ENST00000558589.1_Missense_Mutation_p.L141F|SLC12A6_ENST00000397707.2_Missense_Mutation_p.L135F|SLC12A6_ENST00000558667.1_Missense_Mutation_p.L150F|SLC12A6_ENST00000560611.1_Missense_Mutation_p.L150F|SLC12A6_ENST00000290209.5_Missense_Mutation_p.L99F|SLC12A6_ENST00000560164.1_Missense_Mutation_p.L11F|SLC12A6_ENST00000397702.2_Missense_Mutation_p.L91F			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	150					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	ATGCGGTTGAGGAGGGAAGAC	0.433000													11	26					0	0	0.411799	0	0
MUTYH	4595	broad.mit.edu	37	1	45797205	45797205	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:45797205A>G	ENST00000450313.1	-	13	1425	c.1210T>C	c.(1210-1212)Ttc>Ctc	p.F404L	MUTYH_ENST00000372098.3_Missense_Mutation_p.F401L|MUTYH_ENST00000531105.1_Intron|MUTYH_ENST00000372104.1_Missense_Mutation_p.F376L|MUTYH_ENST00000372110.3_Missense_Mutation_p.F391L|MUTYH_ENST00000372115.3_Missense_Mutation_p.F390L|MUTYH_ENST00000355498.2_Missense_Mutation_p.F376L|MUTYH_ENST00000448481.1_Missense_Mutation_p.F387L|MUTYH_ENST00000529984.1_Missense_Mutation_p.F71L|MUTYH_ENST00000456914.2_Missense_Mutation_p.F376L|MUTYH_ENST00000372100.5_Missense_Mutation_p.F387L|MUTYH_ENST00000488731.2_Missense_Mutation_p.F71L|MUTYH_ENST00000528332.2_Missense_Mutation_p.F85L|MUTYH_ENST00000354383.6_Missense_Mutation_p.F377L	NM_001128425.1|NM_012222.2	NP_001121897.1|NP_036354.1	Q9UIF7	MUTYH_HUMAN	mutY homolog	401	Nudix hydrolase.				depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					ACGGACGGGAACTCCCACAGT	0.652000			Mis			colorectal		Base excision repair (BER), DNA glycosylases	MUTYH-associated polyposis				20	3					0	0	0.624587	0	0
TNFRSF10D	8793	broad.mit.edu	37	8	23003370	23003370	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:23003370C>T	ENST00000312584.3	-	5	641	c.547G>A	c.(547-549)Gaa>Aaa	p.E183K		NM_003840.4	NP_003831.2	Q9UBN6	TR10D_HUMAN	tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain	183					anti-apoptosis|apoptosis	integral to membrane	TRAIL binding|transmembrane receptor activity			endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		GCAGCTGATTCATTTTTGCAC	0.532000													52	46					0	0	0.870114	0	0
PDE3A	5139	broad.mit.edu	37	12	20786684	20786684	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:20786684G>A	ENST00000359062.3	+	7	1858	c.1818G>A	c.(1816-1818)ggG>ggA	p.G606G	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	606					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	AGAGAAGTGGGGTAGCCACTC	0.433000													15	20					0	0	0.592651	0	0
CHL1	10752	broad.mit.edu	37	3	432737	432737	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:432737C>T	ENST00000256509.2	+	22	3328	c.2686C>T	c.(2686-2688)Cct>Tct	p.P896S	CHL1_ENST00000397491.2_Missense_Mutation_p.P880S	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	880	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TGGAATGGTTCCTTCCTTAGA	0.368000													19	27					0	0	0.575678	0	0
OXLD1	339229	broad.mit.edu	37	17	79632478	79632478	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:79632478G>A	ENST00000374741.3	-	2	207	c.197C>T	c.(196-198)tCc>tTc	p.S66F	OXLD1_ENST00000573786.1_5'UTR|OXLD1_ENST00000571503.1_3'UTR	NM_001039842.1	NP_001034931.1			oxidoreductase-like domain containing 1																		ACCTGCTTGGGAGCCCACCTC	0.642000													7	47					0	0	0.278610	0	0
PHKG1	5260	broad.mit.edu	37	7	56149604	56149604	+	Silent	SNP	C	C	T	rs145703798	byFrequency	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:56149604C>T	ENST00000452681.2	-	9	1019	c.870G>A	c.(868-870)tcG>tcA	p.S290S	PHKG1_ENST00000297373.2_Silent_p.S258S|PHKG1_ENST00000537360.1_Silent_p.S204S	NM_001258459.1	NP_001245388.1	Q16816	PHKG1_HUMAN	phosphorylase kinase, gamma 1 (muscle)	258					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			endometrium(1)|large_intestine(1)|lung(5)	7	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TCACGGTGTCCGAGTAATCAT	0.652000													8	14					0	0	0.307466	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185188	127185188	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:127185188G>A	ENST00000371124.3	-	1	1194	c.998C>T	c.(997-999)tCt>tTt	p.S333F		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	333						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						TCTATCAGGAGAAGCTGTGAT	0.527000													4	32					0	0	0.184627	0	0
CD177	57126	broad.mit.edu	37	19	43859894	43859894	+	RNA	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:43859894G>A	ENST00000378009.4	+	0	503				CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				TGCCCCAAGGGGACCACACAC	0.577000													17	17					0	0	0.575678	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960605	73960605	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:73960605G>A	ENST00000373468.1	-	3	4438	c.3787C>T	c.(3787-3789)Caa>Taa	p.Q1263*	KIAA2022_ENST00000055682.5_Nonsense_Mutation_p.Q1263*			Q5QGS0	K2022_HUMAN	KIAA2022	1263					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						CCACCATGTTGGATACATTCA	0.517000													3	6					0	0	0.150653	0	0
HECW2	57520	broad.mit.edu	37	2	197194325	197194325	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:197194325C>T	ENST00000260983.2	-	5	727	c.545G>A	c.(544-546)cGa>cAa	p.R182Q	HECW2_ENST00000409111.1_5'UTR	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	182	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						AACAAGTTTTCGAGAATGCAG	0.408000													41	61					0	0	0.870114	0	0
SCN5A	6331	broad.mit.edu	37	3	38647496	38647496	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:38647496C>T	ENST00000413689.1	-	10	1477	c.1284G>A	c.(1282-1284)gaG>gaA	p.E428E	SCN5A_ENST00000425664.1_Silent_p.E428E|SCN5A_ENST00000451551.2_Silent_p.E428E|SCN5A_ENST00000423572.2_Silent_p.E428E|SCN5A_ENST00000443581.1_Silent_p.E428E|SCN5A_ENST00000333535.4_Silent_p.E428E|SCN5A_ENST00000450102.2_Silent_p.E428E|SCN5A_ENST00000414099.2_Silent_p.E428E|SCN5A_ENST00000455624.2_Silent_p.E428E|SCN5A_ENST00000449557.2_Silent_p.E428E	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	428			E -> K (found in patients with atrial fibrillation).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TTTCCTTCTCCTCGGTCTCAG	0.562000													15	36					0	0	0.539581	0	0
TMEM209	84928	broad.mit.edu	37	7	129841883	129841883	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:129841883G>T	ENST00000397622.2	-	5	502	c.380C>A	c.(379-381)cCc>cAc	p.P127H	RP11-775D22.3_ENST00000483283.1_RNA|TMEM209_ENST00000336804.8_Missense_Mutation_p.P126H|TMEM209_ENST00000462753.1_Missense_Mutation_p.P126H|TMEM209_ENST00000473456.1_Missense_Mutation_p.P127H	NM_032842.3	NP_116231.2	Q96SK2	TM209_HUMAN	transmembrane protein 209	127						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	12	Melanoma(18;0.0435)					AGGTGGAGCGGGAGGGATTTG	0.458000													23	39					6.12954e-19	6.19389e-19	0.681144	1	0
OR14J1	442191	broad.mit.edu	37	6	29275264	29275264	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:29275264G>A	ENST00000377160.2	+	1	862	c.798G>A	c.(796-798)tcG>tcA	p.S266S		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						ATTCCTCATCGACTGTGGACC	0.458000													62	69					0	0	0.870114	0	0
TTN	7273	broad.mit.edu	37	2	179640313	179640313	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:179640313G>A	ENST00000589042.1	-	28	6502	c.6278C>T	c.(6277-6279)tCt>tTt	p.S2093F	TTN_ENST00000342175.6_Missense_Mutation_p.S2047F|TTN_ENST00000342992.6_Missense_Mutation_p.S2093F|TTN_ENST00000591111.1_Missense_Mutation_p.S2093F|TTN_ENST00000460472.2_Missense_Mutation_p.S2047F|TTN_ENST00000360870.5_Missense_Mutation_p.S2093F|TTN_ENST00000359218.5_Missense_Mutation_p.S2047F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1856	Ig-like 10.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGTGCATCAGATCCTTGGCC	0.463000													17	25					0	0	0.608945	0	0
HYKK	123688	broad.mit.edu	37	15	78819789	78819789	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:78819789C>T	ENST00000566332.1	+	4	605	c.545C>T	c.(544-546)cCt>cTt	p.P182L	HYKK_ENST00000408962.2_Missense_Mutation_p.P182L|HYKK_ENST00000388988.4_Missense_Mutation_p.P182L|HYKK_ENST00000569878.1_Missense_Mutation_p.P182L|HYKK_ENST00000563233.1_Missense_Mutation_p.P182L					hydroxylysine kinase																		AAAAATGTTCCTCTTCTGGAG	0.403000													46	58					0	0	0.870114	0	0
OR5T2	219464	broad.mit.edu	37	11	56000318	56000318	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:56000318A>C	ENST00000313264.4	-	1	419	c.344T>G	c.(343-345)gTt>gGt	p.V115G		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					TGGGGTAATAACTGAGGAATA	0.388000													23	14					0	0	0.667858	0	0
PTPRK	5796	broad.mit.edu	37	6	128505788	128505788	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:128505788G>A	ENST00000368227.3	-	7	1317	c.951C>T	c.(949-951)atC>atT	p.I317I	PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368213.5_Silent_p.I317I|PTPRK_ENST00000532331.1_Silent_p.I317I|PTPRK_ENST00000368215.3_Silent_p.I317I|PTPRK_ENST00000368226.4_Silent_p.I317I|PTPRK_ENST00000368210.3_Silent_p.I317I|PTPRK_ENST00000368207.3_Silent_p.I317I			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	317	Fibronectin type-III 1.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CATCGCCAATGATCGAGTTGG	0.463000													36	70					0	0	0.769981	0	0
FOXD4	2298	broad.mit.edu	37	9	116808	116808	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:116808G>A	ENST00000382500.2	-	1	1609	c.1312C>T	c.(1312-1314)Ccc>Tcc	p.P438S		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	438					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CTCTAGGAGGGCCCTGCGGAC	0.657000													5	12					0	0	0.184627	0	0
CDH13	1012	broad.mit.edu	37	16	83636115	83636115	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:83636115G>A	ENST00000566620.1	+	8	1307	c.1017G>A	c.(1015-1017)ctG>ctA	p.L339L	CDH13_ENST00000428848.3_Silent_p.L300L|CDH13_ENST00000268613.10_Silent_p.L386L	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	339	Cadherin 2.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TGGCTGGACTGGATGTTGGAT	0.423000													11	183					0	0	0.435327	0	0
SPICE1	152185	broad.mit.edu	37	3	113212090	113212090	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:113212090G>A	ENST00000295872.4	-	6	714	c.455C>T	c.(454-456)aCc>aTc	p.T152I		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	152					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						GATAGATTGGGTGATAGGGTC	0.413000													18	41					0	0	0.654019	0	0
ISY1-RAB43	100534599	broad.mit.edu	37	3	128813986	128813986	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:128813986C>T	ENST00000418265.1	-	12	938	c.878G>A	c.(877-879)aGg>aAg	p.R293K	RAB43_ENST00000393307.1_Silent_p.Q77Q|RAB43_ENST00000393308.1_Silent_p.Q77Q|RAB43_ENST00000315150.5_Silent_p.Q77Q|RAB43_ENST00000393304.1_Silent_p.Q77Q|RAB43_ENST00000393305.1_Silent_p.Q77Q|RAB43_ENST00000476465.1_Silent_p.Q77Q	NM_001204890.1	NP_001191819.1	Q9ULR0	ISY1_HUMAN		0						catalytic step 2 spliceosome											GGAACCGCTCCTGGCCGGCCG	0.592000													14	28					0	0	0.608945	0	0
C1orf173	127254	broad.mit.edu	37	1	75037994	75037994	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:75037994C>T	ENST00000326665.5	-	14	3618	c.3400G>A	c.(3400-3402)Gct>Act	p.A1134T	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1134	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AACTCAGAAGCCTCCACAGGT	0.468000													12	9					0	0	0.457914	0	0
KCNH5	27133	broad.mit.edu	37	14	63453898	63453898	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:63453898C>T	ENST00000322893.7	-	5	709	c.441G>A	c.(439-441)acG>acA	p.T147T	KCNH5_ENST00000394968.1_Silent_p.T89T|KCNH5_ENST00000420622.2_Silent_p.T147T|KCNH5_ENST00000394964.2_Silent_p.T89T	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	147					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GGGCAAATTTCGTCCAACCTT	0.388000													28	11					0	0	0.717897	0	0
ATP2B2	491	broad.mit.edu	37	3	10392084	10392084	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:10392084C>T	ENST00000397077.1	-	14	2754	c.2179G>A	c.(2179-2181)Gag>Aag	p.E727K	ATP2B2_ENST00000383800.4_Missense_Mutation_p.E727K|ATP2B2_ENST00000352432.4_Missense_Mutation_p.E772K|ATP2B2_ENST00000343816.4_Missense_Mutation_p.E758K|ATP2B2_ENST00000360273.2_Missense_Mutation_p.E772K			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	772					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						ACACGCACCTCCCCCTTCTCG	0.587000													19	49					0	0	0.575678	0	0
PHYH	5264	broad.mit.edu	37	10	13325836	13325836	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr10:13325836C>T	ENST00000396920.3	-	7	1035	c.631G>A	c.(631-633)Gga>Aga	p.G211R	PHYH_ENST00000396913.2_Missense_Mutation_p.G128R|PHYH_ENST00000263038.4_Missense_Mutation_p.G228R			O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase	228					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	25		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	TTGTTAACTCCCCCCTAGAAC	0.458000													95	61					0	0	0.870114	0	0
SNX17	9784	broad.mit.edu	37	2	27596815	27596815	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:27596815G>A	ENST00000233575.2	+	5	631	c.409G>A	c.(409-411)Gat>Aat	p.D137N	SNX17_ENST00000543024.1_5'UTR|SNX17_ENST00000537606.1_Missense_Mutation_p.D112N|SNX17_ENST00000542478.1_5'UTR	NM_001267059.1|NM_001267061.1|NM_014748.3	NP_001253988.1|NP_001253990.1|NP_055563.1	Q15036	SNX17_HUMAN	sorting nexin 17	137	Ras-associating.				cell communication|endosome transport|intracellular protein transport|regulation of endocytosis|signal transduction	cytoplasmic vesicle membrane|cytosol|early endosome|Golgi apparatus	low-density lipoprotein particle receptor binding|phosphatidylinositol binding|protein C-terminus binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTAACTTCAGATCAGACTGA	0.557000													34	22					0	0	0.812448	0	0
SAMD9	54809	broad.mit.edu	37	7	92731309	92731309	+	Missense_Mutation	SNP	C	C	T	rs138600971	byFrequency	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:92731309C>T	ENST00000379958.2	-	3	4371	c.4102G>A	c.(4102-4104)Gaa>Aaa	p.E1368K		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1368						cytoplasm		p.E1368K(1)		NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			AAAGTATATTCGTTCACTATA	0.348000													36	45					0	0	0.827153	0	0
LYRM4	57128	broad.mit.edu	37	6	5216856	5216856	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:5216856G>A	ENST00000330636.4	-	2	407	c.202C>T	c.(202-204)Cga>Tga	p.R68*	LYRM4_ENST00000480566.1_Nonsense_Mutation_p.R68*|LYRM4_ENST00000464010.1_Nonsense_Mutation_p.R68*|LYRM4_ENST00000468929.1_Intron|LYRM4_ENST00000500576.2_Nonsense_Mutation_p.R68*	NM_020408.4	NP_065141.3	Q9HD34	LYRM4_HUMAN	LYR motif containing 4	68						mitochondrion|nucleus				endometrium(1)	1	Ovarian(93;0.11)	all_hematologic(90;0.0901)				CTTACCTGTCGACGAATTACT	0.383000													18	90					0	0	0.654019	0	0
CD177	57126	broad.mit.edu	37	19	43866411	43866411	+	RNA	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:43866411G>A	ENST00000378009.4	+	0	1414				CD177_ENST00000607517.1_RNA|CTC-490G23.4_ENST00000607109.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				TCTCTCACTTGGGGGGTGGGG	0.617000													8	5					0	0	0.335167	0	0
IFFO1	25900	broad.mit.edu	37	12	6665123	6665123	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:6665123C>T	ENST00000336604.4	-	1	114	c.73G>A	c.(73-75)Gac>Aac	p.D25N	IFFO1_ENST00000356896.4_Missense_Mutation_p.D25N|IFFO1_ENST00000396840.2_Missense_Mutation_p.D25N	NM_080730.4	NP_542768.2	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan 1	25						intermediate filament				central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	20						CCCAGTGAGTCCCCCAGTGGC	0.716000													5	4					0	0	0.217242	0	0
LPCAT4	254531	broad.mit.edu	37	15	34656416	34656416	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:34656416G>A	ENST00000314891.6	-	4	747	c.570C>T	c.(568-570)acC>acT	p.T190T		NM_153613.2	NP_705841.2	Q643R3	LPCT4_HUMAN	lysophosphatidylcholine acyltransferase 4	190					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|calcium ion binding			NS(1)|breast(1)|large_intestine(2)|lung(5)|prostate(1)	10						TGCCTCCTGAGGTGGCCCGCC	0.592000													81	107					0	0	0.870114	0	0
RNF207	388591	broad.mit.edu	37	1	6273205	6273205	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:6273205C>T	ENST00000377939.4	+	16	1741	c.1614C>T	c.(1612-1614)gtC>gtT	p.V538V	RNF207_ENST00000483336.1_3'UTR|RNF207_ENST00000377948.2_3'UTR	NM_207396.2	NP_997279.2	Q6ZRF8	RN207_HUMAN	ring finger protein 207	538						intracellular	zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(2)	16	Ovarian(185;0.0634)	all_cancers(23;1.22e-38)|all_epithelial(116;4.25e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.84e-38)|GBM - Glioblastoma multiforme(13;5.77e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.88e-19)|Colorectal(212;6.9e-08)|COAD - Colon adenocarcinoma(227;8.13e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		CGCCCTACGTCCGCTCCATTG	0.627000													28	9					0	0	0.760397	0	0
MINK1	50488	broad.mit.edu	37	17	4788861	4788861	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:4788861G>A	ENST00000355280.6	+	7	788	c.592G>A	c.(592-594)Gag>Aag	p.E198K	MINK1_ENST00000347992.7_Missense_Mutation_p.E198K|MINK1_ENST00000453408.3_Missense_Mutation_p.E198K	NM_001024937.3|NM_015716.4|NM_153827.4	NP_001020108.1|NP_056531.1|NP_722549.2	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1	198	Protein kinase.				JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						GATGGCTCCAGAGGTCATCGC	0.557000													26	63					0	0	0.717897	0	0
DENND4B	9909	broad.mit.edu	37	1	153906074	153906074	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:153906074G>T	ENST00000361217.4	-	20	3633	c.3215C>A	c.(3214-3216)cCt>cAt	p.P1072H		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	1072										NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCGGGAGGCAGGGGAGTGGCG	0.721000													16	4					1.87028e-06	1.8776e-06	0.608945	1	0
DNAH5	1767	broad.mit.edu	37	5	13862838	13862838	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:13862838C>T	ENST00000265104.4	-	29	4719	c.4615G>A	c.(4615-4617)Gtg>Atg	p.V1539M	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1539	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTCTCTTTCACCGCACTGATA	0.428000									Kartagener syndrome				55	29					0	0	0.870114	0	0
SIRPB1	10326	broad.mit.edu	37	20	1552409	1552409	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:1552409C>T	ENST00000381605.4	-	3	772	c.708G>A	c.(706-708)ggG>ggA	p.G236G	SIRPB1_ENST00000381603.3_Intron|RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000262929.5_Intron	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	236	Ig-like C1-type 1.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						GAAGAGGGTCCCCCTGCAAGG	0.612000													22	88					0	0	0.667858	0	0
CD163	9332	broad.mit.edu	37	12	7639227	7639227	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:7639227C>T	ENST00000359156.4	-	10	2528	c.2326G>A	c.(2326-2328)Gaa>Aaa	p.E776K	CD163_ENST00000396620.3_Missense_Mutation_p.E809K|CD163_ENST00000541972.1_Missense_Mutation_p.E764K|CD163_ENST00000432237.2_Missense_Mutation_p.E776K	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	776	SRCR 7.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						CCTGTTCCTTCCCCAAAATGA	0.537000													10	244					0	0	0.457914	0	0
EPHA1	2041	broad.mit.edu	37	7	143095045	143095045	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:143095045G>A	ENST00000275815.3	-	8	1669	c.1583C>T	c.(1582-1584)tCc>tTc	p.S528F		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	528	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				ATGATCAGGGGAGAAAGGGCC	0.567000													30	58					0	0	0.796494	0	0
LRRTM4	80059	broad.mit.edu	37	2	77746532	77746532	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:77746532C>T	ENST00000409088.3	-	3	877	c.463G>A	c.(463-465)Ggc>Agc	p.G155S	LRRTM4_ENST00000409884.1_Missense_Mutation_p.G155S|LRRTM4_ENST00000409911.1_Missense_Mutation_p.G156S|LRRTM4_ENST00000409282.1_Missense_Mutation_p.G156S|LRRTM4_ENST00000409093.1_Missense_Mutation_p.G155S	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	155						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		TTCCGAAGGCCTTTAAATTGT	0.383000													30	18					0	0	0.717897	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140797886	140797886	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:140797886C>T	ENST00000398594.2	+	1	460	c.460C>T	c.(460-462)Ctt>Ttt	p.L154F	PCDHGA10_ENST00000398610.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAACAATTCTTGAGTCTGC	0.418000													13	5					0	0	0.479597	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144061036	144061036	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:144061036C>T	ENST00000056217.5	+	2	1448	c.1274C>T	c.(1273-1275)gCc>gTc	p.A425V		NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5	425					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					TTTCCAGGTGCCTCATATCTC	0.582000													21	27					0	0	0.624587	0	0
TRRAP	8295	broad.mit.edu	37	7	98573802	98573802	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:98573802C>T	ENST00000359863.4	+	53	8058	c.7849C>T	c.(7849-7851)Ctg>Ttg	p.L2617L	TRRAP_ENST00000355540.3_Silent_p.L2599L|TRRAP_ENST00000446306.3_Silent_p.L2599L	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	2617					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TTTCGTTCAGCTGTGCCACAT	0.562000													25	41					0	0	0.654019	0	0
LGSN	51557	broad.mit.edu	37	6	63990433	63990433	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:63990433C>T	ENST00000370658.5	-	5	635	c.602G>A	c.(601-603)gGa>gAa	p.G201E	LGSN_ENST00000370657.4_Silent_p.G341G	NM_001143940.1|NM_016571.2	NP_001137412.1|NP_057655.2	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	0					glutamine biosynthetic process		glutamate-ammonia ligase activity	p.G341G(1)		NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	ACCATTTTTTCCCAGTGATCG	0.488000													13	32					0	0	0.557998	0	0
IL1A	3552	broad.mit.edu	37	2	113541312	113541312	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:113541312C>T	ENST00000263339.3	-	2	191	c.36G>A	c.(34-36)aaG>aaA	p.K12K		NM_000575.3	NP_000566.3	P01583	IL1A_HUMAN	interleukin 1, alpha	12					anti-apoptosis|apoptosis|cell proliferation|cellular response to heat|cytokine-mediated signaling pathway|fever generation|immune response|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation vascular endothelial growth factor production|response to copper ion	cytosol|extracellular space	copper ion binding|cytokine activity|interleukin-1 receptor binding			breast(2)|large_intestine(1)|lung(9)	12						TGTAACAGTTCTTCAGGTCTT	0.463000													15	70					0	0	0.557998	0	0
JARID2	3720	broad.mit.edu	37	6	15496653	15496653	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:15496653C>T	ENST00000341776.2	+	7	1441	c.1197C>T	c.(1195-1197)tcC>tcT	p.S399S	JARID2_ENST00000541660.1_Silent_p.S361S|JARID2_ENST00000397311.3_Silent_p.S227S	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	399					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CGTCCAAGTCCACTGGGCCCG	0.602000													58	79					0	0	0.870114	0	0
FAM47B	170062	broad.mit.edu	37	X	34961323	34961323	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:34961323G>A	ENST00000329357.5	+	1	411	c.375G>A	c.(373-375)ctG>ctA	p.L125L		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	125										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						AAGCCCAGCTGATGACCAAGC	0.542000													6	48					0	0	0.278610	0	0
EPB41L1	2036	broad.mit.edu	37	20	34802352	34802352	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr20:34802352C>T	ENST00000338074.2	+	17	2419	c.2258C>T	c.(2257-2259)tCg>tTg	p.S753L	EPB41L1_ENST00000373950.2_Missense_Mutation_p.S644L|EPB41L1_ENST00000373946.3_Missense_Mutation_p.S573L|EPB41L1_ENST00000373941.1_Missense_Mutation_p.S752L|EPB41L1_ENST00000202028.5_Intron|EPB41L1_ENST00000441639.1_Intron	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	753	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					GAGACCATATCGACCACCATG	0.572000													8	21					0	0	0.335167	0	0
SPANXD	64648	broad.mit.edu	37	X	140785720	140785720	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:140785720C>T	ENST00000370515.3	-	2	529	c.196G>A	c.(196-198)Gaa>Aaa	p.E66K		NM_032417.2|NM_145665.1	NP_115793.1|NP_663698.1			SPANX family, member D											breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	9	Acute lymphoblastic leukemia(192;7.65e-05)					TTCACCAGTTCCTCTGGAGAT	0.458000													5	118					0	0	0.184627	0	0
CLCN6	1185	broad.mit.edu	37	1	11884570	11884570	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:11884570T>C	ENST00000346436.6	+	8	660	c.608T>C	c.(607-609)aTg>aCg	p.M203T	CLCN6_ENST00000312413.6_Missense_Mutation_p.M203T|CLCN6_ENST00000376487.3_Missense_Mutation_p.M181T|CLCN6_ENST00000376492.3_3'UTR|CLCN6_ENST00000376496.3_Missense_Mutation_p.M203T	NM_001286.3	NP_001277.1	P51797	CLCN6_HUMAN	chloride channel, voltage-sensitive 6	203					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(4)	36	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGGCCCCATGATCCACAGT	0.597000													14	16					0	0	0.557998	0	0
BAGE2	85319	broad.mit.edu	37	21	11039227	11039227	+	RNA	SNP	G	G	A	rs147532624	by1000genomes	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr21:11039227G>A	ENST00000470054.1	-	0	976									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATTCTTCTTTGGATACCACTG	0.413000													7	98					0	0	0.248553	0	0
ADD1	118	broad.mit.edu	37	4	2927835	2927835	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr4:2927835G>A	ENST00000355842.3	+	16	2813	c.1950G>A	c.(1948-1950)gaG>gaA	p.E650E	ADD1_ENST00000446856.1_Silent_p.E619E|ADD1_ENST00000264758.7_Silent_p.E650E|ADD1_ENST00000398125.1_Silent_p.E650E|ADD1_ENST00000398129.1_Silent_p.E619E|ADD1_ENST00000503455.2_Silent_p.E650E|ADD1_ENST00000398123.2_Silent_p.E650E|ADD1_ENST00000513328.2_Silent_p.E619E			P35611	ADDA_HUMAN	adducin 1 (alpha)	619					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCAAGCTGGAGGAAGGTGAGC	0.632000													26	5					0	0	0.760397	0	0
NOP58	51602	broad.mit.edu	37	2	203160481	203160481	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:203160481C>T	ENST00000264279.5	+	10	1218	c.992C>T	c.(991-993)tCt>tTt	p.S331F		NM_015934.3	NP_057018.1	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein	331	Nop.				cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(4)|prostate(2)	16						GCCCTCAAATCTAGACGGGAT	0.428000													36	30					0	0	0.812448	0	0
ZNF208	7757	broad.mit.edu	37	19	22156453	22156453	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:22156453G>A	ENST00000397126.4	-	4	1531	c.1383C>T	c.(1381-1383)ggC>ggT	p.G461G	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATACTAAAGCCTTTGCCAC	0.383000													3	39					0	0	0.115264	0	0
SMOC2	64094	broad.mit.edu	37	6	168927078	168927078	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:168927078G>A	ENST00000354536.5	+	3	529	c.309G>A	c.(307-309)aaG>aaA	p.K103K	SMOC2_ENST00000356284.2_Silent_p.K103K	NM_022138.2	NP_071421.1	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	103	Thyroglobulin type-1 1.				signal transduction	basement membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	32		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		AAGCCCGGAAGGAGTTTCAGC	0.542000													20	36					0	0	0.693898	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368801	86368801	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr13:86368801G>A	ENST00000400286.2	-	2	2441	c.1843C>T	c.(1843-1845)Ctg>Ttg	p.L615L		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	615						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		AACATAATCAGAAGTCCCAAT	0.413000													44	23					0	0	0.870114	0	0
SYNE3	161176	broad.mit.edu	37	14	95932475	95932475	+	Silent	SNP	G	G	A	rs147089377		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:95932475G>A	ENST00000334258.5	-	3	434	c.420C>T	c.(418-420)atC>atT	p.I140I	SYNE3_ENST00000553340.1_Silent_p.I140I|SYNE3_ENST00000557275.1_Silent_p.I140I	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						GCTGGAGCTCGATGTGGGGCT	0.632000													36	20					0	0	0.827153	0	0
TMEM38B	55151	broad.mit.edu	37	9	108467982	108467982	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr9:108467982C>T	ENST00000374688.1	+	2	765	c.55C>T	c.(55-57)Cca>Tca	p.P19S	TMEM38B_ENST00000374692.3_Missense_Mutation_p.P73S			Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	73						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	13						TGCAGAGCCTCCATTGAAGTT	0.418000													45	19					0	0	0.870114	0	0
HMGB4	127540	broad.mit.edu	37	1	34330332	34330332	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:34330332G>A	ENST00000522796.1	+	4	2445	c.540G>A	c.(538-540)ggG>ggA	p.G180G	CSMD2_ENST00000373381.4_Intron|HMGB4_ENST00000425537.1_3'UTR|HMGB4_ENST00000519684.1_Silent_p.G180G			B2R4X7	B2R4X7_HUMAN	high mobility group box 4	180						nucleus	DNA binding			NS(1)|breast(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GGTGCAGAGGGAAAAGAGTCA	0.453000													13	20					0	0	0.539581	0	0
CADPS	8618	broad.mit.edu	37	3	62423879	62423879	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:62423879C>T	ENST00000383710.4	-	28	4026	c.3677G>A	c.(3676-3678)gGg>gAg	p.G1226E	CADPS_ENST00000283269.9_Missense_Mutation_p.G1187E|CADPS_ENST00000357948.3_Missense_Mutation_p.G1147E	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	1226	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CACGTCCATCCCGGGTTTCTG	0.458000													15	25					0	0	0.479597	0	0
ZNF148	7707	broad.mit.edu	37	3	124951262	124951262	+	Missense_Mutation	SNP	G	G	A	rs137930153		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr3:124951262G>A	ENST00000360647.4	-	9	2793	c.2308C>T	c.(2308-2310)Ccc>Tcc	p.P770S	SLC12A8_ENST00000423114.2_Intron|ZNF148_ENST00000484491.1_Missense_Mutation_p.P770S|ZNF148_ENST00000497929.1_5'UTR|ZNF148_ENST00000492394.1_Missense_Mutation_p.P770S|ZNF148_ENST00000468369.1_Missense_Mutation_p.P120S|ZNF148_ENST00000544464.1_Missense_Mutation_p.P107S|ZNF148_ENST00000485866.1_Missense_Mutation_p.P770S	NM_021964.2	NP_068799.2	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	770					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding	p.P770S(1)		breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)	28						TTCACCAAGGGAAATTCTGAA	0.408000													18	34					0	0	0.608945	0	0
OR1E1	8387	broad.mit.edu	37	17	3301698	3301698	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:3301698C>T	ENST00000322608.2	-	1	6	c.7G>A	c.(7-9)Gga>Aga	p.G3R		NM_003553.2	NP_003544.2	P30953	OR1E1_HUMAN	olfactory receptor, family 1, subfamily E, member 1	3					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(2)|lung(5)	10						TGATTTTGTCCCATCATGCTC	0.433000													27	36					0	0	0.840704	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G|EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													4	109					0	0	0.217242	0	0
HTRA4	203100	broad.mit.edu	37	8	38831791	38831791	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:38831791A>C	ENST00000302495.4	+	1	109	c.9A>C	c.(7-9)agA>agC	p.R3S		NM_153692.3	NP_710159.1	P83105	HTRA4_HUMAN	HtrA serine peptidase 4	3					proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	11		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			GGATGATTAGACCTCAGCTGC	0.617000													13	29					0	0	0.500413	0	0
MAP2K1	5604	broad.mit.edu	37	15	66727441	66727441	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:66727441T>A	ENST00000307102.5	+	2	688	c.157T>A	c.(157-159)Ttt>Att	p.F53I		NM_002755.3	NP_002746.1	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	53			F -> S (in CFC syndrome).		activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.F53L(2)|p.F53S(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(8)|urinary_tract(1)	20						CCTTGAGGCCTTTCTTACCCA	0.547000													40	94					0	0	0.847076	0	0
CLSTN3	9746	broad.mit.edu	37	12	7289520	7289520	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:7289520C>T	ENST00000537408.1	+	6	1598	c.1060C>T	c.(1060-1062)Ctg>Ttg	p.L354L	CLSTN3_ENST00000266546.6_Silent_p.L342L			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	342					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						GGACAGCAGCCTGATCTACTG	0.642000													49	57					0	0	0.870114	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18809753	18809753	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr1:18809753C>A	ENST00000400664.1	+	1	2330	c.2278C>A	c.(2278-2280)Ctc>Atc	p.L760I		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	760						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGGGCACCCTCCTGCCCAC	0.657000													19	56					2.27525e-19	2.30519e-19	0.667858	1	0
AMHR2	269	broad.mit.edu	37	12	53823694	53823694	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:53823694G>A	ENST00000257863.4	+	9	1300	c.1220G>A	c.(1219-1221)cGa>cAa	p.R407Q	AMHR2_ENST00000550311.1_Missense_Mutation_p.R407Q|AMHR2_ENST00000379791.3_Intron	NM_001164690.1|NM_020547.2	NP_001158162.1|NP_065434.1	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II	407	Protein kinase.				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|skin(2)	34					Adenosine triphosphate(DB00171)	GCCCTCCGACGAGCTGATATT	0.582000													25	31					0	0	0.681144	0	0
LAMB1	3912	broad.mit.edu	37	7	107601669	107601669	+	Silent	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:107601669G>A	ENST00000393561.1	-	15	2347	c.2163C>T	c.(2161-2163)ccC>ccT	p.P721P	LAMB1_ENST00000393560.1_Silent_p.P697P|LAMB1_ENST00000222399.6_Silent_p.P697P			P07942	LAMB1_HUMAN	laminin, beta 1	697	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCAGCGTGTAGGGGCTCTCCA	0.557000													45	59					0	0	0.870114	0	0
DNAH7	56171	broad.mit.edu	37	2	196753694	196753694	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:196753694C>T	ENST00000312428.6	-	32	5158	c.5058G>A	c.(5056-5058)agG>agA	p.R1686R		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1686	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TTAACCATTTCCTATCTGGAG	0.348000													25	92					0	0	0.796494	0	0
CNTN1	1272	broad.mit.edu	37	12	41421717	41421717	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:41421717C>T	ENST00000551295.2	+	22	2886	c.2769C>T	c.(2767-2769)atC>atT	p.I923I	CNTN1_ENST00000550305.1_3'UTR|CNTN1_ENST00000347616.1_Silent_p.I923I|CNTN1_ENST00000348761.2_Silent_p.I912I	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	923	Fibronectin type-III 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GCTATATAATCACCTGGGATC	0.388000													20	69					0	0	0.706142	0	0
THSD4	79875	broad.mit.edu	37	15	71447238	71447238	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:71447238C>T	ENST00000355327.3	+	3	200	c.66C>T	c.(64-66)ttC>ttT	p.F22F	THSD4_ENST00000261862.6_Silent_p.F22F|RP11-673C5.2_ENST00000561571.1_RNA			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	22						proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						GATTCCAGTTCGTCTGCCCAC	0.552000													49	54					0	0	0.870114	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885224	24885224	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:24885224C>T	ENST00000382554.3	+	9	4587	c.4269C>T	c.(4267-4269)tcC>tcT	p.S1423S		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1423					DNA integration	integral to membrane	DNA binding	p.S1423S(1)		breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						GCCTCTCATCCCTTCCGTTTA	0.617000													35	18					0	0	0.847076	0	0
MUC16	94025	broad.mit.edu	37	19	9064403	9064403	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:9064403C>T	ENST00000397910.4	-	3	23246	c.23043G>A	c.(23041-23043)gtG>gtA	p.V7681V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7683	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGTTTCTTTCACAAAGGGAG	0.547000													8	35					0	0	0.335167	0	0
BTBD2	55643	broad.mit.edu	37	19	1986899	1986899	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr19:1986899A>C	ENST00000255608.4	-	8	1362	c.1346T>G	c.(1345-1347)tTc>tGc	p.F449C		NM_017797.3	NP_060267.2	Q9BX70	BTBD2_HUMAN	BTB (POZ) domain containing 2	449						cytoplasmic mRNA processing body	protein binding			endometrium(5)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|stomach(1)	12		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CATGACGCGGAAGGTGCTGGC	0.642000													5	48					0	0	0.184627	0	0
ARSK	153642	broad.mit.edu	37	5	94927309	94927309	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:94927309A>G	ENST00000380009.4	+	6	1281	c.1076A>G	c.(1075-1077)gAt>gGt	p.D359G		NM_198150.2	NP_937793.1	Q6UWY0	ARSK_HUMAN	arylsulfatase family, member K	359						extracellular region	arylsulfatase activity|metal ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(1)	16		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		TCTCTTGTGGATATTTACCCT	0.393000													59	18					0	0	0.870114	0	0
OR11H12	440153	broad.mit.edu	37	14	19378555	19378555	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr14:19378555G>A	ENST00000550708.1	+	1	1034	c.962G>A	c.(961-963)gGa>gAa	p.G321E		NM_001013354.1|NM_001197287.1	NP_001013372.1|NP_001184216.1	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H, member 12	321					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AAAGTTCTGGGAAGTTCCAAC	0.363000													59	30					0	0	0.870114	0	0
FLNC	2318	broad.mit.edu	37	7	128480673	128480673	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:128480673G>A	ENST00000325888.8	+	10	1882	c.1621G>A	c.(1621-1623)Gtg>Atg	p.V541M	FLNC_ENST00000346177.6_Missense_Mutation_p.V541M	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	541					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CTACCCGGTGGTGCCTGGGAA	0.632000													127	180					0	0	0.870114	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47221207	47221207	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr6:47221207C>T	ENST00000296861.2	-	4	1687	c.1294G>A	c.(1294-1296)Gat>Aat	p.D432N		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	432	Death.				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			TGATAGATATCTTTCCACTGG	0.488000													8	12					0	0	0.307466	0	0
OR10G4	390264	broad.mit.edu	37	11	123886941	123886941	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:123886941C>T	ENST00000320891.4	+	1	660	c.660C>T	c.(658-660)atC>atT	p.I220I		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I220I(2)		NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		ATGTGTCCATCGTCTGTTCCA	0.542000													48	14					0	0	0.870114	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99448879	99448879	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:99448879C>T	ENST00000397899.2	-	5	803	c.472G>A	c.(472-474)Gac>Aac	p.D158N	KIAA1211L_ENST00000462314.1_5'UTR	NM_207362.2	NP_997245.2			KIAA1211-like																		GGCAGCCCGTCGTCCTCAGAG	0.587000													17	37					0	0	0.608945	0	0
VWA3A	146177	broad.mit.edu	37	16	22149750	22149750	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:22149750G>A	ENST00000389398.5	+	22	2305	c.2209G>A	c.(2209-2211)Gaa>Aaa	p.E737K	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	737						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		CCTCCCGAAAGAAAAACCAAA	0.567000													4	3					0	0	0.217242	0	0
SEPT7P2	641977	broad.mit.edu	37	7	45791226	45791226	+	RNA	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:45791226C>T	ENST00000429741.1	-	0	634																											TTTGTAAACTCAATATCCAAT	0.343000													3	5					0	0	0.150653	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110493695	110493695	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:110493695C>T	ENST00000378402.5	+	56	9465	c.9361C>T	c.(9361-9363)Cct>Tct	p.P3121S		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3121	G8 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGAAGATAACCCTTTTAAAGG	0.378000										HNSCC(38;0.096)			3	7					0	0	0.217242	0	0
POU5F2	134187	broad.mit.edu	37	5	93076865	93076865	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr5:93076865C>T	ENST00000510627.4	-	1	478	c.405G>A	c.(403-405)caG>caA	p.Q135Q	FAM172A_ENST00000395965.3_Intron|FAM172A_ENST00000505869.1_Intron|FAM172A_ENST00000509739.1_Intron|FAM172A_ENST00000509163.1_Intron	NM_153216.1	NP_694948.1	Q8N7G0	PO5F2_HUMAN	POU domain class 5, transcription factor 2	135	POU-specific.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity						all_cancers(142;3.87e-05)|all_epithelial(76;4.59e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0415)|all cancers(79;2.03e-19)		TCAACCTCTTCTGCCTCAACT	0.592000													27	18					0	0	0.760397	0	0
DNAH17	8632	broad.mit.edu	37	17	76503747	76503747	+	Silent	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr17:76503747C>T	ENST00000389840.5	-	28	4489	c.4365G>A	c.(4363-4365)ctG>ctA	p.L1455L	DNAH17_ENST00000585328.1_Silent_p.L1456L					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGGACATCATCAGGTTCTGCA	0.607000													6	27					0	0	0.335167	0	0
TPTE	7179	broad.mit.edu	37	21	10916373	10916373	+	Missense_Mutation	SNP	G	G	A	rs138794341	byFrequency	TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr21:10916373G>A	ENST00000298232.7	-	19	1586	c.1219C>T	c.(1219-1221)Cct>Tct	p.P407S	TPTE_ENST00000361285.4_Missense_Mutation_p.P425S|TPTE_ENST00000415664.2_Intron|TPTE_ENST00000342420.5_Missense_Mutation_p.P387S	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	425					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CACTTACGAGGAATCGAATAA	0.388000													15	49					0	0	0.557998	0	0
LRP1B	53353	broad.mit.edu	37	2	140995831	140995831	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:140995831C>T	ENST00000389484.3	-	89	14421	c.13450G>A	c.(13450-13452)Gga>Aga	p.G4484R		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4484					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTATTCCTCCATTGATAATA	0.303000										TSP Lung(27;0.18)			6	18					0	0	0.217242	0	0
METTL8	79828	broad.mit.edu	37	2	172195817	172195846	+	In_Frame_Del	DEL	ACCAGAACTTTTCTCATAATGATTTTTTTC	ACCAGAACTTTTCTCATAATGATTTTTTTC	-			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr2:172195817_172195846delACCAGAACTTTTCTCATAATGATTTTTTTC	ENST00000375258.3	-	4	669_698	c.454_483delGAAAAAAATCATTATGAGAAAAGTTCTGGT	c.(454-483)del	p.EKNHYEKSSG152del				B3KW44	B3KW44_HUMAN	methyltransferase like 8	152							methyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	11						CTTCTGAAGAACCAGAACTTTTCTCATAATGATTTTTTTCATCAGGCACA	0.383													16	62	---	---	---	---					
PKD1L1	168507	broad.mit.edu	37	7	47832245	47832245	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr7:47832245delA	ENST00000289672.2	-	56	8556	c.8506delT	c.(8506-8508)ctfs	p.S2837fs		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2837					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TGGTAACTAGAAATGTCCACT	0.393													94	128	---	---	---	---					
ADAM2	2515	broad.mit.edu	37	8	39604019	39604020	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:39604019_39604020insT	ENST00000265708.4	-	19	2248_2249	c.2145_2146insA	c.(2143-2148)aaggagfs	p.E716fs	ADAM2_ENST00000521880.1_Frame_Shift_Ins_p.E653fs|ADAM2_ENST00000379853.2_Frame_Shift_Ins_p.E560fs|ADAM2_ENST00000347580.4_Frame_Shift_Ins_p.E697fs	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	716					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TCAGTTCTCCATTTTTTCCTTT	0.292													40	59	---	---	---	---					
CYP7B1	9420	broad.mit.edu	37	8	65509352	65509352	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr8:65509352delA	ENST00000310193.3	-	6	1541	c.1368delT	c.(1366-1368)ctfs	p.L456fs	CYP7B1_ENST00000523954.1_Intron	NM_004820.3	NP_004811.1	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B, polypeptide 1	456					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				TTATTTCCATAAGTGCAAAAA	0.353													21	25	---	---	---	---					
LOC283299	283299	broad.mit.edu	37	11	7802564	7802564	+	RNA	DEL	C	C	-	rs112070392		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr11:7802564delC	ENST00000527565.1	-	0	542																											cagcacagcacaactgctcta	0.537													2	4	---	---	---	---					
PTPRB	5787	broad.mit.edu	37	12	70953109	70953109	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:70953109delA	ENST00000551525.1	-	18	4749	c.4725delT	c.(4723-4725)ttfs	p.F1575fs	PTPRB_ENST00000334414.6_Intron|PTPRB_ENST00000550358.1_Intron|PTPRB_ENST00000550857.1_Intron|PTPRB_ENST00000538708.1_Intron|PTPRB_ENST00000451516.2_Intron|PTPRB_ENST00000261266.5_Intron			P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TAAGAGTAGCAAAACATGTCA	0.373													46	91	---	---	---	---					
CEP290	80184	broad.mit.edu	37	12	88449444	88449444	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr12:88449444delT	ENST00000552810.1	-	50	7212	c.6869delA	c.(6868-6870)atfs	p.N2290fs	CEP290_ENST00000547691.2_Frame_Shift_Del_p.N1350fs|CEP290_ENST00000309041.7_Frame_Shift_Del_p.N2292fs|CEP290_ENST00000397838.3_Frame_Shift_Del_p.N1350fs	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	2290					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						AATGCTTTGATTTTTTTTGGC	0.299													3	5	---	---	---	---					
RP11-519G16.3	0	broad.mit.edu	37	15	45755164	45755166	+	RNA	DEL	CAC	CAC	-			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:45755164_45755166delCAC	ENST00000560077.1	+	0	41				RP11-519G16.3_ENST00000558536.1_RNA|RP11-519G16.3_ENST00000560647.1_RNA																							ccatcaccatcaccaccaccacc	0.596													2	4	---	---	---	---					
ZNF280D	54816	broad.mit.edu	37	15	56993114	56993114	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr15:56993114delG	ENST00000558320.1	-	6	512	c.398delC	c.(397-399)atfs	p.T133fs	ZNF280D_ENST00000396245.1_Intron|ZNF280D_ENST00000559237.1_Intron|ZNF280D_ENST00000267807.7_Intron|ZNF280D_ENST00000559000.1_Intron	NM_001002844.1	NP_001002844.1	Q6N043	Z280D_HUMAN	zinc finger protein 280D	133					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(4)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	30				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		TGGCCGTATAGTTTTAGAAAC	0.393													10	43	---	---	---	---					
LOC100134368	100134368	broad.mit.edu	37	16	437288	437289	+	RNA	DEL	AA	AA	-	rs137908843		TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:437288_437289delAA	ENST00000412293.1	+	0	521					NR_024453.2																						ttgtcaccataaaaaaaaaaat	0.426													2	4	---	---	---	---					
IL27	246778	broad.mit.edu	37	16	28511176	28511178	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr16:28511176_28511178delCTC	ENST00000356897.1	-	5	548_550	c.526_528delGAG	c.(526-528)del	p.E176del		NM_145659.3	NP_663634.2	Q8NEV9	IL27A_HUMAN	interleukin 27	176	Glu-rich.				inflammatory response|innate immune response|positive regulation of interferon-gamma biosynthetic process|regulation of defense response to virus|regulation of T cell proliferation|regulation of T-helper 1 cell differentiation	extracellular space	cytokine activity|interleukin-27 receptor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	10						GCCCCTtcctctcctcctcctcc	0.685													2	4	---	---	---	---					
ZBTB7C	201501	broad.mit.edu	37	18	45555705	45555705	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chr18:45555705delC	ENST00000588982.1	-	4	2287	c.1786delG	c.(1786-1788)ccfs	p.A597fs	ZBTB7C_ENST00000535628.2_Frame_Shift_Del_p.A597fs|ZBTB7C_ENST00000590800.1_Frame_Shift_Del_p.A597fs|ZBTB7C_ENST00000332053.2_Frame_Shift_Del_p.A597fs|ZBTB7C_ENST00000586438.1_Frame_Shift_Del_p.A597fs			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	597						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						AGGCCGGCGGCCCAAGGGTCG	0.736													2	4	---	---	---	---					
VSIG1	340547	broad.mit.edu	37	X	107315930	107315930	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A3MV-06A-11D-A21A-08	TCGA-D3-A3MV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	60b65a17-69a7-4dd5-937c-8e047bb1cf93	0e31ab41-4ba6-48e1-9f2f-ee3f13ebcb19	g.chrX:107315930delA	ENST00000415430.3	+	5	705	c.544delA	c.(544-546)gcfs	p.S182fs	VSIG1_ENST00000485533.1_3'UTR|VSIG1_ENST00000217957.5_Frame_Shift_Del_p.S146fs	NM_001170553.1	NP_001164024.1	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	146	Ig-like C2-type 2.					integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17						GCCCCTTTGTAGCGTTCAAGG	0.443													39	56	---	---	---	---