Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NDC1	55706	broad.mit.edu	37	1	54238032	54238032	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:54238032C>T	ENST00000371429.3	-	17	2529	c.1931G>A	c.(1930-1932)cGa>cAa	p.R644Q	NDC1_ENST00000540001.1_3'UTR|NDC1_ENST00000537333.1_Missense_Mutation_p.R309Q|NDC1_ENST00000234725.8_Missense_Mutation_p.R529Q	NM_001168551.1|NM_018087.4	NP_001162023.1|NP_060557.3			NDC1 transmembrane nucleoporin																		AGTAGTTATTCGATAGATGGC	0.393000													36	84					0	0	0.004878	0	0
TCF23	150921	broad.mit.edu	37	2	27372192	27372192	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:27372192G>A	ENST00000296096.5	+	1	321	c.191G>A	c.(190-192)gGg>gAg	p.G64E	TCF23_ENST00000407815.3_3'UTR	NM_175769.2	NP_786951.1	Q7RTU1	TCF23_HUMAN	transcription factor 23	64					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent	nucleus				large_intestine(2)|lung(11)|prostate(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCCTCGAGGGACCAGGGCT	0.632000													3	7					0	0	0.004672	0	0
DEFB121	245934	broad.mit.edu	37	20	29992835	29992835	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr20:29992835C>T	ENST00000376314.2	-	2	225	c.112G>A	c.(112-114)Gaa>Aaa	p.E38K	DEFB121_ENST00000376312.3_5'UTR	NM_001011878.2	NP_001011878.1	Q5J5C9	DB121_HUMAN	defensin, beta 121	38					defense response to bacterium	extracellular region				large_intestine(1)|lung(1)	2	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TAGTATACTTCACTTTCTTTA	0.378000													15	29					0	0	0.004007	0	0
SLC35C2	51006	broad.mit.edu	37	20	44980726	44980726	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr20:44980726G>A	ENST00000372227.1	-	8	1341	c.801C>T	c.(799-801)acC>acT	p.T267T	SLC35C2_ENST00000243896.2_Silent_p.T267T|SLC35C2_ENST00000372230.5_Silent_p.T267T|SLC35C2_ENST00000493599.1_5'UTR|SLC35C2_ENST00000543605.1_Silent_p.T296T|SLC35C2_ENST00000372229.1_Silent_p.T134T|SLC35C2_ENST00000317734.8_Silent_p.T246T			Q9NQQ7	S35C2_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C2	267					transport	integral to membrane				cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	16		Myeloproliferative disorder(115;0.0122)				TGAGGCTGGAGGTTCTGGAGA	0.582000													11	48					0	0	0.008291	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150532255	150532255	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:150532255G>A	ENST00000271643.4	+	18	3198	c.2962G>A	c.(2962-2964)Ggg>Agg	p.G988R	ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.G1011R|ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.G988R	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	988	TSP type-1 6.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTCCTGCCAAGGGGGAACGCA	0.637000											OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	185					0	0	0.001786	0	0
CCDC61	729440	broad.mit.edu	37	19	46511402	46511402	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:46511402C>T	ENST00000263284.2	+	6	565	c.565C>T	c.(565-567)Cac>Tac	p.H189Y	CCDC61_ENST00000594087.1_Missense_Mutation_p.H132Y|CCDC61_ENST00000595358.1_Missense_Mutation_p.H132Y|CCDC61_ENST00000536603.1_Missense_Mutation_p.H132Y					coiled-coil domain containing 61											endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00221)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.164)		CCTCAGGATTCACTACCCGCT	0.587000													8	18					0	0	0.003080	0	0
NOTCH4	4855	broad.mit.edu	37	6	32187406	32187406	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr6:32187406C>T	ENST00000375023.3	-	8	1611	c.1473G>A	c.(1471-1473)ctG>ctA	p.L491L		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	491	EGF-like 12; calcium-binding (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						CAAGTAGGTCCAGACAGGTGC	0.592000													96	335					0	0	0.003610	0	0
NLRC4	58484	broad.mit.edu	37	2	32461352	32461352	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:32461352G>A	ENST00000404025.2	-	8	3066	c.2578C>T	c.(2578-2580)Ctg>Ttg	p.L860L	NLRC4_ENST00000360906.5_Silent_p.L860L|NLRC4_ENST00000342905.6_Silent_p.L195L|NLRC4_ENST00000402280.1_Silent_p.L860L			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	860					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TCTTTTTCCAGGTAATTTTCT	0.318000													16	47					0	0	0.004990	0	0
ZNF365	22891	broad.mit.edu	37	10	64159453	64159453	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr10:64159453C>T	ENST00000395254.3	+	5	1409	c.1129C>T	c.(1129-1131)Cca>Tca	p.P377S	ZNF365_ENST00000395255.3_Intron|ZNF365_ENST00000410046.3_Intron|ZNF365_ENST00000466727.1_3'UTR	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	0										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					CTGCAGACCTCCAAAGAAAGG	0.517000													38	46					0	0	0.004878	0	0
PDZRN4	29951	broad.mit.edu	37	12	41900423	41900423	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:41900423G>A	ENST00000298919.7	+	4	617	c.229G>A	c.(229-231)Gac>Aac	p.D77N	PDZRN4_ENST00000402685.2_Missense_Mutation_p.D337N|PDZRN4_ENST00000539469.2_Missense_Mutation_p.D79N			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	337							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				CACTCAGACGGACATCACCTT	0.527000													25	38					0	0	0.003954	0	0
ADAM28	10863	broad.mit.edu	37	8	24197052	24197052	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:24197052G>A	ENST00000265769.4	+	15	1751	c.1641G>A	c.(1639-1641)gtG>gtA	p.V547V	RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000397649.3_Silent_p.V294V|RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	547	Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		GTCGCAGAGTGGATGACACAC	0.488000													5	14					0	0	0.000602	0	0
HGF	3082	broad.mit.edu	37	7	81388078	81388078	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:81388078G>A	ENST00000222390.5	-	3	523	c.297C>T	c.(295-297)ttC>ttT	p.F99F	HGF_ENST00000444829.2_Silent_p.F99F|HGF_ENST00000453411.1_Silent_p.F99F|HGF_ENST00000423064.2_Silent_p.F99F|HGF_ENST00000354224.6_Silent_p.F99F|HGF_ENST00000453018.1_5'UTR|HGF_ENST00000457544.2_Silent_p.F99F	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	99	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						TATTGAAGGGGAACCAGAGGC	0.318000													58	79					0	0	0.003610	0	0
COL4A3	1285	broad.mit.edu	37	2	228137771	228137771	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:228137771G>A	ENST00000396578.3	+	26	2027	c.1865G>A	c.(1864-1866)gGa>gAa	p.G622E	AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000439598.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	622	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity	p.G622E(2)		NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGACCCCAAGGAGAACCTGGT	0.622000													27	53					0	0	0.004656	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963644	88963644	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:88963644G>A	ENST00000333190.4	+	4	1957	c.1348G>A	c.(1348-1350)Gat>Aat	p.D450N		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	450						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TCAAAGCAAGGATGGCCACAC	0.398000										HNSCC(36;0.09)			24	89					0	0	0.004656	0	0
SFRP4	6424	broad.mit.edu	37	7	37954014	37954014	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:37954014C>T	ENST00000436072.2	-	2	864	c.487G>A	c.(487-489)Gaa>Aaa	p.E163K	EPDR1_ENST00000476620.1_Intron	NM_003014.3	NP_003005.2	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related protein 4	163					brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						AGAGGCCTTTCCTGTACCATC	0.483000													41	46					0	0	0.003610	0	0
SOX11	6664	broad.mit.edu	37	2	5833922	5833922	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:5833922G>A	ENST00000322002.3	+	1	1124	c.1069G>A	c.(1069-1071)Gac>Aac	p.D357N		NM_003108.3	NP_003099.1	P35716	SOX11_HUMAN	SRY (sex determining region Y)-box 11	357					cardiac ventricle formation|closure of optic fissure|cornea development in camera-type eye|embryonic digestive tract morphogenesis|embryonic skeletal system morphogenesis|eyelid development in camera-type eye|glial cell proliferation|hard palate development|lens morphogenesis in camera-type eye|limb bud formation|lung morphogenesis|negative regulation of cell death|negative regulation of glial cell proliferation|negative regulation of lymphocyte proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|neural crest cell development|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|outflow tract morphogenesis|positive regulation of BMP signaling pathway|positive regulation of hippo signaling cascade|positive regulation of hormone secretion|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of ossification|positive regulation of osteoblast differentiation|positive regulation of stem cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in G1/S transition checkpoint|soft palate development|somite development|spinal cord development|sympathetic nervous system development|ventricular septum morphogenesis	cytoplasm|nucleolus	enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|translation factor activity, nucleic acid binding			central_nervous_system(5)|cervix(1)|endometrium(1)|liver(1)|lung(4)|stomach(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			OV - Ovarian serous cystadenocarcinoma(76;0.132)		cagcggcGAGGACGCCGACGA	0.726000													4	4					0	0	0.000248	0	0
ABCA10	10349	broad.mit.edu	37	17	67148207	67148207	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:67148207G>A	ENST00000269081.4	-	37	5283	c.4374C>T	c.(4372-4374)ttC>ttT	p.F1458F	ABCA10_ENST00000519732.1_5'UTR|ABCA10_ENST00000416101.2_3'UTR	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	1458					transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					CAGCCTGTGGGAAAAGCTTCA	0.378000													25	81					0	0	0.005443	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19363171	19363171	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:19363171C>T	ENST00000454498.2	-	4	1188	c.175G>A	c.(175-177)Gcc>Acc	p.A59T	CSGALNACT1_ENST00000544602.1_Missense_Mutation_p.A59T|CSGALNACT1_ENST00000522854.1_Missense_Mutation_p.A59T|CSGALNACT1_ENST00000311540.4_Missense_Mutation_p.A59T|CSGALNACT1_ENST00000332246.6_Missense_Mutation_p.A59T	NM_001130518.1	NP_001123990.1	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 1	59					anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				Colorectal(111;0.182)		TGAAGGACGGCCTGGTACCCC	0.622000													6	39					0	0	0.003080	0	0
ZIC4	84107	broad.mit.edu	37	3	147108847	147108847	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:147108847G>A	ENST00000383075.3	-	4	1387	c.875C>T	c.(874-876)cCg>cTg	p.P292L	ZIC4_ENST00000484399.1_Missense_Mutation_p.P292L|ZIC4_ENST00000473123.1_Missense_Mutation_p.P292L|ZIC4_ENST00000472749.2_5'UTR|ZIC4_ENST00000525172.2_Missense_Mutation_p.P342L|ZIC4_ENST00000425731.3_Missense_Mutation_p.P330L|ZIC4_ENST00000491672.1_Missense_Mutation_p.P86L	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	292						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						GCTGGGCGGCGGCGAGCGCCC	0.672000													20	39					0	0	0.002299	0	0
GTF3C4	9329	broad.mit.edu	37	9	135559040	135559040	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr9:135559040C>T	ENST00000372146.4	+	3	2839	c.2275C>T	c.(2275-2277)Cgc>Tgc	p.R759C		NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	759					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		ATTCACAGATCGCAAACAGGC	0.408000													21	35					0	0	0.001882	0	0
ALOXE3	59344	broad.mit.edu	37	17	8000072	8000072	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:8000072C>T	ENST00000380149.1	-	15	2507	c.2477G>A	c.(2476-2478)cGg>cAg	p.R826Q	ALOXE3_ENST00000448843.2_Missense_Mutation_p.R670Q|ALOXE3_ENST00000318227.3_Missense_Mutation_p.R802Q			Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3	670					leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	31						GGCGATGCTCCGCCTCGGGGC	0.632000													26	72					0	0	0.007291	0	0
NDUFV1	4723	broad.mit.edu	37	11	67379630	67379630	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:67379630G>A	ENST00000322776.6	+	9	1355	c.1202G>A	c.(1201-1203)aGg>aAg	p.R401K	NDUFV1_ENST00000415352.2_Missense_Mutation_p.R394K|NDUFV1_ENST00000529927.1_Missense_Mutation_p.R392K|NDUFV1_ENST00000532303.1_Missense_Mutation_p.R300K	NM_001166102.1|NM_007103.3	NP_001159574.1|NP_009034.2	P49821	NDUV1_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	401					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	16					NADH(DB00157)	CGTTTCGTGAGGGGGGATGCC	0.632000													33	90					0	0	0.005524	0	0
SPAG17	200162	broad.mit.edu	37	1	118539226	118539226	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:118539226G>A	ENST00000336338.5	-	33	4982	c.4917C>T	c.(4915-4917)gtC>gtT	p.V1639V		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1639						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTTACCTGGGGACATGTTCAC	0.299000													8	52					0	0	0.006214	0	0
UBE3D	90025	broad.mit.edu	37	6	83667048	83667048	+	Missense_Mutation	SNP	G	G	A	rs143403921	byFrequency	TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr6:83667048G>A	ENST00000369747.3	-	9	1254	c.1132C>T	c.(1132-1134)Cgt>Tgt	p.R378C		NM_198920.1	NP_944602.1	Q7Z6J8	UB2CB_HUMAN	ubiquitin protein ligase E3D	378	HECT-like.					cytoplasm	ligase activity										GAATTCACACGGCGAAGGGAT	0.463000													3	10					0	0	0.000602	0	0
SLX4	84464	broad.mit.edu	37	16	3644580	3644580	+	Silent	SNP	A	A	C			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr16:3644580A>C	ENST00000294008.3	-	10	2674	c.2034T>G	c.(2032-2034)gtT>gtG	p.V678V		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	678					DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CAAAGTCAGCAACCAGCAGCC	0.587000								Direct reversal of damage					10	35					0	0	0.008291	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720785	140720785	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:140720785C>T	ENST00000394576.2	+	1	2247	c.2247C>T	c.(2245-2247)ttC>ttT	p.F749F	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCGGGCTTTCCTGCAGACCT	0.627000													22	67					0	0	0.003954	0	0
CCL11	6356	broad.mit.edu	37	17	32614638	32614638	+	Missense_Mutation	SNP	G	G	A	rs56358892		TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:32614638G>A	ENST00000305869.3	+	3	364	c.223G>A	c.(223-225)Gac>Aac	p.D75N		NM_002986.2	NP_002977.1	P51671	CCL11_HUMAN	chemokine (C-C motif) ligand 11	75					cell adhesion|cellular calcium ion homeostasis|immune response|positive regulation of actin filament polymerization|positive regulation of cell migration|positive regulation of endothelial cell proliferation|positive regulation of Rac GTPase activity|protein phosphorylation|response to radiation|response to virus|signal transduction	extracellular space	chemokine activity			breast(1)|lung(1)|prostate(1)	3	Breast(3;0.00224)	Breast(31;0.151)|Ovarian(249;0.17)		BRCA - Breast invasive adenocarcinoma(366;0.155)		TATCTGTGCCGACCCCAAGAA	0.423000													15	27					0	0	0.008871	0	0
COL4A3	1285	broad.mit.edu	37	2	228128587	228128587	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:228128587G>A	ENST00000396578.3	+	21	1404	c.1242G>A	c.(1240-1242)atG>atA	p.M414I	AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000437673.1_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	414	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity	p.M414I(2)		NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		AGGATGCCATGGGGACTCCTG	0.602000													15	37					0	0	0.002450	0	0
ZNF302	55900	broad.mit.edu	37	19	35176128	35176128	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:35176128C>T	ENST00000505242.1	+	5	1680	c.1186C>T	c.(1186-1188)Ccg>Tcg	p.P396S	ZNF302_ENST00000457781.2_Missense_Mutation_p.P396S|ZNF302_ENST00000505365.2_3'UTR|ZNF302_ENST00000423823.2_Missense_Mutation_p.P396S|ZNF302_ENST00000446502.2_Missense_Mutation_p.P440S			Q9NR11	ZN302_HUMAN	zinc finger protein 302	475					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(2)|skin(1)	6	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGAAGAAAAACCGTTTGAAGT	0.338000													12	44					0	0	0.000978	0	0
FNIP1	96459	broad.mit.edu	37	5	131054747	131054747	+	Silent	SNP	A	A	G			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:131054747A>G	ENST00000307968.7	-	5	461	c.462T>C	c.(460-462)ccT>ccC	p.P154P	FNIP1_ENST00000514667.1_Intron|FNIP1_ENST00000510461.1_Silent_p.P154P|FNIP1_ENST00000307954.8_Silent_p.P109P|FNIP1_ENST00000511848.1_Silent_p.P154P	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TGAGCTGTGGAGGGGAACTAT	0.383000													28	76					0	0	0.008361	0	0
DSCAML1	57453	broad.mit.edu	37	11	117314695	117314695	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:117314695G>A	ENST00000321322.6	-	21	3950	c.3949C>T	c.(3949-3951)Cgc>Tgc	p.R1317C	DSCAML1_ENST00000527706.1_Missense_Mutation_p.R1047C	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1257	Ig-like C2-type 10.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TGCTGACCGCGGTTTAGGTGG	0.627000													12	22					0	0	0.001855	0	0
EEF1G	1937	broad.mit.edu	37	11	62327212	62327212	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:62327212G>A	ENST00000378019.3	-	10	1493	c.1403C>T	c.(1402-1404)tCc>tTc	p.S468F	EEF1G_ENST00000329251.4_Missense_Mutation_p.S418F|MIR3654_ENST00000496634.2_3'UTR			P26641	EF1G_HUMAN	eukaryotic translation elongation factor 1 gamma	418					response to virus	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CCCCTCCCAGGAAAAGTACTC	0.557000													14	17					0	0	0.001855	0	0
PITPNM3	83394	broad.mit.edu	37	17	6406856	6406856	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:6406856C>T	ENST00000262483.8	-	4	352	c.265G>A	c.(265-267)Gag>Aag	p.E89K	ACKR6_ENST00000421306.3_Missense_Mutation_p.E53K	NM_031220.3	NP_112497.2																					CGCTGCTTCTCCTGGAGGATG	0.557000													8	46					0	0	0.003080	0	0
LTBP1	4052	broad.mit.edu	37	2	33505184	33505184	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:33505184C>T	ENST00000404816.2	+	19	3424	c.3071C>T	c.(3070-3072)cCc>cTc	p.P1024L	LTBP1_ENST00000404525.1_Missense_Mutation_p.P645L|LTBP1_ENST00000407925.1_Missense_Mutation_p.P698L|LTBP1_ENST00000390003.4_Missense_Mutation_p.P699L|LTBP1_ENST00000354476.3_Missense_Mutation_p.P1025L|LTBP1_ENST00000418533.2_Missense_Mutation_p.P698L|LTBP1_ENST00000402934.1_Missense_Mutation_p.P645L			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1024	EGF-like 7; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CAGTGCGTTCCCTGCACAGAA	0.423000													18	47					0	0	0.006122	0	0
DCUN1D3	123879	broad.mit.edu	37	16	20873521	20873521	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr16:20873521A>C	ENST00000324344.3	-	2	625	c.340T>G	c.(340-342)Ttt>Gtt	p.F114V	DCUN1D3_ENST00000563934.1_Missense_Mutation_p.F114V|ERI2_ENST00000564349.1_Intron	NM_173475.2	NP_775746.1	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 3	114	DCUN1.				negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				NS(2)|breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)	14				GBM - Glioblastoma multiforme(48;0.249)		TCATTGCAAAAGCGCTCCATG	0.502000													28	78					0	0	0.005443	0	0
RNF111	54778	broad.mit.edu	37	15	59381920	59381920	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr15:59381920G>C	ENST00000348370.4	+	11	3038	c.2605G>C	c.(2605-2607)Gga>Cga	p.G869R	RNF111_ENST00000561186.1_Missense_Mutation_p.G878R|RNF111_ENST00000557998.1_Missense_Mutation_p.G869R|RNF111_ENST00000434298.1_Missense_Mutation_p.G878R|RNF111_ENST00000559209.1_Missense_Mutation_p.G878R	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	869					multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		AGGATTGGATGGAACATCATT	0.343000													73	193					0	0	0.003610	0	0
CCDC30	728621	broad.mit.edu	37	1	43119491	43119491	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:43119491T>C	ENST00000428554.2	+	23	3287	c.2144T>C	c.(2143-2145)tTt>tCt	p.F715S	CCDC30_ENST00000390640.4_Missense_Mutation_p.F504S|CCDC30_ENST00000340612.4_Missense_Mutation_p.F715S|CCDC30_ENST00000342022.4_Missense_Mutation_p.F715S|CCDC30_ENST00000507855.1_Missense_Mutation_p.F504S			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	715										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						TTTCTTAGTTTTTCAGGAAAA	0.383000													7	28					0	0	0.003080	0	0
DCHS2	54798	broad.mit.edu	37	4	155312345	155312345	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:155312345C>T	ENST00000357232.3	-	1	104	c.105G>A	c.(103-105)gtG>gtA	p.V35V	DCHS2_ENST00000339452.1_Intron	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	35					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AATTTATTTTCACATACACCT	0.328000													8	26					0	0	0.000978	0	0
MAD2L2	10459	broad.mit.edu	37	1	11736106	11736106	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:11736106G>A	ENST00000235310.3	-	8	1352	c.424C>T	c.(424-426)Cca>Tca	p.P142S	MAD2L2_ENST00000376667.3_Missense_Mutation_p.P142S|MAD2L2_ENST00000376692.4_Missense_Mutation_p.P142S|MAD2L2_ENST00000376669.5_Missense_Mutation_p.P155S|MAD2L2_ENST00000376672.1_Missense_Mutation_p.P155S			Q9UI95	MD2L2_HUMAN	MAD2 mitotic arrest deficient-like 2 (yeast)	142	HORMA.|Mediates interaction with REV1 and REV3L and homodimerization.				cell division|DNA damage response, signal transduction resulting in transcription|double-strand break repair|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of mitotic anaphase-promoting complex activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription, DNA-dependent|regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleoplasm|spindle|zeta DNA polymerase complex	JUN kinase binding			kidney(1)|large_intestine(1)|lung(2)|ovary(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GACACACCTGGGGGGTTGTGG	0.577000								DNA polymerases (catalytic subunits)					13	39					0	0	0.004007	0	0
GRID2	2895	broad.mit.edu	37	4	94436522	94436522	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:94436522C>T	ENST00000282020.4	+	13	2411	c.2153C>T	c.(2152-2154)tCg>tTg	p.S718L	GRID2_ENST00000510992.1_Missense_Mutation_p.S623L	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	718					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity	p.S718L(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AGCAATGGATCGGAGAACAAT	0.468000													14	51					0	0	0.006122	0	0
CNGB1	1258	broad.mit.edu	37	16	57984328	57984328	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr16:57984328G>A	ENST00000564448.1	-	13	1033	c.973C>T	c.(973-975)Cca>Tca	p.P325S	CNGB1_ENST00000251102.8_Missense_Mutation_p.P331S			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	331					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						TCATAAGCTGGAACCACCTCT	0.517000													30	60					0	0	0.004289	0	0
XIRP1	165904	broad.mit.edu	37	3	39226585	39226585	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:39226585T>C	ENST00000340369.3	-	2	4580	c.4352A>G	c.(4351-4353)gAa>gGa	p.E1451G	XIRP1_ENST00000396251.1_3'UTR|XIRP1_ENST00000421646.1_Missense_Mutation_p.E134G	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1451							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GTGGGAACCTTCCATGGGCTG	0.622000													37	120					0	0	0.007835	0	0
P2RY14	9934	broad.mit.edu	37	3	150931772	150931772	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:150931772G>A	ENST00000309170.3	-	3	645	c.333C>T	c.(331-333)ttC>ttT	p.F111F	P2RY14_ENST00000424796.2_Silent_p.F111F|MED12L_ENST00000474524.1_Intron|MED12L_ENST00000273432.4_Intron	NM_001081455.1|NM_014879.3	NP_001074924.1|NP_055694.3	Q15391	P2Y14_HUMAN	purinergic receptor P2Y, G-protein coupled, 14	111						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)	20			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGAGCCCAAAGAACACAATGC	0.463000													13	36					0	0	0.001855	0	0
AMZ1	155185	broad.mit.edu	37	7	2752501	2752501	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:2752501G>A	ENST00000312371.4	+	7	1854	c.1486G>A	c.(1486-1488)Gaa>Aaa	p.E496K	AMZ1_ENST00000407112.1_3'UTR|AMZ1_ENST00000489665.1_Intron	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	496							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		CTGGGATGGGGAAGAGAGTTA	0.617000													33	39					0	0	0.002445	0	0
PSG9	5678	broad.mit.edu	37	19	43763198	43763198	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:43763198C>T	ENST00000418820.2	-	3	618	c.520G>A	c.(520-522)Gag>Aag	p.E174K	PSG9_ENST00000593948.1_Intron|PSG9_ENST00000270077.3_Missense_Mutation_p.E267K|PSG9_ENST00000443718.3_Missense_Mutation_p.E174K|PSG9_ENST00000291752.5_Intron|PSG9_ENST00000596730.1_Intron|PSG9_ENST00000244293.7_Intron			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	174	Ig-like C2-type 1.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				GTGTAGTTCTCACTCTTAGGT	0.498000													85	185					0	0	0.003610	0	0
IQCF1	132141	broad.mit.edu	37	3	51928965	51928965	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:51928965A>T	ENST00000310914.5	-	4	621	c.559T>A	c.(559-561)Ttg>Atg	p.L187M		NM_152397.2	NP_689610.2	Q8N6M8	IQCF1_HUMAN	IQ motif containing F1	187										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GAGTCCAGCAAGATCTCCAGC	0.527000													39	69					0	0	0.004289	0	0
CCDC88C	440193	broad.mit.edu	37	14	91791208	91791208	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:91791208C>A	ENST00000389857.6	-	12	1343	c.1257G>T	c.(1255-1257)gaG>gaT	p.E419D		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	419					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TCTGTGCAATCTCAAGGACCA	0.547000													25	65					9.57634e-11	1.08775e-10	0.003330	1	0
MXRA5	25878	broad.mit.edu	37	X	3240718	3240718	+	Missense_Mutation	SNP	G	G	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chrX:3240718G>T	ENST00000217939.6	-	5	3162	c.3008C>A	c.(3007-3009)cCa>cAa	p.P1003Q		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1003						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGTGGGGGTTGGAGTAAGGTG	0.463000													39	38					4.32679e-17	4.92806e-17	0.006999	1	0
PLD5	200150	broad.mit.edu	37	1	242253348	242253348	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:242253348C>T	ENST00000442594.2	-	11	1652	c.1143G>A	c.(1141-1143)caG>caA	p.Q381Q	PLD5_ENST00000427495.1_Silent_p.Q411Q|PLD5_ENST00000536534.1_Silent_p.Q473Q	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	473						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TCACATCTGCCTGGTTGATAA	0.413000													28	134					0	0	0.004656	0	0
NETO1	81832	broad.mit.edu	37	18	70423306	70423306	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr18:70423306C>G	ENST00000327305.6	-	8	1602	c.945G>C	c.(943-945)caG>caC	p.Q315H	NETO1_ENST00000299430.2_Missense_Mutation_p.Q314H|NETO1_ENST00000583169.1_Missense_Mutation_p.Q315H	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	315	LDL-receptor class A.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		ACACACAGTTCTGGAGTCCAT	0.373000													16	54					0	0	0.002299	0	0
PCSK9	255738	broad.mit.edu	37	1	55518345	55518345	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:55518345G>A	ENST00000302118.5	+	5	970	c.680G>A	c.(679-681)gGc>gAc	p.G227D	PCSK9_ENST00000490692.1_3'UTR|PCSK9_ENST00000452118.2_3'UTR|PCSK9_ENST00000543384.1_Missense_Mutation_p.G27D	NM_174936.3	NP_777596.2	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	227	Peptidase S8.				cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(1)|liver(2)|lung(4)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	32						GACAGTCATGGCACCCACCTG	0.632000													94	221					0	0	0.003610	0	0
GNAI1	2770	broad.mit.edu	37	7	79764527	79764527	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:79764527G>C	ENST00000351004.3	+	1	424	c.51G>C	c.(49-51)aaG>aaC	p.K17N	GNAI1_ENST00000490206.1_3'UTR	NM_002069.5	NP_002060.4	P63096	GNAI1_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	17					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody|nucleus	G-protein beta/gamma-subunit complex binding|GTP binding|metabotropic serotonin receptor binding|signal transducer activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	19						AGCGGAGTAAGATGATCGACC	0.731000													4	38					0	0	0.000248	0	0
CELF5	60680	broad.mit.edu	37	19	3224881	3224881	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:3224881C>T	ENST00000541430.2	+	1	180	c.144C>T	c.(142-144)ttC>ttT	p.F48F	CELF5_ENST00000292672.2_Silent_p.F48F	NM_001172673.1	NP_001166144.1	Q8N6W0	CELF5_HUMAN	CUGBP, Elav-like family member 5	48	RRM 1.				mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)	13						TCAAACTCTTCGTGGGCCAGA	0.687000													7	16					0	0	0.003080	0	0
DDX17	10521	broad.mit.edu	37	22	38884057	38884057	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr22:38884057T>C	ENST00000396821.3	-	12	1610	c.1511A>G	c.(1510-1512)cAc>cGc	p.H504R	DDX17_ENST00000444597.1_5'UTR|DDX17_ENST00000381633.3_Missense_Mutation_p.H427R	NM_001098504.1|NM_006386.4	NP_001091974.1|NP_006377.2	Q92841	DDX17_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 17	425					RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	25	Melanoma(58;0.0286)					GCCAATACGGTGCACATAATC	0.478000													41	66					0	0	0.008740	0	0
C11orf85	283129	broad.mit.edu	37	11	64707209	64707209	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:64707209C>T	ENST00000536065.1	-	11	1627	c.323G>A	c.(322-324)cGa>cAa	p.R108Q	C11orf85_ENST00000530444.1_Missense_Mutation_p.R136Q|C11orf85_ENST00000301896.5_Missense_Mutation_p.E193K|C11orf85_ENST00000432175.1_Missense_Mutation_p.E193K			Q3KP22	CK085_HUMAN	chromosome 11 open reading frame 85	0										breast(2)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(2)	7						TGGGACAATTCGCCCTGGCAG	0.532000													34	58					0	0	0.003271	0	0
SHANK2	22941	broad.mit.edu	37	11	70332969	70332969	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:70332969G>A	ENST00000338508.4	-	32	3431	c.3432C>T	c.(3430-3432)tcC>tcT	p.S1144S	SHANK2_ENST00000449833.2_Silent_p.S548S|SHANK2_ENST00000423696.2_Silent_p.S764S|SHANK2_ENST00000409161.1_Silent_p.S547S			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	764					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TCGGCATGGGGGATGACAGCT	0.682000													18	40					0	0	0.007413	0	0
RCN3	57333	broad.mit.edu	37	19	50040373	50040373	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:50040373C>T	ENST00000270645.3	+	4	976	c.529C>T	c.(529-531)Cag>Tag	p.Q177*		NM_020650.2	NP_065701.2	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	177	EF-hand 3.					endoplasmic reticulum lumen	calcium ion binding|protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		GGTGGCCGACCAGGATGGGGA	0.602000													52	129					0	0	0.003610	0	0
FAR2P1	440905	broad.mit.edu	37	2	130792745	130792745	+	RNA	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:130792745G>A	ENST00000325390.3	-	0	2583					NR_026758.1																						ACAGCTAGTGGGAGATTGACG	0.488000													12	24					0	0	0.000978	0	0
TMEM104	54868	broad.mit.edu	37	17	72815924	72815924	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:72815924C>T	ENST00000335464.5	+	9	834	c.672C>T	c.(670-672)ttC>ttT	p.F224F	TMEM104_ENST00000417024.2_Silent_p.F237F|TMEM104_ENST00000582330.1_Silent_p.F224F|TMEM104_ENST00000582773.1_Silent_p.F224F	NM_017728.3	NP_060198.3	Q8NE00	TM104_HUMAN	transmembrane protein 104	224						integral to membrane				NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(5)|ovary(1)	19	all_lung(278;0.23)					CGTTCACCTTCTTTGACGTCC	0.557000													21	67					0	0	0.002299	0	0
UBE2Q1	55585	broad.mit.edu	37	1	154524607	154524607	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:154524607C>A	ENST00000292211.4	-	8	1007	c.928G>T	c.(928-930)Gaa>Taa	p.E310*		NM_017582.6	NP_060052.3	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q family member 1	310							ATP binding|protein binding|ubiquitin-protein ligase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCGGCTCCTTCTTTCTCTTTG	0.498000													24	120					1.04121e-07	1.17948e-07	0.005443	1	0
NAV2	89797	broad.mit.edu	37	11	20104680	20104680	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:20104680C>T	ENST00000396085.1	+	27	5823	c.5462C>T	c.(5461-5463)tCc>tTc	p.S1821F	NAV2_ENST00000360655.4_Missense_Mutation_p.S1754F|NAV2_ENST00000540292.1_Missense_Mutation_p.S1808F|NAV2_ENST00000349880.4_Missense_Mutation_p.S1818F|NAV2_ENST00000527559.2_Missense_Mutation_p.S1806F|NAV2_ENST00000396087.3_Missense_Mutation_p.S1877F|NAV2_ENST00000311043.8_Missense_Mutation_p.S882F|NAV2_ENST00000533917.1_Missense_Mutation_p.S882F	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1877						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						CACAATGGGTCCACAGGTTCC	0.488000													31	60					0	0	0.002836	0	0
ZNF514	84874	broad.mit.edu	37	2	95815791	95815791	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:95815791G>A	ENST00000295208.2	-	5	901	c.439C>T	c.(439-441)Ctt>Ttt	p.L147F	ZNF514_ENST00000411425.1_Missense_Mutation_p.L147F	NM_032788.1	NP_116177.1	Q96K75	ZN514_HUMAN	zinc finger protein 514	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(4)|lung(6)|urinary_tract(1)	11						TCTCTGCTAAGGGTGGTGGCA	0.428000													29	79					0	0	0.008361	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3140469	3140469	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr16:3140469G>A	ENST00000252463.2	-	5	888	c.801C>T	c.(799-801)tcC>tcT	p.S267S	ZSCAN10_ENST00000575108.1_5'UTR|ZSCAN10_ENST00000538082.2_Silent_p.S185S	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	267					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						TGCCAAGAAGGGACCCATCTT	0.642000													33	97					0	0	0.002445	0	0
GPCPD1	56261	broad.mit.edu	37	20	5566885	5566885	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr20:5566885G>A	ENST00000379019.4	-	5	474	c.262C>T	c.(262-264)Cac>Tac	p.H88Y		NM_019593.3	NP_062539.1	Q9NPB8	GPCP1_HUMAN	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	88	CBM20.|Substrate binding (Potential).				glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)	16						TCCCACTTGTGAACTATCACT	0.368000													21	85					0	0	0.002780	0	0
GPR98	84059	broad.mit.edu	37	5	89971227	89971227	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:89971227G>A	ENST00000405460.2	+	24	5374	c.5278G>A	c.(5278-5280)Gtg>Atg	p.V1760M	GPR98_ENST00000450321.2_3'UTR	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1760					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATTTAGAACAGTGTCCTTGAC	0.443000													6	20					0	0	0.003080	0	0
OR10W1	81341	broad.mit.edu	37	11	58034641	58034641	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:58034641G>A	ENST00000395079.2	-	1	1091	c.690C>T	c.(688-690)tcC>tcT	p.S230S		NM_207374.3	NP_997257.2	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W, member 1	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(1)	26		Breast(21;0.0589)				AAGAGCAGGTGGAGAAGGCCC	0.587000													31	56					0	0	0.001786	0	0
SFTA3	253970	broad.mit.edu	37	14	36960451	36960451	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:36960451G>A	ENST00000518529.2	-	2	763	c.88C>T	c.(88-90)Caa>Taa	p.Q30*	SFTA3_ENST00000518987.1_5'UTR|RP11-896J10.3_ENST00000521945.1_RNA	NM_001101341.1	NP_001094811.1	P0C7M3	SFTA3_HUMAN	surfactant associated 3	30										breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|skin(1)	7						CCTGATAATTGGAGCCATTCA	0.393000													4	11					0	0	0.000602	0	0
SLFN11	91607	broad.mit.edu	37	17	33690245	33690245	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:33690245G>A	ENST00000394566.1	-	4	854	c.582C>T	c.(580-582)ttC>ttT	p.F194F	SLFN11_ENST00000308377.4_Silent_p.F194F	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	194						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGTCTTTTTGGAAAATTAGGT	0.403000													42	103					0	0	0.002222	0	0
KIAA1377	57562	broad.mit.edu	37	11	101833617	101833617	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:101833617G>A	ENST00000263468.8	+	6	2121	c.1851G>A	c.(1849-1851)aaG>aaA	p.K617K	KIAA1377_ENST00000537689.1_Silent_p.K418K	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	617							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		AATTAACAAAGGAAAAAGGTG	0.313000													15	37					0	0	0.004007	0	0
OR6C70	390327	broad.mit.edu	37	12	55863568	55863568	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:55863568C>T	ENST00000327335.4	-	1	354	c.355G>A	c.(355-357)Gat>Aat	p.D119N	RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000555146.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA	NM_001005499.1	NP_001005499.1	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C, member 70	119					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	18						ACATAGCGATCATAGGACAGA	0.398000													21	34					0	0	0.001523	0	0
PPP4R4	57718	broad.mit.edu	37	14	94708704	94708704	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:94708704G>A	ENST00000304338.3	+	11	1379	c.1225G>A	c.(1225-1227)Gaa>Aaa	p.E409K		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	409						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						CCATGACCCTGAAGTACCAGT	0.383000													40	104					0	0	0.008740	0	0
SUPT16H	11198	broad.mit.edu	37	14	21821653	21821653	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:21821653G>A	ENST00000216297.2	-	25	3330	c.2992C>T	c.(2992-2994)Cga>Tga	p.R998*		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	998	Glu-rich (acidic).				DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		AAACCTTTTCGGGCTTCTTCC	0.348000													32	75					0	0	0.003755	0	0
SPIDR	23514	broad.mit.edu	37	8	48353042	48353042	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:48353042C>T	ENST00000297423.4	+	8	1419	c.1035C>T	c.(1033-1035)acC>acT	p.T345T	SPIDR_ENST00000541342.1_Silent_p.T275T|SPIDR_ENST00000521214.1_3'UTR|SPIDR_ENST00000518074.1_Silent_p.T285T	NM_001080394.2	NP_001073863.1			scaffolding protein involved in DNA repair																		TTCTCTTCACCAAGGAGACTG	0.582000													31	110					0	0	0.004289	0	0
DNAH10	196385	broad.mit.edu	37	12	124283838	124283838	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:124283838G>A	ENST00000409039.3	+	13	1880	c.1855G>A	c.(1855-1857)Gaa>Aaa	p.E619K		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	619	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GAAGGAGTATGAAGACAGAAA	0.443000													10	31					0	0	0.000978	0	0
LIMK2	3985	broad.mit.edu	37	22	31664134	31664134	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr22:31664134C>T	ENST00000331728.4	+	11	1379	c.1265C>T	c.(1264-1266)cCg>cTg	p.P422L	LIMK2_ENST00000406516.1_Missense_Mutation_p.P344L|LIMK2_ENST00000340552.4_Missense_Mutation_p.P401L|LIMK2_ENST00000333611.4_Missense_Mutation_p.P401L|LIMK2_ENST00000444929.2_Missense_Mutation_p.P176L	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	422	Protein kinase.					mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						CTGCAGGATCCGTTCCCCTGG	0.587000													30	87					0	0	0.003271	0	0
DNAH5	1767	broad.mit.edu	37	5	13931251	13931251	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:13931251C>T	ENST00000265104.4	-	2	264	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	54	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.E54K(2)		NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCCTCCACTTCGGTTTTGTTC	0.488000									Kartagener syndrome				17	60					0	0	0.006122	0	0
AFF3	3899	broad.mit.edu	37	2	100623390	100623390	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:100623390G>A	ENST00000317233.4	-	6	812	c.577C>T	c.(577-579)Ctt>Ttt	p.L193F	AFF3_ENST00000409579.1_Missense_Mutation_p.L218F|AFF3_ENST00000409236.1_Missense_Mutation_p.L193F|AFF3_ENST00000356421.2_Missense_Mutation_p.L218F	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	193					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TGGGTCTGAAGGCCCACCTCC	0.577000													26	57					0	0	0.004656	0	0
TIMD4	91937	broad.mit.edu	37	5	156349165	156349165	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:156349165G>A	ENST00000274532.2	-	7	1013	c.957C>T	c.(955-957)atC>atT	p.I319I	TIMD4_ENST00000407087.3_Silent_p.I291I|TIMD4_ENST00000406964.1_Silent_p.I21I	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	319						integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGGAGGGGGCGATGATCATCA	0.527000													102	260					0	0	0.003610	0	0
RANBP9	10048	broad.mit.edu	37	6	13642741	13642741	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr6:13642741C>T	ENST00000011619.3	-	7	1253	c.1195G>A	c.(1195-1197)Gaa>Aaa	p.E399K	RANBP9_ENST00000539980.1_Missense_Mutation_p.E170K	NM_005493.2	NP_005484.2	Q96S59	RANB9_HUMAN	RAN binding protein 9	399					axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	16	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			GCTAATTCTTCTAGAACGGTC	0.363000													17	28					0	0	0.004990	0	0
OR10J1	26476	broad.mit.edu	37	1	159410389	159410389	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:159410389G>A	ENST00000423932.3	+	1	878	c.841G>A	c.(841-843)Gac>Aac	p.D281N	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	281					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					CAGAGAACATGACCAGCTGAT	0.517000													22	121					0	0	0.002299	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159526	18159526	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:18159526C>T	ENST00000396275.2	+	3	1138	c.777C>T	c.(775-777)ttC>ttT	p.F259F		NM_054031.3	NP_473372.3	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	259						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						TTTCCATTTTCCTGTCCGCTC	0.493000													24	55					0	0	0.002780	0	0
MFSD4	148808	broad.mit.edu	37	1	205553197	205553197	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:205553197C>T	ENST00000367147.4	+	4	898	c.805C>T	c.(805-807)Cct>Tct	p.P269S	MFSD4_ENST00000539267.1_Missense_Mutation_p.P269S|MFSD4_ENST00000536357.1_Missense_Mutation_p.P182S	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	269					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			GGAGACACAGCCTCCTGAGAA	0.577000													4	118					0	0	0.000248	0	0
OR4C15	81309	broad.mit.edu	37	11	55322305	55322305	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:55322305C>T	ENST00000314644.2	+	1	523	c.523C>T	c.(523-525)Cgt>Tgt	p.R175C		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						GGCCTATGATCGTTATGTGGC	0.507000										HNSCC(20;0.049)			35	103					0	0	0.003755	0	0
CSMD3	114788	broad.mit.edu	37	8	113275983	113275983	+	Silent	SNP	G	G	A	rs61754530		TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:113275983G>A	ENST00000297405.5	-	61	9991	c.9747C>T	c.(9745-9747)ttC>ttT	p.F3249F	CSMD3_ENST00000343508.3_Silent_p.F3209F|CSMD3_ENST00000455883.2_Silent_p.F3080F|CSMD3_ENST00000352409.3_Silent_p.F3179F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3249	Sushi 25.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGCCCCAGTCGAAATTTGTTC	0.453000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			27	46					0	0	0.007291	0	0
CAGE1	285782	broad.mit.edu	37	6	7379053	7379053	+	Nonsense_Mutation	SNP	T	T	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr6:7379053T>A	ENST00000502583.1	-	4	1048	c.484A>T	c.(484-486)Aag>Tag	p.K162*	CAGE1_ENST00000512086.1_Nonsense_Mutation_p.K162*|CAGE1_ENST00000379918.4_Nonsense_Mutation_p.K162*|CAGE1_ENST00000509324.1_Intron|CAGE1_ENST00000296742.7_Nonsense_Mutation_p.K26*|CAGE1_ENST00000338150.4_Nonsense_Mutation_p.K162*	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	162										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					TTTTCTTCCTTAAATGAGTCT	0.378000													15	27					0	0	0.002450	0	0
CNTN4	152330	broad.mit.edu	37	3	2787249	2787249	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:2787249C>T	ENST00000397461.1	+	5	610	c.226C>T	c.(226-228)Cgc>Tgc	p.R76C	CNTN4_ENST00000418658.1_Missense_Mutation_p.R76C|CNTN4_ENST00000427331.1_Missense_Mutation_p.R76C	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	76	Ig-like C2-type 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TATGGATTTCCGCTACAGTGT	0.383000													27	91					0	0	0.007291	0	0
KIF20B	9585	broad.mit.edu	37	10	91497679	91497679	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr10:91497679C>T	ENST00000416354.1	+	20	3243	c.3171C>T	c.(3169-3171)gaC>gaT	p.D1057D	KIF20B_ENST00000478929.1_3'UTR|KIF20B_ENST00000260753.4_Silent_p.D987D|KIF20B_ENST00000394289.2_Silent_p.D1027D|KIF20B_ENST00000371728.3_Silent_p.D1027D			Q96Q89	KI20B_HUMAN	kinesin family member 20B	1027					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						CACAGTTAGACCTTTTAGGTA	0.338000													29	65					0	0	0.006320	0	0
NBPF1	55672	broad.mit.edu	37	1	16902870	16902870	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:16902870C>T	ENST00000430580.2	-	19	2898	c.2011G>A	c.(2011-2013)Gcc>Acc	p.A671T	NBPF1_ENST00000287968.8_Missense_Mutation_p.A36T|NBPF1_ENST00000432949.1_Missense_Mutation_p.A129T	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	671						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		GTGAGGAGGGCCTGGAGATGC	0.557000													73	771					0	0	0.003610	0	0
FAT4	79633	broad.mit.edu	37	4	126239235	126239235	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:126239235C>T	ENST00000394329.3	+	1	1682	c.1669C>T	c.(1669-1671)Cag>Tag	p.Q557*		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	557	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TGCCCGGGACCAGGGAGTTCA	0.517000											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	22					0	0	0.006122	0	0
MASP1	5648	broad.mit.edu	37	3	186954073	186954073	+	Missense_Mutation	SNP	G	G	A	rs142630054		TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:186954073G>A	ENST00000296280.6	-	11	1811	c.1586C>T	c.(1585-1587)tCg>tTg	p.S529L	MASP1_ENST00000392472.2_Missense_Mutation_p.S416L|MASP1_ENST00000337774.5_Intron|MASP1_ENST00000495249.1_5'UTR	NM_139125.3	NP_624302.1	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	528	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		GACTGCCCCCGATTTGTCTCG	0.567000													13	53					0	0	0.002450	0	0
GGCX	2677	broad.mit.edu	37	2	85777220	85777220	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:85777220T>C	ENST00000233838.3	-	15	2194	c.2114A>G	c.(2113-2115)aAt>aGt	p.N705S	GGCX_ENST00000430215.3_Missense_Mutation_p.N648S	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase	705					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	TAATATCAGATTTCGAAGTGA	0.463000													17	45					0	0	0.007413	0	0
BRD4	23476	broad.mit.edu	37	19	15383775	15383775	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:15383775G>A	ENST00000263377.2	-	2	357	c.136C>T	c.(136-138)Ccg>Tcg	p.P46S	BRD4_ENST00000371835.4_Missense_Mutation_p.P46S|BRD4_ENST00000360016.5_Missense_Mutation_p.P46S	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	46					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			TCTGGGGGCGGGGGGTTGGTG	0.557000			T	C15orf55	lethal midline carcinoma of young people								48	128					0	0	0.003610	0	0
PTPN14	5784	broad.mit.edu	37	1	214556993	214556993	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:214556993G>A	ENST00000366956.5	-	13	2399	c.2205C>T	c.(2203-2205)gcC>gcT	p.A735A	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	735					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		CCTGCAGCTGGGCACTGTACT	0.632000													13	89					0	0	0.001855	0	0
ZBED2	79413	broad.mit.edu	37	3	111312580	111312580	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:111312580C>T	ENST00000317012.4	-	2	1477	c.469G>A	c.(469-471)Gaa>Aaa	p.E157K	CD96_ENST00000352690.4_Intron|CD96_ENST00000438817.2_Intron|CD96_ENST00000283285.5_Intron	NM_024508.4	NP_078784.2	Q9BTP6	ZBED2_HUMAN	zinc finger, BED-type containing 2	157							DNA binding|metal ion binding			large_intestine(3)|lung(1)|skin(2)	6						ACCTCCTTTTCCCTTTGGCTG	0.627000													28	73					0	0	0.001786	0	0
ZNF35	7584	broad.mit.edu	37	3	44700266	44700266	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:44700266C>T	ENST00000296092.3	+	3	486	c.266C>T	c.(265-267)tCa>tTa	p.S89L	ZNF35_ENST00000453164.1_Missense_Mutation_p.S89L|ZNF35_ENST00000399560.2_Missense_Mutation_p.S89L|ZNF35_ENST00000396056.2_Silent_p.I137I|RP11-944L7.4_ENST00000457331.1_RNA|ZNF35_ENST00000542250.1_5'UTR			P13682	ZNF35_HUMAN	zinc finger protein 35	0	Globular domain.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	12		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		AACCCCTCATCATATCAGAAA	0.393000													17	49					0	0	0.004990	0	0
PPP4R4	57718	broad.mit.edu	37	14	94700961	94700961	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:94700961G>A	ENST00000304338.3	+	7	840	c.686G>A	c.(685-687)cGa>cAa	p.R229Q		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	229						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						TATGAAGTTCGATCTTGTATG	0.388000													9	34					0	0	0.000978	0	0
GCK	2645	broad.mit.edu	37	7	44190560	44190560	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:44190560C>T	ENST00000403799.3	-	4	947	c.478G>A	c.(478-480)Gat>Aat	p.D160N	GCK_ENST00000395796.3_Missense_Mutation_p.D159N|GCK_ENST00000437084.1_Missense_Mutation_p.D143N|GCK_ENST00000345378.2_Missense_Mutation_p.D161N	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	160					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						CCCACCTTATCGATGTCTTCG	0.567000													155	228					0	0	0.003610	0	0
ZNF384	171017	broad.mit.edu	37	12	6781621	6781621	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:6781621G>A	ENST00000396801.3	-	8	1196	c.989C>T	c.(988-990)tCc>tTc	p.S330F	ZNF384_ENST00000361959.3_Missense_Mutation_p.S330F|ZNF384_ENST00000396795.1_Intron|ZNF384_ENST00000319770.3_Intron|ZNF384_ENST00000396799.2_Intron|ZNF384_ENST00000355772.4_Intron	NM_001135734.2	NP_001129206.1	Q8TF68	ZN384_HUMAN	zinc finger protein 384	330					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						GGCCAGGTAGGAGGTGTTGGC	0.622000			T	"""EWSR1, TAF15 """	ALL								10	32					0	0	0.006214	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	39					0	0	0.004672	0	0
OR7D2	162998	broad.mit.edu	37	19	9296742	9296742	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:9296742G>A	ENST00000344248.2	+	1	464	c.285G>A	c.(283-285)atG>atA	p.M95I		NM_175883.2	NP_787079.1	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D, member 2	95					regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	20						TCTCCTACATGGACTGCCTCA	0.517000													30	104					0	0	0.002836	0	0
KCNB1	3745	broad.mit.edu	37	20	47991189	47991189	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr20:47991189C>T	ENST00000371741.4	-	2	1074	c.908G>A	c.(907-909)cGa>cAa	p.R303Q		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	303					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GCGGAGAATTCGCATGATGCG	0.532000													31	55					0	0	0.002445	0	0
ANK1	286	broad.mit.edu	37	8	41552191	41552191	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:41552191G>A	ENST00000396942.1	-	28	3329	c.3246C>T	c.(3244-3246)tcC>tcT	p.S1082S	ANK1_ENST00000265709.8_Silent_p.S1123S|ANK1_ENST00000347528.4_Silent_p.S1082S|ANK1_ENST00000379758.2_Silent_p.S1082S|ANK1_ENST00000396945.1_Silent_p.S1082S|ANK1_ENST00000352337.4_Silent_p.S1082S|ANK1_ENST00000289734.7_Silent_p.S1082S			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1082					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TGCTCTTCAGGGAGCCCCCTT	0.612000													22	49					0	0	0.002780	0	0
AQR	9716	broad.mit.edu	37	15	35212628	35212628	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr15:35212628T>A	ENST00000156471.5	-	14	1351	c.1126A>T	c.(1126-1128)Aca>Tca	p.T376S		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	376						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		TGGTGGAGTGTGTTTGAACTG	0.318000													6	17					0	0	0.003080	0	0
TELO2	9894	broad.mit.edu	37	16	1551436	1551436	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr16:1551436C>T	ENST00000262319.6	+	10	1576	c.1297C>T	c.(1297-1299)Ctg>Ttg	p.L433L		NM_016111.3	NP_057195.2	Q9Y4R8	TELO2_HUMAN	telomere maintenance 2	433						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding			NS(1)|endometrium(1)|kidney(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	19		Hepatocellular(780;0.219)				AGAGGATGAACTGAGCCTCGA	0.726000													11	21					0	0	0.008291	0	0
DDX60L	91351	broad.mit.edu	37	4	169354261	169354261	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:169354261A>T	ENST00000511577.1	-	11	1547	c.1300T>A	c.(1300-1302)Tcc>Acc	p.S434T	DDX60L_ENST00000260184.7_Missense_Mutation_p.S434T|DDX60L_ENST00000505890.1_Missense_Mutation_p.S434T			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	434							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TTTTCCAAGGAGATTTCTGAA	0.299000													6	13					0	0	0.001168	0	0
ZNF286B	729288	broad.mit.edu	37	17	18565894	18565894	+	Missense_Mutation	SNP	T	T	G			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:18565894T>G	ENST00000545289.1	-	5	1175	c.925A>C	c.(925-927)Aca>Cca	p.T309P		NM_001145045.1	NP_001138517.1	P0CG31	Z286B_HUMAN	zinc finger protein 286B	309					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(1)	2						GAGCTTTCTGTGAAGGTTTTC	0.383000													11	51					0	0	0.000978	0	0
IL13RA2	3598	broad.mit.edu	37	X	114245315	114245315	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chrX:114245315G>A	ENST00000371936.1	-	7	847	c.598C>T	c.(598-600)Ccc>Tcc	p.P200S	IL13RA2_ENST00000243213.1_Missense_Mutation_p.P200S			Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2	200	Fibronectin type-III 2.					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(6)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	23						TCCAAATAGGGAAATCTGCAT	0.368000													24	23					0	0	0.002299	0	0
ANK3	288	broad.mit.edu	37	10	61835104	61835104	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr10:61835104A>T	ENST00000280772.1	-	37	5726	c.5535T>A	c.(5533-5535)ttT>ttA	p.F1845L	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1845	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTGATTTTGTAAATGAATTAG	0.403000													42	63					0	0	0.002222	0	0
OR10K1	391109	broad.mit.edu	37	1	158435597	158435597	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:158435597G>A	ENST00000289451.2	+	1	326	c.246G>A	c.(244-246)ctG>ctA	p.L82L		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	82					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					CCAAGATGCTGGTTGACCTGC	0.483000													155	132					0	0	0.003610	0	0
BRCA2	675	broad.mit.edu	37	13	32950923	32950923	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr13:32950923C>T	ENST00000544455.1	+	21	8976	c.8749C>T	c.(8749-8751)Ctt>Ttt	p.L2917F	BRCA2_ENST00000380152.3_Missense_Mutation_p.L2917F	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2917					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CCCAGCTTACCTTGAGGTGAG	0.438000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			13	15					0	0	0.001368	0	0
MARS	4141	broad.mit.edu	37	12	57906612	57906612	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:57906612G>A	ENST00000262027.5	+	15	1966	c.1832G>A	c.(1831-1833)gGg>gAg	p.G611E	MARS_ENST00000315473.5_Missense_Mutation_p.G377E	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	611					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	CAGGACACGGGGATCCCTGCT	0.542000													39	116					0	0	0.006230	0	0
ASCC2	84164	broad.mit.edu	37	22	30221628	30221628	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr22:30221628C>T	ENST00000397771.2	-	4	400	c.223G>A	c.(223-225)Gat>Aat	p.D75N	ASCC2_ENST00000307790.3_Missense_Mutation_p.D75N|ASCC2_ENST00000542393.1_Intron			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	75					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			CAGAATTTATCGTGAGGCAAG	0.502000													34	70					0	0	0.002445	0	0
EIF2B1	1967	broad.mit.edu	37	12	124111662	124111662	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:124111662G>A	ENST00000424014.2	-	5	619	c.411C>T	c.(409-411)gtC>gtT	p.V137V	EIF2B1_ENST00000539951.1_Silent_p.V124V|EIF2B1_ENST00000537073.1_Silent_p.V137V	NM_001414.3	NP_001405.1	Q14232	EI2BA_HUMAN	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	137					cellular response to stimulus|oligodendrocyte development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex|membrane fraction|plasma membrane	protein binding|translation initiation factor activity			breast(1)|kidney(3)|large_intestine(2)|lung(3)|urinary_tract(1)	10	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.67e-05)|Epithelial(86;0.000353)|all cancers(50;0.00489)		CTGCTTCCAGGACTCTCAGGA	0.527000													21	77					0	0	0.002299	0	0
DOK7	285489	broad.mit.edu	37	4	3478206	3478206	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:3478206C>T	ENST00000340083.5	+	4	534	c.469C>T	c.(469-471)Ctc>Ttc	p.L157F	DOK7_ENST00000507039.1_Missense_Mutation_p.L157F|DOK7_ENST00000389653.2_Missense_Mutation_p.L157F	NM_173660.4	NP_775931.3	Q18PE1	DOK7_HUMAN	docking protein 7	157	IRS-type PTB.				positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			kidney(1)|large_intestine(1)|skin(2)|upper_aerodigestive_tract(1)	5				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GCTGTCTGACCTCCGGCGCTA	0.637000													23	70					0	0	0.002299	0	0
NAGA	4668	broad.mit.edu	37	22	42456971	42456971	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr22:42456971G>A	ENST00000396398.3	-	8	1590	c.1058C>T	c.(1057-1059)tCc>tTc	p.S353F	NAGA_ENST00000402937.1_Missense_Mutation_p.S353F|NAGA_ENST00000403363.1_Missense_Mutation_p.S353F	NM_000262.2	NP_000253.1	P17050	NAGAB_HUMAN	N-acetylgalactosaminidase, alpha-	353					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						GCCAAGGGAGGAGTGGTAGCG	0.557000													20	63					0	0	0.002299	0	0
LTBP2	4053	broad.mit.edu	37	14	74968203	74968203	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:74968203C>T	ENST00000261978.4	-	35	5647	c.5261G>A	c.(5260-5262)gGc>gAc	p.G1754D	LTBP2_ENST00000556690.1_Missense_Mutation_p.G1710D	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1754	EGF-like 19; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		ACAGGTGTAGCCCTCCCGCAC	0.632000											OREG0022805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	81					0	0	0.002096	0	0
CLCN6	1185	broad.mit.edu	37	1	11896130	11896130	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:11896130C>T	ENST00000346436.6	+	18	1952	c.1900C>T	c.(1900-1902)Ccg>Tcg	p.P634S	CLCN6_ENST00000376496.3_Missense_Mutation_p.P634S|CLCN6_ENST00000376487.3_Missense_Mutation_p.P612S|CLCN6_ENST00000312413.6_3'UTR	NM_001286.3	NP_001277.1	P51797	CLCN6_HUMAN	chloride channel, voltage-sensitive 6	634	CBS 1.				cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(4)	36	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CCATGCCTTCCCGGTGGTCAC	0.557000													7	22					0	0	0.001984	0	0
ZBTB49	166793	broad.mit.edu	37	4	4322648	4322648	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:4322648C>T	ENST00000337872.4	+	8	2024	c.1903C>T	c.(1903-1905)Cac>Tac	p.H635Y	ZBTB49_ENST00000538529.1_Missense_Mutation_p.H118Y|ZBTB49_ENST00000355834.3_Missense_Mutation_p.H513Y	NM_145291.3	NP_660334.3	Q6ZSB9	ZBT49_HUMAN	zinc finger and BTB domain containing 49	635					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						ACTCCCTGTCCACCCAGTGGA	0.512000													13	31					0	0	0.001368	0	0
LTBP1	4052	broad.mit.edu	37	2	33518321	33518321	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:33518321C>T	ENST00000404816.2	+	20	3560	c.3207C>T	c.(3205-3207)acC>acT	p.T1069T	LTBP1_ENST00000404525.1_Silent_p.T690T|LTBP1_ENST00000407925.1_Silent_p.T743T|LTBP1_ENST00000390003.4_Silent_p.T744T|LTBP1_ENST00000272273.5_Silent_p.T9T|LTBP1_ENST00000498013.1_3'UTR|LTBP1_ENST00000354476.3_Silent_p.T1070T|LTBP1_ENST00000418533.2_Silent_p.T743T|LTBP1_ENST00000402934.1_Silent_p.T690T			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1069	EGF-like 8; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AAGGCTATACCCGGACTCCGG	0.418000													7	30					0	0	0.006214	0	0
SLC16A14	151473	broad.mit.edu	37	2	230914547	230914547	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:230914547G>A	ENST00000295190.4	-	3	791	c.333C>T	c.(331-333)tcC>tcT	p.S111S		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	111						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		CCCAGCCCAGGGAGTTGACGA	0.488000													30	65					0	0	0.003271	0	0
VPRBP	9730	broad.mit.edu	37	3	51440680	51440680	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:51440680G>A	ENST00000335891.5	-	16	3024	c.3015C>T	c.(3013-3015)ttC>ttT	p.F1005F				Q9Y4B6	VPRBP_HUMAN	Vpr (HIV-1) binding protein	1454					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		CAGAGGGAGAGAAGTCATTGT	0.537000													9	17					0	0	0.004482	0	0
CDH10	1008	broad.mit.edu	37	5	24537654	24537654	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:24537654C>T	ENST00000264463.4	-	3	868	c.361G>A	c.(361-363)Gaa>Aaa	p.E121K		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	121	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AAGGCCTTTTCCTCCCTATCA	0.383000										HNSCC(23;0.051)			30	71					0	0	0.008361	0	0
OR8J1	219477	broad.mit.edu	37	11	56127730	56127730	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:56127730C>T	ENST00000303039.3	+	1	40	c.8C>T	c.(7-9)cCt>cTt	p.P3L		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	3					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					GACATGGCTCCTGAAAATTTC	0.433000													20	64					0	0	0.008871	0	0
KIF3A	11127	broad.mit.edu	37	5	132038599	132038599	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:132038599C>T	ENST00000378746.4	-	11	1762	c.1544G>A	c.(1543-1545)cGc>cAc	p.R515H	KIF3A_ENST00000487055.1_5'UTR|KIF3A_ENST00000378735.1_Missense_Mutation_p.R518H|AC004237.1_ENST00000431165.1_RNA|KIF3A_ENST00000403231.1_Missense_Mutation_p.R542H	NM_007054.5	NP_008985.3	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	515					blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding	p.R515H(1)		endometrium(1)|kidney(4)|large_intestine(8)|lung(3)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	25		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAGTTCTCTGCGAAGTTGCTC	0.388000													52	151					0	0	0.003610	0	0
DNAH3	55567	broad.mit.edu	37	16	21049241	21049241	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr16:21049241G>A	ENST00000261383.3	-	34	4791	c.4792C>T	c.(4792-4794)Cac>Tac	p.H1598Y	DNAH3_ENST00000415178.1_Missense_Mutation_p.H1598Y	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1598	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TAGTCATAGTGATGCTGAGAG	0.542000													10	29					0	0	0.008291	0	0
MGAT5B	146664	broad.mit.edu	37	17	74922712	74922712	+	Silent	SNP	G	G	A	rs144217759		TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:74922712G>A	ENST00000569840.2	+	10	1765	c.1191G>A	c.(1189-1191)acG>acA	p.T397T	MGAT5B_ENST00000301618.4_Silent_p.T397T|MGAT5B_ENST00000428789.2_Silent_p.T408T	NM_001199172.1	NP_001186101.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	397						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CCTTCGGGACGGAACCTGCGT	0.622000													11	32					0	0	0.008291	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156632310	156632310	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:156632310C>T	ENST00000296518.7	+	6	1202	c.993C>T	c.(991-993)atC>atT	p.I331I	GUCY1A3_ENST00000511108.1_Silent_p.I331I|GUCY1A3_ENST00000511507.1_Silent_p.I331I|GUCY1A3_ENST00000455639.2_Silent_p.I331I|GUCY1A3_ENST00000393832.3_Silent_p.I73I|GUCY1A3_ENST00000506455.1_Silent_p.I331I|GUCY1A3_ENST00000513574.1_Silent_p.I331I			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	331					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CTCCAAAAATCAACCAGACGT	0.398000													19	44					0	0	0.007413	0	0
COL12A1	1303	broad.mit.edu	37	6	75833060	75833060	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr6:75833060G>A	ENST00000322507.8	-	43	7241	c.6932C>T	c.(6931-6933)cCa>cTa	p.P2311L	COL12A1_ENST00000483888.2_Missense_Mutation_p.P2311L|COL12A1_ENST00000416123.2_Missense_Mutation_p.P2311L|COL12A1_ENST00000345356.6_Missense_Mutation_p.P1147L	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2311					cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CCGGGCTGGTGGAATGGTGGG	0.428000													4	8					0	0	0.000248	0	0
SPRR3	6707	broad.mit.edu	37	1	152975920	152975920	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:152975920C>T	ENST00000331860.3	+	3	574	c.424C>T	c.(424-426)Cct>Tct	p.P142S	SPRR3_ENST00000295367.4_Missense_Mutation_p.P142S|SPRR3_ENST00000542696.1_Missense_Mutation_p.P134S	NM_005416.2	NP_005407.1	Q9UBC9	SPRR3_HUMAN	small proline-rich protein 3	142	14 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	11	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACCAAAGTTCCTGTGCCAGG	0.532000													25	20					0	0	0.002780	0	0
TNFRSF11A	8792	broad.mit.edu	37	18	60015474	60015474	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr18:60015474G>A	ENST00000586569.1	+	2	187	c.149G>A	c.(148-150)tGt>tAt	p.C50Y	TNFRSF11A_ENST00000269485.7_Missense_Mutation_p.C50Y	NM_003839.2	NP_003830.1	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	50					adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(13)|skin(3)|upper_aerodigestive_tract(1)	29		Colorectal(73;0.188)				TGTAACAAATGTGAACCAGGT	0.463000													23	35					0	0	0.003330	0	0
ANPEP	290	broad.mit.edu	37	15	90347724	90347724	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr15:90347724G>A	ENST00000300060.6	-	5	1335	c.1022C>T	c.(1021-1023)tCa>tTa	p.S341L		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	341	Interaction with HCoV-229E.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	CCACTCACCTGATTTTGGGAG	0.597000													31	74					0	0	0.002445	0	0
TAS2R10	50839	broad.mit.edu	37	12	10977959	10977959	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:10977959G>A	ENST00000240619.2	-	1	998	c.910C>T	c.(910-912)Ctc>Ttc	p.L304F		NM_023921.1	NP_076410.1	Q9NYW0	T2R10_HUMAN	taste receptor, type 2, member 10	304					sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						GTGACTCTGAGATTTTTCCTT	0.418000													14	44					0	0	0.003163	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140616248	140616248	+	RNA	SNP	T	T	C			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:140616248T>C	ENST00000526308.1	+	0	2311					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						GGTGTTCCTGTTCGTGGCGGT	0.682000													44	93					0	0	0.003610	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40837275	40837275	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:40837275C>T	ENST00000264638.4	+	5	769	c.552C>T	c.(550-552)tcC>tcT	p.S184S	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	184					axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		ATGCCATCTCCTACCGCTTCC	0.652000													19	43					0	0	0.001882	0	0
CEP120	153241	broad.mit.edu	37	5	122714084	122714084	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:122714084T>A	ENST00000306467.5	-	15	2446	c.2142A>T	c.(2140-2142)aaA>aaT	p.K714N	CEP120_ENST00000328236.5_Missense_Mutation_p.K714N|CEP120_ENST00000306481.6_Missense_Mutation_p.K688N			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	714						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						CAATTAGAGTTTTTTGAAGTT	0.343000													36	82					0	0	0.003271	0	0
OR1A1	8383	broad.mit.edu	37	17	3119691	3119691	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:3119691C>T	ENST00000304094.1	+	1	777	c.777C>T	c.(775-777)ttC>ttT	p.F259F		NM_014565.2	NP_055380.2	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A, member 1	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	23						GCACGTATTTCCGCCCTTTGA	0.478000													28	93					0	0	0.004656	0	0
TTC29	83894	broad.mit.edu	37	4	147830395	147830395	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:147830395C>T	ENST00000513335.1	-	6	460	c.261G>A	c.(259-261)agG>agA	p.R87R	TTC29_ENST00000398886.4_Silent_p.R87R|TTC29_ENST00000325106.4_Silent_p.R61R			Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	61							binding			breast(2)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					TGTAGGAGTTCCTATAACTGG	0.413000													3	11					0	0	0.004672	0	0
WDFY3	23001	broad.mit.edu	37	4	85724537	85724537	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:85724537G>C	ENST00000322366.6	-	16	2920	c.2513C>G	c.(2512-2514)tCt>tGt	p.S838C	WDFY3_ENST00000295888.4_Missense_Mutation_p.S838C|WDFY3_ENST00000512267.1_5'UTR|WDFY3-AS1_ENST00000510449.1_RNA			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	838						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		ACTCTGCAGAGATGAAGTTGT	0.458000													7	39					0	0	0.001984	0	0
ADAM30	11085	broad.mit.edu	37	1	120437405	120437405	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:120437405G>A	ENST00000369400.1	-	1	1713	c.1555C>T	c.(1555-1557)Cct>Tct	p.P519S		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	519	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CACTCACTAGGAGCCTCCATG	0.418000													167	424					0	0	0.003610	0	0
TCERG1	10915	broad.mit.edu	37	5	145883447	145883447	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:145883447C>T	ENST00000296702.5	+	18	2646	c.2608C>T	c.(2608-2610)Cga>Tga	p.R870*	TCERG1_ENST00000394421.2_Nonsense_Mutation_p.R849*|TCERG1_ENST00000509787.1_3'UTR	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	870					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGCAAGCCTTCGAGAACGAGA	0.418000													19	61					0	0	0.001523	0	0
KDM1A	23028	broad.mit.edu	37	1	23384007	23384007	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:23384007C>T	ENST00000400181.4	+	8	1125	c.1021C>T	c.(1021-1023)Cgc>Tgc	p.R341C	RP1-184J9.2_ENST00000427154.1_RNA|KDM1A_ENST00000542151.1_Missense_Mutation_p.R341C|KDM1A_ENST00000356634.3_Missense_Mutation_p.R321C	NM_001009999.2	NP_001009999.1	O60341	KDM1A_HUMAN	lysine (K)-specific demethylase 1A	321	Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(2)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TGCCACATTTCGCAAAGGAAA	0.413000													32	64					0	0	0.004289	0	0
GPR98	84059	broad.mit.edu	37	5	89938699	89938699	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:89938699C>T	ENST00000405460.2	+	13	2490	c.2394C>T	c.(2392-2394)atC>atT	p.I798I		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	798					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGCTCCACATCATCCGATCAA	0.398000													38	131					0	0	0.006999	0	0
IGFN1	91156	broad.mit.edu	37	1	201193886	201193886	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:201193886G>A	ENST00000335211.4	+	21	10500	c.10370G>A	c.(10369-10371)gGc>gAc	p.G3457D	IGFN1_ENST00000295591.8_Intron	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						ACTAAGGATGGCCTCACCCAG	0.572000													7	46					0	0	0.003080	0	0
FLNC	2318	broad.mit.edu	37	7	128489437	128489437	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:128489437G>A	ENST00000325888.8	+	30	5265	c.5004G>A	c.(5002-5004)gtG>gtA	p.V1668V	FLNC_ENST00000346177.6_Silent_p.V1668V	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1668				V -> M (in Ref. 3; CAB46442).	cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TGATCACGGTGGATGCCAAGG	0.637000													15	48					0	0	0.002450	0	0
WDR91	29062	broad.mit.edu	37	7	134891950	134891950	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:134891950G>A	ENST00000354475.4	-	4	547	c.516C>T	c.(514-516)gtC>gtT	p.V172V	WDR91_ENST00000344400.5_Silent_p.V172V|WDR91_ENST00000423565.1_Silent_p.V137V	NM_014149.3	NP_054868.3	A4D1P6	WDR91_HUMAN	WD repeat domain 91	172										breast(3)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	40						GGATCACAGGGACTGGTGCAC	0.463000													22	76					0	0	0.002299	0	0
TSFM	10102	broad.mit.edu	37	12	58190272	58190272	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:58190272C>T	ENST00000454289.3	+	6	1097	c.884C>T	c.(883-885)aCc>aTc	p.T295I	TSFM_ENST00000323833.8_Missense_Mutation_p.T316I|TSFM_ENST00000550559.1_Intron|TSFM_ENST00000350762.5_Missense_Mutation_p.T255I|TSFM_ENST00000548851.1_Intron|TSFM_ENST00000540550.1_3'UTR|TSFM_ENST00000543727.1_Intron	NM_005726.5	NP_005717.3	P43897	EFTS_HUMAN	Ts translation elongation factor, mitochondrial	295					regulation of transcription elongation, DNA-dependent	mitochondrion|nucleus	translation elongation factor activity			endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)	8	all_cancers(7;6.31e-80)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					CCCTCCATTACCTTGGGGCAG	0.562000													4	11					0	0	0.000602	0	0
ODF3	113746	broad.mit.edu	37	11	198517	198517	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:198517G>A	ENST00000325113.4	+	5	783	c.466G>A	c.(466-468)Gcc>Acc	p.A156T	BET1L_ENST00000410108.1_Intron|ODF3_ENST00000525282.1_Missense_Mutation_p.A156T	NM_053280.3	NP_444510.2	Q96PU9	ODF3A_HUMAN	outer dense fiber of sperm tails 3	156					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm				biliary_tract(1)|breast(1)|kidney(1)|large_intestine(2)|ovary(1)|prostate(2)|skin(1)	9		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CGTCGGCAAGGCCTCCCAGCC	0.642000													16	40					0	0	0.003163	0	0
BAG6	7917	broad.mit.edu	37	6	31611729	31611729	+	Missense_Mutation	SNP	G	G	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr6:31611729G>T	ENST00000404765.2	-	14	1983	c.1694C>A	c.(1693-1695)gCc>gAc	p.A565D	BAG6_ENST00000439687.2_Missense_Mutation_p.A528D|BAG6_ENST00000470875.1_5'UTR|BAG6_ENST00000211379.5_Missense_Mutation_p.A529D|BAG6_ENST00000375964.6_Missense_Mutation_p.A535D|BAG6_ENST00000362049.6_Missense_Mutation_p.A529D|BAG6_ENST00000375976.4_Missense_Mutation_p.A529D			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	535	4 X 29 AA approximate repeats.|Pro-rich.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						GGCCAACGAGGCATTGGTACC	0.552000													43	236					1.86633e-21	2.1315e-21	0.003610	1	0
FBXW12	285231	broad.mit.edu	37	3	48415089	48415089	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:48415089G>A	ENST00000296438.5	+	4	366	c.180G>A	c.(178-180)ctG>ctA	p.L60L	FBXW12_ENST00000445170.1_Silent_p.L41L|FBXW12_ENST00000415155.1_Silent_p.L60L|FBXW12_ENST00000436231.1_Intron	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	60										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ATCAACACCTGGGCACACACA	0.473000													13	62					0	0	0.001855	0	0
MROH7	374977	broad.mit.edu	37	1	55148375	55148375	+	Missense_Mutation	SNP	T	T	G			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:55148375T>G	ENST00000414150.2	+	14	2706	c.2428T>G	c.(2428-2430)Tgt>Ggt	p.C810G	MROH7_ENST00000339553.5_Missense_Mutation_p.C810G|MROH7_ENST00000545244.1_Missense_Mutation_p.C378G|MROH7_ENST00000454855.2_Missense_Mutation_p.C328G|MROH7_ENST00000421030.2_Missense_Mutation_p.C810G|MROH7_ENST00000409996.1_Missense_Mutation_p.C378G|MROH7_ENST00000395690.2_Missense_Mutation_p.C810G					maestro heat-like repeat family member 7																		TAAGCCCAGCTGTGATGTCCG	0.612000													20	55					0	0	0.007413	0	0
FUT9	10690	broad.mit.edu	37	6	96651676	96651676	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr6:96651676C>T	ENST00000302103.5	+	3	971	c.645C>T	c.(643-645)atC>atT	p.I215I		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	215					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		GCATTGAAATCCATACCTACG	0.373000													14	19					0	0	0.002450	0	0
AHDC1	27245	broad.mit.edu	37	1	27875201	27875201	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:27875201G>A	ENST00000374011.2	-	6	4394	c.3426C>T	c.(3424-3426)atC>atT	p.I1142I	AHDC1_ENST00000482400.2_Intron|AHDC1_ENST00000247087.5_Silent_p.I1142I	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1142							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		AGATGTCCAGGATCACGTTGG	0.572000													18	68					0	0	0.001523	0	0
ABCC6	368	broad.mit.edu	37	16	16276350	16276350	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr16:16276350C>T	ENST00000205557.7	-	17	2195	c.2166G>A	c.(2164-2166)ctG>ctA	p.L722L	ABCC6_ENST00000574094.1_Intron	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	722	ABC transporter 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		GTACTCTCTCCAGCCAGGGTG	0.587000													23	27					0	0	0.002299	0	0
ABCD4	5826	broad.mit.edu	37	14	74764666	74764666	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:74764666G>A	ENST00000356924.4	-	4	535	c.392C>T	c.(391-393)aCc>aTc	p.T131I	ABCD4_ENST00000557554.1_Intron|ABCD4_ENST00000557588.1_Missense_Mutation_p.T131I|ABCD4_ENST00000298816.7_Missense_Mutation_p.T44I	NM_005050.3	NP_005041.1	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D (ALD), member 4	131	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			cervix(2)|endometrium(3)|kidney(3)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00153)		CACGTTGAGGGTGTAGTACGC	0.567000													21	52					0	0	0.001882	0	0
ALG9	79796	broad.mit.edu	37	11	111707007	111707007	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:111707007G>A	ENST00000398006.2	-	13	1857	c.949C>T	c.(949-951)Cag>Tag	p.Q317*	ALG9_ENST00000527228.1_5'UTR|ALG9_ENST00000531154.1_Nonsense_Mutation_p.Q324*|ALG9_ENST00000524880.1_3'UTR	NM_001077690.1|NM_001077691.1|NM_001077692.1	NP_001071158.1|NP_001071159.1|NP_001071160.1	Q9H6U8	ALG9_HUMAN	ALG9, alpha-1,2-mannosyltransferase	488					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		GGAATGAACTGAAGCTGCCAA	0.418000													13	28					0	0	0.001855	0	0
ANGEL1	23357	broad.mit.edu	37	14	77269744	77269744	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:77269744G>A	ENST00000251089.2	-	7	1700	c.1588C>T	c.(1588-1590)Ctt>Ttt	p.L530F	ANGEL1_ENST00000557179.1_Missense_Mutation_p.L95F	NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	530										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		CCTTCCATAAGGACCAGTCCT	0.473000													8	53					0	0	0.006214	0	0
TLR6	10333	broad.mit.edu	37	4	38828821	38828821	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:38828821C>T	ENST00000436693.2	-	2	2393	c.2274G>A	c.(2272-2274)cgG>cgA	p.R758R	TLR6_ENST00000381950.1_Silent_p.R758R	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	758	TIR.				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GCAAATAAGTCCGCTGCGTCA	0.428000													33	100					0	0	0.003755	0	0
PTPN14	5784	broad.mit.edu	37	1	214556992	214556992	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:214556992G>A	ENST00000366956.5	-	13	2400	c.2206C>T	c.(2206-2208)Cag>Tag	p.Q736*	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	736					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GCCTGCAGCTGGGCACTGTAC	0.632000													12	91					0	0	0.001368	0	0
MYH2	4620	broad.mit.edu	37	17	10427143	10427143	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:10427143C>T	ENST00000245503.5	-	36	5618	c.5234G>A	c.(5233-5235)gGa>gAa	p.G1745E	CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.G1745E	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1745					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CTCCATCTCTCCTTGCATTTG	0.433000													13	61					0	0	0.001855	0	0
MAP1LC3C	440738	broad.mit.edu	37	1	242159558	242159558	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:242159558C>T	ENST00000357246.3	-	4	415	c.351G>A	c.(349-351)atG>atA	p.M117I		NM_001004343.2	NP_001004343.1	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3 gamma	117					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			AGGCGTAGGTCATGTACACGA	0.552000													29	131					0	0	0.002096	0	0
CILP2	148113	broad.mit.edu	37	19	19655800	19655800	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:19655800G>A	ENST00000586018.1	+	8	2566	c.2464G>A	c.(2464-2466)Gag>Aag	p.E822K	CILP2_ENST00000291495.4_Missense_Mutation_p.E816K			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	816						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						CCTGGGCGGCGAGGAGCTGGA	0.746000													11	10					0	0	0.008291	0	0
USP17L2	377630	broad.mit.edu	37	8	11996046	11996046	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:11996046G>A	ENST00000333796.3	-	1	540	c.224C>T	c.(223-225)cCt>cTt	p.P75L	FAM66D_ENST00000434078.2_RNA	NM_001256869.1|NM_001256871.1|NM_001256872.1|NM_001256873.1|NM_001256874.1|NM_201402.2	NP_001243798.1|NP_001243800.1|NP_001243801.1|NP_001243802.1|NP_001243803.1|NP_958804.2	Q6R6M4	U17L2_HUMAN	ubiquitin specific peptidase 17-like family member 2	75					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(1)|kidney(1)|large_intestine(11)|liver(1)|lung(8)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	29						CACCGCAGCAGGTCTCCTGCT	0.572000													18	255					0	0	0.002299	0	0
SP140	11262	broad.mit.edu	37	2	231155263	231155263	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:231155263G>A	ENST00000392045.3	+	19	1923	c.1809G>A	c.(1807-1809)aaG>aaA	p.K603K	SP140_ENST00000486687.2_Silent_p.K527K|SP140_ENST00000420434.3_Silent_p.K576K|SP140_ENST00000350136.5_Silent_p.K472K|SP140_ENST00000417495.3_Silent_p.K489K|SP140_ENST00000343805.6_Silent_p.K543K	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	603	SAND.				defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TTTTACATAAGAAGAAATTGC	0.408000													20	46					0	0	0.001882	0	0
HMCES	56941	broad.mit.edu	37	3	129007776	129007776	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:129007776C>T	ENST00000383463.4	+	3	352	c.263C>T	c.(262-264)tCc>tTc	p.S88F	C3orf37_ENST00000389735.3_Missense_Mutation_p.S88F|C3orf37_ENST00000417226.2_Missense_Mutation_p.S88F|C3orf37_ENST00000502878.2_Missense_Mutation_p.S88F	NM_020187.2	NP_064572.2	Q96FZ2	CC037_HUMAN		88										breast(1)|endometrium(1)|kidney(2)|lung(5)|ovary(1)|urinary_tract(4)	14						AGTGATCCTTCCAAGCTGCAG	0.488000													20	67					0	0	0.001882	0	0
PCDH15	65217	broad.mit.edu	37	10	55626419	55626419	+	Missense_Mutation	SNP	C	C	T	rs143149062		TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr10:55626419C>T	ENST00000373965.2	-	28	4115	c.3721G>A	c.(3721-3723)Ggc>Agc	p.G1241S	PCDH15_ENST00000437009.1_Missense_Mutation_p.G1163S|PCDH15_ENST00000395438.1_Missense_Mutation_p.G1234S|PCDH15_ENST00000409834.1_Missense_Mutation_p.G845S|PCDH15_ENST00000414778.1_Missense_Mutation_p.G1239S|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.G1212S|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395432.2_Missense_Mutation_p.G1197S|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000320301.6_Missense_Mutation_p.G1234S|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395445.1_Missense_Mutation_p.G1241S|PCDH15_ENST00000395430.1_Missense_Mutation_p.G1234S|PCDH15_ENST00000361849.3_Missense_Mutation_p.G1234S|PCDH15_ENST00000395446.1_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1234	Cadherin 11.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TCGGCTTTGCCGCTCAGTCCC	0.408000										HNSCC(58;0.16)			14	20					0	0	0.003163	0	0
NCKAP5	344148	broad.mit.edu	37	2	133489532	133489532	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:133489532G>A	ENST00000409261.1	-	17	5594	c.5221C>T	c.(5221-5223)Cag>Tag	p.Q1741*	NCKAP5_ENST00000409213.1_Nonsense_Mutation_p.Q422*|NCKAP5_ENST00000405974.3_Nonsense_Mutation_p.Q422*|NCKAP5_ENST00000473859.1_5'UTR|NCKAP5_ENST00000317721.6_Nonsense_Mutation_p.Q1741*	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1741							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						GAGTCTGGCTGGCATAGGTAG	0.552000													25	37					0	0	0.003330	0	0
SLC44A5	204962	broad.mit.edu	37	1	75685026	75685026	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:75685026G>A	ENST00000370855.5	-	16	1295	c.1182C>T	c.(1180-1182)ttC>ttT	p.F394F	SLC44A5_ENST00000370859.3_Silent_p.F394F|SLC44A5_ENST00000535611.1_Silent_p.F264F	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	394						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						ATGTCGCCAAGAAACTGAATA	0.383000													11	29					0	0	0.008291	0	0
UNC13C	440279	broad.mit.edu	37	15	54919039	54919039	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr15:54919039G>A	ENST00000545554.1	+	32	6373	c.6373G>A	c.(6373-6375)Gaa>Aaa	p.E2125K	UNC13C_ENST00000539562.2_Missense_Mutation_p.E46K|UNC13C_ENST00000537900.1_Missense_Mutation_p.E2123K|UNC13C_ENST00000260323.11_Missense_Mutation_p.E2125K			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	2125	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TCTCGGAAAGGAAAATCGACC	0.378000													13	41					0	0	0.002450	0	0
FSHR	2492	broad.mit.edu	37	2	49190690	49190690	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:49190690G>A	ENST00000406846.2	-	10	1389	c.1270C>T	c.(1270-1272)Cat>Tat	p.H424Y	FSHR_ENST00000346173.3_Missense_Mutation_p.H362Y|FSHR_ENST00000541117.1_Missense_Mutation_p.H160Y|FSHR_ENST00000304421.4_Missense_Mutation_p.H398Y	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	424					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	CTCTTGGTATGGATATCAACT	0.478000									Gonadal Dysgenesis, 46 XX				11	52					0	0	0.000978	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508103	37508103	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr10:37508103G>A	ENST00000374660.1	+	40	3751	c.3652G>A	c.(3652-3654)Gaa>Aaa	p.E1218K	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E1099K|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E1099K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1170						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ACTGAAAGAGGAATCATTAAC	0.338000													52	103					0	0	0.003610	0	0
FER1L6	654463	broad.mit.edu	37	8	125058037	125058037	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:125058037G>A	ENST00000522917.1	+	21	2825	c.2619G>A	c.(2617-2619)tgG>tgA	p.W873*	FER1L6_ENST00000399018.1_Nonsense_Mutation_p.W873*	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	873	C2 3.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CTCCGACCTGGAACCAGATGC	0.502000													65	234					0	0	0.003610	0	0
IRAK2	3656	broad.mit.edu	37	3	10254984	10254984	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:10254984G>A	ENST00000256458.4	+	5	712	c.622G>A	c.(622-624)Gat>Aat	p.D208N		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	208					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						CCAGGCAACCGATGACTTCAA	0.522000													19	56					0	0	0.006122	0	0
CREB3	10488	broad.mit.edu	37	9	35733137	35733137	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr9:35733137C>T	ENST00000353704.2	+	2	712	c.274C>T	c.(274-276)Cta>Tta	p.L92L	CREB3_ENST00000486056.1_3'UTR	NM_006368.4	NP_006359.3	O43889	CREB3_HUMAN	cAMP responsive element binding protein 3	92	Transcription activation (acidic).				chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|nucleus	cAMP response element binding protein binding|CCR1 chemokine receptor binding|DNA binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|urinary_tract(1)	9	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		CTCTATGGATCTAGGTGAGTC	0.532000													19	17					0	0	0.006122	0	0
CRHR2	1395	broad.mit.edu	37	7	30695560	30695560	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:30695560G>A	ENST00000471646.1	-	9	1317	c.900C>T	c.(898-900)tcC>tcT	p.S300S	CRHR2_ENST00000348438.4_Silent_p.S327S|CRHR2_ENST00000341843.4_Silent_p.S286S|CRHR2_ENST00000506074.2_Silent_p.S300S	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	300					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GGATTGTCTCGGATGTGGTGG	0.562000													79	91					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179576846	179576846	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:179576846G>A	ENST00000589042.1	-	96	27935	c.27711C>T	c.(27709-27711)tcC>tcT	p.S9237S	TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Silent_p.S7993S|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Silent_p.S8920S|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8920	Ig-like 75.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTATACCAGGATACCCCAA	0.423000													23	58					0	0	0.002299	0	0
MARS	4141	broad.mit.edu	37	12	57906613	57906613	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:57906613G>A	ENST00000262027.5	+	15	1967	c.1833G>A	c.(1831-1833)ggG>ggA	p.G611G	MARS_ENST00000315473.5_Silent_p.G377G	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	611					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	AGGACACGGGGATCCCTGCTG	0.547000													40	118					0	0	0.006999	0	0
RP1	6101	broad.mit.edu	37	8	55538757	55538757	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:55538757G>A	ENST00000220676.1	+	4	2463	c.2315G>A	c.(2314-2316)gGa>gAa	p.G772E		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	772					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGGTTCAAGGACTTTTAACC	0.294000													19	43					0	0	0.007413	0	0
CSMD2	114784	broad.mit.edu	37	1	34285417	34285417	+	Silent	SNP	G	G	A	rs146766790		TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:34285417G>A	ENST00000373381.4	-	9	1397	c.1221C>T	c.(1219-1221)ttC>ttT	p.F407F		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	367	CUB 3.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CGTTGCAGGTGAACTGGACGC	0.592000													13	33					0	0	0.002450	0	0
CLPB	81570	broad.mit.edu	37	11	72145245	72145245	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:72145245G>A	ENST00000294053.3	-	1	447	c.274C>T	c.(274-276)Cct>Tct	p.P92S	CLPB_ENST00000437826.2_Missense_Mutation_p.S11F|CLPB_ENST00000538039.1_Missense_Mutation_p.P92S|CLPB_ENST00000340729.5_Missense_Mutation_p.P92S|CLPB_ENST00000543042.1_5'UTR|CLPB_ENST00000445069.2_Intron	NM_001258394.1|NM_030813.4	NP_001245323.1|NP_110440.1	Q9H078	CLPB_HUMAN	ClpB caseinolytic peptidase B homolog (E. coli)	92					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	19						TCGGGACCAGGAAGGCGTCCC	0.687000											OREG0021194	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	90	200					0	0	0.003610	0	0
EDN3	1908	broad.mit.edu	37	20	57896107	57896107	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr20:57896107G>A	ENST00000311585.7	+	3	771	c.401G>A	c.(400-402)gGa>gAa	p.G134E	EDN3_ENST00000371028.2_Missense_Mutation_p.G134E|EDN3_ENST00000337938.2_Missense_Mutation_p.G134E|EDN3_ENST00000371025.3_Missense_Mutation_p.G134E|EDN3_ENST00000395654.3_Missense_Mutation_p.G134E	NM_207032.1	NP_996915.1	P14138	EDN3_HUMAN	endothelin 3	134					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	19	all_lung(29;0.0115)					AACTACAGAGGAAGCTTCCGG	0.602000													20	54					0	0	0.008871	0	0
NID2	22795	broad.mit.edu	37	14	52526933	52526933	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:52526933C>T	ENST00000216286.5	-	3	675	c.676G>A	c.(676-678)Ggc>Agc	p.G226S	NID2_ENST00000541773.1_Missense_Mutation_p.G173S	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	226	NIDO.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CGGCAGAAGCCCACCCGAGCT	0.502000													12	43					0	0	0.001368	0	0
MUC16	94025	broad.mit.edu	37	19	9085586	9085586	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:9085586G>A	ENST00000397910.4	-	1	6432	c.6229C>T	c.(6229-6231)Cat>Tat	p.H2077Y		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2077	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACCCCAGAATGGCCTGAGGAC	0.468000													60	119					0	0	0.003610	0	0
KIF21B	23046	broad.mit.edu	37	1	200960261	200960261	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:200960261C>T	ENST00000332129.2	-	18	2787	c.2471G>A	c.(2470-2472)cGc>cAc	p.R824H	KIF21B_ENST00000360529.5_Missense_Mutation_p.R824H|KIF21B_ENST00000422435.2_Missense_Mutation_p.R824H|KIF21B_ENST00000461742.2_Missense_Mutation_p.R824H	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	824					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						CTTGGCCAGGCGCCTCAGTGC	0.657000													12	49					0	0	0.000978	0	0
NIPAL2	79815	broad.mit.edu	37	8	99208211	99208211	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:99208211G>A	ENST00000341166.3	-	9	1158	c.903C>T	c.(901-903)ttC>ttT	p.F301F	NIPAL2_ENST00000430223.2_Silent_p.F301F|NIPAL2_ENST00000520545.1_5'UTR	NM_024759.1	NP_079035.1	Q9H841	NPAL2_HUMAN	NIPA-like domain containing 2	301						integral to membrane				cervix(3)|kidney(1)|large_intestine(2)|lung(5)|stomach(1)	12						GAGCACCAAGGAATTCCTGAT	0.284000													8	48					0	0	0.004482	0	0
FLG	2312	broad.mit.edu	37	1	152282095	152282095	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:152282095C>T	ENST00000368799.1	-	3	5302	c.5267G>A	c.(5266-5268)gGg>gAg	p.G1756E	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1756	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGACCTTTCCCCTGACTGGCC	0.597000									Ichthyosis				191	188					0	0	0.003610	0	0
THBS2	7058	broad.mit.edu	37	6	169628377	169628377	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr6:169628377C>T	ENST00000366787.3	-	16	2509		c.e16-1		XXyac-YX65C7_A.2_ENST00000444188.1_RNA	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2						cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GGCAGTTGTCCTGGAAAACCA	0.488000													8	22					0	0	0.004482	0	0
APOB	338	broad.mit.edu	37	2	21230262	21230262	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:21230262C>T	ENST00000233242.1	-	26	9605	c.9478G>A	c.(9478-9480)Gaa>Aaa	p.E3160K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3160					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCAAGAATTCCTTCAAGCCT	0.358000													135	405					0	0	0.003610	0	0
MED23	9439	broad.mit.edu	37	6	131948547	131948547	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr6:131948547C>T	ENST00000403834.3	-	3	321	c.148G>A	c.(148-150)Ggt>Agt	p.G50S	MED23_ENST00000368058.1_Missense_Mutation_p.G50S|MED23_ENST00000368053.4_Missense_Mutation_p.G50S|MED23_ENST00000354577.4_Missense_Mutation_p.G50S|MED23_ENST00000368068.3_Missense_Mutation_p.G50S|MED23_ENST00000368060.3_Missense_Mutation_p.G50S|MED23_ENST00000540546.1_Missense_Mutation_p.G50S|MED23_ENST00000539158.1_Missense_Mutation_p.G50S			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	50					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		TGAGAAAGACCACCCCAAAAC	0.318000													32	56					0	0	0.004878	0	0
OR7C2	26658	broad.mit.edu	37	19	15053193	15053193	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:15053193G>A	ENST00000248072.3	+	1	893	c.893G>A	c.(892-894)gGg>gAg	p.G298E		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					GACATGAAGGGGTCACTGGGG	0.542000													18	71					0	0	0.004990	0	0
TET1	80312	broad.mit.edu	37	10	70332292	70332292	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr10:70332292C>T	ENST00000373644.4	+	2	406	c.197C>T	c.(196-198)cCa>cTa	p.P66L		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	66					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						GAACCTAAACCACCCGTGCCA	0.428000													33	36					0	0	0.003271	0	0
TACC1	6867	broad.mit.edu	37	8	38699874	38699874	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:38699874C>T	ENST00000379931.3	+	11	2445	c.2066C>T	c.(2065-2067)gCc>gTc	p.A689V	TACC1_ENST00000520973.1_Missense_Mutation_p.A453V|TACC1_ENST00000330691.6_Missense_Mutation_p.A251V|TACC1_ENST00000443286.2_Missense_Mutation_p.A664V|TACC1_ENST00000348567.4_Missense_Mutation_p.A239V|TACC1_ENST00000520615.1_Missense_Mutation_p.A482V|TACC1_ENST00000518415.1_Missense_Mutation_p.A603V|TACC1_ENST00000520611.1_Missense_Mutation_p.A114V|TACC1_ENST00000317827.4_Missense_Mutation_p.A677V|TACC1_ENST00000276520.8_Missense_Mutation_p.A267V|TACC1_ENST00000519416.1_Missense_Mutation_p.A481V			O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing protein 1	677					cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			breast(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(3)	17		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			AAGGAACAGGCCCTGGCTGAC	0.458000													25	142					0	0	0.002780	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				32	52					0	0	0.003271	0	0
C17orf74	201243	broad.mit.edu	37	17	7329686	7329686	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:7329686C>T	ENST00000333870.3	+	3	450	c.376C>T	c.(376-378)Cgc>Tgc	p.R126C	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000574034.1_Intron	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	126	Arg-rich.					integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				CTGTGTTcgtcgccgccgccg	0.612000													27	63					0	0	0.006320	0	0
MAD2L2	10459	broad.mit.edu	37	1	11736105	11736105	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:11736105G>A	ENST00000235310.3	-	8	1353	c.425C>T	c.(424-426)cCa>cTa	p.P142L	MAD2L2_ENST00000376667.3_Missense_Mutation_p.P142L|MAD2L2_ENST00000376692.4_Missense_Mutation_p.P142L|MAD2L2_ENST00000376669.5_Missense_Mutation_p.P155L|MAD2L2_ENST00000376672.1_Missense_Mutation_p.P155L			Q9UI95	MD2L2_HUMAN	MAD2 mitotic arrest deficient-like 2 (yeast)	142	HORMA.|Mediates interaction with REV1 and REV3L and homodimerization.				cell division|DNA damage response, signal transduction resulting in transcription|double-strand break repair|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of mitotic anaphase-promoting complex activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription, DNA-dependent|regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleoplasm|spindle|zeta DNA polymerase complex	JUN kinase binding			kidney(1)|large_intestine(1)|lung(2)|ovary(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGACACACCTGGGGGGTTGTG	0.572000								DNA polymerases (catalytic subunits)					13	40					0	0	0.004007	0	0
IYD	389434	broad.mit.edu	37	6	150719294	150719294	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr6:150719294C>T	ENST00000344419.3	+	5	931	c.791C>T	c.(790-792)cCc>cTc	p.P264L	IYD_ENST00000229447.5_3'UTR	NM_203395.2	NP_981932.1	Q6PHW0	IYD1_HUMAN	iodotyrosine deiodinase	264					cellular nitrogen compound metabolic process|hormone biosynthetic process	integral to membrane|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	15		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;4.16e-12)		ATGCTGCTCCCCGTGGGGTAC	0.632000													24	30					0	0	0.003330	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431950	140431950	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:140431950G>A	ENST00000306549.3	+	1	972	c.895G>A	c.(895-897)Gga>Aga	p.G299R		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		299	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTCAAAATGGAGAAGTTCG	0.468000													21	54					0	0	0.008871	0	0
KRT26	353288	broad.mit.edu	37	17	38928356	38928356	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:38928356G>A	ENST00000335552.4	-	1	58	c.10C>T	c.(10-12)Cga>Tga	p.R4*		NM_181539.4	NP_853517.2	Q7Z3Y9	K1C26_HUMAN	keratin 26	4	Head.					intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(5)	16		Breast(137;0.00526)				CCAGAAAGTCGAAAAGACATG	0.557000													30	54					0	0	0.002096	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795398	142795398	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chrX:142795398C>T	ENST00000370498.1	-	2	1033	c.280G>A	c.(280-282)Gga>Aga	p.G94R		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	94										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TGTGAAGATCCTTCAGCTGAG	0.498000													144	115					0	0	0.003610	0	0
CLP1	10978	broad.mit.edu	37	11	57428556	57428556	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:57428556G>A	ENST00000533682.1	+	3	1651	c.926G>A	c.(925-927)cGa>cAa	p.R309Q	CLP1_ENST00000525602.1_Missense_Mutation_p.R309Q|CLP1_ENST00000302731.4_Missense_Mutation_p.R245Q|CLP1_ENST00000529430.1_Missense_Mutation_p.R320Q			Q92989	CLP1_HUMAN	cleavage and polyadenylation factor I subunit 1	309					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|stomach(1)	15						TATGGATTCCGAGGCTGTTTC	0.502000													34	134					0	0	0.002445	0	0
NUP160	23279	broad.mit.edu	37	11	47819553	47819553	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:47819553G>A	ENST00000378460.2	-	26	3206	c.3160C>T	c.(3160-3162)Ccc>Tcc	p.P1054S	NUP160_ENST00000530326.1_Missense_Mutation_p.P940S|NUP160_ENST00000528071.1_Missense_Mutation_p.P940S	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	1054					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						TTCACATAGGGAAACTCTACA	0.398000													21	43					0	0	0.002299	0	0
RBFOX1	54715	broad.mit.edu	37	16	7629799	7629799	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr16:7629799G>A	ENST00000340209.4	+	3	603	c.306G>A	c.(304-306)ccG>ccA	p.P102P	RBFOX1_ENST00000553186.1_Silent_p.P97P|RBFOX1_ENST00000550418.1_Silent_p.P97P|RBFOX1_ENST00000547372.1_Silent_p.P140P|RBFOX1_ENST00000535565.2_Intron|RBFOX1_ENST00000311745.5_Silent_p.P117P|RBFOX1_ENST00000552089.1_Silent_p.P132P|RBFOX1_ENST00000436368.2_Silent_p.P117P|RBFOX1_ENST00000422070.4_Silent_p.P140P|RBFOX1_ENST00000355637.4_Silent_p.P117P|RBFOX1_ENST00000547338.1_Silent_p.P97P			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	97					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						ACGCAGCACCGACGGATGGCC	0.522000													14	48					0	0	0.003163	0	0
MUC6	4588	broad.mit.edu	37	11	1025023	1025023	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:1025023G>A	ENST00000421673.2	-	24	3096	c.3046C>T	c.(3046-3048)Cgc>Tgc	p.R1016C		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1016	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TACCTGCTGCGCGTCTCGAAG	0.642000													13	16					0	0	0.001855	0	0
WDR24	84219	broad.mit.edu	37	16	737699	737699	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr16:737699C>T	ENST00000293883.4	-	2	1281	c.522G>A	c.(520-522)cgG>cgA	p.R174R	WDR24_ENST00000248142.6_Silent_p.R304R	NM_032259.2	NP_115635.1	Q96S15	WDR24_HUMAN	WD repeat domain 24	236										breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(3)	19		Hepatocellular(780;0.0218)				TGAAGTAGTCCCGGATACTGA	0.637000													10	21					0	0	0.006214	0	0
AHDC1	27245	broad.mit.edu	37	1	27875200	27875200	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:27875200G>A	ENST00000374011.2	-	6	4395	c.3427C>T	c.(3427-3429)Ctg>Ttg	p.L1143L	AHDC1_ENST00000482400.2_Intron|AHDC1_ENST00000247087.5_Silent_p.L1143L	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1143							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GAGATGTCCAGGATCACGTTG	0.572000													18	67					0	0	0.001523	0	0
VPS39	23339	broad.mit.edu	37	15	42483350	42483350	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr15:42483350G>A	ENST00000318006.5	-	4	382	c.220C>T	c.(220-222)Cag>Tag	p.Q74*	VPS39_ENST00000348544.4_Nonsense_Mutation_p.Q85*	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	85	CNH.				protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		ATCTTAAACTGGGAAACCACA	0.343000													26	47					0	0	0.008361	0	0
DZIP1L	199221	broad.mit.edu	37	3	137787113	137787113	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:137787113G>A	ENST00000327532.2	-	13	2074	c.1712C>T	c.(1711-1713)cCa>cTa	p.P571L		NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	571						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						ACGAGTTGGTGGGGGTGGCTC	0.667000													194	542					0	0	0.003610	0	0
COL7A1	1294	broad.mit.edu	37	3	48610351	48610351	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:48610351G>A	ENST00000328333.8	-	86	6882	c.6775C>T	c.(6775-6777)Cca>Tca	p.P2259S	COL7A1_ENST00000454817.1_Missense_Mutation_p.P2227S	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2259	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TCTCGACCTGGGGCTCCCGGC	0.637000													21	47					0	0	0.008871	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52891101	52891101	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:52891101G>A	ENST00000371544.3	-	29	5049	c.4787C>T	c.(4786-4788)tCg>tTg	p.S1596L	ZCCHC11_ENST00000257177.4_Missense_Mutation_p.S1597L	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	1596	Pro-rich.				miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						ATAAGGCCACGAAGCTGGGAC	0.488000													17	54					0	0	0.004007	0	0
FDPS	2224	broad.mit.edu	37	1	155290374	155290374	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:155290374C>T	ENST00000356657.6	+	11	1396	c.1234C>T	c.(1234-1236)Cgc>Tgc	p.R412C	FDPS_ENST00000447866.1_Missense_Mutation_p.R346C|RUSC1-AS1_ENST00000450199.1_RNA|RUSC1-AS1_ENST00000446880.1_RNA|FDPS_ENST00000368356.4_Missense_Mutation_p.R412C|RUSC1-AS1_ENST00000543656.1_RNA|RUSC1-AS1_ENST00000443642.1_RNA	NM_001135821.1	NP_001129293.1	P14324	FPPS_HUMAN	farnesyl diphosphate synthase	412					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	GGGGCTTGCGCGCAAAATCTA	0.498000													39	28					0	0	0.002222	0	0
OR5B21	219968	broad.mit.edu	37	11	58274946	58274946	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:58274946G>A	ENST00000360374.2	-	1	632	c.633C>T	c.(631-633)atC>atT	p.I211I		NM_001005218.1	NP_001005218.1	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B, member 21	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I211I(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AAGAAATAAGGATGACCAGGA	0.488000													9	30					0	0	0.006214	0	0
RAPGEF1	2889	broad.mit.edu	37	9	134471739	134471739	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr9:134471739G>A	ENST00000372195.1	-	14	2371	c.2128C>T	c.(2128-2130)Cgc>Tgc	p.R710C	RAPGEF1_ENST00000372189.3_Missense_Mutation_p.R693C|RAPGEF1_ENST00000372190.3_Missense_Mutation_p.R711C			Q13905	RPGF1_HUMAN	Rap guanine nucleotide exchange factor (GEF) 1	693	N-terminal Ras-GEF.				activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	39		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		GATCCTCCGCGGACGTCCGGC	0.547000													6	9					0	0	0.006214	0	0
KIF2B	84643	broad.mit.edu	37	17	51900577	51900577	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:51900577G>A	ENST00000268919.4	+	1	339	c.183G>A	c.(181-183)gtG>gtA	p.V61V		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	61					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TAGAGTGGGTGGAGAAAGCAG	0.557000													36	79					0	0	0.004289	0	0
NAGLU	4669	broad.mit.edu	37	17	40695514	40695514	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:40695514T>A	ENST00000225927.2	+	6	1591	c.1490T>A	c.(1489-1491)cTg>cAg	p.L497Q	RP11-400F19.8_ENST00000585572.1_RNA	NM_000263.3	NP_000254.2	P54802	ANAG_HUMAN	N-acetylglucosaminidase, alpha	497						lysosome	alpha-N-acetylglucosaminidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(1)|ovary(2)|skin(1)	12		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	TGGAGGCTACTGCTCCGGAGT	0.657000													3	13					0	0	0.000248	0	0
IFT172	26160	broad.mit.edu	37	2	27706224	27706224	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:27706224G>A	ENST00000260570.3	-	7	605	c.502C>T	c.(502-504)Ctc>Ttc	p.L168F	IFT172_ENST00000416524.2_Missense_Mutation_p.L147F|IFT172_ENST00000359466.6_Missense_Mutation_p.L168F	NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	168					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					TGACCAGAGAGAATTCCTTTC	0.418000													16	56					0	0	0.006122	0	0
IGSF10	285313	broad.mit.edu	37	3	151165605	151165605	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:151165605G>A	ENST00000282466.3	-	4	2163	c.2164C>T	c.(2164-2166)Cgg>Tgg	p.R722W		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	722					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTTAATTCCCGATAGTTGTGC	0.493000													17	51					0	0	0.004990	0	0
PMCH	5367	broad.mit.edu	37	12	102591416	102591416	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:102591416C>T	ENST00000329406.4	-	1	207	c.133G>A	c.(133-135)Ggg>Agg	p.G45R		NM_002674.2	NP_002665.2	P20382	MCH_HUMAN	pro-melanin-concentrating hormone	45					cell differentiation|neuropeptide signaling pathway|spermatogenesis|synaptic transmission		melanin-concentrating hormone activity			large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	6						AAGCCTTTCCCCAACCTGAAT	0.348000													11	35					0	0	0.008291	0	0
EXPH5	23086	broad.mit.edu	37	11	108382300	108382300	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:108382300C>T	ENST00000265843.4	-	6	4044	c.3934G>A	c.(3934-3936)Gaa>Aaa	p.E1312K	EXPH5_ENST00000443411.1_Missense_Mutation_p.E1124K|EXPH5_ENST00000525344.1_Missense_Mutation_p.E1305K|EXPH5_ENST00000428840.1_Missense_Mutation_p.E1236K	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1312					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TTTAGATTTTCACATGAAGGT	0.413000													20	37					0	0	0.001523	0	0
SLC10A7	84068	broad.mit.edu	37	4	147204418	147204418	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:147204418C>T	ENST00000432059.2	-	9	981		c.e9-1		SLC10A7_ENST00000335472.7_Splice_Site|SLC10A7_ENST00000394062.3_Splice_Site|SLC10A7_ENST00000264986.3_Splice_Site|SLC10A7_ENST00000507030.1_Splice_Site			Q0GE19	NTCP7_HUMAN	solute carrier family 10, member 7							integral to membrane	bile acid:sodium symporter activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(8)|skin(1)	16	all_hematologic(180;0.151)					CGAATTATTCCTAGGGGCAAA	0.343000													12	32					0	0	0.001368	0	0
EPHB2	2048	broad.mit.edu	37	1	23111292	23111292	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:23111292C>T	ENST00000400191.3	+	3	552	c.534C>T	c.(532-534)ttC>ttT	p.F178F	EPHB2_ENST00000374632.3_Silent_p.F178F|EPHB2_ENST00000374627.1_Silent_p.F172F|EPHB2_ENST00000374630.3_Silent_p.F178F|EPHB2_ENST00000544305.1_Silent_p.F178F	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	178					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		ACCTGGCCTTCCAGGACTATG	0.612000													7	28					0	0	0.001984	0	0
C16orf11	146325	broad.mit.edu	37	16	615119	615119	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr16:615119C>T	ENST00000409413.3	+	3	1807	c.1528C>T	c.(1528-1530)Caa>Taa	p.Q510*		NM_145270.2	NP_660313.1	P0CG20	CP011_HUMAN	chromosome 16 open reading frame 11	510										central_nervous_system(1)|endometrium(1)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	10						TGCAGCGCCCCAACCCTTCTC	0.721000													11	20					0	0	0.001855	0	0
VTI1A	143187	broad.mit.edu	37	10	114575103	114575103	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr10:114575103C>T	ENST00000393077.2	+	8	731	c.615C>T	c.(613-615)acC>acT	p.T205T		NM_145206.2	NP_660207.2	Q96AJ9	VTI1A_HUMAN	vesicle transport through interaction with t-SNAREs 1A	0					intracellular protein transport|retrograde transport, endosome to Golgi	SNARE complex	protein transporter activity|SNAP receptor activity		VTI1A/TCF7L2(8)	breast(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	6		Colorectal(252;0.0314)|Breast(234;0.183)		Epithelial(162;0.0126)|all cancers(201;0.0487)		TGGTCATCACCATCCTGATGG	0.438000			T	TCF7L2	colorectal								28	41					0	0	0.002445	0	0
COL7A1	1294	broad.mit.edu	37	3	48610350	48610350	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:48610350G>A	ENST00000328333.8	-	86	6883	c.6776C>T	c.(6775-6777)cCa>cTa	p.P2259L	COL7A1_ENST00000454817.1_Missense_Mutation_p.P2227L	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2259	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ATCTCGACCTGGGGCTCCCGG	0.632000													21	45					0	0	0.008871	0	0
CYBB	1536	broad.mit.edu	37	X	37641395	37641395	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chrX:37641395G>A	ENST00000378588.4	+	2	167	c.100G>A	c.(100-102)Gat>Aat	p.D34N	CYBB_ENST00000536160.1_5'UTR|TM4SF2_ENST00000465127.1_Intron|CYBB_ENST00000545017.1_Intron	NM_000397.3	NP_000388.2	P04839	CY24B_HUMAN	cytochrome b-245, beta polypeptide	34					electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|prostate(2)|skin(2)	32						CCGGGTTTATGATATTCCACC	0.403000													16	25					0	0	0.007413	0	0
NYAP2	57624	broad.mit.edu	37	2	226378250	226378250	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:226378250G>A	ENST00000272907.6	+	3	798	c.385G>A	c.(385-387)Gat>Aat	p.D129N	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	129																	GGGCACAGACGATGACAGCAG	0.572000													21	42					0	0	0.002299	0	0
NREP	9315	broad.mit.edu	37	5	111066669	111066669	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:111066669C>T	ENST00000379671.3	-	5	420	c.156G>A	c.(154-156)ctG>ctA	p.L52L	NREP_ENST00000447165.2_Silent_p.L52L|NREP_ENST00000450761.2_Silent_p.L52L|NREP_ENST00000507742.1_5'UTR|NREP_ENST00000509025.1_Intron|NREP_ENST00000455559.2_Silent_p.L52L|STARD4-AS1_ENST00000513221.1_RNA|NREP_ENST00000453526.2_Silent_p.L52L|NREP_ENST00000257435.7_Silent_p.L52L|NREP_ENST00000508870.1_Silent_p.L52L|STARD4-AS1_ENST00000500779.2_RNA|NREP_ENST00000446294.2_Silent_p.L52L|NREP_ENST00000515855.1_3'UTR|NREP_ENST00000509427.1_Silent_p.L52L|NREP_ENST00000419114.2_Silent_p.L52L|NREP_ENST00000395634.3_Silent_p.L96L|NREP_ENST00000509979.1_3'UTR	NM_001142478.1	NP_001135950.1	Q16612	NP311_HUMAN	neuronal regeneration related protein	52						cytoplasm											CACTGCTGCCCAGTGGAGTCA	0.488000													44	80					0	0	0.008740	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460402	107460402	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:107460402C>T	ENST00000409382.3	-	2	642	c.32G>A	c.(31-33)cGa>cAa	p.R11Q	ST6GAL2_ENST00000361686.4_Missense_Mutation_p.R11Q|ST6GAL2_ENST00000409087.3_Missense_Mutation_p.R11Q	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	11					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity	p.R11Q(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						GAAAAGCATTCGTTGTCTCCA	0.507000													20	49					0	0	0.007413	0	0
PPFIA4	8497	broad.mit.edu	37	1	203040846	203040846	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:203040846C>T	ENST00000367240.2	+	27	3815	c.3288C>T	c.(3286-3288)ttC>ttT	p.F1096F	PPFIA4_ENST00000599966.1_Silent_p.F602F|PPFIA4_ENST00000295706.4_Silent_p.F602F|PPFIA4_ENST00000447715.2_Silent_p.F1095F|PPFIA4_ENST00000272198.6_Silent_p.F611F|PPFIA4_ENST00000414050.2_Silent_p.F824F			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	611					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						AAAGAGAGTTCAATAACCTGT	0.498000													12	14					0	0	0.002450	0	0
NASP	4678	broad.mit.edu	37	1	46073706	46073706	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:46073706C>T	ENST00000350030.3	+	6	1210	c.1123C>T	c.(1123-1125)Cct>Tct	p.P375S	NASP_ENST00000372052.4_Intron|NASP_ENST00000351223.3_Intron|NASP_ENST00000537798.1_Missense_Mutation_p.P311S|NASP_ENST00000402363.3_Missense_Mutation_p.P377S	NM_002482.3	NP_002473.2	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein (histone-binding)	375	Glu-rich (acidic).				blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	17	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					TCCAGTTCTCCCTAAGGATGG	0.502000													48	149					0	0	0.003610	0	0
ABCA8	10351	broad.mit.edu	37	17	66925340	66925340	+	Silent	SNP	C	C	T	rs143207789	by1000genomes	TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:66925340C>T	ENST00000269080.2	-	8	1112	c.975G>A	c.(973-975)aaG>aaA	p.K325K	ABCA8_ENST00000586539.1_Silent_p.K325K|ABCA8_ENST00000430352.2_Silent_p.K325K	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	325						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.K325N(1)		breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GGAAAGATTTCTTTACCAAGA	0.418000													18	20					0	0	0.001882	0	0
SUV420H1	51111	broad.mit.edu	37	11	67947635	67947635	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:67947635G>A	ENST00000304363.4	-	4	694	c.341C>T	c.(340-342)tCa>tTa	p.S114L	SUV420H1_ENST00000405515.1_Missense_Mutation_p.S114L|SUV420H1_ENST00000402789.1_Missense_Mutation_p.S114L|SUV420H1_ENST00000402185.2_Intron|SUV420H1_ENST00000401547.2_Missense_Mutation_p.S114L	NM_017635.3	NP_060105.3	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						gtcagattttgaaaaatgcct	0.333000													5	8					0	0	0.001984	0	0
CHRM2	1129	broad.mit.edu	37	7	136700134	136700134	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:136700134G>A	ENST00000445907.2	+	3	1050	c.522G>A	c.(520-522)ggG>ggA	p.G174G	CHRM2_ENST00000397608.3_Silent_p.G174G|AC009264.1_ENST00000592183.1_RNA|CHRM2_ENST00000401861.1_Silent_p.G174G|AC009264.1_ENST00000586239.1_RNA|AC009264.1_ENST00000598184.1_RNA|AC009264.1_ENST00000597642.1_RNA|CHRM2_ENST00000320658.5_Silent_p.G174G|AC009264.1_ENST00000439694.1_RNA|AC009264.1_ENST00000593789.1_RNA|CHRM2_ENST00000453373.1_Silent_p.G174G|AC009264.1_ENST00000425981.2_RNA|CHRM2_ENST00000402486.3_Silent_p.G174G	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	174					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	TGGAGGATGGGGAGTGCTACA	0.488000													92	101					0	0	0.003610	0	0
ARID2	196528	broad.mit.edu	37	12	46244034	46244034	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:46244034C>T	ENST00000334344.6	+	15	2300	c.2128C>T	c.(2128-2130)Cct>Tct	p.P710S	ARID2_ENST00000444670.1_Missense_Mutation_p.P320S|ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Missense_Mutation_p.P561S	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	710					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		AGCTCCAATTCCTTGTGAAGT	0.438000			"""N, S, F"""		hepatocellular carcinoma								49	91					0	0	0.003610	0	0
MET	4233	broad.mit.edu	37	7	116411677	116411677	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:116411677C>T	ENST00000397752.3	+	13	3056	c.2856C>T	c.(2854-2856)ttC>ttT	p.F952F	MET_ENST00000318493.6_Silent_p.F970F	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	952					axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TTGGGTTTTTCCTGTGGCTGA	0.343000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				24	110					0	0	0.007291	0	0
C1orf27	54953	broad.mit.edu	37	1	186375259	186375259	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:186375259C>T	ENST00000367470.3	+	11	1212	c.976C>T	c.(976-978)Ccc>Tcc	p.P326S	C1orf27_ENST00000419367.3_Missense_Mutation_p.P317S|C1orf27_ENST00000287859.6_Missense_Mutation_p.P349S|C1orf27_ENST00000432021.3_Missense_Mutation_p.P326S	NM_001164245.1	NP_001157717.1	Q5SWX8	ODR4_HUMAN	chromosome 1 open reading frame 27	349						integral to membrane	oxidoreductase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)	9						AGTCTTTGTTCCCCTTCCTGG	0.373000													74	61					0	0	0.003610	0	0
CNTN1	1272	broad.mit.edu	37	12	41410719	41410719	+	Splice_Site	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:41410719G>A	ENST00000551295.2	+	19	2536		c.e19+1		CNTN1_ENST00000348761.2_Splice_Site|CNTN1_ENST00000347616.1_Splice_Site|CNTN1_ENST00000550305.1_Splice_Site	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1						axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GCACAAGACGGTAGGTGAAAG	0.423000													7	33					0	0	0.001984	0	0
SNCAIP	9627	broad.mit.edu	37	5	121786472	121786472	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:121786472G>A	ENST00000261367.7	+	12	3499	c.2071G>A	c.(2071-2073)Gat>Aat	p.D691N	SNCAIP_ENST00000261368.8_Missense_Mutation_p.D644N|CTC-210G5.1_ENST00000506053.1_RNA|CTC-210G5.1_ENST00000509993.1_RNA|SNCAIP_ENST00000503116.2_3'UTR|SNCAIP_ENST00000379538.3_Missense_Mutation_p.D278N|SNCAIP_ENST00000504884.2_3'UTR|SNCAIP_ENST00000379536.2_Missense_Mutation_p.D584N|CTC-210G5.1_ENST00000510972.1_RNA|SNCAIP_ENST00000414317.2_Missense_Mutation_p.D246N|SNCAIP_ENST00000542191.1_Missense_Mutation_p.D202N|SNCAIP_ENST00000379533.2_Missense_Mutation_p.D691N|CTC-210G5.1_ENST00000503529.1_RNA|CTC-210G5.1_ENST00000505546.1_RNA			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	644					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GGAATTCCAGGATGCTCAGGC	0.438000													14	35					0	0	0.003163	0	0
MRC2	9902	broad.mit.edu	37	17	60769493	60769493	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:60769493C>T	ENST00000303375.5	+	29	4615	c.4213C>T	c.(4213-4215)Cca>Tca	p.P1405S	MRC2_ENST00000446119.2_Missense_Mutation_p.P271S	NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	1405					endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						CAGCTTCTCCCCATCAGGTGA	0.547000													20	46					0	0	0.002780	0	0
DEF8	54849	broad.mit.edu	37	16	90030674	90030674	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr16:90030674G>A	ENST00000563594.1	+	11	2096	c.1099G>A	c.(1099-1101)Gag>Aag	p.E367K	DEF8_ENST00000268676.7_Missense_Mutation_p.E428K|DEF8_ENST00000570182.1_Missense_Mutation_p.E357K|DEF8_ENST00000569453.1_Missense_Mutation_p.E367K|DEF8_ENST00000567874.1_Missense_Mutation_p.E307K|DEF8_ENST00000563795.1_Missense_Mutation_p.E350K	NM_001242818.1|NM_001242819.1	NP_001229747.1|NP_001229748.1	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 homolog (mouse)	428					intracellular signal transduction		zinc ion binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		CTCGCTCACCGAGATCCACAC	0.642000													10	9					0	0	0.006214	0	0
NREP	9315	broad.mit.edu	37	5	111066668	111066668	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:111066668C>T	ENST00000379671.3	-	5	421	c.157G>A	c.(157-159)Ggc>Agc	p.G53S	NREP_ENST00000447165.2_Missense_Mutation_p.G53S|NREP_ENST00000450761.2_Missense_Mutation_p.G53S|NREP_ENST00000507742.1_5'UTR|NREP_ENST00000509025.1_Intron|NREP_ENST00000455559.2_Missense_Mutation_p.G53S|STARD4-AS1_ENST00000513221.1_RNA|NREP_ENST00000453526.2_Missense_Mutation_p.G53S|NREP_ENST00000257435.7_Missense_Mutation_p.G53S|NREP_ENST00000508870.1_Missense_Mutation_p.G53S|STARD4-AS1_ENST00000500779.2_RNA|NREP_ENST00000446294.2_Missense_Mutation_p.G53S|NREP_ENST00000515855.1_3'UTR|NREP_ENST00000509427.1_Missense_Mutation_p.G53S|NREP_ENST00000419114.2_Missense_Mutation_p.G53S|NREP_ENST00000395634.3_Missense_Mutation_p.G97S|NREP_ENST00000509979.1_3'UTR	NM_001142478.1	NP_001135950.1	Q16612	NP311_HUMAN	neuronal regeneration related protein	53						cytoplasm											TCACTGCTGCCCAGTGGAGTC	0.488000													44	80					0	0	0.008740	0	0
OBSCN	84033	broad.mit.edu	37	1	228467077	228467077	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:228467077C>T	ENST00000570156.2	+	32	8689	c.8615C>T	c.(8614-8616)tCc>tTc	p.S2872F	OBSCN_ENST00000422127.1_Missense_Mutation_p.S2443F|OBSCN_ENST00000284548.11_Missense_Mutation_p.S2443F|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000359599.6_Missense_Mutation_p.S1290F	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1872	Ig-like 28.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CGGACCTGCTCCACCATGACC	0.697000													27	101					0	0	0.008361	0	0
MOSPD3	64598	broad.mit.edu	37	7	100211217	100211217	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:100211217C>T	ENST00000393950.2	+	3	681	c.399C>T	c.(397-399)tcC>tcT	p.S133S	MOSPD3_ENST00000424091.2_Silent_p.S123S|MOSPD3_ENST00000379527.2_Silent_p.S133S|MOSPD3_ENST00000223054.4_Silent_p.S133S	NM_023948.4	NP_076438.1	O75425	MSPD3_HUMAN	motile sperm domain containing 3	133	MSP.					integral to membrane	structural molecule activity			breast(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	16	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					ACATTACCTCCATTCTGAGAG	0.632000													13	81					0	0	0.002450	0	0
CAPN6	827	broad.mit.edu	37	X	110494267	110494267	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chrX:110494267G>A	ENST00000324068.1	-	8	1203	c.1036C>T	c.(1036-1038)Cct>Tct	p.P346S	CAPN6_ENST00000541758.1_Missense_Mutation_p.P91S	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	346	Domain III.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						CCAAAAATAGGGTTGTTCACA	0.483000													132	122					0	0	0.003610	0	0
SELE	6401	broad.mit.edu	37	1	169698340	169698340	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:169698340G>A	ENST00000333360.7	-	7	1216	c.1077C>T	c.(1075-1077)atC>atT	p.I359I	SELE_ENST00000367774.1_Silent_p.I359I|SELE_ENST00000367775.1_Silent_p.I297I|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367780.4_Silent_p.I297I|SELE_ENST00000367777.1_Silent_p.I359I|SELE_ENST00000367779.4_Silent_p.I359I|SELE_ENST00000367782.4_Silent_p.I359I|SELE_ENST00000367781.4_Silent_p.I359I|SELE_ENST00000367776.1_Silent_p.I359I	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	359	Sushi 3.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					CACAAACTGGGATTTGCTGTG	0.438000													46	41					0	0	0.003610	0	0
PHOX2B	8929	broad.mit.edu	37	4	41747907	41747907	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:41747907C>T	ENST00000226382.2	-	3	1221	c.862G>A	c.(862-864)Ggg>Agg	p.G288R		NM_003924.3	NP_003915.2	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	288					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	30						AAGGGACCCCCAAGCGAATCC	0.667000			"""Mis, F"""		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				14	42					0	0	0.004990	0	0
MUC16	94025	broad.mit.edu	37	19	9046738	9046738	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:9046738C>T	ENST00000397910.4	-	5	35096	c.34893G>A	c.(34891-34893)gtG>gtA	p.V11631V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11633	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.V11631V(1)|p.V7264V(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCTGTGAGGTCACTACCCCTG	0.527000													39	75					0	0	0.005524	0	0
FAM171B	165215	broad.mit.edu	37	2	187626884	187626884	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:187626884C>T	ENST00000304698.5	+	8	2018	c.1815C>T	c.(1813-1815)atC>atT	p.I605I		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	605						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						AAGAGGATATCATACTTGAAG	0.478000													32	64					0	0	0.001786	0	0
GPR161	23432	broad.mit.edu	37	1	168066237	168066237	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:168066237A>G	ENST00000367838.1	-	5	921	c.608T>C	c.(607-609)gTc>gCc	p.V203A	GPR161_ENST00000367835.1_Missense_Mutation_p.V203A|GPR161_ENST00000546300.1_Missense_Mutation_p.V89A|GPR161_ENST00000361697.2_Missense_Mutation_p.V203A|GPR161_ENST00000537209.1_Missense_Mutation_p.V223A|GPR161_ENST00000539777.1_Missense_Mutation_p.V125A|GPR161_ENST00000367836.1_Missense_Mutation_p.V71A|GPR161_ENST00000271357.5_Missense_Mutation_p.V203A	NM_001267611.1|NM_153832.2	NP_001254540.1|NP_722561.1	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161	203					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					CACCAGCATGACCAGAAAGGG	0.587000													3	54					0	0	0.004672	0	0
NUPL2	11097	broad.mit.edu	37	7	23236306	23236306	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:23236306C>T	ENST00000258742.5	+	5	789	c.530C>T	c.(529-531)tCt>tTt	p.S177F		NM_007342.2	NP_031368.1	O15504	NUPL2_HUMAN	nucleoporin like 2	177					carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CAGCTAAATTCTGTCCAACGT	0.308000													12	49					0	0	0.004007	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431951	140431951	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:140431951G>A	ENST00000306549.3	+	1	973	c.896G>A	c.(895-897)gGa>gAa	p.G299E		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		299	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTCAAAATGGAGAAGTTCGA	0.468000													21	53					0	0	0.008871	0	0
GSDMC	56169	broad.mit.edu	37	8	130789639	130789639	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:130789639G>A	ENST00000276708.4	-	2	1076	c.195C>T	c.(193-195)atC>atT	p.I65I		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	65						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						TTGGCTCCAGGATGTCATTGA	0.433000													12	46					0	0	0.000978	0	0
MOSPD3	64598	broad.mit.edu	37	7	100211216	100211216	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:100211216C>T	ENST00000393950.2	+	3	680	c.398C>T	c.(397-399)tCc>tTc	p.S133F	MOSPD3_ENST00000424091.2_Missense_Mutation_p.S123F|MOSPD3_ENST00000379527.2_Missense_Mutation_p.S133F|MOSPD3_ENST00000223054.4_Missense_Mutation_p.S133F	NM_023948.4	NP_076438.1	O75425	MSPD3_HUMAN	motile sperm domain containing 3	133	MSP.					integral to membrane	structural molecule activity			breast(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	16	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GACATTACCTCCATTCTGAGA	0.632000													14	83					0	0	0.002450	0	0
LRP1B	53353	broad.mit.edu	37	2	141777614	141777614	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:141777614G>A	ENST00000389484.3	-	12	2818	c.1847C>T	c.(1846-1848)aCc>aTc	p.T616I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	616					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCCATCATTGGTCCAGTAAAG	0.398000										TSP Lung(27;0.18)			22	84					0	0	0.003330	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367362	234367362	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:234367362G>A	ENST00000366618.3	+	3	628	c.483G>A	c.(481-483)agG>agA	p.R161R	SLC35F3_ENST00000366617.3_Silent_p.R92R	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	92					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TGACCTTCAGGAAGTTCGACG	0.602000													42	215					0	0	0.003610	0	0
OR4M1	441670	broad.mit.edu	37	14	20248933	20248933	+	Missense_Mutation	SNP	G	G	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:20248933G>T	ENST00000315957.4	+	1	533	c.452G>T	c.(451-453)gGg>gTg	p.G151V		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCCTGGATGGGGGGCTTCATT	0.498000													66	374					1.25706e-45	1.44355e-45	0.003610	1	0
CYTIP	9595	broad.mit.edu	37	2	158272504	158272504	+	Missense_Mutation	SNP	C	C	T	rs140145189	byFrequency	TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:158272504C>T	ENST00000264192.3	-	8	886	c.765G>A	c.(763-765)atG>atA	p.M255I	CYTIP_ENST00000540637.1_Missense_Mutation_p.M149I	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	255	Ser-rich.				regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						CTTCACTGTCCATCGTCATGG	0.567000													17	51					0	0	0.007413	0	0
WIPI1	55062	broad.mit.edu	37	17	66440649	66440649	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:66440649G>A	ENST00000262139.5	-	4	414	c.415C>T	c.(415-417)Cct>Tct	p.P139S	WIPI1_ENST00000589459.1_5'UTR|WIPI1_ENST00000546360.1_Missense_Mutation_p.P57S	NM_017983.5	NP_060453.3	Q5MNZ9	WIPI1_HUMAN	WD repeat domain, phosphoinositide interacting 1	139					macroautophagy|vesicle targeting, trans-Golgi to endosome	autophagic vacuole membrane|clathrin-coated vesicle|cytosol|endosome membrane|PAS complex|pre-autophagosomal structure membrane|trans-Golgi network	androgen receptor binding|estrogen receptor binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	18						GGGTTTGCAGGAATATCCAGG	0.418000													26	47					0	0	0.007291	0	0
SDS	10993	broad.mit.edu	37	12	113836602	113836602	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:113836602G>A	ENST00000257549.4	-	4	365	c.243C>T	c.(241-243)gtC>gtT	p.V81V		NM_006843.2	NP_006834.2	P20132	SDHL_HUMAN	serine dehydratase	81					gluconeogenesis|L-serine catabolic process|pyruvate biosynthetic process	cytoplasm	L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|protein homodimerization activity|pyridoxal phosphate binding			large_intestine(2)|lung(6)|pancreas(1)|prostate(1)|urinary_tract(1)	11					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	TGGTGGCGGGGACGCCGAGTT	0.662000													8	14					0	0	0.003080	0	0
TTN	7273	broad.mit.edu	37	2	179484829	179484829	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:179484829C>T	ENST00000589042.1	-	249	46539	c.46315G>A	c.(46315-46317)Gaa>Aaa	p.E15439K	TTN_ENST00000359218.5_Missense_Mutation_p.E6499K|TTN_ENST00000342992.6_Missense_Mutation_p.E12871K|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E6566K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000604956.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E13798K|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E6374K|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13798	Fibronectin type-III 12.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATCTTTTTCAAATTTGTAT	0.363000													28	63					0	0	0.006320	0	0
PRSS35	167681	broad.mit.edu	37	6	84234103	84234103	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr6:84234103G>A	ENST00000536636.1	+	3	1288	c.943G>A	c.(943-945)Gat>Aat	p.D315N	PRSS35_ENST00000369700.3_Missense_Mutation_p.D315N	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	315	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		ATTTGATAACGATAGGGCTGA	0.473000													18	42					0	0	0.006122	0	0
NKAIN3	286183	broad.mit.edu	37	8	63659614	63659614	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:63659614G>A	ENST00000523211.1	+	4	529	c.397G>A	c.(397-399)Gtc>Atc	p.V133I	NKAIN3_ENST00000519049.1_3'UTR|NKAIN3_ENST00000328472.5_Missense_Mutation_p.V133I	NM_173688.2	NP_775959.1	Q8N8D7	NKAI3_HUMAN	Na+/K+ transporting ATPase interacting 3	133						integral to membrane|plasma membrane				kidney(3)|large_intestine(2)|lung(8)	13	Breast(64;0.127)	Lung NSC(129;0.187)				TTACACGTACGTCTCTGTCAC	0.498000													15	64					0	0	0.004007	0	0
FAT4	79633	broad.mit.edu	37	4	126372503	126372503	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:126372503C>T	ENST00000394329.3	+	9	10345	c.10332C>T	c.(10330-10332)atC>atT	p.I3444I	FAT4_ENST00000335110.5_Silent_p.I1742I	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3444	Cadherin 33.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CTTACTTCATCGGATCAGGGA	0.463000													39	83					0	0	0.006999	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54936379	54936379	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr12:54936379C>T	ENST00000293373.6	+	31	3373	c.3294C>T	c.(3292-3294)ttC>ttT	p.F1098F	NCKAP1L_ENST00000545638.2_Silent_p.F1048F	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	1098					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						AGTCATCCTTCCTGACCCTGG	0.527000													38	123					0	0	0.002222	0	0
IGHG4	3503	broad.mit.edu	37	14	106092128	106092128	+	RNA	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:106092128G>A	ENST00000390543.2	-	0	275																											TGTCCACCTTGGTGTTGCTGG	0.627000													52	191					0	0	0.003610	0	0
SNRNP48	154007	broad.mit.edu	37	6	7601663	7601663	+	Silent	SNP	C	C	T	rs148291598	byFrequency	TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr6:7601663C>T	ENST00000342415.5	+	5	560	c.501C>T	c.(499-501)ttC>ttT	p.F167F		NM_152551.3	NP_689764.3	Q6IEG0	SNR48_HUMAN	small nuclear ribonucleoprotein 48kDa (U11/U12)	167					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding			kidney(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	10						TCTATGATTTCGTAGTTGAGG	0.378000													34	64					0	0	0.003271	0	0
MYH15	22989	broad.mit.edu	37	3	108183656	108183656	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:108183656C>T	ENST00000273353.3	-	16	1676	c.1620G>A	c.(1618-1620)atG>atA	p.M540I		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	540	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity	p.M540I(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						AAAGGATGCCCATTGGCTGTT	0.423000													25	52					0	0	0.003330	0	0
MIR519E	574463	broad.mit.edu	37	19	54183226	54183226	+	RNA	SNP	T	T	C			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:54183226T>C	ENST00000385075.1	+	0	33					NR_030185.1																						AGGGAGCACTTTCTGTTTGAA	0.398000													12	26					0	0	0.001855	0	0
SEMA7A	8482	broad.mit.edu	37	15	74706984	74706984	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr15:74706984G>A	ENST00000261918.4	-	10	1746	c.1198C>T	c.(1198-1200)Cca>Tca	p.P400S	SEMA7A_ENST00000542748.1_Missense_Mutation_p.P235S|SEMA7A_ENST00000543145.2_Missense_Mutation_p.P386S	NM_003612.3	NP_003603.1	O75326	SEM7A_HUMAN	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	400	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	30						TGGAACAATGGCGTCTTCAGA	0.587000													37	100					0	0	0.003755	0	0
GLRA3	8001	broad.mit.edu	37	4	175577931	175577931	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:175577931G>A	ENST00000274093.3	-	9	1581	c.1079C>T	c.(1078-1080)gCt>gTt	p.A360V	GLRA3_ENST00000340217.5_Intron	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	360					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	CAGTGCAAAAGCTTCTGTCTG	0.343000													12	11					0	0	0.004007	0	0
TLE4	7091	broad.mit.edu	37	9	82319812	82319812	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr9:82319812C>T	ENST00000376520.4	+	9	1552	c.724C>T	c.(724-726)Cgt>Tgt	p.R242C	TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000376537.4_Missense_Mutation_p.R242C|TLE4_ENST00000376544.3_Missense_Mutation_p.R242C|TLE4_ENST00000376552.2_Missense_Mutation_p.R242C|TLE4_ENST00000265284.6_Missense_Mutation_p.R217C			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						AATTGCAGCTCGTTATGTAAG	0.463000													36	43					0	0	0.004289	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502954	140502954	+	Silent	SNP	C	C	T	rs148427211		TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:140502954C>T	ENST00000194152.1	+	1	1374	c.1374C>T	c.(1372-1374)ttC>ttT	p.F458F		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		458	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding	p.F458F(1)		autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.627000													36	94					0	0	0.003610	0	0
SLC35C2	51006	broad.mit.edu	37	20	44980727	44980727	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr20:44980727G>A	ENST00000372227.1	-	8	1340	c.800C>T	c.(799-801)aCc>aTc	p.T267I	SLC35C2_ENST00000243896.2_Missense_Mutation_p.T267I|SLC35C2_ENST00000372230.5_Missense_Mutation_p.T267I|SLC35C2_ENST00000493599.1_5'UTR|SLC35C2_ENST00000543605.1_Missense_Mutation_p.T296I|SLC35C2_ENST00000372229.1_Missense_Mutation_p.T134I|SLC35C2_ENST00000317734.8_Missense_Mutation_p.T246I			Q9NQQ7	S35C2_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C2	267					transport	integral to membrane				cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	16		Myeloproliferative disorder(115;0.0122)				GAGGCTGGAGGTTCTGGAGAC	0.582000													13	49					0	0	0.001368	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319128	21319128	+	Silent	SNP	C	C	T	rs146165782	byFrequency	TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:21319128C>T	ENST00000583088.1	+	3	1369	c.474C>T	c.(472-474)gcC>gcT	p.A158A	KCNJ12_ENST00000331718.5_Silent_p.A158A	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		GCCCGGTGGCCGTCTTCATGG	0.622000										Prostate(3;0.18)			8	48					0	0	0.003080	0	0
SUPT16H	11198	broad.mit.edu	37	14	21821654	21821654	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:21821654G>A	ENST00000216297.2	-	25	3329	c.2991C>T	c.(2989-2991)gcC>gcT	p.A997A		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	997	Glu-rich (acidic).				DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		AACCTTTTCGGGCTTCTTCCT	0.343000													33	75					0	0	0.003755	0	0
SERPINA12	145264	broad.mit.edu	37	14	94962730	94962730	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:94962730C>T	ENST00000341228.2	-	4	1680	c.885G>A	c.(883-885)tgG>tgA	p.W295*	SERPINA12_ENST00000556881.1_Nonsense_Mutation_p.W295*	NM_173850.2	NP_776249.1	Q8IW75	SPA12_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	295					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33				COAD - Colon adenocarcinoma(157;0.235)		GTAATGTTTTCCATCTGGAGA	0.478000													34	77					0	0	0.002445	0	0
FGB	2244	broad.mit.edu	37	4	155486961	155486961	+	Splice_Site	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:155486961G>A	ENST00000302068.4	+	2	179	c.114_splice	c.e2-1	p.G39_splice	FGB_ENST00000509493.1_Intron|FGB_ENST00000502545.1_3'UTR	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	39			Missing (in New York-1).		platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TCCTTGTAGGGTTTCTTCAGT	0.473000													9	43					0	0	0.008291	0	0
COL4A1	1282	broad.mit.edu	37	13	110847436	110847436	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr13:110847436G>A	ENST00000375820.4	-	22	1436	c.1315C>T	c.(1315-1317)Cca>Tca	p.P439S	COL4A1_ENST00000543140.1_Missense_Mutation_p.P439S	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	439	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TGGTCACCTGGAGGTCCGGGC	0.428000													21	22					0	0	0.002299	0	0
CPSF1	29894	broad.mit.edu	37	8	145625048	145625048	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:145625048G>A	ENST00000349769.3	-	12	1266	c.1172C>T	c.(1171-1173)tCc>tTc	p.S391F		NM_013291.2	NP_037423.2	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1, 160kDa	391					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			GAGGAGGAGGGAATTGCCCAG	0.652000													8	17					0	0	0.006214	0	0
OR4B1	119765	broad.mit.edu	37	11	48238934	48238934	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:48238934C>T	ENST00000309562.2	+	1	591	c.573C>T	c.(571-573)ttC>ttT	p.F191F		NM_001005470.1	NP_001005470.1	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B, member 1	191					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						CTGACACCTTCATGGAGGGGG	0.453000													24	94					0	0	0.003330	0	0
LSM3	27258	broad.mit.edu	37	3	14239547	14239547	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:14239547G>A	ENST00000306024.3	+	4	743	c.240G>A	c.(238-240)cgG>cgA	p.R80R		NM_014463.2	NP_055278.1	P62310	LSM3_HUMAN	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	80					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	catalytic step 2 spliceosome|cytosol	protein binding|RNA binding	p.R80R(1)		central_nervous_system(1)|large_intestine(2)|ovary(1)	4						CAACGAAACGGAATATTCCAA	0.398000													15	51					0	0	0.003163	0	0
PARP8	79668	broad.mit.edu	37	5	50091235	50091235	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:50091235C>T	ENST00000281631.5	+	12	1570	c.1412C>T	c.(1411-1413)tCa>tTa	p.S471L	PARP8_ENST00000503750.2_Missense_Mutation_p.S471L|PARP8_ENST00000505697.2_Missense_Mutation_p.S471L|PARP8_ENST00000514067.2_Missense_Mutation_p.S471L|PARP8_ENST00000505554.1_Missense_Mutation_p.S450L|PARP8_ENST00000514342.2_Missense_Mutation_p.S224L|PARP8_ENST00000511363.2_3'UTR	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	471	Poly-Ser.					intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				TCTTCATCTTCATCTTCTCAG	0.398000													15	43					0	0	0.003163	0	0
FRG2B	441581	broad.mit.edu	37	10	135438846	135438846	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr10:135438846G>A	ENST00000443774.1	-	4	646	c.597C>T	c.(595-597)atC>atT	p.I199I	FRG2B_ENST00000425520.1_Silent_p.I198I			Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	198						nucleus				endometrium(2)|kidney(2)|lung(14)|ovary(1)|prostate(1)	20		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		GTGGAGAATGGATCTGCTGTG	0.562000													20	20					0	0	0.003330	0	0
TTN	7273	broad.mit.edu	37	2	179640923	179640923	+	Missense_Mutation	SNP	G	G	A	rs146496197	byFrequency	TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:179640923G>A	ENST00000589042.1	-	28	5892	c.5668C>T	c.(5668-5670)Cgc>Tgc	p.R1890C	TTN_ENST00000359218.5_Missense_Mutation_p.R1844C|TTN_ENST00000342992.6_Missense_Mutation_p.R1890C|TTN_ENST00000342175.6_Missense_Mutation_p.R1844C|TTN_ENST00000591111.1_Missense_Mutation_p.R1890C|TTN_ENST00000460472.2_Missense_Mutation_p.R1844C|TTN_ENST00000360870.5_Missense_Mutation_p.R1890C	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1605	Ig-like 9.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R1844C(3)|p.R1890C(2)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATCATAGCGAACTCTGAAC	0.498000													70	200					0	0	0.003610	0	0
FLG	2312	broad.mit.edu	37	1	152282094	152282094	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:152282094C>T	ENST00000368799.1	-	3	5303	c.5268G>A	c.(5266-5268)ggG>ggA	p.G1756G	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1756	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGACCTTTCCCCTGACTGGC	0.597000									Ichthyosis				192	183					0	0	0.003610	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													3	42					0	0	0.004672	0	0
MYO18B	84700	broad.mit.edu	37	22	26164488	26164488	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr22:26164488C>T	ENST00000335473.7	+	4	855	c.605C>T	c.(604-606)tCc>tTc	p.S202F	MYO18B_ENST00000407587.2_Missense_Mutation_p.S202F|MYO18B_ENST00000536101.1_Missense_Mutation_p.S202F	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	202						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CCTTGTGGCTCCCAGGCCAGC	0.597000													5	8					0	0	0.001984	0	0
XIRP2	129446	broad.mit.edu	37	2	168114919	168114919	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:168114919G>A	ENST00000409728.1	+	11	2051	c.1962G>A	c.(1960-1962)atG>atA	p.M654I	XIRP2_ENST00000409195.1_3'UTR|XIRP2_ENST00000295237.9_3'UTR|XIRP2_ENST00000409043.1_Missense_Mutation_p.M621I|XIRP2_ENST00000409756.2_Missense_Mutation_p.M621I|XIRP2_ENST00000409605.1_Missense_Mutation_p.M399I|XIRP2_ENST00000409273.1_3'UTR|XIRP2_ENST00000420519.1_Missense_Mutation_p.M654I	NM_001199143.1	NP_001186072.1	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2732					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TCAAAGAAATGAAAATGCCTg	0.383000													22	36					0	0	0.001523	0	0
DZIP1L	199221	broad.mit.edu	37	3	137787114	137787114	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:137787114G>A	ENST00000327532.2	-	13	2073	c.1711C>T	c.(1711-1713)Cca>Tca	p.P571S		NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	571						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						CGAGTTGGTGGGGGTGGCTCT	0.667000													195	540					0	0	0.003610	0	0
SLC9C2	284525	broad.mit.edu	37	1	173517593	173517593	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:173517593C>T	ENST00000367714.3	-	12	1818	c.1396G>A	c.(1396-1398)Gaa>Aaa	p.E466K	SLC9C2_ENST00000536496.1_Missense_Mutation_p.E364K|SLC9C2_ENST00000466087.1_5'UTR	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	466					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										AAAATTTTTTCTGTTTTAAAT	0.348000													34	31					0	0	0.002836	0	0
WDFY3	23001	broad.mit.edu	37	4	85695995	85695995	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:85695995G>A	ENST00000322366.6	-	29	5139	c.4732C>T	c.(4732-4734)Cct>Tct	p.P1578S	WDFY3_ENST00000295888.4_Missense_Mutation_p.P1578S			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1578						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTGCTGCTAGGAAAACCTTGC	0.378000													28	65					0	0	0.005443	0	0
FGR	2268	broad.mit.edu	37	1	27942047	27942047	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:27942047C>T	ENST00000374005.3	-	9	1204	c.916G>A	c.(916-918)Gag>Aag	p.E306K	FGR_ENST00000399173.1_Missense_Mutation_p.E306K|FGR_ENST00000545953.1_Missense_Mutation_p.E240K|FGR_ENST00000374004.1_Missense_Mutation_p.E306K	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	306	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ACCTGCGCCTCCTCCAGGAAG	0.622000													6	42					0	0	0.001168	0	0
LOXL2	4017	broad.mit.edu	37	8	23167234	23167234	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:23167234G>A	ENST00000389131.3	-	10	2196	c.1827C>T	c.(1825-1827)tcC>tcT	p.S609S		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	609	Lysyl-oxidase like.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		GCCGGAAGTCGGACTGGCCAT	0.677000													16	22					0	0	0.004990	0	0
GRIA1	2890	broad.mit.edu	37	5	153144012	153144012	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:153144012C>T	ENST00000285900.5	+	12	2185	c.1842C>T	c.(1840-1842)atC>atT	p.I614I	GRIA1_ENST00000448073.4_Silent_p.I624I|GRIA1_ENST00000518783.1_Silent_p.I624I|GRIA1_ENST00000521843.2_Silent_p.I545I|GRIA1_ENST00000340592.5_Silent_p.I614I|GRIA1_ENST00000518142.1_Silent_p.I534I	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	614					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTGGTCGCATCGTTGGTGGCG	0.572000													22	66					0	0	0.003954	0	0
TACC1	6867	broad.mit.edu	37	8	38699875	38699875	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr8:38699875C>T	ENST00000379931.3	+	11	2446	c.2067C>T	c.(2065-2067)gcC>gcT	p.A689A	TACC1_ENST00000520973.1_Silent_p.A453A|TACC1_ENST00000330691.6_Silent_p.A251A|TACC1_ENST00000443286.2_Silent_p.A664A|TACC1_ENST00000348567.4_Silent_p.A239A|TACC1_ENST00000520615.1_Silent_p.A482A|TACC1_ENST00000518415.1_Silent_p.A603A|TACC1_ENST00000520611.1_Silent_p.A114A|TACC1_ENST00000317827.4_Silent_p.A677A|TACC1_ENST00000276520.8_Silent_p.A267A|TACC1_ENST00000519416.1_Silent_p.A481A			O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing protein 1	677					cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			breast(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(3)	17		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			AGGAACAGGCCCTGGCTGACC	0.458000													25	144					0	0	0.002780	0	0
TRIM3	10612	broad.mit.edu	37	11	6477304	6477304	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:6477304G>A	ENST00000525074.1	-	7	1925	c.1531C>T	c.(1531-1533)Cag>Tag	p.Q511*	TRIM3_ENST00000345851.3_Nonsense_Mutation_p.Q511*|TRIM3_ENST00000537602.1_Nonsense_Mutation_p.Q433*|TRIM3_ENST00000536344.1_Nonsense_Mutation_p.Q392*|TRIM3_ENST00000359518.3_Nonsense_Mutation_p.Q511*	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	511					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGCTTACCTGAATACACTGG	0.493000													15	46					0	0	0.004990	0	0
COL6A6	131873	broad.mit.edu	37	3	130345357	130345357	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:130345357G>A	ENST00000358511.6	+	24	4938	c.4907G>A	c.(4906-4908)gGa>gAa	p.G1636E	COL6A6_ENST00000453409.2_Missense_Mutation_p.G1636E	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1636	Triple-helical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GGAGAAAAAGGAGCTGTTGGC	0.418000													26	73					0	0	0.008361	0	0
LDHAL6A	160287	broad.mit.edu	37	11	18485507	18485507	+	Splice_Site	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:18485507G>A	ENST00000280706.2	+	2	923		c.e2-1		LDHAL6A_ENST00000396213.3_Splice_Site	NM_144972.4	NP_659409.2	Q6ZMR3	LDH6A_HUMAN	lactate dehydrogenase A-like 6A						glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity			large_intestine(3)|lung(9)|urinary_tract(1)	13					NADH(DB00157)	ATGTTTTTCAGGGTTTGAGTG	0.383000													16	32					0	0	0.004990	0	0
ZBBX	79740	broad.mit.edu	37	3	166960418	166960418	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:166960418C>T	ENST00000392766.2	-	20	2491	c.2151G>A	c.(2149-2151)aaG>aaA	p.K717K	ZBBX_ENST00000392764.1_Silent_p.K688K|ZBBX_ENST00000455345.2_Silent_p.K756K|ZBBX_ENST00000307529.5_Silent_p.K756K|ZBBX_ENST00000392767.2_Silent_p.K717K	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	717						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						AGCTGTAAAGCTTTTCTGAAG	0.353000													10	30					0	0	0.006214	0	0
ENAM	10117	broad.mit.edu	37	4	71503529	71503529	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:71503529G>A	ENST00000396073.3	+	8	838	c.557G>A	c.(556-558)gGa>gAa	p.G186E	ENAM_ENST00000472903.1_3'UTR	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	186					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			CCAGGTTATGGACGCCCACCA	0.453000													46	120					0	0	0.003610	0	0
FLG	2312	broad.mit.edu	37	1	152276755	152276755	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:152276755C>T	ENST00000368799.1	-	3	10642	c.10607G>A	c.(10606-10608)gGa>gAa	p.G3536E	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3536	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AACACTGGATCCCTGGTTCCT	0.577000									Ichthyosis				152	166					0	0	0.003610	0	0
CABP4	57010	broad.mit.edu	37	11	67223069	67223069	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:67223069G>A	ENST00000325656.5	+	1	252	c.175G>A	c.(175-177)Ggg>Agg	p.G59R	CABP4_ENST00000438189.2_Intron|CABP4_ENST00000542025.2_3'UTR	NM_145200.3	NP_660201.1	P57796	CABP4_HUMAN	calcium binding protein 4	59					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding			central_nervous_system(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(2)	11			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			TGGCAGCTCTGGGGAGCAGAC	0.687000													8	17					0	0	0.003080	0	0
NKTR	4820	broad.mit.edu	37	3	42680879	42680879	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:42680879C>T	ENST00000232978.8	+	13	3871	c.3683C>T	c.(3682-3684)cCc>cTc	p.P1228L	RP4-613B23.1_ENST00000445452.1_RNA|RP4-613B23.1_ENST00000434363.1_RNA|RP4-613B23.1_ENST00000438017.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1228					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		AAATGGAAGCCCCTGCAAGGT	0.527000													18	66					0	0	0.008871	0	0
MUC4	4585	broad.mit.edu	37	3	195493597	195493597	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:195493597G>A	ENST00000463781.3	-	8	14014	c.13555C>T	c.(13555-13557)Cca>Tca	p.P4519S	MUC4_ENST00000349607.4_Missense_Mutation_p.P232S|MUC4_ENST00000346145.4_Missense_Mutation_p.P283S|MUC4_ENST00000475231.1_Missense_Mutation_p.P4467S	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1276					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GACATCAGTGGGCTGTTTTCG	0.537000													12	33					0	0	0.003163	0	0
RAPGEF1	2889	broad.mit.edu	37	9	134471740	134471740	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr9:134471740G>A	ENST00000372195.1	-	14	2370	c.2127C>T	c.(2125-2127)gtC>gtT	p.V709V	RAPGEF1_ENST00000372189.3_Silent_p.V692V|RAPGEF1_ENST00000372190.3_Silent_p.V710V			Q13905	RPGF1_HUMAN	Rap guanine nucleotide exchange factor (GEF) 1	692	N-terminal Ras-GEF.				activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	39		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		ATCCTCCGCGGACGTCCGGCC	0.542000													6	9					0	0	0.006214	0	0
TPX2	22974	broad.mit.edu	37	20	30381768	30381768	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr20:30381768C>T	ENST00000340513.4	+	15	2263	c.1735C>T	c.(1735-1737)Cga>Tga	p.R579*	TPX2_ENST00000300403.6_Nonsense_Mutation_p.R543*			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	543					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			GTTTGATTCTCGAGACAAAGA	0.418000													34	80					0	0	0.002836	0	0
ADCY3	109	broad.mit.edu	37	2	25057785	25057785	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:25057785G>A	ENST00000260600.5	-	9	2534	c.1683C>T	c.(1681-1683)ccC>ccT	p.P561P	ADCY3_ENST00000405392.1_Silent_p.P194P	NM_004036.3	NP_004027.2	O60266	ADCY3_HUMAN	adenylate cyclase 3	561					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			NS(1)|breast(5)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(4)|skin(2)	44	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GGCGTGGGTTGGGGAATGAGG	0.642000													11	22					0	0	0.001368	0	0
RGL1	23179	broad.mit.edu	37	1	183775610	183775610	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:183775610A>T	ENST00000304685.3	+	3	695	c.234A>T	c.(232-234)agA>agT	p.R78S	RGL1_ENST00000360851.3_Missense_Mutation_p.R43S|RGL1_ENST00000367531.1_Missense_Mutation_p.R78S|RGL1_ENST00000536277.1_Intron|RGL1_ENST00000539189.1_Missense_Mutation_p.R43S	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	43	N-terminal Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						AAGGAGCAAGATGGCTAGGGG	0.453000													23	103					0	0	0.001882	0	0
MEIS3	56917	broad.mit.edu	37	19	47910355	47910355	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:47910355G>A	ENST00000331559.5	-	10	1503	c.1062C>T	c.(1060-1062)atC>atT	p.I354I	MEIS3_ENST00000561293.1_Silent_p.I371I|MEIS3_ENST00000560253.1_5'UTR|MEIS3_ENST00000561096.1_Silent_p.I413I|MEIS3_ENST00000559524.1_Silent_p.I371I|MEIS3_ENST00000558555.1_Silent_p.I325I|MEIS3_ENST00000441740.2_Silent_p.I308I	NM_020160.2	NP_064545.1	Q99687	MEIS3_HUMAN	Meis homeobox 3	325						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(5)|lung(11)|prostate(1)|skin(2)	20		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		TGGATTGATCGATCATAGGTT	0.612000													8	32					0	0	0.006214	0	0
INTS4P1	285905	broad.mit.edu	37	7	64639749	64639749	+	RNA	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:64639749C>T	ENST00000587624.1	+	0	632																											GCCTTGATTTCCTAGTTGACA	0.443000													4	18					0	0	0.001168	0	0
KCNG4	93107	broad.mit.edu	37	16	84270876	84270876	+	Silent	SNP	G	G	A	rs141435784		TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr16:84270876G>A	ENST00000568181.1	-	2	336	c.216C>T	c.(214-216)ctC>ctT	p.L72L	KCNG4_ENST00000308251.4_Silent_p.L72L			Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	72						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						TGCTCCAGGGGAGGAGATACC	0.617000													24	35					0	0	0.003954	0	0
RGS18	64407	broad.mit.edu	37	1	192153683	192153683	+	Nonstop_Mutation	SNP	A	A	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr1:192153683A>T	ENST00000367460.3	+	5	888	c.707A>T	c.(706-708)tAa>tTa	p.*236L		NM_130782.2	NP_570138.1	Q9NS28	RGS18_HUMAN	regulator of G-protein signaling 18	0					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			kidney(1)|large_intestine(2)|lung(15)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						ATTTGGTTATAAAGAAAATTG	0.348000													6	47					0	0	0.001168	0	0
ENAM	10117	broad.mit.edu	37	4	71510396	71510396	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:71510396G>A	ENST00000396073.3	+	9	3534	c.3253G>A	c.(3253-3255)Gat>Aat	p.D1085N	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	1085					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			ATTTGATGGGGATTCAATTAC	0.428000													16	61					0	0	0.004007	0	0
MYH13	8735	broad.mit.edu	37	17	10212703	10212703	+	Missense_Mutation	SNP	C	C	T	rs140856441	by1000genomes	TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:10212703C>T	ENST00000418404.3	-	34	5180	c.5017G>A	c.(5017-5019)Gag>Aag	p.E1673K	MYH13_ENST00000570743.1_Missense_Mutation_p.E1673K|MYH13_ENST00000252172.4_Missense_Mutation_p.E1673K			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1673					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GCCAGCTGCTCCTTGAGGTCC	0.657000													11	14					0	0	0.008291	0	0
ATRNL1	26033	broad.mit.edu	37	10	117001393	117001393	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr10:117001393C>T	ENST00000355044.3	+	10	1692	c.1566C>T	c.(1564-1566)taC>taT	p.Y522Y		NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	522						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TTGCCAGATACCTTCATTCAG	0.333000													14	30					0	0	0.003163	0	0
RASGRF1	5923	broad.mit.edu	37	15	79296400	79296400	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr15:79296400C>G	ENST00000419573.3	-	16	2515	c.2241G>C	c.(2239-2241)aaG>aaC	p.K747N	RASGRF1_ENST00000394745.3_5'UTR|RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000558480.2_Missense_Mutation_p.K731N	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	747	N-terminal Ras-GEF.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GTGACGATGTCTTGGTGATGG	0.637000													37	83					0	0	0.005524	0	0
CLIP2	7461	broad.mit.edu	37	7	73814775	73814775	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:73814775C>T	ENST00000223398.6	+	15	3283	c.2956C>T	c.(2956-2958)Ctg>Ttg	p.L986L	CLIP2_ENST00000361545.5_Silent_p.L951L|CLIP2_ENST00000395060.1_Silent_p.L986L	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	986						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						GCTTCTGCGGCTGCAGCACCA	0.632000													12	29					0	0	0.001368	0	0
IGKV1D-17	28900	broad.mit.edu	37	2	90121877	90121877	+	RNA	SNP	C	C	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr2:90121877C>A	ENST00000483379.1	+	0	276																											TCTCCATCTGCCATGTCTGCA	0.448000													50	146					6.3008e-33	7.21571e-33	0.003610	1	0
PRR11	55771	broad.mit.edu	37	17	57262485	57262485	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:57262485C>T	ENST00000262293.4	+	3	511	c.199C>T	c.(199-201)Cct>Tct	p.P67S		NM_018304.3	NP_060774.2	Q96HE9	PRR11_HUMAN	proline rich 11	67										breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|pancreas(1)	16	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CTTCAATTTTCCTAACATCAG	0.373000													24	72					0	0	0.003330	0	0
OR8H2	390151	broad.mit.edu	37	11	55872707	55872707	+	Silent	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:55872707C>T	ENST00000313503.1	+	1	189	c.189C>T	c.(187-189)ttC>ttT	p.F63F		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TGTATTTTTTCCTTACTCACC	0.418000										HNSCC(53;0.14)			60	209					0	0	0.003610	0	0
LAMA1	284217	broad.mit.edu	37	18	6962005	6962005	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr18:6962005G>A	ENST00000389658.3	-	52	7484	c.7391C>T	c.(7390-7392)tCc>tTc	p.S2464F		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2464	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTTGATCTGGATATTTCCAG	0.393000													40	90					0	0	0.002522	0	0
ZNF878	729747	broad.mit.edu	37	19	12155673	12155673	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:12155673A>C	ENST00000602107.1	-	5	683	c.684T>G	c.(682-684)agT>agG	p.S228R	ZNF878_ENST00000547628.1_Missense_Mutation_p.S181R|CTD-2006C1.2_ENST00000591898.1_RNA|CTD-2006C1.2_ENST00000591838.1_RNA|CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000476474.1_RNA			C9JN71	ZN878_HUMAN	zinc finger protein 878	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						AACTGGGAAAACTGAATGCTT	0.403000													4	269					0	0	0.000248	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140762923	140762923	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr5:140762923C>T	ENST00000518325.1	+	1	457	c.457C>T	c.(457-459)Ccg>Tcg	p.P153S	PCDHGB3_ENST00000576222.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTTCGGTTTCCGTTAAGCGA	0.473000													20	35					0	0	0.007413	0	0
VARS	7407	broad.mit.edu	37	6	31760655	31760655	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr6:31760655G>A	ENST00000375663.3	-	4	980	c.540C>T	c.(538-540)gcC>gcT	p.A180A	VARS_ENST00000444930.2_5'UTR	NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	180	GST C-terminal.				translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	AGATCCGGCGGGCAGGTGGGT	0.542000													42	164					0	0	0.003214	0	0
COPS2	9318	broad.mit.edu	37	15	49437178	49437178	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr15:49437178A>G	ENST00000388901.5	-	2	225	c.152T>C	c.(151-153)tTa>tCa	p.L51S	COPS2_ENST00000299259.6_Missense_Mutation_p.L51S|COPS2_ENST00000542928.1_Intron	NM_001143887.1|NM_004236.3	NP_001137359.1|NP_004227.1	P61201	CSN2_HUMAN	COP9 signalosome subunit 2	51					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(2)	18		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		GAAACTGCTTAATGCCGCTTT	0.328000													21	67					0	0	0.001523	0	0
FGF12	2257	broad.mit.edu	37	3	192125997	192125997	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:192125997C>T	ENST00000454309.2	-	1	841	c.16G>A	c.(16-18)Gcc>Acc	p.A6T	FGF12_ENST00000450716.1_Intron|FGF12_ENST00000264730.3_Intron|FGF12_ENST00000430714.1_Intron|FGF12_ENST00000445105.1_Intron	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	6					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		AAGGAGCTGGCTATCGCCGCA	0.716000													8	18					0	0	0.006214	0	0
NXF1	10482	broad.mit.edu	37	11	62569486	62569486	+	Silent	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr11:62569486G>A	ENST00000531709.2	-	5	599	c.486C>T	c.(484-486)ttC>ttT	p.F162F	NXF1_ENST00000531131.1_5'UTR|NXF1_ENST00000294172.2_Silent_p.F162F|NXF1_ENST00000439713.2_Silent_p.F162F|NXF1_ENST00000532297.1_Silent_p.F162F	NM_001081491.1	NP_001074960.1	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1	162	Interaction with THOC4.|RRM.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CGTCTTCAACGAAGAACTGGG	0.522000													32	93					0	0	0.001786	0	0
MPP6	51678	broad.mit.edu	37	7	24703288	24703288	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:24703288C>T	ENST00000396475.2	+	7	1030	c.731C>T	c.(730-732)tCc>tTc	p.S244F	MPP6_ENST00000222644.4_Missense_Mutation_p.S244F|MPP6_ENST00000409761.1_Missense_Mutation_p.S132F	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	244	SH3.				protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						TTGAAGTTTTCCAAAGGAGAG	0.338000													17	57					0	0	0.004007	0	0
BAGE2	85319	broad.mit.edu	37	21	11047540	11047540	+	RNA	SNP	G	G	A			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr21:11047540G>A	ENST00000470054.1	-	0	714									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAAAAAGTATGATACCCTTTG	0.328000													9	326					0	0	0.008291	0	0
KANK3	256949	broad.mit.edu	37	19	8389978	8389978	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:8389978C>T	ENST00000330915.3	-	8	2004	c.1939G>A	c.(1939-1941)Gcc>Acc	p.A647T	KANK3_ENST00000593649.1_Missense_Mutation_p.A647T	NM_198471.2	NP_940873.2	Q6NY19	KANK3_HUMAN	KN motif and ankyrin repeat domains 3	647										breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						ACCTCGCAGGCCCCTGGGAGA	0.642000													8	32					0	0	0.003080	0	0
ANGEL1	23357	broad.mit.edu	37	14	77269745	77269745	+	Silent	SNP	G	G	A	rs149469500	byFrequency	TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr14:77269745G>A	ENST00000251089.2	-	7	1699	c.1587C>T	c.(1585-1587)gtC>gtT	p.V529V	ANGEL1_ENST00000557179.1_Silent_p.V94V	NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	529										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		CTTCCATAAGGACCAGTCCTA	0.473000													8	55					0	0	0.006214	0	0
XPC	7508	broad.mit.edu	37	3	14219966	14219968	+	Splice_Site	DEL	CCT	CCT	-	rs72561774		TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr3:14219966_14219968delCCT	ENST00000285021.7	-	1	315_317	c.103_splice	c.e1+1	p.ED34_splice	LSM3_ENST00000306024.3_5'UTR|XPC_ENST00000449060.2_Splice_Site_p.ED34_splice	NM_001145769.1|NM_004628.4	NP_001139241.1|NP_004619.3	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	34	Glu-rich (acidic).|Poly-Glu.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding	p.E34delE(1)		NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TCGCTCTCACCCTCCTCCTCCTC	0.734			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				9	73	---	---	---	---					
FAM149A	25854	broad.mit.edu	37	4	187074920	187074921	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr4:187074920_187074921delAG	ENST00000356371.5	+	5	1081_1082	c.1081_1082delAG	c.(1081-1083)afs	p.R361fs	FAM149A_ENST00000227065.4_Frame_Shift_Del_p.R70fs|FAM149A_ENST00000514153.1_Frame_Shift_Del_p.R70fs|FAM149A_ENST00000389354.5_Frame_Shift_Del_p.R70fs|FAM149A_ENST00000514829.1_3'UTR|FAM149A_ENST00000502970.1_Frame_Shift_Del_p.R70fs|FAM149A_ENST00000503432.1_Frame_Shift_Del_p.R70fs			A5PLN7	F149A_HUMAN	family with sequence similarity 149, member A	361										breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(2)	25		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		CAGCAACATCAGAGAGTATGTT	0.485													39	131	---	---	---	---					
GUSB	2990	broad.mit.edu	37	7	65447032	65447048	+	Frame_Shift_Del	DEL	AGCTCCAGAGGCCGTCC	AGCTCCAGAGGCCGTCC	-			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:65447032_65447048delAGCTCCAGAGGCCGTCC	ENST00000304895.4	-	1	253_269	c.123_139delGGACGGCCTCTGGAGCT	c.(121-141)cttcfs	p.LDGLWSF41fs	GUSB_ENST00000345660.6_Frame_Shift_Del_p.LDGLWSF41fs|GUSB_ENST00000421103.1_Frame_Shift_Del_p.LDGLWSF41fs	NM_000181.3	NP_000172.2	P08236	BGLR_HUMAN	glucuronidase, beta	41					glycosaminoglycan catabolic process	lysosome	beta-glucuronidase activity|cation binding			breast(1)|cervix(2)|kidney(2)|large_intestine(4)|lung(10)|skin(1)	20						TCGGCGCGGAAGCTCCAGAGGCCGTCCAGCTCCTTGC	0.733													10	42	---	---	---	---					
PRKAR2B	5577	broad.mit.edu	37	7	106685616	106685618	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:106685616_106685618delGGA	ENST00000265717.4	+	1	523_525	c.264_266delGGA	c.(262-267)ggg>gg	p.GE88del		NM_002736.2	NP_002727.2	P31323	KAP3_HUMAN	protein kinase, cAMP-dependent, regulatory, type II, beta	88	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	14						CCGAGGACGGGGAGGAGGAGGAG	0.754													2	4	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149518533	149518533	+	RNA	DEL	C	C	-	rs11353848		TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr7:149518533delC	ENST00000378016.2	+	0	12602							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGGAGCAGTCCCAGAGCCAG	0.711													3	4	---	---	---	---					
GSN	2934	broad.mit.edu	37	9	124093745	124093745	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr9:124093745delG	ENST00000373807.1	+	12	2400	c.1391delG	c.(1390-1392)tgfs	p.W464fs	GSN_ENST00000412819.1_Intron|GSN_ENST00000373818.4_Intron|GSN_ENST00000545652.1_Intron|GSN_ENST00000394353.2_Intron|GSN_ENST00000341272.2_Intron|GSN_ENST00000436847.1_Intron|GSN_ENST00000373806.1_Intron|GSN_ENST00000373823.3_Intron|GSN_ENST00000449733.1_Intron|GSN_ENST00000373808.2_Intron			P06396	GELS_HUMAN	gelsolin	0	Actin-binding, Ca-sensitive (Potential).				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)	21						CCGAGTGCCTGGGGGCGGGGG	0.562													2	4	---	---	---	---					
GOSR2	9570	broad.mit.edu	37	17	45017950	45017950	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr17:45017950delT	ENST00000225567.4	+	7	644	c.613delT	c.(613-615)ttfs	p.F205fs	RP11-156P1.2_ENST00000571841.1_Intron|GOSR2_ENST00000439730.2_Intron	NM_054022.2	NP_473363.1	O14653	GOSR2_HUMAN	golgi SNAP receptor complex member 2	0					cellular membrane fusion|ER to Golgi vesicle-mediated transport|protein transport	Golgi membrane|integral to membrane	transporter activity			kidney(1)|large_intestine(2)|liver(1)|lung(1)|ovary(1)|skin(1)	7			BRCA - Breast invasive adenocarcinoma(9;0.102)			GACAGCACACTTTGGAGGAAG	0.542											OREG0024493	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	48	105	---	---	---	---					
CTC-260E6.6	0	broad.mit.edu	37	19	20243404	20243405	+	RNA	DEL	AC	AC	-			TCGA-DA-A1I4-06A-11D-A196-08	TCGA-DA-A1I4-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fa4fa2-b533-4d77-8522-ee29bbf2cb94	d574b360-78b4-4cfb-9c89-90acbff0a4b7	g.chr19:20243404_20243405delAC	ENST00000590606.1	-	0	188				CTC-260E6.6_ENST00000593655.1_RNA|CTC-260E6.6_ENST00000586657.1_RNA																							TCCCTGGAAAACACACACACAC	0.411													7	68	---	---	---	---