Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CYP19A1	1588	broad.mit.edu	37	15	51504750	51504750	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:51504750C>G	ENST00000396402.1	-	9	1183	c.1030G>C	c.(1030-1032)Gac>Cac	p.D344H	CYP19A1_ENST00000260433.2_Missense_Mutation_p.D344H|CYP19A1_ENST00000396404.4_Missense_Mutation_p.D344H|CYP19A1_ENST00000559878.1_Missense_Mutation_p.D344H|RP11-108K3.1_ENST00000559909.1_lincRNA	NM_000103.3	NP_000094.2	P11511	CP19A_HUMAN	cytochrome P450, family 19, subfamily A, polypeptide 1	344					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			endometrium(1)|kidney(4)|large_intestine(9)|lung(11)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	33				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	ATCTTTATGTCTCTCTCACCT	0.373000													22	13					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122775078	122775078	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:122775078G>A	ENST00000227349.2	+	3	1087	c.790G>A	c.(790-792)Gga>Aga	p.G264R	C11orf63_ENST00000307257.6_Missense_Mutation_p.G264R|C11orf63_ENST00000531316.1_Missense_Mutation_p.G264R	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	264										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GCTCACTTTGGGATTACCCAC	0.443000													52	63					0	0	1	0	0
USP16	10600	broad.mit.edu	37	21	30422476	30422476	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr21:30422476C>T	ENST00000334352.4	+	17	2401	c.2170C>T	c.(2170-2172)Cct>Tct	p.P724S	USP16_ENST00000535828.1_Missense_Mutation_p.P353S|USP16_ENST00000399976.2_Missense_Mutation_p.P724S|USP16_ENST00000399975.3_Missense_Mutation_p.P723S	NM_001032410.1	NP_001027582.1	Q9Y5T5	UBP16_HUMAN	ubiquitin specific peptidase 16	724					cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(2)	34						AGATTTGGCTCCTTTTTGCAC	0.368000													12	15					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55501547	55501547	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:55501547C>T	ENST00000543010.1	+	9	2667	c.2524C>T	c.(2524-2526)Ctg>Ttg	p.L842L	NLRP2_ENST00000263437.6_Silent_p.L839L|NLRP2_ENST00000448584.2_Silent_p.L842L|NLRP2_ENST00000538819.1_Silent_p.L818L|NLRP2_ENST00000427260.2_Silent_p.L819L|NLRP2_ENST00000339757.7_Silent_p.L820L|NLRP2_ENST00000391721.4_Silent_p.L818L|NLRP2_ENST00000537859.1_Silent_p.L820L	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	842					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CAAGTGCTTTCTGCAGAGGTT	0.517000													17	11					0	0	1	0	0
DCLRE1C	64421	broad.mit.edu	37	10	14977506	14977506	+	Silent	SNP	C	C	T	rs146832860	byFrequency	TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:14977506C>T	ENST00000453695.2	-	6	504	c.60G>A	c.(58-60)gcG>gcA	p.A20A	DCLRE1C_ENST00000378258.1_Silent_p.A20A|DCLRE1C_ENST00000378246.2_Silent_p.A25A|DCLRE1C_ENST00000378289.4_Silent_p.A140A|DCLRE1C_ENST00000378249.1_Silent_p.A25A|DCLRE1C_ENST00000378278.2_Silent_p.A140A|DCLRE1C_ENST00000357717.2_Silent_p.A25A|DCLRE1C_ENST00000378254.1_Silent_p.A20A|DCLRE1C_ENST00000396817.2_Silent_p.A20A|DCLRE1C_ENST00000378255.1_Silent_p.A20A	NM_001033855.1	NP_001029027.1	Q96SD1	DCR1C_HUMAN	DNA cross-link repair 1C	140					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	17						CTTCTCCTTGCGCCAATCTGA	0.403000								Non-homologous end-joining					63	11					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121767700	121767700	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:121767700G>A	ENST00000261367.7	+	8	2788	c.1360G>A	c.(1360-1362)Gaa>Aaa	p.E454K	SNCAIP_ENST00000542191.1_5'UTR|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379536.2_Missense_Mutation_p.E347K|SNCAIP_ENST00000504884.2_3'UTR|SNCAIP_ENST00000379533.2_Missense_Mutation_p.E454K|SNCAIP_ENST00000379538.3_Missense_Mutation_p.E41K|SNCAIP_ENST00000261368.8_Missense_Mutation_p.E407K|SNCAIP_ENST00000503116.2_Missense_Mutation_p.E454K			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	407					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GATGGTGAGCGAAACAGAAGC	0.393000													9	25					0	0	1	0	0
AHR	196	broad.mit.edu	37	7	17349706	17349706	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:17349706G>A	ENST00000242057.4	+	2	855	c.212G>A	c.(211-213)aGg>aAg	p.R71K		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	71	Helix-loop-helix motif.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					TCAGTTCTTAGGCTCAGCGTC	0.403000													16	33					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872986	55872986	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:55872986C>T	ENST00000313503.1	+	1	468	c.468C>T	c.(466-468)tcC>tcT	p.S156S		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TTATAGACTCCTTTGTCAACG	0.443000										HNSCC(53;0.14)			35	55					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24358111	24358111	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:24358111G>A	ENST00000005284.3	+	2	1470	c.268G>A	c.(268-270)Gaa>Aaa	p.E90K		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	90					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		TGCTGACTACGAACAGGACAC	0.562000													8	46					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176983946	176983946	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:176983946C>T	ENST00000367654.2	-	8	1541	c.1528G>A	c.(1528-1530)Gaa>Aaa	p.E510K	ASTN1_ENST00000367657.3_Missense_Mutation_p.E502K|ASTN1_ENST00000424564.2_Missense_Mutation_p.E502K|ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000361833.2_Missense_Mutation_p.E502K			O14525	ASTN1_HUMAN	astrotactin 1	510					cell migration|neuron cell-cell adhesion	integral to membrane		p.E502K(1)		NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GTCCCCCATTCGTTCCGAATG	0.493000													171	188					0	0	1	0	0
KBTBD12	166348	broad.mit.edu	37	3	127642822	127642822	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:127642822G>A	ENST00000405109.1	+	2	1385	c.918G>A	c.(916-918)cgG>cgA	p.R306R	KBTBD12_ENST00000407609.3_Intron|KBTBD12_ENST00000343941.4_Intron|KBTBD12_ENST00000405256.1_Silent_p.R306R			Q3ZCT8	KBTBC_HUMAN	kelch repeat and BTB (POZ) domain containing 12	306										endometrium(1)|large_intestine(6)|lung(5)|ovary(1)	13						CTGTATCACGGAAAACCTATT	0.418000													15	37					0	0	1	0	0
ITGB5	3693	broad.mit.edu	37	3	124515335	124515335	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:124515335G>A	ENST00000296181.4	-	10	1889	c.1593C>T	c.(1591-1593)aaC>aaT	p.N531N	ITGB5_ENST00000488466.1_5'UTR	NM_002213.3	NP_002204.2	P18084	ITB5_HUMAN	integrin, beta 5	531	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	30				GBM - Glioblastoma multiforme(114;0.163)		AGGAGCACTGGTTGCAGCTGC	0.607000													52	39					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56321563	56321563	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:56321563G>A	ENST00000443188.1	-	5	1123	c.413C>T	c.(412-414)tCt>tTt	p.S138F	NLRP11_ENST00000360133.3_Missense_Mutation_p.S138F|NLRP11_ENST00000589093.1_Missense_Mutation_p.S138F|NLRP11_ENST00000592953.1_Missense_Mutation_p.S39F|NLRP11_ENST00000589824.2_Missense_Mutation_p.S138F	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	138							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		ATAGCTGGTAGAATCATAGGC	0.368000													8	15					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100645221	100645221	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:100645221C>T	ENST00000471714.1	-	2	314	c.205G>A	c.(205-207)Gga>Aga	p.G69R	ABI3BP_ENST00000495063.1_Missense_Mutation_p.G69R|ABI3BP_ENST00000532144.1_5'UTR|ABI3BP_ENST00000284322.5_Missense_Mutation_p.G69R			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	69						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						CTGCCATATCCCAGGAGAAGA	0.468000													14	42					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2525366	2525366	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:2525366G>A	ENST00000288709.6	-	19	1967	c.1727C>T	c.(1726-1728)cCt>cTt	p.P576L	MMEL1_ENST00000378412.3_Missense_Mutation_p.P585L|MMEL1_ENST00000502556.1_Missense_Mutation_p.P428L	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	585					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		GATCCCGGCAGGGAATACTGT	0.597000													10	18					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35991268	35991268	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:35991268G>A	ENST00000274278.3	-	1	432	c.75C>T	c.(73-75)atC>atT	p.I25I	UGT3A1_ENST00000513233.1_5'UTR|UGT3A1_ENST00000507113.1_Silent_p.I25I|UGT3A1_ENST00000503189.1_Silent_p.I25I|UGT3A1_ENST00000333811.4_Intron	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	25						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATATTGTCAGGATTTTGGCAG	0.592000													23	109					0	0	1	0	0
EIF3G	8666	broad.mit.edu	37	19	10227829	10227829	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:10227829G>A	ENST00000253108.4	-	6	378	c.336C>T	c.(334-336)ccC>ccT	p.P112P		NM_003755.3	NP_003746.2	O75821	EIF3G_HUMAN	eukaryotic translation initiation factor 3, subunit G	112						cytosol|eukaryotic translation initiation factor 3 complex|nucleus|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity			central_nervous_system(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(20;3.53e-09)|Epithelial(33;4.91e-06)|all cancers(31;1.1e-05)			TGGGTCCGGGGGGGTCAAACT	0.602000													9	14					0	0	1	0	0
VCPIP1	80124	broad.mit.edu	37	8	67547092	67547092	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:67547092G>A	ENST00000310421.4	-	3	3571	c.3313C>T	c.(3313-3315)Cag>Tag	p.Q1105*		NM_025054.4	NP_079330.2	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex interacting protein 1	1105					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			breast(7)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(6)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			TTTTTTCGCTGGGCCTCAACC	0.448000													52	39					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38950520	38950520	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:38950520C>T	ENST00000302328.3	-	9	1465	c.1267G>A	c.(1267-1269)Gaa>Aaa	p.E423K	SCN11A_ENST00000456224.3_Missense_Mutation_p.E423K|SCN11A_ENST00000450244.1_Missense_Mutation_p.E423K|SCN11A_ENST00000444237.2_Missense_Mutation_p.E423K	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	423					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TGCTGGGCTTCCTGAAACATC	0.512000													29	60					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84526585	84526585	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:84526585A>T	ENST00000360700.4	+	10	3061	c.2175A>T	c.(2173-2175)aaA>aaT	p.K725N	ZNF711_ENST00000542798.1_Missense_Mutation_p.K521N|ZNF711_ENST00000395402.1_Missense_Mutation_p.K687N|ZNF711_ENST00000373165.3_Missense_Mutation_p.K679N|ZNF711_ENST00000276123.3_Missense_Mutation_p.K679N			Q9Y462	ZN711_HUMAN	zinc finger protein 711	679					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						TGAAATGTAAAAGGTGCAAGA	0.368000													19	47					0	0	1	0	0
ADCK4	79934	broad.mit.edu	37	19	41206337	41206337	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:41206337G>A	ENST00000324464.3	-	11	1214	c.913C>T	c.(913-915)Ccc>Tcc	p.P305S	ADCK4_ENST00000243583.6_Missense_Mutation_p.P264S|ADCK4_ENST00000450541.1_Missense_Mutation_p.P264S	NM_024876.3	NP_079152.3	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4	305	Protein kinase.					integral to membrane	protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(6)|stomach(2)|urinary_tract(1)	17			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			CGGAAGAAGGGGTCATTTGCC	0.632000													11	8					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179426007	179426007	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179426007G>A	ENST00000589042.1	-	326	85076	c.84852C>T	c.(84850-84852)atC>atT	p.I28284I	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000460472.2_Silent_p.I19219I|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Silent_p.I19344I|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Silent_p.I19411I|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.I26643I|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Silent_p.I25716I|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586831.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	26643	Ig-like 131.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTATCCTGTGATCTTAGCTC	0.393000													30	36					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585431	82585431	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:82585431C>T	ENST00000423517.2	-	5	5175	c.4838G>A	c.(4837-4839)cGa>cAa	p.R1613Q	PCLO_ENST00000333891.8_Missense_Mutation_p.R1613Q	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1544					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GCTACTTTTTCGAGTCAGTCG	0.418000													91	167					0	0	1	0	0
SLAMF1	6504	broad.mit.edu	37	1	160604595	160604595	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:160604595C>T	ENST00000302035.6	-	3	857	c.508G>A	c.(508-510)Gac>Aac	p.D170N	SLAMF1_ENST00000355199.3_Missense_Mutation_p.D170N|SLAMF1_ENST00000235739.5_Missense_Mutation_p.D170N|SLAMF1_ENST00000538290.1_Missense_Mutation_p.D170N	NM_003037.2	NP_003028.1	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family member 1	170	Ig-like C2-type.				interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GCCACATGGTCCCCCTTCTCC	0.582000													44	30					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28542497	28542497	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:28542497C>T	ENST00000452236.2	-	3	2602	c.1985G>A	c.(1984-1986)aGa>aAa	p.R662K		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	662					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						AGGCAAACTTCTTTGAATCTC	0.443000													28	109					0	0	1	0	0
NEU3	10825	broad.mit.edu	37	11	74705593	74705593	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:74705593C>T	ENST00000294064.4	+	2	1061	c.134C>T	c.(133-135)cCt>cTt	p.P45L	NEU3_ENST00000531619.1_Missense_Mutation_p.P45L|NEU3_ENST00000531509.1_Missense_Mutation_p.P45L|NEU3_ENST00000529024.1_Intron|NEU3_ENST00000544263.1_Missense_Mutation_p.P12L|NEU3_ENST00000534628.1_Missense_Mutation_p.P45L|NEU3_ENST00000532963.1_Intron|NEU3_ENST00000545272.1_Intron	NM_006656.5	NP_006647.3	A8K327	A8K327_HUMAN	sialidase 3 (membrane sialidase)	45										kidney(2)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	11						TTCAACAGCCCTCTGTTCCGG	0.522000													17	32					0	0	1	0	0
IL10RA	3587	broad.mit.edu	37	11	117859097	117859097	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:117859097G>A	ENST00000227752.3	+	2	188	c.67_splice	c.e2-1	p.G23_splice	IL10RA_ENST00000545409.1_5'UTR|IL10RA_ENST00000541785.1_Splice_Site_p.R3_splice|IL10RA_ENST00000533700.1_3'UTR	NM_001558.3	NP_001549.2	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha	23						integral to membrane|plasma membrane	interleukin-10 receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		TTCTCCCCAGGGACAGAGCTG	0.532000													20	23					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5566690	5566690	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:5566690G>A	ENST00000322653.4	-	1	89	c.64C>T	c.(64-66)Ctg>Ttg	p.L22L	HBG2_ENST00000380259.2_Intron	NM_001005289.1	NP_001005289.1	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H, member 1	22					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCCCTACCAGAATGAAGGGT	0.463000													10	27					0	0	1	0	0
TRPC1	7220	broad.mit.edu	37	3	142511672	142511672	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:142511672G>A	ENST00000273482.6	+	8	1733	c.1342G>A	c.(1342-1344)Gat>Aat	p.D448N	TRPC1_ENST00000476941.1_Missense_Mutation_p.D482N	NM_003304.4	NP_003295.1	P48995	TRPC1_HUMAN	transient receptor potential cation channel, subfamily C, member 1	482					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(2)|stomach(3)|urinary_tract(1)	37						TTAGTTTCATGATTTTGCTGA	0.358000													25	15					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164271441	164271441	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:164271441G>A	ENST00000515560.1	+	4	1538	c.16G>A	c.(16-18)Gac>Aac	p.D6N	NPY5R_ENST00000338566.3_Missense_Mutation_p.D6N|NPY5R_ENST00000506953.1_Missense_Mutation_p.D6N			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	6					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				TTTAGAGCTCGACGAGTATTA	0.363000													18	29					0	0	1	0	0
SIAH3	283514	broad.mit.edu	37	13	46357905	46357905	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:46357905G>A	ENST00000400405.2	-	2	529	c.423C>T	c.(421-423)atC>atT	p.I141I		NM_198849.2	NP_942146.2	Q8IW03	SIAH3_HUMAN	siah E3 ubiquitin protein ligase family member 3	141					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			large_intestine(3)|lung(7)|ovary(1)|skin(1)	12						CCAGGAAGACGATCTCGGCTC	0.617000													23	34					0	0	1	0	0
WBP5	51186	broad.mit.edu	37	X	102612855	102612855	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:102612855G>A	ENST00000372661.3	+	3	554	c.243G>A	c.(241-243)agG>agA	p.R81R	WBP5_ENST00000372656.3_Silent_p.R81R	NM_001006612.1|NM_016303.2	NP_001006613.1|NP_057387.1	Q9UHQ7	WPB5_HUMAN	WW domain binding protein 5	81										breast(2)|endometrium(2)|large_intestine(2)|ovary(1)|urinary_tract(1)	8						ATGAGATAAGGAGAGTCAGAA	0.343000													23	29					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70897032	70897032	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:70897032T>A	ENST00000393567.2	-	68	11675	c.11525A>T	c.(11524-11526)gAa>gTa	p.E3842V		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	3842										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TGAGGTATCTTCTGAGACCCA	0.478000													17	19					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179393863	179393863	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179393863C>T	ENST00000589042.1	-	360	106839	c.106615G>A	c.(106615-106617)Gaa>Aaa	p.E35539K	TTN-AS1_ENST00000587568.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E26474K|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000587944.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000604571.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E26599K|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E26666K|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E33898K|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E32971K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586831.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	33898							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGGAAATTTCCTCTTGGACA	0.378000													4	18					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42059304	42059304	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:42059304C>T	ENST00000219905.7	+	24	9205	c.9024C>T	c.(9022-9024)ctC>ctT	p.L3008L	MGA_ENST00000566586.1_Silent_p.L2799L|MGA_ENST00000570161.1_Silent_p.L3008L|MGA_ENST00000545763.1_Silent_p.L2799L|MGA_ENST00000389936.4_Silent_p.L2969L	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	2969						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GTCAGAGTCTCAAGGTGATGC	0.488000													12	45					0	0	1	0	0
CHSY1	22856	broad.mit.edu	37	15	101717755	101717755	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:101717755G>A	ENST00000254190.3	-	3	2722	c.2247C>T	c.(2245-2247)gtC>gtT	p.V749V	CHSY1_ENST00000543813.1_5'UTR	NM_014918.4	NP_055733.2	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	749					chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(5)|skin(1)	24	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GATCACAAAAGACAGGATGGT	0.532000													16	27					0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198257053	198257053	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:198257053G>A	ENST00000335508.5	-	25	3980	c.3889C>T	c.(3889-3891)Cgt>Tgt	p.R1297C		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	1297					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AGTTCATAACGAATATAGGTG	0.328000			Mis		myelodysplastic syndrome								14	20					0	0	1	0	0
C1orf85	112770	broad.mit.edu	37	1	156263909	156263909	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:156263909A>G	ENST00000362007.1	-	4	724	c.698T>C	c.(697-699)cTg>cCg	p.L233P	C1orf85_ENST00000472870.1_Intron|C1orf85_ENST00000368264.1_Missense_Mutation_p.L147P	NM_001256604.1|NM_001256609.1|NM_144580.2	NP_001243533.1|NP_001243538.1|NP_653181.1	Q8WWB7	NCUG1_HUMAN	chromosome 1 open reading frame 85	233					positive regulation of transcription from RNA polymerase II promoter	cytosol|integral to membrane|lysosomal membrane|nucleus	ligand-dependent nuclear receptor activity|protein binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(2)|prostate(2)|skin(3)	14	Hepatocellular(266;0.158)					CAGCCCAAACAGGGAACGGTT	0.632000													42	62					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52503971	52503971	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:52503971A>G	ENST00000261839.7	-	35	4413	c.4252T>C	c.(4252-4254)Tcc>Ccc	p.S1418P		NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	1418						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		TTCATGAGGGACTTCAGCATG	0.517000													61	45					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197029607	197029607	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:197029607C>T	ENST00000367412.1	-	5	737	c.694G>A	c.(694-696)Gaa>Aaa	p.E232K		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	232	Sushi 4.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						TCTCCTTCTTCATAGGTTTGC	0.294000													27	12					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30825328	30825328	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:30825328C>T	ENST00000383096.3	-	15	1656	c.1474G>A	c.(1474-1476)Gat>Aat	p.D492N	CCDC178_ENST00000402325.1_Missense_Mutation_p.D492N|CCDC178_ENST00000403303.1_Missense_Mutation_p.D492N|CCDC178_ENST00000583930.1_Missense_Mutation_p.D492N|CCDC178_ENST00000406524.2_Missense_Mutation_p.D492N|CCDC178_ENST00000300227.8_Missense_Mutation_p.D492N|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000579947.1_Missense_Mutation_p.D492N					coiled-coil domain containing 178																		AGATGTTTATCATTCTTTAAC	0.289000													11	7					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83636071	83636071	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:83636071C>T	ENST00000566620.1	+	8	1263	c.973C>T	c.(973-975)Ccc>Tcc	p.P325S	CDH13_ENST00000428848.3_Missense_Mutation_p.P286S|CDH13_ENST00000268613.10_Missense_Mutation_p.P372S	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	325	Cadherin 2.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TCTGGAAAATCCCAAGTATGA	0.448000													60	117					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117180229	117180229	+	Silent	SNP	C	C	T	rs75528968		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:117180229C>T	ENST00000003084.6	+	8	1077	c.945C>T	c.(943-945)ttC>ttT	p.F315F	CFTR_ENST00000454343.1_Silent_p.F315F	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	315	ABC transmembrane type-1 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TCTCAGGGTTCTTTGTGGTGT	0.398000									Cystic Fibrosis				21	47					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169837077	169837077	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:169837077G>A	ENST00000335742.7	+	17	3581	c.2224G>A	c.(2224-2226)Gaa>Aaa	p.E742K	PALLD_ENST00000512127.1_Missense_Mutation_p.E518K|PALLD_ENST00000507735.1_Missense_Mutation_p.E413K|PALLD_ENST00000505667.1_Missense_Mutation_p.E917K|CBR4_ENST00000509108.1_Intron|PALLD_ENST00000261509.6_Missense_Mutation_p.E900K			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	1124	Pro-rich.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CAGTGGAGACGAAAATGAACC	0.418000									Pancreatic Cancer, Familial Clustering of				14	28					0	0	1	0	0
COX10	1352	broad.mit.edu	37	17	14063198	14063198	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:14063198T>C	ENST00000261643.3	+	5	706	c.629T>C	c.(628-630)tTt>tCt	p.F210S	COX10_ENST00000537334.1_5'UTR|COX10_ENST00000536205.1_Missense_Mutation_p.F18S	NM_001303.3	NP_001294.2	Q12887	COX10_HUMAN	cytochrome c oxidase assembly homolog 10 (yeast)	210					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		TTACAGTTTTTTGAGGTGCCA	0.333000													11	10					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143089673	143089673	+	Splice_Site	SNP	T	T	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:143089673T>A	ENST00000367603.2	-	6	5930	c.5187_splice	c.e6-1	p.M1730_splice	HIVEP2_ENST00000367604.1_Splice_Site_p.M1730_splice|HIVEP2_ENST00000012134.2_Splice_Site_p.M1730_splice	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1730					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TCAGGTTTCATCTGTAAGACA	0.398000													10	13					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55889939	55889939	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:55889939C>G	ENST00000313472.3	+	1	91	c.91C>G	c.(91-93)Cta>Gta	p.L31V		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					TCTGTTTATGCTATTTCTCCT	0.458000													37	56					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115395159	115395159	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:115395159G>A	ENST00000393780.3	+	3	906	c.438G>A	c.(436-438)gaG>gaA	p.E146E	GAP43_ENST00000305124.6_Silent_p.E110E	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	110					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		CTCCTTCCGAGGAGAAGAAGG	0.622000													5	21					0	0	1	0	0
NEUROD1	4760	broad.mit.edu	37	2	182542525	182542525	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:182542525G>A	ENST00000295108.3	-	2	1520	c.1063C>T	c.(1063-1065)Cat>Tat	p.H355Y	CERKL_ENST00000479558.1_Intron|NEUROD1_ENST00000496876.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	355					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CTCTAATCATGAAATATGGCA	0.498000													31	131					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41539213	41539213	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr21:41539213G>A	ENST00000400454.1	-	16	3427	c.2950C>T	c.(2950-2952)Cct>Tct	p.P984S		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	984	Fibronectin type-III 2.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGACCATCAGGAGCTGTAAGG	0.522000													26	16					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131624167	131624167	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:131624167G>A	ENST00000512055.1	-	6	2247	c.121C>T	c.(121-123)Ctt>Ttt	p.L41F	CPNE4_ENST00000512332.1_Missense_Mutation_p.L59F|CPNE4_ENST00000429747.1_Missense_Mutation_p.L41F|CPNE4_ENST00000502818.1_Missense_Mutation_p.L59F|CPNE4_ENST00000511604.1_Missense_Mutation_p.L41F			Q96A23	CPNE4_HUMAN	copine IV	41	C2 1.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						GGTTTGGAAAGGGCATCTCTG	0.517000													21	27					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167096661	167096661	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:167096661G>A	ENST00000361200.2	+	6	2459	c.2293G>A	c.(2293-2295)Gat>Aat	p.D765N	DUSP27_ENST00000443333.1_Missense_Mutation_p.D765N|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.D765N			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	765					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CTGCCTGGGGGATGACCAAGT	0.567000													33	24					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151770083	151770083	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:151770083C>T	ENST00000535741.1	-	26	4699	c.4226G>A	c.(4225-4227)aGg>aAg	p.R1409K	LRBA_ENST00000510413.1_Missense_Mutation_p.R1409K|LRBA_ENST00000357115.3_Missense_Mutation_p.R1409K|LRBA_ENST00000507224.1_Missense_Mutation_p.R1409K			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1409						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					GCTAATTAGCCTCTGCAAAAA	0.358000													54	61					0	0	1	0	0
ZNF90	7643	broad.mit.edu	37	19	20229965	20229965	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:20229965G>A	ENST00000418063.2	+	4	1714	c.1602G>A	c.(1600-1602)gcG>gcA	p.A534A	ZNF90_ENST00000474284.1_Intron	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	534						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						ATACTGGAGCGAAACCCTACA	0.413000													7	15					0	0	1	0	0
DBF4B	80174	broad.mit.edu	37	17	42828498	42828498	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:42828498C>T	ENST00000315005.3	+	14	1863	c.1725C>T	c.(1723-1725)acC>acT	p.T575T	DBF4B_ENST00000393547.2_Intron	NM_145663.2	NP_663696.1	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B (S. cerevisiae)	575					cell cycle	nucleus	nucleic acid binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)	7		Prostate(33;0.0322)				ATCCGTGTACCCTTGCCTTCC	0.557000													21	78					0	0	1	0	0
POU6F1	5463	broad.mit.edu	37	12	51589769	51589769	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:51589769G>A	ENST00000389243.4	-	8	1172	c.233C>T	c.(232-234)tCc>tTc	p.S78F	POU6F1_ENST00000333640.10_Missense_Mutation_p.S78F|POU6F1_ENST00000550824.1_Missense_Mutation_p.S78F			Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	78	Gln/Pro-rich.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	11						CTTAGCAGGGGACTCAGGTGT	0.667000													7	3					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13901535	13901535	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:13901535C>T	ENST00000265104.4	-	14	1982	c.1878G>A	c.(1876-1878)aaG>aaA	p.K626K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	626	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCCACAAAATCTTTCCAGCGA	0.498000									Kartagener syndrome				12	16					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16282829	16282829	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:16282829G>A	ENST00000205557.7	-	13	1667	c.1638C>T	c.(1636-1638)gtC>gtT	p.V546V	ABCC6_ENST00000574094.1_5'UTR	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	546	ABC transmembrane type-1 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CCACCAGTGCGACCTGGGGGG	0.587000													16	55					0	0	1	0	0
GSKIP	51527	broad.mit.edu	37	14	96848745	96848745	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:96848745C>T	ENST00000556095.1	+	3	1973	c.161C>T	c.(160-162)tCg>tTg	p.S54L	GSKIP_ENST00000438650.1_Missense_Mutation_p.S54L|GSKIP_ENST00000554182.1_Missense_Mutation_p.S54L|GSKIP_ENST00000555181.1_Missense_Mutation_p.S54L	NM_001271904.1	NP_001258833.1			GSK3B interacting protein																		ATGTTTGTCTCGAAAAGCCTG	0.438000													28	7					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75672358	75672358	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:75672358G>A	ENST00000370855.5	-	24	2207	c.2094C>T	c.(2092-2094)ttC>ttT	p.F698F	SLC44A5_ENST00000370859.3_Intron|SLC44A5_ENST00000535611.1_Silent_p.F568F	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	698						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						TAGGGGTTACGAAGTAGGGTT	0.413000													71	36					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24416597	24416597	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:24416597C>T	ENST00000330966.7	-	13	1609	c.1447G>A	c.(1447-1449)Gat>Aat	p.D483N	MYOM3_ENST00000374434.3_Missense_Mutation_p.D482N|MYOM3_ENST00000329601.7_Missense_Mutation_p.D482N|MYOM3_ENST00000475306.1_5'UTR			Q5VTT5	MYOM3_HUMAN	myomesin 3	482										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TTTCCCAGATCAAAGGGGATC	0.572000													12	28					0	0	1	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31146210	31146210	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:31146210T>G	ENST00000304166.4	+	16	1608	c.1319T>G	c.(1318-1320)gTg>gGg	p.V440G	ADCYAP1R1_ENST00000409363.1_Missense_Mutation_p.V419G|ADCYAP1R1_ENST00000409489.1_Missense_Mutation_p.V496G|ADCYAP1R1_ENST00000396211.2_Missense_Mutation_p.V468G	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	440					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						AGCAGTGGGGTGAATGGGGGC	0.592000													24	22					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138683967	138683967	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr9:138683967C>T	ENST00000298480.5	+	32	3805	c.3731C>T	c.(3730-3732)tCg>tTg	p.S1244L	KCNT1_ENST00000371757.2_Missense_Mutation_p.S1223L|KCNT1_ENST00000491806.2_Missense_Mutation_p.S1209L|KCNT1_ENST00000488444.2_Missense_Mutation_p.S1223L|KCNT1_ENST00000487664.1_Missense_Mutation_p.S1199L|KCNT1_ENST00000263604.3_Missense_Mutation_p.S1218L|KCNT1_ENST00000490355.2_Missense_Mutation_p.S1222L|KCNT1_ENST00000486577.2_Missense_Mutation_p.S1201L			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	1223						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CACAAGCTGTCGTCCTGCAAC	0.667000													9	0					0	0	1	0	0
SKA1	220134	broad.mit.edu	37	18	47917627	47917627	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:47917627C>T	ENST00000285116.3	+	6	794	c.583C>T	c.(583-585)Cac>Tac	p.H195Y	SKA1_ENST00000488454.1_Missense_Mutation_p.H44Y|SKA1_ENST00000398452.2_Missense_Mutation_p.H195Y|SKA1_ENST00000417656.2_Missense_Mutation_p.H149Y	NM_001039535.2|NM_145060.3	NP_001034624.1|NP_659497.1	Q96BD8	SKA1_HUMAN	spindle and kinetochore associated complex subunit 1	195					cell division|chromosome segregation|mitotic anaphase|mitotic prometaphase|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytosol|spindle microtubule	microtubule binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(1)|prostate(1)	13						AAATCTCTATCACAGATTTAT	0.313000													13	21					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2908719	2908719	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:2908719C>T	ENST00000254695.8	+	15	1347	c.1257C>T	c.(1255-1257)ccC>ccT	p.P419P	RAP1GAP2_ENST00000540393.2_Silent_p.P400P|RAP1GAP2_ENST00000542807.1_Silent_p.P419P|RAP1GAP2_ENST00000366401.4_Silent_p.P404P	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	419	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						TGCCCAGTCCCCCCGTTTTCC	0.567000													21	79					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89480404	89480404	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:89480404C>T	ENST00000336596.2	+	13	2466	c.2241C>T	c.(2239-2241)ctC>ctT	p.L747L	EPHA3_ENST00000494014.1_Silent_p.L747L	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	747	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ACCGAGACCTCGCTGCTCGGA	0.493000										TSP Lung(6;0.00050)			13	12					0	0	1	0	0
ADCY1	107	broad.mit.edu	37	7	45725604	45725604	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:45725604C>T	ENST00000297323.7	+	13	2139	c.2117C>T	c.(2116-2118)tCc>tTc	p.S706F		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	706					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	CCCAACAGTTCCCTGGTGGTC	0.672000													23	31					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101581202	101581202	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:101581202C>T	ENST00000536262.2	-	7	1483	c.925G>A	c.(925-927)Gat>Aat	p.D309N		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	309					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GTCCAAGGATCACAGTCATGG	0.433000													19	2					0	0	1	0	0
SUSD4	55061	broad.mit.edu	37	1	223438058	223438058	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:223438058C>T	ENST00000343846.3	-	4	1271	c.638G>A	c.(637-639)gGa>gAa	p.G213E	SUSD4_ENST00000366878.4_Missense_Mutation_p.G213E|SUSD4_ENST00000344029.6_Missense_Mutation_p.G213E|SUSD4_ENST00000478605.1_Intron|SUSD4_ENST00000454695.2_Missense_Mutation_p.G53E			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	213	Sushi 3.					integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		AAGTTTAAATCCGGGAAAGCA	0.512000													39	40					0	0	1	0	0
ZNF77	58492	broad.mit.edu	37	19	2934718	2934718	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:2934718G>A	ENST00000314531.4	-	4	499	c.407C>T	c.(406-408)cCt>cTt	p.P136L		NM_021217.2	NP_067040.1	Q15935	ZNF77_HUMAN	zinc finger protein 77	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTTCGGTAGGGTAACTCTT	0.502000													19	77					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179598590	179598590	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179598590C>T	ENST00000589042.1	-	53	15750	c.15526G>A	c.(15526-15528)Gat>Aat	p.D5176N	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.D4859N|TTN_ENST00000342992.6_Missense_Mutation_p.D3932N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4859	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAATCAAATCATCTACTTTC	0.408000													19	29					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42227424	42227424	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:42227424G>A	ENST00000541110.1	-	9	2550	c.1982C>T	c.(1981-1983)gCc>gTc	p.A661V	TRERF1_ENST00000372922.4_Missense_Mutation_p.A641V|TRERF1_ENST00000372917.4_Missense_Mutation_p.A558V|TRERF1_ENST00000340840.2_Missense_Mutation_p.A558V|TRERF1_ENST00000354325.2_Missense_Mutation_p.A558V			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	641	Interacts with CREBBP.|Pro-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GGGCTCCTCGGCTTTGGGCAC	0.592000													35	32					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45262296	45262296	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:45262296C>T	ENST00000303230.4	-	8	2457	c.2400G>A	c.(2398-2400)ctG>ctA	p.L800L		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	800						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						GTCTGGAAATCAGAGTGGACA	0.657000													10	32					0	0	1	0	0
URAD	646625	broad.mit.edu	37	13	28562733	28562733	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:28562733G>A	ENST00000332715.4	-	1	41	c.42C>T	c.(40-42)ttC>ttT	p.F14F		NM_001105577.1	NP_001099047.1			ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase																		ACACATCCACGAATTCTCCAA	0.512000													21	33					0	0	1	0	0
CDKN1A	1026	broad.mit.edu	37	6	36653556	36653556	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:36653556C>T	ENST00000405375.1	+	3	709	c.474C>T	c.(472-474)atC>atT	p.I158I	CDKN1A_ENST00000448526.2_Silent_p.I192I|CDKN1A_ENST00000244741.5_Silent_p.I158I|CDKN1A_ENST00000373711.2_Silent_p.I158I	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	158					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						GCCGGCTGATCTTCTCCAAGA	0.577000													151	136					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126319984	126319984	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:126319984C>T	ENST00000394329.3	+	2	5234	c.5221C>T	c.(5221-5223)Cca>Tca	p.P1741S	FAT4_ENST00000335110.5_Missense_Mutation_p.P39S	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1741	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ACCAGTATTTCCAACGGACAT	0.443000													45	42					0	0	1	0	0
FAM194A	131831	broad.mit.edu	37	3	150377862	150377862	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:150377862G>A	ENST00000295910.6	-	14	1861	c.1809C>T	c.(1807-1809)atC>atT	p.I603I	FAM194A_ENST00000491361.1_Silent_p.I457I	NM_152394.3	NP_689607.2	Q7L0X2	F194A_HUMAN	family with sequence similarity 194, member A	603										NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						ACAGGCGACGGATCTTTATTA	0.418000													50	41					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129148820	129148820	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:129148820C>T	ENST00000540052.1	+	3	2116	c.2072C>T	c.(2071-2073)cCc>cTc	p.P691L	BCORL1_ENST00000359304.2_Missense_Mutation_p.P691L|BCORL1_ENST00000218147.7_Missense_Mutation_p.P691L|BCORL1_ENST00000303743.5_Missense_Mutation_p.P691L	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	691					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GTCATCTTTCCCGAGATCGTG	0.597000													24	42					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82455959	82455959	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:82455959C>T	ENST00000423517.2	-	18	14698	c.14361G>A	c.(14359-14361)ctG>ctA	p.L4787L	PCLO_ENST00000426442.2_5'UTR|PCLO_ENST00000333891.8_Silent_p.L4787L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4649					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTGTCACCTCCAGTGTTTTCT	0.353000													34	28					0	0	1	0	0
SNORA71C	677839	broad.mit.edu	37	20	37058369	37058369	+	RNA	SNP	A	A	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr20:37058369A>T	ENST00000364642.1	-	0	77					NR_003017.2																						AACACGGGGAAGTGCTCTCGG	0.602000													34	42					0	0	1	0	0
GLDN	342035	broad.mit.edu	37	15	51687050	51687050	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:51687050G>A	ENST00000335449.6	+	5	616	c.560G>A	c.(559-561)gGa>gAa	p.G187E	GLDN_ENST00000396399.2_Missense_Mutation_p.G63E	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	187	Collagen-like 1.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane		p.G187E(1)		central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		GGAGCTGCAGGAAATCCAGGG	0.488000													8	12					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:115256529T>C	ENST00000369535.4	-	3	435	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(817)|p.Q61L(175)|p.Q61P(23)|p.Q61K(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			91	28					0	0	1	0	0
EHD3	30845	broad.mit.edu	37	2	31457548	31457548	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:31457548G>A	ENST00000322054.5	+	1	346	c.61G>A	c.(61-63)Gtg>Atg	p.V21M	EHD3_ENST00000541626.1_Missense_Mutation_p.V21M	NM_014600.2	NP_055415.1	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	21					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|skin(3)	33	Acute lymphoblastic leukemia(172;0.155)					TTTCCAGACGGTGAGTGAGGG	0.652000													28	47					0	0	1	0	0
UVSSA	57654	broad.mit.edu	37	4	1343462	1343462	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:1343462C>T	ENST00000389851.4	+	3	696	c.249C>T	c.(247-249)ttC>ttT	p.F83F	UVSSA_ENST00000507531.1_Silent_p.F83F|UVSSA_ENST00000511216.1_Silent_p.F83F	NM_020894.2	NP_065945.2	Q2YD98	K1530_HUMAN	UV-stimulated scaffold protein A	83																	TTTCCAACTTCCAGGAGTTCC	0.647000													16	24					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10358358	10358358	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:10358358C>T	ENST00000255381.2	-	21	2445	c.2335G>A	c.(2335-2337)Gaa>Aaa	p.E779K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	779	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TCTCGCATTTCCTCTAGAGTT	0.418000													16	35					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152469313	152469313	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:152469313G>A	ENST00000367255.5	-	137	25444	c.24843C>T	c.(24841-24843)atC>atT	p.I8281I	SYNE1_ENST00000341594.5_Silent_p.I7893I|SYNE1_ENST00000265368.4_Silent_p.I8281I|SYNE1_ENST00000423061.1_Silent_p.I8210I|SYNE1_ENST00000356820.4_Silent_p.I2805I|SYNE1_ENST00000448038.1_Silent_p.I8210I|SYNE1_ENST00000539504.1_Silent_p.I436I|SYNE1_ENST00000354674.4_Silent_p.I436I|SYNE1_ENST00000347037.5_5'UTR	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8281					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACTCCAGGGGGATGGAGTCCA	0.597000										HNSCC(10;0.0054)			9	15					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138633289	138633289	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:138633289C>T	ENST00000218099.2	+	6	596	c.589C>T	c.(589-591)Cct>Tct	p.P197S	F9_ENST00000394090.2_Missense_Mutation_p.P159S	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	197					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	GACTGTTTTTCCTGATGTGGA	0.388000													26	36					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237880530	237880530	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:237880530G>A	ENST00000366574.2	+	72	10673	c.10356G>A	c.(10354-10356)atG>atA	p.M3452I	RYR2_ENST00000360064.6_Missense_Mutation_p.M3450I|RYR2_ENST00000542537.1_Missense_Mutation_p.M3436I	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3452					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGAAGAAAATGAAGCGCAAAG	0.483000													10	8					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10466207	10466207	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:10466207C>T	ENST00000382483.3	-	4	5624	c.5401G>A	c.(5401-5403)Gga>Aga	p.G1801R		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1801					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCAGTTTCTCCCCTTTCACTT	0.577000													48	133					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108029159	108029159	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:108029159C>T	ENST00000280758.5	+	12	3257	c.2729C>T	c.(2728-2730)tCg>tTg	p.S910L	BTBD11_ENST00000357167.4_Missense_Mutation_p.S447L|BTBD11_ENST00000490090.2_Missense_Mutation_p.S910L|BTBD11_ENST00000494235.2_5'UTR|BTBD11_ENST00000420571.2_Missense_Mutation_p.S791L	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	910						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						AAACAGACCTCGCGCTTGGGT	0.552000													22	5					0	0	1	0	0
PMS2	5395	broad.mit.edu	37	7	6026709	6026709	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:6026709G>A	ENST00000265849.7	-	11	1792	c.1687C>T	c.(1687-1689)Cga>Tga	p.R563*	PMS2_ENST00000382321.4_Intron|PMS2_ENST00000406569.3_Intron|PMS2_ENST00000441476.2_Nonsense_Mutation_p.R457*|PMS2_ENST00000469652.1_Intron	NM_000535.5	NP_000526.1	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	563					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding	p.R563*(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		GGCAAAACTCGAAATTTACAT	0.408000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				67	95					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76023395	76023395	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:76023395C>T	ENST00000393004.2	-	5	2374	c.2153G>A	c.(2152-2154)cGa>cAa	p.R718Q	FILIP1_ENST00000370020.1_Missense_Mutation_p.R619Q|FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Missense_Mutation_p.R718Q			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	718										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TTTTAAGTCTCGACTTTTAGC	0.403000													33	37					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196643044	196643044	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:196643044G>A	ENST00000367429.4	+	3	542	c.302G>A	c.(301-303)gGa>gAa	p.G101E	CFH_ENST00000439155.2_Missense_Mutation_p.G101E|CFH_ENST00000359637.2_Missense_Mutation_p.G101E	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	101	Sushi 2.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						CTTACAGGAGGAAATGTGTTT	0.343000													24	33					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82582551	82582551	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:82582551G>A	ENST00000423517.2	-	5	8055	c.7718C>T	c.(7717-7719)tCc>tTc	p.S2573F	PCLO_ENST00000333891.8_Missense_Mutation_p.S2573F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2504					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GAGGGATTTGGAAAATCTTGG	0.423000													42	75					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54785292	54785292	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:54785292C>T	ENST00000218436.6	-	8	1244	c.1215G>A	c.(1213-1215)acG>acA	p.T405T		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	405	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										CACTGGGGGTCGTCACGCCGG	0.602000													17	26					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101196777	101196777	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:101196777G>A	ENST00000294728.2	+	6	1329	c.1228G>A	c.(1228-1230)Gag>Aag	p.E410K	VCAM1_ENST00000347652.2_Missense_Mutation_p.E318K|VCAM1_ENST00000370115.1_Intron|VCAM1_ENST00000370119.4_Missense_Mutation_p.E348K	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	410	Ig-like C2-type 5.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	TCCAGAAATCGAGATGAGTGG	0.428000													23	8					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4732873	4732873	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:4732873C>T	ENST00000302640.8	+	31	4179	c.3829C>T	c.(3829-3831)Cag>Tag	p.Q1277*	ITPR1_ENST00000357086.4_Nonsense_Mutation_p.Q1283*|ITPR1_ENST00000443694.2_Nonsense_Mutation_p.Q1277*|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000423119.2_Nonsense_Mutation_p.Q1283*|ITPR1_ENST00000456211.2_Nonsense_Mutation_p.Q1268*|ITPR1_ENST00000354582.6_Nonsense_Mutation_p.Q1292*	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	1292					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GAACAATTTCCAGCTTTGCAG	0.448000													16	6					0	0	1	0	0
PHTF1	10745	broad.mit.edu	37	1	114280739	114280739	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:114280739G>A	ENST00000369604.1	-	5	807	c.324C>T	c.(322-324)ttC>ttT	p.F108F	PHTF1_ENST00000369600.1_Intron|PHTF1_ENST00000369596.2_Intron|PHTF1_ENST00000447664.2_Silent_p.F108F|PHTF1_ENST00000357783.2_Silent_p.F108F|PHTF1_ENST00000393357.2_Silent_p.F108F|PHTF1_ENST00000369598.1_Silent_p.F108F			Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	108						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACCTTGCATGAAATAAAGTA	0.343000													21	6					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107594984	107594984	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr9:107594984G>A	ENST00000374736.3	-	12	1774	c.1380C>T	c.(1378-1380)gcC>gcT	p.A460A		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	460					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CGATGTCTTGGGCTGTCCAAT	0.493000													16	16					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423853	56423853	+	Missense_Mutation	SNP	C	C	T	rs150988752		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:56423853C>T	ENST00000588751.1	-	5	1354	c.1330G>A	c.(1330-1332)Gat>Aat	p.D444N	NLRP13_ENST00000342929.3_Missense_Mutation_p.D444N			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	444	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GACTGGAGATCGTAATACCTC	0.483000													9	33					0	0	1	0	0
MMP13	4322	broad.mit.edu	37	11	102822852	102822852	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:102822852G>A	ENST00000260302.3	-	5	716	c.688C>T	c.(688-690)Ctt>Ttt	p.L230F	MMP13_ENST00000340273.4_Missense_Mutation_p.L230F	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	230					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		GAGTGGTCAAGACCTAAGGAG	0.458000													21	40					0	0	1	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947008	57947008	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:57947008T>A	ENST00000335397.3	+	3	408	c.92T>A	c.(91-93)tTt>tAt	p.F31Y		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				TTCCTCTTGTTTTTATTTATG	0.443000													25	31					0	0	1	0	0
GALNT16	57452	broad.mit.edu	37	14	69805411	69805411	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:69805411C>T	ENST00000337827.4	+	10	1338	c.1011C>T	c.(1009-1011)atC>atT	p.I337I	GALNT16_ENST00000448469.3_Silent_p.I337I|GALNT16_ENST00000553669.1_Silent_p.I337I	NM_001168368.1|NM_020692.2	NP_001161840.1|NP_065743.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		GTCTGGAGATCGTCCCCTGCA	0.582000													32	4					0	0	1	0	0
PARP15	165631	broad.mit.edu	37	3	122340368	122340368	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:122340368G>A	ENST00000483793.1	+	6	803	c.763G>A	c.(763-765)Gga>Aga	p.G255R	PARP15_ENST00000465304.1_3'UTR|PARP15_ENST00000310366.4_Missense_Mutation_p.G147R|PARP15_ENST00000464300.2_Missense_Mutation_p.G381R|PARP15_ENST00000493645.1_Missense_Mutation_p.G147R			Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	428					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0531)		TGTTCCTGGGGGAAAAGATGT	0.418000													12	41					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125103757	125103757	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:125103757C>T	ENST00000522917.1	+	34	4691	c.4485C>T	c.(4483-4485)caC>caT	p.H1495H	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Silent_p.H1495H	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1495						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CCTACTTTCACCCTGGGAAAA	0.453000													41	40					0	0	1	0	0
FAM117A	81558	broad.mit.edu	37	17	47788683	47788683	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:47788683G>A	ENST00000240364.2	-	8	1375	c.1296C>T	c.(1294-1296)ttC>ttT	p.F432F	RP11-613C6.2_ENST00000512720.1_RNA|FAM117A_ENST00000513602.1_Silent_p.F160F	NM_030802.3	NP_110429.1	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	432	Pro-rich.									haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	17						GCCATGGCTCGAATGGCAGTG	0.637000													14	9					0	0	1	0	0
ZNF445	353274	broad.mit.edu	37	3	44488909	44488909	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:44488909G>A	ENST00000425708.2	-	7	2595	c.2254C>T	c.(2254-2256)Cct>Tct	p.P752S	ZNF445_ENST00000396077.2_Missense_Mutation_p.P752S			P59923	ZN445_HUMAN	zinc finger protein 445	752					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		CTGCTCTGAGGAACCTGGAAC	0.493000													15	31					0	0	1	0	0
RNF152	220441	broad.mit.edu	37	18	59483100	59483100	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:59483100C>T	ENST00000312828.3	-	2	1696	c.597G>A	c.(595-597)gtG>gtA	p.V199V		NM_173557.2	NP_775828.1	Q8N8N0	RN152_HUMAN	ring finger protein 152	199					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)	17		Colorectal(73;0.186)				CACAGGATATCACAGTGAAGC	0.547000													34	26					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100490111	100490111	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:100490111G>A	ENST00000302913.4	-	3	1535	c.1397C>T	c.(1396-1398)tCc>tTc	p.S466F	ACHE_ENST00000411582.1_Missense_Mutation_p.S466F|ACHE_ENST00000241069.5_Missense_Mutation_p.S466F|ACHE_ENST00000428317.1_Missense_Mutation_p.S466F|ACHE_ENST00000412389.1_Missense_Mutation_p.S466F|ACHE_ENST00000419336.2_Missense_Mutation_p.S378F	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	466					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	GGAGAGCGTGGAAGCACGGTG	0.652000													58	36					0	0	1	0	0
RAB1A	5861	broad.mit.edu	37	2	65316200	65316200	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:65316200G>A	ENST00000409784.3	-	5	483	c.293C>T	c.(292-294)tCc>tTc	p.S98F	RAB1A_ENST00000409751.1_Missense_Mutation_p.S66F|RAB1A_ENST00000356214.7_Missense_Mutation_p.S66F|RAB1A_ENST00000260638.8_Intron|RAB1A_ENST00000398529.3_Intron|RAB1A_ENST00000494188.1_Intron|RAB1A_ENST00000409892.1_Missense_Mutation_p.S34F	NM_004161.4	NP_004152.1	P62820	RAB1A_HUMAN	RAB1A, member RAS oncogene family	98					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	GTP binding|GTPase activity			endometrium(1)|kidney(1)|lung(3)|prostate(1)	6						ATTATTGAAGGACTCCTAAAA	0.348000													4	7					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2966418	2966418	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:2966418C>T	ENST00000396946.4	-	14	2165	c.1762G>A	c.(1762-1764)Gaa>Aaa	p.E588K		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	588					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TTGTCTTCTTCGACTGTGCTG	0.567000			Mis		DLBCL								11	28					0	0	1	0	0
CUL4B	8450	broad.mit.edu	37	X	119708453	119708453	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:119708453C>T	ENST00000404115.3	-	2	421	c.20G>A	c.(19-21)gGa>gAa	p.G7E	CUL4B_ENST00000486604.1_5'UTR	NM_003588.3	NP_003579.3	Q13620	CUL4B_HUMAN	cullin 4B	7	Ser-rich.				cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						ATCTCCTGATCCAGATGACTG	0.388000													46	58					0	0	1	0	0
ZCCHC16	340595	broad.mit.edu	37	X	111698178	111698178	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:111698178C>T	ENST00000340433.2	+	1	452	c.222C>T	c.(220-222)ttC>ttT	p.F74F		NM_001004308.2	NP_001004308.2	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	74							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27						GCTCAGAGTTCCTCACTCAGG	0.483000													26	27					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110454425	110454425	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:110454425G>A	ENST00000260283.4	-	14	1736	c.1452C>T	c.(1450-1452)ctC>ctT	p.L484L	ARHGAP20_ENST00000524756.1_Silent_p.L461L|ARHGAP20_ENST00000529591.1_Silent_p.L27L|ARHGAP20_ENST00000357139.3_Silent_p.L458L|ARHGAP20_ENST00000528829.1_Silent_p.L448L|ARHGAP20_ENST00000527598.1_Silent_p.L448L|ARHGAP20_ENST00000533353.1_Silent_p.L458L	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	484	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GATACCTTAGGAGAACAACAT	0.378000													7	11					0	0	1	0	0
DCP1B	196513	broad.mit.edu	37	12	2074765	2074765	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:2074765T>A	ENST00000280665.6	-	5	560	c.481A>T	c.(481-483)Att>Ttt	p.I161F	DCP1B_ENST00000541700.1_Intron|DCP1B_ENST00000540622.1_Missense_Mutation_p.I35F|DCP1B_ENST00000397173.4_Missense_Mutation_p.I59F	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	161					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			ATTCGTAAAATGTCTACTTCT	0.448000													18	17					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3889456	3889456	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:3889456G>A	ENST00000520002.1	-	4	1136	c.581C>T	c.(580-582)tCg>tTg	p.S194L	CSMD1_ENST00000539096.1_Missense_Mutation_p.S194L|CSMD1_ENST00000537824.1_Missense_Mutation_p.S194L|CSMD1_ENST00000602723.1_Missense_Mutation_p.S194L|CSMD1_ENST00000602557.1_Missense_Mutation_p.S194L|CSMD1_ENST00000542608.1_Missense_Mutation_p.S194L|CSMD1_ENST00000400186.3_Missense_Mutation_p.S194L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	194	Sushi 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GAAGTCCCACGATGCACCATT	0.542000													12	5					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56539576	56539576	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:56539576G>A	ENST00000390649.3	+	7	1977	c.1977G>A	c.(1975-1977)ctG>ctA	p.L659L		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	659						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CCGTTCCCCTGGGGGTGAAGC	0.582000													15	57					0	0	1	0	0
DZIP1	22873	broad.mit.edu	37	13	96277043	96277043	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:96277043C>T	ENST00000347108.3	-	6	1383	c.951G>A	c.(949-951)tcG>tcA	p.S317S	DZIP1_ENST00000376829.2_Silent_p.S317S|DZIP1_ENST00000361396.2_Silent_p.S317S|DZIP1_ENST00000361156.3_Silent_p.S317S			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	317					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			CTGAATTCTTCGAAGTTAATT	0.348000													5	9					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40033394	40033394	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr20:40033394C>T	ENST00000373233.3	-	37	8164	c.7987G>A	c.(7987-7989)Gac>Aac	p.D2663N	CHD6_ENST00000480022.1_5'UTR	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2663				D -> G (in Ref. 1; AAK56405).	chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TTGGGGTTGTCCCCCTTTGTC	0.597000													48	48					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2876145	2876145	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:2876145G>A	ENST00000520002.1	-	53	8441	c.7886C>T	c.(7885-7887)cCc>cTc	p.P2629L	CSMD1_ENST00000537824.1_Missense_Mutation_p.P2628L|CSMD1_ENST00000602723.1_Intron|CSMD1_ENST00000602557.1_Missense_Mutation_p.P2629L|CSMD1_ENST00000542608.1_Intron|CSMD1_ENST00000400186.3_Intron			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2629	Sushi 17.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCCATTTGGGGGAAAGGAAAG	0.433000													20	52					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45929115	45929115	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr21:45929115G>A	ENST00000323084.4	-	10	1786	c.1721C>T	c.(1720-1722)gCc>gTc	p.A574V	TSPEAR_ENST00000397916.1_Missense_Mutation_p.A506V|TSPEAR-AS1_ENST00000451035.1_RNA	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	574					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						CTTGACAAAGGCCTGCGCGGT	0.562000													6	14					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531334	140531334	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:140531334C>T	ENST00000231136.1	+	1	1496	c.1496C>T	c.(1495-1497)tCt>tTt	p.S499F	PCDHB6_ENST00000543635.1_Missense_Mutation_p.S363F	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		499	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGCCCCTCTCTTCCCTGGTC	0.652000													95	13					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43674267	43674267	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:43674267G>A	ENST00000599812.1	-	6	1362	c.1267C>T	c.(1267-1269)Cct>Tct	p.P423S	PSG5_ENST00000342951.6_Missense_Mutation_p.P330S|PSG5_ENST00000407356.1_Missense_Mutation_p.P330S|PSG5_ENST00000407568.1_Missense_Mutation_p.P152S|PSG5_ENST00000366175.3_Missense_Mutation_p.P330S			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	330					female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				TTAAGGAGAGGAAGACGTCCT	0.448000													37	28					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33681052	33681052	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:33681052G>A	ENST00000336934.5	-	13	3183	c.3067C>T	c.(3067-3069)Ccc>Tcc	p.P1023S	STARD13_ENST00000399365.3_Missense_Mutation_p.P905S|STARD13_ENST00000255486.4_Missense_Mutation_p.P1015S	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	1023	START.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		ATTCCTTTGGGCAAATCAGTT	0.512000													18	18					0	0	1	0	0
TDRD10	126668	broad.mit.edu	37	1	154516521	154516521	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:154516521G>C	ENST00000368482.4	+	9	1424	c.586G>C	c.(586-588)Gcg>Ccg	p.A196P	TDRD10_ENST00000368480.3_Missense_Mutation_p.A196P|TDRD10_ENST00000479937.1_3'UTR	NM_001098475.1|NM_182499.3	NP_001091945.1|NP_872305.3	Q5VZ19	TDR10_HUMAN	tudor domain containing 10	196							nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCGTGGGGAGGCGGGGCTGCT	0.617000													15	102					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1568274	1568274	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:1568274G>A	ENST00000426508.2	-	30	4488	c.4125C>T	c.(4123-4125)atC>atT	p.I1375I	IFT140_ENST00000361339.5_Silent_p.I569I	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	1375										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				AGACGTCCCCGATGCGGATGG	0.597000													14	32					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65396095	65396095	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:65396095C>T	ENST00000355703.3	+	23	4271	c.3732C>T	c.(3730-3732)ttC>ttT	p.F1244F		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1244						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						AGCTGCGTTTCGTGCTGACCT	0.602000													17	19					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142622605	142622605	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:142622605C>T	ENST00000442623.1	-	8	1404	c.1141G>A	c.(1141-1143)Gga>Aga	p.G381R	TRPV5_ENST00000265310.1_Intron			Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	0					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CTCTCTCATCCCCTTCTGAGG	0.537000													6	28					0	0	1	0	0
ASB9	140462	broad.mit.edu	37	X	15266923	15266923	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:15266923G>A	ENST00000546332.1	-	7	1186	c.703C>T	c.(703-705)Cct>Tct	p.P235S	ASB9_ENST00000380488.4_Missense_Mutation_p.P235S|ASB9_ENST00000380485.3_Missense_Mutation_p.P235S|ASB9_ENST00000473862.1_5'UTR|ASB9_ENST00000380483.3_Missense_Mutation_p.P225S	NM_001168531.1	NP_001162003.1	Q96DX5	ASB9_HUMAN	ankyrin repeat and SOCS box containing 9	235					intracellular signal transduction					breast(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(10)	15	Hepatocellular(33;0.183)					AGCTCCACAGGACGTTTGCCT	0.567000													36	36					0	0	1	0	0
TFPI	7035	broad.mit.edu	37	2	188361636	188361636	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:188361636C>T	ENST00000233156.3	-	3	585	c.291G>A	c.(289-291)ctG>ctA	p.L97L	TFPI_ENST00000409676.1_Silent_p.L97L|TFPI_ENST00000339091.4_Silent_p.L97L|AC007319.1_ENST00000412276.1_RNA|TFPI_ENST00000392365.1_Silent_p.L97L|AC007319.1_ENST00000453517.1_RNA	NM_006287.4	NP_006278.1	P10646	TFPI1_HUMAN	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	97	BPTI/Kunitz inhibitor 1.				blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)	TGCACTCTTCCAGACTTTCAA	0.348000													13	23					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63064783	63064783	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:63064783G>A	ENST00000544661.1	+	4	478	c.50G>A	c.(49-51)cGa>cAa	p.R17Q	SLC22A10_ENST00000535888.1_5'UTR|SLC22A10_ENST00000332793.6_Missense_Mutation_p.R172Q|SLC22A10_ENST00000526800.1_Intron|SLC22A10_ENST00000525620.1_3'UTR			Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	172						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						AGGTTTGGGCGAAGATTTATT	0.403000													21	25					0	0	1	0	0
STOM	2040	broad.mit.edu	37	9	124111428	124111428	+	Silent	SNP	A	A	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr9:124111428A>C	ENST00000286713.2	-	5	512	c.495T>G	c.(493-495)tcT>tcG	p.S165S	STOM_ENST00000347359.2_Intron|STOM_ENST00000538954.1_Silent_p.S114S	NM_004099.4	NP_004090.4	P27105	STOM_HUMAN	stomatin	165					protein homooligomerization	cytoskeleton|integral to plasma membrane|melanosome|membrane raft	protein binding			endometrium(1)|large_intestine(1)|lung(3)|urinary_tract(1)	6				OV - Ovarian serous cystadenocarcinoma(323;0.00107)|GBM - Glioblastoma multiforme(294;0.0137)		CTTCTCTGTCAGAGAGGATCT	0.463000													14	1					0	0	1	0	0
VEGFC	7424	broad.mit.edu	37	4	177608368	177608368	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:177608368C>T	ENST00000280193.2	-	6	1533	c.1118G>A	c.(1117-1119)gGa>gAa	p.G373E	RP11-313E19.2_ENST00000504017.1_RNA|RP11-313E19.2_ENST00000509194.1_RNA	NM_005429.2	NP_005420.1	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	373					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		GAACTTCTTTCCTTTTAACAA	0.368000													51	81					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42379497	42379497	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:42379497C>T	ENST00000290472.3	-	3	350		c.e3+1			NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)						phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		CGGGCCTTCACCTTGACCTGA	0.567000													36	97					0	0	1	0	0
MRGPRX4	117196	broad.mit.edu	37	11	18195692	18195692	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:18195692G>A	ENST00000314254.3	+	1	1309	c.889G>A	c.(889-891)Gac>Aac	p.D297N	RP11-113D6.6_ENST00000527671.1_Intron	NM_054032.3	NP_473373.2	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	297						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						GGCTCTGCAGGACAAGCCTGA	0.552000													18	15					0	0	1	0	0
ALKBH7	84266	broad.mit.edu	37	19	6374516	6374516	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:6374516C>T	ENST00000245812.3	+	3	807	c.419C>T	c.(418-420)cCc>cTc	p.P140L	ALKBH7_ENST00000596657.1_5'UTR|ALKBH7_ENST00000599849.1_Missense_Mutation_p.P79L	NM_032306.3	NP_115682.1	Q9BT30	ALKB7_HUMAN	alkB, alkylation repair homolog 7 (E. coli)	140						extracellular region|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.P140R(1)		breast(2)|kidney(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						CTCCTGTCTCCCAGCGTTATG	0.652000													32	28					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185161232	185161232	+	Splice_Site	SNP	G	G	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:185161232G>C	ENST00000265026.3	+	4	993		c.e4-1		MAP3K13_ENST00000424227.1_Splice_Site|MAP3K13_ENST00000443863.1_Splice_Site|MAP3K13_ENST00000535426.1_Splice_Site|MAP3K13_ENST00000446828.1_Splice_Site	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13						activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TTTCTTGGAAGGGGTGTTTGT	0.358000													5	26					0	0	1	0	0
GSPT2	23708	broad.mit.edu	37	X	51487951	51487951	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:51487951G>A	ENST00000340438.4	+	1	1471	c.1229G>A	c.(1228-1230)gGa>gAa	p.G410E		NM_018094.4	NP_060564.2	Q8IYD1	ERF3B_HUMAN	G1 to S phase transition 2	410					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Ovarian(276;0.236)					TGGTACACTGGATTACCATTT	0.413000													25	32					0	0	1	0	0
CLIC6	54102	broad.mit.edu	37	21	36080333	36080333	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr21:36080333G>A	ENST00000360731.3	+	4	1630	c.1630G>A	c.(1630-1632)Gag>Aag	p.E544K	CLIC6_ENST00000349499.2_Missense_Mutation_p.E526K			Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	544						chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19						GAATAAGATCGAGGAGTTCTT	0.483000													15	25					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107040692	107040692	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:107040692C>T	ENST00000409886.3	-	20	3818	c.3731G>A	c.(3730-3732)gGg>gAg	p.G1244E	RGPD3_ENST00000304514.7_Missense_Mutation_p.G1244E	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1244					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TAATGTGGGCCCAGTGTTTTC	0.443000													41	171					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187510313	187510313	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:187510313G>A	ENST00000441802.2	-	27	13409	c.13200C>T	c.(13198-13200)ttC>ttT	p.F4400F		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4400					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CATAGTTGGGGAACTCTTGTA	0.488000										HNSCC(5;0.00058)			63	64					0	0	1	0	0
SERAC1	84947	broad.mit.edu	37	6	158565372	158565372	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:158565372G>A	ENST00000367102.2	-	7	709	c.568C>T	c.(568-570)Cgc>Tgc	p.R190C	SERAC1_ENST00000367101.1_Missense_Mutation_p.R190C|SERAC1_ENST00000367104.3_Missense_Mutation_p.R190C			Q96JX3	SRAC1_HUMAN	serine active site containing 1	190					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds			endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	15		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		AGAAAAAAGCGAAGATCACTC	0.328000													6	19					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	148059941	148059941	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:148059941G>A	ENST00000370460.2	+	18	4005	c.3526G>A	c.(3526-3528)Gac>Aac	p.D1176N	AFF2_ENST00000370457.5_Missense_Mutation_p.D1141N|AFF2_ENST00000342251.3_Missense_Mutation_p.D1143N|AFF2_ENST00000286437.5_Missense_Mutation_p.D817N	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	1176					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					GCTGAAGAAGGACCATGCTAT	0.353000													35	48					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40852457	40852457	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:40852457G>A	ENST00000254691.5	+	3	1222	c.1023G>A	c.(1021-1023)agG>agA	p.R341R	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	341					apoptosis|regulation of apoptosis	intracellular		p.R341S(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						TGACCGCTAGGGATTCAATCC	0.453000													7	20					0	0	1	0	0
OR5M8	219484	broad.mit.edu	37	11	56258567	56258567	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:56258567G>A	ENST00000327216.2	-	1	304	c.280C>T	c.(280-282)Cct>Tct	p.P94S		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					AGACAGGCAGGATAGGAAATG	0.463000													19	19					0	0	1	0	0
WDR44	54521	broad.mit.edu	37	X	117531026	117531026	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:117531026C>T	ENST00000254029.3	+	7	1542	c.1147C>T	c.(1147-1149)Cct>Tct	p.P383S	WDR44_ENST00000371822.5_Missense_Mutation_p.P358S|WDR44_ENST00000371825.3_Missense_Mutation_p.P383S	NM_019045.4	NP_061918.3	Q5JSH3	WDR44_HUMAN	WD repeat domain 44	383						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				breast(4)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	33						AGGCATTAATCCTCTCACTCT	0.358000													21	32					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926121	1926121	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:1926121G>A	ENST00000399161.2	-	10	2167	c.1420C>T	c.(1420-1422)Ccc>Tcc	p.P474S	MYT1L_ENST00000428368.2_Missense_Mutation_p.P474S	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	474					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCCTCCCCGGGAAGTTGTCTC	0.473000													30	21					0	0	1	0	0
DBF4B	80174	broad.mit.edu	37	17	42828497	42828497	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:42828497C>T	ENST00000315005.3	+	14	1862	c.1724C>T	c.(1723-1725)aCc>aTc	p.T575I	DBF4B_ENST00000393547.2_Intron	NM_145663.2	NP_663696.1	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B (S. cerevisiae)	575					cell cycle	nucleus	nucleic acid binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)	7		Prostate(33;0.0322)				CATCCGTGTACCCTTGCCTTC	0.562000													21	77					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171055880	171055880	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:171055880G>A	ENST00000334231.6	+	2	192	c.192G>A	c.(190-192)gtG>gtA	p.V64V	MYO3B_ENST00000409044.3_Silent_p.V55V|MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000408978.4_Silent_p.V55V			Q8WXR4	MYO3B_HUMAN	myosin IIIB	55	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						TGGCTGCAGTGAAAATTCTGG	0.393000													13	18					0	0	1	0	0
PROS1	5627	broad.mit.edu	37	3	93646166	93646166	+	Silent	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:93646166A>G	ENST00000394236.3	-	2	478	c.162T>C	c.(160-162)ctT>ctC	p.L54L	PROS1_ENST00000407433.1_5'UTR	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)	54	Gla.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	ATTCTCTTTCAAGATTACCCT	0.408000													12	20					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113277713	113277713	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:113277713C>T	ENST00000297405.5	-	60	9859	c.9615G>A	c.(9613-9615)atG>atA	p.M3205I	CSMD3_ENST00000352409.3_Missense_Mutation_p.M3135I|CSMD3_ENST00000343508.3_Missense_Mutation_p.M3165I|CSMD3_ENST00000455883.2_Missense_Mutation_p.M3036I	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3205	Sushi 24.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CATTCAATTCCATCGTGTAGC	0.418000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			41	68					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92600131	92600131	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:92600131G>A	ENST00000298047.6	+	21	11900	c.11883G>A	c.(11881-11883)ctG>ctA	p.L3961L	FAT3_ENST00000525166.1_Silent_p.L3811L|FAT3_ENST00000533797.1_Silent_p.L296L|FAT3_ENST00000409404.2_Silent_p.L3961L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3961	Laminin G-like.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCGGCGCCCTGGTGCAAGCGG	0.617000										TCGA Ovarian(4;0.039)			6	9					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74623427	74623427	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:74623427G>A	ENST00000321288.5	+	16	2260	c.2260G>A	c.(2260-2262)Gag>Aag	p.E754K	CCDC33_ENST00000558821.1_Missense_Mutation_p.E144K|CCDC33_ENST00000398814.3_Missense_Mutation_p.E551K|CCDC33_ENST00000268082.4_Missense_Mutation_p.E144K			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	754							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GAAGGCGCTGGAGGAGACTGT	0.632000													5	28					0	0	1	0	0
DOK6	220164	broad.mit.edu	37	18	67231825	67231825	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:67231825C>T	ENST00000382713.5	+	2	359	c.169C>T	c.(169-171)Cat>Tat	p.H57Y	RP11-465I4.2_ENST00000583991.1_RNA	NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	57	PH.						insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				CAGAAACTTTCATAAGGTAAG	0.408000													13	8					0	0	1	0	0
GAS2L1	10634	broad.mit.edu	37	22	29704336	29704336	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:29704336C>T	ENST00000471961.1	+	1	1289	c.241C>T	c.(241-243)Ccg>Tcg	p.P81S	GAS2L1_ENST00000341313.6_Missense_Mutation_p.P81S|GAS2L1_ENST00000360113.2_Missense_Mutation_p.P81S|GAS2L1_ENST00000406549.3_Missense_Mutation_p.P81S|GAS2L1_ENST00000407647.2_Missense_Mutation_p.P81S|GAS2L1_ENST00000403764.1_Missense_Mutation_p.P81S|GAS2L1_ENST00000407854.1_Missense_Mutation_p.P81S			Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1	81	CH.				cell cycle arrest	cytoplasm|cytoskeleton				endometrium(2)|lung(2)|prostate(1)	5						AGCCGCCCGCCCGGCCCGAGG	0.692000													13	12					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475867	120475867	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr9:120475867C>T	ENST00000355622.6	+	3	1562	c.1461C>T	c.(1459-1461)ttC>ttT	p.F487F	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Silent_p.F447F	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	487					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						AGGAAAACTTCCTTCCAGATA	0.448000													28	4					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70146232	70146232	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:70146232G>A	ENST00000335568.5	+	1	16	c.14G>A	c.(13-15)tGg>tAg	p.W5*	UGT2B28_ENST00000511240.1_Nonsense_Mutation_p.W5*	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	5					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	GCTCTGAAGTGGACTTCAGTT	0.403000													55	77					0	0	1	0	0
GPR176	11245	broad.mit.edu	37	15	40093616	40093616	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:40093616G>A	ENST00000299092.3	-	4	1460	c.1262C>T	c.(1261-1263)gCc>gTc	p.A421V	GPR176_ENST00000561100.1_Missense_Mutation_p.A422V|GPR176_ENST00000543580.1_Missense_Mutation_p.A377V	NM_001271854.1|NM_001271855.1	NP_001258783.1|NP_001258784.1	Q14439	GP176_HUMAN	G protein-coupled receptor 176	422					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)	23		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		CAGGGGTGGGGCAGAGGGCGC	0.572000													81	59					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	31201001	31201001	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:31201001G>A	ENST00000357033.4	-	68	10034	c.9828C>T	c.(9826-9828)atC>atT	p.I3276I	DMD_ENST00000378707.3_Silent_p.I816I|DMD_ENST00000359836.1_Silent_p.I816I|DMD_ENST00000378680.2_Silent_p.I208I|DMD_ENST00000474231.1_Silent_p.I816I|DMD_ENST00000378677.2_Silent_p.I3272I|DMD_ENST00000361471.4_Silent_p.I208I|DMD_ENST00000541735.1_Silent_p.I816I|DMD_ENST00000378723.3_Silent_p.I208I|DMD_ENST00000343523.2_Silent_p.I816I|DMD_ENST00000378702.4_Silent_p.I208I	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	3276	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGGCCGCTTCGATCTCTGGCT	0.527000													26	25					0	0	1	0	0
KIFC1	3833	broad.mit.edu	37	6	33374033	33374033	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:33374033G>A	ENST00000428849.2	+	8	2047	c.1597G>A	c.(1597-1599)Gaa>Aaa	p.E533K		NM_002263.3	NP_002254.2	Q9BW19	KIFC1_HUMAN	kinesin family member C1	533	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	13						AGCCCAGAATGAACGGTCATC	0.622000													57	238					0	0	1	0	0
MYB	4602	broad.mit.edu	37	6	135513668	135513668	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:135513668C>T	ENST00000341911.5	+	6	933	c.734C>T	c.(733-735)tCc>tTc	p.S245F	MYB_ENST00000527615.1_Missense_Mutation_p.S245F|MYB_ENST00000420123.2_Missense_Mutation_p.S221F|MYB_ENST00000534121.1_Missense_Mutation_p.S245F|MYB_ENST00000531845.1_3'UTR|MYB_ENST00000316528.8_Missense_Mutation_p.S245F|MYB_ENST00000528774.1_Missense_Mutation_p.S245F|MYB_ENST00000525369.1_Missense_Mutation_p.S245F|MYB_ENST00000534044.1_Missense_Mutation_p.S245F|MYB_ENST00000442647.2_Missense_Mutation_p.S245F|MYB_ENST00000533624.1_Missense_Mutation_p.S245F|MYB_ENST00000367814.4_Missense_Mutation_p.S245F	NM_001130173.1|NM_001161656.1|NM_001161658.1	NP_001123645.1|NP_001155128.1|NP_001155130.1	P10242	MYB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog	245					blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		AACGACTATTCCTATTACCAC	0.438000			T	NFIB	adenoid cystic carcinoma								8	24					0	0	1	0	0
WDR7	23335	broad.mit.edu	37	18	54339780	54339780	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:54339780C>T	ENST00000254442.3	+	2	245	c.34C>T	c.(34-36)Ctt>Ttt	p.L12F	WDR7_ENST00000589935.1_Intron|WDR7_ENST00000357574.3_Missense_Mutation_p.L12F	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	12										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		ACCCATTGTTCTTTGGGGTCG	0.408000													10	39					0	0	1	0	0
PKP3	11187	broad.mit.edu	37	11	400004	400004	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:400004G>A	ENST00000331563.2	+	6	1387	c.1311G>A	c.(1309-1311)aaG>aaA	p.K437K		NM_007183.2	NP_009114.1	Q9Y446	PKP3_HUMAN	plakophilin 3	437					cell adhesion	desmosome|nucleus	binding			breast(1)|central_nervous_system(1)|endometrium(3)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACCACCTGAAGGACCGCCTGG	0.662000													5	6					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142568095	142568095	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:142568095G>A	ENST00000392957.2	+	18	3523	c.2736G>A	c.(2734-2736)gtG>gtA	p.V912V	EPHB6_ENST00000476059.1_3'UTR|EPHB6_ENST00000411471.2_Silent_p.V635V|EPHB6_ENST00000442129.1_Silent_p.V912V	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	912	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					ACCAGCTGGTGGCTGCATTTG	0.607000													102	87					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111436534	111436534	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:111436534G>A	ENST00000265162.5	+	8	1787	c.1443_splice	c.e8-1	p.G482_splice	RP11-380D23.1_ENST00000503998.1_RNA	NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	482					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CCATTGTAGGGATCTTCTATT	0.294000													11	21					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5242240	5242240	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:5242240C>T	ENST00000274181.7	+	17	2736	c.2598C>T	c.(2596-2598)ccC>ccT	p.P866P		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	866	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						AGAAGCAGCCCCCTGCCCAGC	0.592000													38	41					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163374667	163374667	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:163374667C>T	ENST00000332142.5	-	4	564	c.463_splice	c.e4-1	p.R155_splice	KCNH7_ENST00000477019.1_5'UTR|KCNH7_ENST00000328032.4_Splice_Site_p.R155_splice	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	155					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CAAAAAATTTCCCTATAAATG	0.368000													9	13					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108868931	108868931	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:108868931C>T	ENST00000376700.1	+	2	283	c.283C>T	c.(283-285)Ccc>Tcc	p.P95S	SULT1C3_ENST00000329106.2_Missense_Mutation_p.P95S			Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	95						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						ACTGAAATTTCCCCATAAAGA	0.398000													19	26					0	0	1	0	0
CFI	3426	broad.mit.edu	37	4	110682704	110682704	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:110682704G>A	ENST00000394634.2	-	4	834	c.627C>T	c.(625-627)ttC>ttT	p.F209F	CFI_ENST00000512148.1_Silent_p.F209F|CFI_ENST00000394635.3_Silent_p.F209F	NM_000204.3	NP_000195.2	P05156	CFAI_HUMAN	complement factor I	209	SRCR.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity	p.F209F(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|skin(2)|stomach(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		CCACATCAGCGAAATCCTGGT	0.393000													27	49					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54791158	54791158	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:54791158G>A	ENST00000293379.4	-	29	3318	c.3057C>T	c.(3055-3057)atC>atT	p.I1019I	RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	1019					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						CCTTGTAGAGGATGTAGATGA	0.542000													7	27					0	0	1	0	0
GBP1P1	400759	broad.mit.edu	37	1	89889902	89889902	+	RNA	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:89889902G>A	ENST00000513638.1	+	0	643					NR_003133.2																						TGATGGAACAGAAGGAGAGGA	0.473000													91	309					0	0	1	0	0
ZNF75D	7626	broad.mit.edu	37	X	134427838	134427838	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:134427838A>G	ENST00000370766.3	-	3	2938	c.229T>C	c.(229-231)Tgg>Cgg	p.W77R	ZNF75D_ENST00000370764.1_Missense_Mutation_p.W77R|ZNF75D_ENST00000494295.1_Intron	NM_007131.3	NP_009062.2	P51815	ZN75D_HUMAN	zinc finger protein 75D	77	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						GGCCTCAGCCACTGATGGCAC	0.522000													28	38					0	0	1	0	0
PRSS1	5644	broad.mit.edu	37	7	142458485	142458485	+	Silent	SNP	C	C	T	rs145133152	by1000genomes	TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:142458485C>T	ENST00000486171.1	+	2	137	c.120C>T	c.(118-120)tcC>tcT	p.S40S	PRSS1_ENST00000311737.7_Silent_p.S40S			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	40	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			ACCAGGTGTCCCTGAATTCTG	0.557000													5	114					0	0	1	0	0
CTBP2	1488	broad.mit.edu	37	10	126716208	126716208	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:126716208G>A	ENST00000309035.6	-	1	251	c.121C>T	c.(121-123)Ctg>Ttg	p.L41L	CTBP2_ENST00000411419.2_Intron|CTBP2_ENST00000337195.5_Intron|CTBP2_ENST00000531469.1_Intron|CTBP2_ENST00000494626.2_Intron	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	0					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CCATACGTCAGGGAGCTTCTC	0.637000													22	4					0	0	1	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140762958	140762958	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:140762958G>A	ENST00000518325.1	+	1	492	c.492G>A	c.(490-492)acG>acA	p.T164T	PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTGGGCACGAACTCCCTCC	0.512000													17	3					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92301426	92301426	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:92301426C>T	ENST00000276609.3	+	3	495	c.256C>T	c.(256-258)Cct>Tct	p.P86S	SLC26A7_ENST00000309536.2_Missense_Mutation_p.P86S|SLC26A7_ENST00000523719.1_Missense_Mutation_p.P86S	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	86						basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			GTCTCTGTTTCCTGCCATAAT	0.383000													43	40					0	0	1	0	0
IQUB	154865	broad.mit.edu	37	7	123152300	123152300	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:123152300G>A	ENST00000466202.1	-	2	671	c.95C>T	c.(94-96)cCc>cTc	p.P32L	IQUB_ENST00000488987.1_Intron|IQUB_ENST00000324698.6_Missense_Mutation_p.P32L|IQUB_ENST00000434450.1_Missense_Mutation_p.P32L			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	32										breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						CTCTTCTGAGGGAACTGGAAT	0.403000													19	39					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13941282	13941282	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:13941282G>A	ENST00000254323.2	+	13	2577	c.2388G>A	c.(2386-2388)gcG>gcA	p.A796A	ZSWIM4_ENST00000440752.2_Silent_p.A630A	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	796							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			TGGACGCGGCGGCCGGCGGCC	0.697000													64	75					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27106252	27106252	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:27106252C>T	ENST00000324856.7	+	20	6234	c.5863C>T	c.(5863-5865)Cta>Tta	p.L1955L	ARID1A_ENST00000457599.2_Silent_p.L1738L|ARID1A_ENST00000540690.1_Silent_p.L283L|ARID1A_ENST00000374152.2_Silent_p.L1572L	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1955					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CATCAAGATCCTAGAGGACGA	0.532000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								69	39					0	0	1	0	0
ISX	91464	broad.mit.edu	37	22	35480375	35480375	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:35480375G>A	ENST00000308700.6	+	3	1333		c.e3-1		ISX_ENST00000404699.2_Splice_Site	NM_001008494.1	NP_001008494.1	Q2M1V0	ISX_HUMAN	intestine-specific homeobox							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(12)|ovary(3)|prostate(1)|skin(4)	26						CCTGATTACAGATCTGGTTCC	0.517000													15	14					0	0	1	0	0
IFT46	56912	broad.mit.edu	37	11	118425227	118425227	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:118425227G>A	ENST00000264020.2	-	8	960	c.583C>T	c.(583-585)Cct>Tct	p.P195S	IFT46_ENST00000530872.1_Missense_Mutation_p.P195S|IFT46_ENST00000264021.3_Missense_Mutation_p.P144S	NM_020153.3	NP_064538.3	Q9NQC8	IFT46_HUMAN	intraflagellar transport 46 homolog (Chlamydomonas)	144					flagellum assembly|intraflagellar transport|protein stabilization	microtubule basal body|microtubule-based flagellum|nucleus	protein C-terminus binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9						AGCACCGTAGGGTCTGACTGC	0.473000													14	17					0	0	1	0	0
LCA5	167691	broad.mit.edu	37	6	80228502	80228502	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:80228502G>A	ENST00000392959.1	-	3	721	c.110C>T	c.(109-111)tCg>tTg	p.S37L	LCA5_ENST00000369846.4_Missense_Mutation_p.S37L|LCA5_ENST00000467898.2_Missense_Mutation_p.S37L	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	37					protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		ACTGACCAGCGATGATCGGCC	0.418000													34	49					0	0	1	0	0
MLIP	90523	broad.mit.edu	37	6	54025387	54025387	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:54025387C>T	ENST00000514921.1	+	7	2509	c.2396C>T	c.(2395-2397)tCc>tTc	p.S799F	MLIP_ENST00000274897.5_Missense_Mutation_p.S275F|MLIP_ENST00000502396.1_Missense_Mutation_p.S810F|MLIP_ENST00000509997.1_Intron|MLIP_ENST00000370876.2_Intron|MLIP_ENST00000370877.2_Intron|MLIP_ENST00000358276.5_Intron|MLIP_ENST00000511744.1_3'UTR			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	275						nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						TTACAGGATTCCTTGTCTATG	0.418000													6	7					0	0	1	0	0
WDR75	84128	broad.mit.edu	37	2	190332266	190332266	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:190332266C>T	ENST00000314761.4	+	14	1580	c.1520C>T	c.(1519-1521)tCc>tTc	p.S507F		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	507						nucleolus				breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			TGTTGTTTCTCCGAAGATGGT	0.388000													42	54					0	0	1	0	0
RETNLB	84666	broad.mit.edu	37	3	108475975	108475975	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:108475975G>A	ENST00000295755.6	-	1	256	c.58C>T	c.(58-60)Ccg>Tcg	p.P20S		NM_032579.2	NP_115968.1	Q9BQ08	RETNB_HUMAN	resistin like beta	20			P -> L (in dbSNP:rs11708527).		cell proliferation	extracellular region	hormone activity			endometrium(1)|kidney(3)|lung(10)|prostate(1)|skin(1)	16						GTACTCCCCGGGTTGATCAGC	0.532000													7	15					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66204834	66204834	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:66204834G>A	ENST00000503581.1	-	4	1007	c.470C>T	c.(469-471)tCa>tTa	p.S157L	EYS_ENST00000342421.5_Missense_Mutation_p.S157L|EYS_ENST00000370616.2_Missense_Mutation_p.S157L|EYS_ENST00000370618.3_Missense_Mutation_p.S157L|EYS_ENST00000393380.2_Missense_Mutation_p.S157L|EYS_ENST00000370621.3_Missense_Mutation_p.S157L	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	157					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						TGGACAAGGTGATGGACCACT	0.418000													11	12					0	0	1	0	0
PHLDB3	653583	broad.mit.edu	37	19	43998885	43998885	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:43998885G>A	ENST00000292140.5	-	9	1478	c.1118C>T	c.(1117-1119)tCc>tTc	p.S373F		NM_198850.3	NP_942147.3	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B, member 3	373										breast(1)|central_nervous_system(1)|lung(5)	7		Prostate(69;0.0153)				AAAGAGGCAGGAAGAAGTAGG	0.597000													11	5					0	0	1	0	0
ARSH	347527	broad.mit.edu	37	X	2951235	2951235	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:2951235G>A	ENST00000381130.2	+	9	1498	c.1498G>A	c.(1498-1500)Gag>Aag	p.E500K		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	500						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CCCTGACAATGAGCCATTATT	0.483000													9	11					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59157994	59157994	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:59157994G>A	ENST00000262717.4	+	2	606	c.208G>A	c.(208-210)Gaa>Aaa	p.E70K	CDH20_ENST00000536675.2_Missense_Mutation_p.E70K|CDH20_ENST00000538374.1_Missense_Mutation_p.E70K			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	70	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				TTTCGTTCTGGAAGAGTACAC	0.463000													31	40					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75893175	75893175	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:75893175C>T	ENST00000322507.8	-	10	1791	c.1482G>A	c.(1480-1482)ttG>ttA	p.L494L	COL12A1_ENST00000416123.2_Silent_p.L494L|COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000483888.2_Silent_p.L494L	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	494	VWFA 2.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TGAATTTTTTCAAAGTGAACT	0.368000													15	18					0	0	1	0	0
TMEM255B	348013	broad.mit.edu	37	13	114504661	114504661	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:114504661G>C	ENST00000375353.3	+	7	572	c.545G>C	c.(544-546)gGc>gCc	p.G182A		NM_182614.2	NP_872420.1			transmembrane protein 255B																		GAGTTCATCGGCGTCAGCGGC	0.637000													5	17					0	0	1	0	0
OR9Q1	219956	broad.mit.edu	37	11	57946956	57946956	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:57946956C>T	ENST00000335397.3	+	3	356	c.40C>T	c.(40-42)Ctt>Ttt	p.L14F		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				CGAGTTCCTCCTTATTGCATT	0.438000													16	25					0	0	1	0	0
PLK3	1263	broad.mit.edu	37	1	45267295	45267295	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:45267295C>T	ENST00000372201.4	+	4	676	c.435_splice	c.e4-1	p.S146_splice	PLK3_ENST00000465443.1_3'UTR	NM_004073.2	NP_004064.2	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	146	Protein kinase.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					TCTCTGCAGTCCCTGGCCCAC	0.637000													6	35					0	0	1	0	0
PRR3	80742	broad.mit.edu	37	6	30529767	30529767	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:30529767C>T	ENST00000376560.3	+	3	785	c.326C>T	c.(325-327)cCt>cTt	p.P109L	PRR3_ENST00000376557.3_Missense_Mutation_p.P88L|PRR3_ENST00000498336.1_3'UTR	NM_025263.3	NP_079539.2	P79522	PRR3_HUMAN	proline rich 3	109	Pro-rich.						nucleic acid binding|zinc ion binding			lung(1)|ovary(1)	2						GCAGAACCTCCTTTTCCGGGG	0.577000													35	11					0	0	1	0	0
ABRA	137735	broad.mit.edu	37	8	107781836	107781836	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:107781836C>T	ENST00000311955.3	-	1	637	c.583G>A	c.(583-585)Ggc>Agc	p.G195S		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	195					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			CCTCCATAGCCGCTGTCCTCT	0.582000													154	124					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43926706	43926706	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:43926706C>T	ENST00000262726.7	-	31	4625	c.4372G>A	c.(4372-4374)Gat>Aat	p.D1458N	EFCAB6_ENST00000461800.1_5'UTR|EFCAB6_ENST00000396231.2_Missense_Mutation_p.D1306N|EFCAB6-AS1_ENST00000431327.2_RNA	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1458	EF-hand 16.|Interaction with AR.|Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				GTCCTGAAATCTGCGACGCTT	0.592000													31	40					0	0	1	0	0
RNF180	285671	broad.mit.edu	37	5	63496695	63496695	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:63496695C>T	ENST00000389100.4	+	2	133	c.61C>T	c.(61-63)Cgt>Tgt	p.R21C	RNF180_ENST00000381081.2_Missense_Mutation_p.R21C|RNF180_ENST00000296615.6_Missense_Mutation_p.R21C	NM_001113561.1	NP_001107033.1	Q86T96	RN180_HUMAN	ring finger protein 180	21				SILRC -> GETVFSL (in Ref. 2; CAD89939).		integral to membrane|nuclear envelope	zinc ion binding			breast(1)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	20		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		AAGTATTCTTCGTTGTTGGAA	0.333000													19	23					0	0	1	0	0
MAOA	4128	broad.mit.edu	37	X	43571159	43571159	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:43571159G>A	ENST00000338702.3	+	4	470	c.347G>A	c.(346-348)tGg>tAg	p.W116*	MAOA_ENST00000542639.1_5'UTR|MAOA_ENST00000497485.1_3'UTR	NM_000240.3	NP_000231.1	P21397	AOFA_HUMAN	monoamine oxidase A	116					behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	18					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	CCACCAGTATGGAATCCCATT	0.378000													16	61					0	0	1	0	0
ABCC4	10257	broad.mit.edu	37	13	95829962	95829962	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:95829962G>A	ENST00000376887.4	-	13	1840	c.1727_splice	c.e13+1	p.L576_splice	ABCC4_ENST00000538287.1_3'UTR|ABCC4_ENST00000536256.1_Splice_Site_p.L501_splice|ABCC4_ENST00000431522.1_Splice_Site_p.L576_splice|ABCC4_ENST00000412704.1_Splice_Site_p.L576_splice	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	576	ABC transporter 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	CACACTCACAGTTCGAACAAG	0.448000													5	18					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19744834	19744834	+	Silent	SNP	G	G	A	rs138372356		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:19744834G>A	ENST00000203556.4	-	19	2387	c.2250C>T	c.(2248-2250)atC>atT	p.I750I	GMIP_ENST00000445806.2_Silent_p.I721I|GMIP_ENST00000587238.1_Silent_p.I724I	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	750	Rho-GAP.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CGTAGTGCACGATGAGGAACT	0.682000													25	35					0	0	1	0	0
ZNF41	7592	broad.mit.edu	37	X	47307368	47307368	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:47307368G>A	ENST00000377065.4	-	5	2440	c.1801C>T	c.(1801-1803)Cat>Tat	p.H601Y	ZNF41_ENST00000313116.7_Missense_Mutation_p.H601Y|ZNF41_ENST00000397050.2_Missense_Mutation_p.H611Y	NM_153380.2	NP_700359.1	P51814	ZNF41_HUMAN	zinc finger protein 41	643						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|upper_aerodigestive_tract(2)	24		all_lung(315;0.000129)				TCTCCTGTATGGATTCTCTGA	0.448000													17	27					0	0	1	0	0
NDUFAF1	51103	broad.mit.edu	37	15	41679741	41679741	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:41679741G>A	ENST00000260361.4	-	5	1266	c.885C>T	c.(883-885)ttC>ttT	p.F295F		NM_016013.3	NP_057097.2	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1	295					mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	12		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)		CTATCTCCAGGAAGAATGGAC	0.348000													23	25					0	0	1	0	0
DHDH	27294	broad.mit.edu	37	19	49442759	49442759	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:49442759C>T	ENST00000221403.2	+	4	460	c.420C>T	c.(418-420)gcC>gcT	p.A140A	DHDH_ENST00000522614.1_Silent_p.A140A|DHDH_ENST00000523250.1_Intron	NM_014475.3	NP_055290.1	Q9UQ10	DHDH_HUMAN	dihydrodiol dehydrogenase (dimeric)	140					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			central_nervous_system(1)|large_intestine(3)|lung(3)|ovary(1)|soft_tissue(1)	9		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		CTGTTTTGGCCCAGGGAACTC	0.607000													14	50					0	0	1	0	0
CLEC18B	497190	broad.mit.edu	37	16	74443752	74443752	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:74443752C>T	ENST00000339953.5	-	11	1357	c.1236G>A	c.(1234-1236)atG>atA	p.M412I		NM_001011880.2	NP_001011880.2	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	412	C-type lectin.					extracellular region	sugar binding			endometrium(3)|kidney(9)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						CTGCCTACCCCATGGCAGCAC	0.637000													5	47					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47686167	47686167	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:47686167C>T	ENST00000283303.2	+	9	2335	c.2077C>T	c.(2077-2079)Cgt>Tgt	p.R693C	GPR115_ENST00000371220.1_Missense_Mutation_p.R750C|GPR115_ENST00000327753.3_Missense_Mutation_p.R693C	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	693					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						ATTAATGAATCGTCAAGGATG	0.348000													19	15					0	0	1	0	0
ADAM7	8756	broad.mit.edu	37	8	24359010	24359010	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:24359010G>A	ENST00000175238.6	+	20	2212	c.2129G>A	c.(2128-2130)gGa>gAa	p.G710E	ADAM7_ENST00000520720.1_Missense_Mutation_p.G482E|RP11-624C23.1_ENST00000519689.1_RNA|ADAM7_ENST00000380789.1_Missense_Mutation_p.G710E|RP11-624C23.1_ENST00000523578.1_RNA|RP11-561E1.1_ENST00000519364.1_RNA	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	710					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding	p.G710E(1)		NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		GAAACCCTGGGAGTGGAGAAC	0.378000													9	30					0	0	1	0	0
OR4N5	390437	broad.mit.edu	37	14	20612188	20612188	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:20612188C>T	ENST00000333629.1	+	1	294	c.294C>T	c.(292-294)atC>atT	p.I98I		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I98I(1)		endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		GAAGCTGCATCACTCAGCTCT	0.493000													51	9					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203015104	203015104	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:203015104C>T	ENST00000367240.2	+	8	1521	c.994C>T	c.(994-996)Ctg>Ttg	p.L332L	PPFIA4_ENST00000414050.2_Silent_p.L39L|PPFIA4_ENST00000447715.2_Silent_p.L332L|PPFIA4_ENST00000295706.4_5'UTR			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	260					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						CAAGGAGTCCCTGCACCGCCA	0.582000													67	93					0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1074872	1074872	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:1074872G>A	ENST00000313093.2	+	10	1410	c.1179G>A	c.(1177-1179)agG>agA	p.R393R	HMHA1_ENST00000586866.1_Silent_p.R397R|HMHA1_ENST00000536472.1_Silent_p.R233R|HMHA1_ENST00000590214.1_Silent_p.R420R|HMHA1_ENST00000539243.2_Silent_p.R409R|HMHA1_ENST00000543365.1_Silent_p.R276R	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	393					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGCCCAGAGGAAGCTGGTGA	0.761000													3	4					0	0	1	0	0
FANCB	2187	broad.mit.edu	37	X	14883544	14883544	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:14883544C>T	ENST00000398334.1	-	3	356	c.89G>A	c.(88-90)gGa>gAa	p.G30E	FANCB_ENST00000324138.3_Missense_Mutation_p.G30E	NM_001018113.1	NP_001018123.1	Q8NB91	FANCB_HUMAN	Fanconi anemia, complementation group B	30					DNA repair	nucleoplasm				NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24	Hepatocellular(33;0.183)					TGCAAAATTTCCTTTAGACAA	0.368000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				14	74					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82451874	82451874	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:82451874C>T	ENST00000423517.2	-	20	15065	c.14728G>A	c.(14728-14730)Gaa>Aaa	p.E4910K	PCLO_ENST00000426442.2_5'UTR|PCLO_ENST00000333891.8_Missense_Mutation_p.E4910K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4772					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CCTGCATCTTCCAGGTGGGTC	0.507000													34	173					0	0	1	0	0
ZC4H2	55906	broad.mit.edu	37	X	64140043	64140043	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:64140043C>T	ENST00000545618.1	-	4	864	c.301G>A	c.(301-303)Gaa>Aaa	p.E101K	ZC4H2_ENST00000374839.3_Missense_Mutation_p.E106K|ZC4H2_ENST00000447788.2_Missense_Mutation_p.E106K|ZC4H2_ENST00000488608.1_5'UTR|ZC4H2_ENST00000337990.2_Missense_Mutation_p.E83K			Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	106							metal ion binding|protein binding	p.E106*(1)		endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						TCCACATGTTCTTTCAGTGGC	0.483000													41	41					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154595636	154595636	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:154595636C>T	ENST00000404039.1	+	14	1865	c.1278C>T	c.(1276-1278)atC>atT	p.I426I	DPP6_ENST00000332007.3_Silent_p.I428I|DPP6_ENST00000377770.3_Silent_p.I490I|DPP6_ENST00000427557.1_Silent_p.I383I	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	490					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TGACCAAGATCCTAGCCTACG	0.522000													14	6					0	0	1	0	0
C1QTNF2	114898	broad.mit.edu	37	5	159776435	159776435	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:159776435C>T	ENST00000393975.3	-	3	736	c.733G>A	c.(733-735)Gac>Aac	p.D245N		NM_031908.4	NP_114114.2	Q9BXJ5	C1QT2_HUMAN	C1q and tumor necrosis factor related protein 2	200	C1q.					collagen				breast(2)|endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	13	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGCGTGATGTCGTAGGTGAAG	0.572000													29	8					0	0	1	0	0
TFR2	7036	broad.mit.edu	37	7	100238652	100238652	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:100238652C>T	ENST00000462107.1	-	3	520	c.233G>A	c.(232-234)gGa>gAa	p.G78E	TFR2_ENST00000223051.3_Missense_Mutation_p.G78E|TFR2_ENST00000431692.1_Missense_Mutation_p.G78E			Q9UP52	TFR2_HUMAN	transferrin receptor 2	78					cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					AGCCCTCCGTCCTGCTGCCGC	0.677000													3	25					0	0	1	0	0
TEKT3	64518	broad.mit.edu	37	17	15231335	15231335	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:15231335C>T	ENST00000395930.1	-	4	823	c.637G>A	c.(637-639)Gat>Aat	p.D213N	TEKT3_ENST00000338696.2_Missense_Mutation_p.D213N	NM_031898.2	NP_114104.1	Q9BXF9	TEKT3_HUMAN	tektin 3	213					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				endometrium(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	23				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		TCAACTTCATCGTGAACTAGG	0.393000													16	41					0	0	1	0	0
DIAPH3	81624	broad.mit.edu	37	13	60435628	60435628	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:60435628G>A	ENST00000400324.4	-	22	2870	c.2650C>T	c.(2650-2652)Cat>Tat	p.H884Y	DIAPH3_ENST00000400319.1_Missense_Mutation_p.H814Y|DIAPH3_ENST00000400320.1_Missense_Mutation_p.H838Y|DIAPH3_ENST00000400330.1_Missense_Mutation_p.H884Y|DIAPH3_ENST00000377908.2_Missense_Mutation_p.H873Y|DIAPH3_ENST00000267215.4_Missense_Mutation_p.H884Y|DIAPH3_ENST00000465066.1_5'UTR	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	884	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		ACCAGGAAATGAAGTAGCGTT	0.358000													9	31					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121358839	121358839	+	Silent	SNP	C	C	T	rs144880203		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:121358839C>T	ENST00000260197.7	+	4	756	c.627C>T	c.(625-627)ctC>ctT	p.L209L	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	209					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity	p.L209L(1)		NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CAGCTGATCTCCTCCTACACA	0.522000													30	58					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144994716	144994716	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:144994716G>A	ENST00000369356.4	-	1	306	c.16C>T	c.(16-18)Cgc>Tgc	p.R6C	PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000369347.4_Missense_Mutation_p.R6C|PDE4DIP_ENST00000369348.3_Intron|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.R6C|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.R6C|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.R6C|PDE4DIP_ENST00000369359.4_Intron	NM_001198834.2|NM_014644.4	NP_001185763.2|NP_055459.4	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	6					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GACAGAGTGCGATATCCATTA	0.567000			T	PDGFRB	MPD								9	84					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94841723	94841723	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:94841723T>C	ENST00000357742.4	+	1	229	c.229T>C	c.(229-231)Tcg>Ccg	p.S77P	MCTP2_ENST00000331706.4_5'UTR|MCTP2_ENST00000543482.1_Missense_Mutation_p.S77P|MCTP2_ENST00000451018.3_Missense_Mutation_p.S77P	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	77					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TTCCTACACCTCGGTGCCCAG	0.592000													12	36					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887382	12887382	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:12887382G>A	ENST00000535591.1	-	3	670	c.475C>T	c.(475-477)Ctg>Ttg	p.L159L		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	159								p.L159M(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						ACCATTTTCAGGATGCTTCTG	0.478000													51	156					0	0	1	0	0
SNRPB	6628	broad.mit.edu	37	20	2444465	2444465	+	Silent	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr20:2444465A>G	ENST00000339610.6	-	5	566	c.111T>C	c.(109-111)gcT>gcC	p.A37A	SNRPB_ENST00000381342.2_Silent_p.A116A|SNRPB_ENST00000438552.2_Silent_p.A116A			P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptides B and B1	116					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	10						TGGGAACCCCAGCTGGGATTC	0.607000													69	85					0	0	1	0	0
KCNA10	3744	broad.mit.edu	37	1	111060342	111060342	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:111060342G>A	ENST00000369771.2	-	1	1455	c.1068C>T	c.(1066-1068)cgC>cgT	p.R356R		NM_005549.2	NP_005540.1	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 10	356						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(3)|skin(1)|urinary_tract(1)	35		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		CCTTGGAGTGGCGCGAGAGCT	0.567000													67	43					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163075597	163075597	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:163075597C>T	ENST00000188790.4	-	8	790	c.583G>A	c.(583-585)Gga>Aga	p.G195R	FAP_ENST00000443424.1_Missense_Mutation_p.G170R	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	195					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity	p.G195R(1)		NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						TCTGGGATTCCATTAAATATT	0.279000													16	19					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137376	40137376	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:40137376C>T	ENST00000278198.2	-	2	2430	c.467G>A	c.(466-468)cGa>cAa	p.R156Q	LRRC4C_ENST00000530763.1_Missense_Mutation_p.R156Q|LRRC4C_ENST00000528697.1_Missense_Mutation_p.R156Q|LRRC4C_ENST00000527150.1_Missense_Mutation_p.R156Q			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	156					regulation of axonogenesis	integral to membrane	protein binding	p.R156Q(2)		NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GGGGTTGTTTCGCAACCAGAG	0.428000													8	16					0	0	1	0	0
TWSG1	57045	broad.mit.edu	37	18	9396355	9396355	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:9396355C>T	ENST00000262120.5	+	4	492	c.301C>T	c.(301-303)Cct>Tct	p.P101S	TWSG1_ENST00000581641.1_Missense_Mutation_p.P101S	NM_020648.5	NP_065699.1	Q9GZX9	TWSG1_HUMAN	twisted gastrulation BMP signaling modulator 1	101								p.I100fs*10(1)		breast(1)|endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|pancreas(2)	10						TGAACCGATCCCTTCTCTCTT	0.448000													18	46					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153594725	153594725	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:153594725G>A	ENST00000422373.1	-	8	1427	c.1179C>T	c.(1177-1179)ccC>ccT	p.P393P	FLNA_ENST00000360319.4_Silent_p.P393P|FLNA_ENST00000369850.3_Silent_p.P393P|FLNA_ENST00000344736.4_Silent_p.P393P	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	393					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGTTGCCACTGGGCTCCAGGC	0.612000													25	46					0	0	1	0	0
HSD17B6	8630	broad.mit.edu	37	12	57167846	57167846	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:57167846G>A	ENST00000554643.1	+	3	559	c.210G>A	c.(208-210)agG>agA	p.R70R	HSD17B6_ENST00000555805.1_Silent_p.R70R|HSD17B6_ENST00000555159.1_Silent_p.R70R|HSD17B6_ENST00000554150.1_Silent_p.R70R|HSD17B6_ENST00000322165.1_Silent_p.R70R			O14756	H17B6_HUMAN	hydroxysteroid (17-beta) dehydrogenase 6	70					androgen biosynthetic process|androgen catabolic process	early endosome membrane|endoplasmic reticulum|microsome	binding|electron carrier activity|estradiol 17-beta-dehydrogenase activity|retinol dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			endometrium(1)|large_intestine(2)|lung(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10					Succinic acid(DB00139)	AGCAGCTGAGGGGCCAGACGT	0.617000													23	20					0	0	1	0	0
TLE6	79816	broad.mit.edu	37	19	2987189	2987189	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:2987189G>A	ENST00000246112.4	+	7	695	c.494G>A	c.(493-495)cGg>cAg	p.R165Q	TLE6_ENST00000478073.2_3'UTR|TLE6_ENST00000452088.1_Missense_Mutation_p.R42Q	NM_001143986.1	NP_001137458.1	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)	42					regulation of transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAACTCTGGCGGATTTTTGCC	0.622000													54	60					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92734188	92734188	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:92734188G>A	ENST00000379958.2	-	3	1492	c.1223C>T	c.(1222-1224)tCa>tTa	p.S408L		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	408						cytoplasm		p.S408L(1)		NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TTCATAGTATGAATTATCTAA	0.318000													13	28					0	0	1	0	0
CCL2	6347	broad.mit.edu	37	17	32583799	32583799	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:32583799G>A	ENST00000225831.4	+	3	318	c.253G>A	c.(253-255)Gat>Aat	p.D85N	CCL2_ENST00000580907.1_3'UTR	NM_002982.3	NP_002973.1	P13500	CCL2_HUMAN	chemokine (C-C motif) ligand 2	85					angiogenesis|anti-apoptosis|apoptotic cell clearance|astrocyte cell migration|cell adhesion|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|G-protein signaling, coupled to cyclic nucleotide second messenger|helper T cell extravasation|humoral immune response|inflammatory response|JAK-STAT cascade|macrophage chemotaxis|monocyte chemotaxis|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of T cell activation|viral genome replication	extracellular space	CCR2 chemokine receptor binding|chemokine activity|protein kinase activity|signal transducer activity			kidney(1)|lung(3)|pancreas(1)|upper_aerodigestive_tract(1)	6	Breast(3;0.00224)	Ovarian(249;0.0694)|Breast(31;0.151)|Lung NSC(157;0.153)		UCEC - Uterine corpus endometrioid carcinoma (308;0.000241)|BRCA - Breast invasive adenocarcinoma(366;0.0103)	Atorvastatin(DB01076)|Danazol(DB01406)|Mimosine(DB01055)|Simvastatin(DB00641)	GTGGGTTCAGGATTCCATGGA	0.498000													9	22					0	0	1	0	0
TNP2	7142	broad.mit.edu	37	16	11362868	11362868	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:11362868C>T	ENST00000312693.3	-	1	321	c.252G>A	c.(250-252)aaG>aaA	p.K84K	RMI2_ENST00000572173.1_Intron	NM_005425.4	NP_005416.1	Q05952	STP2_HUMAN	transition protein 2 (during histone to protamine replacement)	84					cell differentiation|multicellular organismal development|spermatogenesis	nucleosome|nucleus	DNA binding	p.0?(1)		large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	6						AGTTCATAGTCTTTTTGTGGC	0.567000													46	65					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156639980	156639980	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:156639980G>A	ENST00000368223.3	-	4	4132	c.4000C>T	c.(4000-4002)Cct>Tct	p.P1334S		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1334	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGGACAGCAGGATCCCAGCCC	0.652000													52	61					0	0	1	0	0
VPS35	55737	broad.mit.edu	37	16	46706386	46706386	+	Splice_Site	SNP	T	T	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:46706386T>A	ENST00000299138.7	-	11	1219		c.e11-2		VPS35_ENST00000568642.1_Splice_Site	NM_018206.4	NP_060676.2	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35 homolog (S. cerevisiae)						protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|pancreas(1)|prostate(1)|urinary_tract(1)	23		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GTAGCAATACTACAAAAAGAA	0.269000													19	22					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12734464	12734464	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:12734464C>T	ENST00000380682.1	+	15	2392	c.1886C>T	c.(1885-1887)tCc>tTc	p.S629F		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	629					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						GCTCAGCGGTCCCTATTGACC	0.507000													43	61					0	0	1	0	0
STK10	6793	broad.mit.edu	37	5	171544499	171544499	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:171544499C>T	ENST00000176763.5	-	4	849	c.506G>A	c.(505-507)gGa>gAa	p.G169E		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	169	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCTGATGTCTCCCTCGAGGGT	0.607000													11	36					0	0	1	0	0
WDR66	144406	broad.mit.edu	37	12	122398590	122398590	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:122398590C>T	ENST00000288912.4	+	14	3087	c.2233C>T	c.(2233-2235)Cga>Tga	p.R745*	WDR66_ENST00000397454.2_Nonsense_Mutation_p.R745*	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	745							calcium ion binding	p.R745*(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		CAAAAGCATTCGAAGTCTCCT	0.488000													37	4					0	0	1	0	0
TRIM15	89870	broad.mit.edu	37	6	30137031	30137031	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:30137031A>G	ENST00000376694.4	+	4	1191	c.722A>G	c.(721-723)aAc>aGc	p.N241S	TRIM15_ENST00000376688.1_Intron	NM_033229.2	NP_150232.2	Q9C019	TRI15_HUMAN	tripartite motif containing 15	241					mesodermal cell fate determination	intracellular	zinc ion binding			large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	14						GTCAGAGTCAACCAGAGCAGG	0.478000													11	17					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106845891	106845891	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:106845891C>T	ENST00000276185.4	+	16	4721	c.4721C>T	c.(4720-4722)aCc>aTc	p.T1574I				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	1574						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						GTGAGCAGGACCCTGCAGGTG	0.612000													23	32					0	0	1	0	0
PCSK9	255738	broad.mit.edu	37	1	55509519	55509519	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:55509519C>T	ENST00000302118.5	+	2	501	c.211C>T	c.(211-213)Ccg>Tcg	p.P71S	PCSK9_ENST00000452118.2_Missense_Mutation_p.P71S|PCSK9_ENST00000543384.1_Intron	NM_174936.3	NP_777596.2	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	71					cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(1)|liver(2)|lung(4)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	32						GGGCCAGGATCCGTGGAGGTT	0.572000													36	8					0	0	1	0	0
PTPN21	11099	broad.mit.edu	37	14	88935351	88935351	+	Missense_Mutation	SNP	G	G	A	rs150736820	byFrequency	TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:88935351G>A	ENST00000556564.1	-	18	3589	c.3305C>T	c.(3304-3306)cCt>cTt	p.P1102L	PTPN21_ENST00000328736.3_Missense_Mutation_p.P1102L	NM_007039.3	NP_008970.2	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type 21	1102	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|liver(1)|lung(7)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						CAACAACGGAGGGTTGGGGCT	0.493000													19	1					0	0	1	0	0
BPIFA2	140683	broad.mit.edu	37	20	31760783	31760783	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr20:31760783C>T	ENST00000253362.2	+	3	349	c.203C>T	c.(202-204)tCc>tTc	p.S68F	BPIFA2_ENST00000354932.5_Missense_Mutation_p.S68F			Q96DR5	SPLC2_HUMAN	BPI fold containing family A, member 2	68						extracellular region	lipid binding										CTTCAGAAATCCAGTGCTTGG	0.473000													6	26					0	0	1	0	0
ZNF404	342908	broad.mit.edu	37	19	44377519	44377519	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:44377519G>A	ENST00000587539.1	-	3	846	c.847C>T	c.(847-849)Cgt>Tgt	p.R283C	ZNF404_ENST00000324394.6_Missense_Mutation_p.R281C	NM_001033719.2	NP_001028891.2	Q494X3	ZN404_HUMAN	zinc finger protein 404	283					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|skin(1)|stomach(2)|urinary_tract(1)	17		Prostate(69;0.0352)				AGACTTGAACGATGACCAAAA	0.358000													7	1					0	0	1	0	0
FLAD1	80308	broad.mit.edu	37	1	154962153	154962153	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:154962153T>C	ENST00000368433.1	+	3	1578	c.1235T>C	c.(1234-1236)cTc>cCc	p.L412P	FLAD1_ENST00000295530.2_Intron|FLAD1_ENST00000405236.2_Intron|FLAD1_ENST00000315144.10_Missense_Mutation_p.L315P|FLAD1_ENST00000368432.1_Missense_Mutation_p.L315P|FLAD1_ENST00000292180.3_Missense_Mutation_p.L412P|FLAD1_ENST00000368428.1_5'UTR			Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase 1	412	FAD synthase.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|ovary(3)|skin(3)	22	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TGCACTGCCCTCCTGCACCTC	0.592000													36	45					0	0	1	0	0
TNFRSF10B	8795	broad.mit.edu	37	8	22884668	22884668	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:22884668G>A	ENST00000276431.4	-	7	1198	c.914C>T	c.(913-915)cCc>cTc	p.P305L	TNFRSF10B_ENST00000347739.3_Missense_Mutation_p.P276L|TNFRSF10B_ENST00000542226.1_Missense_Mutation_p.P125L	NM_003842.4|NM_147187.2	NP_003833.4|NP_671716.2	O14763	TR10B_HUMAN	tumor necrosis factor receptor superfamily, member 10b	305					activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cell surface receptor linked signaling pathway|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|positive regulation of I-kappaB kinase/NF-kappaB cascade	plasma membrane	caspase activator activity|receptor activity|TRAIL binding			NS(1)|endometrium(2)|large_intestine(7)|liver(1)|lung(3)|skin(1)	15		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0179)|COAD - Colon adenocarcinoma(73;0.0703)		TGACTCCCCGGGGGACAACAT	0.562000													18	21					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179516831	179516831	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179516831G>A	ENST00000589042.1	-	204	39511	c.39287C>T	c.(39286-39288)cCc>cTc	p.P13096L	TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.P11589L|TTN_ENST00000342992.6_Missense_Mutation_p.P10662L|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11449			R -> L.				ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTTCAGGGGGAGGACTTTC	0.343000													16	55					0	0	1	0	0
TAS2R38	5726	broad.mit.edu	37	7	141672725	141672725	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:141672725G>A	ENST00000547270.1	-	1	848	c.765C>T	c.(763-765)ttC>ttT	p.F255F		NM_176817.4	NP_789787.4	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	255					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			NS(2)|breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)|stomach(1)	21	Melanoma(164;0.0171)					ATATCACAAAGAAGCAGAAAA	0.493000													27	22					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604077	179604077	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179604077G>A	ENST00000589042.1	-	48	14107	c.13883C>T	c.(13882-13884)tCc>tTc	p.S4628F	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S4265F|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S4390F|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S4457F|TTN_ENST00000591111.1_Missense_Mutation_p.S4311F|TTN_ENST00000342992.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4311	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTGTTATGGATGTTGTGAG	0.388000													20	20					0	0	1	0	0
ZPBP2	124626	broad.mit.edu	37	17	38031517	38031517	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:38031517G>A	ENST00000377940.3	+	6	792	c.653G>A	c.(652-654)cGa>cAa	p.R218Q	ZPBP2_ENST00000348931.4_Missense_Mutation_p.R240Q|ZPBP2_ENST00000584588.1_Missense_Mutation_p.R167Q	NM_198844.2	NP_942141.2	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2	240					binding of sperm to zona pellucida	extracellular region				kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			GCAAGAGATCGAATAGAAGAC	0.353000													8	33					0	0	1	0	0
ESRRG	2104	broad.mit.edu	37	1	216850658	216850658	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:216850658C>T	ENST00000391890.3	-	4	680	c.163G>A	c.(163-165)Gga>Aga	p.G55R	ESRRG_ENST00000360012.3_Missense_Mutation_p.G55R|ESRRG_ENST00000493603.1_Missense_Mutation_p.G55R|ESRRG_ENST00000493748.1_Missense_Mutation_p.G55R|ESRRG_ENST00000361395.2_Missense_Mutation_p.G55R|ESRRG_ENST00000487276.1_Missense_Mutation_p.G55R|ESRRG_ENST00000359162.2_Missense_Mutation_p.G55R|ESRRG_ENST00000366938.2_Missense_Mutation_p.G55R|ESRRG_ENST00000463665.1_Missense_Mutation_p.G55R|ESRRG_ENST00000366940.2_Missense_Mutation_p.G55R|ESRRG_ENST00000361525.3_Missense_Mutation_p.G55R|ESRRG_ENST00000366937.1_Missense_Mutation_p.G83R|ESRRG_ENST00000408911.3_Missense_Mutation_p.G78R	NM_001243515.1|NM_001243519.1	NP_001230444.1|NP_001230448.1	P62508	ERR3_HUMAN	estrogen-related receptor gamma	78					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(29)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	GAGTCAAGTCCGTTCTGATGG	0.567000													29	38					0	0	1	0	0
FAM57B	83723	broad.mit.edu	37	16	30036996	30036996	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:30036996C>T	ENST00000564806.1	-	3	486	c.441G>A	c.(439-441)agG>agA	p.R147R	FAM57B_ENST00000279389.4_Intron|FAM57B_ENST00000380495.4_Intron			Q71RH2	FA57B_HUMAN	family with sequence similarity 57, member B	0	TLC.					endoplasmic reticulum|integral to membrane				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(1)	14						AGGTCCCTCCCCTTCCTGTGA	0.607000													43	77					0	0	1	0	0
INSR	3643	broad.mit.edu	37	19	7122765	7122765	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:7122765G>A	ENST00000341500.5	-	18	3392	c.3353C>T	c.(3352-3354)cCc>cTc	p.P1118L	INSR_ENST00000302850.5_Missense_Mutation_p.P1130L	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	1130	Protein kinase.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAGGGTAGGGGGAGGGCGGCC	0.582000													19	30					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56344924	56344924	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:56344924C>T	ENST00000262290.4	+	12	2224	c.1908C>T	c.(1906-1908)ttC>ttT	p.F636F	LPO_ENST00000421678.2_Silent_p.F553F|LPO_ENST00000582328.1_Silent_p.F553F|LPO_ENST00000543544.1_Silent_p.F577F	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	636					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						GCAAGCAGTTCCAGCAGATCC	0.642000													7	23					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179440956	179440956	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179440956G>A	ENST00000589042.1	-	326	70127	c.69903C>T	c.(69901-69903)ttC>ttT	p.F23301F	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000460472.2_Silent_p.F14236F|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Silent_p.F14361F|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Silent_p.F14428F|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.F21660F|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Silent_p.F20733F|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586831.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21660	Fibronectin type-III 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGGAACAACGAACTGAGTGA	0.463000													15	20					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11676086	11676086	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:11676086G>A	ENST00000423059.3	-	2	944	c.693C>T	c.(691-693)ggC>ggT	p.G231G		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	231	TSP type-1 2.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GGTTTGGACAGCCAGAGCCTC	0.637000										HNSCC(18;0.044)			17	17					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42478219	42478219	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:42478219G>A	ENST00000434000.1	-	9	1274	c.992C>T	c.(991-993)cCc>cTc	p.P331L	GPATCH8_ENST00000591680.1_Missense_Mutation_p.P409L			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	409						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		AAGTAGAAAGGGAAAATTAGG	0.428000											OREG0024461	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	27					0	0	1	0	0
RHCE	6006	broad.mit.edu	37	1	25718510	25718510	+	Silent	SNP	C	C	T	rs143372707		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:25718510C>T	ENST00000349320.3	-	6	949	c.561G>A	c.(559-561)acG>acA	p.T187T	RHCE_ENST00000294413.7_Silent_p.T203T|RHCE_ENST00000243186.6_Silent_p.T203T|RHCE_ENST00000346452.4_Intron|RHCE_ENST00000455194.1_Intron|RHCE_ENST00000340849.4_Intron|RHCE_ENST00000425135.1_Silent_p.T203T|RHCE_ENST00000374352.2_Silent_p.T187T|RHCE_ENST00000413854.1_Silent_p.T203T|RHCE_ENST00000349438.4_Silent_p.T203T			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	203						integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		AACTGGGTATCGTTGCTCTCT	0.532000													73	24					0	0	1	0	0
C16orf89	146556	broad.mit.edu	37	16	5115824	5115824	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:5115824G>A	ENST00000315997.5	-	1	287	c.86C>T	c.(85-87)gCt>gTt	p.A29V	C16orf89_ENST00000350219.4_Missense_Mutation_p.A67V|C16orf89_ENST00000422873.1_Missense_Mutation_p.A67V|C16orf89_ENST00000472572.3_Missense_Mutation_p.A29V|ALG1_ENST00000588623.1_Intron|C16orf89_ENST00000474471.3_Missense_Mutation_p.A29V	NM_152459.4	NP_689672.4	Q6UX73	CP089_HUMAN	chromosome 16 open reading frame 89	29						extracellular region				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	12						TTTACTTTCAGCAGTGTCCAG	0.602000													15	24					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41069821	41069821	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:41069821C>T	ENST00000324545.7	+	33	5708	c.5075C>T	c.(5074-5076)tCa>tTa	p.S1692L	USP9X_ENST00000378308.2_Missense_Mutation_p.S1692L	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1692					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						TTTTTTAATTCATTGGTGGAT	0.363000													23	39					0	0	1	0	0
GEMIN4	50628	broad.mit.edu	37	17	649279	649279	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:649279G>A	ENST00000576778.1	-	1	3312	c.1971C>T	c.(1969-1971)gaC>gaT	p.D657D	GEMIN4_ENST00000319004.5_Silent_p.D668D			P57678	GEMI4_HUMAN	gem (nuclear organelle) associated protein 4	668					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		TCAGACTGAGGTCTACCTCTT	0.522000													7	17					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129774250	129774250	+	Missense_Mutation	SNP	C	C	T	rs140574226		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:129774250C>T	ENST00000421865.2	+	46	6596	c.6547C>T	c.(6547-6549)Ctc>Ttc	p.L2183F		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2183	Laminin G-like 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGATAACCTCCTCTTTTATCT	0.348000													12	18					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18828730	18828730	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:18828730G>A	ENST00000446231.2	-	57	10369	c.9957C>T	c.(9955-9957)gcC>gcT	p.A3319A	SMG1_ENST00000389467.3_Silent_p.A3320A			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	3319					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						CCAGGTTTAAGGCTTCTGCAG	0.413000													4	5					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40342430	40342430	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:40342430G>A	ENST00000406785.1	-	8	2966	c.2777C>T	c.(2776-2778)tCc>tTc	p.S926F	SLC8A1_ENST00000406391.2_Missense_Mutation_p.S926F|SLC8A1_ENST00000405901.3_Missense_Mutation_p.S957F|SLC8A1_ENST00000403092.1_Missense_Mutation_p.S962F|SLC8A1_ENST00000408028.2_Missense_Mutation_p.S954F|SLC8A1-AS1_ENST00000444629.1_RNA|SLC8A1-AS1_ENST00000435515.1_RNA|SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1-AS1_ENST00000597170.1_RNA|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1_ENST00000542756.1_Missense_Mutation_p.S957F|SLC8A1_ENST00000542024.1_Missense_Mutation_p.S926F|SLC8A1_ENST00000405269.1_Missense_Mutation_p.S926F|SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1-AS1_ENST00000599956.1_RNA|SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1-AS1_ENST00000597385.1_RNA|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1_ENST00000402441.1_Missense_Mutation_p.S926F|SLC8A1_ENST00000332839.4_Missense_Mutation_p.S962F|SLC8A1-AS1_ENST00000593848.1_RNA			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	962					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CTCCAGGGAGGAGAAGAAAAT	0.428000													30	19					0	0	1	0	0
SLC30A8	169026	broad.mit.edu	37	8	118184839	118184839	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:118184839G>A	ENST00000427715.2	+	11	1316	c.882G>A	c.(880-882)acG>acA	p.T294T	SLC30A8_ENST00000456015.2_Silent_p.T343T|SLC30A8_ENST00000521243.1_Silent_p.T294T|SLC30A8_ENST00000519688.1_Silent_p.T294T	NM_001172813.1|NM_001172815.1	NP_001166284.1|NP_001166286.1	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	343					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			AAAGCTTTACGATGCACTCAC	0.502000													48	84					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9984935	9984935	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:9984935C>T	ENST00000396573.2	-	5	1339	c.1030G>A	c.(1030-1032)Gat>Aat	p.D344N	GRIN2A_ENST00000404927.2_Missense_Mutation_p.D344N|GRIN2A_ENST00000562109.1_Missense_Mutation_p.D344N|GRIN2A_ENST00000535259.1_Missense_Mutation_p.D187N|GRIN2A_ENST00000396575.2_Missense_Mutation_p.D344N|GRIN2A_ENST00000330684.3_Missense_Mutation_p.D344N	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	344					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCTTTGCCATCCCATGTAACA	0.438000													28	29					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38950723	38950723	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:38950723G>A	ENST00000357387.3	-	31	3257	c.3227C>T	c.(3226-3228)tCt>tTt	p.S1076F	RICTOR_ENST00000296782.5_Missense_Mutation_p.S1076F	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	1076					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					TATGGGTCCAGATCGGTCATA	0.368000													27	48					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101797334	101797334	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr9:101797334G>A	ENST00000375001.3	+	18	2541	c.2118G>A	c.(2116-2118)ggG>ggA	p.G706G		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	706	Triple-helical region 2 (COL2).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding	p.G706G(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				GACCCCCGGGGAAAAAGGGAC	0.617000													29	6					0	0	1	0	0
KRT6B	3854	broad.mit.edu	37	12	52841668	52841668	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:52841668C>T	ENST00000252252.3	-	7	1365	c.1318G>A	c.(1318-1320)Gac>Aac	p.D440N		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	440	Coil 2.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		CGGGCCAGGTCCTGCTTGGCC	0.622000													54	58					0	0	1	0	0
FOXK2	3607	broad.mit.edu	37	17	80521331	80521331	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:80521331C>T	ENST00000335255.5	+	2	695	c.521C>T	c.(520-522)gCc>gTc	p.A174V		NM_004514.3	NP_004505.2	Q01167	FOXK2_HUMAN	forkhead box K2	174					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	17	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			CCAGTGAAGGCCGTACAGCCA	0.582000													12	27					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7723467	7723467	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:7723467C>T	ENST00000303635.7	+	9	1067	c.860C>T	c.(859-861)tCg>tTg	p.S287L	CAMTA1_ENST00000439411.2_Missense_Mutation_p.S287L	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	287					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding	p.S287L(1)		breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CGCATCATCTCGCCCAAGGTG	0.637000			T	WWTR1	epitheliod hemangioendothelioma								51	160					0	0	1	0	0
PLD2	5338	broad.mit.edu	37	17	4721600	4721600	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:4721600C>T	ENST00000263088.6	+	19	2060	c.1929C>T	c.(1927-1929)ttC>ttT	p.F643F	PLD2_ENST00000572940.1_Silent_p.F643F	NM_001243108.1|NM_002663.4	NP_001230037.1|NP_002654.3	O14939	PLD2_HUMAN	phospholipase D2	643	Catalytic.				cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)	31					Choline(DB00122)	AGAATCAGTTCTTCATTAGCT	0.572000													16	30					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189873782	189873782	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:189873782T>A	ENST00000304636.3	+	48	3828	c.3658T>A	c.(3658-3660)Tat>Aat	p.Y1220N	COL3A1_ENST00000317840.5_Missense_Mutation_p.Y917N	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1220					axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TGCCCCGTATTATGGAGATGA	0.488000													37	57					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	16					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32836601	32836601	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:32836601G>T	ENST00000380250.3	+	53	8264	c.7768G>T	c.(7768-7770)Gag>Tag	p.E2590*		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2590					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GCAGATTTCTGAGGGTTCAAA	0.398000													26	18					1.12875e-08	1.13926e-08	1	1	0
PTCHD4	442213	broad.mit.edu	37	6	48036238	48036238	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:48036238G>A	ENST00000543600.1	-	1	142	c.103C>T	c.(103-105)Ctg>Ttg	p.L35L	PTCHD4_ENST00000339488.4_Silent_p.L52L			Q6ZW05	CF138_HUMAN	patched domain containing 4	52						integral to membrane	hedgehog receptor activity										GTGATTGTCAGGACTGCGGGC	0.672000													4	13					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	94993272	94993272	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:94993272G>A	ENST00000265627.5	-	6	608	c.598C>T	c.(598-600)Cgc>Tgc	p.R200C	PON3_ENST00000427422.1_Missense_Mutation_p.R200C|PON1_ENST00000542556.1_Intron	NM_000940.2	NP_000931.1			paraoxonase 3											breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			TAAGTCCAGCGAAGATCCAAG	0.448000													58	102					0	0	1	0	0
ZDHHC13	54503	broad.mit.edu	37	11	19172302	19172302	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:19172302A>T	ENST00000446113.2	+	6	669	c.548A>T	c.(547-549)cAg>cTg	p.Q183L	ZDHHC13_ENST00000399351.3_Missense_Mutation_p.Q53L|ZDHHC13_ENST00000532812.1_3'UTR	NM_019028.2	NP_061901.2	Q8IUH4	ZDH13_HUMAN	zinc finger, DHHC-type containing 13	183					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|palmitoyltransferase activity|signal transducer activity|zinc ion binding			NS(1)|kidney(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6						GTAAATGGGCAGACACCTCTC	0.323000													14	23					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220500082	220500082	+	Silent	SNP	C	C	T	rs140366514		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:220500082C>T	ENST00000358055.3	+	13	2348	c.1836C>T	c.(1834-1836)ccC>ccT	p.P612P	SLC4A3_ENST00000373760.2_Silent_p.P612P|SLC4A3_ENST00000317151.3_Silent_p.P612P|SLC4A3_ENST00000273063.6_Silent_p.P639P|SLC4A3_ENST00000373762.3_Silent_p.P639P			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	612					bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTGTGATCCCCCCGTCCGAGG	0.607000													12	39					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82763687	82763687	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:82763687G>A	ENST00000423517.2	-	3	3516	c.3179C>T	c.(3178-3180)cCt>cTt	p.P1060L	PCLO_ENST00000333891.8_Missense_Mutation_p.P1060L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1006					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTTGCAGAGAGGACAGGTTGA	0.423000													9	9					0	0	1	0	0
OR52B6	340980	broad.mit.edu	37	11	5602845	5602845	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:5602845C>T	ENST00000345043.2	+	1	739	c.739C>T	c.(739-741)Ctc>Ttc	p.L247F	AC015691.13_ENST00000394793.2_RNA|HBG2_ENST00000380259.2_Intron	NM_001005162.2	NP_001005162.2	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B, member 6	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)	12		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGTCTTCCGCCTCCTTTCTCA	0.502000													25	42					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76657031	76657031	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:76657031C>T	ENST00000369950.3	-	14	2233	c.2044_splice	c.e14+1	p.A682_splice	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	682	SEA 2.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				ATTCTTTTACCTGGTTCAATG	0.418000													6	10					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453886	84453886	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:84453886G>A	ENST00000377084.2	-	1	2642	c.1757C>T	c.(1756-1758)tCg>tTg	p.S586L		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	586						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TAACGTGGGCGAGATCCTAGC	0.542000													8	9					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76024295	76024295	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:76024295C>T	ENST00000393004.2	-	5	1474	c.1253G>A	c.(1252-1254)aGt>aAt	p.S418N	FILIP1_ENST00000370020.1_Missense_Mutation_p.S319N|FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Missense_Mutation_p.S418N			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	418										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						GAGCTCCTTACTATGGTGTTC	0.423000													33	53					0	0	1	0	0
OR5L1	219437	broad.mit.edu	37	11	55579708	55579708	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:55579708C>T	ENST00000333973.2	+	1	855	c.766C>T	c.(766-768)Ctt>Ttt	p.L256F		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				TGGAACAGTCCTTTCCATTTA	0.517000													10	19					0	0	1	0	0
ANGPT1	284	broad.mit.edu	37	8	108297037	108297037	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:108297037C>T	ENST00000520734.1	-	6	763	c.478G>A	c.(478-480)Gag>Aag	p.E160K	ANGPT1_ENST00000520052.1_Missense_Mutation_p.E159K|ANGPT1_ENST00000518386.1_Intron			Q15389	ANGP1_HUMAN	angiopoietin 1	360					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			NS(1)|breast(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(13)|ovary(4)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	43	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			AAAATAAACTCATTCCCCAGC	0.418000													6	35					0	0	1	0	0
SLC28A2	9153	broad.mit.edu	37	15	45545629	45545629	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:45545629G>A	ENST00000347644.3	+	3	146		c.e3-1		CTD-2651B20.3_ENST00000559003.1_RNA	NM_004212.3	NP_004203.2	O43868	S28A2_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 2						nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(4)|skin(1)	26		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		TGTGCTTGTAGGAAAAAGAAG	0.557000													12	9					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69653823	69653823	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:69653823G>A	ENST00000370598.1	+	6	1953	c.1132G>A	c.(1132-1134)Gga>Aga	p.G378R		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	378	TSP type-1 2.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.G378*(1)		NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				TCCTCAGTATGGAGGAAGGCC	0.453000													11	16					0	0	1	0	0
MRPS22	56945	broad.mit.edu	37	3	139069088	139069088	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:139069088G>A	ENST00000495075.1	+	6	1004	c.572G>A	c.(571-573)cGa>cAa	p.R191Q	MRPS22_ENST00000310776.4_Missense_Mutation_p.R191Q|MRPS22_ENST00000465056.1_Missense_Mutation_p.R190Q|MRPS22_ENST00000478464.1_Missense_Mutation_p.R150Q			P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	191						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	12						GAACGGGACCGAATGATACAA	0.373000													6	18					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	49710963	49710963	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:49710963G>A	ENST00000451037.2	-	8	1778	c.838C>T	c.(838-840)Ctg>Ttg	p.L280L	CA10_ENST00000285273.4_Silent_p.L280L|CA10_ENST00000340813.6_Silent_p.L286L|CA10_ENST00000442502.2_Silent_p.L280L|CA10_ENST00000570565.1_Silent_p.L205L	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	280					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			CTCATGCTCAGAAAGATCTGA	0.507000													22	12					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70472696	70472696	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:70472696G>A	ENST00000373998.1	-	2	1107	c.410C>T	c.(409-411)cCt>cTt	p.P137L	ZMYM3_ENST00000373984.3_Missense_Mutation_p.P137L|ZMYM3_ENST00000373981.1_Missense_Mutation_p.P137L|ZMYM3_ENST00000353904.2_Missense_Mutation_p.P137L|ZMYM3_ENST00000373988.1_Missense_Mutation_p.P137L|ZMYM3_ENST00000373978.1_Missense_Mutation_p.P137L|ZMYM3_ENST00000373982.1_Missense_Mutation_p.P137L|ZMYM3_ENST00000314425.5_Missense_Mutation_p.P137L|ZMYM3_ENST00000489332.1_5'UTR	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	137					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					TAGCCCCTCAGGTGAACAGGA	0.567000													11	8					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69693184	69693184	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:69693184G>A	ENST00000265403.7	+	5	1252	c.1225G>A	c.(1225-1227)Gga>Aga	p.G409R	UGT2B10_ENST00000458688.2_Missense_Mutation_p.G325R	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	409					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						GAAGGCCAAGGGAGCAGCTGT	0.428000													59	60					0	0	1	0	0
MUC21	394263	broad.mit.edu	37	6	30954281	30954281	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:30954281C>T	ENST00000376296.3	+	2	570	c.329C>T	c.(328-330)tCc>tTc	p.S110F	MUC21_ENST00000486149.2_5'UTR	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	110	28 X 15 AA approximate tandem repeats.|Ser-rich.					integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						AACTCTGAGTCCAGCACAACC	0.577000													63	209					0	0	1	0	0
ASB4	51666	broad.mit.edu	37	7	95115410	95115410	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:95115410G>A	ENST00000325885.5	+	1	198	c.127G>A	c.(127-129)Gat>Aat	p.D43N	ASB4_ENST00000257621.4_Intron|ASB4_ENST00000428113.1_Missense_Mutation_p.D43N	NM_016116.2	NP_057200.1	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box containing 4	43					intracellular signal transduction					central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|pancreas(1)|prostate(1)|skin(2)	20	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			AAGGCAAATAGATGTGGACAC	0.348000													35	43					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564298	176564298	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:176564298C>T	ENST00000367662.3	+	3	2722	c.1558C>T	c.(1558-1560)Cgg>Tgg	p.R520W	PAPPA2_ENST00000367661.3_Missense_Mutation_p.R520W	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	520	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.R520G(2)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CTGGCCCCTTCGGGGAGAGAA	0.537000													16	18					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138330043	138330043	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:138330043C>T	ENST00000409968.1	+	17	3518	c.3340C>T	c.(3340-3342)Ccc>Tcc	p.P1114S	THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Missense_Mutation_p.P1086S|THSD7B_ENST00000272643.3_Missense_Mutation_p.P1117S					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GGATGAAATTCCCCCAGAAAC	0.453000													12	13					0	0	1	0	0
CD86	942	broad.mit.edu	37	3	121822572	121822572	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:121822572G>A	ENST00000330540.2	+	3	394	c.278G>A	c.(277-279)tGg>tAg	p.W93*	CD86_ENST00000493101.1_Intron|CD86_ENST00000469710.1_Nonsense_Mutation_p.W11*|CD86_ENST00000264468.5_Intron|CD86_ENST00000393627.2_Nonsense_Mutation_p.W87*	NM_175862.4	NP_787058.4	P42081	CD86_HUMAN	CD86 molecule	93	Ig-like V-type.				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	23				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	TCGGACAGTTGGACCCTGAGA	0.428000													25	46					0	0	1	0	0
UBQLN3	50613	broad.mit.edu	37	11	5530463	5530463	+	Missense_Mutation	SNP	G	G	A	rs146563055		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:5530463G>A	ENST00000311659.4	-	2	473	c.326C>T	c.(325-327)aCc>aTc	p.T109I	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	109										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGGCCCTGGGTAGGGACAGA	0.607000													13	11					0	0	1	0	0
EPS15L1	58513	broad.mit.edu	37	19	16535920	16535920	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:16535920G>A	ENST00000602009.1	-	3	1199	c.304C>T	c.(304-306)Ccc>Tcc	p.P102S	EPS15L1_ENST00000455140.2_Missense_Mutation_p.P256S|EPS15L1_ENST00000594975.1_Missense_Mutation_p.P256S|EPS15L1_ENST00000535753.2_Missense_Mutation_p.P256S|EPS15L1_ENST00000597937.1_Missense_Mutation_p.P256S|EPS15L1_ENST00000248070.6_Missense_Mutation_p.P256S			Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	256	EH 1.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						CTGTGCTTGGGGGACAGGCTC	0.632000													22	37					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20496630	20496630	+	RNA	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:20496630G>A	ENST00000555186.1	+	0	683					NR_038836.1																						TCATGAAGGGGAAGCCGAGGG	0.438000													8	26					0	0	1	0	0
TAAR5	9038	broad.mit.edu	37	6	132910384	132910384	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:132910384C>T	ENST00000258034.2	-	1	493	c.442G>A	c.(442-444)Gtg>Atg	p.V148M		NM_003967.2	NP_003958.2	O14804	TAAR5_HUMAN	trace amine associated receptor 5	148					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	32	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		GCCACCCTCACTGTGAACTTG	0.547000													16	15					0	0	1	0	0
OR56B4	196335	broad.mit.edu	37	11	6129275	6129275	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:6129275C>T	ENST00000316529.3	+	1	362	c.267C>T	c.(265-267)gcC>gcT	p.A89A		NM_001005181.1	NP_001005181.1	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B, member 4	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|lung(10)|skin(6)|urinary_tract(2)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGATCCTGGCCATCTTCTGGT	0.502000													16	15					0	0	1	0	0
SLC2A9	56606	broad.mit.edu	37	4	9892241	9892241	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:9892241G>A	ENST00000506583.1	-	11	1338	c.1121C>T	c.(1120-1122)aCc>aTc	p.T374I	SLC2A9_ENST00000264784.3_Missense_Mutation_p.T403I|SLC2A9_ENST00000309065.3_Missense_Mutation_p.T374I			Q9NRM0	GTR9_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 9	403					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(1)	35						CACCTGCAGGGTCAGCGTGAT	0.532000													10	20					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50745703	50745703	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:50745703A>T	ENST00000300589.2	+	4	1986	c.1881A>T	c.(1879-1881)agA>agT	p.R627S		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	627					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				CTTTGCTCAGACACCTCTTCA	0.587000													18	32					0	0	1	0	0
SMTN	6525	broad.mit.edu	37	22	31487802	31487802	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:31487802C>T	ENST00000333137.7	+	11	1819	c.1601C>T	c.(1600-1602)cCc>cTc	p.P534L	SMTN_ENST00000358743.1_Missense_Mutation_p.P534L|SMTN_ENST00000347557.2_Missense_Mutation_p.P534L	NM_001207018.1|NM_134269.2	NP_001193947.1|NP_599031.1	P53814	SMTN_HUMAN	smoothelin	534					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			breast(2)|endometrium(2)|large_intestine(5)|lung(9)|ovary(3)|pancreas(1)|prostate(3)	25						AGCCATGCCCCCCCCAGTAGC	0.632000													6	13					0	0	1	0	0
CRHR2	1395	broad.mit.edu	37	7	30693177	30693177	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:30693177C>T	ENST00000471646.1	-	12	1552	c.1135G>A	c.(1135-1137)Gac>Aac	p.D379N	CRHR2_ENST00000348438.4_Missense_Mutation_p.D406N|CRHR2_ENST00000341843.4_Missense_Mutation_p.D365N|CRHR2_ENST00000506074.2_3'UTR	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	379					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GAGTGATGGTCCTGCCAGCGG	0.642000													51	54					0	0	1	0	0
ZNF645	158506	broad.mit.edu	37	X	22292036	22292036	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:22292036C>T	ENST00000323684.1	+	1	972	c.928C>T	c.(928-930)Cgt>Tgt	p.R310C		NM_152577.3	NP_689790.1	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	310	Pro-rich.					intracellular	zinc ion binding			cervix(1)|endometrium(4)|large_intestine(8)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	27						TAACTCGGTTCGTAGCCAAGT	0.468000													27	52					0	0	1	0	0
POPDC3	64208	broad.mit.edu	37	6	105607652	105607652	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:105607652G>A	ENST00000254765.3	-	3	806	c.528C>T	c.(526-528)ttC>ttT	p.F176F	BVES-AS1_ENST00000580511.1_RNA|BVES-AS1_ENST00000580854.1_RNA|POPDC3_ENST00000474760.1_5'UTR|BVES-AS1_ENST00000369122.3_RNA	NM_022361.4	NP_071756.2	Q9HBV1	POPD3_HUMAN	popeye domain containing 3	176				F -> S (in Ref. 1; AAG23404).		integral to membrane				NS(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(3)|urinary_tract(1)	26		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				ACTGAAGGGGGAAAATGTAAT	0.443000													6	11					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171080110	171080110	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:171080110G>A	ENST00000367755.4	+	6	910	c.799G>A	c.(799-801)Gaa>Aaa	p.E267K	FMO3_ENST00000542847.1_Missense_Mutation_p.E247K|FMO3_ENST00000392085.2_Missense_Mutation_p.E267K|FMO3_ENST00000538429.1_Missense_Mutation_p.E204K	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	267					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATTCAAGCATGAAAACTATGG	0.438000													32	38					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56355504	56355504	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:56355504G>A	ENST00000340482.3	-	6	1160	c.984C>T	c.(982-984)atC>atT	p.I328I	MPO_ENST00000225275.3_Silent_p.I296I			P05164	PERM_HUMAN	myeloperoxidase	296					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	CATTGGGCGGGATCTGAGGCA	0.632000													20	42					0	0	1	0	0
MDFIC	29969	broad.mit.edu	37	7	114619812	114619812	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:114619812C>T	ENST00000257724.3	+	4	1059	c.796C>T	c.(796-798)Caa>Taa	p.Q266*	MDFIC_ENST00000393486.1_Nonsense_Mutation_p.Q157*			Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing	157					activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleolus|nucleus	cyclin binding|Tat protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	8						TGTCTTTTCCCAAAAGACAGG	0.338000													20	20					0	0	1	0	0
SCML4	256380	broad.mit.edu	37	6	108067960	108067960	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:108067960G>A	ENST00000369022.2	-	3	455	c.246C>T	c.(244-246)gaC>gaT	p.D82D	SCML4_ENST00000369020.3_Silent_p.D140D|SCML4_ENST00000369021.3_Silent_p.D111D			Q8N228	SCML4_HUMAN	sex comb on midleg-like 4 (Drosophila)	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(1)	25		all_cancers(87;3.26e-06)|Acute lymphoblastic leukemia(125;3.08e-08)|all_hematologic(75;1.15e-06)|all_epithelial(87;0.00142)|Colorectal(196;0.0316)		BRCA - Breast invasive adenocarcinoma(108;0.01)|Epithelial(106;0.0509)|all cancers(137;0.0586)|OV - Ovarian serous cystadenocarcinoma(136;0.0758)		GGTGGGCGCAGTCGATGCAGG	0.637000													22	33					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124436232	124436232	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:124436232G>A	ENST00000360013.3	+	59	8542	c.8415_splice	c.e59+1	p.K2805_splice	KALRN_ENST00000428018.2_Splice_Site_p.K1076_splice|KALRN_ENST00000291478.4_Splice_Site_p.K1108_splice	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2804	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TGGACATAAAGGTAATAAGAA	0.507000													4	27					0	0	1	0	0
ZNF77	58492	broad.mit.edu	37	19	2934719	2934719	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:2934719G>A	ENST00000314531.4	-	4	498	c.406C>T	c.(406-408)Cct>Tct	p.P136S		NM_021217.2	NP_067040.1	Q15935	ZNF77_HUMAN	zinc finger protein 77	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTTCGGTAGGGTAACTCTTG	0.507000													19	76					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71354291	71354291	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:71354291G>A	ENST00000392650.3	-	40	5520	c.5520C>T	c.(5518-5520)atC>atT	p.I1840I	SDK2_ENST00000388726.3_Silent_p.I1821I|SDK2_ENST00000410094.1_5'UTR	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1840	Fibronectin type-III 13.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						AGTGAATGGCGATGGCAGAGC	0.657000													48	87					0	0	1	0	0
IGHV3-38	28429	broad.mit.edu	37	14	106866548	106866548	+	RNA	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:106866548G>A	ENST00000390618.2	-	0	283																											ACCACTAATGGATGAGACCCA	0.527000													65	99					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43519324	43519324	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:43519324G>A	ENST00000395891.1	+	17	3820	c.3215G>A	c.(3214-3216)cGa>cAa	p.R1072Q	HECW1_ENST00000453890.1_Missense_Mutation_p.R1038Q	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1072					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity	p.R1051Q(2)		NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CAGAGGCTCCGAAGTTACAGC	0.552000													45	63					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15769135	15769135	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:15769135C>T	ENST00000221307.7	+	10	1225	c.1177C>T	c.(1177-1179)Ccc>Tcc	p.P393S	CYP4F3_ENST00000585846.1_Missense_Mutation_p.P393S|CYP4F3_ENST00000591058.1_Missense_Mutation_p.P393S|CYP4F3_ENST00000586182.1_Missense_Mutation_p.P393S	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	393					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding	p.P393S(1)		endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						GAGGCTGCATCCCCCAGTCCC	0.627000													40	46					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35823827	35823827	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:35823827G>A	ENST00000085219.5	+	3	478	c.412_splice	c.e3+1	p.E138_splice	CD22_ENST00000536635.2_Splice_Site_p.E138_splice|CD22_ENST00000341773.6_Splice_Site_p.E138_splice|CD22_ENST00000544992.2_Splice_Site_p.E138_splice|CD22_ENST00000270311.6_Splice_Site_p.E18_splice|CD22_ENST00000419549.2_Splice_Site_p.L3_splice|CD22_ENST00000595419.1_3'UTR|CD22_ENST00000594250.1_Splice_Site_p.E138_splice	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	138	Ig-like V-type.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CAATGTCTCTGGTAAGGCCTT	0.572000													8	19					0	0	1	0	0
IGKV1D-13	28902	broad.mit.edu	37	2	90192975	90192975	+	RNA	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:90192975C>T	ENST00000390275.2	+	0	208																											CGCTCAGCTCCTGGGGCTTCT	0.552000													37	122					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123909411	123909411	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:123909411G>A	ENST00000330487.5	-	1	306	c.298C>T	c.(298-300)Ctc>Ttc	p.L100F		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	100					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AAAAAATAGAGCTGAGCCACG	0.532000													32	60					0	0	1	0	0
RPS26	6231	broad.mit.edu	37	12	56437912	56437912	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:56437912C>T	ENST00000356464.5	+	4	636	c.322C>T	c.(322-324)Cca>Tca	p.P108S	RPS26_ENST00000552361.1_Missense_Mutation_p.P108S			P62854	RS26_HUMAN	ribosomal protein S26	108					endocrine pancreas development|negative regulation of RNA splicing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	mRNA binding|protein binding|structural constituent of ribosome			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)	7			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGGTGCTGCCCCACGTCCCCC	0.428000													17	64					0	0	1	0	0
MIP	4284	broad.mit.edu	37	12	56848375	56848375	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:56848375G>A	ENST00000257979.4	-	1	51	c.23C>T	c.(22-24)tCc>tTc	p.S8F	MIP_ENST00000555551.1_Intron	NM_012064.3	NP_036196.1	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	8					response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	16						CCTCCAAAAGGAGGCTGATCG	0.587000													31	40					0	0	1	0	0
CPN2	1370	broad.mit.edu	37	3	194062807	194062807	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:194062807G>A	ENST00000323830.3	-	2	714	c.625C>T	c.(625-627)Ccc>Tcc	p.P209S	CPN2_ENST00000429275.1_Missense_Mutation_p.P209S	NM_001080513.2	NP_001073982.2	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	209					protein stabilization	extracellular region	enzyme regulator activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(5)|prostate(1)	27	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		ACACCCTGGGGGAGACCAGAG	0.627000													7	21					0	0	1	0	0
MROH8	140699	broad.mit.edu	37	20	35766335	35766335	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr20:35766335G>A	ENST00000400441.3	-	13	1526	c.1527C>T	c.(1525-1527)tcC>tcT	p.S509S	MROH8_ENST00000217333.8_Silent_p.S338S|MROH8_ENST00000441008.2_Silent_p.S495S					maestro heat-like repeat family member 8																		GGCTGATTATGGATAACTGGG	0.408000													4	11					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634224	70634224	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:70634224C>T	ENST00000381269.2	-	2	1669	c.916G>A	c.(916-918)Ggg>Agg	p.G306R	SLC8A3_ENST00000356921.2_Missense_Mutation_p.G306R|SLC8A3_ENST00000534137.1_Missense_Mutation_p.G306R|SLC8A3_ENST00000357887.3_Missense_Mutation_p.G306R|SLC8A3_ENST00000528359.1_Missense_Mutation_p.G306R	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	306					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		ACTTCCTTCCCTTCCAGGGGC	0.488000													32	0					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76471196	76471196	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:76471196G>A	ENST00000396423.2	+	8	1141	c.1017G>A	c.(1015-1017)atG>atA	p.M339I	HNF4G_ENST00000354370.1_Missense_Mutation_p.M302I	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	302					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			CGTGGCAAATGATTGAGCAAA	0.428000													42	51					0	0	1	0	0
NOP14	8602	broad.mit.edu	37	4	2943383	2943383	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:2943383G>A	ENST00000416614.2	-	15	2190	c.2125C>T	c.(2125-2127)Cac>Tac	p.H709Y	NOP14-AS1_ENST00000503709.1_RNA|NOP14-AS1_ENST00000515194.1_RNA|NOP14-AS1_ENST00000507702.1_RNA|NOP14_ENST00000507120.1_5'UTR|NOP14-AS1_ENST00000512712.2_RNA|NOP14-AS1_ENST00000505731.1_RNA|NOP14_ENST00000314262.6_Missense_Mutation_p.H709Y|NOP14_ENST00000502735.1_Missense_Mutation_p.H709Y|NOP14_ENST00000398071.4_Missense_Mutation_p.H709Y			P78316	NOP14_HUMAN	NOP14 nucleolar protein	709					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	30						ATGATGGCGTGGAAGGATGGC	0.667000													7	22					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615812	179615812	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179615812T>A	ENST00000360870.5	-	46	11537	c.11315A>T	c.(11314-11316)aAt>aTt	p.N3772I	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000589042.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9609							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCATGTGGATTTTGCACAAT	0.348000													39	28					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187524477	187524477	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:187524477G>A	ENST00000441802.2	-	19	11412	c.11203C>T	c.(11203-11205)Cag>Tag	p.Q3735*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3735					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CAGAGTTTCTGGAATACATTC	0.463000										HNSCC(5;0.00058)			10	13					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35242162	35242162	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:35242162C>T	ENST00000408931.3	-	8	1750	c.1224G>A	c.(1222-1224)ggG>ggA	p.G408G		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	408						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						TGGGGCCACTCCCTTGCATGG	0.557000													5	24					0	0	1	0	0
UPB1	51733	broad.mit.edu	37	22	24911227	24911227	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:24911227G>A	ENST00000413389.2	+	6	2069	c.476G>A	c.(475-477)aGg>aAg	p.R159K	UPB1_ENST00000326010.5_Missense_Mutation_p.R227K			Q9UBR1	BUP1_HUMAN	ureidopropionase, beta	227	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	22	Colorectal(2;0.0339)					CAGTTCGGAAGGATCGCGGTG	0.542000													40	42					0	0	1	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115612744	115612744	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:115612744G>A	ENST00000361384.2	-	1	1115	c.198C>T	c.(196-198)ccC>ccT	p.P66P	DCLRE1A_ENST00000369305.1_Silent_p.P66P	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	66	Nuclear localization region.				cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		CATTTCCAAGGGGCACTTCAT	0.433000								Other identified genes with known or suspected DNA repair function					76	8					0	0	1	0	0
CD1C	911	broad.mit.edu	37	1	158261127	158261127	+	Missense_Mutation	SNP	C	C	T	rs145638725		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:158261127C>T	ENST00000368170.3	+	2	544	c.265C>T	c.(265-267)Cgt>Tgt	p.R89C		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	89					antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding	p.R89C(1)		NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					GTTGTTATTTCGTTTCTACCT	0.398000													19	28					0	0	1	0	0
RIPK4	54101	broad.mit.edu	37	21	43161378	43161378	+	Missense_Mutation	SNP	G	G	A	rs147500393		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr21:43161378G>A	ENST00000352483.2	-	9	2183	c.2119C>T	c.(2119-2121)Cgg>Tgg	p.R707W	RIPK4_ENST00000544709.1_Missense_Mutation_p.R596W|AP001615.9_ENST00000423276.1_RNA|RIPK4_ENST00000542057.1_Missense_Mutation_p.R596W|RIPK4_ENST00000332512.3_Missense_Mutation_p.R659W			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	659						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						CCAGCGCCCCGATGCAGGAGC	0.672000													51	25					0	0	1	0	0
IGFL1	374918	broad.mit.edu	37	19	46733364	46733364	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:46733364G>A	ENST00000437936.1	+	2	48		c.e2-1		AC006262.10_ENST00000597337.1_RNA	NM_198541.1	NP_940943.1	Q6UW32	IGFL1_HUMAN	IGF-like family member 1							extracellular space	protein binding			lung(5)	5		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.00242)|all cancers(93;0.0132)|GBM - Glioblastoma multiforme(486;0.0294)|Epithelial(262;0.201)		CTTTCCCACAGCTGTCTTTGC	0.562000													15	37					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237994814	237994814	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:237994814G>A	ENST00000366574.2	+	104	15074	c.14756_splice	c.e104-1	p.L4919_splice	RYR2_ENST00000360064.6_Splice_Site_p.L4925_splice|RYR2_ENST00000462585.1_3'UTR|RYR2_ENST00000542537.1_Splice_Site_p.L4903_splice	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4919					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTATCTGTAGGTTTTTTCTGA	0.328000													7	18					0	0	1	0	0
ROR1	4919	broad.mit.edu	37	1	64603126	64603126	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:64603126C>T	ENST00000371079.1	+	5	932	c.557C>T	c.(556-558)aCc>aTc	p.T186I	RP11-24J23.2_ENST00000424995.1_RNA|ROR1_ENST00000545203.1_5'UTR|ROR1_ENST00000482426.1_3'UTR|ROR1_ENST00000371080.1_Missense_Mutation_p.T186I	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	186	FZ.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						GGCAACCGCACCGTCTATATG	0.388000													19	57					0	0	1	0	0
OR2D3	120775	broad.mit.edu	37	11	6943201	6943201	+	Silent	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:6943201A>G	ENST00000317834.3	+	1	997	c.969A>G	c.(967-969)agA>agG	p.R323R		NM_001004684.1	NP_001004684.1	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D, member 3	323					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|large_intestine(7)|lung(12)|prostate(3)|skin(1)|stomach(1)	27		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TAGTTGGGAGAAAGTGCTTCT	0.398000													10	12					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175898903	175898903	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:175898903C>T	ENST00000359240.3	+	5	2897	c.2227C>T	c.(2227-2229)Cct>Tct	p.P743S	ADAM29_ENST00000514159.1_Missense_Mutation_p.P743S|RP13-577H12.2_ENST00000507525.1_RNA|ADAM29_ENST00000404450.4_Missense_Mutation_p.P743S|ADAM29_ENST00000445694.1_Missense_Mutation_p.P743S	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	743	9 X 9 AA approximate repeats.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CCAGAGTCAACCTCCTGTGAC	0.527000													34	45					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101727002	101727002	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:101727002C>T	ENST00000251127.6	-	36	4047	c.3966G>A	c.(3964-3966)aaG>aaA	p.K1322K		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1322						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGAGGAGCATCTTTAGCGTTA	0.483000													16	24					0	0	1	0	0
TRIP4	9325	broad.mit.edu	37	15	64686287	64686287	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:64686287C>T	ENST00000261884.3	+	2	304	c.244C>T	c.(244-246)Cct>Tct	p.P82S	TRIP4_ENST00000559565.1_3'UTR	NM_016213.4	NP_057297.2	Q15650	TRIP4_HUMAN	thyroid hormone receptor interactor 4	82					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21						GATTTCGGATCCTTTGCAGCA	0.333000													12	9					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65252493	65252493	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:65252493C>T	ENST00000389722.3	-	16	3791	c.3738G>A	c.(3736-3738)aaG>aaA	p.K1246K	SPTB_ENST00000556626.1_Silent_p.K1246K|SPTB_ENST00000389720.3_Silent_p.K1246K|SPTB_ENST00000542895.1_Silent_p.K1246K|SPTB_ENST00000389721.5_Silent_p.K1246K	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1246					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GCACCTTCTCCTTGATCTTGT	0.572000													36	64					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227896959	227896959	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:227896959C>T	ENST00000396625.3	-	39	3818	c.3611G>A	c.(3610-3612)gGa>gAa	p.G1204E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1204E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1204	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCCAGGTATTCCCACTGGACC	0.507000													11	15					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5242241	5242241	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:5242241C>T	ENST00000274181.7	+	17	2737	c.2599C>T	c.(2599-2601)Cct>Tct	p.P867S		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	867	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						GAAGCAGCCCCCTGCCCAGCC	0.597000													37	42					0	0	1	0	0
TRBV11-1	28582	broad.mit.edu	37	7	142223982	142223982	+	RNA	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:142223982G>T	ENST00000390367.3	-	0	201																											CAGAAGCTCCGGGCCCTGTCC	0.478000													11	61					9.31168e-06	9.36351e-06	1	1	0
PHAX	51808	broad.mit.edu	37	5	125939354	125939354	+	Silent	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:125939354G>T	ENST00000297540.4	+	2	884	c.189G>T	c.(187-189)gtG>gtT	p.V63V	PHAX_ENST00000514725.1_3'UTR	NM_032177.3	NP_115553.2	Q9H814	PHAX_HUMAN	phosphorylated adaptor for RNA export	63	Necessary for interaction with CBP80 (By similarity).				ncRNA metabolic process|protein transport|snRNA export from nucleus|spliceosomal snRNP assembly	Cajal body|cytosol	RNA binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	8						TTGAAAGTGTGGATTCAAGTG	0.453000													38	65					1.60099e-16	1.62955e-16	1	1	0
CCNB3	85417	broad.mit.edu	37	X	50031800	50031800	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:50031800G>A	ENST00000376042.1	+	4	415	c.117G>A	c.(115-117)acG>acA	p.T39T	CCNB3_ENST00000348603.2_Silent_p.T39T|CCNB3_ENST00000376038.1_Silent_p.T39T|CCNB3_ENST00000276014.7_Silent_p.T39T			Q8WWL7	CCNB3_HUMAN	cyclin B3	39					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					ATTGCCAAACGAAGATATCTC	0.418000													6	12					0	0	1	0	0
CGB7	94027	broad.mit.edu	37	19	49557612	49557612	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:49557612G>A	ENST00000597853.1	-	5	3305	c.434C>T	c.(433-435)cCc>cTc	p.P145L	CGB7_ENST00000356213.4_Missense_Mutation_p.P143L|CGB7_ENST00000377280.3_Missense_Mutation_p.P145L|CGB7_ENST00000596965.1_Missense_Mutation_p.P145L					chorionic gonadotropin, beta polypeptide 7											lung(3)|urinary_tract(2)	5		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		AAGGCTGGGGGGAGGGGCCTT	0.642000													27	72					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152329028	152329028	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:152329028C>T	ENST00000388718.5	-	3	1306	c.1234G>A	c.(1234-1236)Gaa>Aaa	p.E412K	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	412	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGGAAAATTCATTTGAACTA	0.428000													20	83					0	0	1	0	0
IKBKAP	8518	broad.mit.edu	37	9	111665207	111665207	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr9:111665207G>T	ENST00000374647.5	-	16	2073	c.1766C>A	c.(1765-1767)gCt>gAt	p.A589D	IKBKAP_ENST00000537196.1_Missense_Mutation_p.A240D	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	589					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						TGGTTTAATAGCCAGAGAAGG	0.428000													3	8					6.4e-05	6.41776e-05	1	1	0
KIAA1462	57608	broad.mit.edu	37	10	30318031	30318031	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:30318031G>A	ENST00000375377.1	-	3	1147	c.1046C>T	c.(1045-1047)cCc>cTc	p.P349L		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	349	Pro-rich.									breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						GTTCTGCGGGGGCGATCTGTA	0.597000													75	9					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216298055	216298055	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:216298055G>A	ENST00000354785.4	-	3	776	c.407C>T	c.(406-408)aCc>aTc	p.T136I	FN1_ENST00000443816.1_Missense_Mutation_p.T136I|FN1_ENST00000421182.1_Missense_Mutation_p.T136I|FN1_ENST00000446046.1_Missense_Mutation_p.T136I|FN1_ENST00000345488.5_Missense_Mutation_p.T136I|FN1_ENST00000323926.6_Missense_Mutation_p.T136I|FN1_ENST00000359671.1_Missense_Mutation_p.T136I|FN1_ENST00000426059.1_Missense_Mutation_p.T136I|FN1_ENST00000346544.3_Missense_Mutation_p.T136I|FN1_ENST00000357009.2_Missense_Mutation_p.T136I|FN1_ENST00000356005.4_Missense_Mutation_p.T136I|FN1_ENST00000357867.4_Missense_Mutation_p.T136I|FN1_ENST00000336916.4_Missense_Mutation_p.T136I|FN1_ENST00000432072.2_Missense_Mutation_p.T136I			P02751	FINC_HUMAN	fibronectin 1	136	Fibrin- and heparin-binding 1.|Fibronectin type-I 2.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACTTGCGATGGTACAGCTTAT	0.443000													39	56					0	0	1	0	0
PRSS1	5644	broad.mit.edu	37	7	142459649	142459649	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:142459649G>A	ENST00000486171.1	+	4	284	c.267G>A	c.(265-267)gaG>gaA	p.E89E	PRSS1_ENST00000311737.7_Silent_p.E75E			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	75	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			GACTGGGAGAGCACAACATCG	0.562000													33	155					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154157625	154157625	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:154157625G>A	ENST00000360256.4	-	14	4640	c.4440C>T	c.(4438-4440)tcC>tcT	p.S1480S		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1480	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTGTCCCCAGGGAGCCAACCT	0.428000													21	48					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173506150	173506150	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:173506150C>T	ENST00000367714.3	-	14	2008	c.1586G>A	c.(1585-1587)gGa>gAa	p.G529E	SLC9C2_ENST00000466087.1_5'UTR|SLC9C2_ENST00000536496.1_Missense_Mutation_p.G427E	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	529					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										TTCAAGAATTCCATTGTTACG	0.313000													42	40					0	0	1	0	0
ZNF223	7766	broad.mit.edu	37	19	44570657	44570657	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:44570657C>T	ENST00000591793.1	+	7	1089	c.1006C>T	c.(1006-1008)Cat>Tat	p.H336Y	ZNF223_ENST00000434772.3_Missense_Mutation_p.H226Y			Q9UK11	ZN223_HUMAN	zinc finger protein 223	226				T -> M (in Ref. 1; AAF04105).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18		Prostate(69;0.0352)				TCAGAGAGTCCATACTGGAGA	0.418000													48	34					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75442073	75442073	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:75442073C>T	ENST00000549446.1	-	4	2320	c.1640G>A	c.(1639-1641)gGa>gAa	p.G547E	KCNC2_ENST00000341669.3_Missense_Mutation_p.G547E|KCNC2_ENST00000550433.1_Missense_Mutation_p.G547E|KCNC2_ENST00000393288.2_Missense_Mutation_p.G547E|KCNC2_ENST00000540018.1_Intron|KCNC2_ENST00000350228.2_Intron|KCNC2_ENST00000298972.1_Missense_Mutation_p.G547E|KCNC2_ENST00000548513.1_Missense_Mutation_p.G547E|KCNC2_ENST00000548243.1_Intron	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	547					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						CGGCTCACTTCCTGTACTGTC	0.478000													18	27					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35957378	35957378	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:35957378C>T	ENST00000274278.3	-	5	1344	c.987G>A	c.(985-987)tgG>tgA	p.W329*	UGT3A1_ENST00000513233.1_5'UTR|UGT3A1_ENST00000507113.1_Nonsense_Mutation_p.W295*|UGT3A1_ENST00000503189.1_Nonsense_Mutation_p.W329*	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	329						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCTGACATGTCCATATCACTC	0.502000													21	19					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263017	248263017	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:248263017C>T	ENST00000366478.2	+	3	677	c.340C>T	c.(340-342)Ctg>Ttg	p.L114L	OR2L13_ENST00000358120.2_Silent_p.L114L	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			AGGCTTACTCCTGACCTCCAT	0.507000													78	103					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101944443	101944443	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:101944443G>A	ENST00000251127.6	-	9	1026	c.945C>T	c.(943-945)aaC>aaT	p.N315N	NALCN_ENST00000376196.3_Silent_p.N315N|NALCN_ENST00000470333.1_5'UTR	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	315						integral to membrane	sodium channel activity|voltage-gated ion channel activity	p.N315K(1)		NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CAATAAACACGTTCTGAAAAA	0.398000													12	8					0	0	1	0	0
C17orf74	201243	broad.mit.edu	37	17	7329866	7329866	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:7329866G>A	ENST00000333870.3	+	3	630	c.556G>A	c.(556-558)Gag>Aag	p.E186K	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000574034.1_Missense_Mutation_p.G73E	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	186						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				TTCCTACCTGGAGGAGGAGGA	0.582000													20	11					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													3	67					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558444	140558444	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:140558444G>A	ENST00000239444.2	+	1	1074	c.829G>A	c.(829-831)Gag>Aag	p.E277K		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		277	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTCAACGGAGAGATTTCCTA	0.423000													42	5					0	0	1	0	0
LIMK2	3985	broad.mit.edu	37	22	31656058	31656058	+	Silent	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:31656058G>T	ENST00000331728.4	+	5	660	c.546G>T	c.(544-546)gtG>gtT	p.V182V	LIMK2_ENST00000406516.1_Silent_p.V104V|LIMK2_ENST00000340552.4_Silent_p.V161V|LIMK2_ENST00000444929.2_Intron|LIMK2_ENST00000333611.4_Silent_p.V161V	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	182	PDZ.					mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						CTGTGCAAGTGAAAGAGTAAG	0.552000													19	38					1.01871e-10	1.03301e-10	1	1	0
EPHA7	2045	broad.mit.edu	37	6	93979369	93979369	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:93979369C>T	ENST00000369303.4	-	7	1643	c.1459G>A	c.(1459-1461)Gaa>Aaa	p.E487K		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	487	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TAGGTCCGTTCCCTTTGATCC	0.363000													10	33					0	0	1	0	0
BCL3	602	broad.mit.edu	37	19	45262726	45262726	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:45262726C>A	ENST00000164227.5	+	9	1463	c.1219C>A	c.(1219-1221)Ccc>Acc	p.P407T		NM_005178.4	NP_005169.2	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	407	Pro/Ser-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				CTCCCAGTCTCCCCCCAGGGA	0.627000			T	IGH@	CLL								168	109					7.7851e-62	7.96136e-62	1	1	0
NXF1	10482	broad.mit.edu	37	11	62569260	62569260	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:62569260G>A	ENST00000531709.2	-	6	703	c.590C>T	c.(589-591)cCc>cTc	p.P197L	NXF1_ENST00000531131.1_5'UTR|NXF1_ENST00000532297.1_Missense_Mutation_p.P197L|NXF1_ENST00000439713.2_Missense_Mutation_p.P197L|NXF1_ENST00000294172.2_Missense_Mutation_p.P197L	NM_001081491.1	NP_001074960.1	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1	197	Interaction with THOC4.|RRM.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TATAGTGTGGGGTGGAGCAGA	0.468000													31	34					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7188218	7188218	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:7188218G>A	ENST00000542285.1	-	11	1729	c.1580C>T	c.(1579-1581)cCt>cTt	p.P527L				P00736	C1R_HUMAN	complement component 1, r subcomponent	579	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ATCGTTGTCAGGGAGGCAGAT	0.552000													7	12					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40376709	40376709	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:40376709T>G	ENST00000221347.6	-	24	11720	c.11713A>C	c.(11713-11715)Agc>Cgc	p.S3905R		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	3905						extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGGATGTTGCTGCAGAGAATG	0.587000													11	135					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1440092	1440092	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:1440092C>T	ENST00000345913.4	+	5	509	c.418C>T	c.(418-420)Cca>Tca	p.P140S	TPO_ENST00000329066.4_Missense_Mutation_p.P140S|TPO_ENST00000337415.3_Missense_Mutation_p.P140S|TPO_ENST00000382201.3_Missense_Mutation_p.P140S|TPO_ENST00000382269.3_Missense_Mutation_p.P140S|TPO_ENST00000346956.3_Missense_Mutation_p.P140S|TPO_ENST00000349624.3_Missense_Mutation_p.P140S|TPO_ENST00000382198.1_Missense_Mutation_p.P140S|TPO_ENST00000497517.2_Intron|TPO_ENST00000539820.1_Missense_Mutation_p.P140S	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	140					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CATGCTGCCCCCAAAATGCCC	0.433000													27	9					0	0	1	0	0
MIR1197	100302250	broad.mit.edu	37	14	101491960	101491960	+	RNA	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:101491960G>A	ENST00000408818.1	+	0	60					NR_031713.1																						TGTGACGTAGGACACATGGTC	0.498000													22	4					0	0	1	0	0
HHLA2	11148	broad.mit.edu	37	3	108073996	108073996	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:108073996G>A	ENST00000357759.5	+	5	867	c.453G>A	c.(451-453)agG>agA	p.R151R	HHLA2_ENST00000467761.1_Silent_p.R151R|HHLA2_ENST00000491820.1_Silent_p.R151R|HHLA2_ENST00000489514.2_Silent_p.R151R|HHLA2_ENST00000467562.1_Silent_p.R87R	NM_007072.2	NP_009003.1	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	151	Ig-like C1-type.					integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						ATGAAAAGAGGAACACAAACA	0.413000													6	17					0	0	1	0	0
TBX6	6911	broad.mit.edu	37	16	30099910	30099910	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:30099910A>T	ENST00000553607.1	-	5	1488	c.795T>A	c.(793-795)aaT>aaA	p.N265K	TBX6_ENST00000395224.2_Missense_Mutation_p.N265K|TBX6_ENST00000279386.2_Missense_Mutation_p.N265K			O95947	TBX6_HUMAN	T-box 6	265					anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	9						TGGCAAAGGGATTGGCTGCAA	0.502000													57	73					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151846058	151846058	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:151846058G>A	ENST00000355193.2	-	53	13343	c.13125C>T	c.(13123-13125)gtC>gtT	p.V4375V	KMT2C_ENST00000262189.6_Silent_p.V4318V					lysine (K)-specific methyltransferase 2C																		GCTTGGCCTCGACTTGGGCTG	0.552000													23	20					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108405367	108405367	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:108405367C>T	ENST00000361582.3	+	28	3315	c.3085C>T	c.(3085-3087)Ccc>Tcc	p.P1029S	DZIP3_ENST00000463306.1_Missense_Mutation_p.P1029S	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	1029					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						GCGGAGTGATCCCTCCATCAT	0.517000													66	44					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255646	140255646	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:140255646C>T	ENST00000398631.2	+	1	589	c.589C>T	c.(589-591)Cgg>Tgg	p.R197W	PCDHA5_ENST00000529859.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTAGTTCTTCGGAAGTTATT	0.348000													19	0					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99509726	99509726	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:99509726G>A	ENST00000261037.3	+	4	580	c.200G>A	c.(199-201)gGc>gAc	p.G67D	COL8A1_ENST00000273342.4_Missense_Mutation_p.G67D	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	67	Nonhelical region (NC2).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GCCAAAGATGGCCTTGCCATG	0.527000													12	43					0	0	1	0	0
FAM86EP	348926	broad.mit.edu	37	4	3948534	3948534	+	RNA	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:3948534G>A	ENST00000281228.8	-	0	851				FAM86EP_ENST00000313946.8_RNA																							TGTGGGTTGTGGACGGTAAAG	0.657000													35	51					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138583857	138583857	+	Missense_Mutation	SNP	G	G	A	rs149573553	by1000genomes	TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:138583857G>A	ENST00000251691.4	+	12	1403	c.1237G>A	c.(1237-1239)Gaa>Aaa	p.E413K		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	413			E -> D (in dbSNP:rs9376338).		regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		TGGCATGACCGAAGCATGCAT	0.473000													14	30					0	0	1	0	0
AK5	26289	broad.mit.edu	37	1	77987620	77987620	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:77987620G>T	ENST00000344720.5	+	12	2368	c.1342G>T	c.(1342-1344)Gga>Tga	p.G448*	AK5_ENST00000354567.2_Nonsense_Mutation_p.G474*	NM_012093.3	NP_036225.2	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5	474					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|prostate(1)|skin(2)|stomach(1)	40						GGAAGAGTTCGGACGCAGGGT	0.527000													6	7					2.0095e-06	2.02256e-06	1	1	0
KCNMB4	27345	broad.mit.edu	37	12	70760539	70760539	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:70760539G>A	ENST00000258111.4	+	1	484	c.25G>A	c.(25-27)Gag>Aag	p.E9K		NM_014505.5	NP_055320.4	Q86W47	KCMB4_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 4	9					detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of neurotransmitter secretion|regulation of vasoconstriction|synaptic transmission	voltage-gated potassium channel complex	calcium-activated potassium channel activity|protein binding			kidney(1)|large_intestine(4)|lung(5)	10	Renal(347;0.236)		Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			GGTGGCTTACGAGTACACGGA	0.692000													3	30					0	0	1	0	0
PPIL2	23759	broad.mit.edu	37	22	22040815	22040815	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:22040815C>T	ENST00000406385.1	+	11	818	c.758C>T	c.(757-759)aCc>aTc	p.T253I	PPIL2_ENST00000335025.7_Missense_Mutation_p.T253I|PPIL2_ENST00000492445.2_Missense_Mutation_p.T253I|PPIL2_ENST00000412327.1_Missense_Mutation_p.T253I|PPIL2_ENST00000398831.3_Missense_Mutation_p.T253I|PPIL2_ENST00000456792.2_Missense_Mutation_p.T232I			Q13356	PPIL2_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 2	253					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					TTCACCTCCACCGCGATGGTC	0.627000													23	35					0	0	1	0	0
ZNF827	152485	broad.mit.edu	37	4	146823838	146823838	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:146823838C>T	ENST00000508784.1	-	2	800	c.573G>A	c.(571-573)tgG>tgA	p.W191*	ZNF827_ENST00000379448.4_Nonsense_Mutation_p.W191*|ZNF827_ENST00000513320.1_Intron			Q17R98	ZN827_HUMAN	zinc finger protein 827	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					TACCTTGATTCCATATAAAAC	0.522000													10	38					0	0	1	0	0
OR56A3	390083	broad.mit.edu	37	11	5968693	5968693	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:5968693C>T	ENST00000329564.6	+	1	124	c.117C>T	c.(115-117)ttC>ttT	p.F39F		NM_001003443.2	NP_001003443.2	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A, member 3	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(27)|stomach(1)|upper_aerodigestive_tract(1)	41		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCTCCTTTTCCTCTTGGCCG	0.592000													15	26					0	0	1	0	0
OR51Q1	390061	broad.mit.edu	37	11	5444196	5444196	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:5444196C>T	ENST00000300778.4	+	1	856	c.766C>T	c.(766-768)Ccc>Tcc	p.P256S	HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|AC104389.28_ENST00000415970.1_RNA	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTCTACATTCCCATGGTTGG	0.517000													19	21					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767609	77767609	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:77767609G>A	ENST00000521891.2	+	10	8900	c.8452G>A	c.(8452-8454)Gag>Aag	p.E2818K	ZFHX4_ENST00000455469.2_Missense_Mutation_p.E2773K|ZFHX4_ENST00000518282.1_Missense_Mutation_p.E2792K|ZFHX4_ENST00000050961.6_Missense_Mutation_p.E2773K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2773						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CACCGGAGACGAGGGAAACAC	0.478000										HNSCC(33;0.089)			19	16					0	0	1	0	0
SLC7A10	56301	broad.mit.edu	37	19	33706862	33706862	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:33706862C>T	ENST00000253188.3	-	2	315	c.169G>A	c.(169-171)Ggc>Agc	p.G57S		NM_019849.2	NP_062823.1	Q9NS82	AAA1_HUMAN	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10	57					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	18	Esophageal squamous(110;0.137)					ATGAAGATGCCCGAGCCGATG	0.677000													4	4					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57175663	57175663	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:57175663C>T	ENST00000537055.2	-	2	1135	c.904G>A	c.(904-906)Ggc>Agc	p.G302S		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						GGCTTCTCGCCCGTGTGCACG	0.701000													7	11					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10304634	10304634	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:10304634G>A	ENST00000403437.2	-	24	3160	c.3066C>T	c.(3064-3066)atC>atT	p.I1022I	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1022					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CTTTGGTCAGGATGTTGACTT	0.403000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				55	53					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139856381	139856381	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:139856381G>A	ENST00000303045.6	-	4	1125	c.679C>T	c.(679-681)Cgt>Tgt	p.R227C	COL22A1_ENST00000435777.1_Missense_Mutation_p.R227C	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	227					cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCTTCTACACGAACGCTAGGA	0.448000										HNSCC(7;0.00092)			51	76					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156590578	156590578	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:156590578C>T	ENST00000302938.4	-	2	793	c.698G>A	c.(697-699)gGg>gAg	p.G233E		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	233	Ala-rich.					nucleus		p.G233A(1)		NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCCCTCTCCCCCAGCATAAGC	0.572000													37	11					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3886440	3886440	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:3886440G>A	ENST00000319331.3	+	2	876	c.115G>A	c.(115-117)Gaa>Aaa	p.E39K	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	39	LRRNT.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TTGCGTATGTGAAATTCGTCC	0.453000													30	21					0	0	1	0	0
IQSEC2	23096	broad.mit.edu	37	X	53284082	53284082	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:53284082G>A	ENST00000396435.3	-	4	1231	c.1031C>T	c.(1030-1032)tCc>tTc	p.S344F	IQSEC2_ENST00000375365.2_Missense_Mutation_p.S139F|IQSEC2_ENST00000375368.5_Missense_Mutation_p.S334F	NM_001111125.2	NP_001104595.1	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2	334	IQ.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(4)|skin(1)	29						GCTCAGGAAGGAGCCCCCATA	0.587000													6	10					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132021632	132021632	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:132021632G>A	ENST00000356920.5	+	15	2698	c.2604G>A	c.(2602-2604)ggG>ggA	p.G868G	PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron|POTEE_ENST00000358087.5_3'UTR	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	868	Actin-like.						ATP binding										TCTATGAGGGGAATGCCCTCC	0.617000													13	63					0	0	1	0	0
CIDEB	27141	broad.mit.edu	37	14	24776628	24776628	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:24776628C>T	ENST00000336557.5	-	5	1437	c.135G>A	c.(133-135)cgG>cgA	p.R45R	CIDEB_ENST00000258807.5_Silent_p.R45R|CIDEB_ENST00000554411.1_Silent_p.R45R|NOP9_ENST00000267425.3_3'UTR			Q9UHD4	CIDEB_HUMAN	cell death-inducing DFFA-like effector b	45	CIDE-N.				apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis	cytosol				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|urinary_tract(1)	7				GBM - Glioblastoma multiforme(265;0.0181)		TCCGGATGGTCCGCTTGTGAT	0.577000													39	5					0	0	1	0	0
HKR1	284459	broad.mit.edu	37	19	37854364	37854364	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:37854364G>A	ENST00000591471.1	+	9	2489	c.848G>A	c.(847-849)aGg>aAg	p.R283K	HKR1_ENST00000589392.1_Missense_Mutation_p.R538K|HKR1_ENST00000591134.1_Intron|HKR1_ENST00000392153.3_Missense_Mutation_p.R537K|HKR1_ENST00000541583.2_Missense_Mutation_p.R495K|HKR1_ENST00000324411.4_Missense_Mutation_p.R556K|HKR1_ENST00000544914.1_Missense_Mutation_p.R283K			P10072	HKR1_HUMAN	HKR1, GLI-Kruppel zinc finger family member	556					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTATGTGCAGGGAGTGTGGC	0.502000													9	21					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79324803	79324803	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr9:79324803G>A	ENST00000428286.1	-	8	2510	c.1310C>T	c.(1309-1311)cCa>cTa	p.P437L	PRUNE2_ENST00000376718.3_Missense_Mutation_p.P796L			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	796					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GGCTGGGAATGGCGCCACAGC	0.498000													10	1					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50958831	50958831	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:50958831G>A	ENST00000357701.5	+	20	2319	c.2268G>A	c.(2266-2268)aaG>aaA	p.K756K		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	756	Fibronectin type-III 2.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CCACACTCAAGTGGAGGCCTC	0.592000													23	41					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372221	126372221	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:126372221G>A	ENST00000394329.3	+	9	10063	c.10050G>A	c.(10048-10050)aaG>aaA	p.K3350K	FAT4_ENST00000335110.5_Silent_p.K1648K	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3350	Cadherin 32.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGATCAATAAGAAGACTGGAC	0.413000													39	32					0	0	1	0	0
RPL13AP3	645683	broad.mit.edu	37	14	56232973	56232973	+	RNA	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:56232973T>C	ENST00000554458.1	+	0	75				RPL13AP3_ENST00000494676.1_RNA																							GGCTAAGTAGTTACTGCTGGG	0.582000													7	1					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9048215	9048215	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:9048215G>A	ENST00000397910.4	-	5	33619	c.33416C>T	c.(33415-33417)tCa>tTa	p.S11139L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11141	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.S11139*(1)|p.S6772*(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TAGAACAGCTGAGCTGGCTTC	0.468000													23	29					0	0	1	0	0
CLDN10	9071	broad.mit.edu	37	13	96086220	96086220	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:96086220C>T	ENST00000376873.3	+	1	363	c.133C>T	c.(133-135)Cag>Tag	p.Q45*		NM_001160100.1|NM_182848.3	NP_001153572.1|NP_878268.1	P78369	CLD10_HUMAN	claudin 10	47					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			TTGGGTTTACCAGGGTCTGTG	0.507000													12	38					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95110999	95110999	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:95110999C>T	ENST00000371501.4	-	35	3998	c.3876G>A	c.(3874-3876)atG>atA	p.M1292I	MYOF_ENST00000359263.4_Missense_Mutation_p.M1292I|MYOF_ENST00000371502.4_Missense_Mutation_p.M1292I|MYOF_ENST00000358334.5_Missense_Mutation_p.M1279I			Q9NZM1	MYOF_HUMAN	myoferlin	1292					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						CCTGGGGGACCATGTATAGAT	0.507000													24	2					0	0	1	0	0
SMO	6608	broad.mit.edu	37	7	128851581	128851581	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:128851581G>A	ENST00000249373.3	+	11	2186	c.1906G>A	c.(1906-1908)Gat>Aat	p.D636N	RP11-286H14.8_ENST00000466717.1_RNA	NM_005631.4	NP_005622.1	Q99835	SMO_HUMAN	smoothened, frizzled family receptor	636					adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						ACTGCCCCAGGATATTTCTGT	0.582000			Mis		skin basal cell								25	89					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102743697	102743697	+	RNA	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:102743697G>A	ENST00000532855.1	-	0	344							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	CATCTCCAGGGTAGATGTGTC	0.468000													4	10					0	0	1	0	0
OR1A1	8383	broad.mit.edu	37	17	3119100	3119100	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:3119100C>T	ENST00000304094.1	+	1	186	c.186C>T	c.(184-186)ctC>ctT	p.L62L		NM_014565.2	NP_055380.2	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A, member 1	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	23						TGTATTTTCTCCTTGCCAACC	0.473000													49	100					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155823530	155823530	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:155823530G>A	ENST00000437809.1	-	2	164	c.42C>T	c.(40-42)tcC>tcT	p.S14S	GON4L_ENST00000271883.5_Silent_p.S14S|GON4L_ENST00000361040.5_Silent_p.S14S|GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000368331.1_Silent_p.S14S			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	14					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TATGCTGTAGGGACTCTGTCA	0.398000													22	30					0	0	1	0	0
GPX5	2880	broad.mit.edu	37	6	28501787	28501787	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:28501787C>T	ENST00000412168.2	+	5	598	c.509C>T	c.(508-510)tCc>tTc	p.S170F	GPX5_ENST00000442674.2_3'UTR|GPX5_ENST00000469384.1_3'UTR	NM_001509.2	NP_001500.1	O75715	GPX5_HUMAN	glutathione peroxidase 5 (epididymal androgen-related protein)	170					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			endometrium(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16					Glutathione(DB00143)	AAATCTATATCCTGGGACCCT	0.493000													24	139					0	0	1	0	0
FRMD7	90167	broad.mit.edu	37	X	131212172	131212172	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:131212172C>T	ENST00000298542.4	-	12	2048	c.1873G>A	c.(1873-1875)Gat>Aat	p.D625N	FRMD7_ENST00000464296.1_Missense_Mutation_p.D610N|FRMD7_ENST00000370879.1_Missense_Mutation_p.D505N	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	625					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					GCAAACATATCCGTAAACAGG	0.423000													45	37					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144835114	144835114	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:144835114G>A	ENST00000367545.3	+	35	5014	c.5014G>A	c.(5014-5016)Gaa>Aaa	p.E1672K		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1672	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TTATCAAGCTGAAGCTCTATT	0.373000													14	13					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130319381	130319381	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:130319381C>T	ENST00000299164.2	+	1	513	c.513C>T	c.(511-513)acC>acT	p.T171T		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	171					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GAGACCCCACCTCTCGCTGCG	0.746000													6	4					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85461792	85461792	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:85461792C>T	ENST00000394573.1	+	10	1035	c.833C>T	c.(832-834)tCc>tTc	p.S278F	SLC28A1_ENST00000537624.1_Missense_Mutation_p.S278F|SLC28A1_ENST00000537703.1_Missense_Mutation_p.S200F|SLC28A1_ENST00000538177.1_Missense_Mutation_p.S278F|SLC28A1_ENST00000286749.3_Missense_Mutation_p.S278F|SLC28A1_ENST00000537216.1_Missense_Mutation_p.S278F	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	278					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGTGTCATATCCGTTCTCTAC	0.582000													46	48					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2876014	2876014	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:2876014C>T	ENST00000520002.1	-	53	8572	c.8017G>A	c.(8017-8019)Gaa>Aaa	p.E2673K	CSMD1_ENST00000537824.1_Missense_Mutation_p.E2672K|CSMD1_ENST00000602723.1_Intron|CSMD1_ENST00000602557.1_Missense_Mutation_p.E2673K|CSMD1_ENST00000542608.1_Intron|CSMD1_ENST00000400186.3_Intron			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2673	Sushi 17.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CATCGAGTTTCGCTGCCGCTC	0.458000													50	107					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169698418	169698418	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:169698418G>A	ENST00000333360.7	-	7	1138	c.999C>T	c.(997-999)ttC>ttT	p.F333F	SELE_ENST00000367781.4_Silent_p.F333F|SELE_ENST00000367775.1_Silent_p.F271F|SELE_ENST00000367779.4_Silent_p.F333F|SELE_ENST00000367777.1_Silent_p.F333F|SELE_ENST00000367776.1_Silent_p.F333F|SELE_ENST00000367780.4_Silent_p.F271F|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367782.4_Silent_p.F333F|SELE_ENST00000367774.1_Silent_p.F333F	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	333	Sushi 3.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					CCTCACAGGTGAAGTTGCAGG	0.552000													8	16					0	0	1	0	0
CEP55	55165	broad.mit.edu	37	10	95259876	95259876	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:95259876C>T	ENST00000371485.3	+	2	372	c.68C>T	c.(67-69)tCc>tTc	p.S23F		NM_001127182.1|NM_018131.4	NP_001120654.1|NP_060601.3	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	23					cell division|mitosis	centriole|cleavage furrow|midbody				kidney(1)|large_intestine(5)|lung(6)|stomach(1)	13		Colorectal(252;0.207)				AACTCCAAATCCGAAACTACA	0.348000													50	11					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7494314	7494314	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:7494314G>A	ENST00000486284.1	+	6	1469	c.1195G>A	c.(1195-1197)Gat>Aat	p.D399N	GRM7_ENST00000357716.4_Missense_Mutation_p.D399N|GRM7_ENST00000403881.1_Missense_Mutation_p.D399N|GRM7_ENST00000389336.4_Missense_Mutation_p.D399N|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000402647.2_Missense_Mutation_p.D399N	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	399					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding	p.D399Y(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	AATTGGAAAAGATTCCAACTA	0.433000													20	10					0	0	1	0	0
ZNF732	654254	broad.mit.edu	37	4	265490	265490	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:265490C>T	ENST00000419098.1	-	4	1166	c.1156G>A	c.(1156-1158)Gga>Aga	p.G386R		NM_001137608.1	NP_001131080.1	B4DXR9	ZN732_HUMAN	zinc finger protein 732	386					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(2)	3						GGTTTCTCTCCAGTATGAATA	0.403000													9	8					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626906	108626906	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:108626906C>T	ENST00000264047.2	+	9	1608	c.1332C>T	c.(1330-1332)ttC>ttT	p.F444F	SLC5A7_ENST00000409059.1_Silent_p.F444F|SLC5A7_ENST00000540517.1_Silent_p.F339F	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	444					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	CTGGCCTCTTCCTGAGAATAA	0.443000													32	34					0	0	1	0	0
ST6GALNAC3	256435	broad.mit.edu	37	1	76877879	76877879	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:76877879C>T	ENST00000328299.3	+	3	548	c.400C>T	c.(400-402)Cct>Tct	p.P134S	ST6GALNAC3_ENST00000464140.1_3'UTR	NM_152996.2	NP_694541.2	Q8NDV1	SIA7C_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	134					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|ovary(3)|prostate(1)|skin(2)	36						TACCAGCGTTCCTCTTTTGCT	0.428000													44	23					0	0	1	0	0
C1QTNF7	114905	broad.mit.edu	37	4	15443999	15443999	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:15443999C>T	ENST00000295297.4	+	3	726	c.467C>T	c.(466-468)gCc>gTc	p.A156V	C1QTNF7_ENST00000429690.1_Missense_Mutation_p.A149V|C1QTNF7_ENST00000444304.2_Missense_Mutation_p.A149V	NM_001135170.1	NP_001128642.1	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	149	C1q.					collagen				endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)	16						CTCAAATCCGCCTTTTCTGTT	0.517000													112	167					0	0	1	0	0
PBXIP1	57326	broad.mit.edu	37	1	154920159	154920159	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:154920159G>A	ENST00000368463.3	-	8	768	c.697C>T	c.(697-699)Ctc>Ttc	p.L233F	PBXIP1_ENST00000498553.1_5'UTR|PBXIP1_ENST00000368465.1_Missense_Mutation_p.L204F|PBXIP1_ENST00000542459.1_Missense_Mutation_p.L78F|PBXIP1_ENST00000539880.1_Missense_Mutation_p.L60F|PBXIP1_ENST00000368460.3_Missense_Mutation_p.L202F	NM_020524.2	NP_065385.2	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein 1	233					cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			breast(1)|kidney(2)|large_intestine(6)|lung(13)|prostate(1)|urinary_tract(1)	24	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGGTCTGGGAGGACCTGCCGC	0.627000													35	54					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103121876	103121876	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:103121876A>T	ENST00000295269.4	+	4	1601	c.1144A>T	c.(1144-1146)Aac>Tac	p.N382Y		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	382					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						TCACGAGTGGAACTGGGCCTT	0.537000													32	36					0	0	1	0	0
GAS2L1	10634	broad.mit.edu	37	22	29704337	29704337	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:29704337C>T	ENST00000471961.1	+	1	1290	c.242C>T	c.(241-243)cCg>cTg	p.P81L	GAS2L1_ENST00000341313.6_Missense_Mutation_p.P81L|GAS2L1_ENST00000360113.2_Missense_Mutation_p.P81L|GAS2L1_ENST00000406549.3_Missense_Mutation_p.P81L|GAS2L1_ENST00000407647.2_Missense_Mutation_p.P81L|GAS2L1_ENST00000403764.1_Missense_Mutation_p.P81L|GAS2L1_ENST00000407854.1_Missense_Mutation_p.P81L			Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1	81	CH.				cell cycle arrest	cytoplasm|cytoskeleton				endometrium(2)|lung(2)|prostate(1)	5						GCCGCCCGCCCGGCCCGAGGT	0.697000													14	12					0	0	1	0	0
KRTAP10-10	353333	broad.mit.edu	37	21	46057511	46057511	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr21:46057511C>T	ENST00000380095.1	+	1	239	c.177C>T	c.(175-177)ccC>ccT	p.P59P	TSPEAR_ENST00000323084.4_Intron	NM_181688.1	NP_859016.1	P60014	KR10A_HUMAN	keratin associated protein 10-10	59	15 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(2)|kidney(1)|lung(6)|prostate(1)|skin(2)	13						CCTGTGAGCCCAGCGCCTGCC	0.672000													58	32					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63489391	63489391	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:63489391G>A	ENST00000536984.2	+	5	1394	c.700G>A	c.(700-702)Gat>Aat	p.D234N	CDH7_ENST00000323011.3_Missense_Mutation_p.D234N|CDH7_ENST00000397968.2_Missense_Mutation_p.D234N			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	234	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				TCAGGCAAAGGATATGGTTGG	0.423000													23	11					0	0	1	0	0
CEP128	145508	broad.mit.edu	37	14	81251578	81251578	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:81251578G>A	ENST00000555265.1	-	15	2247	c.1872C>T	c.(1870-1872)gcC>gcT	p.A624A	CEP128_ENST00000281129.3_Silent_p.A624A			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	624						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						CTTTGTCCTGGGCCTGGCTCT	0.463000													44	9					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82876184	82876184	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:82876184G>A	ENST00000265077.3	+	15	10687	c.10122G>A	c.(10120-10122)aaG>aaA	p.K3374K	VCAN_ENST00000512590.2_Silent_p.K1572K|VCAN_ENST00000502527.2_Silent_p.K633K|VCAN_ENST00000343200.5_Silent_p.K2387K|VCAN_ENST00000342785.4_Silent_p.K1620K|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000513016.1_3'UTR	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	3374					cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CATCAGCAAAGGACAATTCAA	0.383000													25	27					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16253384	16253384	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:16253384G>A	ENST00000205557.7	-	26	3719	c.3690C>T	c.(3688-3690)atC>atT	p.I1230I		NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	1230					response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CCACTGACACGATGCTGTTCT	0.607000													16	22					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46915326	46915326	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:46915326G>A	ENST00000307522.3	-	1	1515	c.742C>T	c.(742-744)Cgc>Tgc	p.R248C		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	248						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		TTTCCCAAGCGATCCCCCGGG	0.706000													17	38					0	0	1	0	0
TF	7018	broad.mit.edu	37	3	133473407	133473407	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:133473407C>T	ENST00000402696.3	+	4	879	c.394C>T	c.(394-396)Cga>Tga	p.R132*	TF_ENST00000264998.3_Nonsense_Mutation_p.R5*|TF_ENST00000475382.1_3'UTR|TFP1_ENST00000460564.1_RNA	NM_001063.3	NP_001054.1	P02787	TRFE_HUMAN	transferrin	132	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	GAACCAGCTTCGAGGCAAGAA	0.517000													42	105					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154625664	154625664	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:154625664C>T	ENST00000260010.6	+	1	3013	c.1605C>T	c.(1603-1605)ttC>ttT	p.F535F		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	535					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				GCAATAACTTCATTTGCTCCT	0.433000													16	28					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61600336	61600336	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:61600336C>T	ENST00000238508.3	+	7	747	c.688C>T	c.(688-690)Cac>Tac	p.H230Y		NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				TCACATTTTTCACATAGAAAA	0.373000													27	18					0	0	1	0	0
PEF1	553115	broad.mit.edu	37	1	32101024	32101024	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:32101024G>A	ENST00000373703.4	-	2	146	c.124C>T	c.(124-126)Cct>Tct	p.P42S	PEF1_ENST00000492061.1_5'UTR|PEF1_ENST00000440872.2_Missense_Mutation_p.P42S	NM_012392.3	NP_036524.1	Q9UBV8	PEF1_HUMAN	penta-EF-hand domain containing 1	42	9 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-P.				response to calcium ion	cytoplasm|membrane	calcium ion binding|protein heterodimerization activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(2)|upper_aerodigestive_tract(1)	7		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)|all_neural(195;0.186)		STAD - Stomach adenocarcinoma(196;0.0546)		CCACCACCAGGGGGTAGCCCA	0.647000													7	11					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973502	29973502	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:29973502G>A	ENST00000378993.1	+	11	2329	c.1656G>A	c.(1654-1656)tgG>tgA	p.W552*	IL1RAPL1_ENST00000302196.4_Nonsense_Mutation_p.W552*	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	552	Interaction with NCS1.|TIR.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						CCAAGTTCTGGAAACGTTTAC	0.468000													11	13					0	0	1	0	0
GIMAP7	168537	broad.mit.edu	37	7	150217482	150217482	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:150217482G>A	ENST00000313543.4	+	2	577	c.420G>A	c.(418-420)caG>caA	p.Q140Q		NM_153236.3	NP_694968.1	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	140							GTP binding			breast(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	17			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGAGGGCCAGAGCTTCCATG	0.502000													13	25					0	0	1	0	0
RFT1	91869	broad.mit.edu	37	3	53126614	53126614	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:53126614G>A	ENST00000296292.3	-	12	1290	c.1229C>T	c.(1228-1230)gCc>gTc	p.A410V	RP11-894J14.5_ENST00000607203.1_Intron|RFT1_ENST00000394738.3_Missense_Mutation_p.A371V	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	410					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		GGAGGACAGGGCCAGCATCAC	0.542000													4	6					0	0	1	0	0
C6orf222	389384	broad.mit.edu	37	6	36287351	36287351	+	Missense_Mutation	SNP	C	C	T	rs138094812	byFrequency	TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:36287351C>T	ENST00000437635.2	-	11	1882	c.1705G>A	c.(1705-1707)Gag>Aag	p.E569K		NM_001010903.4	NP_001010903.3	P0C671	CF222_HUMAN	chromosome 6 open reading frame 222	569										breast(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(4)|urinary_tract(4)	26						TCCGAGAACTCGTAAAAAAAC	0.572000													10	66					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	95712378	95712378	+	Silent	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:95712378A>G	ENST00000524717.1	-	5	4489	c.3205T>C	c.(3205-3207)Ttg>Ctg	p.L1069L		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	1069					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				GACTGATTCAACCCTGTTCCT	0.502000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								11	15					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28762045	28762045	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:28762045G>A	ENST00000422425.2	+	11	775	c.731_splice	c.e11+1	p.S244_splice	PLB1_ENST00000327757.5_Splice_Site_p.S233_splice	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	233	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					ACTTGGCTCAGGTAAAAGGGG	0.562000													18	13					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103244871	103244871	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:103244871G>A	ENST00000428762.1	-	23	3227	c.3068C>T	c.(3067-3069)gCt>gTt	p.A1023V	RELN_ENST00000343529.5_Missense_Mutation_p.A1023V|RELN_ENST00000424685.2_Missense_Mutation_p.A1023V	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1023					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GCTGTCCAAAGCCCACTCGTC	0.502000													31	24					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211192334	211192334	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:211192334C>T	ENST00000367007.4	-	6	992	c.823G>A	c.(823-825)Gga>Aga	p.G275R	KCNH1_ENST00000271751.4_Missense_Mutation_p.G275R	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	275					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CCTGCTGGTCCAACAAAGGTG	0.453000													20	25					0	0	1	0	0
CCDC74B	91409	broad.mit.edu	37	2	130900019	130900019	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:130900019C>T	ENST00000392984.3	-	2	1280	c.537G>A	c.(535-537)cgG>cgA	p.R179R	CCDC74B_ENST00000310463.6_Intron|CCDC74B_ENST00000409943.3_Intron|CCDC74B_ENST00000409128.1_Intron			Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	161										endometrium(2)|large_intestine(1)|lung(3)	6	Colorectal(110;0.1)					TGGCCTCTTCCCGTGTCCTGT	0.632000													14	32					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92762118	92762118	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:92762118G>A	ENST00000318238.4	-	5	4383	c.3167C>T	c.(3166-3168)tCc>tTc	p.S1056F	SAMD9L_ENST00000411955.1_Missense_Mutation_p.S1056F|SAMD9L_ENST00000437805.1_Missense_Mutation_p.S1056F	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1056										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CATTAATGGGGAAAACAGAGT	0.393000													44	45					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76023637	76023637	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:76023637C>T	ENST00000393004.2	-	5	2132	c.1911G>A	c.(1909-1911)gaG>gaA	p.E637E	FILIP1_ENST00000370020.1_Silent_p.E538E|FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Silent_p.E637E			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	637										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TCTTCAGTCTCTCAATTTCAA	0.418000													52	70					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2813976	2813976	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:2813976C>T	ENST00000301740.8	+	11	3996	c.3447C>T	c.(3445-3447)gaC>gaT	p.D1149D		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	1149	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						CTACAGTGGACTCGAATTCTC	0.478000													13	57					0	0	1	0	0
PIK3C3	5289	broad.mit.edu	37	18	39647477	39647477	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:39647477G>A	ENST00000262039.4	+	24	2735	c.2649_splice	c.e24+1	p.Q883_splice	PIK3C3_ENST00000588156.1_Splice_Site_p.Q107_splice|PIK3C3_ENST00000593098.1_Splice_Site_p.Q368_splice|PIK3C3_ENST00000398870.3_Splice_Site_p.Q820_splice|PIK3C3_ENST00000587328.1_Splice_Site_p.Q61_splice	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	883	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						AGTTTGCCCAGGTAAGTTCCC	0.488000										TSP Lung(28;0.18)			4	17					0	0	1	0	0
B3GALTL	145173	broad.mit.edu	37	13	31850896	31850896	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:31850896C>T	ENST00000343307.4	+	10	987	c.838C>T	c.(838-840)Cat>Tat	p.H280Y	B3GALTL_ENST00000461652.2_3'UTR	NM_194318.3	NP_919299.3	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	280					fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			breast(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		CAAGAAATTTCATGGTGACAG	0.313000													7	20					0	0	1	0	0
ANKS4B	257629	broad.mit.edu	37	16	21261887	21261887	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:21261887G>A	ENST00000311620.5	+	2	1073	c.1000G>A	c.(1000-1002)Gat>Aat	p.D334N		NM_145865.2	NP_665872.2	Q8N8V4	ANS4B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 4B	334								p.D334N(1)		NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|lung(11)|ovary(2)	20				GBM - Glioblastoma multiforme(48;0.0565)		GTGGGATGACGATGAAGTGGA	0.517000													16	18					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53104185	53104185	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:53104185C>T	ENST00000408890.4	+	1	837	c.821C>T	c.(820-822)tCc>tTc	p.S274F		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	274										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						ACAACGCCTTCCTGCGGCAGC	0.637000													38	39					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179596941	179596941	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179596941C>T	ENST00000589042.1	-	57	16979	c.16755G>A	c.(16753-16755)aaG>aaA	p.K5585K	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Silent_p.K5268K|TTN_ENST00000342992.6_Silent_p.K4341K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5268	Ig-like 36.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCTGCTCTCCTTAATTTCTC	0.438000													52	63					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230456412	230456412	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:230456412G>A	ENST00000341772.4	-	2	603	c.469C>T	c.(469-471)Cct>Tct	p.P157S		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	157					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TGAGTAGCAGGAACAGGCTGA	0.552000													31	27					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10354108	10354108	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:10354108C>T	ENST00000255381.2	-	29	4080	c.3970G>A	c.(3970-3972)Gaa>Aaa	p.E1324K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1324					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GTCTCCTCTTCTAGCTGCCTC	0.388000													9	44					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89990063	89990063	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:89990063C>T	ENST00000405460.2	+	33	7586	c.7490C>T	c.(7489-7491)gCt>gTt	p.A2497V		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2497					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGTGGTCAGGCTGTGGCTGGG	0.468000													22	36					0	0	1	0	0
NAGA	4668	broad.mit.edu	37	22	42463799	42463799	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:42463799G>A	ENST00000396398.3	-	3	826	c.294C>T	c.(292-294)ttC>ttT	p.F98F	NAGA_ENST00000402937.1_Silent_p.F98F|NAGA_ENST00000403363.1_Silent_p.F98F	NM_000262.2	NP_000253.1	P17050	NAGAB_HUMAN	N-acetylgalactosaminidase, alpha-	98					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						TGCCATGAGGGAAGCGCTTGG	0.607000													30	51					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96706317	96706317	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:96706317G>A	ENST00000389672.5	+	3	632	c.594G>A	c.(592-594)atG>atA	p.M198I	EPHA6_ENST00000542517.1_Missense_Mutation_p.M104I|EPHA6_ENST00000470610.2_Missense_Mutation_p.M198I	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	103	Ephrin-binding.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						ATGTGGAAATGAAATTCACAC	0.403000													14	22					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183095762	183095762	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:183095762C>T	ENST00000435564.1	-	5	762	c.562G>A	c.(562-564)Gat>Aat	p.D188N	PDE1A_ENST00000536095.1_Missense_Mutation_p.D84N|PDE1A_ENST00000346717.4_Missense_Mutation_p.D154N|PDE1A_ENST00000456212.1_Missense_Mutation_p.D188N|PDE1A_ENST00000331935.6_Missense_Mutation_p.D188N|PDE1A_ENST00000358139.2_Missense_Mutation_p.D188N|PDE1A_ENST00000351439.5_Missense_Mutation_p.D172N|PDE1A_ENST00000409365.1_Missense_Mutation_p.D172N|PDE1A_ENST00000482538.1_5'UTR|PDE1A_ENST00000410103.1_Missense_Mutation_p.D188N	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	188					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.D188N(2)		endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TTGATAAGATCATATCTGGTA	0.338000													30	29					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155267673	155267673	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:155267673C>T	ENST00000460012.1	-	10	1532	c.1175G>A	c.(1174-1176)gGa>gAa	p.G392E	PLCH1_ENST00000494598.1_Missense_Mutation_p.G410E|PLCH1_ENST00000447496.2_Missense_Mutation_p.G410E|PLCH1_ENST00000334686.6_Missense_Mutation_p.G392E|PLCH1_ENST00000414191.1_Missense_Mutation_p.G392E|PLCH1_ENST00000340059.7_Missense_Mutation_p.G410E			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	410	PI-PLC X-box.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity	p.G392E(1)		NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCCGAATATTCCTTTCAGGTA	0.438000													5	24					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29231455	29231455	+	RNA	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:29231455C>T	ENST00000441381.1	+	0	79																											GTTGGGGGTTCATTATGGTCA	0.483000													27	151					0	0	1	0	0
TMEM106B	54664	broad.mit.edu	37	7	12258113	12258113	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:12258113C>T	ENST00000396667.2	+	4	569	c.247C>T	c.(247-249)Cca>Tca	p.P83S	TMEM106B_ENST00000396668.3_Missense_Mutation_p.P83S	NM_018374.3	NP_060844.2	Q9NUM4	T106B_HUMAN	transmembrane protein 106B	83						integral to membrane				NS(1)|endometrium(8)|large_intestine(2)|lung(7)	18				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)		GGCATTGATTCCATATAGTGA	0.308000													15	18					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72147103	72147103	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:72147103G>A	ENST00000305425.4	-	4	1596	c.1174C>T	c.(1174-1176)Cct>Tct	p.P392S	DACH1_ENST00000354591.4_Intron|DACH1_ENST00000359684.2_Missense_Mutation_p.P444S|DACH1_ENST00000313174.7_Intron	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	442					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AGGCTGACAGGAATTAGAGGG	0.438000													5	17					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151124224	151124224	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:151124224G>A	ENST00000370325.1	-	7	946	c.893C>T	c.(892-894)tCc>tTc	p.S298F	GABRE_ENST00000483564.1_5'UTR|GABRE_ENST00000370328.3_Missense_Mutation_p.S298F			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	298					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GATCCAAAAGGAAACCCAGGA	0.512000													51	64					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47402395	47402395	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:47402395G>A	ENST00000310638.4	-	4	482	c.451C>T	c.(451-453)Cac>Tac	p.H151Y	CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000457840.2_Missense_Mutation_p.H47Y|CYP4A11_ENST00000371905.1_Missense_Mutation_p.H151Y|CYP4A11_ENST00000371904.4_Missense_Mutation_p.H151Y	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	151					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	ATGTCATAGTGGAAGGCTGGG	0.542000													8	27					0	0	1	0	0
CYP2B6	1555	broad.mit.edu	37	19	41522698	41522698	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:41522698C>T	ENST00000324071.4	+	9	1449	c.1442C>T	c.(1441-1443)cCc>cTc	p.P481L	CYP2B6_ENST00000330446.5_Missense_Mutation_p.P281L|CYP2B6_ENST00000593831.1_Missense_Mutation_p.P245L	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	481					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	GGCAAAATACCCCCAACATAC	0.582000													3	27					0	0	1	0	0
CAPN2	824	broad.mit.edu	37	1	223940531	223940531	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:223940531C>T	ENST00000295006.5	+	9	1317	c.1008C>T	c.(1006-1008)tcC>tcT	p.S336S	CAPN2_ENST00000433674.2_Silent_p.S258S	NM_001748.4	NP_001739.2	P17655	CAN2_HUMAN	calpain 2, (m/II) large subunit	336	Calpain catalytic.				proteolysis	cytoplasm|plasma membrane				breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|stomach(3)	29				GBM - Glioblastoma multiforme(131;0.109)		GGCACTATTCCCGCCTGGAGA	0.507000													17	24					0	0	1	0	0
FAM81B	153643	broad.mit.edu	37	5	94756058	94756058	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:94756058A>G	ENST00000283357.5	+	5	654	c.608A>G	c.(607-609)aAc>aGc	p.N203S		NM_152548.2	NP_689761.2	Q96LP2	FA81B_HUMAN	family with sequence similarity 81, member B	203										central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		CACGAGATAAACATCAAACAC	0.403000													32	26					0	0	1	0	0
PIEZO2	63895	broad.mit.edu	37	18	10680264	10680264	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:10680264C>T	ENST00000302079.6	-	47	7355	c.7356G>A	c.(7354-7356)caG>caA	p.Q2452Q	PIEZO2_ENST00000538948.1_Silent_p.Q472Q|PIEZO2_ENST00000285141.4_Silent_p.Q307Q|PIEZO2_ENST00000580640.1_Silent_p.Q2540Q|PIEZO2_ENST00000503781.3_Silent_p.Q2515Q|PIEZO2_ENST00000581680.1_Intron			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2515						integral to membrane	ion channel activity										GTATCATTTTCTGCTTACTGG	0.378000													34	21					0	0	1	0	0
RAD18	56852	broad.mit.edu	37	3	8940727	8940727	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:8940727C>T	ENST00000264926.2	-	11	1289	c.1173G>A	c.(1171-1173)caG>caA	p.Q391Q		NM_020165.3	NP_064550.3	Q9NS91	RAD18_HUMAN	RAD18 homolog (S. cerevisiae)	391					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(3)	15				OV - Ovarian serous cystadenocarcinoma(96;0.0552)		TATTATCTTCCTGTCCTAGGA	0.373000								Rad6 pathway					8	6					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611175	179611175	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179611175C>T	ENST00000360870.5	-	46	16174	c.15952G>A	c.(15952-15954)Gaa>Aaa	p.E5318K	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000589042.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8830							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACGTCTTTTTCACTTAATTCA	0.383000													12	19					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130222754	130222754	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:130222754C>T	ENST00000276211.5	+	12	1984	c.1639C>T	c.(1639-1641)Cct>Tct	p.P547S	ARHGAP36_ENST00000370921.1_Missense_Mutation_p.P411S|ARHGAP36_ENST00000370922.1_Missense_Mutation_p.P535S	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	547					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						CTACTTCTTTCCTTAGATGTT	0.527000													18	27					0	0	1	0	0
CITED1	4435	broad.mit.edu	37	X	71522095	71522095	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:71522095C>T	ENST00000246139.5	-	3	636		c.e3-1		CITED1_ENST00000373619.3_Splice_Site|CITED1_ENST00000445983.1_Splice_Site|CITED1_ENST00000431381.1_Splice_Site	NM_004143.3	NP_004134.2	Q99966	CITE1_HUMAN	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1						apoptosis|branching involved in ureteric bud morphogenesis|cell proliferation|melanin biosynthetic process|melanocyte differentiation|mesenchymal to epithelial transition|metanephros development|negative regulation of neuron apoptosis|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|nucleocytoplasmic transport|placenta development|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to cAMP|response to estrogen stimulus|response to insulin stimulus|response to interferon-gamma|response to interleukin-1|response to interleukin-11|response to interleukin-2|response to interleukin-4|response to interleukin-6|response to interleukin-9|response to lipopolysaccharide|response to parathyroid hormone stimulus|response to transforming growth factor beta stimulus|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	cytosol|nucleus	chromatin binding|co-SMAD binding|LBD domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			skin(1)	1	Renal(35;0.156)					GGTTGGCATCCTAGAAGACAG	0.507000													6	11					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768340	31768340	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:31768340C>T	ENST00000240587.4	-	2	2686	c.2359G>A	c.(2359-2361)Gac>Aac	p.D787N		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	787					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					ATGGGCTGGTCGTTGTTGACG	0.597000													26	31					0	0	1	0	0
TPSAB1	7177	broad.mit.edu	37	16	1291208	1291208	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:1291208G>A	ENST00000461509.2	+	2	331	c.137G>A	c.(136-138)aGg>aAg	p.R46K	TPSAB1_ENST00000338844.3_Missense_Mutation_p.R39K			P20231	TRYB2_HUMAN	tryptase alpha/beta 1	39	Peptidase S1.				proteolysis	extracellular region	protein binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|skin(1)	10		Hepatocellular(780;0.00369)				GAGGCCCCCAGGAGCAAGTGG	0.701000													18	53					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155212010	155212010	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:155212010C>T	ENST00000460012.1	-	17	2369	c.2012G>A	c.(2011-2013)cGa>cAa	p.R671Q	PLCH1_ENST00000494598.1_Missense_Mutation_p.R689Q|PLCH1_ENST00000447496.2_Missense_Mutation_p.R689Q|PLCH1_ENST00000334686.6_Missense_Mutation_p.R671Q|PLCH1_ENST00000414191.1_Missense_Mutation_p.R671Q|PLCH1_ENST00000340059.7_Missense_Mutation_p.R689Q			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	689	PI-PLC Y-box.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CTGCATCATTCGTCCTTCAGA	0.418000													9	16					0	0	1	0	0
ANKRD36BP1	84832	broad.mit.edu	37	1	168215769	168215769	+	RNA	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:168215769C>T	ENST00000358576.4	-	0	812					NR_026844.1															lung(1)	1						GGCACCTGGACTTACTCTCAG	0.393000													6	6					0	0	1	0	0
REG1B	5968	broad.mit.edu	37	2	79313546	79313546	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:79313546C>T	ENST00000305089.3	-	4	348	c.268G>A	c.(268-270)Gag>Aag	p.E90K		NM_006507.3	NP_006498.1	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta	90	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(40)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	51						GTGCTACTCTCCTTAATCAGT	0.488000													25	11					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72937999	72937999	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:72937999C>T	ENST00000328801.4	+	3	494	c.494C>T	c.(493-495)tCc>tTc	p.S165F		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	165						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					CGGCCAGGTTCCCTAGTGCTC	0.647000													6	15					0	0	1	0	0
KRT9	3857	broad.mit.edu	37	17	39723557	39723557	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:39723557C>T	ENST00000246662.4	-	7	1905	c.1840G>A	c.(1840-1842)Gga>Aga	p.G614R	KRT9_ENST00000588431.1_Missense_Mutation_p.G381R	NM_000226.3	NP_000217.2	P35527	K1C9_HUMAN	keratin 9	614	Tail.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Breast(137;0.000307)				cttcctcctccgtagccgcca	0.532000													11	25					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92543137	92543137	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:92543137G>A	ENST00000298047.6	+	12	9393	c.9376G>A	c.(9376-9378)Gat>Aat	p.D3126N	FAT3_ENST00000525166.1_Missense_Mutation_p.D2976N|FAT3_ENST00000409404.2_Missense_Mutation_p.D3126N			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3126	Cadherin 28.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGATGTGAATGATAACCCCCC	0.562000										TCGA Ovarian(4;0.039)			13	13					0	0	1	0	0
EFEMP1	2202	broad.mit.edu	37	2	56098217	56098217	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:56098217C>T	ENST00000394555.2	-	9	1477	c.1042G>A	c.(1042-1044)Gaa>Aaa	p.E348K	EFEMP1_ENST00000394554.1_Missense_Mutation_p.E348K|EFEMP1_ENST00000355426.3_Missense_Mutation_p.E348K|EFEMP1_ENST00000424836.2_Missense_Mutation_p.E210K	NM_001039348.2|NM_001039349.2	NP_001034437.1|NP_001034438.1	Q12805	FBLN3_HUMAN	EGF containing fibulin-like extracellular matrix protein 1	348	EGF-like 6; calcium-binding (Potential).|Mediates interaction with TIMP3.				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			NS(1)|breast(2)|endometrium(4)|large_intestine(6)|lung(5)|ovary(5)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CAACACATTTCATCCTCCCGG	0.373000													9	28					0	0	1	0	0
TCF4	6925	broad.mit.edu	37	18	52946789	52946789	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:52946789G>A	ENST00000354452.3	-	9	1259	c.648C>T	c.(646-648)ttC>ttT	p.F216F	TCF4_ENST00000398339.1_Silent_p.F318F|TCF4_ENST00000564999.1_Silent_p.F216F|TCF4_ENST00000570177.2_Silent_p.F86F|TCF4_ENST00000568740.1_Silent_p.F191F|TCF4_ENST00000566279.1_Silent_p.F156F|TCF4_ENST00000356073.4_Silent_p.F216F|TCF4_ENST00000537578.1_Silent_p.F192F|TCF4_ENST00000568673.1_Silent_p.F192F|TCF4_ENST00000561831.3_Silent_p.F56F|TCF4_ENST00000563760.1_5'UTR|TCF4_ENST00000544241.2_Silent_p.F145F|TCF4_ENST00000457482.3_Silent_p.F56F|TCF4_ENST00000570287.2_Silent_p.F56F|TCF4_ENST00000564403.2_Silent_p.F222F|TCF4_ENST00000564228.1_Silent_p.F145F|TCF4_ENST00000565018.2_Silent_p.F216F|TCF4_ENST00000567880.1_Silent_p.F156F|TCF4_ENST00000566286.1_Silent_p.F214F|TCF4_ENST00000537856.3_Silent_p.F86F|TCF4_ENST00000561992.1_Silent_p.F86F|TCF4_ENST00000543082.1_Silent_p.F174F|TCF4_ENST00000540999.1_Silent_p.F192F	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	216					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		TACCTTGCATGAAGAAGGAGC	0.498000													12	9					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248344203	248344203	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:248344203G>A	ENST00000359682.2	+	1	916	c.916G>A	c.(916-918)Gga>Aga	p.G306R		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GAAGATCTTAGGAAAGGGCAA	0.403000													67	123					0	0	1	0	0
NFIX	4784	broad.mit.edu	37	19	13192546	13192546	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:13192546C>T	ENST00000358552.3	+	6	1005	c.1005C>T	c.(1003-1005)atC>atT	p.I335I	NFIX_ENST00000587260.1_Silent_p.I376I|NFIX_ENST00000397661.2_Silent_p.I377I|NFIX_ENST00000588228.1_Silent_p.I330I|NFIX_ENST00000587760.1_Silent_p.I369I|NFIX_ENST00000592199.1_Silent_p.I377I|NFIX_ENST00000585575.1_Silent_p.I369I|NFIX_ENST00000360105.4_Silent_p.I339I			Q14938	NFIX_HUMAN	nuclear factor I/X (CCAAT-binding transcription factor)	377					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)			CGTCCATCATCCAGCAGTCGA	0.622000													17	41					0	0	1	0	0
TRIM46	80128	broad.mit.edu	37	1	155156498	155156498	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:155156498C>T	ENST00000368382.1	+	10	2180	c.2043C>T	c.(2041-2043)ttC>ttT	p.F681F	TRIM46_ENST00000334634.4_Silent_p.F704F|TRIM46_ENST00000392451.2_3'UTR|TRIM46_ENST00000468878.1_3'UTR|TRIM46_ENST00000545012.1_Silent_p.F578F	NM_001256599.1|NM_001256600.1|NM_001256601.1|NM_025058.4	NP_001243528.1|NP_001243529.1|NP_001243530.1|NP_079334.3	Q7Z4K8	TRI46_HUMAN	tripartite motif containing 46	704	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	29	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GGGTTTCCTTCCTGGATGCTG	0.667000													26	37					0	0	1	0	0
FIGF	2277	broad.mit.edu	37	X	15376147	15376147	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:15376147C>T	ENST00000297904.3	-	3	899	c.470G>A	c.(469-471)aGc>aAc	p.S157N		NM_004469.4	NP_004460.1	O43915	VEGFD_HUMAN	c-fos induced growth factor (vascular endothelial growth factor D)	157					angiogenesis|cell differentiation|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of mast cell chemotaxis|vascular endothelial growth factor receptor signaling pathway	extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|platelet-derived growth factor receptor binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	17	Hepatocellular(33;0.183)					GTACGAGGTGCTGGTGTTCAT	0.473000													43	70					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900743	151900743	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:151900743C>T	ENST00000393900.3	-	3	411	c.58G>A	c.(58-60)Gga>Aga	p.G20R	MAGEA12_ENST00000393869.3_Missense_Mutation_p.G20R|CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000357916.4_Missense_Mutation_p.G20R	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	20										breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGCCTCTCCTTGGGCCTCA	0.622000													35	43					0	0	1	0	0
MS4A14	84689	broad.mit.edu	37	11	60164169	60164169	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:60164169G>A	ENST00000300187.6	+	1	395	c.118G>A	c.(118-120)Gga>Aga	p.G40R	MS4A14_ENST00000531787.1_Intron|MS4A14_ENST00000531783.1_Missense_Mutation_p.G40R|MS4A14_ENST00000395005.2_Missense_Mutation_p.G40R|MS4A14_ENST00000395001.1_5'UTR	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	40						integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						TTTTCTGAAGGGAGAGCCAAG	0.443000													4	12					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139906958	139906958	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr9:139906958G>A	ENST00000265662.5	-	32	5313	c.5166C>T	c.(5164-5166)atC>atT	p.I1722I	ABCA2_ENST00000341511.6_Silent_p.I1722I|ABCA2_ENST00000371605.3_Silent_p.I1721I			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1721					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TGCGCACCGCGATCTTCCGCA	0.682000													30	6					0	0	1	0	0
MBD3	53615	broad.mit.edu	37	19	1581196	1581196	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:1581196G>A	ENST00000590550.2	-	4	777	c.404C>T	c.(403-405)cCc>cTc	p.P135L	MBD3_ENST00000156825.1_Missense_Mutation_p.P191L|MBD3_ENST00000585967.1_5'UTR|MBD3_ENST00000434436.3_Missense_Mutation_p.P191L|MBD3_ENST00000592012.1_Missense_Mutation_p.P159L			O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	191					transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCCGTGATGGGCATGGTGCT	0.652000													14	17					0	0	1	0	0
PRKCI	5584	broad.mit.edu	37	3	169940535	169940535	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:169940535C>T	ENST00000295797.4	+	1	383	c.78C>T	c.(76-78)gtC>gtT	p.V26V		NM_002740.5	NP_002731.4	P41743	KPCI_HUMAN	protein kinase C, iota	26	OPR.|Regulatory domain.|Required for interaction with RAB2.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	36	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			CCCACCAGGTCCGGGTGAAAG	0.706000													6	11					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75684294	75684294	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:75684294G>A	ENST00000370855.5	-	17	1523	c.1410C>T	c.(1408-1410)ttC>ttT	p.F470F	SLC44A5_ENST00000370859.3_Silent_p.F470F|SLC44A5_ENST00000535611.1_Silent_p.F340F	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	470						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						ATGCAATGACGAAGTTTATAA	0.418000													26	74					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143088564	143088564	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:143088564C>T	ENST00000275815.3	-	18	3003	c.2917G>A	c.(2917-2919)Gga>Aga	p.G973R		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	973	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				TCCTTGAATCCCTGAATACTG	0.612000													21	23					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44681692	44681692	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr20:44681692G>A	ENST00000454036.1	+	19	2619	c.2543G>A	c.(2542-2544)aGc>aAc	p.S848N	SLC12A5_ENST00000243964.3_Missense_Mutation_p.S825N	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	848					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCTGAGGGCAGCATCGACGTT	0.577000													36	19					0	0	1	0	0
TMPPE	643853	broad.mit.edu	37	3	33135663	33135663	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:33135663G>A	ENST00000342462.4	-	2	215	c.25C>T	c.(25-27)Cta>Tta	p.L9L	GLB1_ENST00000399402.3_Intron|TMPPE_ENST00000416695.2_Intron|GLB1_ENST00000307363.5_Intron|GLB1_ENST00000445488.2_Intron|GLB1_ENST00000307377.8_Intron	NM_001039770.2	NP_001034859.2	Q6ZT21	TMPPE_HUMAN	transmembrane protein with metallophosphoesterase domain	9						integral to membrane	metal ion binding			breast(1)|large_intestine(5)|lung(6)|prostate(1)	13						TTCGCGCCTAGGGACAGCTGC	0.582000													26	17					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187524478	187524478	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:187524478G>A	ENST00000441802.2	-	19	11411	c.11202C>T	c.(11200-11202)ttC>ttT	p.F3734F		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3734					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding	p.F3734L(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AGAGTTTCTGGAATACATTCA	0.463000										HNSCC(5;0.00058)			10	14					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56824744	56824744	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:56824744C>T	ENST00000229201.4	-	9	981	c.827G>A	c.(826-828)cGa>cAa	p.R276Q	TIMELESS_ENST00000553532.1_Missense_Mutation_p.R277Q|TIMELESS_ENST00000554616.1_Missense_Mutation_p.R277Q	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	277					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						GCCCCCAAATCGAGAATGCCT	0.438000													46	68					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48245080	48245080	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:48245080A>T	ENST00000394747.1	-	10	1736	c.1387T>A	c.(1387-1389)Tat>Aat	p.Y463N	ABCC11_ENST00000537808.1_Missense_Mutation_p.Y463N|ABCC11_ENST00000394748.1_Missense_Mutation_p.Y463N|ABCC11_ENST00000356608.2_Missense_Mutation_p.Y463N|ABCC11_ENST00000353782.5_Missense_Mutation_p.Y463N	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	463						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GTCTGGACATAGAAAACAGGG	0.483000													51	64					0	0	1	0	0
OR5B21	219968	broad.mit.edu	37	11	58275110	58275110	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:58275110G>A	ENST00000360374.2	-	1	468	c.469C>T	c.(469-471)Cat>Tat	p.H157Y		NM_001005218.1	NP_001005218.1	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B, member 21	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CCTGCTGCATGGATAGAGGCA	0.502000													8	8					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86888817	86888817	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:86888817G>T	ENST00000373119.4	+	8	1763	c.1618G>T	c.(1618-1620)Gta>Tta	p.V540L	KLHL4_ENST00000373114.4_Missense_Mutation_p.V540L	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	540						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						TCTAAATACTGTAGAAAGATG	0.418000													3	40					0.004672	0.00468064	1	1	0
ACOXL	55289	broad.mit.edu	37	2	111789271	111789271	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:111789271C>T	ENST00000389811.4	+	16	1663	c.1439C>T	c.(1438-1440)tCc>tTc	p.S480F	ACOXL_ENST00000439055.1_Missense_Mutation_p.S450F			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	480					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						GCTTCTCTGTCCCTGGCACAC	0.502000													22	25					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31313488	31313488	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:31313488G>A	ENST00000265071.2	+	8	1582	c.1317G>A	c.(1315-1317)tcG>tcA	p.S439S	CDH6_ENST00000514738.1_Silent_p.S384S	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	439	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GAAATGGTTCGATTTTTACAT	0.393000													35	53					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179584982	179584982	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179584982C>T	ENST00000589042.1	-	81	23611	c.23387G>A	c.(23386-23388)cGa>cAa	p.R7796Q	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.R7479Q|TTN_ENST00000342992.6_Missense_Mutation_p.R6552Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7479	Ig-like 60.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCACGAATCGTGGAGGTTC	0.453000													13	18					0	0	1	0	0
PDK3	5165	broad.mit.edu	37	X	24517001	24517001	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:24517001C>T	ENST00000441463.2	+	3	304	c.304C>T	c.(304-306)Cca>Tca	p.P102S	PDK3_ENST00000493226.1_3'UTR|PDK3_ENST00000379162.4_Missense_Mutation_p.P102S	NM_001142386.2	NP_001135858.1	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase, isozyme 3	102					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			NS(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						CCCTGAGGATCCACAGGTCTT	0.303000													13	11					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20544117	20544117	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:20544117G>A	ENST00000504154.1	+	21	2396	c.2143_splice	c.e21-1	p.G715_splice	SLIT2_ENST00000503837.1_Splice_Site_p.G711_splice|SLIT2_ENST00000509394.2_3'UTR|SLIT2_ENST00000273739.5_Splice_Site_p.G719_splice|SLIT2_ENST00000503823.1_Splice_Site_p.G707_splice	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	715					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TGCGATTTAGGAAATGATGAC	0.408000													83	96					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122631770	122631770	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:122631770T>C	ENST00000195173.4	-	18	2945	c.2642A>G	c.(2641-2643)aAc>aGc	p.N881S	SEMA5B_ENST00000451055.2_Missense_Mutation_p.N936S|SEMA5B_ENST00000357599.3_Missense_Mutation_p.N882S			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	882	TSP type-1 3.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GGGCTCCGGGTTAGTGCACGT	0.711000													7	46					0	0	1	0	0
MAGEB16	139604	broad.mit.edu	37	X	35821177	35821177	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:35821177G>A	ENST00000399989.1	+	2	1143	c.864G>A	c.(862-864)atG>atA	p.M288I	MAGEB16_ENST00000399985.1_Missense_Mutation_p.M288I|MAGEB16_ENST00000399988.1_Missense_Mutation_p.M288I|MAGEB16_ENST00000399992.1_Missense_Mutation_p.M320I|MAGEB16_ENST00000399987.1_Missense_Mutation_p.M288I	NM_001099921.1	NP_001093391.1	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	288	MAGE.							p.M455I(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						CCAGCAAGATGAAAGTCCTGG	0.498000													8	26					0	0	1	0	0
PRPH2	5961	broad.mit.edu	37	6	42689706	42689706	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:42689706G>A	ENST00000230381.5	-	1	606	c.367C>T	c.(367-369)Cgg>Tgg	p.R123W		NM_000322.4	NP_000313.2	P23942	PRPH2_HUMAN	peripherin 2 (retinal degeneration, slow)	123					cell adhesion|visual perception	integral to membrane		p.R123W(1)		NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	18	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			AGCGAGCCCCGAAGCAGAAAG	0.547000													15	10					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158908248	158908248	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:158908248G>A	ENST00000368140.1	+	3	572	c.327G>A	c.(325-327)caG>caA	p.Q109Q	PYHIN1_ENST00000392252.3_Silent_p.Q100Q|PYHIN1_ENST00000392254.2_Silent_p.Q109Q|PYHIN1_ENST00000368138.3_Silent_p.Q100Q|PYHIN1_ENST00000368135.4_Silent_p.Q109Q	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	109					cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					AGACGAAACAGAAAGAAGTGT	0.428000													23	36					0	0	1	0	0
MAP2K7	5609	broad.mit.edu	37	19	7977033	7977033	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:7977033G>A	ENST00000545011.1	+	10	1270		c.e10-1		MAP2K7_ENST00000397979.3_Splice_Site|MAP2K7_ENST00000397983.3_Splice_Site|MAP2K7_ENST00000397981.3_Splice_Site			O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7						activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|central_nervous_system(3)|endometrium(1)|large_intestine(8)|lung(4)|ovary(1)	19					Etoposide(DB00773)	TCTTGCTCTAGCCTTACTAAA	0.602000													22	39					0	0	1	0	0
NKD2	85409	broad.mit.edu	37	5	1033491	1033491	+	Silent	SNP	A	A	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:1033491A>C	ENST00000296849.5	+	5	436	c.207A>C	c.(205-207)gcA>gcC	p.A69A	NKD2_ENST00000274150.4_Silent_p.A69A|NKD2_ENST00000537972.1_Silent_p.A69A	NM_033120.2	NP_149111.1	Q969F2	NKD2_HUMAN	naked cuticle homolog 2 (Drosophila)	69	Targeting to the basolateral cell membrane.				exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(3)|large_intestine(1)|lung(8)|pancreas(1)	14	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			CCCTAGTGGCACTCCCCGCTG	0.682000													3	9					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152732825	152732825	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:152732825G>A	ENST00000368773.1	+	2	819	c.761G>A	c.(760-762)aGa>aAa	p.R254K	KPRP_ENST00000606109.1_Missense_Mutation_p.R254K	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	254						cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCACCAGCAGATGCCTTCCT	0.612000													31	28					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834450	101834450	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:101834450C>T	ENST00000506729.1	-	1	270	c.99G>A	c.(97-99)agG>agA	p.R33R	SLCO6A1_ENST00000379810.1_Silent_p.R33R|SLCO6A1_ENST00000379807.3_Silent_p.R33R|SLCO6A1_ENST00000513675.1_Silent_p.R33R|SLCO6A1_ENST00000389019.3_Silent_p.R33R			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	33						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CCTTGGCCCTCCTGTCCTTAG	0.607000													112	154					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70961825	70961825	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:70961825G>A	ENST00000357250.6	-	28	2028	c.1870C>T	c.(1870-1872)Cct>Tct	p.P624S	COL9A1_ENST00000320755.7_Missense_Mutation_p.P381S|COL9A1_ENST00000370499.4_Missense_Mutation_p.P381S|COL9A1_ENST00000489611.1_5'UTR	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	624	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						ATACTCACAGGAAGCCCCTGG	0.483000													24	32					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26299688	26299688	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:26299688G>A	ENST00000335473.7	+	31	5288	c.5038G>A	c.(5038-5040)Gaa>Aaa	p.E1680K	MYO18B_ENST00000407587.2_Missense_Mutation_p.E1681K|MYO18B_ENST00000536101.1_Missense_Mutation_p.E1680K|MYO18B_ENST00000536204.1_3'UTR	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1680	Gln-rich.|Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CTCTCTGGGGGAAAATTGCGT	0.542000													6	11					0	0	1	0	0
FUNDC2	65991	broad.mit.edu	37	X	154282877	154282877	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:154282877C>T	ENST00000369498.3	+	5	754	c.500C>T	c.(499-501)tCa>tTa	p.S167L	FUNDC2_ENST00000484175.1_3'UTR	NM_023934.3	NP_076423.2	Q9BWH2	FUND2_HUMAN	FUN14 domain containing 2	167						mitochondrion				breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	13	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CAGGTGGTGTCATTTGTGAAG	0.383000													59	73					0	0	1	0	0
ZNF793	390927	broad.mit.edu	37	19	38028070	38028070	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:38028070G>A	ENST00000445217.1	+	4	545	c.510G>A	c.(508-510)ggG>ggA	p.G170G	ZNF793_ENST00000542455.1_Silent_p.G170G|ZNF793_ENST00000587143.1_Silent_p.G170G|ZNF793_ENST00000589319.1_Intron|ZNF793_ENST00000588578.1_3'UTR			Q6ZN11	ZN793_HUMAN	zinc finger protein 793	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|lung(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATGCTTATGGGAAATTGCTTC	0.418000													8	7					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11732333	11732333	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:11732333G>A	ENST00000304623.8	-	2	278	c.89C>T	c.(88-90)tCc>tTc	p.S30F	CTNND2_ENST00000458100.2_5'UTR|CTNND2_ENST00000359640.2_Missense_Mutation_p.S30F	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	30					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GGGGCTCAGGGAACTCGTCTT	0.507000													28	30					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	86068206	86068206	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:86068206G>A	ENST00000373131.1	+	8	1587	c.1424G>A	c.(1423-1425)cGa>cAa	p.R475Q	DACH2_ENST00000373125.4_Missense_Mutation_p.R488Q|DACH2_ENST00000510272.1_Missense_Mutation_p.R269Q|DACH2_ENST00000477378.2_3'UTR|DACH2_ENST00000508860.1_Missense_Mutation_p.R321Q	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	488	DACHbox-C.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						AAGGAGCTGCGACTGGAGCTC	0.413000													8	7					0	0	1	0	0
TRIT1	54802	broad.mit.edu	37	1	40312904	40312904	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:40312904G>T	ENST00000316891.5	-	8	1008	c.994C>A	c.(994-996)Cgt>Agt	p.R332S	TRIT1_ENST00000372818.1_Intron|TRIT1_ENST00000537440.1_Missense_Mutation_p.R28S|TRIT1_ENST00000441669.2_Missense_Mutation_p.R250S|TRIT1_ENST00000541099.1_Intron|TRIT1_ENST00000491865.1_5'UTR|TRIT1_ENST00000545233.1_Missense_Mutation_p.R86S|TRIT1_ENST00000537223.1_Missense_Mutation_p.R28S	NM_017646.4	NP_060116.2	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1	332					tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			breast(1)|large_intestine(5)|liver(1)|lung(3)|ovary(2)|pancreas(1)|stomach(1)|urinary_tract(1)	15	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CTCAAAAAACGGTTTTTAACC	0.353000													22	20					3.6726e-16	3.73462e-16	1	1	0
ITGAX	3687	broad.mit.edu	37	16	31374520	31374520	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:31374520G>A	ENST00000268296.4	+	14	1656	c.1535G>A	c.(1534-1536)gGg>gAg	p.G512E	ITGAX_ENST00000562522.1_Missense_Mutation_p.G512E	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	512					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						GTTCTCTACGGGGAGCAGGGC	0.637000													56	79					0	0	1	0	0
TDRD10	126668	broad.mit.edu	37	1	154516518	154516518	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:154516518G>A	ENST00000368482.4	+	9	1421	c.583G>A	c.(583-585)Gag>Aag	p.E195K	TDRD10_ENST00000368480.3_Missense_Mutation_p.E195K|TDRD10_ENST00000479937.1_3'UTR	NM_001098475.1|NM_182499.3	NP_001091945.1|NP_872305.3	Q5VZ19	TDR10_HUMAN	tudor domain containing 10	195							nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CGTCCGTGGGGAGGCGGGGCT	0.622000													18	101					0	0	1	0	0
FPGT-TNNI3K	100526835	broad.mit.edu	37	1	74701796	74701796	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:74701796G>A	ENST00000370895.1	+	4	389	c.354G>A	c.(352-354)aaG>aaA	p.K118K	TNNI3K_ENST00000370891.2_Silent_p.K118K|FPGT-TNNI3K_ENST00000370899.3_Silent_p.K118K|FPGT-TNNI3K_ENST00000557284.1_Silent_p.K118K|TNNI3K_ENST00000370893.1_Silent_p.K118K|TNNI3K_ENST00000326637.3_Silent_p.K17K			Q59H18	TNI3K_HUMAN		17						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										ATGAATGGAAGAAAAAAGTCA	0.308000													9	16					0	0	1	0	0
TSNARE1	203062	broad.mit.edu	37	8	143436032	143436032	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:143436032G>A	ENST00000519651.1	-	2	157	c.54C>T	c.(52-54)ttC>ttT	p.F18F	TSNARE1_ENST00000524325.1_Silent_p.F18F|TSNARE1_ENST00000307180.3_Silent_p.F18F|TSNARE1_ENST00000520166.1_Silent_p.F18F			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	18			F -> L (in dbSNP:rs7814359).		vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					AAGGTCCCCCGAAAGGGCCAC	0.612000													4	49					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587343	55587343	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:55587343C>T	ENST00000333976.4	+	1	258	c.238C>T	c.(238-240)Ccc>Tcc	p.P80S		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	80					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				CATCATTGCTCCCAAGATGTT	0.408000													38	42					0	0	1	0	0
TRGV3	6976	broad.mit.edu	37	7	38398350	38398350	+	RNA	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:38398350G>A	ENST00000390346.2	-	0	299																											GATCGCAAGTGATTTCAGCAG	0.488000													21	73					0	0	1	0	0
C1QA	712	broad.mit.edu	37	1	22965712	22965712	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:22965712C>T	ENST00000374642.3	+	3	754	c.550C>T	c.(550-552)Cga>Tga	p.R184*	C1QA_ENST00000402322.1_Nonsense_Mutation_p.R184*	NM_015991.2	NP_057075.1	P02745	C1QA_HUMAN	complement component 1, q subcomponent, A chain	184	C1q.				cell-cell signaling|complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				autonomic_ganglia(1)|liver(1)|lung(3)|skin(1)	6		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.41e-27)|Colorectal(126;1.52e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.63e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000541)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GGGCCAGGTCCGACGCTCCCT	0.602000													14	61					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26351197	26351197	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:26351197C>T	ENST00000335473.7	+	39	6273	c.6023C>T	c.(6022-6024)tCa>tTa	p.S2008L	MYO18B_ENST00000407587.2_Missense_Mutation_p.S2009L|MYO18B_ENST00000536101.1_Missense_Mutation_p.S2008L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2008	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GAGGAGCTTTCACAGGCGGCC	0.652000													11	14					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238048097	238048097	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:238048097G>A	ENST00000366570.4	-	10	1520	c.1362C>T	c.(1360-1362)tcC>tcT	p.S454S	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	454	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCACCACACAGGATGGTGTCT	0.488000													6	7					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125557560	125557560	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:125557560T>C	ENST00000241305.3	-	6	975	c.821A>G	c.(820-822)aAc>aGc	p.N274S	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	274	F5/8 type C.				cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GGACTGAGGGTTTATGCGGAT	0.527000													21	2					0	0	1	0	0
PHIP	55023	broad.mit.edu	37	6	79664553	79664553	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:79664553G>A	ENST00000275034.4	-	35	4198	c.4031C>T	c.(4030-4032)cCg>cTg	p.P1344L	PHIP_ENST00000479165.1_5'UTR	NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1344	Bromo 2.				insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding	p.P1344L(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		GAGATCTACCGGCTGACGGAA	0.348000													6	9					0	0	1	0	0
ACTL6B	51412	broad.mit.edu	37	7	100244709	100244709	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:100244709C>T	ENST00000160382.5	-	10	928		c.e10-1			NM_016188.4	NP_057272.1	O94805	ACL6B_HUMAN	actin-like 6B						chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|skin(1)	13	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TGCAGCCACCCTACCCAGAAG	0.617000													20	38					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175328826	175328826	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:175328826G>A	ENST00000367674.1	-	15	3604	c.2896C>T	c.(2896-2898)Cca>Tca	p.P966S	TNR_ENST00000263525.2_Missense_Mutation_p.P966S	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	966	Fibronectin type-III 8.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GCTTCTGTTGGAGTGATATTG	0.498000													18	32					0	0	1	0	0
PHKG2	5261	broad.mit.edu	37	16	30762446	30762446	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:30762446C>T	ENST00000563588.1	+	3	354	c.115C>T	c.(115-117)Cgc>Tgc	p.R39C	RP11-2C24.4_ENST00000483578.1_lincRNA|PHKG2_ENST00000424889.3_Missense_Mutation_p.R39C|PHKG2_ENST00000328273.7_Missense_Mutation_p.R39C	NM_000294.2	NP_000285.1	P15735	PHKG2_HUMAN	phosphorylase kinase, gamma 2 (testis)	39	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			ovary(1)|skin(1)	2			Colorectal(24;0.198)			CTCTGTGGTCCGCCGTTGTGT	0.582000													23	23					0	0	1	0	0
PALM	5064	broad.mit.edu	37	19	746418	746418	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:746418C>T	ENST00000264560.7	+	8	830	c.636C>T	c.(634-636)acC>acT	p.T212T	PALM_ENST00000606643.1_3'UTR|PALM_ENST00000338448.5_Silent_p.T256T	NM_001040134.1	NP_001035224.1	O75781	PALM_HUMAN	paralemmin	256					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane				endometrium(2)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		CGGCAGAGACCCGGGGGGCTG	0.736000													9	10					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141755813	141755813	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:141755813C>T	ENST00000475668.2	+	29	3551	c.3497C>T	c.(3496-3498)tCc>tTc	p.S1166F	MGAM_ENST00000549489.2_Missense_Mutation_p.S1166F			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1166	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity	p.S1166F(2)		cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AAGAAGAATTCCTATGGTGTC	0.498000													6	13					0	0	1	0	0
MAP7D3	79649	broad.mit.edu	37	X	135323391	135323391	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:135323391G>A	ENST00000316077.9	-	5	683	c.463C>T	c.(463-465)Ctt>Ttt	p.L155F	MAP7D3_ENST00000370661.1_Missense_Mutation_p.L155F|MAP7D3_ENST00000370663.5_Missense_Mutation_p.L137F	NM_024597.3	NP_078873.2	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	155						cytoplasm|spindle				central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(1)	44	Acute lymphoblastic leukemia(192;0.000127)					TCATCAGCAAGTCTCCTCCGT	0.323000													22	36					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16883983	16883983	+	Silent	SNP	C	C	T	rs148295009		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:16883983C>T	ENST00000524140.2	+	11	2875	c.2457C>T	c.(2455-2457)ttC>ttT	p.F819F	NWD1_ENST00000549814.1_Silent_p.F819F|NWD1_ENST00000339803.6_Silent_p.F684F|NWD1_ENST00000523826.1_Silent_p.F613F|NWD1_ENST00000379808.3_Silent_p.F819F|NWD1_ENST00000552788.1_Silent_p.F819F	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	819							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TCCATTTCTTCGCCACCTCAC	0.582000													29	29					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	71004162	71004162	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:71004162T>C	ENST00000357250.6	-	5	562	c.404A>G	c.(403-405)gAt>gGt	p.D135G	COL9A1_ENST00000370496.3_Missense_Mutation_p.D135G	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	135	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						CCCAGAGGAATCCTGAATCTG	0.438000													34	43					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564267	176564267	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:176564267G>A	ENST00000367662.3	+	3	2691	c.1527G>A	c.(1525-1527)ttG>ttA	p.L509L	PAPPA2_ENST00000367661.3_Silent_p.L509L	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	509	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						ATGTGGAATTGATCTCCCAGT	0.532000													5	40					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28828809	28828809	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:28828809C>T	ENST00000422425.2	+	41	3062	c.3018C>T	c.(3016-3018)acC>acT	p.T1006T	PLB1_ENST00000541605.1_Intron|PLB1_ENST00000327757.5_Silent_p.T1017T	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	1017	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					CCCTTTGGACCAATATGGTAA	0.527000													25	71					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19838948	19838948	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:19838948G>A	ENST00000507958.1	-	5	1138	c.148C>T	c.(148-150)Cgt>Tgt	p.R50C	CDH18_ENST00000502796.1_Missense_Mutation_p.R50C|CDH18_ENST00000382275.1_Missense_Mutation_p.R50C|CDH18_ENST00000274170.4_Missense_Mutation_p.R50C|CDH18_ENST00000511273.1_Missense_Mutation_p.R50C|CDH18_ENST00000506372.1_Missense_Mutation_p.R50C			Q13634	CAD18_HUMAN	cadherin 18, type 2	50					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R50C(2)		breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTTTTGGGACGATGATGGACT	0.418000													17	14					0	0	1	0	0
MTM1	4534	broad.mit.edu	37	X	149828911	149828911	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:149828911G>A	ENST00000370396.2	+	13	1475	c.1421G>A	c.(1420-1422)cGa>cAa	p.R474Q	MTM1_ENST00000413012.2_Missense_Mutation_p.R437Q|MTM1_ENST00000543350.1_Missense_Mutation_p.R359Q|MTM1_ENST00000542741.1_Missense_Mutation_p.R379Q|MTM1_ENST00000306167.7_3'UTR	NM_000252.2	NP_000243.1	Q13496	MTM1_HUMAN	myotubularin 1	474	Myotubularin phosphatase.				endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Acute lymphoblastic leukemia(192;6.56e-05)					TATAGTTGCCGATTTGGTACT	0.313000													13	19					0	0	1	0	0
GAB1	2549	broad.mit.edu	37	4	144381609	144381609	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:144381609C>A	ENST00000262995.4	+	9	2289	c.1862C>A	c.(1861-1863)cCc>cAc	p.P621H	GAB1_ENST00000505913.1_Missense_Mutation_p.P488H|GAB1_ENST00000262994.4_Missense_Mutation_p.P591H	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	591					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					AATTATGTTCCCATGAACCCA	0.448000													50	56					1.86277e-20	1.89778e-20	1	1	0
CCDC11	220136	broad.mit.edu	37	18	47769279	47769279	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:47769279G>A	ENST00000398545.4	-	6	1321	c.1204C>T	c.(1204-1206)Caa>Taa	p.Q402*		NM_145020.3	NP_659457.2	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	402										endometrium(1)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|pancreas(1)|skin(1)	20				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		CACTTTTCTTGAACTTGAAGT	0.363000													33	76					0	0	1	0	0
PROX2	283571	broad.mit.edu	37	14	75329636	75329636	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:75329636C>T	ENST00000556489.2	-	1	901	c.902G>A	c.(901-903)gGa>gAa	p.G301E	PROX2_ENST00000445876.1_Missense_Mutation_p.G301E|PROX2_ENST00000556084.2_Intron	NM_001243007.1	NP_001229936.1	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	301					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(3)	6			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		TGATAAATTTCCTACTGGGAC	0.557000													47	6					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75157198	75157198	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:75157198C>T	ENST00000342232.4	-	4	1511	c.1471G>A	c.(1471-1473)Ggg>Agg	p.G491R		NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	491					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			AGTCTCGCCCCTGAGCTGGGG	0.562000													78	55					0	0	1	0	0
IBSP	3381	broad.mit.edu	37	4	88732565	88732565	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:88732565G>A	ENST00000226284.5	+	7	524	c.457G>A	c.(457-459)Gaa>Aaa	p.E153K		NM_004967.3	NP_004958.2	P21815	SIAL_HUMAN	integrin-binding sialoprotein	153	Asp/Glu-rich (acidic).|Poly-Glu.				biomineral tissue development|cell adhesion|ossification					breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)	21		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		TGATgaagaagaagaggagga	0.413000													16	8					0	0	1	0	0
LMF1	64788	broad.mit.edu	37	16	921242	921242	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:921242G>A	ENST00000262301.11	-	7	1015	c.997C>T	c.(997-999)Ccc>Tcc	p.P333S	LMF1_ENST00000399843.2_Missense_Mutation_p.P333S|LMF1_ENST00000543238.1_Missense_Mutation_p.P96S|LMF1_ENST00000568897.1_Missense_Mutation_p.P116S|LMF1_ENST00000568268.1_5'UTR	NM_022773.2	NP_073610.2	Q96S06	LMF1_HUMAN	lipase maturation factor 1	333						endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	18		Hepatocellular(780;0.00308)				GGCCCAGAGGGGAACAAGAAT	0.642000													10	14					0	0	1	0	0
EDNRA	1909	broad.mit.edu	37	4	148407109	148407109	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:148407109C>T	ENST00000324300.5	+	2	791	c.276C>T	c.(274-276)atC>atT	p.I92I	EDNRA_ENST00000506066.1_Silent_p.I92I|EDNRA_ENST00000358556.4_Silent_p.I92I|EDNRA_ENST00000511804.1_Intron|EDNRA_ENST00000339690.5_Silent_p.I92I	NM_001957.3	NP_001948.1	P25101	EDNRA_HUMAN	endothelin receptor type A	92					activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)	17	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	CTATTTTCATCGTGGGAATGG	0.443000													35	69					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52555399	52555399	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:52555399C>T	ENST00000321725.6	+	56	6007	c.5931C>T	c.(5929-5931)agC>agT	p.S1977S		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1977	Laminin EGF-like 2.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCCCCAGCAGCCCTTGTAGTG	0.632000													32	31					0	0	1	0	0
KLK4	9622	broad.mit.edu	37	19	51411875	51411875	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:51411875C>T	ENST00000324041.1	-	3	434	c.435G>A	c.(433-435)ggG>ggA	p.G145G	KLK4_ENST00000431178.2_Silent_p.G96G	NM_004917.3	NP_004908.3	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4	145	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(8)	19		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		GGCAAGAGTTCCCCGCGGTAG	0.612000													15	34					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2163283	2163283	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:2163283G>A	ENST00000262304.4	-	12	3072	c.2864C>T	c.(2863-2865)cCc>cTc	p.P955L	RP11-304L19.4_ENST00000568795.1_RNA|PKD1_ENST00000423118.1_Missense_Mutation_p.P955L	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	955	PKD 4.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CTCCACCACGGGGCTGTACCT	0.612000													61	86					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70465074	70465074	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:70465074C>T	ENST00000503640.1	-	2	809	c.754G>A	c.(754-756)Gaa>Aaa	p.E252K	UGT2A1_ENST00000502343.1_5'UTR|UGT2A2_ENST00000457664.2_Missense_Mutation_p.E261K|UGT2A1_ENST00000286604.4_Missense_Mutation_p.E296K|UGT2A1_ENST00000512704.1_Missense_Mutation_p.E252K|UGT2A1_ENST00000514019.1_Missense_Mutation_p.E462K	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	252					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						AACCAAATTTCAGCTTTCCCC	0.393000													7	19					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656328	19656328	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:19656328G>A	ENST00000586018.1	+	8	3094	c.2992G>A	c.(2992-2994)Gag>Aag	p.E998K	CILP2_ENST00000291495.4_Missense_Mutation_p.E992K			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	992						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						AGCCTGCGTGGAGTTCAAGTG	0.701000													19	17					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54848879	54848879	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:54848879G>A	ENST00000291759.4	-	5	800	c.744C>T	c.(742-744)gtC>gtT	p.V248V		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	248	Ig-like C2-type 3.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		TGATGTAGCCGACATCAGAGC	0.657000													18	10					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80382693	80382693	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:80382693G>A	ENST00000265080.4	+	9	1378	c.1311G>A	c.(1309-1311)agG>agA	p.R437R	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	437					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		AAAACATAAGGAAAAACCTTG	0.473000													18	17					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73046784	73046784	+	RNA	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:73046784C>T	ENST00000604411.1	+	0	34745				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						CTCAGGCCTTCGGTCCAATTC	0.483000													38	34					0	0	1	0	0
PVRL2	5819	broad.mit.edu	37	19	45368754	45368754	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:45368754C>T	ENST00000252483.5	+	2	315	c.315C>T	c.(313-315)ttC>ttT	p.F105F	PVRL2_ENST00000252485.4_Silent_p.F105F	NM_001042724.1	NP_001036189.1	Q92692	PVRL2_HUMAN	poliovirus receptor-related 2 (herpesvirus entry mediator B)	105	Ig-like V-type.				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(6)|lung(5)	13	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		GGCTGTCCTTCGTCTCTGCCA	0.652000													5	8					0	0	1	0	0
AMHR2	269	broad.mit.edu	37	12	53819603	53819603	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:53819603G>A	ENST00000257863.4	+	6	832	c.752G>A	c.(751-753)gGc>gAc	p.G251D	AMHR2_ENST00000379791.3_Missense_Mutation_p.G251D|AMHR2_ENST00000550311.1_Missense_Mutation_p.G251D	NM_001164690.1|NM_020547.2	NP_001158162.1|NP_065434.1	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II	251	Protein kinase.				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|skin(2)	34					Adenosine triphosphate(DB00171)	GAACTTCCAGGCCTACAGCAC	0.602000													29	33					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140710992	140710992	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:140710992C>T	ENST00000517417.1	+	1	741	c.741C>T	c.(739-741)taC>taT	p.Y247Y	PCDHGA1_ENST00000378105.3_Silent_p.Y247Y	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCACAATACCATATAAATG	0.502000													21	4					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141762434	141762434	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:141762434G>A	ENST00000475668.2	+	35	4243	c.4189G>A	c.(4189-4191)Gaa>Aaa	p.E1397K	MGAM_ENST00000549489.2_Missense_Mutation_p.E1397K			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1397	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GTGGAAGAGGGAAATAGAAGA	0.408000													8	6					0	0	1	0	0
RTCB	51493	broad.mit.edu	37	22	32793981	32793981	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:32793981A>C	ENST00000216038.5	-	7	859	c.761T>G	c.(760-762)gTg>gGg	p.V254G	RTCB_ENST00000451746.2_Intron	NM_014306.4	NP_055121.1			RNA 2',3'-cyclic phosphate and 5'-OH ligase																		CATCACACACACCTGTCCCTT	0.458000													33	50					0	0	1	0	0
IGKV1D-42	28892	broad.mit.edu	37	2	90229425	90229425	+	RNA	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:90229425C>T	ENST00000390278.2	+	0	265																											GGGGTCTCATCGAGGTTCAGT	0.478000													43	27					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166166906	166166906	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:166166906C>T	ENST00000375437.2	+	7	1061	c.771C>T	c.(769-771)ttC>ttT	p.F257F	SCN2A_ENST00000283256.6_Silent_p.F257F|SCN2A_ENST00000375427.2_Silent_p.F257F|SCN2A_ENST00000357398.3_Silent_p.F257F	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	257					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TGACTGTGTTCTGTCTAAGCG	0.428000													69	65					0	0	1	0	0
AQP3	360	broad.mit.edu	37	9	33443839	33443839	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr9:33443839C>T	ENST00000297991.4	-	2	240	c.160G>A	c.(160-162)Ggt>Agt	p.G54S	AQP3_ENST00000493581.1_5'UTR	NM_004925.4	NP_004916.1	Q92482	AQP3_HUMAN	aquaporin 3 (Gill blood group)	54					excretion|odontogenesis|positive regulation of immune system process|regulation of keratinocyte differentiation|response to calcium ion|response to retinoic acid|response to vitamin D	basolateral plasma membrane|cell-cell junction|cytoplasm	glycerol channel activity|water channel activity			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.0899)		AGGAAACCACCGTGGGTGCCC	0.607000													10	2					0	0	1	0	0
CCR7	1236	broad.mit.edu	37	17	38711757	38711757	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:38711757C>T	ENST00000246657.2	-	3	436	c.374G>A	c.(373-375)gGt>gAt	p.G125D	CCR7_ENST00000579344.1_Missense_Mutation_p.G119D	NM_001838.3	NP_001829.1	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7	125					cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		Breast(137;0.000496)				AAAGTGGACACCGAAGACCCA	0.547000													12	24					0	0	1	0	0
NAT6	24142	broad.mit.edu	37	3	50334688	50334688	+	Silent	SNP	G	G	A	rs35565547		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:50334688G>A	ENST00000443842.1	-	2	1014	c.207C>T	c.(205-207)ccC>ccT	p.P69P	HYAL3_ENST00000513170.1_Intron|NAT6_ENST00000417393.1_Silent_p.P69P|HYAL3_ENST00000450982.1_Intron|NAT6_ENST00000443094.2_Silent_p.P69P|HYAL3_ENST00000415204.1_Intron|HYAL3_ENST00000359051.3_Intron|NAT6_ENST00000354862.4_Silent_p.P91P|HYAL3_ENST00000336307.1_Intron					N-acetyltransferase 6 (GCN5-related)											endometrium(3)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CCAGGAGCTCGGGTCGGCGGT	0.642000													33	16					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76465400	76465400	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:76465400C>T	ENST00000396423.2	+	5	707	c.583C>T	c.(583-585)Cct>Tct	p.P195S	HNF4G_ENST00000354370.1_Missense_Mutation_p.P158S	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	158					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TAAATATATTCCTGCCTTCTG	0.338000													24	34					0	0	1	0	0
TEAD4	7004	broad.mit.edu	37	12	3149415	3149415	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:3149415C>T	ENST00000359864.2	+	12	1371	c.1181C>T	c.(1180-1182)aCc>aTc	p.T394I	TEAD4_ENST00000397122.2_Missense_Mutation_p.T265I|TEAD4_ENST00000358409.2_Missense_Mutation_p.T351I	NM_003213.3	NP_003204.2	Q15561	TEAD4_HUMAN	TEA domain family member 4	394					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			GAGAACTTCACCATCCTGCAG	0.567000													22	36					0	0	1	0	0
RPGR	6103	broad.mit.edu	37	X	38128990	38128990	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:38128990G>A	ENST00000339363.3	-	18	3119	c.2952C>T	c.(2950-2952)atC>atT	p.I984I	TM4SF2_ENST00000465127.1_Intron|RPGR_ENST00000318842.7_Silent_p.I779I|RPGR_ENST00000338898.3_3'UTR|RPGR_ENST00000309513.3_Silent_p.I717I			Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator	984					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	25						TTTTTAAAATGATCTGGTCTC	0.368000													33	38					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124597028	124597028	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:124597028G>A	ENST00000368904.1	-	6	1440	c.491C>T	c.(490-492)tCc>tTc	p.S164F	CUZD1_ENST00000392790.1_Missense_Mutation_p.S164F|CUZD1_ENST00000545804.1_Missense_Mutation_p.S164F			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	164	CUB 2.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		GCTGGTGAAGGATCCTTCCAA	0.418000													22	4					0	0	1	0	0
CSNK1A1	1452	broad.mit.edu	37	5	148891409	148891409	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:148891409C>T	ENST00000261798.5	-	6	1055	c.623G>A	c.(622-624)gGa>gAa	p.G208E	CSNK1A1_ENST00000504676.1_Missense_Mutation_p.G119E|CSNK1A1_ENST00000377843.2_Missense_Mutation_p.G208E|CSNK1A1_ENST00000515435.1_Missense_Mutation_p.G147E|CSNK1A1_ENST00000606299.1_Intron|CSNK1A1_ENST00000606719.1_Missense_Mutation_p.G5E|CSNK1A1_ENST00000515768.1_Missense_Mutation_p.G236E	NM_001271741.1	NP_001258670.1	P48729	KC1A_HUMAN	casein kinase 1, alpha 1	208	Protein kinase.				cell division|mitosis|Wnt receptor signaling pathway	centrosome|condensed chromosome kinetochore|cytosol|nuclear speck	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(4)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		CAAAACATATCCTAATGATTC	0.333000													4	38					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75840598	75840598	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:75840598C>T	ENST00000322507.8	-	36	6346	c.6037G>A	c.(6037-6039)Gga>Aga	p.G2013R	COL12A1_ENST00000416123.2_Missense_Mutation_p.G2013R|COL12A1_ENST00000345356.6_Missense_Mutation_p.G849R|COL12A1_ENST00000483888.2_Missense_Mutation_p.G2013R	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2013	Fibronectin type-III 15.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CTGGGATTTCCCTCTCCATCC	0.542000													14	14					0	0	1	0	0
OR6M1	390261	broad.mit.edu	37	11	123676380	123676380	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:123676380G>A	ENST00000309154.2	-	1	715	c.678C>T	c.(676-678)ccC>ccT	p.P226P		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		CCTGGGTGGAGGGGATACGCA	0.498000													5	15					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70714062	70714062	+	RNA	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:70714062G>A	ENST00000530196.1	-	0	456					NR_003951.1																						CAGTCATCTGGGATGAAGAGC	0.468000													6	29					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103718360	103718360	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:103718360G>A	ENST00000245312.3	-	1	836	c.240C>T	c.(238-240)ccC>ccT	p.P80P		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	80					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ATCCTGTGAGGGGCATGATTC	0.527000													18	45					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	96058182	96058182	+	Silent	SNP	T	T	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:96058182T>G	ENST00000260766.3	+	24	5848	c.5214T>G	c.(5212-5214)ccT>ccG	p.P1738P	PLCE1_ENST00000371375.1_Silent_p.P1430P|PLCE1_ENST00000371385.3_Silent_p.P1430P|PLCE1_ENST00000371380.2_Silent_p.P1738P	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1738	PI-PLC Y-box.|Required for activation by RHOA, RHOB, GNA12, GNA13 and G-beta gamma (By similarity).				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				CTTCTTCCCCTCTCAACCCAA	0.453000													38	3					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179654825	179654825	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179654825C>T	ENST00000589042.1	-	12	2042	c.1818G>A	c.(1816-1818)agG>agA	p.R606R	TTN_ENST00000460472.2_Silent_p.R560R|TTN_ENST00000360870.5_Silent_p.R606R|TTN_ENST00000359218.5_Silent_p.R560R|TTN_ENST00000342175.6_Silent_p.R560R|TTN_ENST00000591111.1_Silent_p.R606R|TTN_ENST00000342992.6_Silent_p.R606R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	606							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAACTGTTTTCCTAGTTTCCT	0.313000													13	23					0	0	1	0	0
WASH3P	374666	broad.mit.edu	37	15	102516424	102516424	+	RNA	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:102516424G>T	ENST00000557932.1	+	0	1372																		p.P449P(4)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGCCGCCACCGCAGCAGCCAC	0.647000													5	42					0.184627	0.184627	1	1	0
GIMAP8	155038	broad.mit.edu	37	7	150171666	150171666	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:150171666G>A	ENST00000307271.3	+	4	1823	c.1249G>A	c.(1249-1251)Gaa>Aaa	p.E417K		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	417						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CGAGCTCCTGGAAAAAATTGA	0.403000													51	28					0	0	1	0	0
QRICH1	54870	broad.mit.edu	37	3	49114342	49114342	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:49114342T>A	ENST00000395443.2	-	2	581	c.109A>T	c.(109-111)Aag>Tag	p.K37*	QRICH1_ENST00000424300.1_Nonsense_Mutation_p.K37*|QRICH1_ENST00000357496.2_Nonsense_Mutation_p.K37*	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	37	CARD.									breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		TCTGGCCCCTTAGAGGCCAGT	0.527000													23	56					0	0	1	0	0
PSMD1	5707	broad.mit.edu	37	2	232010990	232010990	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:232010990C>T	ENST00000308696.6	+	18	2197	c.2035C>T	c.(2035-2037)Ccc>Tcc	p.P679S	PSMD1_ENST00000373635.4_Missense_Mutation_p.P679S|PSMD1_ENST00000409643.1_Missense_Mutation_p.P679S	NM_002807.3	NP_002798.2	Q99460	PSMD1_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	679					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)	31		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	GACAAACGACCCCGTGAACTA	0.383000													24	42					0	0	1	0	0
ZDHHC4	55146	broad.mit.edu	37	7	6628267	6628267	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:6628267C>T	ENST00000396706.2	+	8	1204	c.761C>T	c.(760-762)cCa>cTa	p.P254L	ZDHHC4_ENST00000335965.6_Missense_Mutation_p.P254L|ZDHHC4_ENST00000405731.3_Missense_Mutation_p.P254L|ZDHHC4_ENST00000396707.2_Missense_Mutation_p.P254L|AC079742.4_ENST00000434951.1_RNA|ZDHHC4_ENST00000396713.2_Missense_Mutation_p.P254L|ZDHHC4_ENST00000396709.1_Missense_Mutation_p.P254L			Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	254						integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)		CTGACTTTTCCACGGATTGTC	0.532000													49	85					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23863396	23863396	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:23863396C>T	ENST00000405093.3	-	21	2636	c.2566G>A	c.(2566-2568)Gaa>Aaa	p.E856K	MYH6_ENST00000356287.3_Missense_Mutation_p.E856K	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	856					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCGAACTCTTCCTTCATGGTG	0.562000													46	4					0	0	1	0	0
PLK3	1263	broad.mit.edu	37	1	45267296	45267296	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:45267296C>T	ENST00000372201.4	+	4	677	c.438C>T	c.(436-438)tcC>tcT	p.S146S	PLK3_ENST00000465443.1_3'UTR	NM_004073.2	NP_004064.2	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	146	Protein kinase.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					CTCTGCAGTCCCTGGCCCACA	0.642000													6	35					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175063237	175063237	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:175063237C>T	ENST00000239462.4	+	7	1549	c.1436C>T	c.(1435-1437)tCt>tTt	p.S479F		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	479	Fibronectin type-III 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CGCTACACTTCTGCTGATGGG	0.537000													12	22					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61747755	61747755	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:61747755C>T	ENST00000577390.1	-	10	2598	c.1644G>A	c.(1642-1644)aaG>aaA	p.K548K	CDH8_ENST00000580044.1_5'UTR|CDH8_ENST00000299345.6_Silent_p.K548K|CDH8_ENST00000577730.1_Silent_p.K548K	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	548	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CTTCATTTTTCTTGATGGTGA	0.313000													5	11					0	0	1	0	0
TOM1L2	146691	broad.mit.edu	37	17	17750954	17750954	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:17750954G>A	ENST00000581396.1	-	14	1465	c.1369C>T	c.(1369-1371)Ctg>Ttg	p.L457L	TOM1L2_ENST00000379504.3_Silent_p.L507L|TOM1L2_ENST00000542206.1_Silent_p.L388L|TOM1L2_ENST00000318094.10_Silent_p.L462L|TOM1L2_ENST00000540946.1_Silent_p.L389L|TOM1L2_ENST00000478943.1_Silent_p.L240L|TOM1L2_ENST00000395739.4_Silent_p.L462L|TOM1L2_ENST00000535933.1_Silent_p.L483L	NM_001033551.2	NP_001028723.1	Q6ZVM7	TM1L2_HUMAN	target of myb1-like 2 (chicken)	507					intracellular protein transport	intracellular				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(2)	10	all_neural(463;0.228)					GCTGCTCACAGGGCGAAGAGG	0.682000													25	11					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962840	73962840	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:73962840C>T	ENST00000373468.1	-	3	2203	c.1552G>A	c.(1552-1554)Gaa>Aaa	p.E518K	KIAA2022_ENST00000055682.5_Missense_Mutation_p.E518K			Q5QGS0	K2022_HUMAN	KIAA2022	518					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TCATCATCTTCCTCTTTGGAA	0.378000													13	26					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703474	4703474	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:4703474G>A	ENST00000396950.3	-	2	707	c.468C>T	c.(466-468)ttC>ttT	p.F156F		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		GAGGCAGTGGGAAAAAAAAGA	0.552000													10	17					0	0	1	0	0
OSM	5008	broad.mit.edu	37	22	30659929	30659929	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:30659929C>T	ENST00000215781.2	-	3	742	c.702G>A	c.(700-702)agG>agA	p.R234R	OSM_ENST00000403389.1_Silent_p.R213R	NM_020530.4	NP_065391.1	P13725	ONCM_HUMAN	oncostatin M	234					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|skin(3)	11			Epithelial(10;0.206)			AGGGTCTGGTCCTGCGCACCC	0.667000													85	91					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228553785	228553785	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:228553785C>T	ENST00000570156.2	+	94	22019	c.21945C>T	c.(21943-21945)tcC>tcT	p.S7315S	OBSCN_ENST00000422127.1_Silent_p.S6358S|OBSCN_ENST00000366707.4_Silent_p.S3992S	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	6358					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGCCCCCATCCATGCAGGTAA	0.627000													32	45					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29230622	29230622	+	RNA	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:29230622G>A	ENST00000441381.1	+	0	79																											AATGAGATGGGAGAAACAGGT	0.423000													40	40					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	41990568	41990568	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:41990568C>T	ENST00000372584.1	-	5	6235	c.5221G>A	c.(5221-5223)Gaa>Aaa	p.E1741K	HIVEP3_ENST00000460604.1_Intron|HIVEP3_ENST00000247584.5_Missense_Mutation_p.E1741K|HIVEP3_ENST00000372583.1_Missense_Mutation_p.E1741K|HIVEP3_ENST00000429157.2_Missense_Mutation_p.E1741K	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1741					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				ACATACTCTTCGTTTGATTTG	0.493000													9	37					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152426748	152426748	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:152426748C>T	ENST00000397345.3	-	109	17479	c.17277G>A	c.(17275-17277)caG>caA	p.Q5759Q	NEB_ENST00000603639.1_Silent_p.Q5759Q|NEB_ENST00000409198.1_Silent_p.Q4058Q|NEB_ENST00000172853.10_Silent_p.Q4058Q|NEB_ENST00000604864.1_Silent_p.Q5759Q|NEB_ENST00000427231.2_Silent_p.Q5759Q	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	5772					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCACAGGGCTCTGGATCTTGG	0.542000													7	24					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35852844	35852844	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:35852844C>A	ENST00000314607.6	+	12	2157	c.2077C>A	c.(2077-2079)Ctt>Att	p.L693I	ZMYM4_ENST00000373297.2_Missense_Mutation_p.L604I	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	693					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTGTAACCGTCTTTTTGCCAC	0.413000													20	9					7.45023e-12	7.56893e-12	1	1	0
KDM5B	10765	broad.mit.edu	37	1	202702925	202702925	+	Silent	SNP	G	G	A	rs141812947		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:202702925G>A	ENST00000367265.3	-	23	4677	c.3513C>T	c.(3511-3513)ctC>ctT	p.L1171L	KDM5B_ENST00000367264.2_Silent_p.L1207L	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	1171					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						CCACATCTTGGAGAGGCGACA	0.498000													27	57					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77763923	77763923	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:77763923A>T	ENST00000521891.2	+	10	5214	c.4766A>T	c.(4765-4767)gAt>gTt	p.D1589V	ZFHX4_ENST00000455469.2_Missense_Mutation_p.D1544V|ZFHX4_ENST00000518282.1_Missense_Mutation_p.D1563V|ZFHX4_ENST00000050961.6_Missense_Mutation_p.D1544V	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1544						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGCAACACAGATAACAAACCC	0.453000										HNSCC(33;0.089)			19	31					0	0	1	0	0
TRHR	7201	broad.mit.edu	37	8	110100524	110100524	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:110100524G>A	ENST00000518632.1	+	2	1134	c.783G>A	c.(781-783)agG>agA	p.R261R	TRHR_ENST00000311762.2_Silent_p.R261R			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	261						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			TATCTTCAAGGAAGCAGGTAA	0.383000													14	9					0	0	1	0	0
DNAJB8	165721	broad.mit.edu	37	3	128181722	128181722	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:128181722G>A	ENST00000469083.1	-	2	2924	c.367C>T	c.(367-369)Cgt>Tgt	p.R123C	DNAJB8_ENST00000319153.3_Missense_Mutation_p.R123C			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	123					protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		CGGCCACCACGGTCACTATTG	0.582000													28	10					0	0	1	0	0
OR6C70	390327	broad.mit.edu	37	12	55863590	55863590	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:55863590G>A	ENST00000327335.4	-	1	332	c.333C>T	c.(331-333)ttC>ttT	p.F111F	RP11-110A12.2_ENST00000555146.1_RNA|RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA	NM_001005499.1	NP_001005499.1	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C, member 70	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	18						CAGCTAGAAGGAAAAATTCTG	0.388000													15	25					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102955420	102955420	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:102955420G>A	ENST00000311734.2	+	3	524	c.185G>A	c.(184-186)aGa>aAa	p.R62K	IL1RL1_ENST00000404917.2_Intron|IL1RL1_ENST00000473175.1_3'UTR|IL1RL1_ENST00000393393.3_Missense_Mutation_p.R62K|IL1RL1_ENST00000409584.1_Missense_Mutation_p.R62K|IL1RL1_ENST00000233954.1_Missense_Mutation_p.R62K			Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	62	Ig-like C2-type 1.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						ACTCAGGAAAGAAATCGTGTG	0.393000													54	74					0	0	1	0	0
SNX20	124460	broad.mit.edu	37	16	50707515	50707515	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:50707515C>T	ENST00000330943.4	-	4	924	c.753G>A	c.(751-753)gaG>gaA	p.E251E	SNX20_ENST00000423026.2_Intron|SNX20_ENST00000300590.3_Intron	NM_182854.2	NP_878274.1	Q7Z614	SNX20_HUMAN	sorting nexin 20	251					cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(2)|stomach(1)	15						GCAGGGCCCTCTCTCCGGCCG	0.751000													13	15					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77288693	77288693	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:77288693C>T	ENST00000388914.3	-	11	1736	c.1584G>A	c.(1582-1584)ttG>ttA	p.L528L		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	528										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						CCTGCAATTTCAAGTCCACCC	0.488000													25	31					0	0	1	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48601490	48601490	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:48601490C>T	ENST00000354276.3	-	6	801	c.474G>A	c.(472-474)atG>atA	p.M158I	PLA2G4C_ENST00000599921.1_Missense_Mutation_p.M158I|PLA2G4C_ENST00000413144.2_Missense_Mutation_p.M158I|PLA2G4C_ENST00000599111.1_Missense_Mutation_p.M168I	NM_001159323.1	NP_001152795.1	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	158	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		CGGGCTTCTTCATATTGGACA	0.552000													29	18					0	0	1	0	0
C2orf48	348738	broad.mit.edu	37	2	10282434	10282434	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:10282434C>T	ENST00000381786.3	+	3	414	c.125C>T	c.(124-126)cCc>cTc	p.P42L		NM_182626.2	NP_872432.1	Q96LS8	CB048_HUMAN	chromosome 2 open reading frame 48	42										endometrium(1)|lung(7)	8	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)		aaagggaatcccctgcttctg	0.557000													83	46					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48613143	48613143	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:48613143C>T	ENST00000328333.8	-	72	6002	c.5895G>A	c.(5893-5895)gaG>gaA	p.E1965E	COL7A1_ENST00000454817.1_Silent_p.E1933E	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1965	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TACCAGAGCTCTCATCCCAGG	0.672000													20	34					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057898	9057898	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:9057898C>T	ENST00000397910.4	-	3	29751	c.29548G>A	c.(29548-29550)Gac>Aac	p.D9850N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9852	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGGTATCGTCCACAGCGGAG	0.473000													13	51					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242264025	242264025	+	Silent	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:242264025G>T	ENST00000442594.2	-	10	1532	c.1023C>A	c.(1021-1023)acC>acA	p.T341T	PLD5_ENST00000427495.1_Silent_p.T371T|PLD5_ENST00000536534.1_Silent_p.T433T	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	433						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			ACCTAGGAAAGGTGTGATTCT	0.428000													24	42					1.13719e-10	1.15207e-10	1	1	0
NBPF10	100132406	broad.mit.edu	37	1	145304477	145304477	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:145304477C>T	ENST00000342960.5	+	10	1445	c.1410C>T	c.(1408-1410)gtC>gtT	p.V470V	NBPF10_ENST00000369339.2_Silent_p.V199V|RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Silent_p.V199V	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	470										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AAAAGGAAGTCCCTGAGGACT	0.483000													40	142					0	0	1	0	0
CNR1	1268	broad.mit.edu	37	6	88854317	88854317	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:88854317C>T	ENST00000537554.1	-	2	4239	c.677G>A	c.(676-678)aGg>aAg	p.R226K	CNR1_ENST00000549890.1_Missense_Mutation_p.R226K|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000369499.2_Missense_Mutation_p.R226K|CNR1_ENST00000428600.2_Missense_Mutation_p.R226K|CNR1_ENST00000535130.1_Missense_Mutation_p.R226K|CNR1_ENST00000468898.1_Missense_Mutation_p.R193K|CNR1_ENST00000369501.2_Missense_Mutation_p.R226K|CNR1_ENST00000549716.1_Missense_Mutation_p.R165K	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	226					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	GGTGACAATCCTCTTATAGGC	0.597000													10	13					0	0	1	0	0
OR6C65	403282	broad.mit.edu	37	12	55795008	55795008	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:55795008G>A	ENST00000379665.2	+	1	795	c.696G>A	c.(694-696)agG>agA	p.R232R		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						CCCAGCAAAGGAAAAAGGCTT	0.398000													40	56					0	0	1	0	0
LYN	4067	broad.mit.edu	37	8	56911988	56911988	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:56911988C>T	ENST00000520220.2	+	12	1427	c.1153C>T	c.(1153-1155)Cct>Tct	p.P385S	LYN_ENST00000519728.1_Missense_Mutation_p.P406S	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	406	Protein kinase.		D -> Y (in a breast pleomorphic lobular carcinoma sample; somatic mutation).		erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			TGCTAAGTTCCCTATTAAGTG	0.373000													7	52					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102069922	102069922	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:102069922C>T	ENST00000369138.1	+	2	704	c.214C>T	c.(214-216)Ccc>Tcc	p.P72S	GRIK2_ENST00000318991.6_Missense_Mutation_p.P72S|GRIK2_ENST00000358361.3_Missense_Mutation_p.P72S|GRIK2_ENST00000421544.1_Missense_Mutation_p.P72S|GRIK2_ENST00000369134.4_Missense_Mutation_p.P23S|GRIK2_ENST00000369137.3_Missense_Mutation_p.P72S|GRIK2_ENST00000413795.1_Missense_Mutation_p.P72S	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	72					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	AACATTGCTACCCAATACTAC	0.363000													6	13					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143039598	143039598	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:143039598G>A	ENST00000343257.2	+	16	2017	c.1930_splice	c.e16+1	p.D644_splice		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	644	CBS 1.				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					TGACTCAAAAGGTCAGTGGGG	0.512000													24	19					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6173030	6173030	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:6173030G>A	ENST00000262450.3	-	34	5040	c.4941C>T	c.(4939-4941)atC>atT	p.I1647I	CHD5_ENST00000378021.1_Silent_p.I504I	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1647					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GCTTGTCCAGGATCTTCTCCT	0.577000													8	52					0	0	1	0	0
CAMK1D	57118	broad.mit.edu	37	10	12595230	12595230	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:12595230C>T	ENST00000378847.3	+	2	436	c.99C>T	c.(97-99)gcC>gcT	p.A33A	CAMK1D_ENST00000487696.1_Intron|CAMK1D_ENST00000378845.1_Silent_p.A33A	NM_153498.2	NP_705718.1	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	33	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)	16				GBM - Glioblastoma multiforme(1;3.16e-05)		ACAGCGGGGCCTTTTCCGAAG	0.463000													32	5					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94643191	94643191	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:94643191C>T	ENST00000260526.6	-	22	3064	c.2882G>A	c.(2881-2883)gGa>gAa	p.G961E	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	961					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		ATCACATTTTCCTAACGCATT	0.368000													17	42					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128781738	128781738	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:128781738C>T	ENST00000529694.1	+	2	946	c.570C>T	c.(568-570)atC>atT	p.I190I	KCNJ5_ENST00000338350.4_Silent_p.I190I|KCNJ5_ENST00000533599.1_Silent_p.I190I	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	190					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	TTGTCAAGATCAGCCAGCCCA	0.557000													33	37					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46245843	46245843	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:46245843C>T	ENST00000334344.6	+	15	4109	c.3937C>T	c.(3937-3939)Caa>Taa	p.Q1313*	ARID2_ENST00000444670.1_Nonsense_Mutation_p.Q923*|ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Nonsense_Mutation_p.Q1164*	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1313					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		AGGGAAAATTCAAAGTGAGAC	0.398000			"""N, S, F"""		hepatocellular carcinoma								17	3					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41203247	41203247	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:41203247C>T	ENST00000263413.3	-	2	350	c.86G>A	c.(85-87)tGg>tAg	p.W29*	C6_ENST00000337836.5_Nonsense_Mutation_p.W29*	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	29	TSP type-1 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CCACTGAGTCCATGCATAGTG	0.517000													63	77					0	0	1	0	0
SPZ1	84654	broad.mit.edu	37	5	79617301	79617301	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:79617301A>T	ENST00000296739.4	+	1	1512	c.1267A>T	c.(1267-1269)Atg>Ttg	p.M423L		NM_032567.3	NP_115956.3	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(5)|large_intestine(4)|lung(12)|ovary(1)|skin(2)	26		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		TAGGGGAAAAATGAGGTCAGC	0.373000													18	29					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14763875	14763875	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:14763875G>A	ENST00000358984.4	+	7	1191	c.1011G>A	c.(1009-1011)agG>agA	p.R337R	ANKRD30B_ENST00000579292.1_Intron|ANKRD30B_ENST00000447268.2_Silent_p.R337R	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	337										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						AAACACCTAGGAAAATTTTGA	0.418000													4	9					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179650650	179650650	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179650650C>T	ENST00000589042.1	-	14	2519	c.2295G>A	c.(2293-2295)aaG>aaA	p.K765K	TTN_ENST00000460472.2_Silent_p.K719K|TTN_ENST00000360870.5_Silent_p.K765K|TTN_ENST00000359218.5_Silent_p.K719K|TTN_ENST00000342175.6_Silent_p.K719K|TTN_ENST00000591111.1_Silent_p.K765K|TTN_ENST00000342992.6_Silent_p.K765K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	765							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTACTCTAGGCTTGACTGCTT	0.478000													25	22					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10951344	10951344	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr21:10951344G>A	ENST00000298232.7	-	9	681	c.314C>T	c.(313-315)cCt>cTt	p.P105L	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Missense_Mutation_p.P123L|TPTE_ENST00000342420.5_Missense_Mutation_p.P85L	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	123					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATACTCCAAAGGAATATAAAG	0.323000													5	48					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26423596	26423596	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:26423596G>A	ENST00000335473.7	+	43	7906	c.7656G>A	c.(7654-7656)agG>agA	p.R2552R	MYO18B_ENST00000407587.2_Silent_p.R2553R|MYO18B_ENST00000536101.1_Silent_p.R2552R	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2552						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GGACGGGGAGGAAAGACGACG	0.547000													8	6					0	0	1	0	0
CCDC114	93233	broad.mit.edu	37	19	48801292	48801292	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:48801292C>T	ENST00000315396.7	-	12	2038	c.1356G>A	c.(1354-1356)ccG>ccA	p.P452P		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	452								p.P245P(1)|p.P452P(1)		cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		CCATCTTCTTCGGAAGGTCCT	0.672000													17	12					0	0	1	0	0
RNF217	154214	broad.mit.edu	37	6	125284017	125284017	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:125284017G>A	ENST00000521654.2	+	1	327	c.327G>A	c.(325-327)gaG>gaA	p.E109E	RP11-510H23.1_ENST00000439075.1_RNA|RNF217_ENST00000560949.1_5'UTR			Q8TC41	RN217_HUMAN	ring finger protein 217	0					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		AGCTGGAGGAGGAAGAGGAGG	0.687000													6	19					0	0	1	0	0
SHE	126669	broad.mit.edu	37	1	154473970	154473970	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:154473970G>A	ENST00000304760.2	-	1	619	c.533C>T	c.(532-534)tCc>tTc	p.S178F		NM_001010846.2	NP_001010846.1	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	178	Ser-rich.									breast(4)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)	14	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			ggaggaaggggaagaggacgc	0.572000													27	23					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14754919	14754919	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:14754919C>T	ENST00000253673.5	-	9	1151		c.e9+1		EMR3_ENST00000344373.4_Splice_Site|EMR3_ENST00000443157.2_Splice_Site|EMR3_ENST00000599900.1_Splice_Site	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3						neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						ATACATCATACCTGGCTGGTC	0.423000													8	19					0	0	1	0	0
CLCN5	1184	broad.mit.edu	37	X	49855099	49855099	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:49855099C>T	ENST00000376088.3	+	13	2712	c.2071C>T	c.(2071-2073)Cca>Tca	p.P691S	CLCN5_ENST00000376091.3_Missense_Mutation_p.P691S|CLCN5_ENST00000376108.3_Missense_Mutation_p.P621S|CLCN5_ENST00000307367.2_Missense_Mutation_p.P621S	NM_001127898.1|NM_001127899.1	NP_001121370.1|NP_001121371.1	P51795	CLCN5_HUMAN	chloride channel, voltage-sensitive 5	621	CBS 2.				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)	30	Ovarian(276;0.236)					CAGTGGCTTCCCAGTGGTGGT	0.463000													10	12					0	0	1	0	0
C2orf62	375307	broad.mit.edu	37	2	219232510	219232510	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:219232510C>T	ENST00000289388.3	+	10	1016	c.987C>T	c.(985-987)tcC>tcT	p.S329S	C2orf62_ENST00000481940.1_3'UTR|AC021016.6_ENST00000441749.1_RNA	NM_198559.1	NP_940961.1	Q7Z7H3	CB062_HUMAN	chromosome 2 open reading frame 62	329										endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGCTCATCTCCGACTTCCTGC	0.706000													18	24					0	0	1	0	0
IQCB1	9657	broad.mit.edu	37	3	121518183	121518183	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:121518183G>A	ENST00000310864.6	-	8	840	c.626C>T	c.(625-627)tCa>tTa	p.S209L	IQCB1_ENST00000349820.6_Intron	NM_001023570.2	NP_001018864.2	Q15051	IQCB1_HUMAN	IQ motif containing B1	209					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding			NS(1)|biliary_tract(1)|breast(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)	30				GBM - Glioblastoma multiforme(114;0.0983)		ATCTAAAATTGAATACAGGGC	0.323000													7	6					0	0	1	0	0
UGT8	7368	broad.mit.edu	37	4	115544060	115544060	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:115544060C>T	ENST00000310836.6	+	2	546	c.24C>T	c.(22-24)ttC>ttT	p.F8F	UGT8_ENST00000394511.3_Silent_p.F8F	NM_001128174.1	NP_001121646.1	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	8					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		CTCCATATTTCATTCTCCTGT	0.383000													18	16					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20248715	20248715	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:20248715C>T	ENST00000315957.4	+	1	315	c.234C>T	c.(232-234)gcC>gcT	p.A78A		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	78					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCATTACAGCCCCTAAAATGC	0.443000													82	100					0	0	1	0	0
TF	7018	broad.mit.edu	37	3	133475789	133475789	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:133475789C>T	ENST00000402696.3	+	7	1291	c.806C>T	c.(805-807)aCc>aTc	p.T269I	TF_ENST00000264998.3_Missense_Mutation_p.T142I	NM_001063.3	NP_001054.1	P02787	TRFE_HUMAN	transferrin	269	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	CCTTCTCATACCGTCGTGGCC	0.587000													12	46					0	0	1	0	0
ZCCHC13	389874	broad.mit.edu	37	X	73524277	73524277	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:73524277A>G	ENST00000339534.2	+	1	253	c.176A>G	c.(175-177)aAc>aGc	p.N59S		NM_203303.2	NP_976048.1	Q8WW36	ZCH13_HUMAN	zinc finger, CCHC domain containing 13	59							nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	8						AATGCTAAGAACTGTGTCCTT	0.517000													10	32					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169586524	169586524	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:169586524C>T	ENST00000263686.6	-	3	260	c.223G>A	c.(223-225)Gaa>Aaa	p.E75K	SELP_ENST00000367793.2_Missense_Mutation_p.E75K|SELP_ENST00000367792.2_Missense_Mutation_p.E75K|SELP_ENST00000367791.2_Missense_Mutation_p.E75K|SELP_ENST00000367786.2_Missense_Mutation_p.E75K|SELP_ENST00000367788.2_Missense_Mutation_p.E75K|SELP_ENST00000367794.2_Missense_Mutation_p.E75K|SELP_ENST00000458599.2_Missense_Mutation_p.E75K	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	75	C-type lectin.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	TAATCAATTTCATTTTTATTC	0.403000													51	72					0	0	1	0	0
BPIFB3	359710	broad.mit.edu	37	20	31656616	31656616	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr20:31656616G>A	ENST00000375494.3	+	10	986	c.986G>A	c.(985-987)gGg>gAg	p.G329E		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	329					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										CAGGCCCTGGGGAAGCTGCCC	0.582000													11	29					0	0	1	0	0
EMILIN3	90187	broad.mit.edu	37	20	39992502	39992502	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr20:39992502C>T	ENST00000332312.3	-	3	483		c.e3-1			NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3							proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				TGTGCGGTACCTGGGCCAGGG	0.607000													37	22					0	0	1	0	0
STARD8	9754	broad.mit.edu	37	X	67937723	67937723	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:67937723G>A	ENST00000252336.6	+	5	1099	c.727G>A	c.(727-729)Gat>Aat	p.D243N	STARD8_ENST00000374597.3_Missense_Mutation_p.D243N|STARD8_ENST00000374599.3_Missense_Mutation_p.D323N	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	243					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						GTGTCCTGAGGATGGACACCG	0.647000													9	16					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075252	9075252	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:9075252G>A	ENST00000397910.4	-	3	12397	c.12194C>T	c.(12193-12195)tCt>tTt	p.S4065F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4067	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CGACCTCATAGACTGGGCAAG	0.483000													33	68					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35065949	35065949	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:35065949G>A	ENST00000382002.5	-	10	1537	c.1111C>T	c.(1111-1113)Ccc>Tcc	p.P371S	PRLR_ENST00000511486.1_Missense_Mutation_p.P270S|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000513753.1_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000342362.5_Missense_Mutation_p.P270S|PRLR_ENST00000310101.5_Intron|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000231423.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	371					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	AATGTGGAGGGATTGGCCTGG	0.527000													22	19					0	0	1	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135848596	135848596	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:135848596A>G	ENST00000264158.8	+	4	222	c.179A>G	c.(178-180)gAg>gGg	p.E60G	RAB3GAP1_ENST00000487003.1_3'UTR|RAB3GAP1_ENST00000442034.1_Missense_Mutation_p.E60G|RAB3GAP1_ENST00000539493.1_Missense_Mutation_p.E16G	NM_012233.2	NP_036365.1	Q15042	RB3GP_HUMAN	RAB3 GTPase activating protein subunit 1 (catalytic)	60						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32				BRCA - Breast invasive adenocarcinoma(221;0.117)		ACATGGGAAGAGAAATCAGAT	0.333000													36	34					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31855576	31855576	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:31855576G>A	ENST00000396184.3	-	16	1979	c.1775C>T	c.(1774-1776)tCc>tTc	p.S592F	PDE1C_ENST00000396191.1_Missense_Mutation_p.S592F|PDE1C_ENST00000396193.1_Missense_Mutation_p.S652F|PDE1C_ENST00000479980.1_5'UTR|PDE1C_ENST00000321453.7_Missense_Mutation_p.S592F|PDE1C_ENST00000396182.2_Missense_Mutation_p.S592F	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	592					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			CTCGGCTTTGGAGTTTTTCCC	0.453000													73	83					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6235746	6235746	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:6235746G>A	ENST00000265978.4	-	11	2852	c.2494C>T	c.(2494-2496)Cca>Tca	p.P832S	FAM160A2_ENST00000529360.1_5'UTR|FAM160A2_ENST00000449352.2_Missense_Mutation_p.P818S	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	818					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AGCAGTGCTGGGAAGTCCTCC	0.557000													28	34					0	0	1	0	0
MAP3K5	4217	broad.mit.edu	37	6	137019667	137019667	+	Missense_Mutation	SNP	G	G	A	rs145735047		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:137019667G>A	ENST00000359015.4	-	4	1126	c.766C>T	c.(766-768)Cgt>Tgt	p.R256C		NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	256					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding	p.R256C(1)		NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TGAATAAAACGATCCACAAGA	0.408000													14	17					0	0	1	0	0
GGT5	2687	broad.mit.edu	37	22	24621251	24621251	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:24621251C>T	ENST00000327365.4	-	10	1881	c.1465G>A	c.(1465-1467)Ggg>Agg	p.G489R	GGT5_ENST00000418439.2_Missense_Mutation_p.G413R|GGT5_ENST00000398292.3_Missense_Mutation_p.G490R|GGT5_ENST00000263112.7_Missense_Mutation_p.G457R	NM_001099781.1|NM_004121.2	NP_001093251.1|NP_004112.2	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5	489					glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity	p.G489R(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(3)|skin(3)	28						CCGCCAGCCCCGCCAATCACT	0.622000													46	51					0	0	1	0	0
NPY1R	4886	broad.mit.edu	37	4	164247268	164247268	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:164247268C>A	ENST00000296533.2	-	2	970	c.439G>T	c.(439-441)Ggg>Tgg	p.G147W	NPY1R_ENST00000509586.1_Intron	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	147					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GGTCTCCACCCTCGAGGGTTG	0.423000													20	30					1.15919e-05	1.16456e-05	1	1	0
ACAD8	27034	broad.mit.edu	37	11	134131190	134131190	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:134131190C>T	ENST00000281182.4	+	8	969	c.863C>T	c.(862-864)gCc>gTc	p.A288V	ACAD8_ENST00000543332.1_Missense_Mutation_p.A190V|ACAD8_ENST00000537423.1_Missense_Mutation_p.A211V|ACAD8_ENST00000374752.4_Missense_Mutation_p.A161V|ACAD8_ENST00000524547.1_3'UTR	NM_014384.2	NP_055199.1	Q9UKU7	ACAD8_HUMAN	acyl-CoA dehydrogenase family, member 8	288					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		CTGGGGGCTGCCCACGCCTCT	0.612000													15	32					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	148037456	148037456	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:148037456G>A	ENST00000370460.2	+	11	2360	c.1881G>A	c.(1879-1881)ggG>ggA	p.G627G	AFF2_ENST00000370457.5_Silent_p.G594G|AFF2_ENST00000342251.3_Silent_p.G594G|AFF2_ENST00000286437.5_Silent_p.G268G	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	627					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					GGACAATTGGGAAAAAACAGC	0.438000													58	74					0	0	1	0	0
TPK1	27010	broad.mit.edu	37	7	144245694	144245694	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:144245694C>T	ENST00000549981.1	-	10	875	c.150_splice	c.e10-1	p.G51_splice	TPK1_ENST00000538212.2_Splice_Site_p.G114_splice|TPK1_ENST00000378099.3_Splice_Site_p.G119_splice|TPK1_ENST00000360057.3_Splice_Site_p.G168_splice|TPK1_ENST00000547966.1_5'UTR			Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1	168					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			large_intestine(3)|lung(12)|ovary(2)|urinary_tract(2)	19					Thiamine(DB00152)	CCTGTGCTTTCCCTGAAGGAG	0.493000													10	37					0	0	1	0	0
ITGA2	3673	broad.mit.edu	37	5	52344306	52344306	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:52344306G>A	ENST00000296585.5	+	5	644	c.502_splice	c.e5+1	p.Q167_splice		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	167					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				CTGCAACTCAGCGTAAGTTAT	0.468000													27	26					0	0	1	0	0
BACH2	60468	broad.mit.edu	37	6	90661173	90661173	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:90661173C>T	ENST00000257749.4	-	7	1359	c.652G>A	c.(652-654)Gag>Aag	p.E218K	RP3-512E2.2_ENST00000413986.1_RNA|BACH2_ENST00000343122.3_Missense_Mutation_p.E218K|RP3-512E2.2_ENST00000445838.1_RNA|BACH2_ENST00000537989.1_Missense_Mutation_p.E218K	NM_021813.2	NP_068585.1	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 2	218						nucleus	protein dimerization activity|sequence-specific DNA binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	45		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TCTGAGCTCTCCTTGGTGTCT	0.537000													23	27					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46657909	46657909	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:46657909C>T	ENST00000253255.5	-	1	1310	c.1311G>A	c.(1309-1311)aaG>aaA	p.K437K		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	437	REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TCCTAGAGTCCTTCCGAATCA	0.478000													30	38					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50958778	50958778	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:50958778G>A	ENST00000357701.5	+	20	2266	c.2215G>A	c.(2215-2217)Gaa>Aaa	p.E739K		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	739	Fibronectin type-III 2.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		ACCCACGAGTGAACCCCTGCA	0.572000													45	36					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43307400	43307400	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:43307400G>A	ENST00000361428.2	-	10	4413	c.4336C>T	c.(4336-4338)Cca>Tca	p.P1446S	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1446	Pro-rich.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			ggtgggggtggtggaggaggt	0.507000													19	13					0	0	1	0	0
IL1RL2	8808	broad.mit.edu	37	2	102805721	102805721	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:102805721T>A	ENST00000264257.2	+	3	370	c.244T>A	c.(244-246)Ttt>Att	p.F82I	IL1RL2_ENST00000539491.1_Missense_Mutation_p.F82I|IL1RL2_ENST00000481806.1_Intron|IL1RL2_ENST00000441515.2_Intron	NM_003854.2	NP_003845.2	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2	82	Ig-like C2-type 1.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|liver(2)|lung(8)|ovary(2)|prostate(1)	26						TTGGATTTTGTTTCTCCCCAT	0.373000													9	19					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179701873	179701873	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179701873G>A	ENST00000420890.2	-	23	4190	c.4073C>T	c.(4072-4074)aCc>aTc	p.T1358I	CCDC141_ENST00000480419.1_5'UTR|CCDC141_ENST00000295723.5_Missense_Mutation_p.T783I	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	783							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CCTATCTTGGGTTTTAGTGAA	0.498000													19	14					0	0	1	0	0
HAPLN1	1404	broad.mit.edu	37	5	82969277	82969277	+	Nonsense_Mutation	SNP	A	A	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:82969277A>C	ENST00000274341.4	-	2	916	c.66T>G	c.(64-66)taT>taG	p.Y22*	HAPLN1_ENST00000514416.1_Nonsense_Mutation_p.Y22*	NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	22					cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		GATCCAGAGTATAGTTGTCTG	0.393000													29	33					0	0	1	0	0
SWT1	54823	broad.mit.edu	37	1	185175889	185175889	+	Missense_Mutation	SNP	C	C	T	rs145355483		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:185175889C>T	ENST00000367500.4	+	13	2131	c.1966C>T	c.(1966-1968)Cgt>Tgt	p.R656C	SWT1_ENST00000367501.3_Missense_Mutation_p.R656C	NM_017673.6	NP_060143.4	Q5T5J6	SWT1_HUMAN	SWT1 RNA endoribonuclease homolog (S. cerevisiae)	656										breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(16)|ovary(1)|prostate(1)|urinary_tract(1)	41						CAAAAATCTCCGTAAAGGTAT	0.303000													13	20					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76657030	76657030	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:76657030C>T	ENST00000369963.3	-	14	4471		c.e14+1		IMPG1_ENST00000369950.3_Splice_Site			Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1						visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GATTCTTTTACCTGGTTCAAT	0.418000													6	10					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100569567	100569567	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:100569567G>A	ENST00000471714.1	-	16	1493	c.1384C>T	c.(1384-1386)Cgt>Tgt	p.R462C	ABI3BP_ENST00000495063.1_Missense_Mutation_p.R462C|ABI3BP_ENST00000284322.5_Missense_Mutation_p.R413C			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	424	Pro-rich.					extracellular space		p.R413C(1)		central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						TCCAGAATACGATCACTTGTT	0.343000													10	13					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133152366	133152366	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:133152366C>T	ENST00000388996.4	-	11	1945	c.1525G>A	c.(1525-1527)Gaa>Aaa	p.E509K	KCNQ3_ENST00000521134.1_Missense_Mutation_p.E389K|KCNQ3_ENST00000519445.1_Missense_Mutation_p.E509K	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	509					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			ATCATGTCTTCGATGGGGAAG	0.627000													27	46					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50099988	50099988	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:50099988C>T	ENST00000418929.2	+	4	2408	c.2396C>T	c.(2395-2397)cCc>cTc	p.P799L		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	490							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CCGCCTCCCCCCCAGCTGCTC	0.721000													8	11					0	0	1	0	0
SPHK2	56848	broad.mit.edu	37	19	49129485	49129485	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:49129485G>A	ENST00000443164.1	+	1	1268	c.563G>A	c.(562-564)gGg>gAg	p.G188E	SPHK2_ENST00000599029.1_Missense_Mutation_p.G90E|SPHK2_ENST00000601712.1_Missense_Mutation_p.G90E|SPHK2_ENST00000599748.1_Missense_Mutation_p.G90E|SPHK2_ENST00000599033.1_3'UTR|SPHK2_ENST00000598088.1_Missense_Mutation_p.G126E|SPHK2_ENST00000600537.1_Missense_Mutation_p.G67E|SPHK2_ENST00000245222.4_Missense_Mutation_p.G126E|SPHK2_ENST00000340932.3_Missense_Mutation_p.G90E			Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	126	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		ggccggcgcggggcccggcgc	0.706000													14	6					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122625192	122625192	+	Silent	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:122625192T>C	ENST00000263461.6	+	7	1176	c.930T>C	c.(928-930)ggT>ggC	p.G310G		NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	310						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						ATGAAAATGGTTGTATAACTT	0.279000													11	0					0	0	1	0	0
UGT2A2	574537	broad.mit.edu	37	4	70505031	70505031	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:70505031G>A	ENST00000457664.2	-	1	327	c.328C>T	c.(328-330)Cct>Tct	p.P110S	UGT2A1_ENST00000503640.1_Intron|UGT2A1_ENST00000286604.4_Intron|UGT2A1_ENST00000512704.1_Intron|UGT2A1_ENST00000514019.1_Missense_Mutation_p.P311S	NM_001105677.2	NP_001099147.2																					ATTGTGAGAGGAGTTGGTCTA	0.358000													22	16					0	0	1	0	0
MKRN2	23609	broad.mit.edu	37	3	12623639	12623639	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:12623639G>A	ENST00000170447.7	+	8	1275	c.1138G>A	c.(1138-1140)Gat>Aat	p.D380N	MKRN2_ENST00000448482.1_Missense_Mutation_p.D378N|MKRN2_ENST00000411987.1_Missense_Mutation_p.D337N	NM_001271707.1|NM_014160.3	NP_001258636.1|NP_054879.3	Q9H000	MKRN2_HUMAN	makorin ring finger protein 2	380						intracellular	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(3)	16						GCGGCTCTGGGATTTCATCGA	0.498000													115	91					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4825098	4825098	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:4825098G>A	ENST00000380382.1	-	1	749	c.750C>T	c.(748-750)ttC>ttT	p.F250F	OR52R1_ENST00000356069.2_Silent_p.F171F|MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGTGTTGGCAGAAGGGCATCC	0.547000													10	21					0	0	1	0	0
KIAA1024	23251	broad.mit.edu	37	15	79750313	79750313	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:79750313G>A	ENST00000305428.3	+	2	1899	c.1824G>A	c.(1822-1824)cgG>cgA	p.R608R		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	608						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						AAATTGAACGGAAGCTGGAAT	0.512000													31	26					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15728902	15728902	+	RNA	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:15728902C>T	ENST00000441682.2	+	0	354							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CCCATCACTCCCATCATCAAC	0.587000													50	57					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54806472	54806472	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:54806472G>A	ENST00000306858.7	+	5	2819	c.2703G>A	c.(2701-2703)gaG>gaA	p.E901E		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	901										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					ATTCAAGGGAGATTAATGCAG	0.468000													10	15					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11732302	11732302	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:11732302C>T	ENST00000304623.8	-	2	309	c.120G>A	c.(118-120)ggG>ggA	p.G40G	CTNND2_ENST00000458100.2_5'UTR|CTNND2_ENST00000359640.2_Silent_p.G40G	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	40					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						CAGAGCCATCCCCGTTGGAGG	0.507000													23	26					0	0	1	0	0
ACAD8	27034	broad.mit.edu	37	11	134126487	134126487	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:134126487C>T	ENST00000281182.4	+	2	261	c.155C>T	c.(154-156)gCc>gTc	p.A52V	ACAD8_ENST00000543332.1_Missense_Mutation_p.P11S|ACAD8_ENST00000537423.1_Intron|ACAD8_ENST00000374752.4_Intron|ACAD8_ENST00000524547.1_Intron	NM_014384.2	NP_055199.1	Q9UKU7	ACAD8_HUMAN	acyl-CoA dehydrogenase family, member 8	52					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		CAAAAAGTGGCCTTTGACTTT	0.468000													9	9					0	0	1	0	0
PCGF5	84333	broad.mit.edu	37	10	93000322	93000322	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:93000322C>T	ENST00000336126.5	+	3	426	c.194C>T	c.(193-195)cCa>cTa	p.P65L	PCGF5_ENST00000543648.1_Missense_Mutation_p.P65L	NM_001257101.1|NM_032373.4	NP_001244030.1|NP_115749.2	Q86SE9	PCGF5_HUMAN	polycomb group ring finger 5	65					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|PcG protein complex	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)	12						GAGACAAATCCATTAGAAATG	0.313000													8	19					0	0	1	0	0
RAB27B	5874	broad.mit.edu	37	18	52551603	52551603	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:52551603G>A	ENST00000262094.5	+	4	800	c.279G>A	c.(277-279)atG>atA	p.M93I	RAB27B_ENST00000586594.1_Intron	NM_004163.4	NP_004154.2	O00194	RB27B_HUMAN	RAB27B, member RAS oncogene family	93					protein transport|small GTPase mediated signal transduction	Golgi apparatus|plasma membrane	GTP binding|GTPase activity			large_intestine(3)|lung(3)|skin(1)	7				Colorectal(16;0.0273)|READ - Rectum adenocarcinoma(59;0.219)		GAGACGCCATGGGCTTCTTAT	0.448000													22	24					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57731656	57731656	+	Missense_Mutation	SNP	C	C	T	rs144501542		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:57731656C>T	ENST00000281282.5	+	2	1537	c.1459C>T	c.(1459-1461)Ctt>Ttt	p.L487F		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	487	Head.					myosin complex|tight junction	motor activity	p.L487F(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TGCGCCCTCCCTTGGTGCACA	0.547000													26	15					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185161233	185161233	+	Splice_Site	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:185161233G>T	ENST00000265026.3	+	4	994	c.659_splice	c.e4-1	p.K220_splice	MAP3K13_ENST00000424227.1_Splice_Site_p.K220_splice|MAP3K13_ENST00000443863.1_Splice_Site_p.K76_splice|MAP3K13_ENST00000535426.1_Splice_Site_p.K76_splice|MAP3K13_ENST00000446828.1_Splice_Site_p.R13_splice	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	220	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TTCTTGGAAGGGGTGTTTGTA	0.363000													5	26					0.0215528	0.0215727	1	1	0
C8orf34	116328	broad.mit.edu	37	8	69351755	69351755	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:69351755A>G	ENST00000337103.4	+	1	1608	c.16A>G	c.(16-18)Act>Gct	p.T6A	C8orf34_ENST00000349492.3_3'UTR|C8orf34_ENST00000518698.1_Missense_Mutation_p.T117A|C8orf34_ENST00000348340.2_Missense_Mutation_p.T31A|C8orf34_ENST00000523686.1_Missense_Mutation_p.T31A|C8orf34_ENST00000539993.1_Missense_Mutation_p.T31A			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	31					signal transduction		cAMP-dependent protein kinase regulator activity			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CAAGTTAATAACTGAGACACC	0.383000													30	17					0	0	1	0	0
RGAG4	340526	broad.mit.edu	37	X	71349823	71349823	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:71349823G>A	ENST00000545866.1	-	1	1935	c.1568C>T	c.(1567-1569)tCa>tTa	p.S523L	NHSL2_ENST00000540800.1_Intron|RGAG4_ENST00000479991.1_Missense_Mutation_p.S523L			Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	523										cervix(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|skin(1)	24	Renal(35;0.156)					GTAGAATGGTGAATTGGTGCC	0.562000													21	24					0	0	1	0	0
MRPL23	6150	broad.mit.edu	37	11	1977616	1977616	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:1977616G>T	ENST00000397298.3	+	5	513	c.428G>T	c.(427-429)cGg>cTg	p.R143L	MRPL23_ENST00000381514.3_Intron|MRPL23_ENST00000397294.3_Intron|MRPL23_ENST00000397297.3_Intron|MRPL23_ENST00000381519.1_Missense_Mutation_p.R143L	NM_021134.3	NP_066957.3	Q16540	RM23_HUMAN	mitochondrial ribosomal protein L23	143					translation	mitochondrial large ribosomal subunit	nucleotide binding|RNA binding|structural constituent of ribosome			large_intestine(2)|lung(1)|ovary(1)	4		all_epithelial(84;6.24e-05)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.0026)|Lung(200;0.0171)|LUSC - Lung squamous cell carcinoma(625;0.0842)		AGCGACCCGCGGCGGGGCGGC	0.716000													12	11					1.08611e-07	1.0952e-07	1	1	0
FOXK2	3607	broad.mit.edu	37	17	80521332	80521332	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:80521332C>T	ENST00000335255.5	+	2	696	c.522C>T	c.(520-522)gcC>gcT	p.A174A		NM_004514.3	NP_004505.2	Q01167	FOXK2_HUMAN	forkhead box K2	174					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	17	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			CAGTGAAGGCCGTACAGCCAC	0.587000													12	27					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16026301	16026301	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:16026301C>T	ENST00000350896.3	-	4	493	c.296G>A	c.(295-297)gGa>gAa	p.G99E	MSR1_ENST00000262101.5_Missense_Mutation_p.G99E|MSR1_ENST00000445506.2_Missense_Mutation_p.G117E|MSR1_ENST00000536385.1_Intron|MSR1_ENST00000355282.2_Missense_Mutation_p.G99E|MSR1_ENST00000381998.4_Missense_Mutation_p.G99E	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	99	Spacer (Probable).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATTTCCTTTTCCCGTGAGACT	0.358000													48	39					0	0	1	0	0
IRAK1	3654	broad.mit.edu	37	X	153284189	153284189	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:153284189G>A	ENST00000369980.3	-	5	757	c.590C>T	c.(589-591)cCg>cTg	p.P197L	IRAK1_ENST00000429936.2_Missense_Mutation_p.P223L|IRAK1_ENST00000393687.2_Missense_Mutation_p.P197L|IRAK1_ENST00000393682.1_Missense_Mutation_p.P223L|IRAK1_ENST00000369974.2_Missense_Mutation_p.P197L	NM_001025242.1|NM_001569.3	NP_001020413.1|NP_001560.2	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	197	ProST region.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(15)|ovary(2)	25	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCAGCAAAACGGAAAGGGGCG	0.642000													31	28					0	0	1	0	0
USP17L2	377630	broad.mit.edu	37	8	11995136	11995136	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:11995136C>T	ENST00000333796.3	-	1	1450	c.1134G>A	c.(1132-1134)tgG>tgA	p.W378*	FAM66D_ENST00000434078.2_RNA	NM_001256869.1|NM_001256871.1|NM_001256872.1|NM_001256873.1|NM_001256874.1|NM_201402.2	NP_001243798.1|NP_001243800.1|NP_001243801.1|NP_001243802.1|NP_001243803.1|NP_958804.2	Q6R6M4	U17L2_HUMAN	ubiquitin specific peptidase 17-like family member 2	378					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(1)|kidney(1)|large_intestine(11)|liver(1)|lung(8)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	29						TGTGTCTTTCCCATTCACTCT	0.512000													6	64					0	0	1	0	0
CLRN2	645104	broad.mit.edu	37	4	17517087	17517087	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:17517087C>T	ENST00000511148.2	+	1	300	c.198C>T	c.(196-198)ttC>ttT	p.F66F		NM_001079827.2	NP_001073296.1	A0PK11	CLRN2_HUMAN	clarin 2	66						integral to membrane				breast(1)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|upper_aerodigestive_tract(1)	15						ACGGGCTCTTCCGAGGGTGTA	0.517000													25	23					0	0	1	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254886	30254886	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:30254886A>G	ENST00000361644.2	+	5	1582	c.845A>G	c.(844-846)gAa>gGa	p.E282G	MAGEB3_ENST00000378986.1_Missense_Mutation_p.E282G	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	282	MAGE.									NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						GCCCATGCTGAAACCAGCAAG	0.488000													9	52					0	0	1	0	0
FAM155B	27112	broad.mit.edu	37	X	68749603	68749603	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:68749603C>T	ENST00000252338.4	+	3	1265	c.1223C>T	c.(1222-1224)cCa>cTa	p.P408L		NM_015686.2	NP_056501.2	O75949	F155B_HUMAN	family with sequence similarity 155, member B	409						integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)	16						caTGATCCCCCAGGCCGTGTC	0.612000													21	23					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615354	179615354	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179615354C>T	ENST00000360870.5	-	46	11995	c.11773G>A	c.(11773-11775)Gaa>Aaa	p.E3925K	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000589042.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9745							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTTTTCTTCCTTCTGTTCG	0.338000													18	16					0	0	1	0	0
HSF2BP	11077	broad.mit.edu	37	21	45076493	45076493	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr21:45076493G>A	ENST00000291560.2	-	3	493	c.162C>T	c.(160-162)ttC>ttT	p.F54F	HSF2BP_ENST00000542962.1_Intron	NM_007031.1	NP_008962.1	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding protein	54					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			kidney(2)|large_intestine(3)|prostate(1)|skin(1)	7				STAD - Stomach adenocarcinoma(101;0.18)		TTAATTTCTGGAAGCTCTCCA	0.388000													7	43					0	0	1	0	0
KRBA1	84626	broad.mit.edu	37	7	149419603	149419603	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:149419603G>A	ENST00000255992.10	+	6	956	c.557G>A	c.(556-558)aGg>aAg	p.R186K	KRBA1_ENST00000479560.1_3'UTR|KRBA1_ENST00000485033.2_Missense_Mutation_p.R186K|KRBA1_ENST00000319551.8_Missense_Mutation_p.R186K	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	186										breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCCAGCAGGAGGAAGAGCCAC	0.622000													9	11					0	0	1	0	0
EPS15L1	58513	broad.mit.edu	37	19	16535919	16535919	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:16535919G>A	ENST00000602009.1	-	3	1200	c.305C>T	c.(304-306)cCc>cTc	p.P102L	EPS15L1_ENST00000455140.2_Missense_Mutation_p.P256L|EPS15L1_ENST00000594975.1_Missense_Mutation_p.P256L|EPS15L1_ENST00000535753.2_Missense_Mutation_p.P256L|EPS15L1_ENST00000597937.1_Missense_Mutation_p.P256L|EPS15L1_ENST00000248070.6_Missense_Mutation_p.P256L			Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	256	EH 1.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						GCTGTGCTTGGGGGACAGGCT	0.632000													22	37					0	0	1	0	0
RSPH1	89765	broad.mit.edu	37	21	43897468	43897468	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr21:43897468C>T	ENST00000291536.3	-	7	827	c.660G>A	c.(658-660)tgG>tgA	p.W220*	RSPH1_ENST00000398352.3_Nonsense_Mutation_p.W182*	NM_080860.2	NP_543136.1	Q8WYR4	RSPH1_HUMAN	radial spoke head 1 homolog (Chlamydomonas)	220					meiosis	cytosol|nucleus				large_intestine(7)|lung(2)|ovary(1)|prostate(1)|stomach(1)	12						GAGTTGGTGTCCACAGGGCCA	0.532000													17	30					0	0	1	0	0
RSF1	51773	broad.mit.edu	37	11	77436740	77436740	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:77436740G>A	ENST00000308488.6	-	5	885	c.583C>T	c.(583-585)Cga>Tga	p.R195*	RSF1_ENST00000360355.2_Nonsense_Mutation_p.R164*			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	195					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			AACTCGTTTCGATTTCTAAAC	0.338000													6	8					0	0	1	0	0
SULT4A1	25830	broad.mit.edu	37	22	44258218	44258218	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:44258218G>A	ENST00000330884.4	-	1	165	c.45C>T	c.(43-45)ttC>ttT	p.F15F	SULT4A1_ENST00000540422.1_Silent_p.F15F|SULT4A1_ENST00000249130.5_Silent_p.F15F	NM_014351.3	NP_055166.1	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	15					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		ACTTGCTCTCGAACTCCCCCG	0.736000													48	41					0	0	1	0	0
AURKAIP1	54998	broad.mit.edu	37	1	1309550	1309550	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:1309550C>A	ENST00000338370.3	-	2	728	c.328G>T	c.(328-330)Gaa>Taa	p.E110*	AURKAIP1_ENST00000321751.5_Nonsense_Mutation_p.E110*|AURKAIP1_ENST00000378853.3_Nonsense_Mutation_p.E110*|AURKAIP1_ENST00000338338.5_Nonsense_Mutation_p.E110*			Q9NWT8	AKIP_HUMAN	aurora kinase A interacting protein 1	110					negative regulation of mitosis|positive regulation of proteolysis	mitochondrion|nucleus	protein binding			kidney(1)|lung(2)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.82e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TCGGCCCCTTCCCCTATCTGG	0.627000													83	35					9.54843e-35	9.75541e-35	1	1	0
COL9A1	1297	broad.mit.edu	37	6	71003913	71003913	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:71003913G>A	ENST00000357250.6	-	5	811	c.653C>T	c.(652-654)gCt>gTt	p.A218V	COL9A1_ENST00000370496.3_Missense_Mutation_p.A218V	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	218	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						TCCCAGCACAGCAAAGCCATC	0.398000													17	32					0	0	1	0	0
HRASLS5	117245	broad.mit.edu	37	11	63235895	63235895	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:63235895G>A	ENST00000540857.1	-	4	520	c.388C>T	c.(388-390)Cga>Tga	p.R130*	HRASLS5_ENST00000539221.1_Nonsense_Mutation_p.R140*|HRASLS5_ENST00000301790.4_Nonsense_Mutation_p.R140*	NM_001146728.1|NM_001146729.1|NM_054108.3	NP_001140200.1|NP_001140201.1|NP_473449.1	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5	140										endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	14						TAGCCAATTCGAAAAATCTCA	0.418000													16	20					0	0	1	0	0
DDX27	55661	broad.mit.edu	37	20	47835926	47835926	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr20:47835926G>A	ENST00000371764.4	+	1	43	c.34G>A	c.(34-36)Gaa>Aaa	p.E12K	DDX27_ENST00000484427.1_3'UTR	NM_017895.7	NP_060365.7	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	12						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AGGAGGCTGCGAAAAGTTAAG	0.607000													4	15					0	0	1	0	0
ATP5B	506	broad.mit.edu	37	12	57037238	57037238	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:57037238G>A	ENST00000262030.3	-	5	791	c.741C>T	c.(739-741)taC>taT	p.Y247Y	ATP5B_ENST00000552919.1_Silent_p.Y247Y	NM_001686.3	NP_001677.2	P06576	ATPB_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	247					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TCATTTCATGGTATAAATCAT	0.428000													40	35					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628523	173628523	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:173628523G>A	ENST00000333279.2	-	2	95	c.35C>T	c.(34-36)tCa>tTa	p.S12L		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	28										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						GAAAAATTCTGAACTCTCTGA	0.393000													12	16					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3299467	3299467	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:3299467C>T	ENST00000219596.1	-	3	1263	c.1224G>A	c.(1222-1224)cgG>cgA	p.R408R	MEFV_ENST00000536379.1_Silent_p.R197R|MEFV_ENST00000541159.1_Silent_p.R197R|MEFV_ENST00000339854.4_Silent_p.R228R	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	408			R -> Q (in arFMF; associated with Q-148 and S-369 in cis; could be a polymorphism; dbSNP:rs11466024).		inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	TGGGGCGCACCCGGTGGCCTT	0.602000													25	44					0	0	1	0	0
UBE2A	7319	broad.mit.edu	37	X	118708942	118708942	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:118708942C>T	ENST00000371558.2	+	2	297	c.123C>T	c.(121-123)ttC>ttT	p.F41F	UBE2A_ENST00000469205.1_3'UTR|UBE2A_ENST00000346330.3_Silent_p.F41F	NM_003336.2|NM_181762.1	NP_003327.2|NP_861427.1	P49459	UBE2A_HUMAN	ubiquitin-conjugating enzyme E2A	41					histone H2A ubiquitination|positive regulation of cell proliferation|postreplication repair|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|response to UV|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity			haematopoietic_and_lymphoid_tissue(1)|lung(7)	8						CGGTCATTTTCGGGTGAGTCT	0.662000								Rad6 pathway					37	40					0	0	1	0	0
NCF4	4689	broad.mit.edu	37	22	37273838	37273838	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:37273838C>T	ENST00000248899.6	+	10	1177	c.993C>T	c.(991-993)aaC>aaT	p.N331N	NCF4_ENST00000397147.4_3'UTR	NM_000631.4	NP_000622.2	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4, 40kDa	331					cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			cervix(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						AGAAGGACAACTACAGGGTCT	0.597000													5	20					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72164554	72164554	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:72164554C>T	ENST00000537465.1	-	11	1688	c.1530G>A	c.(1528-1530)agG>agA	p.R510R	PMFBP1_ENST00000355636.6_Silent_p.R360R|PMFBP1_ENST00000237353.10_Silent_p.R505R			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	510										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				TCTGCAGTTTCCTCTGGGTGT	0.567000													30	29					0	0	1	0	0
TMEM100	55273	broad.mit.edu	37	17	53798372	53798372	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:53798372C>T	ENST00000575734.1	-	4	868	c.60G>A	c.(58-60)acG>acA	p.T20T	TMEM100_ENST00000424486.2_Silent_p.T20T	NM_001099640.1	NP_001093110.1	Q9NV29	TM100_HUMAN	transmembrane protein 100	20						integral to membrane				cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	11						TCTTCTCCATCGTCGCTGCCA	0.522000													27	64					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108010917	108010917	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:108010917G>A	ENST00000280758.5	+	8	2581	c.2053G>A	c.(2053-2055)Gag>Aag	p.E685K	RP11-128P10.1_ENST00000548473.1_RNA|BTBD11_ENST00000357167.4_Missense_Mutation_p.E222K|BTBD11_ENST00000490090.2_Missense_Mutation_p.E685K|BTBD11_ENST00000420571.2_Missense_Mutation_p.E685K	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	685						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GCATGGCGAGGAGAACTACTC	0.607000													38	9					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37622085	37622085	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:37622085T>C	ENST00000434837.2	-	6	2125	c.947A>G	c.(946-948)aAc>aGc	p.N316S	MDGA1_ENST00000505425.1_Missense_Mutation_p.N316S|MDGA1_ENST00000297153.7_Missense_Mutation_p.N316S	NM_153487.3	NP_705691.1	Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	316	Ig-like 3.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						CTTGGCAGGGTTGCCCACATT	0.612000											OREG0017405	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	10					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41450653	41450653	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr21:41450653C>T	ENST00000400454.1	-	26	5149	c.4672G>A	c.(4672-4674)Gag>Aag	p.E1558K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1558	Fibronectin type-III 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCCTGCTTCTCCGCGCAGCCC	0.587000													12	12					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31294300	31294300	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:31294300G>A	ENST00000265071.2	+	3	725	c.460G>A	c.(460-462)Gac>Aac	p.D154N	CDH6_ENST00000514738.1_Missense_Mutation_p.D99N	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	154	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TGACATCAATGACAATGAACC	0.468000													73	73					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3238772	3238772	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:3238772G>A	ENST00000217939.6	-	5	5108	c.4954C>T	c.(4954-4956)Cct>Tct	p.P1652S		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1652						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCCCCAGAAGGATATGTAGTT	0.453000													90	100					0	0	1	0	0
GPR34	2857	broad.mit.edu	37	X	41555494	41555494	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:41555494T>G	ENST00000378142.4	+	3	892	c.608T>G	c.(607-609)aTg>aGg	p.M203R	CASK_ENST00000378154.1_Intron|CASK_ENST00000361962.4_Intron|GPR34_ENST00000378138.5_Missense_Mutation_p.M203R|CASK_ENST00000421587.2_Intron|CASK_ENST00000318588.9_Intron|CASK_ENST00000378158.1_Intron|CASK_ENST00000378166.4_Intron|CASK_ENST00000442742.2_Intron|CASK_ENST00000378163.1_Intron	NM_001097579.1|NM_005300.3	NP_001091048.1|NP_005291.1	Q9UPC5	GPR34_HUMAN	G protein-coupled receptor 34	203						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(1)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	14						AATTCCACAATGTGTTTCCAT	0.333000													13	32					0	0	1	0	0
FHL5	9457	broad.mit.edu	37	6	97051540	97051540	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:97051540G>A	ENST00000326771.2	+	3	431	c.51G>A	c.(49-51)ggG>ggA	p.G17G	FHL5_ENST00000541107.1_Silent_p.G17G	NM_020482.4	NP_065228.4	Q5TD97	FHL5_HUMAN	four and a half LIM domains 5	17						nucleus	zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|urinary_tract(1)	27		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		CACTTCTTGGGAAGAAATATG	0.343000													7	14					0	0	1	0	0
FAM131B	9715	broad.mit.edu	37	7	143056102	143056102	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:143056102A>T	ENST00000409408.1	-	4	1908	c.200T>A	c.(199-201)aTg>aAg	p.M67K	FAM131B_ENST00000409346.1_Missense_Mutation_p.M67K|FAM131B_ENST00000443739.2_Missense_Mutation_p.M95K|FAM131B_ENST00000409222.3_Missense_Mutation_p.M67K|FAM131B_ENST00000409578.1_Missense_Mutation_p.M83K			Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	67										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					ATGGTCCTTCATGCTCCGTGA	0.582000													17	10					0	0	1	0	0
TRAV13-1	28671	broad.mit.edu	37	14	22337432	22337432	+	RNA	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:22337432G>A	ENST00000390436.2	+	0	246																											AAATGTGGGCGAAAAGAAAGA	0.428000													61	9					0	0	1	0	0
LETM1	3954	broad.mit.edu	37	4	1817424	1817424	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:1817424C>T	ENST00000302787.2	-	13	2333	c.2037G>A	c.(2035-2037)aaG>aaA	p.K679K		NM_012318.2	NP_036450.1	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane protein 1	679	EF-hand.				cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			CCTTGCCATCCTTGTTTTCAT	0.607000													5	47					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167095812	167095812	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:167095812G>A	ENST00000361200.2	+	6	1610	c.1444G>A	c.(1444-1446)Gag>Aag	p.E482K	DUSP27_ENST00000443333.1_Missense_Mutation_p.E482K|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.E482K			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	482					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CGCATGGAACGAGAGGCTGCT	0.647000													12	19					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17266548	17266548	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:17266548G>A	ENST00000375541.5	+	13	1837	c.1768G>A	c.(1768-1770)Gag>Aag	p.E590K	CROCC_ENST00000467938.1_3'UTR	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	590					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CGCCCAGCGCGAGGTGCAGCG	0.677000													8	20					0	0	1	0	0
CBFA2T3	863	broad.mit.edu	37	16	88968044	88968044	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:88968044T>A	ENST00000268679.4	-	2	568	c.172A>T	c.(172-174)Aag>Tag	p.K58*	CBFA2T3_ENST00000327483.5_5'UTR|CBFA2T3_ENST00000448839.1_Intron|CBFA2T3_ENST00000436887.2_Nonsense_Mutation_p.K58*|CBFA2T3_ENST00000360302.2_5'UTR	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	58	Mediates interaction with PDE7A (in isoform 2).|Mediates localization to the nucleus (By similarity).|Pro-rich.|Required for nucleolar targeting (in isoform 1).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		GCTGAGGCCTTAGCTTTCCTG	0.682000			T	RUNX1	AML								26	18					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13839596	13839596	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:13839596C>T	ENST00000265104.4	-	35	5855	c.5751G>A	c.(5749-5751)ctG>ctA	p.L1917L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1917	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGCACTGTTTCAGCCACTCAA	0.373000									Kartagener syndrome				12	22					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9049492	9049492	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:9049492G>A	ENST00000397910.4	-	5	32342	c.32139C>T	c.(32137-32139)gcC>gcT	p.A10713A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10715	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGGACTGGTGGCTATTGAAG	0.488000													74	92					0	0	1	0	0
AGPAT9	84803	broad.mit.edu	37	4	84502744	84502744	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:84502744G>A	ENST00000395226.2	+	4	456	c.238G>A	c.(238-240)Gaa>Aaa	p.E80K	AGPAT9_ENST00000264409.4_Missense_Mutation_p.E80K	NM_001256421.1	NP_001243350.1	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	80					phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(3)	13		Hepatocellular(203;0.114)				GTCACCCATGGAAAAAGGGCT	0.423000													29	40					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123847920	123847920	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:123847920C>T	ENST00000531945.1	-	1	568	c.479G>A	c.(478-480)gGa>gAa	p.G160E		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	160					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCAGGTGATTCCAGCCATTTC	0.557000													10	8					0	0	1	0	0
VSTM4	196740	broad.mit.edu	37	10	50227709	50227709	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:50227709C>T	ENST00000332853.3	-	8	972	c.949G>A	c.(949-951)Gag>Aag	p.E317K		NM_001031746.3	NP_001026916.2	Q8IW00	CJ072_HUMAN	V-set and transmembrane domain containing 4	317						integral to membrane|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|skin(2)	31						AGCTTGTTCTCCTCGAAGAGG	0.512000													24	7					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150773146	150773146	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:150773146G>A	ENST00000370357.4	+	3	302	c.57G>A	c.(55-57)agG>agA	p.R19R		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	19						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCTCAAAGGAAATTAAACT	0.333000													9	10					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3127320	3127320	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:3127320G>A	ENST00000355072.5	+	11	1511	c.1366G>A	c.(1366-1368)Gaa>Aaa	p.E456K		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	456					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GGATGACTCTGAATCGAGATC	0.453000													26	16					0	0	1	0	0
HFM1	164045	broad.mit.edu	37	1	91850744	91850744	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:91850744G>A	ENST00000370425.3	-	6	900	c.802_splice	c.e6+1	p.P268_splice	HFM1_ENST00000370424.3_Intron|HFM1_ENST00000294696.5_5'UTR	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	268							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TAAAGGATACGAATTTCTGTG	0.249000													6	29					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198950720	198950720	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:198950720C>T	ENST00000428675.1	+	2	2877	c.2479C>T	c.(2479-2481)Ccc>Tcc	p.P827S	PLCL1_ENST00000437704.2_Missense_Mutation_p.P729S	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	827					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	TCGGCATGTTCCCCTGCGTTC	0.453000													25	26					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2706446	2706446	+	Silent	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:2706446T>C	ENST00000399655.1	+	21	3109	c.2844T>C	c.(2842-2844)atT>atC	p.I948I	CACNA1C_ENST00000399641.1_Intron|CACNA1C_ENST00000344100.3_Silent_p.I948I|CACNA1C_ENST00000399629.1_Intron|CACNA1C_ENST00000335762.5_Silent_p.I973I|CACNA1C_ENST00000399595.1_Silent_p.I948I|CACNA1C_ENST00000399637.1_Intron|CACNA1C_ENST00000399621.1_Silent_p.I948I|CACNA1C_ENST00000399591.1_Intron|CACNA1C_ENST00000399634.1_Silent_p.I948I|CACNA1C_ENST00000399606.1_Silent_p.I948I|CACNA1C_ENST00000399597.1_Silent_p.I948I|CACNA1C_ENST00000399638.1_Silent_p.I948I|CACNA1C_ENST00000399617.1_Silent_p.I948I|CACNA1C_ENST00000399603.1_Silent_p.I948I|CACNA1C_ENST00000347598.4_Silent_p.I948I|CACNA1C_ENST00000327702.7_Intron|CACNA1C_ENST00000402845.3_Silent_p.I948I|CACNA1C_ENST00000480911.1_Intron|CACNA1C_ENST00000399601.1_Intron|CACNA1C_ENST00000399649.1_Silent_p.I948I|CACNA1C_ENST00000406454.3_Silent_p.I948I|CACNA1C_ENST00000399644.1_Intron	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	948					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CCATTGAAATTGCTCTGAAGG	0.483000													64	79					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56086983	56086983	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:56086983C>T	ENST00000257880.7	-	21	3005	c.2786G>A	c.(2785-2787)gGc>gAc	p.G929D	ITGA7_ENST00000555728.1_Missense_Mutation_p.G929D|ITGA7_ENST00000553804.1_Missense_Mutation_p.G889D|ITGA7_ENST00000257879.6_Missense_Mutation_p.G885D|ITGA7_ENST00000347027.6_Missense_Mutation_p.G879D|ITGA7_ENST00000394230.2_Missense_Mutation_p.G889D|ITGA7_ENST00000394229.2_Missense_Mutation_p.G885D|ITGA7_ENST00000452168.2_Missense_Mutation_p.G792D			Q13683	ITA7_HUMAN	integrin, alpha 7	929					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CCCCTGCCCGCCCTCCAGCTC	0.597000													42	52					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182359477	182359477	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:182359477C>T	ENST00000397033.2	+	12	1707	c.1277C>T	c.(1276-1278)tCg>tTg	p.S426L		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	426					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ATCAGCAAATCGTTAAGTATG	0.308000													33	41					0	0	1	0	0
OR2F1	26211	broad.mit.edu	37	7	143657556	143657556	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:143657556C>T	ENST00000392899.1	+	1	530	c.493C>T	c.(493-495)Cag>Tag	p.Q165*		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					TATCACCTTTCAGCTGCCCAT	0.522000													27	40					0	0	1	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1816055	1816055	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:1816055C>T	ENST00000250894.4	+	21	2695	c.2538C>T	c.(2536-2538)atC>atT	p.I846I	MAPK8IP3_ENST00000356010.5_Silent_p.I840I	NM_015133.3	NP_055948.2	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting protein 3	846					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	42						TGGCCGGTATCACCCTGGTGG	0.692000													23	28					0	0	1	0	0
OAS1	4938	broad.mit.edu	37	12	113346531	113346531	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:113346531C>T	ENST00000452357.2	+	2	561	c.371C>T	c.(370-372)cCa>cTa	p.P124L	OAS1_ENST00000445409.2_Missense_Mutation_p.P124L|RP1-71H24.1_ENST00000552784.1_RNA|OAS1_ENST00000553185.1_Missense_Mutation_p.P124L|OAS1_ENST00000202917.5_Missense_Mutation_p.P124L|OAS1_ENST00000551241.1_Missense_Mutation_p.P124L	NM_002534.2	NP_002525.2	P00973	OAS1_HUMAN	2'-5'-oligoadenylate synthetase 1, 40/46kDa	124	Necessary for binding to dsRNA.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)|skin(1)	16						GTCCAGGCTCCACGCTGGGGC	0.577000													32	4					0	0	1	0	0
CCNDBP1	23582	broad.mit.edu	37	15	43477730	43477730	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:43477730C>T	ENST00000300213.4	+	1	276	c.34C>T	c.(34-36)Ccc>Tcc	p.P12S	EPB42_ENST00000563128.1_Intron|CCNDBP1_ENST00000356633.5_5'UTR	NM_012142.4	NP_036274.3	O95273	CCDB1_HUMAN	cyclin D-type binding-protein 1	12	Interaction with RPLP0.|Interaction with TCF3.|Required for interaction with CCND1.				cell cycle	cytoplasm|nucleus	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)	13		all_cancers(109;3.31e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.42e-07)		AGCCGCAGTCCCCACCCTGGC	0.677000													4	3					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23703324	23703324	+	Missense_Mutation	SNP	G	G	A	rs139320105		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:23703324G>A	ENST00000256797.4	-	19	2648	c.2480C>T	c.(2479-2481)cCc>cTc	p.P827L	ERN2_ENST00000457008.2_Missense_Mutation_p.P727L	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	779	KEN.				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CCAAAAGAAGGGGTGGGCCAG	0.592000													144	141					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34118052	34118052	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:34118052C>T	ENST00000373381.4	-	28	4633	c.4457G>A	c.(4456-4458)gGg>gAg	p.G1486E	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Missense_Mutation_p.G359E	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1446	CUB 9.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CAGGTCTCCCCCGCAGGGAGC	0.557000													41	11					0	0	1	0	0
IST1	9798	broad.mit.edu	37	16	71957234	71957234	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:71957234C>T	ENST00000378799.6	+	8	1159	c.803C>T	c.(802-804)cCc>cTc	p.P268L	RP11-498D10.5_ENST00000567146.1_RNA|IST1_ENST00000541571.2_Missense_Mutation_p.P268L|IST1_ENST00000544564.1_Missense_Mutation_p.P268L|IST1_ENST00000329908.8_Missense_Mutation_p.P268L|IST1_ENST00000606369.1_Missense_Mutation_p.P120L|IST1_ENST00000538565.1_3'UTR|IST1_ENST00000535424.1_Missense_Mutation_p.P281L|IST1_ENST00000538850.1_Missense_Mutation_p.P120L|IST1_ENST00000378798.5_Intron	NM_001270975.1	NP_001257904.1	P53990	IST1_HUMAN	increased sodium tolerance 1 homolog (yeast)	266	Interaction with VPS37B.|Interaction with VTA1.				cell cycle|cell division	cytoplasmic membrane-bounded vesicle|ER-Golgi intermediate compartment	protein binding										CAGGCCTTTCCCAATATTCAT	0.468000													18	31					0	0	1	0	0
OR1A1	8383	broad.mit.edu	37	17	3119201	3119201	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:3119201G>A	ENST00000304094.1	+	1	287	c.287G>A	c.(286-288)gGa>gAa	p.G96E		NM_014565.2	NP_055380.2	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A, member 1	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	23						TCTTTTGGGGGATGCCTAACG	0.493000													16	45					0	0	1	0	0
C1QB	713	broad.mit.edu	37	1	22987402	22987402	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:22987402G>A	ENST00000509305.1	+	3	625	c.279G>A	c.(277-279)atG>atA	p.M93I	C1QB_ENST00000314933.6_Missense_Mutation_p.M95I			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	95	Collagen-like 2.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGGGCCCCATGGGCCCTAAAG	0.622000													17	62					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43895734	43895734	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:43895734C>T	ENST00000562955.1	+	29	4190	c.4190C>T	c.(4189-4191)cCc>cTc	p.P1397L	SZT2_ENST00000372442.1_Missense_Mutation_p.P555L	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1454						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CCTTCCAATCCCCACTACTTC	0.542000													44	35					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94120377	94120377	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:94120377G>A	ENST00000369303.4	-	3	858	c.674C>T	c.(673-675)tCc>tTc	p.S225F	EPHA7_ENST00000369297.1_Missense_Mutation_p.S225F	NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	225	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GACTAAAGAGGAAAATTCTGA	0.463000													11	7					0	0	1	0	0
GIPC3	126326	broad.mit.edu	37	19	3589508	3589508	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:3589508G>A	ENST00000322315.5	+	4	705	c.660G>A	c.(658-660)gaG>gaA	p.E220E		NM_133261.2	NP_573568.1	Q8TF64	GIPC3_HUMAN	GIPC PDZ domain containing family, member 3	220										breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGGAGGGAGACCCTGCGGC	0.612000													26	30					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77406717	77406717	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:77406717G>A	ENST00000560626.2	-	7	5497	c.5022C>T	c.(5020-5022)ctC>ctT	p.L1674L	PEAK1_ENST00000312493.4_Silent_p.L1674L			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1674	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										AAGTCTGGAAGAGATCTTCGC	0.557000													21	54					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34018860	34018860	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr21:34018860G>A	ENST00000382499.2	-	24	3206	c.3207C>T	c.(3205-3207)ctC>ctT	p.L1069L	SYNJ1_ENST00000382491.3_Silent_p.L1025L|SYNJ1_ENST00000322229.7_Silent_p.L1030L|SYNJ1_ENST00000357345.3_Silent_p.L1030L|SYNJ1_ENST00000433931.2_Silent_p.L1069L	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	1030	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						AAGATGGCTGGAGATGCTGAG	0.493000													32	20					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51266974	51266974	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:51266974C>T	ENST00000266037.9	+	19	1874	c.1851C>T	c.(1849-1851)gcC>gcT	p.A617A		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	617	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		AGTGGAAAGCCTTCCCCGACC	0.448000													5	20					0	0	1	0	0
NOP14	8602	broad.mit.edu	37	4	2943384	2943384	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:2943384G>A	ENST00000416614.2	-	15	2189	c.2124C>T	c.(2122-2124)ttC>ttT	p.F708F	NOP14-AS1_ENST00000503709.1_RNA|NOP14-AS1_ENST00000515194.1_RNA|NOP14-AS1_ENST00000507702.1_RNA|NOP14_ENST00000507120.1_5'UTR|NOP14-AS1_ENST00000512712.2_RNA|NOP14-AS1_ENST00000505731.1_RNA|NOP14_ENST00000314262.6_Silent_p.F708F|NOP14_ENST00000502735.1_Silent_p.F708F|NOP14_ENST00000398071.4_Silent_p.F708F			P78316	NOP14_HUMAN	NOP14 nucleolar protein	708					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	30						TGATGGCGTGGAAGGATGGCA	0.667000													7	22					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2321222	2321222	+	Missense_Mutation	SNP	G	G	A	rs149044769		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr20:2321222G>A	ENST00000381458.5	+	13	2140	c.2077G>A	c.(2077-2079)Gaa>Aaa	p.E693K		NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	693					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	CGATGTAGCCGAATGAAGGGC	0.592000													29	42					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17637499	17637499	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:17637499G>A	ENST00000262077.2	-	16	2348	c.2349C>T	c.(2347-2349)acC>acT	p.T783T	NUP153_ENST00000537253.1_Silent_p.T814T	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	783					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			CAAATCCTAAGGTACCAGTGG	0.438000													13	81					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25565092	25565092	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:25565092G>A	ENST00000269141.3	-	13	2504	c.2081C>T	c.(2080-2082)tCc>tTc	p.S694F	CDH2_ENST00000399380.3_Missense_Mutation_p.S663F	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	694	Cadherin 5.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						ACGCAGGATGGAAATATTTGA	0.463000													10	16					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5226977	5226977	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:5226977G>A	ENST00000334314.3	-	1	167	c.91C>T	c.(91-93)Cat>Tat	p.H31Y	AKR1CL1_ENST00000445191.1_Missense_Mutation_p.H27Y					aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						CCACTTACATGATCAGGAGCA	0.517000													13	0					0	0	1	0	0
PROM2	150696	broad.mit.edu	37	2	95947008	95947008	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:95947008C>T	ENST00000317620.9	+	12	1579	c.1446C>T	c.(1444-1446)ttC>ttT	p.F482F	PROM2_ENST00000403131.2_Silent_p.F482F|PROM2_ENST00000317668.4_Silent_p.F482F|PROM2_ENST00000542147.1_Silent_p.F482F	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	482						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						GCCTCAGCTTCCTCTTTGCTG	0.647000													48	39					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143098521	143098521	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:143098521G>A	ENST00000275815.3	-	3	414	c.328C>T	c.(328-330)Cct>Tct	p.P110S		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	110						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				GCTCCCCCAGGGAAACTCTTG	0.617000													137	108					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117632270	117632270	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:117632270G>A	ENST00000368508.3	-	39	6344	c.6146C>T	c.(6145-6147)cCt>cTt	p.P2049L	ROS1_ENST00000368507.3_Missense_Mutation_p.P2043L	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	2049	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GGTGAGTAAAGGACCATAAAA	0.333000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								8	10					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80419517	80419517	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:80419517G>A	ENST00000265080.4	+	16	2594	c.2527G>A	c.(2527-2529)Gac>Aac	p.D843N		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	843					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CCCTGCAGCGGACACCACAGA	0.527000													22	18					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62045702	62045702	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:62045702G>A	ENST00000435607.1	-	6	793	c.717C>T	c.(715-717)atC>atT	p.I239I	SCN4A_ENST00000578147.1_Silent_p.I239I	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	239					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GGGCCCCCACGATCGTCTTCA	0.602000													29	40					0	0	1	0	0
UGT1A6	54578	broad.mit.edu	37	2	234601756	234601756	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:234601756G>A	ENST00000305139.6	+	1	245	c.106G>A	c.(106-108)Gga>Aga	p.G36R	UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A10_ENST00000344644.5_Intron	NM_001072.3	NP_001063.2														central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		CCCTCAGGACGGAAGCCACTG	0.483000													34	31					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70924532	70924532	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:70924532C>T	ENST00000603540.1	+	2	574	c.316C>T	c.(316-318)Cca>Tca	p.P106S	ADAM21_ENST00000267499.3_Missense_Mutation_p.P106S|RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	106					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCTCTTCATCCCAGATGACTG	0.478000													28	26					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147889180	147889180	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:147889180G>A	ENST00000360693.3	-	6	1053	c.915C>T	c.(913-915)tcC>tcT	p.S305S	HTR4_ENST00000314512.6_Silent_p.S305S|HTR4_ENST00000517929.1_Silent_p.S305S|HTR4_ENST00000520514.1_Silent_p.S305S|HTR4_ENST00000521735.1_Silent_p.S305S|HTR4_ENST00000362016.2_Silent_p.S319S|HTR4_ENST00000377888.3_Silent_p.S305S|HTR4_ENST00000521530.1_Silent_p.S305S|HTR4_ENST00000354217.2_Silent_p.S305S	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	305					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	GGTTCAACCCGGAATTGATAT	0.488000													16	0					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39162078	39162078	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:39162078G>A	ENST00000359534.3	-	4	839	c.501C>T	c.(499-501)atC>atT	p.I167I		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	167					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						CGCCCCACACGATGAAGATGA	0.557000													16	59					0	0	1	0	0
AP3D1	8943	broad.mit.edu	37	19	2111297	2111297	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:2111297G>A	ENST00000355272.6	-	26	3178	c.2972C>T	c.(2971-2973)tCc>tTc	p.S991F	AP3D1_ENST00000350812.6_Missense_Mutation_p.S760F|AP3D1_ENST00000356926.4_Missense_Mutation_p.S888F|AP3D1_ENST00000345016.5_Missense_Mutation_p.S929F	NM_001261826.1	NP_001248755.1	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1 subunit	929					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTTAACATAGGAATTTTCAGC	0.612000													14	29					0	0	1	0	0
CERS3	204219	broad.mit.edu	37	15	101024834	101024834	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:101024834C>T	ENST00000284382.4	-	6	751	c.328G>A	c.(328-330)Gag>Aag	p.E110K	CERS3_ENST00000394113.1_Missense_Mutation_p.E110K|CERS3_ENST00000538112.2_Missense_Mutation_p.E110K|CERS3_ENST00000560944.1_Intron	NM_178842.3	NP_849164.2	Q8IU89	CERS3_HUMAN	ceramide synthase 3	110						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity	p.E110*(1)									ACCTGGCGCTCCGTCAAGTTA	0.483000													11	8					0	0	1	0	0
STPG2	285555	broad.mit.edu	37	4	98633937	98633937	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:98633937C>T	ENST00000295268.3	-	10	1322	c.1233G>A	c.(1231-1233)agG>agA	p.R411R	STPG2_ENST00000506482.1_5'UTR	NM_174952.2	NP_777612.1			sperm-tail PG-rich repeat containing 2																		GGCAAGATTTCCTTAAAACAG	0.338000													16	13					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25419986	25419986	+	RNA	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:25419986C>T	ENST00000549301.1	+	0	721				SNHG14_ENST00000441592.2_RNA																							tccctgacttccctcaacaCT	0.517000													44	43					0	0	1	0	0
KIF5C	3800	broad.mit.edu	37	2	149806890	149806890	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:149806890G>A	ENST00000435030.1	+	10	1250	c.882G>A	c.(880-882)ggG>ggA	p.G294G	KIF5C_ENST00000397413.1_Silent_p.G62G|KIF5C_ENST00000414838.2_Silent_p.G199G|KIF5C_ENST00000464066.1_3'UTR			O60282	KIF5C_HUMAN	kinesin family member 5C	294	Kinesin-motor.|Microtubule-binding.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		CTTTGGGTGGGAACTGCAGAA	0.473000													22	20					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62611258	62611258	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:62611258G>A	ENST00000281156.4	-	5	780	c.502C>T	c.(502-504)Cgt>Tgt	p.R168C		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		TGTTCCTGACGAATTTCATCA	0.403000													9	13					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43770786	43770786	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:43770786G>A	ENST00000372476.3	+	2	402	c.323G>A	c.(322-324)gGt>gAt	p.G108D	TIE1_ENST00000538015.1_Missense_Mutation_p.G108D|TIE1_ENST00000441333.2_Missense_Mutation_p.G108D	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	108					mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGCGTGGGCGGTGCTGGGGCG	0.711000													26	12					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12919788	12919788	+	Silent	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:12919788T>C	ENST00000240189.2	+	3	615	c.528T>C	c.(526-528)ggT>ggC	p.G176G		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	176										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAAGGAGAGGTTTAGTACACC	0.408000													37	169					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97984035	97984035	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:97984035C>T	ENST00000383696.2	+	1	948	c.907C>T	c.(907-909)Ccc>Tcc	p.P303S	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TTTATTAAATCCCATGATCTA	0.383000													15	14					0	0	1	0	0
LIN7A	8825	broad.mit.edu	37	12	81242078	81242078	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:81242078C>T	ENST00000552864.1	-	3	427	c.225G>A	c.(223-225)acG>acA	p.T75T		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	75	L27.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						TAACAGTTATCGTTTCATGCA	0.323000													12	6					0	0	1	0	0
MDFIC	29969	broad.mit.edu	37	7	114619811	114619811	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:114619811C>T	ENST00000257724.3	+	4	1058	c.795C>T	c.(793-795)tcC>tcT	p.S265S	MDFIC_ENST00000393486.1_Silent_p.S156S			Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing	156					activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleolus|nucleus	cyclin binding|Tat protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	8						CTGTCTTTTCCCAAAAGACAG	0.338000													21	21					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													4	24					0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	418967	418967	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:418967G>A	ENST00000332826.6	-	21	2041	c.1957C>T	c.(1957-1959)Cac>Tac	p.H653Y		NM_001012302.2	NP_001012302.2	A1A5B4	ANO9_HUMAN	anoctamin 9	653						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						GACAGGCTGTGGTTGACGTAG	0.622000													34	42					0	0	1	0	0
RPE65	6121	broad.mit.edu	37	1	68897194	68897194	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:68897194G>A	ENST00000262340.5	-	11	1256	c.1203C>T	c.(1201-1203)atC>atT	p.I401I		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	401					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						GCTCCAGCCAGATAGTCTCGT	0.458000													22	8					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16021677	16021677	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:16021677C>T	ENST00000350896.3	-	5	911	c.714G>A	c.(712-714)caG>caA	p.Q238Q	MSR1_ENST00000262101.5_Silent_p.Q238Q|MSR1_ENST00000445506.2_Silent_p.Q256Q|MSR1_ENST00000536385.1_Silent_p.Q12Q|MSR1_ENST00000355282.2_Silent_p.Q238Q|MSR1_ENST00000381998.4_Silent_p.Q238Q	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	238					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CTTTTATTTCCTGTTCCAAAT	0.338000													4	19					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201507384	201507384	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:201507384C>T	ENST00000374700.2	+	25	2948	c.2707C>T	c.(2707-2709)Ctc>Ttc	p.L903F	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	903					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GTTTCCCAATCTCCGCTGCCG	0.468000													20	16					0	0	1	0	0
C7orf62	219557	broad.mit.edu	37	7	88424217	88424217	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:88424217G>A	ENST00000297203.2	-	2	225	c.40C>T	c.(40-42)Cct>Tct	p.P14S	ZNF804B_ENST00000333190.4_Intron	NM_152706.3	NP_689919.1	Q8TBZ9	CG062_HUMAN	chromosome 7 open reading frame 62	14										NS(1)|breast(1)|endometrium(3)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	30						AGTGGCAAAGGCCTTTTGCTG	0.398000													51	39					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55638936	55638936	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:55638936C>T	ENST00000370830.3	-	4	1636	c.938G>A	c.(937-939)cGa>cAa	p.R313Q	BMP5_ENST00000446683.2_Missense_Mutation_p.R313Q	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	313					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			TCTCACGGATCGAAGAAGTAC	0.453000													21	20					0	0	1	0	0
CLVS2	134829	broad.mit.edu	37	6	123332192	123332192	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:123332192C>T	ENST00000275162.4	+	3	1787	c.452C>T	c.(451-453)cCt>cTt	p.P151L	CLVS2_ENST00000368438.1_Missense_Mutation_p.P5L	NM_001010852.2	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2	151	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						ATTGAAGATCCTGAGCTTCAA	0.403000													19	30					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26423512	26423512	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:26423512C>T	ENST00000335473.7	+	43	7822	c.7572C>T	c.(7570-7572)atC>atT	p.I2524I	MYO18B_ENST00000407587.2_Silent_p.I2525I|MYO18B_ENST00000536101.1_Silent_p.I2524I	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2524						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CTGACAGCATCAAAAGTCGAC	0.597000													13	20					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124283832	124283832	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:124283832G>A	ENST00000409039.3	+	13	1874	c.1849G>A	c.(1849-1851)Gag>Aag	p.E617K		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	617	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GACAATGAAGGAGTATGAAGA	0.443000													14	4					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146471445	146471445	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:146471445C>T	ENST00000361727.3	+	2	696	c.180C>T	c.(178-180)ccC>ccT	p.P60P		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	60	F5/8 type C.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GCTATTCTCCCGGCTATGCCA	0.383000										HNSCC(39;0.1)			28	11					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179495665	179495665	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:179495665C>T	ENST00000589042.1	-	238	44244	c.44020G>A	c.(44020-44022)Gaa>Aaa	p.E14674K	TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E5609K|TTN_ENST00000359218.5_Missense_Mutation_p.E5734K|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E5801K|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E13033K|TTN_ENST00000342992.6_Missense_Mutation_p.E12106K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13033	Ig-like 96.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTTAATTTCCCGATCTAGA	0.478000													12	27					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51165484	51165484	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:51165484G>A	ENST00000293441.1	-	23	6242	c.6224C>T	c.(6223-6225)tCc>tTc	p.S2075F	SYT3_ENST00000544769.1_Intron|SHANK1_ENST00000391813.1_Missense_Mutation_p.S1462F|SHANK1_ENST00000391814.1_Missense_Mutation_p.S2083F|SHANK1_ENST00000359082.3_Missense_Mutation_p.S2066F	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2075					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CGGTGAGAGGGAGCGCGAGGC	0.687000													26	7					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143807472	143807472	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:143807472G>A	ENST00000408979.2	+	1	866	c.797G>A	c.(796-798)cGa>cAa	p.R266Q		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R266Q(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					TCTAATCAACGAGAGGAGCAG	0.512000													105	101					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30963131	30963131	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:30963131C>T	ENST00000311813.4	+	4	752	c.697C>T	c.(697-699)Cca>Tca	p.P233S	AQP1_ENST00000409899.1_Missense_Mutation_p.P118S|AQP1_ENST00000434909.2_Missense_Mutation_p.P293S|AQP1_ENST00000441328.2_Missense_Mutation_p.P150S|AQP1_ENST00000409611.1_Missense_Mutation_p.P182S|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000509504.1_Missense_Mutation_p.P410S	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				CATCCTGGCCCCACGCAGCAG	0.592000													22	26					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900742	151900742	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:151900742C>A	ENST00000393900.3	-	3	412	c.59G>T	c.(58-60)gGa>gTa	p.G20V	MAGEA12_ENST00000393869.3_Missense_Mutation_p.G20V|CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000357916.4_Missense_Mutation_p.G20V	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	20										breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					CAGGGCCTCTCCTTGGGCCTC	0.622000													34	42					1.08052e-11	1.09671e-11	1	1	0
C15orf43	145645	broad.mit.edu	37	15	45250611	45250611	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:45250611G>A	ENST00000340827.3	+	3	204	c.187G>A	c.(187-189)Gtt>Att	p.V63I		NM_152448.2	NP_689661.1	Q8NHR7	CO043_HUMAN	chromosome 15 open reading frame 43	63										NS(1)|breast(2)|large_intestine(1)|lung(2)|skin(2)	8		all_cancers(109;3.68e-08)|all_epithelial(112;1.05e-06)|Lung NSC(122;1.42e-05)|all_lung(180;0.000112)|Melanoma(134;0.0192)		all cancers(107;7.64e-17)|GBM - Glioblastoma multiforme(94;2.03e-06)		TAATGCTACAGTTTTTCATGC	0.363000													28	14					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80329277	80329277	+	Silent	SNP	C	C	T	rs145465808		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:80329277C>T	ENST00000358842.3	-	1	95	c.78G>A	c.(76-78)ctG>ctA	p.L26L		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	26					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						AATTGAAAACCAGAAAGCGAG	0.507000													15	28					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4869915	4869915	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:4869915G>A	ENST00000322101.2	-	1	599	c.524C>T	c.(523-525)cCc>cTc	p.P175L	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAGGCAGTAGGGCATGTAGGC	0.542000													36	35					0	0	1	0	0
UBR3	130507	broad.mit.edu	37	2	170857905	170857905	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:170857905C>T	ENST00000272793.5	+	27	4060	c.4010C>T	c.(4009-4011)tCt>tTt	p.S1337F	UBR3_ENST00000418381.1_Missense_Mutation_p.S1337F|UBR3_ENST00000392631.1_Missense_Mutation_p.S158F			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1337					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						TGTCATAAATCTTACATGGAA	0.328000													13	51					0	0	1	0	0
NDRG1	10397	broad.mit.edu	37	8	134256628	134256628	+	Silent	SNP	C	C	T	rs150101908	by1000genomes	TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:134256628C>T	ENST00000414097.2	-	14	1728	c.861G>A	c.(859-861)gcG>gcA	p.A287A	NDRG1_ENST00000521414.1_5'UTR|NDRG1_ENST00000537882.1_Silent_p.A206A|NDRG1_ENST00000354944.5_Silent_p.A217A|NDRG1_ENST00000522476.1_Silent_p.A221A|NDRG1_ENST00000518066.1_Intron|NDRG1_ENST00000323851.7_Silent_p.A287A|NDRG1_ENST00000518176.1_Silent_p.A34A	NM_001135242.1	NP_001128714.1	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	287					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding		NDRG1/ERG(5)	endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(4)|prostate(1)|skin(1)	17	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			CGCCACAGTCCGCCATCTAGG	0.577000			T	ERG	prostate								22	19					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9561520	9561520	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr20:9561520C>T	ENST00000378429.3	-	5	808	c.262G>A	c.(262-264)Gat>Aat	p.D88N	PAK7_ENST00000353224.5_Missense_Mutation_p.D88N|PAK7_ENST00000378423.1_Missense_Mutation_p.D88N	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	88	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			TTGTCAAAATCCTCTAGCAGG	0.493000													53	65					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10431281	10431281	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:10431281C>T	ENST00000377086.1	+	45	5109	c.4907C>T	c.(4906-4908)cCc>cTc	p.P1636L	KIF1B_ENST00000377081.1_Missense_Mutation_p.P1636L|KIF1B_ENST00000263934.6_Missense_Mutation_p.P1590L			O60333	KIF1B_HUMAN	kinesin family member 1B	1636					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TCCACCTGTCCCTCTCTGGTA	0.488000													14	28					0	0	1	0	0
CPNE5	57699	broad.mit.edu	37	6	36730754	36730754	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:36730754C>T	ENST00000244751.2	-	12	1419	c.795G>A	c.(793-795)ggG>ggA	p.G265G		NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	265	C2 2.									central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						TGGTGAACTCCCCAATGAAGT	0.582000													12	103					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52200305	52200305	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:52200305G>A	ENST00000354534.5	+	27	5213	c.5035G>A	c.(5035-5037)Gag>Aag	p.E1679K	SCN8A_ENST00000545061.1_Missense_Mutation_p.E1638K	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1679					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	TGTGAAGCACGAGGCTGGTAT	0.478000													37	40					0	0	1	0	0
KIAA1524	57650	broad.mit.edu	37	3	108270127	108270127	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:108270127G>A	ENST00000295746.8	-	21	2663	c.2587C>T	c.(2587-2589)Cgt>Tgt	p.R863C	KIAA1524_ENST00000491772.1_Missense_Mutation_p.R704C	NM_020890.2	NP_065941.2	Q8TCG1	CIP2A_HUMAN	KIAA1524	863						cytoplasm|integral to membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(21)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TCTTCCAAACGACCTTCTAAT	0.408000													7	21					0	0	1	0	0
ARHGEF3	50650	broad.mit.edu	37	3	56779338	56779338	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:56779338G>A	ENST00000413728.2	-	7	1326	c.783C>T	c.(781-783)ttC>ttT	p.F261F	ARHGEF3_ENST00000497267.1_Silent_p.F226F|ARHGEF3_ENST00000495373.1_Silent_p.F255F|ARHGEF3_ENST00000338458.4_Silent_p.F287F|ARHGEF3_ENST00000496106.1_Silent_p.F261F|ARHGEF3_ENST00000296315.3_Silent_p.F255F	NM_001128616.1	NP_001122088.1	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor (GEF) 3	255	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	25				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)		GAATATCGAGGAAATTCCAGA	0.468000													71	48					0	0	1	0	0
PPOX	5498	broad.mit.edu	37	1	161138347	161138347	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:161138347G>A	ENST00000367999.4	+	6	863	c.597G>A	c.(595-597)ctG>ctA	p.L199L	PPOX_ENST00000352210.5_Silent_p.L199L|PPOX_ENST00000535223.1_Intron|PPOX_ENST00000432542.2_Intron|PPOX_ENST00000544598.1_Intron|PPOX_ENST00000495483.1_3'UTR	NM_001122764.1	NP_001116236.1	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	199					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(3)	15	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CCATATTACTGGGCCTGCTGC	0.537000													22	26					0	0	1	0	0
ARHGAP5	394	broad.mit.edu	37	14	32561666	32561666	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:32561666C>T	ENST00000345122.3	+	2	2106	c.1791C>T	c.(1789-1791)aaC>aaT	p.N597N	ARHGAP5_ENST00000539826.2_Silent_p.N597N|ARHGAP5_ENST00000432921.1_Silent_p.N597N|ARHGAP5_ENST00000556611.1_Silent_p.N597N|ARHGAP5_ENST00000433497.1_Intron|ARHGAP5_ENST00000396582.2_Intron	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	597					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		ATAAAGTTAACCTTTTTATTT	0.368000													16	3					0	0	1	0	0
APOL5	80831	broad.mit.edu	37	22	36122381	36122381	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:36122381C>T	ENST00000249044.2	+	3	266	c.266C>T	c.(265-267)tCc>tTc	p.S89F		NM_030642.1	NP_085145.1	Q9BWW9	APOL5_HUMAN	apolipoprotein L, 5	89					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|skin(2)|urinary_tract(1)	19						GACAAAGATTCCATGCCAGAT	0.393000													11	27					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1081530	1081530	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:1081530G>A	ENST00000441003.2	+	12	1575	c.1548G>A	c.(1546-1548)ctG>ctA	p.L516L	MUC2_ENST00000359061.5_Silent_p.L516L	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	516	VWFD 2.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TTGTGACACTGGACCAGGCCT	0.642000													8	10					0	0	1	0	0
STT3B	201595	broad.mit.edu	37	3	31661282	31661282	+	Silent	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:31661282T>C	ENST00000295770.2	+	9	1496	c.1287T>C	c.(1285-1287)ctT>ctC	p.L429L	STT3B_ENST00000453168.1_3'UTR	NM_178862.1	NP_849193.1	Q8TCJ2	STT3B_HUMAN	STT3B, subunit of the oligosaccharyltransferase complex (catalytic)	429					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			autonomic_ganglia(1)|biliary_tract(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	19						CAGCAGGCCTTTGGTTCTGCA	0.343000													6	23					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126882873	126882873	+	Missense_Mutation	SNP	G	G	A	rs143468706		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:126882873G>A	ENST00000339582.2	-	2	1194	c.386C>T	c.(385-387)tCg>tTg	p.S129L	GRM8_ENST00000444921.2_Missense_Mutation_p.S129L|GRM8_ENST00000405249.1_Missense_Mutation_p.S129L|GRM8_ENST00000358373.3_Missense_Mutation_p.S129L			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	129					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane		p.S129L(1)		breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CTTCACATCCGAAGCATCTTT	0.502000										HNSCC(24;0.065)			47	29					0	0	1	0	0
CD1B	910	broad.mit.edu	37	1	158299203	158299203	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:158299203C>T	ENST00000368168.3	-	4	950	c.843G>A	c.(841-843)gtG>gtA	p.V281V		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	281	Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					TGCTGTGCTTCACCCGACAGG	0.557000													29	34					0	0	1	0	0
C17orf80	55028	broad.mit.edu	37	17	71232516	71232516	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:71232516G>A	ENST00000359042.2	+	3	1089	c.895G>A	c.(895-897)Gga>Aga	p.G299R	C17orf80_ENST00000582793.1_Intron|FAM104A_ENST00000583178.1_Intron|C17orf80_ENST00000268942.8_Missense_Mutation_p.G299R|C17orf80_ENST00000535032.2_Missense_Mutation_p.G299R|C17orf80_ENST00000255557.4_Missense_Mutation_p.G299R|C17orf80_ENST00000426147.2_Missense_Mutation_p.G299R|C17orf80_ENST00000577615.1_Missense_Mutation_p.G299R	NM_017941.4	NP_060411.2	Q9BSJ5	CQ080_HUMAN	chromosome 17 open reading frame 80	299						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			ACAAGAGAAAGGACTTACCCT	0.433000													9	13					0	0	1	0	0
OR4B1	119765	broad.mit.edu	37	11	48239033	48239033	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:48239033G>A	ENST00000309562.2	+	1	690	c.672G>A	c.(670-672)agG>agA	p.R224R		NM_001005470.1	NP_001005470.1	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B, member 1	224					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						TCAACTTGAGGAACCATTCTG	0.473000													6	11					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50776748	50776748	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr20:50776748G>A	ENST00000216923.4	-	5	1026	c.677C>T	c.(676-678)tCg>tTg	p.S226L	ZFP64_ENST00000371518.2_Missense_Mutation_p.S226L|ZFP64_ENST00000361387.2_Missense_Mutation_p.S226L|ZFP64_ENST00000371515.4_Missense_Mutation_p.S224L|ZFP64_ENST00000477786.1_5'UTR|ZFP64_ENST00000346617.4_Missense_Mutation_p.S172L	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						CCGCTCGTCCGAGTGGATCCT	0.627000													62	75					0	0	1	0	0
AADACL2	344752	broad.mit.edu	37	3	151474795	151474795	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:151474795G>A	ENST00000356517.3	+	5	728	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	RP11-454C18.2_ENST00000475855.1_RNA|RP11-454C18.2_ENST00000483843.2_RNA	NM_207365.3	NP_997248.2	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2	207						extracellular region|integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(13)|skin(2)	24			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			GAATGATGCTGAAATAAAACA	0.318000													18	11					0	0	1	0	0
GBP2	2634	broad.mit.edu	37	1	89579925	89579925	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:89579925G>A	ENST00000370466.3	-	7	1191	c.923C>T	c.(922-924)cCc>cTc	p.P308L	GBP2_ENST00000463660.1_5'UTR	NM_004120.3	NP_004111.2	P32456	GBP2_HUMAN	guanylate binding protein 2, interferon-inducible	308					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(1)	20		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		CTCCATGCAGGGTAGATCCCC	0.512000													14	39					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56352921	56352921	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:56352921G>A	ENST00000340482.3	-	7	1619	c.1443C>T	c.(1441-1443)atC>atT	p.I481I	MPO_ENST00000225275.3_Silent_p.I449I			P05164	PERM_HUMAN	myeloperoxidase	449					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	TGGCCCCCACGATCTTCCGGG	0.602000													9	25					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50099959	50099959	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:50099959C>G	ENST00000418929.2	+	4	2379	c.2367C>G	c.(2365-2367)gaC>gaG	p.D789E		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	481							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GGGGCCCTGACCTCCCACTGG	0.711000													14	13					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9060392	9060392	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:9060392C>T	ENST00000397910.4	-	3	27257	c.27054G>A	c.(27052-27054)aaG>aaA	p.K9018K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9020	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGTGCTTGGCTTTGTGGCTG	0.527000													24	35					0	0	1	0	0
LIPM	340654	broad.mit.edu	37	10	90572917	90572917	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:90572917A>G	ENST00000539337.1	+	4	464	c.209A>G	c.(208-210)aAc>aGc	p.N70S	LIPM_ENST00000404743.4_Missense_Mutation_p.N110S			Q5VYY2	LIPM_HUMAN	lipase, family member M	110					lipid catabolic process	extracellular region	hydrolase activity			breast(1)|central_nervous_system(1)|endometrium(1)|lung(2)|pancreas(1)|skin(1)	7						TGGATTTCCAACCTGCCCAAC	0.493000													11	1					0	0	1	0	0
FSCN3	29999	broad.mit.edu	37	7	127239494	127239494	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:127239494C>T	ENST00000265825.5	+	5	1399	c.1180C>T	c.(1180-1182)Cgt>Tgt	p.R394C	FSCN3_ENST00000420086.2_Missense_Mutation_p.R260C	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	394						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						ATTGCGAGGTCGTTATGGCTA	0.507000													37	59					0	0	1	0	0
TPTEP1	387590	broad.mit.edu	37	22	17119529	17119529	+	RNA	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:17119529C>T	ENST00000426585.1	+	0	341																											ACCTAATTTTCACTGACAGCA	0.333000													23	15					0	0	1	0	0
PAK4	10298	broad.mit.edu	37	19	39660384	39660384	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:39660384C>T	ENST00000599386.1	+	3	372	c.191C>T	c.(190-192)cCc>cTc	p.P64L	PAK4_ENST00000599470.1_Missense_Mutation_p.P64L|PAK4_ENST00000435673.2_Missense_Mutation_p.P64L|PAK4_ENST00000321944.4_Missense_Mutation_p.P64L|PAK4_ENST00000358301.3_Missense_Mutation_p.P64L|PAK4_ENST00000593690.1_Missense_Mutation_p.P64L|PAK4_ENST00000360442.3_Missense_Mutation_p.P64L	NM_001014835.1	NP_001014835.1	O96013	PAK4_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 4	64	Linker.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	13	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			TCCATCCAGCCCGGGGCCCCC	0.711000													16	18					0	0	1	0	0
PER3	8863	broad.mit.edu	37	1	7887695	7887695	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:7887695C>T	ENST00000377532.3	+	17	2930	c.2706C>T	c.(2704-2706)ccC>ccT	p.P902P	PER3_ENST00000361923.2_Silent_p.P894P			P56645	PER3_HUMAN	period circadian clock 3	894					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TGGACCCACCCCCTTCAGTCA	0.547000													66	22					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1457568	1457568	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:1457568C>T	ENST00000345913.4	+	6	676	c.585C>T	c.(583-585)ttC>ttT	p.F195F	TPO_ENST00000382198.1_Silent_p.F195F|TPO_ENST00000382201.3_Silent_p.F195F|TPO_ENST00000346956.3_Silent_p.F195F|TPO_ENST00000337415.3_Silent_p.F195F|TPO_ENST00000329066.4_Silent_p.F195F|TPO_ENST00000497517.2_Intron|TPO_ENST00000349624.3_Silent_p.F195F	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	195					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	ACCCCGGCTTCTTGTACAACG	0.602000													20	15					0	0	1	0	0
CCNF	899	broad.mit.edu	37	16	2483003	2483003	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:2483003T>G	ENST00000397066.4	+	3	301	c.213T>G	c.(211-213)agT>agG	p.S71R		NM_001761.2	NP_001752.2	P41002	CCNF_HUMAN	cyclin F	71	F-box.				cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(2)|lung(5)|prostate(4)|skin(1)	20		Ovarian(90;0.17)				ACCACGCCAGTGTGTGGGCAT	0.602000													4	10					0	0	1	0	0
CAPN2	824	broad.mit.edu	37	1	223940530	223940530	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:223940530C>T	ENST00000295006.5	+	9	1316	c.1007C>T	c.(1006-1008)tCc>tTc	p.S336F	CAPN2_ENST00000433674.2_Missense_Mutation_p.S258F	NM_001748.4	NP_001739.2	P17655	CAN2_HUMAN	calpain 2, (m/II) large subunit	336	Calpain catalytic.				proteolysis	cytoplasm|plasma membrane				breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|stomach(3)	29				GBM - Glioblastoma multiforme(131;0.109)		AGGCACTATTCCCGCCTGGAG	0.507000													16	24					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44932917	44932917	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:44932917C>T	ENST00000291187.4	-	6	2343	c.2021G>A	c.(2020-2022)gGa>gAa	p.G674E	ZNF229_ENST00000591289.1_Intron|ZNF229_ENST00000588931.1_Missense_Mutation_p.G680E|CTC-512J12.4_ENST00000588655.1_RNA	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	680					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GGGCTTTTTTCCCGTGTGGAC	0.507000													20	52					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87693930	87693930	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:87693930G>A	ENST00000436978.1	+	32	5663		c.e32-1		PTPN13_ENST00000511467.1_Splice_Site|PTPN13_ENST00000316707.6_Splice_Site|PTPN13_ENST00000411767.2_Splice_Site|PTPN13_ENST00000427191.2_Splice_Site	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)							cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TGTCTCTGTAGTAATCCTTCC	0.373000													14	60					0	0	1	0	0
FAM19A2	338811	broad.mit.edu	37	12	62261172	62261172	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:62261172C>T	ENST00000416284.3	-	2	1619	c.35G>A	c.(34-36)gGa>gAa	p.G12E	FAM19A2_ENST00000551619.1_Missense_Mutation_p.G12E|FAM19A2_ENST00000551449.1_Missense_Mutation_p.G12E	NM_178539.4	NP_848634.1	Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A2	12						cytoplasm		p.G12E(1)		endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	15			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		TAGCAGTTTTCCTTTTGTTGC	0.294000													17	35					0	0	1	0	0
ZNF766	90321	broad.mit.edu	37	19	52785399	52785399	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:52785399C>T	ENST00000439461.1	+	2	97	c.54C>T	c.(52-54)ttC>ttT	p.F18F	ZNF766_ENST00000359102.4_Silent_p.F33F|ZNF766_ENST00000593612.1_Silent_p.F33F|ZNF766_ENST00000600821.1_Silent_p.F13F|ZNF766_ENST00000599581.1_Silent_p.F18F	NM_001010851.2	NP_001010851.1	Q5HY98	ZN766_HUMAN	zinc finger protein 766	18	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	17				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		CCATAGAATTCTCTCAGGAGG	0.453000													41	109					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23703323	23703323	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:23703323G>A	ENST00000256797.4	-	19	2649	c.2481C>T	c.(2479-2481)ccC>ccT	p.P827P	ERN2_ENST00000457008.2_Silent_p.P727P	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	779	KEN.				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		TCCAAAAGAAGGGGTGGGCCA	0.597000													144	142					0	0	1	0	0
TCOF1	6949	broad.mit.edu	37	5	149772279	149772279	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:149772279C>T	ENST00000451292.1	+	23	3745	c.3637C>T	c.(3637-3639)Ccc>Tcc	p.P1213S	TCOF1_ENST00000445265.2_Missense_Mutation_p.P1100S|TCOF1_ENST00000504761.2_Missense_Mutation_p.P1176S|TCOF1_ENST00000439160.2_Missense_Mutation_p.P1139S|TCOF1_ENST00000377797.3_Missense_Mutation_p.P1177S|TCOF1_ENST00000513346.1_Missense_Mutation_p.P1176S|TCOF1_ENST00000323668.7_Missense_Mutation_p.P1099S			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	1176					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGTCCCACCCCCTCCAGGAC	0.637000													15	4					0	0	1	0	0
OR1G1	8390	broad.mit.edu	37	17	3030711	3030711	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:3030711G>A	ENST00000328890.2	-	1	164	c.135C>T	c.(133-135)atC>atT	p.I45I		NM_003555.1	NP_003546.1	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G, member 1	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(3)|skin(3)	11						TGACTAGAATGATGAGGAGGT	0.527000													27	44					0	0	1	0	0
MUC21	394263	broad.mit.edu	37	6	30955199	30955199	+	Missense_Mutation	SNP	G	G	A	rs55803740		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:30955199G>A	ENST00000376296.3	+	2	1488	c.1247G>A	c.(1246-1248)gGg>gAg	p.G416E	MUC21_ENST00000486149.2_5'UTR	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	416	28 X 15 AA approximate tandem repeats.|Ser-rich.					integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						GTGTCCAGTGGGGCCAGCACT	0.622000													30	222					0	0	1	0	0
SPATA21	374955	broad.mit.edu	37	1	16748444	16748444	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:16748444G>A	ENST00000335496.1	-	4	539	c.57C>T	c.(55-57)ttC>ttT	p.F19F	SPATA21_ENST00000466212.1_5'UTR|SPATA21_ENST00000540400.1_Intron	NM_198546.1	NP_940948.1	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	19							calcium ion binding			breast(1)|endometrium(2)|lung(8)|ovary(2)|pancreas(3)|stomach(1)|urinary_tract(2)	19		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		TGGATGGCAGGAAGGGGTTGA	0.577000													99	32					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135430444	135430444	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:135430444A>G	ENST00000394143.1	+	6	4870	c.4579A>G	c.(4579-4581)Aaa>Gaa	p.K1527E	GPR112_ENST00000370652.1_Missense_Mutation_p.K1527E|GPR112_ENST00000412101.1_Missense_Mutation_p.K1322E|GPR112_ENST00000287534.4_Missense_Mutation_p.K1464E|GPR112_ENST00000394141.1_Missense_Mutation_p.K1322E	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1527					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CACCTCCAAAAAAGTTTCTGA	0.428000													37	40					0	0	1	0	0
FPR2	2358	broad.mit.edu	37	19	52272265	52272265	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:52272265C>T	ENST00000598776.1	+	2	1126	c.354C>T	c.(352-354)ttC>ttT	p.F118F	FPR2_ENST00000340023.6_Silent_p.F118F|FPR2_ENST00000598953.1_Silent_p.F118F	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	118					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						TGATTGGTTTCATTGCACTGG	0.507000													33	24					0	0	1	0	0
DTNA	1837	broad.mit.edu	37	18	32398181	32398181	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:32398181C>T	ENST00000283365.9	+	9	1114	c.763C>T	c.(763-765)Cgc>Tgc	p.R255C	DTNA_ENST00000601125.1_5'UTR|DTNA_ENST00000348997.5_Missense_Mutation_p.R255C|DTNA_ENST00000315456.6_Missense_Mutation_p.R255C|DTNA_ENST00000596745.1_Intron|DTNA_ENST00000399113.3_Missense_Mutation_p.R255C|DTNA_ENST00000269190.7_Missense_Mutation_p.R255C|DTNA_ENST00000554864.3_Missense_Mutation_p.R255C|DTNA_ENST00000598334.1_Missense_Mutation_p.R255C|DTNA_ENST00000597599.1_Missense_Mutation_p.R255C|DTNA_ENST00000444659.1_Missense_Mutation_p.R255C|DTNA_ENST00000399097.3_5'UTR|DTNA_ENST00000598774.1_Missense_Mutation_p.R255C|DTNA_ENST00000595022.1_Missense_Mutation_p.R255C|DTNA_ENST00000399121.5_Missense_Mutation_p.R255C|DTNA_ENST00000598142.1_Missense_Mutation_p.R255C|DTNA_ENST00000269191.6_Missense_Mutation_p.R255C	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	255	Interaction with MAGEE1 (By similarity).				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						GATGGGATTTCGCTACCGATG	0.468000													26	17					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093396	30093396	+	RNA	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:30093396C>T	ENST00000567636.1	+	0	1771					NR_003558.1																						CTGGGCTTTTCCCACCAGCTC	0.502000													30	26					0	0	1	0	0
CTD-2192J16.20	0	broad.mit.edu	37	19	12691762	12691762	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:12691762G>A	ENST00000593682.1	-	1	27	c.28C>T	c.(28-30)Cct>Tct	p.P10S	ZNF490_ENST00000311437.6_Missense_Mutation_p.S376F																							CACTTCACAGGAACTAGATGA	0.403000													33	28					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12639595	12639595	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:12639595C>T	ENST00000425538.1	+	6	733	c.533C>T	c.(532-534)tCc>tTc	p.S178F	MYOCD_ENST00000395988.1_Missense_Mutation_p.S82F|MYOCD_ENST00000343344.4_Missense_Mutation_p.S178F	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	178	HDAC5-binding (By similarity).				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TCAGCGGGATCCCCGCCAGAC	0.493000													33	68					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	167020663	167020663	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:167020663G>A	ENST00000061240.2	+	20	3538	c.2891G>A	c.(2890-2892)cGa>cAa	p.R964Q	TLL1_ENST00000507499.1_Missense_Mutation_p.R987Q	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	964	CUB 5.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.R964P(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GGGCTTGGTCGATTCTGTGGA	0.423000													45	60					0	0	1	0	0
USP4	7375	broad.mit.edu	37	3	49323590	49323590	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:49323590G>A	ENST00000351842.4	-	15	2008	c.2000C>T	c.(1999-2001)tCc>tTc	p.S667F	USP4_ENST00000265560.4_Missense_Mutation_p.S714F	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	714					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		TGTTCCATAGGAGTTCACAAG	0.458000													14	34					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113642835	113642835	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:113642835T>C	ENST00000361127.4	+	10	1373	c.1175T>C	c.(1174-1176)aTc>aCc	p.I392T		NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	392						cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TATTTCAGAATCTTACAAGGA	0.303000													9	13					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92761298	92761298	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:92761298C>T	ENST00000318238.4	-	5	5203	c.3987G>A	c.(3985-3987)agG>agA	p.R1329R	SAMD9L_ENST00000411955.1_Silent_p.R1329R|SAMD9L_ENST00000437805.1_Silent_p.R1329R	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1329										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CTAGCTTTTTCCTGCAATTCT	0.388000													39	79					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156622586	156622586	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:156622586C>T	ENST00000329117.4	+	8	2180	c.1844C>T	c.(1843-1845)tCt>tTt	p.S615F	RP11-284F21.7_ENST00000448869.1_RNA|BCAN_ENST00000361588.5_Missense_Mutation_p.S615F	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	615					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GAAGATAATTCTGGAAGAACT	0.662000													23	13					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242264024	242264024	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:242264024A>T	ENST00000442594.2	-	10	1533	c.1024T>A	c.(1024-1026)Ttt>Att	p.F342I	PLD5_ENST00000427495.1_Missense_Mutation_p.F372I|PLD5_ENST00000536534.1_Missense_Mutation_p.F434I	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	434						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			AACCTAGGAAAGGTGTGATTC	0.428000													24	42					0	0	1	0	0
SPHK2	56848	broad.mit.edu	37	19	49129484	49129484	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:49129484G>A	ENST00000443164.1	+	1	1267	c.562G>A	c.(562-564)Ggg>Agg	p.G188R	SPHK2_ENST00000599029.1_Missense_Mutation_p.G90R|SPHK2_ENST00000601712.1_Missense_Mutation_p.G90R|SPHK2_ENST00000599748.1_Missense_Mutation_p.G90R|SPHK2_ENST00000599033.1_3'UTR|SPHK2_ENST00000598088.1_Missense_Mutation_p.G126R|SPHK2_ENST00000600537.1_Missense_Mutation_p.G67R|SPHK2_ENST00000245222.4_Missense_Mutation_p.G126R|SPHK2_ENST00000340932.3_Missense_Mutation_p.G90R			Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	126	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		gggccggcgcggggcccggcg	0.711000													14	6					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158224882	158224882	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:158224882G>A	ENST00000289429.5	+	2	600	c.67G>A	c.(67-69)Gag>Aag	p.E23K		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	23					antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	AGGGCTCAAGGAGCCTCTCTC	0.483000													23	36					0	0	1	0	0
NPAS2	4862	broad.mit.edu	37	2	101587519	101587519	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:101587519C>T	ENST00000335681.5	+	12	1408	c.1123C>T	c.(1123-1125)Cac>Tac	p.H375Y	NPAS2_ENST00000542504.1_Missense_Mutation_p.H440Y	NM_002518.3	NP_002509.2	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	375					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity	p.H375Y(1)		cervix(1)|endometrium(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CGAGGCCCTCCACTCCTCAGC	0.542000													20	50					0	0	1	0	0
PSG1	5669	broad.mit.edu	37	19	43382351	43382351	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:43382351C>T	ENST00000244296.2	-	2	281	c.144G>A	c.(142-144)ggG>ggA	p.G48G	PSG1_ENST00000595124.1_Silent_p.G48G|PSG1_ENST00000403380.3_Silent_p.G48G|PSG1_ENST00000601073.1_5'UTR|PSG1_ENST00000436291.2_Silent_p.G48G|PSG1_ENST00000312439.6_Silent_p.G48G|PSG1_ENST00000595356.1_Silent_p.G48G	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				GAACATCCTTCCCCTCGGAAA	0.478000													43	108					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128608	152128608	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:152128608C>T	ENST00000316073.3	-	3	1031	c.967G>A	c.(967-969)Gac>Aac	p.D323N		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	323	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						CCTTGTCTGTCCGTCTGACTG	0.498000													302	379					0	0	1	0	0
AMIGO2	347902	broad.mit.edu	37	12	47471912	47471912	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:47471912G>A	ENST00000266581.4	-	2	1340	c.874C>T	c.(874-876)Cgt>Tgt	p.R292C	AMIGO2_ENST00000429635.1_Missense_Mutation_p.R292C|AMIGO2_ENST00000550413.1_Missense_Mutation_p.R292C|AMIGO2_ENST00000321382.3_Missense_Mutation_p.R292C	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	292	Ig-like C2-type.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					CCAAGCGCACGAAAGGAACCA	0.512000													40	5					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109383173	109383173	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:109383173T>G	ENST00000283195.6	+	20	6304	c.6178T>G	c.(6178-6180)Tta>Gta	p.L2060V		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	2060	RanBD1 2.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						CTTGGGGAACTTAAAAATTCT	0.383000													81	273					0	0	1	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104206311	104206311	+	Silent	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:104206311G>T	ENST00000202556.9	-	12	2724	c.2442C>A	c.(2440-2442)gcC>gcA	p.A814A	PPP1R13B_ENST00000555391.1_5'UTR|PPP1R13B_ENST00000423488.2_Silent_p.A233A	NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	814	Pro-rich.				apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				CTGCCGGCTCGGCAGTTTGGT	0.607000													22	2					1.28384e-07	1.29338e-07	1	1	0
SLCO1B7	338821	broad.mit.edu	37	12	21168658	21168658	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:21168658G>A	ENST00000421593.2	+	1	29	c.29G>A	c.(28-30)aGg>aAg	p.R10K	SLCO1B3_ENST00000553473.1_Intron|LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000381541.3_Intron	NM_001009562.4	NP_001009562.3			solute carrier organic anion transporter family, member 1B7 (non-functional)											endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(25)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						CAAATAGAAAGGAGATTTGAG	0.328000													2	2					0	0	1	0	0
RAB19	401409	broad.mit.edu	37	7	140111659	140111659	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:140111659C>T	ENST00000275874.5	+	4	526	c.328C>T	c.(328-330)Cct>Tct	p.P110S	RAB19_ENST00000537763.1_Intron|RAB19_ENST00000356407.3_Intron			A4D1S5	RAB19_HUMAN	RAB19, member RAS oncogene family	67					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			breast(3)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	9	Melanoma(164;0.0142)					GACTCTCCTTCCTGTCCTTCT	0.527000													15	46					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70066197	70066197	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:70066197C>T	ENST00000446444.1	-	6	1559	c.1551G>A	c.(1549-1551)tgG>tgA	p.W517*	RP11-704M14.1_ENST00000504301.1_RNA|RP11-704M14.1_ENST00000505646.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	517					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						TAGCAAACTTCCAGAAACAAA	0.403000													28	42					0	0	1	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115515061	115515061	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr10:115515061C>T	ENST00000361048.1	+	2	352	c.25C>T	c.(25-27)Cca>Tca	p.P9S	PLEKHS1_ENST00000369312.4_5'UTR	NM_024889.4	NP_079165.3			pleckstrin homology domain containing, family S member 1																		TCAGAAGAGTCCAGGTACCCG	0.458000													5	16					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23863310	23863310	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:23863310C>T	ENST00000405093.3	-	21	2722	c.2652G>A	c.(2650-2652)caG>caA	p.Q884Q	MYH6_ENST00000356287.3_Silent_p.Q884Q	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	884					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CATTCTTCTCCTGCAGCAGGG	0.577000													21	1					0	0	1	0	0
C11orf88	399949	broad.mit.edu	37	11	111385573	111385573	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:111385573G>A	ENST00000529167.1	+	1	64	c.64G>A	c.(64-66)Gga>Aga	p.G22R	C11orf88_ENST00000332814.6_Missense_Mutation_p.G22R|C11orf88_ENST00000375618.4_Missense_Mutation_p.G22R|RP11-794P6.6_ENST00000530283.1_RNA			Q6PI97	CK088_HUMAN	chromosome 11 open reading frame 88	22										endometrium(1)|large_intestine(3)|lung(2)	6						GTGCCCCCCGGGATTACTGGT	0.567000											OREG0021329	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	22					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13923946	13923946	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:13923946C>T	ENST00000254323.2	+	6	1337	c.1148C>T	c.(1147-1149)cCc>cTc	p.P383L	ZSWIM4_ENST00000440752.2_Missense_Mutation_p.P100L	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	383							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			TTCGACGGCCCCAGCCTGCAG	0.612000													19	9					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681847	100681847	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:100681847G>A	ENST00000306151.4	+	3	7214	c.7150G>A	c.(7150-7152)Gat>Aat	p.D2384N		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2384	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTGCTGACGATACTAGCAT	0.498000													63	235					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37922621	37922621	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:37922621C>T	ENST00000346872.3	-	8	1013	c.952G>A	c.(952-954)Gaa>Aaa	p.E318K	IKZF3_ENST00000350532.3_Missense_Mutation_p.E279K|IKZF3_ENST00000394189.2_Missense_Mutation_p.E136K|IKZF3_ENST00000583368.1_Missense_Mutation_p.E71K|IKZF3_ENST00000467757.1_Missense_Mutation_p.E262K|IKZF3_ENST00000346243.3_Missense_Mutation_p.E240K|IKZF3_ENST00000377945.3_Missense_Mutation_p.E184K|IKZF3_ENST00000535189.1_Missense_Mutation_p.E284K|IKZF3_ENST00000439016.2_Missense_Mutation_p.E223K|IKZF3_ENST00000439167.2_Missense_Mutation_p.E245K|IKZF3_ENST00000377944.3_Missense_Mutation_p.E175K|IKZF3_ENST00000377952.2_Missense_Mutation_p.E97K|IKZF3_ENST00000377958.2_Missense_Mutation_p.E231K|IKZF3_ENST00000351680.3_Missense_Mutation_p.E279K	NM_012481.4	NP_036613.2	Q9UKT9	IKZF3_HUMAN	IKAROS family zinc finger 3 (Aiolos)	318					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(6)|large_intestine(4)|liver(1)|lung(13)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CGCAGGGCTTCGGCGCCAAGA	0.532000													16	47					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72937553	72937553	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:72937553G>A	ENST00000328801.4	+	2	139	c.139G>A	c.(139-141)Gag>Aag	p.E47K		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	47						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					CCCGGAGAAGGAGAACCGAGT	0.637000													13	10					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47331627	47331627	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:47331627G>A	ENST00000398879.1	-	27	4220	c.3854C>T	c.(3853-3855)cCa>cTa	p.P1285L	TNS3_ENST00000311160.9_Missense_Mutation_p.P1285L|TNS3_ENST00000355730.3_Missense_Mutation_p.P1045L			Q68CZ2	TENS3_HUMAN	tensin 3	1285						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						TTCCTCCAATGGATCTGTAGG	0.468000													7	34					0	0	1	0	0
LRRC61	65999	broad.mit.edu	37	7	150034116	150034116	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:150034116G>A	ENST00000359623.4	+	3	754	c.166G>A	c.(166-168)Gag>Aag	p.E56K	LRRC61_ENST00000493307.1_Missense_Mutation_p.E56K|LRRC61_ENST00000323078.7_Missense_Mutation_p.E56K	NM_001142928.1	NP_001136400.1	Q9BV99	LRC61_HUMAN	leucine rich repeat containing 61	56										endometrium(2)|large_intestine(1)|skin(1)|upper_aerodigestive_tract(1)	5			OV - Ovarian serous cystadenocarcinoma(82;0.011)			CCTGGGCCTGGAGTGGCTGGA	0.647000													57	38					0	0	1	0	0
TC2N	123036	broad.mit.edu	37	14	92265383	92265383	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:92265383G>A	ENST00000435962.2	-	6	910	c.587C>T	c.(586-588)cCc>cTc	p.P196L	TC2N_ENST00000556018.1_Missense_Mutation_p.P196L|TC2N_ENST00000360594.5_Missense_Mutation_p.P196L|TC2N_ENST00000340892.5_Missense_Mutation_p.P196L	NM_001128596.1	NP_001122068.1	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	196						nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		AGAACTACTGGGTACACTGGA	0.323000													6	12					0	0	1	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64138933	64138933	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:64138933C>T	ENST00000295902.6	-	6	1297	c.712G>A	c.(712-714)Gag>Aag	p.E238K	PRICKLE2_ENST00000564377.1_Missense_Mutation_p.E294K	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	238	LIM zinc-binding 2.					cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		GGTCTTCCCTCCTTCATGATG	0.512000													59	44					0	0	1	0	0
PDZK1	5174	broad.mit.edu	37	1	145762276	145762276	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:145762276A>T	ENST00000344770.2	+	8	1526	c.1453A>T	c.(1453-1455)Aaa>Taa	p.K485*	PDZK1_ENST00000465595.1_3'UTR|PDZK1_ENST00000417171.1_Nonsense_Mutation_p.K485*|PDZK1_ENST00000451928.2_Nonsense_Mutation_p.K374*	NM_002614.4	NP_002605.2	Q5T2W1	NHRF3_HUMAN	PDZ domain containing 1	485					carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity			NS(1)|endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	7	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			TCCAGATTCTAAAGAAGGAAT	0.438000													24	21					0	0	1	0	0
CEACAM19	56971	broad.mit.edu	37	19	45179670	45179670	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:45179670G>A	ENST00000358777.4	+	3	1032	c.552G>A	c.(550-552)agG>agA	p.R184R	CTB-171A8.1_ENST00000590796.1_RNA|CEACAM19_ENST00000480278.1_3'UTR|CEACAM19_ENST00000403660.3_Silent_p.R184R	NM_001127893.1|NM_020219.3	NP_001121365.1|NP_064604.2	Q7Z692	CEA19_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 19	184						integral to membrane				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)	11	Lung NSC(12;0.00308)|all_lung(12;0.00806)	Prostate(69;0.0376)				TGGTGACAAGGAACTGGAGGG	0.592000													14	46					0	0	1	0	0
GPR113	165082	broad.mit.edu	37	2	26536765	26536765	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:26536765G>T	ENST00000333478.6	-	5	1124	c.542C>A	c.(541-543)tCc>tAc	p.S181Y	GPR113_ENST00000311519.1_Missense_Mutation_p.S380Y|GPR113_ENST00000459892.1_5'UTR|GPR113_ENST00000421160.2_Missense_Mutation_p.S311Y|GPR113_ENST00000541401.1_5'UTR	NM_153835.3	NP_722577.2	Q8IZF5	GP113_HUMAN	G protein-coupled receptor 113	380					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCGTTGAAGGAGGAAGCTGA	0.567000													37	14					1.59932e-28	1.63245e-28	1	1	0
HSPG2	3339	broad.mit.edu	37	1	22207308	22207308	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:22207308G>A	ENST00000374695.3	-	15	1918	c.1839C>T	c.(1837-1839)tcC>tcT	p.S613S		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	613	Laminin IV type A 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGTAACGCAGGGAGCCGCCAT	0.642000													6	1					0	0	1	0	0
MYLIP	29116	broad.mit.edu	37	6	16143273	16143273	+	Silent	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:16143273T>C	ENST00000356840.3	+	4	685	c.487T>C	c.(487-489)Ttg>Ctg	p.L163L	MYLIP_ENST00000349606.4_5'UTR	NM_013262.3	NP_037394.2	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting protein	163	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			ACATAAGGAGTTGGAGGGGAC	0.438000													3	16					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62855832	62855832	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:62855832T>C	ENST00000584306.1	-	11	4962	c.4432A>G	c.(4432-4434)Acc>Gcc	p.T1478A	LRRC37A3_ENST00000319651.5_Missense_Mutation_p.T1478A|LRRC37A3_ENST00000334962.5_Missense_Mutation_p.T455A|LRRC37A3_ENST00000339474.5_Missense_Mutation_p.T596A|LRRC37A3_ENST00000400877.3_Missense_Mutation_p.T516A	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1478						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						AGCTGCTGGGTTAGCTGAATT	0.517000													109	71					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25715926	25715926	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:25715926C>T	ENST00000520164.1	-	14	1974	c.1437G>A	c.(1435-1437)atG>atA	p.M479I	EBF2_ENST00000535548.1_Missense_Mutation_p.M210I|EBF2_ENST00000408929.3_Missense_Mutation_p.M331I	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	479	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TGTAGCCATTCATACTGTTGC	0.522000													9	26					0	0	1	0	0
SPAG11B	10407	broad.mit.edu	37	8	7308374	7308374	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:7308374C>T	ENST00000398462.2	-	3	413	c.263G>A	c.(262-264)gGg>gAg	p.G88E	SPAG11B_ENST00000297498.2_3'UTR|SPAG11B_ENST00000359758.5_Missense_Mutation_p.G88E|SPAG11B_ENST00000528168.1_3'UTR|SPAG11B_ENST00000458665.1_Missense_Mutation_p.G35E|SPAG11B_ENST00000361111.2_Intron	NM_058201.2	NP_478108.2	Q08648	SG11B_HUMAN	sperm associated antigen 11B	0					spermatogenesis	extracellular region				large_intestine(2)|lung(3)|urinary_tract(1)	6				COAD - Colon adenocarcinoma(149;0.0162)|READ - Rectum adenocarcinoma(644;0.236)		TCTGCAGATCCCTTGCTGCAT	0.418000													29	35					0	0	1	0	0
GAREM	64762	broad.mit.edu	37	18	29867531	29867531	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:29867531G>A	ENST00000399218.4	-	4	1084	c.1029C>T	c.(1027-1029)gtC>gtT	p.V343V	RP11-344B2.2_ENST00000579580.1_RNA|GAREM_ENST00000269209.6_Silent_p.V343V	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		TCACATCACGGACAGCCCGTG	0.562000													30	20					0	0	1	0	0
NLRC4	58484	broad.mit.edu	37	2	32475374	32475374	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:32475374C>T	ENST00000404025.2	-	5	2047	c.1559G>A	c.(1558-1560)gGa>gAa	p.G520E	NLRC4_ENST00000342905.6_Intron|NLRC4_ENST00000360906.5_Missense_Mutation_p.G520E|NLRC4_ENST00000402280.1_Missense_Mutation_p.G520E			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	520					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GATGGAAAGTCCGAGAAGGCA	0.502000													22	13					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156816326	156816326	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:156816326G>A	ENST00000368195.3	-	8	2191	c.1795C>T	c.(1795-1797)Cga>Tga	p.R599*	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	599					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity	p.R599*(2)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGCAGCGTTCGGAGGTAGACG	0.577000													15	18					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168107021	168107021	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:168107021G>A	ENST00000409195.1	+	9	9208	c.9119G>A	c.(9118-9120)gGa>gAa	p.G3040E	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.G2818E|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.G3040E|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2865					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TCCAAAACAGGAAAACCGGGA	0.318000													39	48					0	0	1	0	0
CEACAM19	56971	broad.mit.edu	37	19	45179669	45179669	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:45179669G>A	ENST00000358777.4	+	3	1031	c.551G>A	c.(550-552)aGg>aAg	p.R184K	CTB-171A8.1_ENST00000590796.1_RNA|CEACAM19_ENST00000480278.1_3'UTR|CEACAM19_ENST00000403660.3_Missense_Mutation_p.R184K	NM_001127893.1|NM_020219.3	NP_001121365.1|NP_064604.2	Q7Z692	CEA19_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 19	184						integral to membrane				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)	11	Lung NSC(12;0.00308)|all_lung(12;0.00806)	Prostate(69;0.0376)				CTGGTGACAAGGAACTGGAGG	0.592000													14	45					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33134304	33134304	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:33134304G>A	ENST00000341947.2	-	60	4605	c.4378C>T	c.(4378-4380)Ccc>Tcc	p.P1460S	COL11A2_ENST00000374712.1_Missense_Mutation_p.P1379S|COL11A2_ENST00000374714.1_Missense_Mutation_p.P1434S|COL11A2_ENST00000395197.1_Missense_Mutation_p.P1400S|COL11A2_ENST00000361917.1_Missense_Mutation_p.P1353S|COL11A2_ENST00000374708.4_Missense_Mutation_p.P1374S|COL11A2_ENST00000374713.1_Missense_Mutation_p.P1413S|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000357486.1_Missense_Mutation_p.P1439S	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1460	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						AGGCCGGGGGGACCTCCAGGA	0.617000													52	12					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195491986	195491986	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:195491986C>T	ENST00000463781.3	-	10	14265	c.13806G>A	c.(13804-13806)tgG>tgA	p.W4602*	MUC4_ENST00000349607.4_Nonsense_Mutation_p.W315*|MUC4_ENST00000346145.4_Nonsense_Mutation_p.W366*|MUC4_ENST00000475231.1_Nonsense_Mutation_p.W4550*	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1359					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGCCGAGGCCCCAGCGACCTG	0.667000													12	11					0	0	1	0	0
ASB18	401036	broad.mit.edu	37	2	237150126	237150126	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:237150126T>C	ENST00000330842.6	-	1	132	c.38A>G	c.(37-39)cAa>cGa	p.Q13R	ASB18_ENST00000409749.3_Intron|AC079135.1_ENST00000415226.1_RNA			Q6ZVZ8	ASB18_HUMAN	ankyrin repeat and SOCS box containing 18	0					intracellular signal transduction					large_intestine(1)|lung(3)|ovary(1)|prostate(1)	6		all_hematologic(139;0.00615)|Renal(207;0.00963)|Breast(86;0.0126)|Acute lymphoblastic leukemia(138;0.0815)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)|GBM - Glioblastoma multiforme(43;0.244)		TTGAAATATTTGAAGTTTTCC	0.517000													3	5					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22729483	22729483	+	RNA	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:22729483C>T	ENST00000511446.1	+	0	61				GBA3_ENST00000508166.1_RNA|GBA3_ENST00000503442.1_RNA	NM_001277225.1	NP_001264154.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GGTACATATTCCGATGGAAAT	0.393000													32	47					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46832714	46832714	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:46832714C>T	ENST00000339613.2	+	12	1778	c.1523C>T	c.(1522-1524)cCc>cTc	p.P508L	HIF3A_ENST00000472815.1_Intron|HIF3A_ENST00000420102.2_Missense_Mutation_p.P513L|HIF3A_ENST00000377670.4_Missense_Mutation_p.P564L|HIF3A_ENST00000600383.1_Missense_Mutation_p.P495L|HIF3A_ENST00000244303.6_Missense_Mutation_p.P495L|HIF3A_ENST00000300862.3_Missense_Mutation_p.P562L|AC007193.10_ENST00000596807.1_RNA			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	564	ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		GCATCCTCTCCCATGGCTGGG	0.662000													3	6					0	0	1	0	0
KRT80	144501	broad.mit.edu	37	12	52565324	52565324	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:52565324G>A	ENST00000313234.5	-	9	1349	c.1252C>T	c.(1252-1254)Ccc>Tcc	p.P418S	KRT80_ENST00000394815.2_Intron	NM_001081492.1	NP_001074961.1	Q6KB66	K2C80_HUMAN	keratin 80	0	Tail.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		GAACATAAGGGGTAGGGGAGG	0.562000													19	23					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11418775	11418775	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:11418775G>A	ENST00000423059.3	-	26	4974	c.4723C>T	c.(4723-4725)Cgg>Tgg	p.R1575W	AC004538.3_ENST00000421121.1_RNA|AC004538.3_ENST00000595972.1_RNA|AC004538.3_ENST00000445839.1_RNA|AC004538.3_ENST00000428967.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1575						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TGTACAGCCCGACTGGTTTTC	0.512000										HNSCC(18;0.044)			17	25					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139767407	139767407	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:139767407C>T	ENST00000303045.6	-	21	2470	c.2024G>A	c.(2023-2025)gGa>gAa	p.G675E	COL22A1_ENST00000435777.1_Missense_Mutation_p.G675E	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	675	Collagen-like 4.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TACCCGAGCTCCTGGAGGACC	0.557000										HNSCC(7;0.00092)			25	121					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101777034	101777034	+	Splice_Site	SNP	T	T	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:101777034T>G	ENST00000251127.6	-	18	2200		c.e18-2			NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective							integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTTGCGAAGCTGAAAATGATA	0.333000													13	31					0	0	1	0	0
ASIC2	40	broad.mit.edu	37	17	32483253	32483253	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:32483253G>A	ENST00000359872.6	-	1	1060	c.299C>T	c.(298-300)tCc>tTc	p.S100F		NM_001094.4	NP_001085.2	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	100					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	GGTGAGCCTGGAGAACCGGAA	0.587000													28	13					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109660610	109660610	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:109660610A>T	ENST00000338432.7	+	26	3804	c.3685A>T	c.(3685-3687)Att>Ttt	p.I1229F	ACACB_ENST00000377848.3_Missense_Mutation_p.I1229F|ACACB_ENST00000377854.5_Missense_Mutation_p.I1159F			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1229					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	GCAGATCCTGATTGCCTCCCA	0.647000													14	2					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175896957	175896957	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:175896957C>A	ENST00000359240.3	+	5	951	c.281C>A	c.(280-282)cCa>cAa	p.P94Q	ADAM29_ENST00000514159.1_Missense_Mutation_p.P94Q|ADAM29_ENST00000404450.4_Missense_Mutation_p.P94Q|ADAM29_ENST00000445694.1_Missense_Mutation_p.P94Q	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	94					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GAGGACCAGCCATTTGTCCAG	0.448000													18	27					5.01169e-05	5.03026e-05	1	1	0
C1orf141	400757	broad.mit.edu	37	1	67559156	67559156	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:67559156G>A	ENST00000371007.2	-	8	844	c.735C>T	c.(733-735)ttC>ttT	p.F245F	C1orf141_ENST00000371006.1_Silent_p.F245F|C1orf141_ENST00000544837.1_Silent_p.F245F	NM_001276351.1	NP_001263280.1	Q5JVX7	CA141_HUMAN	chromosome 1 open reading frame 141	245										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18						TTTCTAAAATGAAATTTGTTC	0.289000													6	22					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142479988	142479988	+	RNA	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:142479988C>T	ENST00000603901.1	+	0	120					NR_001296.3																						ACCAGGTGTCCTTGAATTCTG	0.557000													80	53					0	0	1	0	0
CD2	914	broad.mit.edu	37	1	117297465	117297465	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:117297465C>T	ENST00000369478.3	+	2	382	c.274C>T	c.(274-276)Ctg>Ttg	p.L92L	CD2_ENST00000369477.1_Silent_p.L92L	NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	92	Ig-like V-type.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	AAATGGAACTCTGAAAATTAA	0.289000													18	12					0	0	1	0	0
HLA-V	352962	broad.mit.edu	37	6	29760103	29760103	+	RNA	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:29760103G>A	ENST00000457107.1	+	0	83																											GGTCGGGAGGGAAACGGCGTC	0.726000													4	16					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50099989	50099989	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:50099989C>T	ENST00000418929.2	+	4	2409	c.2397C>T	c.(2395-2397)ccC>ccT	p.P799P		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	490							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CGCCTCCCCCCCAGCTGCTCC	0.721000													8	11					0	0	1	0	0
NHSL2	340527	broad.mit.edu	37	X	71360099	71360099	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:71360099A>G	ENST00000373677.1	+	2	2865	c.1603A>G	c.(1603-1605)Acc>Gcc	p.T535A	NHSL2_ENST00000540800.1_Missense_Mutation_p.T901A|NHSL2_ENST00000510661.1_Missense_Mutation_p.T670A|NHSL2_ENST00000535692.1_Missense_Mutation_p.T535A			F5H593	F5H593_HUMAN	NHS-like 2	901										NS(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(10)|lung(7)|stomach(1)	28	Renal(35;0.156)					AACTTCACCAACCTTGGCTAT	0.567000													17	36					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38753883	38753883	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:38753883G>A	ENST00000449082.2	-	22	3857	c.3858C>T	c.(3856-3858)ctC>ctT	p.L1286L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1286					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGAGGCAGACGAGGAGGACAT	0.552000													34	30					0	0	1	0	0
ASUN	55726	broad.mit.edu	37	12	27078748	27078748	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:27078748G>A	ENST00000261191.7	-	6	1157	c.621C>T	c.(619-621)atC>atT	p.I207I	ASUN_ENST00000539625.1_Silent_p.I106I	NM_018164.2	NP_060634.2	Q9NVM9	M89BB_HUMAN	asunder spermatogenesis regulator	207					cell division|mitosis|regulation of mitotic cell cycle		protein binding										GGTAGGTGTGGATCAAGACCA	0.323000													18	8					0	0	1	0	0
SLC22A2	6582	broad.mit.edu	37	6	160664772	160664772	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:160664772G>A	ENST00000366953.3	-	7	1369	c.1111C>T	c.(1111-1113)Ctt>Ttt	p.L371F	SLC22A2_ENST00000491092.1_5'UTR	NM_003058.3	NP_003049.2	O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	371					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		TCACCTGCAAGGCCCATGTGC	0.532000													12	19					0	0	1	0	0
WDR13	64743	broad.mit.edu	37	X	48463292	48463292	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:48463292G>A	ENST00000218056.5	+	9	1835	c.1330G>A	c.(1330-1332)Gct>Act	p.A444T		NM_001166426.1|NM_017883.4	NP_001159898.1|NP_060353.2	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13	444						cytoplasm|nucleus				endometrium(1)|large_intestine(4)|lung(4)|ovary(2)	11						GGCGGCCAAGGCTGCTGTCAA	0.632000													21	15					0	0	1	0	0
GDPD2	54857	broad.mit.edu	37	X	69649858	69649858	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:69649858G>A	ENST00000453994.2	+	12	1613	c.1252G>A	c.(1252-1254)Gag>Aag	p.E418K	GDPD2_ENST00000472623.1_3'UTR|GDPD2_ENST00000536730.1_Missense_Mutation_p.E339K|GDPD2_ENST00000538649.1_Missense_Mutation_p.E339K|GDPD2_ENST00000374382.3_Missense_Mutation_p.E418K	NM_001171192.1	NP_001164663.1	Q9HCC8	GDPD2_HUMAN	glycerophosphodiester phosphodiesterase domain containing 2	418	GDPD.			E -> G (in Ref. 3; BAA91014).	glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|large_intestine(8)|lung(3)|ovary(2)	22	Renal(35;0.156)					CAACAGAACGGAGAGGCCCCA	0.507000													22	24					0	0	1	0	0
LOC647323	647323	broad.mit.edu	37	3	193711760	193711760	+	RNA	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:193711760G>A	ENST00000397645.2	-	0	75				RP11-699L21.2_ENST00000426616.1_lincRNA	NR_033944.1																						GGTCGGCAAGGGAAGGGCTGG	0.433000													9	16					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31323668	31323668	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:31323668C>T	ENST00000269197.5	+	12	3856	c.3856C>T	c.(3856-3858)Cag>Tag	p.Q1286*		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1286	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						AAAAACCATCCAGGGAACTGA	0.413000													8	30					0	0	1	0	0
CSF1	1435	broad.mit.edu	37	1	110465834	110465834	+	Silent	SNP	C	C	T	rs140214194		TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:110465834C>T	ENST00000329608.6	+	6	982	c.591C>T	c.(589-591)atC>atT	p.I197I	CSF1_ENST00000369802.3_Silent_p.I197I|CSF1_ENST00000344188.5_Silent_p.I197I|CSF1_ENST00000420111.2_Intron|CSF1_ENST00000369801.1_Silent_p.I197I	NM_000757.5|NM_172211.3	NP_000748.3|NP_757350.1	P09603	CSF1_HUMAN	colony stimulating factor 1 (macrophage)	197					cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			breast(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCAAAGCCATCCCTAGCAGTG	0.587000											OREG0013645	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	78	38					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207173257	207173257	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:207173257C>T	ENST00000374423.3	+	5	4391	c.4005C>T	c.(4003-4005)atC>atT	p.I1335I		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1335							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TTTCAAATATCCCTCTTCAGT	0.383000													16	18					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16025448	16025448	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:16025448C>T	ENST00000402119.3	-	10	1704	c.1278G>A	c.(1276-1278)ggG>ggA	p.G426G	CYP4F11_ENST00000248041.7_Silent_p.G426G|CYP4F11_ENST00000326742.7_Intron	NM_021187.3	NP_067010.3	Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	426					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						TGTAATGGATCCCGATAATAT	0.572000													30	44					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140406746	140406746	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:140406746G>A	ENST00000286349.3	+	3	1413	c.1222G>A	c.(1222-1224)Gaa>Aaa	p.E408K		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	408						intracellular	zinc ion binding	p.E408K(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						CAGGCAGAAGGAAATTGAAAA	0.453000													9	26					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28986101	28986101	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:28986101C>T	ENST00000359747.4	+	12	1727	c.1698C>T	c.(1696-1698)atC>atT	p.I566I	RP11-534N16.1_ENST00000581856.1_RNA|DSG4_ENST00000308128.4_Silent_p.I566I|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	566					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AAATCCCAATCCTGGTGAAGG	0.433000													8	25					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	95825586	95825586	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:95825586G>A	ENST00000524717.1	-	2	2893	c.1609C>T	c.(1609-1611)Ctc>Ttc	p.L537F		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	537					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CTTCGACTGAGATCCTGAGGC	0.532000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								11	10					0	0	1	0	0
DDR1	780	broad.mit.edu	37	6	30856766	30856766	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:30856766C>T	ENST00000324771.8	+	5	715	c.167C>T	c.(166-168)tCc>tTc	p.S56F	DDR1_ENST00000376568.3_Missense_Mutation_p.S56F|DDR1_ENST00000376575.3_Missense_Mutation_p.S56F|DDR1_ENST00000452441.1_Missense_Mutation_p.S56F|DDR1_ENST00000454612.2_Missense_Mutation_p.S56F|DDR1_ENST00000376567.2_Missense_Mutation_p.S56F|DDR1_ENST00000376570.4_Missense_Mutation_p.S56F|DDR1_ENST00000508312.1_Missense_Mutation_p.S74F|DDR1_ENST00000376569.3_Missense_Mutation_p.S56F|DDR1_ENST00000446312.1_Missense_Mutation_p.S56F|DDR1_ENST00000418800.2_Missense_Mutation_p.S56F|DDR1_ENST00000513240.1_Missense_Mutation_p.S56F			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	56	F5/8 type C.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	TGGTCAGATTCCACTGCCGCC	0.607000													16	17					0	0	1	0	0
GRAMD2	196996	broad.mit.edu	37	15	72455735	72455735	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:72455735C>T	ENST00000309731.7	-	10	841	c.828G>A	c.(826-828)aaG>aaA	p.K276K	GRAMD2_ENST00000564184.1_5'UTR	NM_001012642.2	NP_001012660.1	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	276						integral to membrane				cervix(2)|endometrium(1)|large_intestine(4)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	13						TCGGCATCTTCTTAGGGCAGG	0.557000													17	50					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166165233	166165233	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:166165233C>T	ENST00000375437.2	+	5	824	c.534C>T	c.(532-534)ggC>ggT	p.G178G	SCN2A_ENST00000283256.6_Silent_p.G178G|SCN2A_ENST00000375427.2_Silent_p.G178G|SCN2A_ENST00000357398.3_Silent_p.G178G	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	178					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TTGCAAGGGGCTTTTGTTTAG	0.323000													27	27					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103338460	103338460	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:103338460C>T	ENST00000428762.1	-	10	1142	c.983G>A	c.(982-984)tGg>tAg	p.W328*	RELN_ENST00000343529.5_Nonsense_Mutation_p.W328*|RELN_ENST00000424685.2_Nonsense_Mutation_p.W328*	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	328					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTCCTGCTTCCACTGAAATTG	0.453000													50	89					0	0	1	0	0
STX11	8676	broad.mit.edu	37	6	144508265	144508265	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:144508265C>T	ENST00000367568.4	+	2	684	c.501C>T	c.(499-501)atC>atT	p.I167I		NM_003764.3	NP_003755.2	O75558	STX11_HUMAN	syntaxin 11	167					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	12				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		AGCTGGAGATCATGGGCAAGG	0.612000									Familial Hemophagocytic Lymphohistiocytosis				10	26					0	0	1	0	0
PRSS12	8492	broad.mit.edu	37	4	119234470	119234470	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:119234470C>T	ENST00000296498.3	-	7	1657	c.1375G>A	c.(1375-1377)Gaa>Aaa	p.E459K		NM_003619.3	NP_003610.2	P56730	NETR_HUMAN	protease, serine, 12 (neurotrypsin, motopsin)	459	SRCR 3.					membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(11)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	29						AATCTGGTTTCCTTTCCTGAG	0.502000													27	37					0	0	1	0	0
ILDR2	387597	broad.mit.edu	37	1	166891994	166891994	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:166891994G>A	ENST00000271417.3	-	8	1102	c.1047C>T	c.(1045-1047)ttC>ttT	p.F349F	ILDR2_ENST00000469934.2_Silent_p.F349F|ILDR2_ENST00000529387.1_Intron|ILDR2_ENST00000529071.1_Silent_p.F330F|ILDR2_ENST00000528703.1_Silent_p.F290F|ILDR2_ENST00000526687.1_Silent_p.F241F|ILDR2_ENST00000525740.1_Silent_p.F222F	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	349						integral to membrane		p.F349F(1)		NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						AAGACTGGCGGAAATTGCTGT	0.488000													48	69					0	0	1	0	0
CSNK1A1	1452	broad.mit.edu	37	5	148891414	148891414	+	Silent	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:148891414T>C	ENST00000261798.5	-	6	1050	c.618A>G	c.(616-618)tcA>tcG	p.S206S	CSNK1A1_ENST00000504676.1_Silent_p.S117S|CSNK1A1_ENST00000377843.2_Silent_p.S206S|CSNK1A1_ENST00000515435.1_Silent_p.S145S|CSNK1A1_ENST00000606299.1_Intron|CSNK1A1_ENST00000606719.1_Silent_p.S3S|CSNK1A1_ENST00000515768.1_Silent_p.S234S	NM_001271741.1	NP_001258670.1	P48729	KC1A_HUMAN	casein kinase 1, alpha 1	206	Protein kinase.				cell division|mitosis|Wnt receptor signaling pathway	centrosome|condensed chromosome kinetochore|cytosol|nuclear speck	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(4)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		CATATCCTAATGATTCCATGT	0.338000													3	38					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116381005	116381005	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:116381005G>A	ENST00000397752.3	+	5	1827	c.1627G>A	c.(1627-1629)Gac>Aac	p.D543N	MET_ENST00000436117.2_Missense_Mutation_p.D543N|MET_ENST00000318493.6_Missense_Mutation_p.D543N|MET_ENST00000495962.1_3'UTR	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	543					axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CTGGTGCCACGACAAATGTGT	0.527000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				16	109					0	0	1	0	0
DNAJC5B	85479	broad.mit.edu	37	8	66992709	66992709	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr8:66992709C>T	ENST00000276570.5	+	5	718	c.431C>T	c.(430-432)tCa>tTa	p.S144L	DNAJC5B_ENST00000519330.1_3'UTR	NM_033105.4	NP_149096.2	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	144					protein folding	membrane	heat shock protein binding|unfolded protein binding			endometrium(3)|large_intestine(6)|liver(1)|lung(6)|prostate(1)|skin(3)	20		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			CGGCCCGAGTCATCAGTGCCA	0.557000													18	17					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21706454	21706454	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:21706454G>A	ENST00000281523.2	-	2	607	c.89C>T	c.(88-90)tCg>tTg	p.S30L	ZNF385D_ENST00000494118.1_Intron	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	30						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						AATATCCAGCGATGGTTGCAA	0.517000													7	22					0	0	1	0	0
PAX4	5078	broad.mit.edu	37	7	127255464	127255464	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:127255464C>T	ENST00000341640.2	-	1	316	c.111G>A	c.(109-111)cgG>cgA	p.R37R	PAX4_ENST00000463946.1_5'UTR|PAX4_ENST00000338516.3_Silent_p.R45R|PAX4_ENST00000378740.2_Silent_p.R37R	NM_006193.2	NP_006184.2	O43316	PAX4_HUMAN	paired box 4	45	Paired.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						CCTTAAGGATCCGTGAGATGT	0.597000													41	71					0	0	1	0	0
DYRK3	8444	broad.mit.edu	37	1	206821195	206821195	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:206821195G>A	ENST00000367106.1	+	4	1065	c.592G>A	c.(592-594)Ggg>Agg	p.G198R	DYRK3_ENST00000367108.3_Missense_Mutation_p.G198R|DYRK3_ENST00000489878.1_Intron|DYRK3_ENST00000367109.2_Missense_Mutation_p.G218R			O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	218					erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			TATTGGCAAGGGGAGTTTTGG	0.478000													18	38					0	0	1	0	0
PLD1	5337	broad.mit.edu	37	3	171379852	171379852	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:171379852C>T	ENST00000356327.5	-	19	2294	c.2224G>A	c.(2224-2226)Gaa>Aaa	p.E742K	PLD1_ENST00000342215.6_3'UTR|PLD1_ENST00000351298.4_Missense_Mutation_p.E780K|PLD1_ENST00000340989.4_Missense_Mutation_p.E780K	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	780	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	AGACTTACTTCGATATAGATA	0.438000													5	8					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	93979370	93979370	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:93979370C>T	ENST00000369303.4	-	7	1642	c.1458G>A	c.(1456-1458)agG>agA	p.R486R		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	486	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		AGGTCCGTTCCCTTTGATCCT	0.358000													10	33					0	0	1	0	0
TDRD10	126668	broad.mit.edu	37	1	154516517	154516517	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:154516517G>A	ENST00000368482.4	+	9	1420	c.582G>A	c.(580-582)ggG>ggA	p.G194G	TDRD10_ENST00000368480.3_Silent_p.G194G|TDRD10_ENST00000479937.1_3'UTR	NM_001098475.1|NM_182499.3	NP_001091945.1|NP_872305.3	Q5VZ19	TDR10_HUMAN	tudor domain containing 10	194							nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCGTCCGTGGGGAGGCGGGGC	0.622000													17	101					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118771480	118771480	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:118771480G>A	ENST00000334801.3	-	6	3936	c.2972C>T	c.(2971-2973)tCg>tTg	p.S991L	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	991	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		CCTGCTGGGCGAGCCAGTGGG	0.652000													22	20					0	0	1	0	0
AHR	196	broad.mit.edu	37	7	17349707	17349707	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:17349707G>T	ENST00000242057.4	+	2	856	c.213G>T	c.(211-213)agG>agT	p.R71S		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	71	Helix-loop-helix motif.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					CAGTTCTTAGGCTCAGCGTCA	0.398000													16	30					3.41278e-10	3.45099e-10	1	1	0
TMCO5A	145942	broad.mit.edu	37	15	38229547	38229547	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:38229547G>A	ENST00000558158.1	+	5	419	c.264_splice	c.e5-1	p.E89_splice	TMCO5A_ENST00000540944.1_Splice_Site_p.E89_splice|TMCO5A_ENST00000319669.4_Splice_Site_p.E89_splice|TMCO5A_ENST00000559502.1_Splice_Site_p.E89_splice			Q8N6Q1	TMC5A_HUMAN	transmembrane and coiled-coil domains 5A	89						integral to membrane				central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	15						TCTCTCACAGGAAAGGAAGAA	0.438000													13	21					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143747584	143747584	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr7:143747584C>T	ENST00000408906.2	+	1	124	c.90C>T	c.(88-90)ttC>ttT	p.F30F		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					CTGGGCTTTTCTCCCTGTTAT	0.512000													47	50					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101375063	101375063	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:101375063C>T	ENST00000344327.3	-	2	1061	c.637G>A	c.(637-639)Ggg>Agg	p.G213R	TRPC6_ENST00000532133.1_Missense_Mutation_p.G213R|TRPC6_ENST00000348423.4_Missense_Mutation_p.G213R|TRPC6_ENST00000360497.4_Missense_Mutation_p.G213R	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	213					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		AACCGTGTCCCATCTTCATCA	0.488000													15	12					0	0	1	0	0
HLA-DRA	3122	broad.mit.edu	37	6	32411162	32411162	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:32411162C>T	ENST00000395388.2	+	3	638	c.529C>T	c.(529-531)Ccc>Tcc	p.P177S	HLA-DRA_ENST00000374982.5_Missense_Mutation_p.P152S	NM_019111.4	NP_061984.2	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR alpha	177	Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	19						CCACTATCTCCCCTTCCTGCC	0.542000									T-cell Lymphoma, (Cutaneous) , Familial Clustering of;Kaposi Sarcoma, Familial Clustering of				49	21					0	0	1	0	0
FAM19A2	338811	broad.mit.edu	37	12	62147517	62147517	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:62147517C>T	ENST00000416284.3	-	4	1854	c.270G>A	c.(268-270)gtG>gtA	p.V90V	FAM19A2_ENST00000550003.1_5'UTR|FAM19A2_ENST00000551619.1_Silent_p.V90V|FAM19A2_ENST00000551449.1_Intron	NM_178539.4	NP_848634.1	Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A2	90						cytoplasm				endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	15			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		ATTTCTGTTCCACTATTGAAG	0.388000													33	37					0	0	1	0	0
STAT5B	6777	broad.mit.edu	37	17	40354389	40354389	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:40354389G>A	ENST00000293328.3	-	18	2374	c.2206C>T	c.(2206-2208)Ccc>Tcc	p.P736S		NM_012448.3	NP_036580.2	P51692	STA5B_HUMAN	signal transducer and activator of transcription 5B	736					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	TGAGCCTGGGGACACACAGCT	0.617000													24	16					0	0	1	0	0
EXOC6B	23233	broad.mit.edu	37	2	72719533	72719533	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:72719533G>A	ENST00000272427.6	-	16	1709	c.1579C>T	c.(1579-1581)Cgg>Tgg	p.R527W	EXOC6B_ENST00000410104.1_Missense_Mutation_p.R527W	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	527					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						GTTGATTTCCGAATCATGTCA	0.413000													33	24					0	0	1	0	0
GABRG2	2566	broad.mit.edu	37	5	161580234	161580234	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:161580234G>A	ENST00000356592.3	+	10	1748	c.1288G>A	c.(1288-1290)Gaa>Aaa	p.E430K	GABRG2_ENST00000361925.4_Missense_Mutation_p.E422K|GABRG2_ENST00000393933.4_Missense_Mutation_p.E327K|GABRG2_ENST00000414552.2_Missense_Mutation_p.E470K	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	422	Interaction with GABARAP (Potential).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding	p.E430*(1)		NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CTGCTGTTTTGAAGATTGTCG	0.468000													32	6					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701340	56701340	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:56701340G>A	ENST00000586855.2	-	5	1657	c.1344C>T	c.(1342-1344)ttC>ttT	p.F448F	ZSCAN5B_ENST00000358992.3_Silent_p.F448F			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	448					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						CCTTGTGGCTGAAAACTTTGC	0.552000													8	22					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43527730	43527730	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:43527730C>T	ENST00000220420.5	-	10	1658	c.1651G>A	c.(1651-1653)Gat>Aat	p.D551N	TGM5_ENST00000349114.4_Missense_Mutation_p.D469N	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	551					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	GGGCTGCCATCGTGCAGCAGA	0.537000													8	22					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63156455	63156455	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:63156455C>T	ENST00000449996.3	+	4	382	c.310C>T	c.(310-312)Cag>Tag	p.Q104*	RGS9_ENST00000577186.1_3'UTR|RGS9_ENST00000443584.3_Nonsense_Mutation_p.Q104*|RGS9_ENST00000262406.9_Nonsense_Mutation_p.Q104*	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	104	DEP.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						CTACAGATTTCAGGTGAGTCT	0.463000													18	30					0	0	1	0	0
SGCG	6445	broad.mit.edu	37	13	23778001	23778001	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:23778001G>A	ENST00000218867.3	+	2	292	c.168G>A	c.(166-168)tgG>tgA	p.W56*	SGCG_ENST00000545013.1_Nonsense_Mutation_p.W56*|SGCG_ENST00000537476.1_Nonsense_Mutation_p.W56*	NM_000231.2	NP_000222.1	Q13326	SGCG_HUMAN	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	56					cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma				NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(29;4.34e-23)|all_epithelial(30;4.4e-19)|all_lung(29;2.45e-18)|Lung SC(185;0.0228)|Breast(139;0.188)		all cancers(112;0.00255)|Epithelial(112;0.0129)|OV - Ovarian serous cystadenocarcinoma(117;0.0365)|Lung(94;0.205)		TTACAATTTGGATTCTTAAAG	0.343000													26	24					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38690731	38690731	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:38690731C>T	ENST00000449981.2	+	2	255	c.146C>T	c.(145-147)cCt>cTt	p.P49L						dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GGTTTCTCTCCTTCCGCAGAA	0.552000													8	34					0	0	1	0	0
KRT71	112802	broad.mit.edu	37	12	52946636	52946636	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:52946636C>T	ENST00000267119.5	-	1	295	c.226G>A	c.(226-228)Gcc>Acc	p.A76T		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	76	Gly-rich.|Head.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		AAGCCACTGGCCCGGCCCCGG	0.632000													4	146					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111025246	111025246	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:111025246G>A	ENST00000262839.2	-	8	2935	c.2017C>T	c.(2017-2019)Ctt>Ttt	p.L673F		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	673					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CAGTTACCAAGGTATAGAAAT	0.463000													59	81					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41012742	41012742	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:41012742G>A	ENST00000399564.4	-	30	3528	c.3078C>T	c.(3076-3078)gcC>gcT	p.A1026A	MROH2B_ENST00000506092.2_Silent_p.A581A	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		ATATGCCACAGGCCTTTGTAC	0.453000													19	32					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13793757	13793757	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:13793757G>A	ENST00000265104.4	-	49	8195	c.8091C>T	c.(8089-8091)atC>atT	p.I2697I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2697	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGATGTCCACGATGCTGGTGA	0.448000									Kartagener syndrome				23	74					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137814764	137814764	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:137814764C>T	ENST00000409968.1	+	3	1092	c.914C>T	c.(913-915)tCg>tTg	p.S305L	THSD7B_ENST00000543459.1_Missense_Mutation_p.S164L|THSD7B_ENST00000413152.2_Missense_Mutation_p.S274L|THSD7B_ENST00000272643.3_Missense_Mutation_p.S305L					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CGGCAGGTTTCGTGTACAAGA	0.363000													10	13					0	0	1	0	0
OR52L1	338751	broad.mit.edu	37	11	6007457	6007457	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:6007457G>A	ENST00000332249.4	-	1	758	c.704C>T	c.(703-705)tCc>tTc	p.S235F		NM_001005173.2	NP_001005173.2	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L, member 1	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|pancreas(1)|skin(3)|soft_tissue(1)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGGGCATAGGAAACACCAAT	0.517000													26	37					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10720328	10720328	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:10720328G>A	ENST00000377022.3	-	6	1088	c.771C>T	c.(769-771)ccC>ccT	p.P257P	CASZ1_ENST00000344008.5_Silent_p.P257P	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	257					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TCTTGGTGCTGGGGGCCGGCC	0.682000													12	52					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160825821	160825821	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr2:160825821C>T	ENST00000283243.7	-	19	2916	c.2710G>A	c.(2710-2712)Gaa>Aaa	p.E904K	PLA2R1_ENST00000392771.1_Missense_Mutation_p.E904K	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	904	C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						ACAGTTCTTTCTCTTCCTGTG	0.373000													26	34					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059273	9059273	+	Silent	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:9059273G>A	ENST00000397910.4	-	3	28376	c.28173C>T	c.(28171-28173)tcC>tcT	p.S9391S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9393	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTCCTGGCCAGGAGGCTGTGC	0.537000													39	37					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24924051	24924051	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:24924051A>G	ENST00000329468.2	+	1	3511	c.3037A>G	c.(3037-3039)Acc>Gcc	p.T1013A		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GGGACCTGGAACCCCTATGGA	0.522000													8	26					0	0	1	0	0
AZI1	22994	broad.mit.edu	37	17	79177318	79177318	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr17:79177318G>A	ENST00000269392.4	-	6	852	c.605C>T	c.(604-606)tCc>tTc	p.S202F	AZI1_ENST00000374782.3_Missense_Mutation_p.S202F|AZI1_ENST00000570482.2_5'UTR|AZI1_ENST00000575907.1_Missense_Mutation_p.S202F|AZI1_ENST00000450824.2_Missense_Mutation_p.S202F	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	202					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			AGTCTGGTTGGAGCTCTTGAG	0.657000													3	5					0	0	1	0	0
ATP7A	538	broad.mit.edu	37	X	77301985	77301985	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chrX:77301985T>A	ENST00000341514.6	+	23	4576	c.4421T>A	c.(4420-4422)cTa>cAa	p.L1474Q	ATP7A_ENST00000350425.4_Missense_Mutation_p.L477Q|ATP7A_ENST00000343533.5_Missense_Mutation_p.L1396Q	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1474					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						AAACGCTCCCTAAACAGTGTT	0.448000													47	166					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76754683	76754683	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr18:76754683G>A	ENST00000536229.3	+	1	3002	c.2293G>A	c.(2293-2295)Gag>Aag	p.E765K	SALL3_ENST00000575389.2_Missense_Mutation_p.E898K|SALL3_ENST00000537592.2_Missense_Mutation_p.E898K			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	898					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CGCCCTGTCCGAGTCCTCGTC	0.726000													14	19					0	0	1	0	0
TMEM201	199953	broad.mit.edu	37	1	9662213	9662213	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:9662213C>T	ENST00000340305.5	+	6	1052	c.1043C>T	c.(1042-1044)tCg>tTg	p.S348L	TMEM201_ENST00000340381.6_Missense_Mutation_p.S348L|TMEM201_ENST00000377376.4_Missense_Mutation_p.S348L	NM_001010866.3	NP_001010866.1	Q5SNT2	TM201_HUMAN	transmembrane protein 201	348						integral to membrane|nuclear inner membrane				lung(3)|upper_aerodigestive_tract(1)	4	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		CAGGCCGCCTCGCCTAGCTGG	0.647000													33	17					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152326311	152326311	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:152326311C>T	ENST00000388718.5	-	3	4023	c.3951G>A	c.(3949-3951)caG>caA	p.Q1317Q	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1317							calcium ion binding|structural molecule activity	p.Q1317Q(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TATCTCCTCTCTGTCCATGAG	0.473000													77	105					0	0	1	0	0
BTBD1	53339	broad.mit.edu	37	15	83686847	83686847	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr15:83686847T>C	ENST00000261721.4	-	8	1623	c.1421A>G	c.(1420-1422)cAa>cGa	p.Q474R	RP11-382A20.5_ENST00000566841.1_RNA|RP11-382A20.7_ENST00000570202.1_RNA|BTBD1_ENST00000379403.2_3'UTR	NM_001011885.1|NM_025238.3	NP_001011885.1|NP_079514.1	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1	474						cytoplasmic mRNA processing body|protein complex	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)	10				all cancers(203;0.000186)		TTCTGGAATTTGTCCATCTTC	0.318000													17	8					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29599806	29599806	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr13:29599806G>A	ENST00000431530.3	+	1	1059	c.1001G>A	c.(1000-1002)gGa>gAa	p.G334E		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	324						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GAACAGGAGGGAAAGGCAGCC	0.532000													13	11					0	0	1	0	0
PDPK2P	653650	broad.mit.edu	37	16	2692083	2692083	+	RNA	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr16:2692083C>T	ENST00000382326.1	-	0	1068																											AAGTGGCCTTCACAACAGGTG	0.557000													3	0					0	0	1	0	0
MS4A14	84689	broad.mit.edu	37	11	60164170	60164170	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:60164170G>A	ENST00000300187.6	+	1	396	c.119G>A	c.(118-120)gGa>gAa	p.G40E	MS4A14_ENST00000531787.1_Intron|MS4A14_ENST00000531783.1_Missense_Mutation_p.G40E|MS4A14_ENST00000395005.2_Missense_Mutation_p.G40E|MS4A14_ENST00000395001.1_5'UTR	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	40						integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						TTTCTGAAGGGAGAGCCAAGA	0.438000													4	12					0	0	1	0	0
MORN5	254956	broad.mit.edu	37	9	124929050	124929050	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr9:124929050G>A	ENST00000536616.1	+	2	89	c.51G>A	c.(49-51)atG>atA	p.M17I	MORN5_ENST00000486801.1_3'UTR|MORN5_ENST00000373764.3_Missense_Mutation_p.M17I			Q5VZ52	MORN5_HUMAN	MORN repeat containing 5	17										endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	9						TTTACAGGATGGAGGGCAAAG	0.532000													6	1					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332563	70332563	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:70332563C>T	ENST00000338508.4	-	32	3837	c.3838G>A	c.(3838-3840)Gag>Aag	p.E1280K	SHANK2_ENST00000409161.1_Missense_Mutation_p.E683K|SHANK2_ENST00000423696.2_Missense_Mutation_p.E900K|SHANK2_ENST00000449833.2_Missense_Mutation_p.E684K			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	900					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TACTTGTTCTCCGTCTCCTGC	0.592000													23	32					0	0	1	0	0
IGHV1-3	28473	broad.mit.edu	37	14	106471673	106471673	+	RNA	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr14:106471673C>T	ENST00000390595.2	-	0	50																											TCCTCCAGGTCCAGTCCATGG	0.547000													19	2					0	0	1	0	0
XPNPEP3	63929	broad.mit.edu	37	22	41318390	41318390	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr22:41318390A>G	ENST00000357137.4	+	8	1193	c.1109A>G	c.(1108-1110)gAt>gGt	p.D370G	XPNPEP3_ENST00000544094.1_Missense_Mutation_p.D347G	NM_022098.3	NP_071381.1	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3, putative	370					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	17						ATCCAAAGAGATTGTTTGGCC	0.473000													111	87					0	0	1	0	0
OR5K4	403278	broad.mit.edu	37	3	98072733	98072733	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:98072733C>T	ENST00000354924.2	+	1	36	c.36C>T	c.(34-36)ttC>ttT	p.F12F	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005517.1	NP_001005517.1	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K, member 4	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	21						CAGCTGAATTCATCCTCATAG	0.418000													14	42					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22820480	22820480	+	RNA	SNP	C	C	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:22820480C>A	ENST00000511446.1	+	0	1347				GBA3_ENST00000508166.1_RNA|GBA3_ENST00000508264.1_RNA|GBA3_ENST00000503442.1_RNA	NM_001277225.1	NP_001264154.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GACCCCGAGTCCCTTACACAT	0.502000													17	6					1.33834e-09	1.35206e-09	1	1	0
FANCD2	2177	broad.mit.edu	37	3	10136044	10136044	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:10136044C>T	ENST00000287647.3	+	40	4053	c.3960C>T	c.(3958-3960)caC>caT	p.H1320H	FANCD2_ENST00000419585.1_Silent_p.H1320H|FANCD2_ENST00000383807.1_Silent_p.H1320H|FANCD2_ENST00000383806.1_3'UTR|FANCD2OS_ENST00000524279.1_Intron|FANCD2OS_ENST00000436517.1_Intron	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	1320					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TTAGAAAACACCGGGTAAGAG	0.468000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				101	77					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152748803	152748803	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:152748803C>T	ENST00000367253.4	-	36	5124	c.5125G>A	c.(5125-5127)Gga>Aga	p.G1709R	SYNE1_ENST00000341594.5_Intron|SYNE1_ENST00000265368.4_Intron|SYNE1_ENST00000423061.1_Intron|SYNE1_ENST00000367255.5_Intron|SYNE1_ENST00000448038.1_Intron			Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5381					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTATTTTTTCCTTCCTCACAC	0.353000										HNSCC(10;0.0054)			20	21					0	0	1	0	0
LSM11	134353	broad.mit.edu	37	5	157181871	157181871	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:157181871C>T	ENST00000286307.5	+	4	738	c.682C>T	c.(682-684)Cgg>Tgg	p.R228W		NM_173491.2	NP_775762.1	P83369	LSM11_HUMAN	LSM11, U7 small nuclear RNA associated	228					histone mRNA 3'-end processing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	histone pre-mRNA 3'end processing complex|nucleoplasm|U7 snRNP	protein binding|U7 snRNA binding			breast(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)	7	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCTATTTGATCGGCTGAAACT	0.363000													11	3					0	0	1	0	0
GZMA	3001	broad.mit.edu	37	5	54405998	54405998	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr5:54405998G>C	ENST00000274306.6	+	5	812	c.777G>C	c.(775-777)aaG>aaC	p.K259N		NM_006144.3	NP_006135.1	P12544	GRAA_HUMAN	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	259	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	25		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				TGACTATCAAGGGAGCAGTTT	0.378000													14	42					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31374421	31374421	+	Silent	SNP	C	C	T			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr20:31374421C>T	ENST00000328111.2	+	5	741	c.420C>T	c.(418-420)ttC>ttT	p.F140F	DNMT3B_ENST00000344505.4_Silent_p.F140F|DNMT3B_ENST00000353855.2_Silent_p.F140F|DNMT3B_ENST00000456297.2_Intron|DNMT3B_ENST00000443239.3_Intron|DNMT3B_ENST00000348286.2_Silent_p.F140F|DNMT3B_ENST00000375623.4_Intron|DNMT3B_ENST00000201963.3_Silent_p.F152F	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	140	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CCGTGGAGTTCCCGGCTACCA	0.627000													31	34					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113857486	113857486	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr11:113857486G>A	ENST00000355556.2	+	7	1203	c.970G>A	c.(970-972)Gag>Aag	p.E324K	HTR3A_ENST00000504030.2_Intron|HTR3A_ENST00000299961.5_Intron|HTR3A_ENST00000375498.2_Intron|HTR3A_ENST00000506841.2_Missense_Mutation_p.E318K|HTR3A_ENST00000535865.1_Intron	NM_213621.3	NP_998786.2	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	305					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	TCAGTCTGGTGAGAAACCCGC	0.597000													27	25					0	0	1	0	0
PDS5A	23244	broad.mit.edu	37	4	39865006	39865006	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr4:39865006G>A	ENST00000303538.8	-	24	3255	c.2716C>T	c.(2716-2718)Cat>Tat	p.H906Y		NM_001100399.1	NP_001093869.1	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	906					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(14)|prostate(3)|skin(1)|urinary_tract(1)	39						ATAATTTCATGGTAACAAGGT	0.333000													5	14					0	0	1	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155936216	155936216	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr1:155936216delG	ENST00000368316.1	-	8	720	c.250delC	c.(250-252)gafs	p.R84fs	ARHGEF2_ENST00000313667.4_Frame_Shift_Del_p.R111fs|ARHGEF2_ENST00000361247.4_Frame_Shift_Del_p.R111fs|ARHGEF2_ENST00000313695.7_Frame_Shift_Del_p.R84fs|ARHGEF2_ENST00000368315.3_Frame_Shift_Del_p.R112fs			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	111					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					CTCTTACTTCGAAGAGAAACG	0.562													31	45	---	---	---	---					
ATRIP	84126	broad.mit.edu	37	3	48501288	48501289	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr3:48501288_48501289delCC	ENST00000412052.1	+	7	1211_1212	c.749_750delCC	c.(748-750)afs	p.T250fs	ATRIP_ENST00000320211.3_Frame_Shift_Del_p.T343fs|ATRIP_ENST00000346691.4_Frame_Shift_Del_p.T343fs|ATRIP_ENST00000357105.6_Frame_Shift_Del_p.T216fs	NM_001271023.1	NP_001257952.1	Q8WXE1	ATRIP_HUMAN	ATR interacting protein	343					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)	22				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCTGCTGGCACCCCCCTGCAGC	0.535								Other conserved DNA damage response genes					46	56	---	---	---	---					
TNXB	7148	broad.mit.edu	37	6	32017236	32017236	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr6:32017236delG	ENST00000375244.3	-	28	9769	c.9568delC	c.(9568-9570)agfs	p.Q3190fs	TNXB_ENST00000375247.2_Frame_Shift_Del_p.Q3188fs			P22105	TENX_HUMAN	tenascin XB	3235					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						AAGCGGCCCTGGGGGACGGTC	0.692													20	117	---	---	---	---					
OR13C5	138799	broad.mit.edu	37	9	107361451	107361452	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr9:107361451_107361452delGC	ENST00000374779.2	-	1	336_337	c.243_244delGC	c.(241-246)actafs	p.TL81fs		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	81					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						AAGCTCACTAGCGTGGAGGGAA	0.510													3	6	---	---	---	---					
NR4A1	3164	broad.mit.edu	37	12	52448454	52448454	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:52448454delC	ENST00000545748.1	+	3	1499	c.504delC	c.(502-504)ggfs	p.G168fs	NR4A1_ENST00000394824.2_Frame_Shift_Del_p.G114fs|NR4A1_ENST00000394825.1_Frame_Shift_Del_p.G114fs|NR4A1_ENST00000550082.1_Frame_Shift_Del_p.G127fs|NR4A1_ENST00000548232.1_Frame_Shift_Del_p.G114fs|NR4A1_ENST00000547206.1_3'UTR|NR4A1_ENST00000243050.1_Frame_Shift_Del_p.G114fs|NR4A1_ENST00000360284.3_Frame_Shift_Del_p.G127fs			P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	114					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)	16				BRCA - Breast invasive adenocarcinoma(357;0.0967)		GCTACCCCGGCCCCCTGAGCG	0.677													47	89	---	---	---	---					
KNTC1	9735	broad.mit.edu	37	12	123087590	123087591	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr12:123087590_123087591delTG	ENST00000333479.7	+	48	5078_5079	c.4901_4902delTG	c.(4900-4902)cfs	p.L1634fs	KNTC1_ENST00000450485.2_Intron|KNTC1_ENST00000537348.1_Frame_Shift_Del_p.L59fs|KNTC1_ENST00000436959.3_5'UTR	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1634					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CTGGACACTCTGTACGTGTCTA	0.366													2	4	---	---	---	---					
ZNF579	163033	broad.mit.edu	37	19	56089908	56089909	+	In_Frame_Ins	INS	-	-	CCG	rs141478862	by1000genomes	TCGA-FS-A4F5-06A-11D-A25O-08	TCGA-FS-A4F5-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1D84AB9A-8603-4A0D-A250-EEDFCE113241	019F425C-9609-4F27-AB25-EA54BE720545	g.chr19:56089908_56089909insCCG	ENST00000325421.4	-	2	1125_1126	c.1097_1098insCGG	c.(1096-1098)gca>gCGGca	p.366_366A>AA		NM_152600.2	NP_689813.2	Q8NAF0	ZN579_HUMAN	zinc finger protein 579	366	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G366_Q367insG(1)		endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.106)		CTCCGTTCTGCCCTTCTCCCCC	0.748													3	3	---	---	---	---