Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TTN	7273	broad.mit.edu	37	2	179595880	179595880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:179595880C>T	ENST00000589042.1	-	60	17736	c.17512G>A	c.(17512-17514)Gac>Aac	p.D5838N	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D5521N|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.D4594N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5521	Ig-like 39.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGGCTGGGTCTCCTTGGGTG	0.438000													57	127					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233272653	233272653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:233272653G>A	ENST00000295453.3	+	5	626	c.574G>A	c.(574-576)Gac>Aac	p.D192N		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	192					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CTCGGATGCCGACGTGCCTGC	0.662000													34	87					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95186166	95186166	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:95186166C>T	ENST00000027335.3	-	7	766	c.642G>A	c.(640-642)aaG>aaA	p.K214K	CDH17_ENST00000441892.2_Intron|CDH17_ENST00000450165.2_Silent_p.K214K	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	214	Cadherin 2.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CTCCCATGTCCTTCACTGAGA	0.448000													32	46					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152084955	152084955	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:152084955C>T	ENST00000368804.1	-	2	737	c.738G>A	c.(736-738)tgG>tgA	p.W246*		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	246					keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGCGCTTCCTCCACTCTTTCT	0.587000													87	166					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21713345	21713345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:21713345C>T	ENST00000261195.2	-	8	1398	c.1144G>A	c.(1144-1146)Gga>Aga	p.G382R		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	382					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						ACTGCTTGTCCTTTCAGGGTT	0.368000													23	66					0	0	1	0	0
NPIPA1	9284	broad.mit.edu	37	16	15045811	15045811	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr16:15045811C>T	ENST00000328085.6	+	8	982	c.982C>T	c.(982-984)Ctc>Ttc	p.L328F	NPIPA1_ENST00000472413.1_3'UTR	NM_006985.2	NP_008916.2			nuclear pore complex interacting protein family, member A1																		GGATGATAATCTCAAGACACC	0.473000													13	153					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37523022	37523022	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:37523022C>G	ENST00000264741.5	+	4	724	c.468C>G	c.(466-468)atC>atG	p.I156M	ITGA9_ENST00000422441.1_Missense_Mutation_p.I156M	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	156					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		CCGACCACATCCTACCCCATG	0.512000													36	59					0	0	1	0	0
EEA1	8411	broad.mit.edu	37	12	93175731	93175731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:93175731C>T	ENST00000322349.8	-	23	3595	c.3331G>A	c.(3331-3333)Gaa>Aaa	p.E1111K		NM_003566.3	NP_003557.2	Q15075	EEA1_HUMAN	early endosome antigen 1	1111	Glu/Lys-rich.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						AATACCTTTTCTTTCTGAATG	0.398000													19	60					0	0	1	0	0
DHTKD1	55526	broad.mit.edu	37	10	12160760	12160760	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr10:12160760C>T	ENST00000263035.4	+	15	2477	c.2415C>T	c.(2413-2415)ctC>ctT	p.L805L		NM_018706.5	NP_061176.3	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	805					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			TTAAGACCCTCGTGTTCTGCT	0.473000													79	162					0	0	1	0	0
TMEM130	222865	broad.mit.edu	37	7	98460854	98460854	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:98460854C>T	ENST00000339375.4	-	2	429	c.255G>A	c.(253-255)atG>atA	p.M85I	TMEM130_ENST00000546258.1_Missense_Mutation_p.M66I|TMEM130_ENST00000450876.1_Start_Codon_SNP_p.M1I|TMEM130_ENST00000345589.4_Intron|TMEM130_ENST00000416379.2_Missense_Mutation_p.M85I	NM_001134450.1|NM_152913.2	NP_001127922.1|NP_690877.1	Q8N3G9	TM130_HUMAN	transmembrane protein 130	85						Golgi membrane|integral to membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	25	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GACCCTTCTCCATCTTGCCAG	0.657000													16	39					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39288923	39288923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:39288923C>T	ENST00000263408.4	-	10	1642	c.1547G>A	c.(1546-1548)gGa>gAa	p.G516E		NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	516	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			CACTGTACCTCCATTTTGGCA	0.353000													22	64					0	0	1	0	0
MTRR	4552	broad.mit.edu	37	5	7900103	7900103	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:7900103C>T	ENST00000264668.2	+	15	2140	c.2110C>T	c.(2110-2112)Cta>Tta	p.L704L	MTRR_ENST00000440940.2_Silent_p.L677L	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	704					methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	AGTTGAAAAACTAGAAGCAAT	0.343000													36	80					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540327	169540327	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:169540327G>A	ENST00000340806.6	+	1	618	c.618G>A	c.(616-618)gaG>gaA	p.E206E		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	206										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						TCCCAGAAGAGATCGGACACC	0.527000													36	116					0	0	1	0	0
SHISA2	387914	broad.mit.edu	37	13	26621161	26621161	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr13:26621161G>A	ENST00000319420.3	-	2	433	c.378C>T	c.(376-378)gtC>gtT	p.V126V		NM_001007538.1	NP_001007539.1	Q6UWI4	SHSA2_HUMAN	shisa family member 2	126					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)|skin(1)	17						TGATAAAGGCGACAAACACGG	0.542000													12	35					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93815726	93815726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:93815726G>A	ENST00000315765.9	+	10	1867	c.1859G>A	c.(1858-1860)cGa>cAa	p.R620Q		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	620	Plastocyanin-like 4.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				AAATCCAACCGAATGCATGGT	0.353000													3	9					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139193050	139193050	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:139193050C>T	ENST00000274710.3	+	3	733	c.528C>T	c.(526-528)ttC>ttT	p.F176F		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	176					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGTCAGCTTCGAGGCCCCCC	0.657000													22	55					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454420	84454420	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr13:84454420T>C	ENST00000377084.2	-	1	2108	c.1223A>G	c.(1222-1224)aAc>aGc	p.N408S		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	408						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GATGTTATTGTTGCCCAGATC	0.458000													106	187					0	0	1	0	0
IL18R1	8809	broad.mit.edu	37	2	103001445	103001445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:103001445G>A	ENST00000409599.1	+	8	1152	c.796G>A	c.(796-798)Gaa>Aaa	p.E266K	IL18R1_ENST00000233957.1_Missense_Mutation_p.E266K			Q13478	IL18R_HUMAN	interleukin 18 receptor 1	266	Ig-like C2-type 3.				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			breast(1)|endometrium(3)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						TGAAGAGAAAGAAATGAGAAT	0.308000													19	30					0	0	1	0	0
STRC	161497	broad.mit.edu	37	15	43893679	43893679	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr15:43893679C>T	ENST00000450892.2	-	24	4693	c.4616G>A	c.(4615-4617)gGa>gAa	p.G1539E	STRC_ENST00000541030.1_Missense_Mutation_p.G766E	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1539					sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		TTCCCGATCTCCTAGACCTAT	0.552000													18	17					0	0	1	0	0
GPRASP1	9737	broad.mit.edu	37	X	101911016	101911016	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:101911016G>A	ENST00000537097.1	+	6	2988	c.2175G>A	c.(2173-2175)tgG>tgA	p.W725*	GPRASP1_ENST00000361600.5_Nonsense_Mutation_p.W725*|GPRASP1_ENST00000444152.1_Nonsense_Mutation_p.W725*|GPRASP1_ENST00000415986.1_Nonsense_Mutation_p.W725*|RP4-769N13.7_ENST00000602441.1_RNA	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	725	Glu-rich.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						CCTGGTTATGGGCTACAGAAG	0.453000													54	105					0	0	1	0	0
ITPKB	3707	broad.mit.edu	37	1	226924620	226924620	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:226924620G>A	ENST00000429204.1	-	2	867	c.540C>T	c.(538-540)ttC>ttT	p.F180F	ITPKB_ENST00000366784.1_Silent_p.F180F|ITPKB_ENST00000272117.3_Silent_p.F180F	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	180							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				TGCTGCTGCGGAAGGGGCACG	0.672000													35	64					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331687	85331687	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:85331687A>C	ENST00000440886.1	-	1	155	c.117T>G	c.(115-117)ttT>ttG	p.F39L	LPAR3_ENST00000370611.3_Missense_Mutation_p.F39L|LPAR3_ENST00000491034.1_5'UTR			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	39					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						ACAGGCAGAAAAACGTCCCAA	0.378000													42	48					0	0	1	0	0
IGKV1OR2-118	339562	broad.mit.edu	37	2	90458637	90458637	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:90458637A>G	ENST00000603238.1	+	2	313	c.313A>G	c.(313-315)Act>Gct	p.105_105insA																								AGATTTTGCAACTTATTACTG	0.512000													17	848					0	0	1	0	0
FAM194A	131831	broad.mit.edu	37	3	150421589	150421589	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:150421589C>T	ENST00000295910.6	-	1	149	c.97G>A	c.(97-99)Gag>Aag	p.E33K	RP11-103G8.2_ENST00000471093.1_RNA|FAM194A_ENST00000491361.1_5'UTR	NM_152394.3	NP_689607.2	Q7L0X2	F194A_HUMAN	family with sequence similarity 194, member A	33	Glu-rich.									NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						tcctccacctcttcctcctcc	0.627000													9	31					0	0	1	0	0
F2RL2	2151	broad.mit.edu	37	5	75914174	75914174	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:75914174A>T	ENST00000296641.4	-	2	561	c.358T>A	c.(358-360)Ttc>Atc	p.F120I	IQGAP2_ENST00000274364.6_Intron|F2RL2_ENST00000504899.1_Missense_Mutation_p.F98I|IQGAP2_ENST00000379730.3_Intron|IQGAP2_ENST00000502745.1_Intron|IQGAP2_ENST00000396234.3_Intron	NM_004101.3	NP_004092.1	O00254	PAR3_HUMAN	coagulation factor II (thrombin) receptor-like 2	120					platelet activation	extracellular region|integral to plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|thrombin receptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(3)	32		all_lung(232;0.000462)|Lung NSC(167;0.00124)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)		GTCCTGAAGAAAAGCATCCAC	0.453000													24	55					0	0	1	0	0
FGFR1	2260	broad.mit.edu	37	8	38275492	38275492	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:38275492G>A	ENST00000447712.2	-	11	2389	c.1448C>T	c.(1447-1449)cCc>cTc	p.P483L	FGFR1_ENST00000397103.1_Missense_Mutation_p.P394L|FGFR1_ENST00000397108.4_Missense_Mutation_p.P481L|FGFR1_ENST00000532791.1_Missense_Mutation_p.P481L|FGFR1_ENST00000397091.5_Missense_Mutation_p.P481L|FGFR1_ENST00000397113.2_Missense_Mutation_p.P481L|FGFR1_ENST00000356207.5_Missense_Mutation_p.P394L|FGFR1_ENST00000341462.5_Missense_Mutation_p.P483L|FGFR1_ENST00000335922.5_Missense_Mutation_p.P473L|FGFR1_ENST00000326324.6_Missense_Mutation_p.P392L|FGFR1_ENST00000425967.3_Missense_Mutation_p.P514L	NM_001174063.1|NM_015850.3|NM_023110.2	NP_001167534.1|NP_056934.2|NP_075598.2	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1	483	Protein kinase.				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity		FGFR1/ZNF703(2)	breast(2)|central_nervous_system(7)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(18)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	50	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	CTCTCCCAGGGGTTTGCCTAA	0.552000		1	T	"""BCR, FOP, ZNF198, CEP1"""	"""MPD, NHL"""		"""Pfeiffer syndrome, Kallman syndrome"""						23	54					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196311248	196311248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:196311248C>T	ENST00000367433.5	-	15	1615	c.1514G>A	c.(1513-1515)gGa>gAa	p.G505E	KCNT2_ENST00000367431.4_Intron|KCNT2_ENST00000451324.2_Missense_Mutation_p.G116E|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000294725.8_Missense_Mutation_p.G505E			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	505	RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						AAAACTCTTTCCTTCATATTC	0.363000													16	23					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64556386	64556386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:64556386C>T	ENST00000357395.3	+	60	12064	c.920C>T	c.(919-921)tCa>tTa	p.S307L	ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000358025.3_Missense_Mutation_p.S3922L|SYNE2_ENST00000394768.2_Missense_Mutation_p.S307L|SYNE2_ENST00000554584.1_Missense_Mutation_p.S3955L|SYNE2_ENST00000344113.4_Missense_Mutation_p.S3922L|SYNE2_ENST00000555002.1_Missense_Mutation_p.S556L			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3922					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTTGATTTTTCACCTGAAGAA	0.254000													10	26					0	0	1	0	0
NCF4	4689	broad.mit.edu	37	22	37271770	37271770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:37271770G>A	ENST00000397147.4	+	8	887	c.703G>A	c.(703-705)Gac>Aac	p.D235N	NCF4_ENST00000248899.6_Missense_Mutation_p.D235N	NM_013416.3	NP_038202.2	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4, 40kDa	235					cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			cervix(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						TGAGGAGGACGACCCCACCAA	0.597000													34	87					0	0	1	0	0
MSH4	4438	broad.mit.edu	37	1	76355048	76355048	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:76355048G>A	ENST00000263187.3	+	16	2324	c.2220G>A	c.(2218-2220)atG>atA	p.M740I		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	740					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						TGAAAGAAATGAAAGAGGTAC	0.269000								Mismatch excision repair (MMR)					17	23					0	0	1	0	0
INHBE	83729	broad.mit.edu	37	12	57849380	57849380	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:57849380G>A	ENST00000266646.2	+	1	277	c.61G>A	c.(61-63)Ggg>Agg	p.G21R	INHBE_ENST00000551553.1_Intron	NM_031479.3	NP_113667.1	P58166	INHBE_HUMAN	inhibin, beta E	21					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	15						GCGAGCACAGGGGACAGGGTC	0.632000													7	29					0	0	1	0	0
MECP2	4204	broad.mit.edu	37	X	153296195	153296195	+	Missense_Mutation	SNP	G	G	A	rs62643611		TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:153296195G>A	ENST00000303391.6	-	4	1333	c.1084C>T	c.(1084-1086)Ccc>Tcc	p.P362S	MECP2_ENST00000453960.2_Missense_Mutation_p.P374S	NM_004992.3	NP_004983.1	P51608	MECP2_HUMAN	methyl CpG binding protein 2 (Rett syndrome)	362					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity			breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|prostate(2)|urinary_tract(1)	23	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCTTCTTGGGGGGTGAGGAG	0.657000													28	40					0	0	1	0	0
TMEM184A	202915	broad.mit.edu	37	7	1594938	1594938	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:1594938G>A	ENST00000297477.5	-	2	499	c.183C>T	c.(181-183)atC>atT	p.I61I		NM_001097620.1	NP_001091089.1	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	61						integral to membrane				endometrium(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		TCCACACGAAGATCCCCGAGA	0.682000													10	35					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35733382	35733382	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr13:35733382G>A	ENST00000540320.1	+	22	3608	c.3074G>A	c.(3073-3075)cGa>cAa	p.R1025Q	NBEA_ENST00000400445.3_Missense_Mutation_p.R1025Q|NBEA_ENST00000379939.2_Missense_Mutation_p.R1025Q|NBEA_ENST00000310336.4_Missense_Mutation_p.R1025Q			Q8NFP9	NBEA_HUMAN	neurobeachin	1025						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ACAGATACTCGAGACTTACTC	0.413000													21	50					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38648282	38648282	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:38648282G>A	ENST00000413689.1	-	9	1211	c.1018C>T	c.(1018-1020)Cgg>Tgg	p.R340W	SCN5A_ENST00000425664.1_Missense_Mutation_p.R340W|SCN5A_ENST00000443581.1_Missense_Mutation_p.R340W|SCN5A_ENST00000414099.2_Missense_Mutation_p.R340W|SCN5A_ENST00000423572.2_Missense_Mutation_p.R340W|SCN5A_ENST00000449557.2_Missense_Mutation_p.R340W|SCN5A_ENST00000450102.2_Missense_Mutation_p.R340W|SCN5A_ENST00000455624.2_Missense_Mutation_p.R340W|SCN5A_ENST00000333535.4_Missense_Mutation_p.R340W|SCN5A_ENST00000451551.2_Missense_Mutation_p.R340W	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	340					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TTTAGGCACCGGTAGCCCTCC	0.602000													23	37					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118199091	118199091	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:118199091C>T	ENST00000425217.1	-	4	678	c.624G>A	c.(622-624)ccG>ccA	p.P208P	KSR2_ENST00000339824.5_Silent_p.P237P	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	237	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTGGCGGGGGCGGGCACAAGC	0.721000													17	37					0	0	1	0	0
MEGF11	84465	broad.mit.edu	37	15	66215174	66215174	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr15:66215174G>A	ENST00000409699.2	-	14	1981	c.1809C>T	c.(1807-1809)ccC>ccT	p.P603P	MEGF11_ENST00000288745.3_Silent_p.P528P|MEGF11_ENST00000360698.4_Silent_p.P603P|MEGF11_ENST00000395614.1_5'UTR|MEGF11_ENST00000395625.2_Silent_p.P528P|MEGF11_ENST00000422354.1_Silent_p.P603P			A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11	603	EGF-like 10.					basolateral plasma membrane|integral to membrane				breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	19						TCTGGCATAAGGGTCCTCGGA	0.607000													3	16					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57405110	57405110	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:57405110C>T	ENST00000374900.4	+	6	889	c.769C>T	c.(769-771)Ccc>Tcc	p.P257S		NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	257						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						AGGTCAGTTTCCCTTGGCTGT	0.507000										HNSCC(52;0.14)			6	70					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140235981	140235981	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:140235981C>T	ENST00000307360.5	+	1	348	c.348C>T	c.(346-348)ttC>ttT	p.F116F	PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Silent_p.F116F|PCDHA3_ENST00000522353.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGGTTTTCCATGTGGACG	0.547000													82	145					0	0	1	0	0
RP11-565P22.6	0	broad.mit.edu	37	1	162351853	162351853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:162351853G>A	ENST00000431696.1	+	3	489	c.489G>A	c.(487-489)ctG>ctA	p.163_163insL	C1orf226_ENST00000458626.2_Silent_p.L54L|C1orf226_ENST00000426197.2_Silent_p.L97L																							TCAAGAACCTGGGCAAAGCCA	0.632000													6	9					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6457906	6457906	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:6457906G>A	ENST00000358945.3	-	12	2122	c.1682C>T	c.(1681-1683)tCt>tTt	p.S561F	SCNN1A_ENST00000396966.2_3'UTR|SCNN1A_ENST00000360168.3_Missense_Mutation_p.S598F|SCNN1A_ENST00000543768.1_Missense_Mutation_p.S562F|SCNN1A_ENST00000228916.2_Missense_Mutation_p.S539F|SCNN1A_ENST00000540037.1_Missense_Mutation_p.S239F			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	539					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	GACAGAGGGAGACTCAGAATT	0.522000													32	81					0	0	1	0	0
COX10-AS1	100874058	broad.mit.edu	37	17	13928449	13928449	+	RNA	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:13928449G>A	ENST00000602743.1	-	0	224																											AAGTGGGAGGGAGGGGGTGAC	0.617000													11	24					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	887678	887678	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:887678G>A	ENST00000314167.4	-	8	971	c.861C>T	c.(859-861)gtC>gtT	p.V287V	GAK_ENST00000511163.1_Silent_p.V208V	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	287	Protein kinase.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		GGCTGTGGAAGACCGTGTACT	0.622000													15	40					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158325189	158325189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:158325189G>A	ENST00000444681.2	+	2	451	c.158G>A	c.(157-159)gGa>gAa	p.G53E	CD1E_ENST00000368155.3_Intron|CD1E_ENST00000368156.1_Intron|CD1E_ENST00000368163.3_Missense_Mutation_p.G152E|CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368160.3_Missense_Mutation_p.G152E|CD1E_ENST00000368165.3_Intron|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368161.3_Missense_Mutation_p.G152E|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000434258.1_Missense_Mutation_p.G150E|CD1E_ENST00000368167.3_Missense_Mutation_p.G152E|CD1E_ENST00000368166.3_Intron|CD1E_ENST00000368154.1_Intron	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	152					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					AGTTTCCAAGGAATTTCCTGG	0.458000													23	82					0	0	1	0	0
KIF1C	10749	broad.mit.edu	37	17	4926878	4926878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:4926878C>T	ENST00000320785.5	+	23	3101	c.2744C>T	c.(2743-2745)tCg>tTg	p.S915L		NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	915					microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						CGGCCCCCCTCGCCACCACTG	0.667000													15	51					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955501	18955501	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:18955501G>A	ENST00000302797.3	-	1	1055	c.831C>T	c.(829-831)tcC>tcT	p.S277S		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	277					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GCTGCCTAAAGGAGCCCACGA	0.507000													30	44					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21232149	21232149	+	Missense_Mutation	SNP	C	C	T	rs149358359	byFrequency	TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:21232149C>T	ENST00000233242.1	-	26	7718	c.7591G>A	c.(7591-7593)Gaa>Aaa	p.E2531K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2531					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CGTTGAAGTTCCTGCTGAATG	0.453000													25	28					0	0	1	0	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22473351	22473351	+	RNA	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr15:22473351C>T	ENST00000557788.2	-	0	2																											ACAGGTGTTTCATGTTCTTGT	0.512000													5	75					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41551602	41551602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:41551602C>T	ENST00000396942.1	-	29	3429	c.3346G>A	c.(3346-3348)Gag>Aag	p.E1116K	ANK1_ENST00000396945.1_Missense_Mutation_p.E1116K|ANK1_ENST00000379758.2_Missense_Mutation_p.E1116K|ANK1_ENST00000352337.4_Missense_Mutation_p.E1116K|ANK1_ENST00000265709.8_Missense_Mutation_p.E1157K|ANK1_ENST00000289734.7_Missense_Mutation_p.E1116K|ANK1_ENST00000347528.4_Missense_Mutation_p.E1116K			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1116					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GTGACAAGCTCATCCGGGACA	0.627000													20	26					0	0	1	0	0
PYGM	5837	broad.mit.edu	37	11	64522183	64522183	+	Silent	SNP	G	G	A	rs146289842		TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:64522183G>A	ENST00000164139.3	-	8	1379	c.981C>T	c.(979-981)ttC>ttT	p.F327F	PYGM_ENST00000377432.3_Silent_p.F239F	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	327					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	GGAAGGCATCGAAGTTCGTGC	0.602000													3	23					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173486701	173486701	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:173486701G>A	ENST00000367714.3	-	23	3304	c.2882C>T	c.(2881-2883)aCc>aTc	p.T961I	SLC9C2_ENST00000466087.1_5'UTR	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	961					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										ACAGATGACGGTATATTCAAT	0.358000													29	46					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18436211	18436211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:18436211C>T	ENST00000338745.6	-	7	2683	c.949G>A	c.(949-951)Gtc>Atc	p.V317I	SATB1_ENST00000454909.2_Missense_Mutation_p.V317I|SATB1_ENST00000417717.2_Missense_Mutation_p.V317I|TBC1D5_ENST00000414318.2_Intron	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	317					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						TGCTGGTTGACCAATTGAGGA	0.542000													9	73					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168105256	168105256	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:168105256G>A	ENST00000409195.1	+	9	7443	c.7354G>A	c.(7354-7356)Gat>Aat	p.D2452N	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.D2230N|XIRP2_ENST00000295237.9_Missense_Mutation_p.D2452N|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2277					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CTCCCTGTCAGATATGGAATG	0.413000													37	75					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62041100	62041100	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:62041100G>A	ENST00000435607.1	-	10	1614	c.1538C>T	c.(1537-1539)tCg>tTg	p.S513L	SCN4A_ENST00000578147.1_Missense_Mutation_p.S513L	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	513					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CTCCCCTTGCGATGTGTCCAG	0.647000													6	10					0	0	1	0	0
OR1F1	4992	broad.mit.edu	37	16	3255008	3255008	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr16:3255008C>T	ENST00000304646.2	+	1	762	c.762C>T	c.(760-762)acC>acT	p.T254T	AJ003147.9_ENST00000576468.1_RNA	NM_012360.1	NP_036492.1	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F, member 1	254					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(7)	11						TCTACAGCACCATCATTGCTG	0.498000													42	123					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124533001	124533001	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:124533001C>T	ENST00000408936.3	+	11	2258	c.2076C>T	c.(2074-2076)tcC>tcT	p.S692S	DAB2IP_ENST00000259371.2_Silent_p.S664S|DAB2IP_ENST00000309989.1_Silent_p.S568S			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	692					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						ACGATCTTTCCGGGTAAGAGC	0.577000													13	15					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140969392	140969392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:140969392C>T	ENST00000298296.1	+	4	719	c.719C>T	c.(718-720)tCc>tTc	p.S240F	MAGEC3_ENST00000443323.2_Intron|MAGEC3_ENST00000536088.1_Intron|MAGEC3_ENST00000448920.1_Intron	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	240	MAGE 1.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					TTTGGCATTTCCCTGACAGAA	0.473000													64	120					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152432772	152432772	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:152432772A>T	ENST00000427231.2	-	106	17003	c.16801T>A	c.(16801-16803)Ttt>Att	p.F5601I	NEB_ENST00000604864.1_Missense_Mutation_p.F5601I|NEB_ENST00000409198.1_Missense_Mutation_p.F3900I|NEB_ENST00000603639.1_Missense_Mutation_p.F5601I|NEB_ENST00000172853.10_Missense_Mutation_p.F3900I|NEB_ENST00000397345.3_Missense_Mutation_p.F5601I	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	5612					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTGTCACAAAAGATATTCTGG	0.478000													31	60					0	0	1	0	0
TRBV4-2	28616	broad.mit.edu	37	7	142045530	142045530	+	RNA	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:142045530G>A	ENST00000390392.3	+	0	169																											AGTCCCCATGGAAACGGGAGT	0.473000													26	99					0	0	1	0	0
FBXW12	285231	broad.mit.edu	37	3	48436111	48436111	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:48436111C>T	ENST00000296438.5	+	11	1568	c.1382C>T	c.(1381-1383)tCt>tTt	p.S461F	FBXW12_ENST00000436231.1_Missense_Mutation_p.S304F|FBXW12_ENST00000468158.1_Intron|FBXW12_ENST00000415155.1_Missense_Mutation_p.S391F|FBXW12_ENST00000445170.1_Missense_Mutation_p.S442F	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	461										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTGATGTATTCTTTGAATACG	0.363000													18	21					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	4046014	4046014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:4046014G>A	ENST00000381638.2	-	1	300	c.176C>T	c.(175-177)gCt>gTt	p.A59V	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	59							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						CGCTGCAGCAGCCTCTCGCAG	0.756000													4	9					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229505	140229505	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:140229505C>T	ENST00000378122.3	+	1	2149	c.1425C>T	c.(1423-1425)ttC>ttT	p.F475F	PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA9_ENST00000532602.1_Silent_p.F475F|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA8_ENST00000531613.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCACATCTTCACGGTGTCTG	0.657000													61	98					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								5	55					0	0	1	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220387315	220387315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:220387315C>T	ENST00000358951.2	-	3	303	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K		NM_012414.3	NP_036546.2	Q9H2M9	RBGPR_HUMAN	RAB3 GTPase activating protein subunit 2 (non-catalytic)	63					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(131;0.0443)		GTATTTCCTTCTTCTTCCTGT	0.383000													6	15					0	0	1	0	0
IPO8	10526	broad.mit.edu	37	12	30784923	30784923	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:30784923G>A	ENST00000256079.4	-	24	3260	c.2922C>T	c.(2920-2922)gcC>gcT	p.A974A	IPO8_ENST00000544829.1_Silent_p.A769A	NM_006390.3	NP_006381.2	O15397	IPO8_HUMAN	importin 8	974					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(16)|liver(1)|lung(22)|prostate(2)|skin(2)|urinary_tract(2)	52	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GCTGGTACCAGGCTGCATCTC	0.522000													10	18					0	0	1	0	0
ZNF426	79088	broad.mit.edu	37	19	9639548	9639548	+	Silent	SNP	A	A	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:9639548A>G	ENST00000593003.1	-	6	1536	c.1059T>C	c.(1057-1059)ccT>ccC	p.P353P	ZNF426_ENST00000253115.2_Silent_p.P391P|ZNF426_ENST00000535489.1_Silent_p.P391P			Q9BUY5	ZN426_HUMAN	zinc finger protein 426	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20						CACATACAAAAGGCTTCTCTC	0.418000													20	22					0	0	1	0	0
KIAA0586	9786	broad.mit.edu	37	14	58955410	58955410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:58955410C>T	ENST00000423743.3	+	25	3725	c.3467C>T	c.(3466-3468)cCa>cTa	p.P1156L	KIAA0586_ENST00000538571.2_3'UTR|KIAA0586_ENST00000261244.5_Missense_Mutation_p.P1124L|KIAA0586_ENST00000556134.1_Missense_Mutation_p.P1185L|KIAA0586_ENST00000354386.6_Missense_Mutation_p.P1253L	NM_001244191.1|NM_001244192.1	NP_001231120.1|NP_001231121.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	1124										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CCTCCAGAGCCAGTTCCCTTT	0.483000													17	43					0	0	1	0	0
SDCCAG3	10807	broad.mit.edu	37	9	139299544	139299544	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:139299544G>A	ENST00000298537.7	-	6	1146	c.936_splice	c.e6+1	p.T312_splice	SDCCAG3_ENST00000357365.3_Splice_Site_p.T335_splice|SDCCAG3_ENST00000371725.3_Splice_Site_p.T262_splice|SDCCAG3_ENST00000461693.1_5'UTR	NM_006643.3	NP_006634.3	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3	335						cytoplasm				NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)	16		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		AACCCATACGGTCATCAGCTC	0.567000													8	73					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26239706	26239706	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:26239706C>T	ENST00000335473.7	+	18	3463	c.3213C>T	c.(3211-3213)tcC>tcT	p.S1071S	MYO18B_ENST00000536101.1_Silent_p.S1071S|MYO18B_ENST00000407587.2_Silent_p.S1072S	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1071	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TTCCAGGGTCCTCTGCCCTGC	0.577000													31	92					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751383	140751383	+	Silent	SNP	C	C	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:140751383C>G	ENST00000576222.1	+	1	1553	c.1422C>G	c.(1420-1422)gtC>gtG	p.V474V	PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGCGCATGTCAGAGCCTCGG	0.577000													4	180					0	0	1	0	0
IGHG3	3502	broad.mit.edu	37	14	106237699	106237699	+	RNA	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:106237699G>A	ENST00000390551.2	-	0	43																											AGGTGCTCCTGGAGCAGGGCG	0.677000													15	32					0	0	1	0	0
MYB	4602	broad.mit.edu	37	6	135517065	135517065	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:135517065C>T	ENST00000341911.5	+	9	1327	c.1128C>T	c.(1126-1128)atC>atT	p.I376I	MYB_ENST00000367814.4_Silent_p.I376I|MYB_ENST00000316528.8_Silent_p.I376I|MYB_ENST00000527615.1_Silent_p.I376I|MYB_ENST00000531845.1_3'UTR|MYB_ENST00000534044.1_Silent_p.I376I|MYB_ENST00000442647.2_Silent_p.I373I|MYB_ENST00000525369.1_Intron|MYB_ENST00000533624.1_Silent_p.I341I|MYB-AS1_ENST00000455534.1_RNA|MYB_ENST00000528774.1_Silent_p.I373I|MYB_ENST00000534121.1_Silent_p.I376I	NM_001130173.1|NM_001161656.1|NM_001161658.1	NP_001123645.1|NP_001155128.1|NP_001155130.1	P10242	MYB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog	376	Leucine-zipper.|Negative regulatory domain (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		GGTGCATGATCGTCCACCAGG	0.478000			T	NFIB	adenoid cystic carcinoma								17	45					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183673091	183673091	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:183673091C>T	ENST00000511685.1	+	20	3891	c.3768C>T	c.(3766-3768)gtC>gtT	p.V1256V	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Silent_p.V1256V					teneurin transmembrane protein 3																		ATGCAGAAGTCGTCGCAGGGA	0.537000													27	51					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6091022	6091022	+	Silent	SNP	T	T	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr20:6091022T>C	ENST00000217289.4	-	5	1457	c.669A>G	c.(667-669)caA>caG	p.Q223Q	FERMT1_ENST00000536936.1_Intron	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	223	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						ACTGGGGGGGTTGGCTGAATG	0.517000													18	43					0	0	1	0	0
FAM81B	153643	broad.mit.edu	37	5	94782360	94782360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:94782360G>A	ENST00000283357.5	+	8	1034	c.988G>A	c.(988-990)Ggc>Agc	p.G330S		NM_152548.2	NP_689761.2	Q96LP2	FA81B_HUMAN	family with sequence similarity 81, member B	330										central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		AGACCACCTGGGCCATATAAA	0.373000													13	38					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125192201	125192201	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:125192201C>T	ENST00000431078.1	+	5	1034	c.670C>T	c.(670-672)Cag>Tag	p.Q224*		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	224	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGGAGAAGGTCAGCGTGGAGA	0.512000													20	25					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7334696	7334696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:7334696G>A	ENST00000318881.6	+	3	805	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	SYT9_ENST00000396716.2_Missense_Mutation_p.E158K	NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	190						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		TCAAAAACAGGAACAGTTGAC	0.413000													15	43					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5569226	5569226	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:5569226G>A	ENST00000331789.5	-	2	254	c.63C>T	c.(61-63)ttC>ttT	p.F21F		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	21					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		CGTCGCCCGCGAAGCCGGCCT	0.716000													18	50					0	0	1	0	0
OR56A3	390083	broad.mit.edu	37	11	5968870	5968870	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:5968870C>T	ENST00000329564.6	+	1	301	c.294C>T	c.(292-294)ttC>ttT	p.F98F		NM_001003443.2	NP_001003443.2	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A, member 3	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(27)|stomach(1)|upper_aerodigestive_tract(1)	41		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCATCAGCTTCCCTGCCTGCT	0.532000													64	143					0	0	1	0	0
PIGR	5284	broad.mit.edu	37	1	207106358	207106358	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:207106358C>T	ENST00000356495.4	-	7	2042	c.1859G>A	c.(1858-1860)gGg>gAg	p.G620E		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	620						extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TGCTCTGCTCCCATCGGCTTG	0.557000													30	67					0	0	1	0	0
OBP2A	29991	broad.mit.edu	37	9	138439057	138439057	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:138439057G>A	ENST00000342114.4	+	2	148	c.106G>A	c.(106-108)Gat>Aat	p.D36N	OBP2A_ENST00000539850.1_Silent_p.L80L|OBP2A_ENST00000371776.1_Silent_p.L80L|OBP2A_ENST00000340780.3_Silent_p.L80L			Q9NY56	OBP2A_HUMAN	odorant binding protein 2A	46					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		AGAAAATCCTGATGCGGAAGA	0.642000													17	38					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49753675	49753675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:49753675G>A	ENST00000304801.3	-	1	1378	c.1226C>T	c.(1225-1227)cCt>cTt	p.P409L		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	409					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					CTCTACTCCAGGAAGGATTTT	0.453000													17	45					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33690598	33690598	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:33690598A>T	ENST00000394566.1	-	4	501	c.229T>A	c.(229-231)Tta>Ata	p.L77I	SLFN11_ENST00000308377.4_Missense_Mutation_p.L77I	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	77						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GACTGTTCTAAATCCAGTCCC	0.438000													58	111					0	0	1	0	0
ABHD2	11057	broad.mit.edu	37	15	89698693	89698693	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr15:89698693C>T	ENST00000352732.5	+	5	986	c.466C>T	c.(466-468)Cgg>Tgg	p.R156W	ABHD2_ENST00000565973.1_Missense_Mutation_p.R156W|ABHD2_ENST00000355100.3_Missense_Mutation_p.R156W	NM_152924.4	NP_690888.1	P08910	ABHD2_HUMAN	abhydrolase domain containing 2	156						integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|soft_tissue(1)	23	Lung NSC(78;0.0472)|all_lung(78;0.089)					AAATGGCTATCGGTGCGCCGT	0.517000													53	68					0	0	1	0	0
MIR325	442899	broad.mit.edu	37	X	76225910	76225910	+	RNA	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:76225910G>A	ENST00000385260.1	-	0	16					NR_029905.1																						acacctactaggaaccaagca	0.383000													39	84					0	0	1	0	0
ZNF624	57547	broad.mit.edu	37	17	16527594	16527594	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:16527594G>A	ENST00000311331.7	-	6	697	c.606C>T	c.(604-606)ggC>ggT	p.G202G		NM_020787.3	NP_065838.2	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(1)|prostate(1)|skin(1)	26				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CAAATCTAAAGCCTCTTTGAC	0.363000													25	50					0	0	1	0	0
GPATCH1	55094	broad.mit.edu	37	19	33608840	33608840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:33608840C>T	ENST00000170564.2	+	16	2620	c.2306C>T	c.(2305-2307)tCc>tTc	p.S769F		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	769						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					TCCTCATCCTCCGAGGATGAG	0.532000													22	18					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40940743	40940743	+	Silent	SNP	C	C	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:40940743C>A	ENST00000246914.5	+	11	2106	c.2085C>A	c.(2083-2085)acC>acA	p.T695T		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	695					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		AGCTACAGACCCATAACAGCA	0.527000													36	48					1.30998e-17	1.3339e-17	1	1	0
GRIA4	2893	broad.mit.edu	37	11	105623742	105623742	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:105623742T>A	ENST00000393127.2	+	4	729	c.283T>A	c.(283-285)Ttt>Att	p.F95I	GRIA4_ENST00000530497.1_Missense_Mutation_p.F95I|GRIA4_ENST00000525187.1_Missense_Mutation_p.F95I|GRIA4_ENST00000282499.5_Missense_Mutation_p.F95I|GRIA4_ENST00000393125.2_Missense_Mutation_p.F95I|GRIA4_ENST00000428631.2_Missense_Mutation_p.F95I	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	95					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ATTTGCCATTTTTGGACTCTA	0.428000													21	52					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43437862	43437862	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr18:43437862G>A	ENST00000282041.5	-	42	7432	c.7398C>T	c.(7396-7398)atC>atT	p.I2466I	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	2466					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						TTGCCCCCAGGATCCCAGAGC	0.512000													27	69					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124533000	124533000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:124533000C>T	ENST00000408936.3	+	11	2257	c.2075C>T	c.(2074-2076)tCc>tTc	p.S692F	DAB2IP_ENST00000259371.2_Missense_Mutation_p.S664F|DAB2IP_ENST00000309989.1_Missense_Mutation_p.S568F			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	692					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						AACGATCTTTCCGGGTAAGAG	0.582000													13	15					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46859773	46859773	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:46859773G>A	ENST00000262738.3	-	2	4013	c.4014C>T	c.(4012-4014)ttC>ttT	p.F1338F	CELSR1_ENST00000395964.1_Silent_p.F1338F	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1338	EGF-like 1; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GGATGGGCCGGAAGAGCACGG	0.657000													8	18					0	0	1	0	0
ABLIM2	84448	broad.mit.edu	37	4	8046937	8046937	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:8046937G>A	ENST00000318888.4	-	9	996	c.125C>T	c.(124-126)tCt>tTt	p.S42F	ABLIM2_ENST00000296372.8_Missense_Mutation_p.S285F|ABLIM2_ENST00000505872.1_Missense_Mutation_p.S285F|ABLIM2_ENST00000361737.5_Missense_Mutation_p.S285F|ABLIM2_ENST00000407564.3_Missense_Mutation_p.S285F|ABLIM2_ENST00000428004.2_Missense_Mutation_p.S285F|ABLIM2_ENST00000341937.5_Missense_Mutation_p.S285F|ABLIM2_ENST00000514025.1_Missense_Mutation_p.S42F|ABLIM2_ENST00000447017.2_Missense_Mutation_p.S285F|ABLIM2_ENST00000545242.1_Missense_Mutation_p.S285F|ABLIM2_ENST00000361581.5_Missense_Mutation_p.S285F|ABLIM2_ENST00000546334.1_Missense_Mutation_p.S285F			Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	285	LIM zinc-binding 1.				axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|pancreas(3)|prostate(2)|urinary_tract(1)	25						AGCAGGGACAGAAATGATGCT	0.547000													36	86					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50121162	50121162	+	RNA	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:50121162C>T	ENST00000376025.2	-	0	3104							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					GTCTCTGAATCCAGGCCTCCC	0.483000													18	52					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168834324	168834324	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:168834324G>A	ENST00000464456.1	-	7	1972	c.772C>T	c.(772-774)Cct>Tct	p.P258S	MECOM_ENST00000494292.1_Missense_Mutation_p.P446S|MECOM_ENST00000472280.1_Missense_Mutation_p.P259S|MECOM_ENST00000460814.1_Missense_Mutation_p.P258S|MECOM_ENST00000468789.1_Missense_Mutation_p.P258S|MECOM_ENST00000433243.2_Missense_Mutation_p.P259S|MECOM_ENST00000392736.3_Missense_Mutation_p.P258S|MECOM_ENST00000264674.3_Missense_Mutation_p.P323S	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GGGGTTCCAGGAAGTGAAATG	0.473000													36	68					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61305045	61305045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr18:61305045C>T	ENST00000341074.5	-	8	1196	c.1081G>A	c.(1081-1083)Gaa>Aaa	p.E361K	SERPINB4_ENST00000356424.6_Missense_Mutation_p.E309K	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						CAGAACTCTTCATTAGTTGAA	0.448000													30	87					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													7	181					0	0	1	0	0
OR8U1	219417	broad.mit.edu	37	11	56143815	56143815	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:56143815C>T	ENST00000302270.1	+	1	716	c.716C>T	c.(715-717)tCg>tTg	p.S239L		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					AAGGCTTTCTCGACGTGTGGC	0.473000													30	51					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11593400	11593400	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:11593400C>T	ENST00000262442.3	+	20	4329	c.4261C>T	c.(4261-4263)Cgg>Tgg	p.R1421W	DNAH9_ENST00000454412.2_Missense_Mutation_p.R1421W	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1421	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGATGAGGTCCGGGGCATTGT	0.562000													12	20					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48769852	48769852	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:48769852G>A	ENST00000314191.2	-	50	6527	c.6471C>T	c.(6469-6471)cgC>cgT	p.R2157R	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Silent_p.R2157R	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2158					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TCGCGTAAGGGCGAAAGACCT	0.418000								Non-homologous end-joining					12	22					0	0	1	0	0
XCR1	2829	broad.mit.edu	37	3	46063140	46063140	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:46063140G>A	ENST00000309285.3	-	2	656	c.300C>T	c.(298-300)ttC>ttT	p.F100F	XCR1_ENST00000542109.1_Silent_p.F100F	NM_001024644.1	NP_001019815.1	P46094	XCR1_HUMAN	chemokine (C motif) receptor 1	100					chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(2)	14				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		GTTTGCAGAGGAAGTCTCCCA	0.542000													14	15					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61309074	61309074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr18:61309074C>T	ENST00000341074.5	-	4	386	c.271G>A	c.(271-273)Gaa>Aaa	p.E91K	SERPINB4_ENST00000356424.6_Missense_Mutation_p.E91K	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						TTGTTGAATTCAGTCAGAAGC	0.383000													51	81					0	0	1	0	0
ITPKB	3707	broad.mit.edu	37	1	226924619	226924619	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:226924619G>A	ENST00000429204.1	-	2	868	c.541C>T	c.(541-543)Cgc>Tgc	p.R181C	ITPKB_ENST00000366784.1_Missense_Mutation_p.R181C|ITPKB_ENST00000272117.3_Missense_Mutation_p.R181C	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	181							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				CTGCTGCTGCGGAAGGGGCAC	0.677000													36	63					0	0	1	0	0
ME2	4200	broad.mit.edu	37	18	48473476	48473476	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr18:48473476G>A	ENST00000321341.5	+	16	1949	c.1677G>A	c.(1675-1677)cgG>cgA	p.R559R	ME2_ENST00000585680.1_3'UTR|ME2_ENST00000382927.3_3'UTR	NM_002396.4	NP_002387.1	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	559					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(3)	23		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	GAACATGGCGGAGTGAATATG	0.403000													39	87					0	0	1	0	0
AOC4P	90586	broad.mit.edu	37	17	41020607	41020607	+	RNA	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:41020607C>T	ENST00000585538.1	+	0	1446					NR_002773.1																						CCAGGGCCTCCCCCTGCGGCG	0.537000													7	23					0	0	1	0	0
LCA5	167691	broad.mit.edu	37	6	80196841	80196841	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:80196841G>A	ENST00000392959.1	-	9	2585	c.1974C>T	c.(1972-1974)ttC>ttT	p.F658F	LCA5_ENST00000369846.4_Silent_p.F658F	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	658					protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		CTTCACTGAGGAAAAAGCCTT	0.398000													20	58					0	0	1	0	0
SLC2A9	56606	broad.mit.edu	37	4	9892285	9892285	+	Silent	SNP	A	A	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:9892285A>G	ENST00000506583.1	-	11	1294	c.1077T>C	c.(1075-1077)ttT>ttC	p.F359F	SLC2A9_ENST00000309065.3_Silent_p.F359F|SLC2A9_ENST00000264784.3_Silent_p.F388F			Q9NRM0	GTR9_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 9	388					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(1)	35						CCATGAGCCCAAAGCCACCAA	0.517000													12	32					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100832313	100832313	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:100832313T>C	ENST00000358544.2	+	49	9143	c.9032T>C	c.(9031-9033)gTt>gCt	p.V3011A	VPS13B_ENST00000357162.2_Missense_Mutation_p.V2986A|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3011					protein transport			p.V3011D(1)		NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GTTCTACAGGTTCCTGCTGGC	0.353000													54	64					0	0	1	0	0
SLC17A1	6568	broad.mit.edu	37	6	25826765	25826765	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:25826765A>G	ENST00000244527.4	-	3	246	c.131T>C	c.(130-132)aTg>aCg	p.M44T	SLC17A1_ENST00000468082.1_Missense_Mutation_p.M44T|SLC17A1_ENST00000476801.1_Missense_Mutation_p.M44T|SLC17A1_ENST00000427328.1_Missense_Mutation_p.M44T	NM_005074.3	NP_005065.2	Q14916	NPT1_HUMAN	solute carrier family 17 (organic anion transporter), member 1	44					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	36						CATGACTACCATTGTGAGGTT	0.433000													53	99					0	0	1	0	0
ZC3H10	84872	broad.mit.edu	37	12	56515236	56515236	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:56515236C>T	ENST00000257940.2	+	3	1166	c.890C>T	c.(889-891)cCc>cTc	p.P297L	RP11-603J24.5_ENST00000550947.1_RNA|RP11-603J24.5_ENST00000549438.1_RNA	NM_032786.1	NP_116175.1	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	297							nucleic acid binding|zinc ion binding			breast(1)|endometrium(4)|large_intestine(1)|lung(2)|prostate(2)|skin(1)	11			OV - Ovarian serous cystadenocarcinoma(18;0.12)			ACTCTGGCCCCCACTGTGGGC	0.547000													18	28					0	0	1	0	0
PEPD	5184	broad.mit.edu	37	19	33892682	33892682	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:33892682G>A	ENST00000244137.6	-	12	945	c.912C>T	c.(910-912)gcC>gcT	p.A304A	PEPD_ENST00000436370.3_Silent_p.A240A|PEPD_ENST00000397032.4_Silent_p.A263A	NM_000285.3	NP_000276.2	P12955	PEPD_HUMAN	peptidase D	304					cellular amino acid metabolic process|collagen catabolic process|proteolysis		aminopeptidase activity|dipeptidase activity|manganese ion binding|metallocarboxypeptidase activity			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)	17	Esophageal squamous(110;0.137)					CCTCATAGACGGCCTTCTGGT	0.627000													4	14					0	0	1	0	0
TTLL10	254173	broad.mit.edu	37	1	1115635	1115635	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:1115635C>T	ENST00000379290.1	+	6	594	c.421C>T	c.(421-423)Ctc>Ttc	p.L141F	TTLL10_ENST00000379288.3_Missense_Mutation_p.L68F|TTLL10_ENST00000379289.1_Missense_Mutation_p.L141F			Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	141					protein modification process		ATP binding|tubulin-tyrosine ligase activity			haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCTGGAGGGGCTCCTGCTGGG	0.692000													6	3					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11141561	11141561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:11141561C>T	ENST00000358026.2	+	25	3822	c.3538C>T	c.(3538-3540)Cct>Tct	p.P1180S	SMARCA4_ENST00000541122.2_Missense_Mutation_p.P1180S|SMARCA4_ENST00000444061.3_Missense_Mutation_p.P1180S|SMARCA4_ENST00000590574.1_Missense_Mutation_p.P1180S|SMARCA4_ENST00000429416.3_Missense_Mutation_p.P1180S|SMARCA4_ENST00000589677.1_Missense_Mutation_p.P1180S|SMARCA4_ENST00000344626.4_Missense_Mutation_p.P1180S|SMARCA4_ENST00000413806.3_Missense_Mutation_p.P1180S|SMARCA4_ENST00000450717.3_Missense_Mutation_p.P1180S	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1180	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CGACTGGAATCCTCACCAGGT	0.617000			"""F, N, Mis"""		NSCLC								4	2					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117744304	117744304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:117744304C>T	ENST00000276204.6	+	28	3093	c.3019C>T	c.(3019-3021)Ccc>Tcc	p.P1007S	DOCK11_ENST00000276202.7_Missense_Mutation_p.P1007S			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1007					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						TGCAATAATTCCCCATGTGAC	0.443000													22	66					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142655480	142655480	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:142655480C>T	ENST00000355265.2	-	5	910	c.436G>A	c.(436-438)Gag>Aag	p.E146K	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	146					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					AAGGCTTTCTCCTCCCCAGAG	0.478000													13	45					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57180913	57180913	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:57180913G>A	ENST00000504228.1	+	6	1350	c.1245G>A	c.(1243-1245)tgG>tgA	p.W415*	KIAA1211_ENST00000264229.6_Nonsense_Mutation_p.W415*|KIAA1211_ENST00000541073.1_Nonsense_Mutation_p.W408*			Q6ZU35	K1211_HUMAN	KIAA1211	415	Glu-rich.									endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					TGGAGGACTGGAGGGGGCAGC	0.657000													4	6					0	0	1	0	0
OR2AT4	341152	broad.mit.edu	37	11	74799928	74799928	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:74799928G>A	ENST00000305159.3	-	1	871	c.831C>T	c.(829-831)atC>atT	p.I277I		NM_001005285.1	NP_001005285.1	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT, member 4	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(2)	12						CATTGCCCATGATATGGAAGT	0.512000													30	69					0	0	1	0	0
SLC6A7	6534	broad.mit.edu	37	5	149576346	149576346	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:149576346C>T	ENST00000230671.2	+	3	656	c.285C>T	c.(283-285)ctC>ctT	p.L95L	SLC6A7_ENST00000524041.1_Silent_p.L95L	NM_014228.3	NP_055043.2	Q99884	SC6A7_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 7	95						integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(1)|stomach(1)	16		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	TCCTGGAGCTCTCCCTGGGCC	0.642000													63	156					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9071650	9071650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:9071650C>T	ENST00000397910.4	-	3	15999	c.15796G>A	c.(15796-15798)Gaa>Aaa	p.E5266K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5268	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATCGTCATTTCTGCAGATTTT	0.512000													27	34					0	0	1	0	0
PLK4	10733	broad.mit.edu	37	4	128811345	128811345	+	Missense_Mutation	SNP	T	T	C	rs60587538		TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:128811345T>C	ENST00000270861.5	+	7	2058	c.1784T>C	c.(1783-1785)gTt>gCt	p.V595A	PLK4_ENST00000515069.1_Missense_Mutation_p.V517A|PLK4_ENST00000507249.1_Missense_Mutation_p.V561A|PLK4_ENST00000513090.1_Missense_Mutation_p.V563A|PLK4_ENST00000514379.1_Missense_Mutation_p.V554A	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	595					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						TCTCCGTTGGTTGCTCACAGG	0.388000													17	30					0	0	1	0	0
C3orf30	152405	broad.mit.edu	37	3	118867060	118867060	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:118867060T>C	ENST00000295622.1	+	2	1472	c.1432T>C	c.(1432-1434)Tat>Cat	p.Y478H	RP11-484M3.5_ENST00000490594.1_Intron	NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	478										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		AGGAAAGGGTTATCATATACG	0.368000													23	71					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75278336	75278336	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:75278336C>T	ENST00000325680.7	+	10	5366	c.5242C>T	c.(5242-5244)Cga>Tga	p.R1748*	YLPM1_ENST00000552421.1_Nonsense_Mutation_p.R1042*|YLPM1_ENST00000238571.3_Nonsense_Mutation_p.R1553*	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1553					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		TCAGTCATATCGAGACAAAAA	0.433000													13	32					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62257208	62257208	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:62257208G>A	ENST00000474889.1	+	21	3537	c.3160G>A	c.(3160-3162)Ggc>Agc	p.G1054S	PTPRG-AS1_ENST00000474795.1_RNA|PTPRG-AS1_ENST00000479018.1_RNA|PTPRG-AS1_ENST00000462497.1_RNA|PTPRG-AS1_ENST00000475371.1_RNA|PTPRG-AS1_ENST00000495542.1_RNA|PTPRG_ENST00000295874.10_Missense_Mutation_p.G1025S	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	1054	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		GCCAGAAACGGGCCCTGTGTT	0.532000													19	33					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128339518	128339518	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:128339518G>A	ENST00000389524.4	+	11	1186	c.1133G>A	c.(1132-1134)cGa>cAa	p.R378Q	MYO7B_ENST00000428314.1_Missense_Mutation_p.R378Q|MYO7B_ENST00000409816.2_Missense_Mutation_p.R378Q			Q6PIF6	MYO7B_HUMAN	myosin VIIB	378	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ATCCTCATCCGAGGGGAATTT	0.627000													43	84					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33608316	33608316	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:33608316C>T	ENST00000374316.5	+	3	1205	c.145C>T	c.(145-147)Cct>Tct	p.P49S	ITPR3_ENST00000605930.1_Missense_Mutation_p.P49S			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	49					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						GGACAACCCCCCTAAGAAGTT	0.612000													51	151					0	0	1	0	0
ZBTB46	140685	broad.mit.edu	37	20	62421280	62421280	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr20:62421280C>T	ENST00000245663.4	-	2	981	c.831G>A	c.(829-831)gaG>gaA	p.E277E	ZBTB46_ENST00000395104.1_Silent_p.E277E|ZBTB46_ENST00000302995.2_Silent_p.E277E	NM_025224.3	NP_079500.2	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	277					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					GCCGGACGGTCTCTTTGTTTT	0.617000													31	76					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	20869165	20869165	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:20869165G>A	ENST00000298925.5	+	5	609	c.456G>A	c.(454-456)gaG>gaA	p.E152E	NELL1_ENST00000325319.5_Intron|NELL1_ENST00000357134.5_Silent_p.E124E|NELL1_ENST00000532434.1_Silent_p.E124E			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	124	TSP N-terminal.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						TGAGGGATGAGATTCGGTATC	0.448000													9	33					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6062751	6062751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:6062751C>T	ENST00000261405.5	-	48	8151	c.7897G>A	c.(7897-7899)Gaa>Aaa	p.E2633K		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2633	VWFC 3.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TTATTTTCTTCCTTGTAACCC	0.463000													27	75					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35965594	35965594	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:35965594G>A	ENST00000490799.1	-	5	901	c.548C>T	c.(547-549)tCg>tTg	p.S183L	SLC26A8_ENST00000355574.2_Missense_Mutation_p.S183L|SLC26A8_ENST00000394602.2_Missense_Mutation_p.S183L	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	183					cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						GGAGGGGGCCGAAAACTCATT	0.458000													17	36					0	0	1	0	0
CD86	942	broad.mit.edu	37	3	121825236	121825236	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:121825236G>A	ENST00000330540.2	+	4	708	c.592G>A	c.(592-594)Gac>Aac	p.D198N	CD86_ENST00000493101.1_Missense_Mutation_p.D86N|CD86_ENST00000393627.2_Missense_Mutation_p.D192N|CD86_ENST00000264468.5_Intron|CD86_ENST00000469710.1_Missense_Mutation_p.D116N	NM_175862.4	NP_787058.4	P42081	CD86_HUMAN	CD86 molecule	198	Ig-like C2-type.				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	23				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	AGAACTGTACGACGTTTCCAT	0.398000													35	72					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110448605	110448605	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:110448605G>A	ENST00000378402.5	+	30	3648	c.3544G>A	c.(3544-3546)Gaa>Aaa	p.E1182K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1182	IPT/TIG 5.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGGCTTTAATGAAAATTCAAA	0.343000										HNSCC(38;0.096)			17	42					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237729923	237729923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:237729923G>A	ENST00000366574.2	+	28	3588	c.3271G>A	c.(3271-3273)Gag>Aag	p.E1091K	RYR2_ENST00000360064.6_Missense_Mutation_p.E1089K|RYR2_ENST00000542537.1_Missense_Mutation_p.E1075K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1091	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTTCCGTGCCGAGAAGACCTA	0.557000													37	73					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152831380	152831380	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:152831380G>A	ENST00000367255.5	-	8	1130	c.529C>T	c.(529-531)Caa>Taa	p.Q177*	SYNE1_ENST00000413186.2_Nonsense_Mutation_p.Q177*|SYNE1_ENST00000341594.5_Nonsense_Mutation_p.Q177*|SYNE1_ENST00000367253.4_Nonsense_Mutation_p.Q177*|SYNE1_ENST00000448038.1_Nonsense_Mutation_p.Q184*|SYNE1_ENST00000423061.1_Nonsense_Mutation_p.Q184*|SYNE1_ENST00000265368.4_Nonsense_Mutation_p.Q177*|SYNE1_ENST00000466159.2_Nonsense_Mutation_p.Q177*|SYNE1_ENST00000367248.3_Nonsense_Mutation_p.Q184*	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	177	Actin-binding.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCATTTCCTTGGATCTTGGTG	0.453000										HNSCC(10;0.0054)			28	91					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105410776	105410776	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:105410776T>A	ENST00000333244.5	-	7	11131	c.11012A>T	c.(11011-11013)gAt>gTt	p.D3671V	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3671						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GAGACTCACATCGGCTTCCAC	0.582000													90	188					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116548736	116548736	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:116548736C>T	ENST00000410059.1	+	18	2091	c.1611C>T	c.(1609-1611)atC>atT	p.I537I	DPP10_ENST00000310323.8_Silent_p.I530I|DPP10_ENST00000393147.2_Silent_p.I541I|DPP10_ENST00000409163.1_Silent_p.I487I	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	537					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						AAATTAAAATCCTTCATATTG	0.338000													3	20					0	0	1	0	0
PRDM1	639	broad.mit.edu	37	6	106553230	106553230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:106553230C>T	ENST00000369096.4	+	5	1429	c.1195C>T	c.(1195-1197)Ccg>Tcg	p.P399S	PRDM1_ENST00000369089.3_Missense_Mutation_p.P265S|PRDM1_ENST00000369091.2_Missense_Mutation_p.P363S	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	399					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		GCCCCACCTCCCGCCAGCTTT	0.602000			"""D, N, Mis, F, S"""		DLBCL								24	40					0	0	1	0	0
EDEM1	9695	broad.mit.edu	37	3	5246867	5246867	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:5246867A>T	ENST00000256497.4	+	6	1291	c.1158A>T	c.(1156-1158)aaA>aaT	p.K386N	EDEM1_ENST00000445686.1_Missense_Mutation_p.K191N	NM_014674.2	NP_055489.1	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like 1	386					ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		TTGGAGAAAAAGAAGACCTAG	0.443000													28	47					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560257	44560257	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr18:44560257G>A	ENST00000332567.4	-	1	1731	c.1379C>T	c.(1378-1380)tCa>tTa	p.S460L	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	460					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CCAGAGCTCTGAGAAGACATG	0.597000													41	99					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81688675	81688675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:81688675C>T	ENST00000550584.2	-	23	3159	c.2864G>A	c.(2863-2865)cGa>cAa	p.R955Q	PPFIA2_ENST00000443686.3_Missense_Mutation_p.R856Q|PPFIA2_ENST00000407050.4_Missense_Mutation_p.R881Q|PPFIA2_ENST00000541570.2_Missense_Mutation_p.R522Q|PPFIA2_ENST00000552948.1_Missense_Mutation_p.R955Q|PPFIA2_ENST00000548586.1_Missense_Mutation_p.R955Q|RP11-121G22.3_ENST00000549161.1_lincRNA|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000333447.7_Missense_Mutation_p.R940Q|PPFIA2_ENST00000541017.1_Missense_Mutation_p.R172Q|PPFIA2_ENST00000549396.1_Missense_Mutation_p.R955Q|PPFIA2_ENST00000549325.1_Missense_Mutation_p.R940Q|PPFIA2_ENST00000550359.2_Missense_Mutation_p.R802Q	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	881										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						GATTGCTAATCGAAGTTTTAA	0.483000													11	20					0	0	1	0	0
RANBP9	10048	broad.mit.edu	37	6	13642770	13642770	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:13642770A>C	ENST00000011619.3	-	7	1224	c.1166T>G	c.(1165-1167)tTt>tGt	p.F389C	RANBP9_ENST00000539980.1_Missense_Mutation_p.F160C	NM_005493.2	NP_005484.2	Q96S59	RANB9_HUMAN	RAN binding protein 9	389	LisH.				axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	16	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			AGATCTGGCAAAGGCCTCTGC	0.378000													16	38					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13841033	13841033	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:13841033C>T	ENST00000265104.4	-	34	5795	c.5691G>A	c.(5689-5691)agG>agA	p.R1897R		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1897	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CAAAGATATCCCTTTGGTGCA	0.398000									Kartagener syndrome				14	43					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17542898	17542898	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:17542898C>T	ENST00000005226.7	-	13	1079	c.1080G>A	c.(1078-1080)atG>atA	p.M360I	USH1C_ENST00000527720.1_Missense_Mutation_p.M329I|USH1C_ENST00000527020.1_Missense_Mutation_p.M341I|USH1C_ENST00000318024.4_Missense_Mutation_p.M360I	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	360					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						CTCACTGTTCCATCTCCTTCC	0.512000													49	126					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43405718	43405718	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:43405718C>T	ENST00000244533.3	+	5	2197	c.1838C>T	c.(1837-1839)tCc>tTc	p.S613F	ABCC10_ENST00000372530.4_Missense_Mutation_p.S641F	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	641	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGGAAGAGCTCCCTGCTGGCT	0.562000													6	7					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41009884	41009884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:41009884C>T	ENST00000352632.3	+	12	1596	c.1510C>T	c.(1510-1512)Cgg>Tgg	p.R504W	SPTBN4_ENST00000338932.3_Missense_Mutation_p.R504W|SPTBN4_ENST00000598249.1_Missense_Mutation_p.R504W|SPTBN4_ENST00000595535.1_Missense_Mutation_p.R504W|SPTBN4_ENST00000344104.3_Missense_Mutation_p.R504W			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	504					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTACGATATCCGGCGGGTGGC	0.662000													19	24					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039158	11039158	+	RNA	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr21:11039158G>A	ENST00000470054.1	-	0	1045									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCTCATGTGGGGACACTAAGG	0.398000													15	268					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559284	140559284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:140559284G>A	ENST00000239444.2	+	1	1914	c.1669G>A	c.(1669-1671)Gac>Aac	p.D557N		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		557	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGACGCCAACGACAACTCGCC	0.711000													32	81					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128781675	128781675	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:128781675G>A	ENST00000529694.1	+	2	883	c.507G>A	c.(505-507)ttG>ttA	p.L169L	KCNJ5_ENST00000533599.1_Silent_p.L169L|KCNJ5_ENST00000338350.4_Silent_p.L169L	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	169					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	TACTCCTCTTGGTCCAGGCCA	0.522000													50	113					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154395273	154395273	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:154395273G>A	ENST00000435029.4	+	1	2014	c.1854G>A	c.(1852-1854)gaG>gaA	p.E618E		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	618					axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AACTGAATGAGCAGTCCAAAC	0.458000													33	70					0	0	1	0	0
CLDND1	56650	broad.mit.edu	37	3	98240107	98240107	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:98240107G>A	ENST00000503004.1	-	2	1041	c.162C>T	c.(160-162)ttC>ttT	p.F54F	CLDND1_ENST00000513287.1_Silent_p.F54F|CLDND1_ENST00000341181.6_Silent_p.F54F|CLDND1_ENST00000508503.1_5'UTR|CLDND1_ENST00000507874.1_Silent_p.F54F|CLDND1_ENST00000502288.1_Intron|CLDND1_ENST00000394180.2_Silent_p.F54F|CLDND1_ENST00000394185.2_Silent_p.F54F|CLDND1_ENST00000511081.1_Intron|CLDND1_ENST00000437922.1_Silent_p.F77F|CLDND1_ENST00000510545.1_Silent_p.F54F|CLDND1_ENST00000394181.2_Silent_p.F54F			Q9NY35	CLDN1_HUMAN	claudin domain containing 1	54						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	9						CATCACTAATGAATTCATCCC	0.403000													14	44					0	0	1	0	0
OR9G1	390174	broad.mit.edu	37	11	56468246	56468246	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:56468246C>T	ENST00000312153.1	+	1	383	c.383C>T	c.(382-384)cCc>cTc	p.P128L		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						ATCTCCAAGCCCCTGCTTTAT	0.517000													30	129					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29793125	29793125	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr18:29793125G>A	ENST00000269202.6	+	11	1229	c.1182G>A	c.(1180-1182)gtG>gtA	p.V394V	MEP1B_ENST00000581447.1_Silent_p.V394V	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	394	MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						CATTGAAAGTGACCAAGAAGT	0.413000													24	43					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149247919	149247919	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:149247919T>G	ENST00000407073.1	+	12	5016	c.4019T>G	c.(4018-4020)tTt>tGt	p.F1340C	MBD5_ENST00000404807.1_Missense_Mutation_p.F1573C	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1340						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		AATGGAGACTTTAATGCCAAA	0.438000													19	38					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182207	140182207	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:140182207C>T	ENST00000522353.2	+	1	1425	c.1425C>T	c.(1423-1425)ttC>ttT	p.F475F	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000520672.2_Intron|PCDHA3_ENST00000532566.2_Silent_p.F475F|PCDHA2_ENST00000526136.1_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCACATCTTCACGGTGTCTG	0.667000													5	213					0	0	1	0	0
CXCR1	3577	broad.mit.edu	37	2	219029413	219029413	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:219029413G>A	ENST00000295683.2	-	2	642	c.522C>T	c.(520-522)ttC>ttT	p.F174F		NM_000634.2	NP_000625.1	P25024	CXCR1_HUMAN	chemokine (C-X-C motif) receptor 1	174					dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(3)	13						AAGCCTGGCGGAAAAGGAAGA	0.517000													14	40					0	0	1	0	0
ZNF713	349075	broad.mit.edu	37	7	56007351	56007351	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:56007351C>T	ENST00000429591.2	+	4	983	c.945C>T	c.(943-945)tcC>tcT	p.S315S	MRPS17_ENST00000426595.1_Intron	NM_182633.1	NP_872439.1	Q8N859	ZN713_HUMAN	zinc finger protein 713	315					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AGCATTCATCCTTTACTCAAC	0.403000													42	75					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90438746	90438746	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:90438746C>T	ENST00000369393.3	-	36	5368	c.5253G>A	c.(5251-5253)ctG>ctA	p.L1751L	MDN1_ENST00000428876.1_Silent_p.L1751L			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1751					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GGGAACCCTCCAGGAGAATGG	0.463000													18	41					0	0	1	0	0
PTK7	5754	broad.mit.edu	37	6	43096872	43096872	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:43096872C>T	ENST00000230419.4	+	2	458	c.237C>T	c.(235-237)ttC>ttT	p.F79F	PTK7_ENST00000352931.2_Silent_p.F79F|PTK7_ENST00000345201.2_Silent_p.F79F|PTK7_ENST00000471863.1_Silent_p.F79F|PTK7_ENST00000349241.2_Silent_p.F79F|PTK7_ENST00000476760.1_Silent_p.F79F|PTK7_ENST00000481273.1_Silent_p.F87F	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	79	Ig-like C2-type 1.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			AGCGGCGTTTCGCCCAGGGCA	0.662000													23	31					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677213	37677213	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:37677213G>A	ENST00000532828.2	-	5	1477	c.1226C>T	c.(1225-1227)tCg>tTg	p.S409L	ZNF585B_ENST00000312908.5_5'UTR|CTC-454I21.3_ENST00000585860.2_Intron|ZNF585B_ENST00000527838.1_3'UTR|ZNF585B_ENST00000531805.1_Missense_Mutation_p.S354L	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GCATATATACGATTTTTCTCC	0.423000													21	23					0	0	1	0	0
LRRC43	254050	broad.mit.edu	37	12	122674734	122674734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:122674734G>A	ENST00000339777.4	+	5	748	c.720G>A	c.(718-720)atG>atA	p.M240I	LRRC43_ENST00000425921.1_Missense_Mutation_p.M55I	NM_152759.4	NP_689972.3	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43	240										NS(1)|endometrium(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(2)	19	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		TGCAGAGCATGGTCACCAGCC	0.647000													56	107					0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89431672	89431672	+	RNA	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:89431672G>A	ENST00000532352.1	+	0	1954							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						AAGCAAAGTGGACCCTTCCAA	0.483000													40	96					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123969945	123969945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr10:123969945G>A	ENST00000369005.1	+	9	6345	c.6005G>A	c.(6004-6006)gGc>gAc	p.G2002D	TACC2_ENST00000515273.1_Missense_Mutation_p.G2006D|TACC2_ENST00000369000.1_5'UTR|TACC2_ENST00000453444.2_Missense_Mutation_p.G2006D|TACC2_ENST00000515603.1_Missense_Mutation_p.G1957D|TACC2_ENST00000368999.1_Missense_Mutation_p.G80D|TACC2_ENST00000369004.3_Missense_Mutation_p.G80D|TACC2_ENST00000260733.3_Missense_Mutation_p.G80D|TACC2_ENST00000493951.1_3'UTR|TACC2_ENST00000358010.1_Missense_Mutation_p.G148D|TACC2_ENST00000369001.1_5'UTR|TACC2_ENST00000360561.3_Missense_Mutation_p.G80D|TACC2_ENST00000334433.3_Missense_Mutation_p.G2002D|TACC2_ENST00000513429.1_Missense_Mutation_p.G148D	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2002	Pro-rich.					microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GTCCCTGATGGCCCACGGAGC	0.572000													6	10					0	0	1	0	0
FCER1A	2205	broad.mit.edu	37	1	159273754	159273754	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:159273754G>A	ENST00000368115.1	+	4	212	c.113G>A	c.(112-114)tGg>tAg	p.W38*	FCER1A_ENST00000368114.1_Intron	NM_002001.3	NP_001992.1	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	38	Ig-like 1.					integral to plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(19)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	AACCCTCCATGGAATAGAATA	0.368000													15	35					0	0	1	0	0
ARGFX	503582	broad.mit.edu	37	3	121303794	121303794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:121303794C>T	ENST00000334384.3	+	3	261	c.251C>T	c.(250-252)tCt>tTt	p.S84F		NM_001012659.1	NP_001012677.1	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	84						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15				GBM - Glioblastoma multiforme(114;0.152)		GAACGTACTTCTTTCACCCAC	0.438000													61	131					0	0	1	0	0
NFRKB	4798	broad.mit.edu	37	11	129739745	129739745	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:129739745G>A	ENST00000446488.3	-	23	3278	c.3175C>T	c.(3175-3177)Cgc>Tgc	p.R1059C	NFRKB_ENST00000524794.1_Missense_Mutation_p.R1084C|NFRKB_ENST00000304521.5_Missense_Mutation_p.R1059C|NFRKB_ENST00000524746.1_Missense_Mutation_p.R1059C	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	1059					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GGCATCAAGCGAAAAGCCGAA	0.552000													12	46					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688983	26688983	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:26688983G>A	ENST00000529632.2	+	2	902	c.706G>A	c.(706-708)Gac>Aac	p.D236N	SEZ6L_ENST00000403121.1_Missense_Mutation_p.D9N|SEZ6L_ENST00000360929.3_Missense_Mutation_p.D236N|SEZ6L_ENST00000343706.4_Missense_Mutation_p.D236N|SEZ6L_ENST00000404234.3_Missense_Mutation_p.D236N|SEZ6L_ENST00000248933.6_Missense_Mutation_p.D236N|SEZ6L_ENST00000402979.1_Missense_Mutation_p.D9N	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	236						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CCCCCAGGAGGACACCAGCCC	0.637000													26	50					0	0	1	0	0
SAA2	6289	broad.mit.edu	37	11	18266985	18266985	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:18266985C>T	ENST00000526900.1	-	4	491	c.308G>A	c.(307-309)tGg>tAg	p.W103*	SAA2_ENST00000256733.4_Nonsense_Mutation_p.W103*|SAA2_ENST00000530400.1_Intron|SAA2_ENST00000529528.1_Nonsense_Mutation_p.W103*|SAA2_ENST00000528349.1_Intron|SAA2-SAA4_ENST00000524555.1_RNA|SAA2_ENST00000414546.2_Intron					serum amyloid A2											central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(1)	6						ACTCCTGCCCCATTTATTGGC	0.567000													16	45					0	0	1	0	0
FAM122B	159090	broad.mit.edu	37	X	133922779	133922779	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:133922779G>A	ENST00000370790.1	-	5	1287	c.359C>T	c.(358-360)cCc>cTc	p.P120L	FAM122B_ENST00000486347.1_Missense_Mutation_p.P120L|FAM122B_ENST00000343004.5_Missense_Mutation_p.P139L|FAM122B_ENST00000493333.1_5'UTR|FAM122B_ENST00000298090.6_Missense_Mutation_p.P139L	NM_001166599.2|NM_145284.5	NP_001160071.1|NP_660327.2	Q7Z309	F122B_HUMAN	family with sequence similarity 122B	120										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|skin(1)	6	Acute lymphoblastic leukemia(192;0.000127)					TCCCCTGGTGGGTGAAGGTGC	0.398000													25	28					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739353	38739353	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:38739353G>A	ENST00000449082.2	-	27	5357	c.5358C>T	c.(5356-5358)atC>atT	p.I1786I		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1786					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGTCCATCTGGATCAGTATAT	0.478000													27	39					0	0	1	0	0
OR1K1	392392	broad.mit.edu	37	9	125562841	125562841	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:125562841G>A	ENST00000277309.2	+	1	472	c.440G>A	c.(439-441)gGa>gAa	p.G147E		NM_080859.1	NP_543135.1	Q8NGR3	OR1K1_HUMAN	olfactory receptor, family 1, subfamily K, member 1	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(8)|lung(2)|ovary(1)|skin(4)|stomach(1)	17						GCCCTGGTGGGAATGGCATGG	0.617000													8	54					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123812483	123812483	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:123812483C>T	ENST00000223642.1	-	1	71	c.42G>A	c.(40-42)ggG>ggA	p.G14G		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	14					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	CCCAGGTTTTCCCCAGGAAGA	0.373000													9	112					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38927711	38927711	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:38927711C>T	ENST00000450244.1	-	16	3052	c.2854G>A	c.(2854-2856)Gag>Aag	p.E952K	SCN11A_ENST00000456224.3_Intron|SCN11A_ENST00000302328.3_Missense_Mutation_p.E952K|SCN11A_ENST00000444237.2_Missense_Mutation_p.E952K			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	952					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TTCTTGTTCTCCTGATGGAGC	0.433000													5	20					0	0	1	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709513	128709513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:128709513C>T	ENST00000392665.2	-	2	770	c.626G>A	c.(625-627)gGa>gAa	p.G209E	KCNJ1_ENST00000392666.1_Missense_Mutation_p.G209E|KCNJ1_ENST00000392664.2_Missense_Mutation_p.G228E|KCNJ1_ENST00000324036.3_Missense_Mutation_p.G209E|KCNJ1_ENST00000440599.2_Missense_Mutation_p.G209E	NM_153764.2	NP_722448.1	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 1	228					excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			breast(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)	23	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CAGAAGCTTTCCATAAATGTG	0.443000													49	90					0	0	1	0	0
CD81-AS1	101927682	broad.mit.edu	37	11	2356706	2356706	+	RNA	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:2356706C>T	ENST00000413483.1	-	0	407				RPL26P30_ENST00000602923.1_RNA																							ACAGTCGTGCCGTTGGCCTTC	0.488000													65	129					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202425	140202425	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:140202425C>T	ENST00000529859.1	+	1	1065	c.1065C>T	c.(1063-1065)ttC>ttT	p.F355F	PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Silent_p.F355F|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000378126.3_Silent_p.F355F|PCDHA2_ENST00000526136.1_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACCCTTTTCCTGCCTGTCA	0.498000													38	63					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9360725	9360725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr20:9360725G>A	ENST00000378501.2	+	10	784	c.769G>A	c.(769-771)Gaa>Aaa	p.E257K	PLCB4_ENST00000378493.1_Missense_Mutation_p.E257K|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000378473.3_Missense_Mutation_p.E257K|PLCB4_ENST00000334005.3_Missense_Mutation_p.E257K|PLCB4_ENST00000278655.4_Missense_Mutation_p.E257K|PLCB4_ENST00000414679.2_Missense_Mutation_p.E257K	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	257					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TCGATTGAATGAAATTTTATT	0.308000													8	22					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68156440	68156440	+	Silent	SNP	C	C	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr16:68156440C>A	ENST00000349223.5	+	2	878	c.654C>A	c.(652-654)ggC>ggA	p.G218G	NFATC3_ENST00000346183.3_Silent_p.G218G|NFATC3_ENST00000329524.4_Silent_p.G218G|NFATC3_ENST00000575270.1_Silent_p.G218G|NFATC3_ENST00000535127.2_3'UTR	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	218	3 X SP repeats.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		CTCCAGGGGGCTGCCCTGGAG	0.498000													33	69					3.90053e-15	3.96369e-15	1	1	0
FYB	2533	broad.mit.edu	37	5	39202662	39202662	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:39202662C>T	ENST00000351578.6	-	2	591	c.401G>A	c.(400-402)gGa>gAa	p.G134E	FYB_ENST00000540520.1_Missense_Mutation_p.G144E|FYB_ENST00000505428.1_Missense_Mutation_p.G134E|FYB_ENST00000512982.1_Missense_Mutation_p.G134E|FYB_ENST00000515010.1_Missense_Mutation_p.G134E	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	134					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			TGGCTTGTTTCCAGGAGGCCA	0.498000													40	70					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21686973	21686973	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr20:21686973G>A	ENST00000444366.2	+	1	113	c.112G>A	c.(112-114)Gaa>Aaa	p.E38K	PAX1_ENST00000398485.2_Intron|PAX1_ENST00000460221.1_Intron			P15863	PAX1_HUMAN	paired box 1	346					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						GTCACCTTTGGAAGTGCGCCT	0.672000													7	13					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40773305	40773305	+	Missense_Mutation	SNP	G	G	A	rs146060713		TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:40773305G>A	ENST00000602553.1	-	5	2264	c.1970C>T	c.(1969-1971)cCc>cTc	p.P657L	ZNF658_ENST00000377626.3_Missense_Mutation_p.P657L|ZNF658_ENST00000441795.1_Intron			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	657					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACATTCATAGGGTTTCTCCCC	0.423000													66	97					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1216926	1216926	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:1216926G>A	ENST00000304460.10	+	8	1095	c.1039G>A	c.(1039-1041)Ggg>Agg	p.G347R		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	347					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CCTCATCAACGGGTTCGACCT	0.652000													54	110					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2923836	2923836	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:2923836C>T	ENST00000254695.8	+	19	1788	c.1698C>T	c.(1696-1698)ctC>ctT	p.L566L	RAP1GAP2_ENST00000542807.1_Silent_p.L566L|RAP1GAP2_ENST00000366401.4_Silent_p.L551L|RAP1GAP2_ENST00000540393.2_Silent_p.L547L	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	566					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						GCTCGGGGCTCTTCCCCCGCC	0.632000													19	34					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40290939	40290939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr15:40290939C>T	ENST00000263791.5	+	20	2919	c.2876C>T	c.(2875-2877)tCg>tTg	p.S959L	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.S931L	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	959	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TAGCCCACTTCGCCTAAGTTT	0.348000													12	10					0	0	1	0	0
SMO	6608	broad.mit.edu	37	7	128850261	128850261	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:128850261G>A	ENST00000249373.3	+	9	1804	c.1524G>A	c.(1522-1524)gaG>gaA	p.E508E	RP11-286H14.8_ENST00000466717.1_RNA	NM_005631.4	NP_005622.1	Q99835	SMO_HUMAN	smoothened, frizzled family receptor	508					adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						CTGACTGTGAGATCAAGAATC	0.552000			Mis		skin basal cell						OREG0018305	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	70					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36776350	36776350	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:36776350C>T	ENST00000399881.3	+	23	2568	c.2531C>T	c.(2530-2532)cCa>cTa	p.P844L		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	844						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GAGGAGACTCCAGGTTACACA	0.373000													27	68					0	0	1	0	0
OR13C8	138802	broad.mit.edu	37	9	107331678	107331678	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:107331678C>T	ENST00000335040.1	+	1	230	c.230C>T	c.(229-231)tCt>tTt	p.S77F		NM_001004483.1	NP_001004483.1	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C, member 8	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|skin(1)	25						ACAAGTTCCTCTGTCCCACTA	0.443000													56	71					0	0	1	0	0
OR12D2	26529	broad.mit.edu	37	6	29364949	29364949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:29364949C>T	ENST00000383555.2	+	1	534	c.473C>T	c.(472-474)tCc>tTc	p.S158F	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						CTGCTGCACTCCGTAATGACT	0.483000													53	79					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52538855	52538855	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:52538855C>T	ENST00000321725.6	+	12	1416	c.1340C>T	c.(1339-1341)gCc>gTc	p.A447V		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	447	FAS1 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TGGACGCTGGCCGGGCAGGAG	0.602000													5	34					0	0	1	0	0
EIF3F	8665	broad.mit.edu	37	11	8008878	8008878	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:8008878C>T	ENST00000537635.1	+	1	442	c.24C>T	c.(22-24)tcC>tcT	p.S8S	EIF3F_ENST00000309828.4_5'UTR|EIF3F_ENST00000533626.1_5'UTR			O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3, subunit F	0						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)	13				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTTCCGCTTCCGCCTCCTTCT	0.547000											OREG0020726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	97	217					0	0	1	0	0
UGT2A2	574537	broad.mit.edu	37	4	70505092	70505092	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:70505092C>G	ENST00000457664.2	-	1	266	c.267G>C	c.(265-267)aaG>aaC	p.K89N	UGT2A1_ENST00000512704.1_Intron|UGT2A1_ENST00000286604.4_Intron|UGT2A1_ENST00000514019.1_Missense_Mutation_p.K290N|UGT2A1_ENST00000503640.1_Intron	NM_001105677.2	NP_001099147.2																					CTATATTGCTCTTCTTGTAGG	0.388000													29	69					0	0	1	0	0
AKAP3	10566	broad.mit.edu	37	12	4736271	4736271	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:4736271C>T	ENST00000545990.2	-	5	2321	c.1797G>A	c.(1795-1797)cgG>cgA	p.R599R	AKAP3_ENST00000228850.1_Silent_p.R599R	NM_001278309.1	NP_001265238.1	O75969	AKAP3_HUMAN	A kinase (PRKA) anchor protein 3	599					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|liver(1)|lung(17)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	51						TAAGTAAGTTCCGGATGAAAT	0.458000													28	89					0	0	1	0	0
SPOCK3	50859	broad.mit.edu	37	4	167658744	167658744	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:167658744G>A	ENST00000357154.3	-	11	1152	c.1015C>T	c.(1015-1017)Ccc>Tcc	p.P339S	SPOCK3_ENST00000421836.2_Missense_Mutation_p.P288S|SPOCK3_ENST00000357545.4_Missense_Mutation_p.P336S|SPOCK3_ENST00000512681.1_Missense_Mutation_p.P241S|SPOCK3_ENST00000506886.1_Missense_Mutation_p.P339S|SPOCK3_ENST00000507137.1_5'UTR|SPOCK3_ENST00000511531.1_Missense_Mutation_p.P339S|SPOCK3_ENST00000504953.1_Missense_Mutation_p.P336S|SPOCK3_ENST00000511269.1_Missense_Mutation_p.P336S|SPOCK3_ENST00000541354.1_Missense_Mutation_p.P219S|SPOCK3_ENST00000535728.1_Missense_Mutation_p.P207S|SPOCK3_ENST00000502330.1_Missense_Mutation_p.P339S|SPOCK3_ENST00000534949.1_Missense_Mutation_p.P243S|SPOCK3_ENST00000510741.1_Missense_Mutation_p.P296S|SPOCK3_ENST00000541637.1_Missense_Mutation_p.P241S	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	339	Thyroglobulin type-1.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		TCACACAGGGGGATATACTGT	0.428000													33	71					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63067088	63067088	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:63067088C>T	ENST00000544661.1	+	7	1020	c.592C>T	c.(592-594)Ctg>Ttg	p.L198L	SLC22A10_ENST00000332793.6_Silent_p.L353L|SLC22A10_ENST00000535888.1_Silent_p.L143L|SLC22A10_ENST00000525620.1_3'UTR|SLC22A10_ENST00000526800.1_Silent_p.L193L			Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	353						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GATCTGTATCCTGGTATTTTT	0.428000													11	22					0	0	1	0	0
FAM107A	11170	broad.mit.edu	37	3	58552978	58552978	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:58552978G>A	ENST00000394481.1	-	4	842	c.284C>T	c.(283-285)cCc>cTc	p.P95L	FAM107A_ENST00000464064.1_Missense_Mutation_p.P95L|FAM107A_ENST00000447756.2_Missense_Mutation_p.P123L|FAM107A_ENST00000360997.2_Missense_Mutation_p.P95L|FAM107A_ENST00000474531.1_Missense_Mutation_p.P126L	NM_007177.2	NP_009108.1	O95990	F107A_HUMAN	family with sequence similarity 107, member A	95					regulation of cell growth	nucleus	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(55;0.000189)|Kidney(10;0.000536)|KIRC - Kidney renal clear cell carcinoma(10;0.000716)|OV - Ovarian serous cystadenocarcinoma(275;0.154)		CTGCTCAAAGGGGCACTGCAG	0.637000													15	28					0	0	1	0	0
PKP4	8502	broad.mit.edu	37	2	159519815	159519815	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:159519815C>G	ENST00000389757.3	+	15	2560	c.2435C>G	c.(2434-2436)tCg>tGg	p.S812W	PKP4_ENST00000495123.1_3'UTR|AC005042.4_ENST00000342892.4_RNA|PKP4_ENST00000389759.3_Missense_Mutation_p.S812W	NM_001005476.1	NP_001005476.1	Q99569	PKP4_HUMAN	plakophilin 4	812					cell adhesion	desmosome	protein binding	p.S812L(1)		breast(2)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(21)|ovary(6)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	61						CCAGGACTGTCGAAGTCCCCC	0.483000										HNSCC(62;0.18)			7	43					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179498590	179498590	+	Silent	SNP	T	T	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:179498590T>C	ENST00000589042.1	-	231	42860	c.42636A>G	c.(42634-42636)aaA>aaG	p.K14212K	TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Silent_p.K12571K|TTN_ENST00000359218.5_Silent_p.K5272K|TTN_ENST00000342175.6_Silent_p.K5339K|TTN_ENST00000460472.2_Silent_p.K5147K|TTN_ENST00000342992.6_Silent_p.K11644K|TTN-AS1_ENST00000589487.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12571							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGACTTGAGCTTTTATCTGAG	0.428000													60	127					0	0	1	0	0
ITGB3	3690	broad.mit.edu	37	17	45384967	45384967	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:45384967A>G	ENST00000560629.1	+	14	2230	c.2230A>G	c.(2230-2232)Att>Gtt	p.I744V	ITGB3_ENST00000435993.2_Silent_p.K708K|RP11-290H9.4_ENST00000575039.1_RNA|ITGB3_ENST00000559488.1_Silent_p.K755K			P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0					activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	AATTCGCTAAATTTGAGGAAG	0.517000													19	32					0	0	1	0	0
DGCR2	9993	broad.mit.edu	37	22	19035969	19035969	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:19035969G>A	ENST00000263196.7	-	7	1237	c.990C>T	c.(988-990)ttC>ttT	p.F330F	DGCR2_ENST00000545799.1_3'UTR|DGCR2_ENST00000537045.1_Silent_p.F289F	NM_001184781.1|NM_005137.2	NP_001171710.1|NP_005128.1	P98153	IDD_HUMAN	DiGeorge syndrome critical region gene 2	330	VWFC.				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)	18	Colorectal(54;0.0993)					CCAGACACATGAACTTGCAGC	0.597000													92	181					0	0	1	0	0
TSC1	7248	broad.mit.edu	37	9	135797353	135797353	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:135797353C>T	ENST00000298552.3	-	7	737	c.516G>A	c.(514-516)gtG>gtA	p.V172V	TSC1_ENST00000403810.1_Silent_p.V172V|TSC1_ENST00000475903.1_5'UTR|TSC1_ENST00000440111.2_Silent_p.V172V|TSC1_ENST00000545250.1_Silent_p.V121V	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	172					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		AGACTTCCGCCACGTGGCCTA	0.488000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				32	52					0	0	1	0	0
SEMG2	6407	broad.mit.edu	37	20	43850353	43850353	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr20:43850353G>A	ENST00000372769.3	+	2	170	c.80G>A	c.(79-81)gGa>gAa	p.G27E		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	27					sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				TTACCAGGTGGATCAAAAGGC	0.393000													27	65					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130215792	130215792	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:130215792G>A	ENST00000276211.5	+	2	498	c.153G>A	c.(151-153)tcG>tcA	p.S51S	ARHGAP36_ENST00000370922.1_Silent_p.S39S	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	51					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						AGATGGTATCGATACACAGCC	0.532000													57	156					0	0	1	0	0
PACRG	135138	broad.mit.edu	37	6	163235304	163235304	+	Silent	SNP	C	C	T	rs76289683		TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:163235304C>T	ENST00000337019.3	+	3	506	c.282C>T	c.(280-282)atC>atT	p.I94I	PACRG_ENST00000366888.2_Silent_p.I94I|PACRG_ENST00000366889.2_Silent_p.I94I|PACRG_ENST00000542669.1_3'UTR	NM_152410.2	NP_689623.2	Q96M98	PACRG_HUMAN	PARK2 co-regulated	94										endometrium(2)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		GAAACAAAATCGCCTGGAAGG	0.478000													37	68					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65490353	65490353	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr15:65490353C>T	ENST00000261883.4	-	9	2437	c.2271G>A	c.(2269-2271)agG>agA	p.R757R		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	757					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						TCCGGTAGGCCCTCACCTTAA	0.532000													62	132					0	0	1	0	0
DAPK3	1613	broad.mit.edu	37	19	3964251	3964251	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:3964251C>T	ENST00000545797.2	-	4	787	c.544G>A	c.(544-546)Gag>Aag	p.E182K	DAPK3_ENST00000301264.3_Missense_Mutation_p.E182K			O43293	DAPK3_HUMAN	death-associated protein kinase 3	182	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|skin(2)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCACAAACTCCGGGGTGCCG	0.652000													10	15					0	0	1	0	0
FCRLA	84824	broad.mit.edu	37	1	161682926	161682926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:161682926C>T	ENST00000367959.2	+	6	1147	c.905C>T	c.(904-906)tCa>tTa	p.S302L	FCRLA_ENST00000470841.1_3'UTR|FCRLA_ENST00000349527.4_Missense_Mutation_p.S184L|FCRLA_ENST00000236938.6_Missense_Mutation_p.S296L|FCRLA_ENST00000309691.6_Missense_Mutation_p.S190L|FCRLA_ENST00000367953.3_Missense_Mutation_p.S285L|FCRLA_ENST00000350710.3_Missense_Mutation_p.S61L|FCRLA_ENST00000367949.2_Missense_Mutation_p.S112L|FCRLA_ENST00000367950.1_Missense_Mutation_p.S72L|FCRLA_ENST00000367957.2_Missense_Mutation_p.S156L|FCRLA_ENST00000294796.4_Missense_Mutation_p.S145L|FCRLA_ENST00000546024.1_Missense_Mutation_p.S207L|FCRLA_ENST00000540926.1_Missense_Mutation_p.S285L|FCRLA_ENST00000540521.1_Missense_Mutation_p.S162L	NM_001184866.1	NP_001171795.1	Q7L513	FCRLA_HUMAN	Fc receptor-like A	279	Pro-rich.				cell differentiation	cytoplasm|extracellular region				breast(1)|kidney(12)|large_intestine(4)|lung(13)|prostate(1)|skin(2)|stomach(1)	34	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			CCTCAGAAATCAGCTGCTCCA	0.577000													49	114					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57188088	57188088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:57188088C>T	ENST00000331162.4	-	5	1304	c.1034G>A	c.(1033-1035)aGa>aAa	p.R345K		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	345					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R345I(1)|p.R345T(1)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			AGTATGAATTCTCTTATGTCT	0.443000													5	36					0	0	1	0	0
ZUFSP	221302	broad.mit.edu	37	6	116988313	116988313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:116988313G>A	ENST00000368576.3	-	2	286	c.43C>T	c.(43-45)Cca>Tca	p.P15S	ZUFSP_ENST00000368573.1_Missense_Mutation_p.P15S|ZUFSP_ENST00000471919.1_Intron	NM_145062.2	NP_659499.2	Q96AP4	ZUFSP_HUMAN	zinc finger with UFM1-specific peptidase domain	15						intracellular	zinc ion binding			NS(1)|endometrium(2)|kidney(6)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	21				GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0368)|OV - Ovarian serous cystadenocarcinoma(136;0.0464)|Epithelial(106;0.186)		TTCATGTCTGGTTCTGAGGTT	0.328000													25	57					0	0	1	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64722946	64722946	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:64722946G>A	ENST00000338957.4	+	5	2435	c.2368G>A	c.(2368-2370)Gaa>Aaa	p.E790K	ZC3H12B_ENST00000423889.3_Missense_Mutation_p.E779K	NM_001010888.3	NP_001010888.3	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	779							endonuclease activity|nucleic acid binding|zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TATGATCCCAGAACACCAGTA	0.493000													30	69					0	0	1	0	0
HEATR4	399671	broad.mit.edu	37	14	73967417	73967417	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:73967417C>T	ENST00000553558.1	-	12	2444	c.2123G>A	c.(2122-2124)gGa>gAa	p.G708E	HEATR4_ENST00000334988.2_Missense_Mutation_p.G708E|HEATR4_ENST00000560393.1_Missense_Mutation_p.G661E	NM_001220484.1	NP_001207413.1			HEAT repeat containing 4											breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		CTGGGAATTTCCTTGACCTAG	0.498000													15	41					0	0	1	0	0
FAM154A	158297	broad.mit.edu	37	9	18928949	18928949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:18928949C>T	ENST00000380534.4	-	4	805	c.526G>A	c.(526-528)Gat>Aat	p.D176N	FAM154A_ENST00000542071.1_5'UTR|FAM154A_ENST00000380530.1_3'UTR	NM_153707.2	NP_714918.2	Q8IYX7	F154A_HUMAN	family with sequence similarity 154, member A	176										breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|skin(1)	26				GBM - Glioblastoma multiforme(50;6.53e-16)		ATGGGGTAATCGTCCTGGTGT	0.478000													25	27					0	0	1	0	0
FAM66D	100132923	broad.mit.edu	37	8	11986719	11986719	+	RNA	SNP	G	G	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:11986719G>C	ENST00000434078.2	+	0	608					NR_027425.1																						TGGATTTCAGGAAAAGCTGCA	0.522000													4	44					0	0	1	0	0
CPLX2	10814	broad.mit.edu	37	5	175306960	175306960	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:175306960G>A	ENST00000359546.4	+	5	960	c.317G>A	c.(316-318)gGg>gAg	p.G106E	CPLX2_ENST00000515094.1_Missense_Mutation_p.G106E|CPLX2_ENST00000393745.3_Missense_Mutation_p.G106E	NM_001008220.1|NM_006650.3	NP_001008221.1|NP_006641.1	Q6PUV4	CPLX2_HUMAN	complexin 2	106					mast cell degranulation|positive regulation of synaptic plasticity|vesicle docking involved in exocytosis	cytosol				endometrium(3)|kidney(2)|lung(3)|ovary(2)	10	all_cancers(89;0.004)|Renal(175;0.000269)|Lung NSC(126;0.00441)|all_lung(126;0.00747)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCGGGCTGCGGGGACGAGGAG	0.627000													8	21					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46653007	46653007	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:46653007G>A	ENST00000253255.5	-	1	6212	c.6213C>T	c.(6211-6213)ttC>ttT	p.F2071F		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	2071					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CATCGTAGAAGAATCTGGAAT	0.463000													19	45					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74043608	74043608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:74043608G>A	ENST00000409561.1	+	3	2379	c.2258G>A	c.(2257-2259)cGa>cAa	p.R753Q		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	753										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TACCCTGCTCGACCTGATTCT	0.552000													54	92					0	0	1	0	0
MYOZ3	91977	broad.mit.edu	37	5	150051338	150051338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:150051338G>A	ENST00000297130.4	+	5	491	c.292G>A	c.(292-294)Gag>Aag	p.E98K	CTC-345K18.2_ENST00000511626.2_RNA|MYOZ3_ENST00000517768.1_Missense_Mutation_p.E98K	NM_001122853.2|NM_133371.4	NP_001116325.1|NP_588612.2	Q8TDC0	MYOZ3_HUMAN	myozenin 3	98	Binding to FLNC.					sarcomere	protein binding			large_intestine(2)|lung(1)|skin(2)	5		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAATGGCCCTGAGGGGCCGAA	0.726000													11	31					0	0	1	0	0
SLC39A5	283375	broad.mit.edu	37	12	56629017	56629017	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:56629017G>A	ENST00000266980.4	+	5	1004	c.711G>A	c.(709-711)ctG>ctA	p.L237L	SLC39A5_ENST00000454355.2_Silent_p.L237L	NM_001135195.1	NP_001128667.1	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (zinc transporter), member 5	237					zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			NS(1)|cervix(6)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TGCGGCTCCTGGGACCTCGTC	0.627000													74	132					0	0	1	0	0
TUBD1	51174	broad.mit.edu	37	17	57955475	57955475	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:57955475C>T	ENST00000325752.3	-	5	1035	c.758G>A	c.(757-759)cGa>cAa	p.R253Q	TUBD1_ENST00000340993.6_Missense_Mutation_p.R253Q|TUBD1_ENST00000394239.3_Missense_Mutation_p.R253Q|TUBD1_ENST00000592426.1_Missense_Mutation_p.R253Q|TUBD1_ENST00000539018.1_Missense_Mutation_p.R37Q|TUBD1_ENST00000376094.4_Missense_Mutation_p.R253Q|TUBD1_ENST00000346141.6_Intron	NM_016261.3	NP_057345.2	Q9UJT1	TBD_HUMAN	tubulin, delta 1	253					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			NS(2)|breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(2)	21	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			TAGTGGATTTCGTCTGTAGTG	0.408000													11	46					0	0	1	0	0
INMT-FAM188B	100526825	broad.mit.edu	37	7	30793497	30793497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:30793497C>T	ENST00000458257.1	+	2	316	c.302C>T	c.(301-303)cCg>cTg	p.P101L	INMT_ENST00000013222.5_Missense_Mutation_p.P102L|INMT_ENST00000409539.1_Missense_Mutation_p.P101L|INMT_ENST00000484180.1_3'UTR																							AAGAAGGAGCCGGGGGCCTAT	0.572000													52	138					0	0	1	0	0
HUNK	30811	broad.mit.edu	37	21	33371051	33371051	+	Missense_Mutation	SNP	C	C	T	rs141493785	by1000genomes	TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr21:33371051C>T	ENST00000270112.2	+	11	2059	c.1699C>T	c.(1699-1701)Cgc>Tgc	p.R567C		NM_014586.1	NP_055401.1	P57058	HUNK_HUMAN	hormonally up-regulated Neu-associated kinase	567					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(2)|stomach(1)	30						GTCTGTGGATCGCGACGACCA	0.602000													12	42					0	0	1	0	0
MBNL2	10150	broad.mit.edu	37	13	98009818	98009818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr13:98009818C>T	ENST00000345429.6	+	6	1668	c.887C>T	c.(886-888)cCc>cTc	p.P296L	MBNL2_ENST00000376673.3_Missense_Mutation_p.P296L|MBNL2_ENST00000343600.4_Missense_Mutation_p.P296L|MBNL2_ENST00000445661.2_Missense_Mutation_p.P141L|MBNL2_ENST00000397601.1_Missense_Mutation_p.P296L	NM_144778.3	NP_659002.1	Q5VZF2	MBNL2_HUMAN	muscleblind-like splicing regulator 2	296					mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(7)|prostate(1)|skin(1)	17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			GTCTTTAACCCCAGCGTCTTG	0.522000													35	80					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29885256	29885256	+	Missense_Mutation	SNP	G	G	A	rs56916487		TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:29885256G>A	ENST00000310624.6	+	4	1660	c.1627G>A	c.(1627-1629)Gaa>Aaa	p.E543K		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	543	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						ATCCCCAGCCGAAGTCAAGTC	0.557000													25	62					0	0	1	0	0
NLGN1	22871	broad.mit.edu	37	3	173997067	173997067	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:173997067C>T	ENST00000457714.1	+	6	1705	c.1276C>T	c.(1276-1278)Cct>Tct	p.P426S	NLGN1_ENST00000361589.4_Missense_Mutation_p.P426S|NLGN1_ENST00000401917.3_Missense_Mutation_p.P466S|NLGN1_ENST00000466350.1_3'UTR|NLGN1_ENST00000545397.1_Missense_Mutation_p.P426S	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	443					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			ATATGGATATCCTGAAGGCAA	0.338000													21	50					0	0	1	0	0
ETV6	2120	broad.mit.edu	37	12	12022507	12022507	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:12022507C>T	ENST00000396373.4	+	5	887	c.613C>T	c.(613-615)Ctg>Ttg	p.L205L		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	205						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CCGGTCCCCCCTGGACAACAT	0.632000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								87	188					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37730652	37730652	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:37730652G>A	ENST00000330843.4	-	4	1680	c.1668C>T	c.(1666-1668)tcC>tcT	p.S556S	RAB11FIP1_ENST00000524118.1_Intron|RAB11FIP1_ENST00000287263.4_Intron|RAB11FIP1_ENST00000522727.1_Intron|RAB11FIP1_ENST00000523182.1_5'UTR	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	556	Ser-rich.				protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			AGTCAGTAGGGGAAGGAAGCC	0.537000													29	51					0	0	1	0	0
FGD1	2245	broad.mit.edu	37	X	54481899	54481899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:54481899G>A	ENST00000375135.3	-	12	2730	c.1997C>T	c.(1996-1998)tCc>tTc	p.S666F		NM_004463.2	NP_004454.2	P98174	FGD1_HUMAN	FYVE, RhoGEF and PH domain containing 1	666	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GAGCTCGAGGGAGCGCTGCTT	0.552000													4	30					0	0	1	0	0
INPP4A	3631	broad.mit.edu	37	2	99163138	99163138	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:99163138T>C	ENST00000074304.5	+	13	1537	c.1144T>C	c.(1144-1146)Ttt>Ctt	p.F382L	INPP4A_ENST00000409540.3_Missense_Mutation_p.F382L|INPP4A_ENST00000545415.1_Missense_Mutation_p.F382L|INPP4A_ENST00000409463.1_Intron|INPP4A_ENST00000409851.3_Missense_Mutation_p.F382L|INPP4A_ENST00000523221.1_Missense_Mutation_p.F382L|INPP4A_ENST00000409016.3_Missense_Mutation_p.F382L	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	382					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						GCTGCACAAATTTGAAGAGAC	0.433000													12	23					0	0	1	0	0
AFAP1	60312	broad.mit.edu	37	4	7811423	7811423	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:7811423G>A	ENST00000420658.1	-	9	1244	c.972C>T	c.(970-972)atC>atT	p.I324I	AFAP1_ENST00000358461.2_Silent_p.I324I|AFAP1_ENST00000382543.3_Silent_p.I324I|AFAP1_ENST00000360265.4_Silent_p.I324I	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	324						actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						TGATCTTGGTGATTTTTTTCC	0.483000													19	38					0	0	1	0	0
ANGPTL1	9068	broad.mit.edu	37	1	178820449	178820449	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:178820449T>A	ENST00000234816.2	-	6	1738	c.1291A>T	c.(1291-1293)Aac>Tac	p.N431Y	ANGPTL1_ENST00000367629.1_Missense_Mutation_p.N431Y|RALGPS2_ENST00000367634.2_Intron|RALGPS2_ENST00000367635.3_Intron|RALGPS2_ENST00000324778.4_Intron	NM_004673.3	NP_004664.1	O95841	ANGL1_HUMAN	angiopoietin-like 1	431	Fibrinogen C-terminal.					extracellular space	receptor binding			breast(2)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)	14						TGGGCGCAGTTTCCTTTGAGG	0.388000													19	45					0	0	1	0	0
ZNF248	57209	broad.mit.edu	37	10	38121086	38121086	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr10:38121086C>A	ENST00000395867.3	-	6	1747	c.1197G>T	c.(1195-1197)caG>caT	p.Q399H	ZNF248_ENST00000494133.1_Intron|ZNF248_ENST00000374648.3_Intron|ZNF248_ENST00000357328.4_Missense_Mutation_p.Q399H	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						TGTGTGTTCTCTGATGTTGAG	0.468000													31	49					7.72975e-29	7.88686e-29	1	1	0
BIRC6	57448	broad.mit.edu	37	2	32605261	32605261	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:32605261T>A	ENST00000421745.2	+	3	682	c.548T>A	c.(547-549)aTt>aAt	p.I183N		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	183					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					AAGGTAGATATTTCTAGTACA	0.313000													5	3					0	0	1	0	0
HSPA14	51182	broad.mit.edu	37	10	14896213	14896213	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr10:14896213T>G	ENST00000378372.3	+	9	1063	c.824T>G	c.(823-825)tTg>tGg	p.L275W		NM_016299.2	NP_057383.2	Q0VDF9	HSP7E_HUMAN	heat shock 70kDa protein 14	275					'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)	17						TTGTCAACCTTGGGAAGTGCC	0.348000													30	67					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73460543	73460543	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:73460543C>T	ENST00000252034.7	+	11	966	c.567C>T	c.(565-567)atC>atT	p.I189I	ELN_ENST00000445912.1_Silent_p.I189I|ELN_ENST00000380562.4_Silent_p.I189I|ELN_ENST00000380575.4_Silent_p.I179I|ELN_ENST00000380584.4_Silent_p.I189I|ELN_ENST00000380553.4_Silent_p.I86I|ELN_ENST00000414324.1_Silent_p.I184I|ELN_ENST00000320399.6_Silent_p.I189I|ELN_ENST00000380576.5_Silent_p.I189I|ELN_ENST00000358929.4_Silent_p.I189I|ELN_ENST00000429192.1_Silent_p.I194I|ELN_ENST00000320492.7_Intron|ELN_ENST00000458204.1_Silent_p.I179I|ELN_ENST00000357036.5_Silent_p.I194I	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	189					blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TTGCTGGAATCCCAGGTGAGG	0.602000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						29	74					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102920	22102920	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:22102920G>A	ENST00000542433.1	-	1	176	c.79C>T	c.(79-81)Cta>Tta	p.L27L		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		AGGCTTCTTAGATTTGGGGGG	0.488000													44	71					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18436161	18436161	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:18436161C>T	ENST00000338745.6	-	7	2733	c.999G>A	c.(997-999)gtG>gtA	p.V333V	SATB1_ENST00000454909.2_Silent_p.V333V|SATB1_ENST00000417717.2_Silent_p.V333V|TBC1D5_ENST00000414318.2_Intron	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	333					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						AAAGTCTATTCACTGCATACT	0.488000													42	48					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22005154	22005154	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:22005154G>A	ENST00000261200.4	-	22	2645	c.2646C>T	c.(2644-2646)atC>atT	p.I882I	ABCC9_ENST00000261201.4_Silent_p.I882I|ABCC9_ENST00000345162.2_Silent_p.I846I|RP11-729I10.2_ENST00000539874.1_RNA	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	882	ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TCATGGCTATGATCTAAGGAA	0.358000													12	17					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1220494	1220494	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:1220494G>T	ENST00000326873.7	+	4	1760	c.587G>T	c.(586-588)gGc>gTc	p.G196V		NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	196	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.Y156fs*87(4)|p.?(3)|p.G196V(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGACCTGGGCGTGGCCGAG	0.687000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			4	7					0.014758	0.0147874	1	1	0
C7orf57	136288	broad.mit.edu	37	7	48089491	48089491	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:48089491C>T	ENST00000348904.3	+	6	734	c.522C>T	c.(520-522)gcC>gcT	p.A174A	C7orf57_ENST00000435376.1_Silent_p.A52A|C7orf57_ENST00000420324.1_Silent_p.A219A|C7orf57_ENST00000539619.1_Silent_p.A174A|C7orf57_ENST00000430738.1_Silent_p.A219A	NM_001100159.2	NP_001093629.1	Q8NEG2	CG057_HUMAN	chromosome 7 open reading frame 57	174										breast(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	9						GGCTACCGGCCATTGACTCAA	0.483000													11	20					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70778357	70778357	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:70778357G>A	ENST00000322773.4	+	15	1315	c.1213G>A	c.(1213-1215)Gag>Aag	p.E405K	COL19A1_ENST00000393344.1_Missense_Mutation_p.E27K	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	405	Triple-helical region 2 (COL2).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						ACCTGGAAAAGAGGGTCAGAG	0.443000													15	40					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57372379	57372379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:57372379C>T	ENST00000361249.3	+	8	1232	c.1136C>T	c.(1135-1137)tCc>tTc	p.S379F		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	379	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex		p.S379F(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						TTTGGAGGCTCCTTGGGCATT	0.393000													44	45					0	0	1	0	0
FLVCR2	55640	broad.mit.edu	37	14	76045384	76045384	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:76045384G>A	ENST00000238667.4	+	1	425	c.69G>A	c.(67-69)gcG>gcA	p.A23A	AC007182.6_ENST00000455232.1_RNA	NM_017791.2	NP_060261.2	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular receptor family, member 2	23					transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15				BRCA - Breast invasive adenocarcinoma(234;0.029)		CACTCCAAGCGGACCCCAGCG	0.627000													33	92					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55045209	55045209	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:55045209C>T	ENST00000335056.3	+	3	367	c.329C>T	c.(328-330)tCc>tTc	p.S110F																	endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GAGAGCAACTCCCTGAAGATC	0.552000													15	15					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138421116	138421116	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:138421116A>T	ENST00000409968.1	+	26	4800	c.4622A>T	c.(4621-4623)aAa>aTa	p.K1541I	THSD7B_ENST00000413152.2_Missense_Mutation_p.K1513I|THSD7B_ENST00000272643.3_Missense_Mutation_p.K1544I					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GATATTTTTAAAGGATGGTCT	0.363000													9	8					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33635388	33635388	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr13:33635388G>A	ENST00000380099.3	+	4	2180	c.2172G>A	c.(2170-2172)ggG>ggA	p.G724G	KL_ENST00000426690.2_3'UTR|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	724	Glycosyl hydrolase-1 2.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		CTCAGAATGGGAAAATATCCA	0.463000													19	36					0	0	1	0	0
ZCCHC13	389874	broad.mit.edu	37	X	73524129	73524129	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:73524129G>A	ENST00000339534.2	+	1	105	c.28G>A	c.(28-30)Gga>Aga	p.G10R		NM_203303.2	NP_976048.1	Q8WW36	ZCH13_HUMAN	zinc finger, CCHC domain containing 13	10							nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	8						CTTCGCGTGTGGACACTCTGG	0.637000													6	11					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	75861016	75861016	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr13:75861016G>A	ENST00000377636.3	-	21	4155	c.3809C>T	c.(3808-3810)cCc>cTc	p.P1270L	TBC1D4_ENST00000425511.1_Missense_Mutation_p.P434L|TBC1D4_ENST00000431480.2_Missense_Mutation_p.P1262L|TBC1D4_ENST00000377625.2_Missense_Mutation_p.P1207L	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	1270						cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		AGCATCCGCGGGCAGCAGCTT	0.453000													19	44					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719148	140719148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:140719148G>A	ENST00000394576.2	+	1	610	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACCGCGAGGAAGAGGCTGT	0.597000													36	49					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736132	140736132	+	Silent	SNP	T	T	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:140736132T>A	ENST00000571252.1	+	1	1365	c.1365T>A	c.(1363-1365)gcT>gcA	p.A455A	PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCTCATGCTTCCTACTCTG	0.478000													29	95					0	0	1	0	0
ZBTB41	360023	broad.mit.edu	37	1	197168858	197168858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:197168858G>A	ENST00000367405.4	-	1	814	c.746C>T	c.(745-747)tCc>tTc	p.S249F	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						TCTTCTTGCGGAGAAACTTCT	0.378000													15	19					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119750046	119750046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:119750046G>A	ENST00000541757.1	+	16	1392	c.1012G>A	c.(1012-1014)Gaa>Aaa	p.E338K	MARCO_ENST00000327097.4_Missense_Mutation_p.E416K			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	416	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						AGAAAAAGGTGAAAGAGGTAA	0.433000													11	25					0	0	1	0	0
LMOD2	442721	broad.mit.edu	37	7	123296057	123296057	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:123296057G>A	ENST00000458573.2	+	1	197	c.40G>A	c.(40-42)Gaa>Aaa	p.E14K	LMOD2_ENST00000456238.2_Missense_Mutation_p.E14K	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	14	Glu-rich.|Tropomyosin-binding (By similarity).					cytoskeleton	actin binding|tropomyosin binding										CAGTAAATACGAATCCATCGA	0.537000													6	6					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57529513	57529513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:57529513C>T	ENST00000420713.1	+	4	1458	c.1346C>T	c.(1345-1347)tCa>tTa	p.S449L		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						ACCTTCTCCTCAACTCTAAAT	0.368000													8	12					0	0	1	0	0
MEPE	56955	broad.mit.edu	37	4	88766771	88766771	+	Missense_Mutation	SNP	G	G	A	rs150973660	by1000genomes	TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:88766771G>A	ENST00000497649.2	+	6	1057	c.679G>A	c.(679-681)Gat>Aat	p.D227N	MEPE_ENST00000395102.4_Missense_Mutation_p.D282N|MEPE_ENST00000508016.1_3'UTR|MEPE_ENST00000560249.1_Missense_Mutation_p.D138N|MEPE_ENST00000424957.3_Missense_Mutation_p.D251N|MEPE_ENST00000540395.1_Missense_Mutation_p.D138N|MEPE_ENST00000361056.3_Missense_Mutation_p.D251N			Q9NQ76	MEPE_HUMAN	matrix extracellular phosphoglycoprotein	251					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		AGGGGACAATGATATATCTCC	0.423000													20	63					0	0	1	0	0
FLVCR2	55640	broad.mit.edu	37	14	76045385	76045385	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:76045385G>A	ENST00000238667.4	+	1	426	c.70G>A	c.(70-72)Gac>Aac	p.D24N	AC007182.6_ENST00000455232.1_RNA	NM_017791.2	NP_060261.2	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular receptor family, member 2	24					transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15				BRCA - Breast invasive adenocarcinoma(234;0.029)		ACTCCAAGCGGACCCCAGCGT	0.632000													34	93					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78542698	78542698	+	Splice_Site	SNP	A	A	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:78542698A>T	ENST00000397909.2	+	22	4957	c.4785_splice	c.e22+1	p.N1595_splice	NAV3_ENST00000536525.2_Splice_Site_p.N1595_splice|NAV3_ENST00000266692.7_Splice_Site_p.N1418_splice|NAV3_ENST00000228327.6_Splice_Site_p.N1595_splice			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1595						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CTTTCAGCAAATGTAAGTCAC	0.308000										HNSCC(70;0.22)			10	23					0	0	1	0	0
NME7	29922	broad.mit.edu	37	1	169267804	169267804	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:169267804G>A	ENST00000367811.3	-	6	894	c.638C>T	c.(637-639)tCt>tTt	p.S213F	NME7_ENST00000472647.1_Missense_Mutation_p.S177F|NME7_ENST00000469474.1_5'UTR	NM_013330.3	NP_037462.1	Q9Y5B8	NDK7_HUMAN	NME/NM23 family member 7	213					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity	p.S213Y(1)		central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(8)|skin(1)	16	all_hematologic(923;0.208)					TCTGGCCGCAGAAGCAAAAGA	0.408000													35	75					0	0	1	0	0
PMS2P3	5387	broad.mit.edu	37	7	75140347	75140347	+	RNA	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:75140347G>A	ENST00000418756.1	-	0	1280					NR_028059.1															lung(1)	1						GTGGGGGTAGGGGGTTTCCTG	0.502000													39	92					0	0	1	0	0
SAP30	8819	broad.mit.edu	37	4	174292590	174292590	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:174292590G>A	ENST00000296504.3	+	1	497	c.257G>A	c.(256-258)aGc>aAc	p.S86N		NM_003864.3	NP_003855.1	O75446	SAP30_HUMAN	Sin3A-associated protein, 30kDa	86	Interaction with NCOR1 (By similarity).				transcription, DNA-dependent	histone deacetylase complex	DNA binding|metal ion binding|protein binding|transcription corepressor activity			large_intestine(1)|lung(2)|ovary(1)	4		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.15e-17)|Epithelial(43;4.33e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.62e-09)|STAD - Stomach adenocarcinoma(60;0.00278)|GBM - Glioblastoma multiforme(59;0.00659)|LUSC - Lung squamous cell carcinoma(193;0.0919)		GCCAGCTTCAGCAAGAGGATC	0.697000													29	47					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34149821	34149821	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:34149821G>A	ENST00000346193.3	-	1	626	c.575C>T	c.(574-576)cCc>cTc	p.P192L		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	192	Pro-rich.									NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						CGGAGTCTCGGGAGGCTTCAG	0.612000													31	45					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				12	52					0	0	1	0	0
ZNF280A	129025	broad.mit.edu	37	22	22869140	22869140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:22869140G>A	ENST00000302097.3	-	2	1067	c.815C>T	c.(814-816)cCc>cTc	p.P272L		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TAACACGATGGGATTTTCTTT	0.443000													36	71					0	0	1	0	0
RHAG	6005	broad.mit.edu	37	6	49578828	49578828	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:49578828C>T	ENST00000371175.4	-	7	1002	c.976G>A	c.(976-978)Gat>Aat	p.D326N	RHAG_ENST00000229810.7_Intron	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	326					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					CCACATGTATCATGGATCCTC	0.423000													21	51					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688982	26688982	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:26688982G>A	ENST00000529632.2	+	2	901	c.705G>A	c.(703-705)gaG>gaA	p.E235E	SEZ6L_ENST00000403121.1_Silent_p.E8E|SEZ6L_ENST00000360929.3_Silent_p.E235E|SEZ6L_ENST00000343706.4_Silent_p.E235E|SEZ6L_ENST00000404234.3_Silent_p.E235E|SEZ6L_ENST00000248933.6_Silent_p.E235E|SEZ6L_ENST00000402979.1_Silent_p.E8E	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	235						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CCCCCCAGGAGGACACCAGCC	0.632000													25	51					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130855736	130855736	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:130855736C>T	ENST00000245255.3	+	20	2609	c.2337C>T	c.(2335-2337)atC>atT	p.I779I	PIWIL1_ENST00000541480.1_3'UTR	NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	779	Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ACTTTTTTATCGTGAGCCAGG	0.438000													36	90					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730325	140730325	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:140730325A>C	ENST00000523390.1	+	1	498	c.498A>C	c.(496-498)ttA>ttC	p.L166F	PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACTGAAGTTATACACCATCA	0.428000													82	254					0	0	1	0	0
PRB1	5542	broad.mit.edu	37	12	11506765	11506765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:11506765C>T	ENST00000500254.2	-	3	309	c.272G>A	c.(271-273)cGa>cAa	p.R91Q	PRB1_ENST00000546254.1_Missense_Mutation_p.R91Q|PRB1_ENST00000545626.1_Missense_Mutation_p.R91Q	NM_005039.3|NM_199353.2	NP_005030.2|NP_955385.1	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1	274	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].					extracellular region				NS(1)|central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20			OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGAGGAGATCGGGGACTTCG	0.612000													142	748					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48805808	48805808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:48805808G>A	ENST00000314191.2	-	32	3792	c.3736C>T	c.(3736-3738)Cca>Tca	p.P1246S	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.P1246S	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	1247					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AGGCTGAATGGCCCCCGAAGT	0.607000								Non-homologous end-joining					3	14					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153175055	153175055	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:153175055G>A	ENST00000340592.5	+	14	2363	c.2290G>A	c.(2290-2292)Gtt>Att	p.V764I	GRIA1_ENST00000448073.4_Missense_Mutation_p.V774I|GRIA1_ENST00000518783.1_Intron|GRIA1_ENST00000521843.2_Intron|GRIA1_ENST00000285900.5_Intron|GRIA1_ENST00000518142.1_Intron	NM_001114183.1|NM_001258020.1	NP_001107655.1|NP_001244949.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	764					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AAACCTAGCGGTTTTGAAACT	0.418000													14	31					0	0	1	0	0
CYP26A1	1592	broad.mit.edu	37	10	94837047	94837047	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr10:94837047C>T	ENST00000371531.1	+	7	1651	c.1273C>T	c.(1273-1275)Cat>Tat	p.H425Y	CYP26A1_ENST00000394139.1_Missense_Mutation_p.H425Y|CYP26A1_ENST00000224356.4_Missense_Mutation_p.H494Y	NM_057157.2	NP_476498.1	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A, polypeptide 1	494					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16		Colorectal(252;0.122)				CACCCATTTCCATGGGGAAAT	0.413000													18	21					0	0	1	0	0
VPS9D1	9605	broad.mit.edu	37	16	89777111	89777111	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr16:89777111C>A	ENST00000561976.1	-	9	1308	c.931G>T	c.(931-933)Gag>Tag	p.E311*	VPS9D1_ENST00000389386.3_Nonsense_Mutation_p.E381*					VPS9 domain containing 1																		TCCAGGTCCTCGAACGAGCTG	0.701000													3	11					0.115264	0.115264	1	1	0
KANK2	25959	broad.mit.edu	37	19	11280856	11280856	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:11280856G>A	ENST00000432929.2	-	11	2664	c.2304C>T	c.(2302-2304)gcC>gcT	p.A768A	KANK2_ENST00000587317.1_5'UTR|KANK2_ENST00000589359.1_Silent_p.A768A|KANK2_ENST00000589894.1_Silent_p.A760A|KANK2_ENST00000586659.1_Silent_p.A760A|KANK2_ENST00000355150.5_Silent_p.A760A	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	760										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						CTGCCTCACAGGCCAGCAGGG	0.642000													29	45					0	0	1	0	0
SH2B1	25970	broad.mit.edu	37	16	28883938	28883938	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr16:28883938C>T	ENST00000337120.5	+	7	5100	c.1809C>T	c.(1807-1809)caC>caT	p.H603H	SH2B1_ENST00000545570.1_Silent_p.H293H|SH2B1_ENST00000359285.5_Silent_p.H603H|SH2B1_ENST00000322610.8_Silent_p.H603H|SH2B1_ENST00000538342.1_Silent_p.H267H|SH2B1_ENST00000563674.1_Intron|SH2B1_ENST00000395532.4_Silent_p.H603H	NM_001145812.1|NM_015503.2	NP_001139284.1|NP_056318.2	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1	603	SH2.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25						TGCTCGAGCACTTCCGGGTGC	0.607000													27	73					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91502142	91502142	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:91502142G>A	ENST00000266718.4	-	2	1069	c.615C>T	c.(613-615)gtC>gtT	p.V205V	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	205					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						TTAGAAGAGAGACAGGGAGAC	0.408000													37	103					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9459602	9459602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr20:9459602C>T	ENST00000378493.1	+	35	3509	c.3494C>T	c.(3493-3495)gCc>gTc	p.A1165V	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000378501.2_Silent_p.S1177S|PLCB4_ENST00000378473.3_Missense_Mutation_p.A1177V|PLCB4_ENST00000334005.3_Silent_p.S1177S|PLCB4_ENST00000278655.4_Missense_Mutation_p.A1165V|PLCB4_ENST00000414679.2_Missense_Mutation_p.A1177V			Q15147	PLCB4_HUMAN	phospholipase C, beta 4	1165					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AAATTGGAAGCCGAGATGGAC	0.448000													11	25					0	0	1	0	0
CABLES1	91768	broad.mit.edu	37	18	20837244	20837244	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr18:20837244C>T	ENST00000256925.7	+	10	1815	c.1815C>T	c.(1813-1815)ttC>ttT	p.F605F	CABLES1_ENST00000400473.2_Silent_p.F278F|CABLES1_ENST00000420687.2_Silent_p.F340F|RP11-17J14.2_ENST00000585184.1_RNA|TMEM241_ENST00000450466.2_Intron|CABLES1_ENST00000585061.1_Intron	NM_001100619.2	NP_001094089.1	Q8TDN4	CABL1_HUMAN	Cdk5 and Abl enzyme substrate 1	605					blood coagulation|cell cycle|cell division|regulation of cell cycle|regulation of cell division	cytosol|nucleus	cyclin-dependent protein kinase regulator activity|protein binding			breast(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|stomach(1)	11	all_cancers(21;0.000102)|all_epithelial(16;2.48e-06)|Lung NSC(20;0.00696)|all_lung(20;0.0197)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CCTTTGAATTCCCGGTGTTAG	0.488000													20	47					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210559392	210559392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:210559392C>T	ENST00000360351.4	+	7	3004	c.2498C>T	c.(2497-2499)tCa>tTa	p.S833L	MAP2_ENST00000447185.1_Missense_Mutation_p.S829L|MAP2_ENST00000361559.4_Intron|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000392194.1_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	833					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AGGAGGAAATCAGTCCCATCA	0.502000													45	76					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3229096	3229096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:3229096G>A	ENST00000217939.6	-	7	7302	c.7148C>T	c.(7147-7149)cCa>cTa	p.P2383L		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2383	Ig-like C2-type 8.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTTGTTGGTTGGGGACAACCA	0.522000													28	35					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62287510	62287510	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:62287510G>A	ENST00000378024.4	-	5	14653	c.14379C>T	c.(14377-14379)ttC>ttT	p.F4793F	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4793					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CTTCTCCTTTGAAGCCAGGCA	0.517000													98	200					0	0	1	0	0
CRY2	1408	broad.mit.edu	37	11	45891668	45891668	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:45891668C>T	ENST00000443527.2	+	8	1344	c.1322C>T	c.(1321-1323)tCc>tTc	p.S441F	CRY2_ENST00000417225.2_Missense_Mutation_p.S359F	NM_021117.3	NP_066940.2	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like)	420	FAD-binding.|Required for inhibition of CLOCK-ARNTL- mediated transcription (By similarity).				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(2)	15						ATGTGGCTGTCCTGCAGTGCT	0.567000													30	81					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118715983	118715983	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:118715983G>A	ENST00000376300.2	-	12	1100	c.963C>T	c.(961-963)tcC>tcT	p.S321S	CCDC93_ENST00000319432.5_Silent_p.S320S|CCDC93_ENST00000460781.1_5'UTR	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	321										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						GTTTGTTCAAGGAAATGACTT	0.408000													10	43					0	0	1	0	0
RHBDF1	64285	broad.mit.edu	37	16	111654	111654	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr16:111654C>G	ENST00000262316.6	-	9	1391	c.1249G>C	c.(1249-1251)Gtc>Ctc	p.V417L	RHBDF1_ENST00000454039.2_Missense_Mutation_p.V417L	NM_022450.3	NP_071895.3	Q96CC6	RHDF1_HUMAN	rhomboid 5 homolog 1 (Drosophila)	417					cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	18		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				AGGATGGTGACGAGCGAGTGC	0.682000													22	52					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21427477	21427477	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:21427477G>A	ENST00000307378.6	-	15	2439	c.1719C>T	c.(1717-1719)tcC>tcT	p.S573S	SLCO1A2_ENST00000537524.1_Silent_p.S441S|SLCO1A2_ENST00000458504.1_Silent_p.S441S|SLCO1A2_ENST00000452078.1_Silent_p.S573S	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	573					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						GTAAACATGTGGAATCCATTA	0.353000													24	35					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138644105	138644105	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:138644105G>A	ENST00000218099.2	+	8	1268	c.1261G>A	c.(1261-1263)Ggg>Agg	p.G421R	F9_ENST00000394090.2_Missense_Mutation_p.G383R	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	421	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity	p.G421R(2)		breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TGAAGTGGAAGGGACCAGTTT	0.438000													37	88					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83402013	83402013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:83402013G>A	ENST00000262752.2	-	5	401	c.394C>T	c.(394-396)Cat>Tat	p.H132Y	RPS6KA6_ENST00000543399.1_Missense_Mutation_p.H132Y	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	132	Protein kinase 1.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						ATAAATGGATGATTTACTTCC	0.274000													20	39					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18022438	18022438	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:18022438G>A	ENST00000205890.5	+	2	662	c.324G>A	c.(322-324)gtG>gtA	p.V108V		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	108	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					CCTTCATGGTGATCCGCTTCC	0.632000													7	12					0	0	1	0	0
SEC16B	89866	broad.mit.edu	37	1	177899040	177899040	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:177899040G>A	ENST00000308284.6	-	26	3225	c.3136C>T	c.(3136-3138)Cgg>Tgg	p.R1046W	SEC16B_ENST00000495165.1_5'UTR|RP4-798P15.3_ENST00000354921.2_5'UTR|RP4-798P15.3_ENST00000528461.1_3'UTR	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	1046					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						CGATTTGGCCGATTCAGGCTA	0.527000													17	19					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83128910	83128910	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:83128910G>T	ENST00000329312.4	+	4	1231	c.1194G>T	c.(1192-1194)aaG>aaT	p.K398N		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	398					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						ACAAGAAAAAGGATGCAAAGA	0.343000													7	11					8.12818e-05	8.17705e-05	1	1	0
LRRC37A6P	387646	broad.mit.edu	37	10	27538505	27538505	+	RNA	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr10:27538505C>T	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							CATTCTTCTTCAGGGGTGTAG	0.493000													62	136					0	0	1	0	0
BTN3A3	10384	broad.mit.edu	37	6	26444527	26444527	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:26444527T>C	ENST00000244519.2	+	4	671	c.428T>C	c.(427-429)gTt>gCt	p.V143A	BTN3A3_ENST00000361232.3_Missense_Mutation_p.V101A|BTN3A3_ENST00000339789.4_Missense_Mutation_p.V101A	NM_006994.4	NP_008925.1	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3	143						integral to membrane				cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30						GAGCTGAAGGTTGCAGGTGAG	0.488000													39	66					0	0	1	0	0
ERICH1	157697	broad.mit.edu	37	8	665915	665915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:665915G>A	ENST00000262109.7	-	2	192	c.115C>T	c.(115-117)Cca>Tca	p.P39S	ERICH1_ENST00000518277.1_5'UTR|ERICH1_ENST00000522706.1_Intron	NM_207332.1	NP_997215.1	Q86X53	ERIC1_HUMAN	glutamate-rich 1	39										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)	20		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		ACTTTCTTTGGTGGATTTTGG	0.498000													59	114					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62257209	62257209	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:62257209G>A	ENST00000474889.1	+	21	3538	c.3161G>A	c.(3160-3162)gGc>gAc	p.G1054D	PTPRG-AS1_ENST00000474795.1_RNA|PTPRG-AS1_ENST00000479018.1_RNA|PTPRG-AS1_ENST00000462497.1_RNA|PTPRG-AS1_ENST00000475371.1_RNA|PTPRG-AS1_ENST00000495542.1_RNA|PTPRG_ENST00000295874.10_Missense_Mutation_p.G1025D	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	1054	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		CCAGAAACGGGCCCTGTGTTG	0.527000													18	33					0	0	1	0	0
FAR1	84188	broad.mit.edu	37	11	13736124	13736124	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:13736124C>T	ENST00000354817.3	+	9	1168	c.1024C>T	c.(1024-1026)Cta>Tta	p.L342L	FAR1_ENST00000527202.1_3'UTR	NM_032228.5	NP_115604.1	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	342					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13						CAATGTAAATCTAACCTCCAA	0.423000													11	19					0	0	1	0	0
GLIS3	169792	broad.mit.edu	37	9	4118105	4118105	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:4118105G>A	ENST00000324333.10	-	3	1101	c.908C>T	c.(907-909)cCc>cTc	p.P303L	GLIS3_ENST00000381971.3_Missense_Mutation_p.P458L	NM_152629.3	NP_689842.3	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	303	Pro-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		Agggggtggggggcctggggg	0.736000													10	21					0	0	1	0	0
WFDC2	10406	broad.mit.edu	37	20	44108668	44108668	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr20:44108668C>T	ENST00000342873.3	+	1	590	c.157C>T	c.(157-159)Cct>Tct	p.P53S	WFDC2_ENST00000372676.3_Missense_Mutation_p.P104S|WFDC2_ENST00000339946.3_Missense_Mutation_p.P56S|WFDC2_ENST00000488143.1_3'UTR			Q14508	WFDC2_HUMAN	WAP four-disulfide core domain 2	104	WAP 1.				proteolysis|spermatogenesis	extracellular space	serine-type endopeptidase inhibitor activity			lung(1)	1		Myeloproliferative disorder(115;0.0122)				CAGCCAGTGTCCTGGCCAGAT	0.542000													61	118					0	0	1	0	0
NPAT	4863	broad.mit.edu	37	11	108064742	108064742	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:108064742G>A	ENST00000278612.8	-	3	264	c.159C>T	c.(157-159)tcC>tcT	p.S53S		NM_002519.2	NP_002510.2	Q14207	NPAT_HUMAN	nuclear protein, ataxia-telangiectasia locus	53	Interaction with MIZF.				positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		TTCCAAATAAGGACTGAAAAG	0.264000													3	12					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152383101	152383101	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:152383101G>A	ENST00000271835.3	-	3	519	c.457C>T	c.(457-459)Cag>Tag	p.Q153*	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	153	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCTGGGTCTGAACCCCAGGC	0.602000													77	203					0	0	1	0	0
TIMP4	7079	broad.mit.edu	37	3	12195890	12195890	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:12195890C>T	ENST00000287814.4	-	4	924	c.414G>A	c.(412-414)gaG>gaA	p.E138E	SYN2_ENST00000432424.2_RNA	NM_003256.3	NP_003247.1	Q99727	TIMP4_HUMAN	TIMP metallopeptidase inhibitor 4	138	NTR.						metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	11						AGGACAGGTCCTCCCAGGGCT	0.498000													12	71					0	0	1	0	0
IGHV4-39	28394	broad.mit.edu	37	14	106877724	106877724	+	RNA	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:106877724G>A	ENST00000390619.2	-	0	319																											GACTCTTGAGGGACGGGTTGT	0.552000													55	154					0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31285541	31285541	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:31285541C>G	ENST00000332585.6	+	7	1645	c.1541C>G	c.(1540-1542)cCc>cGc	p.P514R	OSBP2_ENST00000446658.2_Missense_Mutation_p.P513R|OSBP2_ENST00000403222.3_Missense_Mutation_p.P348R|OSBP2_ENST00000382310.3_Intron|OSBP2_ENST00000437268.2_Missense_Mutation_p.P256R|OSBP2_ENST00000407373.1_Missense_Mutation_p.P341R|OSBP2_ENST00000401475.1_Missense_Mutation_p.P147R|OSBP2_ENST00000535268.1_Missense_Mutation_p.P58R	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	514					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						GTCCGCATTCCCAACAAGCCC	0.602000													52	157					0	0	1	0	0
EML3	256364	broad.mit.edu	37	11	62375218	62375218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:62375218G>A	ENST00000394773.2	-	11	1589	c.1282C>T	c.(1282-1284)Cac>Tac	p.H428Y	EML3_ENST00000529309.1_Missense_Mutation_p.H428Y|EML3_ENST00000494176.2_Missense_Mutation_p.H400Y|EML3_ENST00000278845.4_Missense_Mutation_p.H429Y|EML3_ENST00000531557.1_Missense_Mutation_p.H211Y|EML3_ENST00000438258.1_Intron	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3	428						cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						AAGTGGACGTGAGATTTCCCA	0.537000													26	58					0	0	1	0	0
EML5	161436	broad.mit.edu	37	14	89168884	89168884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:89168884C>T	ENST00000554922.1	-	14	2392	c.2144G>A	c.(2143-2145)cGa>cAa	p.R715Q	EML5_ENST00000380664.5_Missense_Mutation_p.R715Q|EML5_ENST00000352093.5_Missense_Mutation_p.R715Q	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	715						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GTTTTGCTGTCGATTATAAAT	0.393000													14	24					0	0	1	0	0
GOLGA5	9950	broad.mit.edu	37	14	93275750	93275750	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:93275750C>A	ENST00000163416.2	+	4	1134	c.878C>A	c.(877-879)gCt>gAt	p.A293D	GOLGA5_ENST00000355976.2_Missense_Mutation_p.A293D	NM_005113.2	NP_005104.2	Q8TBA6	GOGA5_HUMAN	golgin A5	293					Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			large_intestine(6)|lung(1)|ovary(2)	9		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		CTGACTGAAGCTGTGGCTGCA	0.488000			T	RET	papillary thyroid								18	70					1.01871e-10	1.02896e-10	1	1	0
OTOP3	347741	broad.mit.edu	37	17	72943148	72943148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:72943148G>A	ENST00000328801.4	+	6	1198	c.1198G>A	c.(1198-1200)Gag>Aag	p.E400K		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	400						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					ACACGGGCTGGAGGAGAGAGA	0.592000													21	48					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58298922	58298922	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr13:58298922C>T	ENST00000377918.3	+	4	3000	c.2974C>T	c.(2974-2976)Ccc>Tcc	p.P992S		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	992					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AACTGTGAATCCCACTGGGAA	0.418000													20	56					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128490051	128490051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:128490051G>A	ENST00000325888.8	+	31	5482	c.5221G>A	c.(5221-5223)Gag>Aag	p.E1741K	FLNC_ENST00000346177.6_Intron	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1741	Hinge 1.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CCTGCCGCACGAGGAGGAGCC	0.711000													3	10					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121744159	121744159	+	Silent	SNP	G	G	A	rs142856393	byFrequency	TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:121744159G>A	ENST00000452319.1	+	13	2322	c.2262G>A	c.(2260-2262)cgG>cgA	p.R754R	GLI2_ENST00000314490.11_Silent_p.R426R|GLI2_ENST00000361492.4_Silent_p.R754R			P10070	GLI2_HUMAN	GLI family zinc finger 2	754					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CACACACGCGGAACACCAAGC	0.597000													14	39					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75853081	75853081	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:75853081G>A	ENST00000322507.8	-	26	5023	c.4714C>T	c.(4714-4716)Ctg>Ttg	p.L1572L	COL12A1_ENST00000345356.6_Silent_p.L408L|COL12A1_ENST00000483888.2_Silent_p.L1572L|COL12A1_ENST00000416123.2_Silent_p.L1572L	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1572	Fibronectin type-III 11.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CTGAGTTTCAGATCCTGAGGT	0.428000													13	30					0	0	1	0	0
GRB10	2887	broad.mit.edu	37	7	50737506	50737506	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:50737506G>A	ENST00000403097.1	-	6	1179	c.399C>T	c.(397-399)ccC>ccT	p.P133P	GRB10_ENST00000357271.5_Silent_p.P139P|GRB10_ENST00000439599.1_Silent_p.P133P|GRB10_ENST00000402497.1_Silent_p.P81P|GRB10_ENST00000335866.3_Silent_p.P81P|GRB10_ENST00000402578.1_Silent_p.P81P|GRB10_ENST00000407526.1_Silent_p.P81P|GRB10_ENST00000398810.2_Silent_p.P81P|GRB10_ENST00000398812.2_Silent_p.P139P|GRB10_ENST00000401949.1_Silent_p.P139P|GRB10_ENST00000406641.1_Silent_p.P81P			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	139					insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					GAAAAGGATTGGGGATGGCCG	0.602000									Russell-Silver syndrome				8	21					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15818851	15818851	+	Splice_Site	SNP	T	T	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr16:15818851T>C	ENST00000338282.6	-	29	3965		c.e29-2		NDE1_ENST00000342673.5_3'UTR|MYH11_ENST00000300036.5_Splice_Site|MYH11_ENST00000576790.1_Splice_Site|MYH11_ENST00000452625.2_Splice_Site|MYH11_ENST00000396324.3_Splice_Site|NDE1_ENST00000571896.1_3'UTR|NDE1_ENST00000396354.1_3'UTR|NDE1_ENST00000396355.1_3'UTR	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle						axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						AACTTCATTCTAAGGGTGCCA	0.527000			T	CBFB	AML								5	19					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54806762	54806762	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:54806762G>A	ENST00000306858.7	+	5	3109	c.2993G>A	c.(2992-2994)gGa>gAa	p.G998E		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	998										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					AAGTTTCGAGGATTTATGCAA	0.348000													14	34					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77282817	77282817	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:77282817G>A	ENST00000376896.2	+	8	1723	c.1111_splice	c.e8+1	p.D371_splice	RORB_ENST00000396204.2_Splice_Site_p.D382_splice	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	382	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						GATATCTCCAGGTAGGGCAGT	0.403000													4	50					0	0	1	0	0
ZNF595	152687	broad.mit.edu	37	4	59442	59442	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:59442C>T	ENST00000509152.2	+	2	308	c.123C>T	c.(121-123)gtC>gtT	p.V41V	ZNF595_ENST00000526473.2_Silent_p.V41V|ZNF595_ENST00000339368.6_3'UTR					zinc finger protein 595											endometrium(5)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)	20		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		GGAACCTGGTCTCCCTGGGTG	0.433000													24	559					0	0	1	0	0
KLHL38	340359	broad.mit.edu	37	8	124664134	124664134	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:124664134C>T	ENST00000325995.7	-	1	1056	c.1033G>A	c.(1033-1035)Ggg>Agg	p.G345R	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	345										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						AGACTCCTCCCTGAGCTGACA	0.587000													51	56					0	0	1	0	0
ACSS1	84532	broad.mit.edu	37	20	25003716	25003716	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr20:25003716C>A	ENST00000537502.1	-	3	2102	c.571G>T	c.(571-573)Gag>Tag	p.E191*	ACSS1_ENST00000323482.4_Nonsense_Mutation_p.E274*|ACSS1_ENST00000432802.2_Nonsense_Mutation_p.E274*|ACSS1_ENST00000542618.1_Nonsense_Mutation_p.E153*			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	274					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	ACAGGGTCCTCCTTGGCCATT	0.602000													10	18					0.000673444	0.000676138	1	1	0
GRB7	2886	broad.mit.edu	37	17	37899506	37899506	+	Silent	SNP	C	C	T	rs149753893		TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:37899506C>T	ENST00000309156.4	+	5	794	c.537C>T	c.(535-537)ttC>ttT	p.F179F	GRB7_ENST00000394209.2_Silent_p.F179F|GRB7_ENST00000309185.3_Silent_p.F179F|GRB7_ENST00000394204.1_Silent_p.F179F|GRB7_ENST00000394211.3_Silent_p.F179F|GRB7_ENST00000445327.2_Silent_p.F202F|GRB7_ENST00000578702.1_3'UTR	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	179	Ras-associating.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			ATAGCCGCTTCGTCTTCCGGA	0.612000													21	61					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303864	151303864	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:151303864C>T	ENST00000370323.4	-	4	545	c.229G>A	c.(229-231)Gat>Aat	p.D77N	MAGEA10_ENST00000244096.3_Missense_Mutation_p.D77N|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	77										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GTCTCATCATCAGCAGAAACC	0.542000													83	169					0	0	1	0	0
E2F4	1874	broad.mit.edu	37	16	67228866	67228866	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr16:67228866C>T	ENST00000379378.3	+	6	850	c.791C>T	c.(790-792)cCa>cTa	p.P264L		NM_001950.3	NP_001941.2	Q16254	E2F4_HUMAN	E2F transcription factor 4, p107/p130-binding	264					G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(4)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)	11		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000697)|Epithelial(162;0.00303)|all cancers(182;0.0325)		ATGGCTGGCCCAGCAGCTGAG	0.577000													6	32					0	0	1	0	0
MVK	4598	broad.mit.edu	37	12	110013874	110013874	+	Silent	SNP	C	C	T	rs104895327		TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:110013874C>T	ENST00000228510.3	+	3	226	c.150C>T	c.(148-150)gaC>gaT	p.D50D	MVK_ENST00000535044.1_3'UTR|MVK_ENST00000541384.1_5'UTR|MVK_ENST00000539696.1_Intron|MVK_ENST00000539575.1_Silent_p.D50D|MVK_ENST00000392727.3_Silent_p.D50D	NM_000431.2|NM_001114185.1	NP_000422.1|NP_001107657.1	Q03426	KIME_HUMAN	mevalonate kinase	50					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|peroxisome	ATP binding|identical protein binding|mevalonate kinase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	8						GGAAAGTGGACCTCAGCTTAC	0.498000													23	58					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50271986	50271986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr15:50271986C>T	ENST00000284509.6	-	12	1003	c.862G>A	c.(862-864)Gga>Aga	p.G288R	ATP8B4_ENST00000559829.1_Missense_Mutation_p.G288R|ATP8B4_ENST00000558959.1_Intron	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	288					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		AGAATAATTCCCAAGCATATC	0.358000													16	21					0	0	1	0	0
FAM155B	27112	broad.mit.edu	37	X	68725707	68725707	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:68725707C>T	ENST00000252338.4	+	1	624	c.582C>T	c.(580-582)ttC>ttT	p.F194F		NM_015686.2	NP_056501.2	O75949	F155B_HUMAN	family with sequence similarity 155, member B	194						integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)	16						TTCGGAACTTCACTCTCTCCT	0.637000													29	64					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57931768	57931768	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr16:57931768G>A	ENST00000564448.1	-	30	3069	c.3009C>T	c.(3007-3009)gtC>gtT	p.V1003V	CNGB1_ENST00000251102.8_Silent_p.V1009V			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	1009					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						GGCCGCCCAAGACCTGCACTT	0.547000													62	161					0	0	1	0	0
ARF6	382	broad.mit.edu	37	14	50360612	50360612	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:50360612C>T	ENST00000298316.5	+	2	705	c.158C>T	c.(157-159)aCt>aTt	p.T53I		NM_001663.3	NP_001654.1	P62330	ARF6_HUMAN	ADP-ribosylation factor 6	53					cell adhesion|cellular component movement|cortical actin cytoskeleton organization|negative regulation of receptor-mediated endocytosis|positive regulation of actin filament polymerization|positive regulation of establishment of protein localization in plasma membrane|protein localization at cell surface|protein transport|regulation of dendritic spine development|regulation of filopodium assembly|regulation of Rac protein signal transduction|ruffle organization|small GTPase mediated signal transduction|vesicle-mediated transport	cell cortex|endosome membrane|filopodium membrane|Golgi apparatus|membrane fraction|ruffle	GTP binding|GTPase activity|thioesterase binding			endometrium(1)|kidney(1)|large_intestine(1)|ovary(1)	4	all_epithelial(31;0.000822)|Breast(41;0.0117)					GAGACGGTGACTTACAAAAAT	0.562000													18	36					0	0	1	0	0
BPIFA2	140683	broad.mit.edu	37	20	31761953	31761953	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr20:31761953A>C	ENST00000253362.2	+	4	517	c.371A>C	c.(370-372)aAc>aCc	p.N124T	BPIFA2_ENST00000354932.5_Missense_Mutation_p.N124T			Q96DR5	SPLC2_HUMAN	BPI fold containing family A, member 2	124						extracellular region	lipid binding										AAAGGCCTTAACCTGAGCTTC	0.517000													30	86					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1081704	1081704	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:1081704G>A	ENST00000264930.5	-	9	1328	c.1285C>T	c.(1285-1287)Cct>Tct	p.P429S		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	429					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GTCACGGAAGGGAAGTAGATG	0.622000													17	51					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17700783	17700783	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:17700783C>T	ENST00000353383.1	+	3	4990	c.4521C>T	c.(4519-4521)gcC>gcT	p.A1507A	RAI1_ENST00000261641.6_Silent_p.A1507A	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1507						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		TGGGCCTGGCCTCCCAGCCCC	0.642000													23	45					0	0	1	0	0
STRA6	64220	broad.mit.edu	37	15	74481511	74481511	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr15:74481511G>A	ENST00000323940.5	-	12	1280	c.1035C>T	c.(1033-1035)tcC>tcT	p.S345S	STRA6_ENST00000449139.2_Silent_p.S345S|STRA6_ENST00000574439.1_5'UTR|STRA6_ENST00000423167.2_Silent_p.S336S|STRA6_ENST00000395105.4_Silent_p.S345S|STRA6_ENST00000535552.1_Silent_p.S382S|STRA6_ENST00000563965.1_Silent_p.S384S|STRA6_ENST00000574278.1_Silent_p.S360S|STRA6_ENST00000416286.3_Silent_p.S337S	NM_001142617.1|NM_001142618.1|NM_001142619.1	NP_001136089.1|NP_001136090.1|NP_001136091.1	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid 6	345					adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(5)|skin(1)|stomach(2)	26						GCTTGTCCTCGGAGAGCACGA	0.622000													13	20					0	0	1	0	0
HCFC1	3054	broad.mit.edu	37	X	153223312	153223312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:153223312G>A	ENST00000310441.7	-	12	3020	c.2054C>T	c.(2053-2055)tCg>tTg	p.S685L	HCFC1_ENST00000369984.4_Missense_Mutation_p.S685L|HCFC1_ENST00000354233.3_Missense_Mutation_p.S616L	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	685	Interaction with SIN3A.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGGACCACCGACATCACTTT	0.532000													28	80					0	0	1	0	0
SELL	6402	broad.mit.edu	37	1	169672428	169672428	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:169672428C>T	ENST00000236147.4	-	6	1119	c.959G>A	c.(958-960)gGa>gAa	p.G320E	C1orf112_ENST00000498289.1_Intron|SELL_ENST00000463108.1_5'UTR	NM_000655.4	NP_000646.2	P14151	LYAM1_HUMAN	selectin L	307					blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	15	all_hematologic(923;0.208)					TGACCAGATTCCAGATGATTC	0.423000													3	16					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228474636	228474636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:228474636G>A	ENST00000570156.2	+	40	10801	c.10727G>A	c.(10726-10728)gGc>gAc	p.G3576D	OBSCN_ENST00000359599.6_Missense_Mutation_p.G1994D|OBSCN_ENST00000284548.11_Missense_Mutation_p.G3147D|OBSCN_ENST00000366709.4_Missense_Mutation_p.G266D|OBSCN_ENST00000366707.4_Missense_Mutation_p.G266D|OBSCN_ENST00000422127.1_Missense_Mutation_p.G3147D	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2609	Ig-like 36.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGCCATGAGGGCCACCGGGCC	0.662000													7	16					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35691271	35691271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:35691271C>T	ENST00000440995.2	+	11	1657	c.1657C>T	c.(1657-1659)Cct>Tct	p.P553S	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Missense_Mutation_p.P553S|SPEF2_ENST00000509059.1_Missense_Mutation_p.P553S			Q9C093	SPEF2_HUMAN	sperm flagellar 2	553					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATCAACAACACCTGAATTACC	0.388000													27	81					0	0	1	0	0
RABGAP1L	9910	broad.mit.edu	37	1	174606561	174606561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:174606561C>T	ENST00000251507.4	+	14	1933	c.1759C>T	c.(1759-1761)Ccc>Tcc	p.P587S		NM_014857.4	NP_055672.3	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like	587	Rab-GAP TBC.				regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			NS(1)|breast(2)|endometrium(4)|kidney(5)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(2)	45						TCGTACATTTCCCGCACATGA	0.358000													25	70					0	0	1	0	0
OCM	654231	broad.mit.edu	37	7	5923527	5923527	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:5923527C>T	ENST00000242104.5	+	3	293	c.201C>T	c.(199-201)ttC>ttT	p.F67F	OCM_ENST00000416608.1_Silent_p.F67F	NM_001097622.1	NP_001091091.1	P0CE72	ONCO_HUMAN	oncomodulin	67	EF-hand 1.						calcium ion binding			endometrium(1)|large_intestine(3)|lung(2)	6		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0978)|OV - Ovarian serous cystadenocarcinoma(56;2.11e-14)		GTAGGTTTTTCCTCCAGAAGT	0.428000													9	16					0	0	1	0	0
KCNK18	338567	broad.mit.edu	37	10	118969155	118969155	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr10:118969155G>A	ENST00000334549.1	+	3	500	c.500G>A	c.(499-501)cGa>cAa	p.R167Q		NM_181840.1	NP_862823.1	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	167						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	41		Colorectal(252;0.19)		all cancers(201;0.0211)		AATCGGTTCCGAAAATTCCCT	0.507000													37	53					0	0	1	0	0
EPS8L1	54869	broad.mit.edu	37	19	55593919	55593919	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:55593919C>T	ENST00000201647.6	+	12	1219	c.1163C>T	c.(1162-1164)cCa>cTa	p.P388L	EPS8L1_ENST00000586329.1_Missense_Mutation_p.P370L|EPS8L1_ENST00000245618.5_Missense_Mutation_p.P261L|EPS8L1_ENST00000540810.1_Missense_Mutation_p.P324L|EPS8L1_ENST00000592824.1_3'UTR|EPS8L1_ENST00000588359.1_Missense_Mutation_p.P42L	NM_133180.2	NP_573441.2	Q8TE68	ES8L1_HUMAN	EPS8-like 1	388						cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|prostate(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		AACGTCACTCCACGTGAAAAC	0.677000													4	3					0	0	1	0	0
CDR1	1038	broad.mit.edu	37	X	139866313	139866313	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:139866313C>T	ENST00000370532.2	-	1	410	c.219G>A	c.(217-219)atG>atA	p.M73I		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	73	23 X 6 AA approximate repeats.									breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CCCTCAAATCCATAGCTTCCG	0.453000													51	99					0	0	1	0	0
PGM1	5236	broad.mit.edu	37	1	64089270	64089270	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:64089270T>C	ENST00000371083.4	+	1	507	c.139T>C	c.(139-141)Ttt>Ctt	p.F47L	PGM1_ENST00000371084.3_Intron|PGM1_ENST00000540265.1_Intron	NM_001172818.1	NP_001166289.1	P36871	PGM1_HUMAN	phosphoglucomutase 1	29					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20						AACCTATTATTTTGAGGAAAA	0.428000													19	34					0	0	1	0	0
FDXR	2232	broad.mit.edu	37	17	72863070	72863070	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:72863070C>T	ENST00000442102.2	-	3	321	c.235G>A	c.(235-237)Gaa>Aaa	p.E79K	FDXR_ENST00000544854.1_Intron|FDXR_ENST00000420580.2_Intron|FDXR_ENST00000455107.2_Intron|FDXR_ENST00000583917.1_Intron|FDXR_ENST00000293195.5_Intron|FDXR_ENST00000582944.1_Intron|FDXR_ENST00000581969.1_Intron|FDXR_ENST00000581530.1_Intron|FDXR_ENST00000413947.2_Intron	NM_001258012.1	NP_001244941.1	P22570	ADRO_HUMAN	ferredoxin reductase	59					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					TCCTCCCCTTCCCCAGACAGA	0.637000													5	0					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7847156	7847156	+	Missense_Mutation	SNP	G	G	A	rs117218570	by1000genomes	TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:7847156G>A	ENST00000328375.1	-	1	363	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCCACATAGCGATCATAGGCC	0.557000													35	88					0	0	1	0	0
RSAD1	55316	broad.mit.edu	37	17	48559536	48559536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:48559536C>T	ENST00000258955.2	+	4	644	c.559C>T	c.(559-561)Ctc>Ttc	p.L187F		NM_018346.1	NP_060816.1	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing 1	187					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GGCCCGGCGCCTCTTTCCCGG	0.662000											OREG0024567	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	62					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90438745	90438745	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:90438745C>T	ENST00000369393.3	-	36	5369	c.5254G>A	c.(5254-5256)Gag>Aag	p.E1752K	MDN1_ENST00000428876.1_Missense_Mutation_p.E1752K			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1752					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GGGGAACCCTCCAGGAGAATG	0.468000													19	40					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248367224	248367224	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:248367224G>A	ENST00000456743.1	+	1	893	c.855G>A	c.(853-855)ttG>ttA	p.L285L		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTCCCATGTTGAATCCCCTCA	0.478000													56	87					0	0	1	0	0
SLFN5	162394	broad.mit.edu	37	17	33585883	33585883	+	Silent	SNP	C	C	T	rs138878596	by1000genomes	TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:33585883C>T	ENST00000299977.4	+	2	322	c.174C>T	c.(172-174)atC>atT	p.I58I	SLFN5_ENST00000592325.1_Silent_p.I58I|SLFN5_ENST00000542451.1_Silent_p.I58I	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	58					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		GGGGCATAATCAAGGCTGAGA	0.478000													37	77					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793414	65793414	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:65793414C>T	ENST00000312106.5	-	1	574	c.437G>A	c.(436-438)gGg>gAg	p.G146E		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	146	His-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						ATGGTGAGACCCCCTATGGTA	0.557000													21	31					0	0	1	0	0
C12orf71	728858	broad.mit.edu	37	12	27235017	27235017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:27235017G>A	ENST00000429849.2	-	1	430	c.400C>T	c.(400-402)Ctt>Ttt	p.L134F		NM_001080406.1	NP_001073875.1	A8MTZ7	CL071_HUMAN	chromosome 12 open reading frame 71	134										endometrium(2)|large_intestine(1)|lung(4)|skin(1)	8						TCTTGCACAAGATTATTCAGT	0.413000													3	9					0	0	1	0	0
IGKV6D-21	28870	broad.mit.edu	37	2	90060923	90060923	+	RNA	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:90060923C>T	ENST00000436451.2	+	0	337																											GGACAGATTTCACCCTCACCA	0.483000													44	98					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22749320	22749320	+	RNA	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:22749320G>A	ENST00000511446.1	+	0	691				GBA3_ENST00000503442.1_RNA|GBA3_ENST00000508166.1_RNA	NM_001277225.1	NP_001264154.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GGTCTGGTTGGAACCAGCAGA	0.433000													57	116					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159653921	159653921	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:159653921G>A	ENST00000297267.9	+	11	2577	c.2377G>A	c.(2377-2379)Gat>Aat	p.D793N	FNDC1_ENST00000340366.6_Missense_Mutation_p.D730N	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	793						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CGGTGACGGCGATAGGGAAGA	0.632000													12	19					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17700781	17700781	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:17700781G>T	ENST00000353383.1	+	3	4988	c.4519G>T	c.(4519-4521)Gcc>Tcc	p.A1507S	RAI1_ENST00000261641.6_Missense_Mutation_p.A1507S	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1507						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		GCTGGGCCTGGCCTCCCAGCC	0.647000													22	44					1.55795e-14	1.57998e-14	1	1	0
OR2T3	343173	broad.mit.edu	37	1	248637521	248637521	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:248637521G>A	ENST00000359594.2	+	1	895	c.870G>A	c.(868-870)ctG>ctA	p.L290L		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTCCTGTGCTGAACCCCCTCA	0.498000													35	243					0	0	1	0	0
OR12D2	26529	broad.mit.edu	37	6	29364950	29364950	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:29364950C>T	ENST00000383555.2	+	1	535	c.474C>T	c.(472-474)tcC>tcT	p.S158S	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						TGCTGCACTCCGTAATGACTT	0.488000													52	81					0	0	1	0	0
CDHR4	389118	broad.mit.edu	37	3	49836761	49836761	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:49836761C>T	ENST00000412678.2	-	2	167	c.159G>A	c.(157-159)ctG>ctA	p.L53L	CDHR4_ENST00000487256.1_Silent_p.L53L|CDHR4_ENST00000343366.4_Silent_p.L53L	NM_001007540.2	NP_001007541.2	A6H8M9	CDHR4_HUMAN	cadherin-related family member 4	53					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(3)	11						TGAGCAACTCCAGGGTGGGTG	0.567000													6	14					0	0	1	0	0
CEBPE	1053	broad.mit.edu	37	14	23587926	23587926	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:23587926C>T	ENST00000206513.5	-	1	899	c.375G>A	c.(373-375)cgG>cgA	p.R125R		NM_001805.3	NP_001796.2	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein (C/EBP), epsilon	125						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)	9	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		CCTCTGGCCCCCGGGGCTCCT	0.672000													8	19					0	0	1	0	0
UBE2Q2	92912	broad.mit.edu	37	15	76146731	76146731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr15:76146731C>T	ENST00000267938.4	+	2	567	c.185C>T	c.(184-186)tCc>tTc	p.S62F	UBE2Q2_ENST00000562635.1_3'UTR|UBE2Q2_ENST00000338677.4_Missense_Mutation_p.S62F|UBE2Q2_ENST00000561851.1_Missense_Mutation_p.S46F|UBE2Q2_ENST00000569423.1_Missense_Mutation_p.S62F	NM_173469.2	NP_775740.1	Q8WVN8	UB2Q2_HUMAN	ubiquitin-conjugating enzyme E2Q family member 2	62					protein K48-linked ubiquitination	cytoplasm	ATP binding|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	12						AAACAGGAATCCTATCCATCT	0.378000													7	27					0	0	1	0	0
WBP11	51729	broad.mit.edu	37	12	14947652	14947652	+	Silent	SNP	A	A	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:14947652A>T	ENST00000261167.2	-	7	773	c.540T>A	c.(538-540)gtT>gtA	p.V180V	WBP11_ENST00000537574.1_Silent_p.V180V	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	180	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						GAAGGATAGAAACTGCCCGAG	0.448000													29	65					0	0	1	0	0
OR5M10	390167	broad.mit.edu	37	11	56345162	56345162	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:56345162G>A	ENST00000526812.2	-	1	101	c.36C>T	c.(34-36)ttC>ttT	p.F12F		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						CTAAGAGAATGAATTCTGTCA	0.453000													21	55					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64532455	64532455	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:64532455C>T	ENST00000498707.1	-	32	5385	c.5043G>A	c.(5041-5043)tgG>tgA	p.W1681*	ADAMTS9_ENST00000295903.4_Nonsense_Mutation_p.W1653*	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1681	TSP type-1 15.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TGCCAACTCTCCAGGTGGCCG	0.547000													34	60					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70954541	70954541	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:70954541G>A	ENST00000334414.6	-	17	4386	c.4342C>T	c.(4342-4344)Caa>Taa	p.Q1448*	PTPRB_ENST00000261266.5_Nonsense_Mutation_p.Q1230*|PTPRB_ENST00000550358.1_Nonsense_Mutation_p.Q1360*|PTPRB_ENST00000538708.1_Nonsense_Mutation_p.Q1140*|PTPRB_ENST00000451516.2_Nonsense_Mutation_p.Q1140*|PTPRB_ENST00000551525.1_Nonsense_Mutation_p.Q1447*|PTPRB_ENST00000550857.1_Nonsense_Mutation_p.Q1140*	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1230	Fibronectin type-III 17.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ACAAGGCCTTGAAACCGCCAC	0.493000													9	17					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234894470	234894470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:234894470C>T	ENST00000324695.4	+	21	2940	c.2900C>T	c.(2899-2901)aCc>aTc	p.T967I	TRPM8_ENST00000433712.2_Missense_Mutation_p.T545I	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	967						integral to membrane		p.T967N(1)		breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	ATGTTATCCACCAACATCCTG	0.567000													13	21					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33703378	33703378	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr13:33703378T>A	ENST00000336934.5	-	5	1552	c.1436A>T	c.(1435-1437)aAa>aTa	p.K479I	STARD13_ENST00000255486.4_Missense_Mutation_p.K471I|STARD13_ENST00000399365.3_Missense_Mutation_p.K361I	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	479					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		AAGGTCATCTTTCTCCAAGTC	0.507000													30	47					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480892	140480892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:140480892C>T	ENST00000231130.2	+	1	659	c.659C>T	c.(658-660)cCc>cTc	p.P220L	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		220	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCGGCTCTCCCCCTCGGTCT	0.552000													16	32					0	0	1	0	0
OGFOD3	79701	broad.mit.edu	37	17	80352403	80352403	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:80352403C>T	ENST00000329197.5	-	9	930	c.840G>A	c.(838-840)cgG>cgA	p.R280R	OGFOD3_ENST00000313056.5_Intron					2-oxoglutarate and iron-dependent oxygenase domain containing 3																		AAGACATCATCCGGAAACAAA	0.582000													31	74					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69535692	69535692	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:69535692C>T	ENST00000338206.5	-	1	654	c.645G>A	c.(643-645)atG>atA	p.M215I		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	215					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										GCATATGTATCATATTTTTTA	0.343000													37	95					0	0	1	0	0
IFNA21	3452	broad.mit.edu	37	9	21166195	21166195	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:21166195G>A	ENST00000380225.1	-	1	464	c.417C>T	c.(415-417)tcC>tcT	p.S139S		NM_002175.2	NP_002166.2	P01568	IFN21_HUMAN	interferon, alpha 21	139					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)	14				GBM - Glioblastoma multiforme(5;1.93e-187)|Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CAGCCAGGATGGAGTCCACAT	0.463000													93	100					0	0	1	0	0
A4GNT	51146	broad.mit.edu	37	3	137843393	137843393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:137843393C>T	ENST00000236709.3	-	3	937	c.736G>A	c.(736-738)Gac>Aac	p.D246N		NM_016161.2	NP_057245.1	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	246					protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)	16						CACCTGAGGTCGCTCACCTCC	0.483000													22	52					0	0	1	0	0
DCX	1641	broad.mit.edu	37	X	110654119	110654119	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:110654119G>A	ENST00000338081.3	-	1	255	c.84C>T	c.(82-84)tcC>tcT	p.S28S	DCX_ENST00000371993.2_Intron|DCX_ENST00000356915.2_Intron|DCX_ENST00000356220.3_Intron|DCX_ENST00000496551.1_Intron|DCX_ENST00000488120.1_Intron	NM_000555.3	NP_000546.2	O43602	DCX_HUMAN	doublecortin	28					axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|skin(6)|upper_aerodigestive_tract(1)	41						GAGAACAGAAGGAGCTACCCA	0.418000													75	151					0	0	1	0	0
LEKR1	389170	broad.mit.edu	37	3	156729226	156729226	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:156729226G>A	ENST00000470811.1	+	11	1557	c.222G>A	c.(220-222)caG>caA	p.Q74Q	LEKR1_ENST00000356539.4_Silent_p.Q378Q			D3DNK7	D3DNK7_HUMAN	leucine, glutamate and lysine rich 1	83										breast(1)|large_intestine(5)|lung(3)|ovary(1)|skin(1)	11			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TTTCACATCAGAAAAGCATCG	0.443000													12	25					0	0	1	0	0
OTOP1	133060	broad.mit.edu	37	4	4199274	4199274	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:4199274G>A	ENST00000296358.4	-	5	1311	c.1287C>T	c.(1285-1287)tcC>tcT	p.S429S		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	429					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCGCCAGGATGGAGTAGGGCA	0.562000													27	81					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111398043	111398043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:111398043G>A	ENST00000265162.5	+	1	815	c.473G>A	c.(472-474)cGg>cAg	p.R158Q		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	158					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GTGCAAGTCCGGAGGTGTTTC	0.627000													70	165					0	0	1	0	0
RNASEH2B	79621	broad.mit.edu	37	13	51501579	51501579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr13:51501579G>A	ENST00000336617.3	+	2	500	c.101G>A	c.(100-102)gGg>gAg	p.G34E	RNASEH2B_ENST00000422660.1_Missense_Mutation_p.G34E	NM_024570.3	NP_078846.2	Q5TBB1	RNH2B_HUMAN	ribonuclease H2, subunit B	34					RNA catabolic process	nucleus|ribonuclease H2 complex				endometrium(2)|liver(1)|lung(1)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)		ATGAAAAATGGGCTAATGTTT	0.308000													13	34					0	0	1	0	0
ROPN1L	83853	broad.mit.edu	37	5	10461434	10461434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:10461434G>A	ENST00000503804.1	+	5	1077	c.556G>A	c.(556-558)Gag>Aag	p.E186K	ROPN1L_ENST00000274134.4_Missense_Mutation_p.E186K|ROPN1L_ENST00000510520.1_3'UTR			Q96C74	ROP1L_HUMAN	rhophilin associated tail protein 1-like	186					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)	14						GTCTCCCTTGGAGACGGAATC	0.502000													46	84					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3565983	3565983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:3565983C>T	ENST00000520002.1	-	7	1517	c.962G>A	c.(961-963)gGa>gAa	p.G321E	CSMD1_ENST00000539096.1_Missense_Mutation_p.G321E|CSMD1_ENST00000537824.1_Missense_Mutation_p.G321E|CSMD1_ENST00000542608.1_Missense_Mutation_p.G321E|CSMD1_ENST00000602723.1_Missense_Mutation_p.G321E|CSMD1_ENST00000400186.3_Missense_Mutation_p.G321E|CSMD1_ENST00000602557.1_Missense_Mutation_p.G321E			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	321						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CATCTTGACTCCTCTTGACTT	0.438000													18	36					0	0	1	0	0
KLHL22	84861	broad.mit.edu	37	22	20825681	20825681	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:20825681G>A	ENST00000328879.4	-	3	505	c.349C>T	c.(349-351)Ctg>Ttg	p.L117L	KLHL22_ENST00000440659.2_Intron	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	117	BTB.				cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			ACATTGCTCAGGCTGAGCTCC	0.537000													13	43					0	0	1	0	0
RPSAP58	388524	broad.mit.edu	37	19	24010424	24010424	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:24010424T>G	ENST00000496398.1	+	4	884	c.461T>G	c.(460-462)cTg>cGg	p.L154R	RPSAP58_ENST00000354585.4_Missense_Mutation_p.L154R|RP11-255H23.2_ENST00000471224.1_RNA|RP11-255H23.4_ENST00000599944.1_lincRNA																endometrium(1)|kidney(5)|lung(2)|prostate(1)|urinary_tract(1)	10						GATTCTCCTCTGCGCTATGTG	0.542000													15	18					0	0	1	0	0
DMRTC2	63946	broad.mit.edu	37	19	42351641	42351641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:42351641G>A	ENST00000269945.3	+	2	196	c.145G>A	c.(145-147)Ggt>Agt	p.G49S	DMRTC2_ENST00000602098.1_3'UTR|DMRTC2_ENST00000596827.1_Missense_Mutation_p.G49S	NM_001040283.1	NP_001035373.1	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	49					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	10						CCGCAACCATGGTGTCACCGC	0.622000													40	47					0	0	1	0	0
CPEB4	80315	broad.mit.edu	37	5	173376543	173376543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:173376543C>T	ENST00000265085.5	+	6	2943	c.1489C>T	c.(1489-1491)Cct>Tct	p.P497S	CPEB4_ENST00000520867.1_Missense_Mutation_p.P472S|CPEB4_ENST00000522336.1_Missense_Mutation_p.P107S|CPEB4_ENST00000519467.1_3'UTR|CPEB4_ENST00000334035.5_Missense_Mutation_p.P480S|CPEB4_ENST00000517880.1_Missense_Mutation_p.P90S|CPEB4_ENST00000519835.1_Missense_Mutation_p.P472S	NM_030627.2	NP_085130.2	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding protein 4	497	RRM 1.						nucleotide binding|RNA binding			NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	20	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			TCGCTTTGGCCCTCTGATTGT	0.308000													10	26					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55321932	55321932	+	Silent	SNP	T	T	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:55321932T>C	ENST00000314644.2	+	1	150	c.150T>C	c.(148-150)ttT>ttC	p.F50F		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						CTTTCATCTTTTCCTTGGGAA	0.363000										HNSCC(20;0.049)			38	92					0	0	1	0	0
SCLT1	132320	broad.mit.edu	37	4	129924930	129924930	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:129924930C>T	ENST00000281142.5	-	6	895	c.392G>A	c.(391-393)aGa>aAa	p.R131K	SCLT1_ENST00000439369.2_Intron|SCLT1_ENST00000434680.1_Missense_Mutation_p.R131K|SCLT1_ENST00000503215.1_Missense_Mutation_p.R108K	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	131						centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						TTGAAGGTTTCTGACTGTTTC	0.338000													11	47					0	0	1	0	0
PCSK7	9159	broad.mit.edu	37	11	117100314	117100314	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:117100314G>A	ENST00000320934.3	-	3	877	c.247C>T	c.(247-249)Ctg>Ttg	p.L83L		NM_004716.2	NP_004707.2	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	83					peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity			NS(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	16	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		GCATTCACCAGCCCTGCTGCC	0.667000			T	IGH@	MLCLS								23	50					0	0	1	0	0
CCDC36	339834	broad.mit.edu	37	3	49293771	49293771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:49293771C>T	ENST00000438782.1	+	8	1077	c.841C>T	c.(841-843)Ctc>Ttc	p.L281F	CCDC36_ENST00000452691.2_Missense_Mutation_p.L281F|CCDC36_ENST00000296449.5_Missense_Mutation_p.L281F			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	281										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		GGCCCAGAGCCTCAATCTCAC	0.542000													12	48					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66481770	66481770	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:66481770C>T	ENST00000256447.4	-	2	323	c.166G>A	c.(166-168)Gaa>Aaa	p.E56K		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	56					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		TCCAAAAATTCTGTTGTGTTT	0.333000													30	31					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44815549	44815549	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr20:44815549G>A	ENST00000372262.3	-	8	1861	c.1461C>T	c.(1459-1461)atC>atT	p.I487I	CDH22_ENST00000537909.1_Silent_p.I487I	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	487	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				CCAGGATTCGGATCCTTAGGG	0.567000													70	138					0	0	1	0	0
NTNG2	84628	broad.mit.edu	37	9	135073874	135073874	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:135073874G>A	ENST00000393229.3	+	3	1511	c.735G>A	c.(733-735)gaG>gaA	p.E245E	NTNG2_ENST00000393228.4_Silent_p.E245E|NTNG2_ENST00000360670.3_Silent_p.E245E|NTNG2_ENST00000372179.3_Silent_p.E245E	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	245	Laminin N-terminal.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		GCCTCAAGGAGTTCTTCACCC	0.647000													7	96					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21731270	21731270	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:21731270T>C	ENST00000584755.1	+	2	969	c.572T>C	c.(571-573)aTc>aCc	p.I191T	UBBP4_ENST00000578713.1_Intron|UBBP4_ENST00000583708.1_3'UTR														p.I191T(3)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						ATCCCCCCGATCAGCAGAGGC	0.547000													4	88					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23775375	23775375	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:23775375G>A	ENST00000354639.3	+	7	1097	c.633G>A	c.(631-633)agG>agA	p.R211R	STK31_ENST00000355870.3_Silent_p.R234R|STK31_ENST00000433467.2_Silent_p.R234R|STK31_ENST00000428484.1_Silent_p.R211R|STK31_ENST00000405627.3_3'UTR	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	234							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TTGTTCTCAGGAACCTCAAAA	0.448000													30	60					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193132383	193132383	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:193132383G>A	ENST00000342695.4	-	26	3321	c.2999C>T	c.(2998-3000)tCc>tTc	p.S1000F	ATP13A4_ENST00000392443.3_Missense_Mutation_p.S981F|ATP13A4_ENST00000400270.2_Missense_Mutation_p.S16F	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	1000					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TATCTCCACGGAATACCAAGG	0.463000													12	29					0	0	1	0	0
GPHB5	122876	broad.mit.edu	37	14	63779790	63779790	+	RNA	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:63779790C>T	ENST00000539258.1	-	0	300							Q86YW7	GPHB5_HUMAN	glycoprotein hormone beta 5							extracellular region	hormone activity			breast(1)|endometrium(1)|lung(4)|urinary_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(108;0.00372)|all cancers(60;0.0226)|BRCA - Breast invasive adenocarcinoma(234;0.0978)		GGTACAGACTCGATGATGGGC	0.483000													6	7					0	0	1	0	0
GLYATL2	219970	broad.mit.edu	37	11	58601949	58601949	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:58601949G>A	ENST00000287275.1	-	6	1228	c.838C>T	c.(838-840)Cct>Tct	p.P280S	GLYATL2_ENST00000532258.1_Missense_Mutation_p.P280S	NM_145016.3	NP_659453.3	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	280						mitochondrion	glycine N-acyltransferase activity			breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	23		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	CAGCCACAAGGACAAATCTTA	0.353000													10	51					0	0	1	0	0
KANK2	25959	broad.mit.edu	37	19	11280857	11280857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:11280857G>A	ENST00000432929.2	-	11	2663	c.2303C>T	c.(2302-2304)gCc>gTc	p.A768V	KANK2_ENST00000587317.1_5'UTR|KANK2_ENST00000589359.1_Missense_Mutation_p.A768V|KANK2_ENST00000589894.1_Missense_Mutation_p.A760V|KANK2_ENST00000586659.1_Missense_Mutation_p.A760V|KANK2_ENST00000355150.5_Missense_Mutation_p.A760V	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	760										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						TGCCTCACAGGCCAGCAGGGC	0.637000													28	45					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201460035	201460035	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:201460035C>T	ENST00000374700.2	+	3	385	c.144C>T	c.(142-144)ggC>ggT	p.G48G		NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	48	2Fe-2S ferredoxin-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GAGGAGGAGGCTGTGGTGCTT	0.408000													4	17					0	0	1	0	0
SLC9A9	285195	broad.mit.edu	37	3	143185968	143185968	+	Missense_Mutation	SNP	C	C	T	rs146502252		TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:143185968C>T	ENST00000316549.6	-	12	1588	c.1380G>A	c.(1378-1380)atG>atA	p.M460I		NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	460					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						TGGTAAACATCATTTGTTTGG	0.468000													19	42					0	0	1	0	0
DCAF11	80344	broad.mit.edu	37	14	24590594	24590594	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:24590594C>T	ENST00000446197.3	+	13	1994	c.1267C>T	c.(1267-1269)Cca>Tca	p.P423S	DCAF11_ENST00000559115.1_Missense_Mutation_p.P423S|RP11-468E2.6_ENST00000558325.1_Missense_Mutation_p.P12L|DCAF11_ENST00000396941.4_Missense_Mutation_p.P397S|DCAF11_ENST00000396936.1_Missense_Mutation_p.P323S	NM_025230.4	NP_079506.3	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11	423						CUL4 RING ubiquitin ligase complex	protein binding										GCTGAAGCTCCCAGGGGACAG	0.572000													26	91					0	0	1	0	0
DLG4	1742	broad.mit.edu	37	17	7097293	7097293	+	Nonsense_Mutation	SNP	A	A	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:7097293A>C	ENST00000399510.2	-	15	2486	c.1634T>G	c.(1633-1635)tTa>tGa	p.L545*	DLG4_ENST00000302955.6_Nonsense_Mutation_p.L499*|DLG4_ENST00000399506.2_Nonsense_Mutation_p.L502*	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	502	Guanylate kinase-like.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						CTTGGCCTTTAACCTTGACCA	0.582000													8	22					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112751911	112751911	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:112751911G>A	ENST00000295408.4	+	9	1637	c.1380G>A	c.(1378-1380)agG>agA	p.R460R	MERTK_ENST00000409780.1_Silent_p.R284R|MERTK_ENST00000421804.2_Silent_p.R460R			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	460	Fibronectin type-III 2.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						GCACAGTGAGGATTGCAGCCG	0.527000													53	134					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25976476	25976476	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:25976476G>A	ENST00000435504.4	-	11	1362	c.1069C>T	c.(1069-1071)Cga>Tga	p.R357*	ASXL2_ENST00000336112.4_Nonsense_Mutation_p.R329*|ASXL2_ENST00000404843.1_Nonsense_Mutation_p.R97*|ASXL2_ENST00000272341.4_Nonsense_Mutation_p.R97*			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	357					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding	p.R97*(1)|p.R357*(1)		NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATCTCTTGTCGAATTCTCACC	0.358000													45	53					0	0	1	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4451500	4451500	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:4451500A>C	ENST00000254718.4	-	12	1968	c.1662T>G	c.(1660-1662)aaT>aaG	p.N554K	MYBBP1A_ENST00000381556.2_Missense_Mutation_p.N554K			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a	554	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)	24						TGTGGCTGTGATTCAACAGGA	0.652000													23	59					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27803714	27803714	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:27803714G>A	ENST00000408964.2	+	1	4326	c.4275G>A	c.(4273-4275)gaG>gaA	p.E1425E		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1425										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					TTAAGCAGGAGGACATATTGT	0.502000													46	45					0	0	1	0	0
TST	7263	broad.mit.edu	37	22	37407346	37407346	+	Missense_Mutation	SNP	G	G	A	rs61742280	byFrequency	TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:37407346G>A	ENST00000403892.3	-	2	1350	c.616C>T	c.(616-618)Cgt>Tgt	p.R206C	TST_ENST00000249042.3_Missense_Mutation_p.R206C	NM_001270483.1	NP_001257412.1	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase (rhodanese)	206	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	7						ACGGCACCACGGATATGGCCC	0.572000													12	43					0	0	1	0	0
RTN2	6253	broad.mit.edu	37	19	45992717	45992717	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr19:45992717G>A	ENST00000590526.1	-	6	1432	c.306C>T	c.(304-306)atC>atT	p.I102I	PPM1N_ENST00000401705.1_Intron|RTN2_ENST00000245923.4_Silent_p.I376I|RTN2_ENST00000344680.4_Silent_p.I303I|RTN2_ENST00000430715.2_Silent_p.I36I			O75298	RTN2_HUMAN	reticulon 2	376						integral to endoplasmic reticulum membrane	signal transducer activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(4)|skin(1)|urinary_tract(1)	20		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		CCACGGACACGATGCTAAAGT	0.622000													7	5					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28260241	28260241	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr10:28260241C>T	ENST00000305242.5	-	8	1030	c.936_splice	c.e8-1	p.G313_splice	ARMC4_ENST00000480504.1_5'UTR|ARMC4_ENST00000545014.1_Intron|ARMC4_ENST00000239715.3_Splice_Site_p.G170_splice|ARMC4_ENST00000537576.1_Splice_Site_p.G5_splice	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	313							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						GAAGCTAATTCCCTTTATTTA	0.393000													7	19					0	0	1	0	0
ERCC3	2071	broad.mit.edu	37	2	128046242	128046242	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:128046242G>A	ENST00000493187.2	-	7	1292	c.829C>T	c.(829-831)Ccc>Tcc	p.P277S	ERCC3_ENST00000285398.2_Missense_Mutation_p.P341S			P19447	ERCC3_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 3	341					cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	31	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TTACCGCAGGGAAGAACAATG	0.527000			"""Mis, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				184	464					0	0	1	0	0
NTRK2	4915	broad.mit.edu	37	9	87549127	87549127	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr9:87549127G>A	ENST00000376214.1	+	17	2622	c.1684G>A	c.(1684-1686)Gaa>Aaa	p.E562K	NTRK2_ENST00000277120.3_Missense_Mutation_p.E562K|NTRK2_ENST00000376213.1_Missense_Mutation_p.E546K|NTRK2_ENST00000323115.4_Missense_Mutation_p.E546K	NM_006180.3	NP_006171.2	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	546	Protein kinase.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						GGAGCTAGGCGAAGGAGCCTT	0.438000										TSP Lung(25;0.17)			15	22					0	0	1	0	0
OR10A3	26496	broad.mit.edu	37	11	7960717	7960717	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:7960717C>T	ENST00000360759.3	-	1	424	c.351G>A	c.(349-351)gcG>gcA	p.A117A		NM_001003745.1	NP_001003745.1	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A, member 3	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)	21				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CATAAGCCATCGCTCCCAGGA	0.398000													31	87					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141032134	141032134	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:141032134G>A	ENST00000389484.3	-	85	13972	c.13001C>T	c.(13000-13002)tCa>tTa	p.S4334L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4334	EGF-like 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATGGTACATGATTCAGAATT	0.403000										TSP Lung(27;0.18)			11	35					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25678074	25678074	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr4:25678074C>T	ENST00000382051.3	+	13	1826	c.1776C>T	c.(1774-1776)ttC>ttT	p.F592F	SLC34A2_ENST00000504570.1_Silent_p.F591F|SLC34A2_ENST00000503434.1_Silent_p.F591F	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	592				Missing (in Ref. 6; BAC11354).	cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				ACTGGAACTTCCTGCCGCTGT	0.622000			T	ROS1	NSCLC								55	110					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192424	132192424	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:132192424C>T	ENST00000359827.3	-	2	1991	c.1029G>A	c.(1027-1029)caG>caA	p.Q343Q	PLXNA4_ENST00000423507.2_Silent_p.Q343Q|PLXNA4_ENST00000378539.5_Silent_p.Q343Q|PLXNA4_ENST00000321063.4_Silent_p.Q343Q			Q9HCM2	PLXA4_HUMAN	plexin A4	343	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TTTTCCGCTTCTGGCCCTTGG	0.557000													27	51					0	0	1	0	0
CCDC36	339834	broad.mit.edu	37	3	49293770	49293770	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr3:49293770C>T	ENST00000438782.1	+	8	1076	c.840C>T	c.(838-840)agC>agT	p.S280S	CCDC36_ENST00000452691.2_Silent_p.S280S|CCDC36_ENST00000296449.5_Silent_p.S280S			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	280										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		TGGCCCAGAGCCTCAATCTCA	0.542000													12	45					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20845562	20845562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:20845562C>T	ENST00000262715.5	-	41	6005	c.5965G>A	c.(5965-5967)Gat>Aat	p.D1989N	TEP1_ENST00000545983.1_Missense_Mutation_p.D327N|TEP1_ENST00000556935.1_Missense_Mutation_p.D1881N	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1989					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AAGGACCCATCTTCTGCACCA	0.597000													22	42					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66437954	66437954	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:66437954G>A	ENST00000404260.3	+	20	2823	c.2515G>A	c.(2515-2517)Gaa>Aaa	p.E839K	MAST4_ENST00000403666.1_Missense_Mutation_p.E647K|MAST4_ENST00000405643.1_Missense_Mutation_p.E657K|MAST4_ENST00000261569.7_Missense_Mutation_p.E642K|MAST4_ENST00000403625.2_Missense_Mutation_p.E836K			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	839	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TGGTGCATATGAAGTCAAACA	0.428000													33	88					0	0	1	0	0
DHODH	1723	broad.mit.edu	37	16	72055148	72055148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr16:72055148C>T	ENST00000572887.1	+	5	820	c.643C>T	c.(643-645)Ccc>Tcc	p.P215S	DHODH_ENST00000573922.1_Intron|DHODH_ENST00000219240.4_Missense_Mutation_p.P215S			Q02127	PYRD_HUMAN	dihydroorotate dehydrogenase (quinone)	215	Substrate binding.				'de novo' pyrimidine base biosynthetic process|pyrimidine nucleoside biosynthetic process|UMP biosynthetic process	integral to membrane|mitochondrial inner membrane	dihydroorotate oxidase activity			breast(1)|endometrium(2)|large_intestine(4)|ovary(1)|skin(1)|stomach(1)	10		Ovarian(137;0.125)			Atovaquone(DB01117)|Leflunomide(DB01097)	TGTGTCCAGCCCCAACACTGC	0.677000													8	14					0	0	1	0	0
KCND3	3752	broad.mit.edu	37	1	112525211	112525211	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr1:112525211C>T	ENST00000369697.1	-	1	207	c.138G>A	c.(136-138)gtG>gtA	p.V46V	KCND3_ENST00000315987.2_Silent_p.V46V|KCND3_ENST00000302127.4_Silent_p.V46V			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	46						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		TCCGCCCACTCACGTTGAGGA	0.652000													22	14					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119345489	119345489	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:119345489C>T	ENST00000338891.7	-	2	1092	c.649G>A	c.(649-651)Gaa>Aaa	p.E217K	RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000368475.4_Missense_Mutation_p.E97K|FAM184A_ENST00000522284.1_Missense_Mutation_p.E97K|FAM184A_ENST00000521531.1_Missense_Mutation_p.E217K|FAM184A_ENST00000352896.5_Missense_Mutation_p.E97K	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	217										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						TCTGCCTTTTCCTGGCCTTTA	0.453000													10	41					0	0	1	0	0
DCX	1641	broad.mit.edu	37	X	110654120	110654120	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:110654120G>A	ENST00000338081.3	-	1	254	c.83C>T	c.(82-84)tCc>tTc	p.S28F	DCX_ENST00000371993.2_Intron|DCX_ENST00000356915.2_Intron|DCX_ENST00000356220.3_Intron|DCX_ENST00000496551.1_Intron|DCX_ENST00000488120.1_Intron	NM_000555.3	NP_000546.2	O43602	DCX_HUMAN	doublecortin	28					axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|skin(6)|upper_aerodigestive_tract(1)	41						AGAACAGAAGGAGCTACCCAA	0.418000													76	149					0	0	1	0	0
TPCN1	53373	broad.mit.edu	37	12	113717996	113717996	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:113717996C>T	ENST00000550785.1	+	16	1723	c.1554C>T	c.(1552-1554)ttC>ttT	p.F518F	TPCN1_ENST00000335509.6_Silent_p.F446F|TPCN1_ENST00000541517.1_Silent_p.F518F|TPCN1_ENST00000392569.4_Silent_p.F378F	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	446						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity	p.F446F(1)		cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						TCCAGTATTTCATGTGTAAGT	0.423000													9	19					0	0	1	0	0
TAS2R9	50835	broad.mit.edu	37	12	10961759	10961759	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:10961759T>C	ENST00000240691.2	-	1	1008	c.916A>G	c.(916-918)Aga>Gga	p.R306G		NM_023917.2	NP_076406.1	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	306					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GGCTTTCTTCTTCTAAGGAAA	0.373000													21	47					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180338611	180338611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:180338611G>A	ENST00000231229.4	+	3	904	c.670G>A	c.(670-672)Gga>Aga	p.G224R	BTNL8_ENST00000533815.2_Missense_Mutation_p.G40R|BTNL8_ENST00000511704.1_Missense_Mutation_p.G108R|BTNL8_ENST00000508408.1_Missense_Mutation_p.G224R|BTNL8_ENST00000505126.1_Missense_Mutation_p.G17R|BTNL8_ENST00000400707.3_Missense_Mutation_p.G99R|BTNL8_ENST00000340184.4_Missense_Mutation_p.G224R	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	224						integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGTACAGATAGGAGGTGAGTA	0.547000													26	44					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228155544	228155544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:228155544G>A	ENST00000396578.3	+	37	3314	c.3152G>A	c.(3151-3153)gGa>gAa	p.G1051E	AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000396588.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	1051	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGTCTCCAGGGAGATAAGGGA	0.493000													10	19					0	0	1	0	0
SLC41A2	84102	broad.mit.edu	37	12	105238262	105238262	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr12:105238262G>A	ENST00000258538.3	-	9	1651	c.1524C>T	c.(1522-1524)ggC>ggT	p.G508G		NM_032148.3	NP_115524.3	Q96JW4	S41A2_HUMAN	solute carrier family 41 (magnesium transporter), member 2	508						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	22						GTAACACAGCGCCAAATAAAT	0.313000													12	62					0	0	1	0	0
ZNF630	57232	broad.mit.edu	37	X	47918590	47918590	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chrX:47918590C>T	ENST00000276054.4	-	5	1803	c.869G>A	c.(868-870)cGg>cAg	p.R290Q	ZNF630_ENST00000442455.3_Missense_Mutation_p.R400Q|ZNF630-AS1_ENST00000436124.1_RNA|ZNF630_ENST00000409324.3_Missense_Mutation_p.R414Q			Q2M218	ZN630_HUMAN	zinc finger protein 630	414					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)|ovary(1)	19						CTGTGTTTTCCGAGGGAAGGT	0.443000													15	18					0	0	1	0	0
FNDC8	54752	broad.mit.edu	37	17	33454248	33454248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:33454248G>A	ENST00000158009.5	+	2	512	c.397G>A	c.(397-399)Gag>Aag	p.E133K		NM_017559.2	NP_060029.1	Q8TC99	FNDC8_HUMAN	fibronectin type III domain containing 8	133										breast(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)	11		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.022)		TGCAGAAAATGAGGACCTGGC	0.582000													59	141					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118715984	118715984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:118715984G>A	ENST00000376300.2	-	12	1099	c.962C>T	c.(961-963)tCc>tTc	p.S321F	CCDC93_ENST00000319432.5_Missense_Mutation_p.S320F|CCDC93_ENST00000460781.1_5'UTR	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	321										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						TTTGTTCAAGGAAATGACTTT	0.408000													10	44					0	0	1	0	0
CLASP1	23332	broad.mit.edu	37	2	122227480	122227480	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:122227480A>T	ENST00000263710.4	-	9	1158	c.769T>A	c.(769-771)Tct>Act	p.S257T	CLASP1_ENST00000541859.1_Missense_Mutation_p.S26T|CLASP1_ENST00000541377.1_Missense_Mutation_p.S257T|CLASP1_ENST00000545861.1_Missense_Mutation_p.S25T|CLASP1_ENST00000397587.3_Missense_Mutation_p.S257T|CLASP1_ENST00000430234.1_5'UTR|CLASP1_ENST00000455322.2_Missense_Mutation_p.S257T|CLASP1_ENST00000409078.3_Missense_Mutation_p.S257T	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	257					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					GATGATGTAGAACTAGCAGAG	0.438000													29	58					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33874775	33874775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr20:33874775C>T	ENST00000374408.3	-	4	1903	c.1807G>A	c.(1807-1809)Gcc>Acc	p.A603T		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	603										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GAACCCTGGGCCTTGGGGTAC	0.632000													26	58					0	0	1	0	0
GINS4	84296	broad.mit.edu	37	8	41399552	41399552	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr8:41399552C>T	ENST00000276533.3	+	8	828	c.618C>T	c.(616-618)atC>atT	p.I206I	GINS4_ENST00000523277.2_3'UTR|RP11-360L9.4_ENST00000523081.1_RNA|GINS4_ENST00000518671.1_Silent_p.I206I|RP11-360L9.7_ENST00000524133.1_RNA	NM_032336.2	NP_115712.1	Q9BRT9	SLD5_HUMAN	GINS complex subunit 4 (Sld5 homolog)	206	Important for GINS complex assembly.				DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm				breast(1)|lung(2)|skin(1)	4	Ovarian(28;0.014)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.00732)|Lung NSC(58;0.0207)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00329)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			AGCACTTGATCCGATACAAAA	0.512000													27	74					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1272041	1272041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:1272041G>A	ENST00000447027.1	+	31	13998	c.13940G>A	c.(13939-13941)gGg>gAg	p.G4647E	MUC5B_ENST00000529681.1_Missense_Mutation_p.G4644E			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4644	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		tccatcccggggaccacccac	0.622000													12	43					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10931711	10931711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:10931711G>A	ENST00000283141.6	+	20	1968	c.1672G>A	c.(1672-1674)Gag>Aag	p.E558K		NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	558						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			CAGTGGCCATGAGAAAGACCA	0.363000													21	58					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141039041	141039041	+	Silent	SNP	G	G	A	rs146842496		TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:141039041G>A	ENST00000239440.4	-	23	3335	c.3270C>T	c.(3268-3270)atC>atT	p.I1090I	ARAP3_ENST00000513878.1_Silent_p.I752I|ARAP3_ENST00000512390.1_5'UTR|ARAP3_ENST00000508305.1_Silent_p.I921I	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	1090					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						GGTCAGAATCGATCTGTGAAA	0.532000													14	24					0	0	1	0	0
DPCR1	135656	broad.mit.edu	37	6	30920134	30920134	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:30920134C>T	ENST00000462446.1	+	2	3921	c.3893C>T	c.(3892-3894)cCa>cTa	p.P1298L	DPCR1_ENST00000304311.2_Missense_Mutation_p.P140L|HCG21_ENST00000419481.1_RNA			Q3MIW9	DPCR1_HUMAN	diffuse panbronchiolitis critical region 1	422						integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)	10						GAGAGCCATCCATACCTCAAT	0.473000													22	59					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73718532	73718532	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:73718532C>T	ENST00000427855.1	+	9	933	c.831C>T	c.(829-831)ccC>ccT	p.P277P	PAPLN_ENST00000555445.1_Silent_p.P277P|PAPLN_ENST00000381166.3_Silent_p.P277P|PAPLN_ENST00000554301.1_Silent_p.P277P|PAPLN_ENST00000340738.5_Silent_p.P250P			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	277						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CCTCGGAGCCCCTGGTCATCG	0.682000													10	27					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135692374	135692374	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr5:135692374G>A	ENST00000513104.1	-	2	984	c.702C>T	c.(700-702)tcC>tcT	p.S234S	TRPC7_ENST00000426057.2_Silent_p.S234S|TRPC7_ENST00000355180.3_Silent_p.S234S	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	234					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGTCTTCGCTGGACAGGGACA	0.552000													10	30					0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31285540	31285540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:31285540C>T	ENST00000332585.6	+	7	1644	c.1540C>T	c.(1540-1542)Ccc>Tcc	p.P514S	OSBP2_ENST00000446658.2_Missense_Mutation_p.P513S|OSBP2_ENST00000403222.3_Missense_Mutation_p.P348S|OSBP2_ENST00000382310.3_Intron|OSBP2_ENST00000437268.2_Missense_Mutation_p.P256S|OSBP2_ENST00000407373.1_Missense_Mutation_p.P341S|OSBP2_ENST00000401475.1_Missense_Mutation_p.P147S|OSBP2_ENST00000535268.1_Missense_Mutation_p.P58S	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	514					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						AGTCCGCATTCCCAACAAGCC	0.597000													54	158					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76503719	76503719	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr17:76503719G>A	ENST00000389840.5	-	28	4517	c.4393C>T	c.(4393-4395)Ctg>Ttg	p.L1465L	DNAH17_ENST00000585328.1_Silent_p.L1466L					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ACCTCCTTCAGGAAGTGGGCC	0.587000													16	27					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46859772	46859772	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr22:46859772G>A	ENST00000262738.3	-	2	4014	c.4015C>T	c.(4015-4017)Cgg>Tgg	p.R1339W	CELSR1_ENST00000395964.1_Missense_Mutation_p.R1339W	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1339	EGF-like 1; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TGGATGGGCCGGAAGAGCACG	0.662000													8	17					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43610140	43610140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr10:43610140G>A	ENST00000355710.3	+	11	2324	c.2092G>A	c.(2092-2094)Gac>Aac	p.D698N	RET_ENST00000340058.5_Missense_Mutation_p.D698N	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	698					homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	GCCCTCGCTGGACTCCATGGA	0.667000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				6	14					0	0	1	0	0
C6orf165	154313	broad.mit.edu	37	6	88173915	88173915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr6:88173915G>A	ENST00000507897.1	+	13	1899	c.1816G>A	c.(1816-1818)Gaa>Aaa	p.E606K	C6ORF165_ENST00000369562.4_Missense_Mutation_p.E606K|C6orf165_ENST00000506888.1_3'UTR			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	606										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AGGAAAGAGCGAAATCACCGA	0.458000													13	37					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6263042	6263042	+	Silent	SNP	G	G	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:6263042G>A	ENST00000533426.1	+	5	757	c.606G>A	c.(604-606)aaG>aaA	p.K202K	CNGA4_ENST00000379936.2_Intron			Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	560					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCAGGGACAAGGATGGGTGGG	0.527000													29	40					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													3	34					0	0	1	0	0
ALLC	55821	broad.mit.edu	37	2	3729240	3729240	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:3729240C>T	ENST00000252505.3	+	6	477	c.315C>T	c.(313-315)atC>atT	p.I105I		NM_018436.3	NP_060906.3	Q8N6M5	ALLC_HUMAN	allantoicase	124							allantoicase activity			breast(4)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	30	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		TACCAGAAATCCCAGAAAGAG	0.438000										HNSCC(21;0.051)			11	7					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117199595	117199595	+	Silent	SNP	C	C	T			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr7:117199595C>T	ENST00000003084.6	+	11	1602	c.1470C>T	c.(1468-1470)ttC>ttT	p.F490F	CFTR_ENST00000454343.1_Silent_p.F429F	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	490	ABC transporter 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GAATTTCATTCTGTTCTCAGT	0.368000									Cystic Fibrosis				21	74					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77950883	77950883	+	Missense_Mutation	SNP	G	G	A	rs138409143	byFrequency	TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:77950883G>A	ENST00000393684.3	-	4	537	c.146C>T	c.(145-147)cCt>cTt	p.P49L	ISM2_ENST00000342219.4_Missense_Mutation_p.P137L|ISM2_ENST00000493585.1_Missense_Mutation_p.P137L|ISM2_ENST00000412904.1_Intron|ISM2_ENST00000429906.1_Missense_Mutation_p.P56L			Q6H9L7	ISM2_HUMAN	isthmin 2	137						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						TTCCCTCAGAGGCCTAGGATC	0.602000													16	32					0	0	1	0	0
BRE	9577	broad.mit.edu	37	2	28521300	28521301	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr2:28521300_28521301insA	ENST00000344773.2	+	11	1168_1169	c.1030_1031insA	c.(1030-1032)aaafs	p.K344fs	BRE_ENST00000342045.2_Frame_Shift_Ins_p.K344fs|BRE_ENST00000379632.2_Frame_Shift_Ins_p.K344fs|BRE_ENST00000361704.2_Frame_Shift_Ins_p.K344fs|BRE_ENST00000379624.1_Frame_Shift_Ins_p.K344fs	NM_004899.4	NP_004890.2	Q9NXR7	BRE_HUMAN	brain and reproductive organ-expressed (TNFRSF1A modulator)	344	UEV-like 2.				apoptosis|chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of anti-apoptosis|positive regulation of DNA repair|response to ionizing radiation|signal transduction	BRCA1-A complex|BRISC complex|cytoplasm|nuclear ubiquitin ligase complex	peroxisome targeting sequence binding|polyubiquitin binding|tumor necrosis factor receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(2)	23	Acute lymphoblastic leukemia(172;0.155)					CTCCCAGGCCCAAAAAAATTAT	0.446													33	54	---	---	---	---					
STX5	6811	broad.mit.edu	37	11	62598585	62598585	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr11:62598585delG	ENST00000294179.3	-	2	284	c.131delC	c.(130-132)cafs	p.P44fs	STX5_ENST00000394690.1_Intron|STX5_ENST00000541317.1_Intron|STX5_ENST00000377897.4_Frame_Shift_Del_p.P44fs	NM_001244666.1|NM_003164.4	NP_001231595.1|NP_003155.2	Q13190	STX5_HUMAN	syntaxin 5	44					intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity	p.V45fs*38(1)		breast(2)|endometrium(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	18						GAGGGTCACTGGGGGGGGCAG	0.632													2	4	---	---	---	---					
RP11-536C10.4	0	broad.mit.edu	37	14	19340354	19340354	+	RNA	DEL	A	A	-			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr14:19340354delA	ENST00000552261.1	-	0	52																											TTCGGCATTTACGGACTTTTA	0.294													2	4	---	---	---	---					
RP11-1166P10.6	0	broad.mit.edu	37	16	32095553	32095553	+	RNA	DEL	G	G	-			TCGA-FW-A3TV-06A-11D-A23B-08	TCGA-FW-A3TV-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d09bfba-5cac-44ee-a834-e23601d91b86	dc2822ca-bd08-42ae-8a3f-5deb05fdefa9	g.chr16:32095553delG	ENST00000566806.1	-	0	499																											CTGGGGCCCCGAGGGAGATGT	0.642													3	5	---	---	---	---