Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TTN	7273	broad.mit.edu	37	2	179594488	179594488	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:179594488C>T	ENST00000589042.1	-	63	18716	c.18492G>A	c.(18490-18492)caG>caA	p.Q6164Q	TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Silent_p.Q5847Q|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Silent_p.Q4920Q|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5847	Ig-like 43.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACCAGAAATCTGGAAAGTGG	0.453000													100	69					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75979787	75979787	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:75979787G>A	ENST00000308508.5	-	3	3711	c.3619C>T	c.(3619-3621)Ccc>Tcc	p.P1207S		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	1207	Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GTGTCGCGGGGGCTGAGGCTG	0.642000													53	63					0	0	1	0	0
OR10H2	26538	broad.mit.edu	37	19	15839370	15839370	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:15839370G>A	ENST00000305899.3	+	1	537	c.517G>A	c.(517-519)Gag>Aag	p.E173K		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					TGGATCCCATGAGATCCAGCA	0.557000													47	58					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34022494	34022494	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr20:34022494C>T	ENST00000374372.1	-	4	1222	c.719G>A	c.(718-720)cGg>cAg	p.R240Q	GDF5OS_ENST00000374375.1_Missense_Mutation_p.R180C|GDF5_ENST00000374369.3_Missense_Mutation_p.R240Q			P43026	GDF5_HUMAN	growth differentiation factor 5	240					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			CCGCAAGATCCGCAGCTCGGC	0.667000													110	77					0	0	1	0	0
NF2	4771	broad.mit.edu	37	22	30035179	30035179	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr22:30035179C>T	ENST00000338641.4	+	3	782	c.341C>T	c.(340-342)aCa>aTa	p.T114I	NF2_ENST00000361452.4_Intron|NF2_ENST00000353887.4_Intron|NF2_ENST00000361166.4_Missense_Mutation_p.T114I|NF2_ENST00000413209.2_Missense_Mutation_p.T114I|NF2_ENST00000361676.4_Missense_Mutation_p.T72I|NF2_ENST00000347330.5_Intron|NF2_ENST00000403999.3_Missense_Mutation_p.T114I|NF2_ENST00000397789.3_Missense_Mutation_p.T114I|NF2_ENST00000334961.7_Intron|NF2_ENST00000403435.1_Missense_Mutation_p.T114I	NM_000268.3|NM_016418.5|NM_181832.2	NP_000259.1|NP_057502.2|NP_861970.1	P35240	MERL_HUMAN	neurofibromin 2 (merlin)	114	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.?(3)|p.H95fs*3(1)|p.?fs(1)		NS(1)|bone(2)|breast(5)|central_nervous_system(21)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(17)|large_intestine(9)|liver(1)|lung(9)|meninges(372)|ovary(2)|pituitary(1)|pleura(9)|prostate(1)|skin(7)|soft_tissue(303)|stomach(2)|thyroid(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	776						CAGGAGATCACACAACATTTA	0.463000			"""D, Mis, N, F, S, O"""		"""meningioma, acoustic neuroma, renal """	"""meningioma, acoustic neuroma"""			Neurofibromatosis, type 2				69	29					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23544915	23544915	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:23544915G>A	ENST00000300619.7	-	4	1071	c.866C>T	c.(865-867)aCt>aTt	p.T289I	ZNF91_ENST00000397082.2_Missense_Mutation_p.T257I|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	289						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTTCTCTCCAGTGTGTATCCT	0.383000													63	75					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940685	22940685	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:22940685G>A	ENST00000397104.3	-	5	1752	c.1753C>T	c.(1753-1755)Ccc>Tcc	p.P585S	ZNF99_ENST00000596209.1_Missense_Mutation_p.P676S					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CATTTGTAGGGTTTCTCTTCA	0.368000													35	53					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141461232	141461232	+	Missense_Mutation	SNP	T	T	A	rs139039328		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr8:141461232T>A	ENST00000389328.4	-	2	549	c.535A>T	c.(535-537)Atc>Ttc	p.I179F	TRAPPC9_ENST00000438773.2_Missense_Mutation_p.I81F|TRAPPC9_ENST00000389327.3_Missense_Mutation_p.I81F	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	81					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						GTGATGGTGATGAGGCCCACG	0.582000													36	136					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	24231384	24231384	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr16:24231384G>A	ENST00000321728.7	+	17	2141	c.1966G>A	c.(1966-1968)Gaa>Aaa	p.E656K	PRKCB_ENST00000303531.7_3'UTR	NM_212535.2	NP_997700.1	P05771	KPCB_HUMAN	protein kinase C, beta	656	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	GGACCAAAATGAATTTGCTGG	0.448000													58	67					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	374007	374007	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:374007C>A	ENST00000342640.4	-	3	478	c.436G>T	c.(436-438)Gga>Tga	p.G146*	THEG_ENST00000346878.2_Intron	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	146					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACAGCGTCCCTTCCTGCGA	0.607000													11	22					1.58986e-06	1.63474e-06	1	1	0
INSRR	3645	broad.mit.edu	37	1	156823923	156823923	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:156823923G>A	ENST00000368195.3	-	2	654	c.258C>T	c.(256-258)ttC>ttT	p.F86F	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	86					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CGTAGACACGGAAGAGCAGCA	0.627000													34	37					0	0	1	0	0
PPP2R5B	5526	broad.mit.edu	37	11	64695303	64695303	+	Silent	SNP	G	G	A	rs139405284	byFrequency	TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:64695303G>A	ENST00000164133.2	+	4	1048	c.426G>A	c.(424-426)ccG>ccA	p.P142P		NM_006244.3	NP_006235.1	Q15173	2A5B_HUMAN	protein phosphatase 2, regulatory subunit B', beta	142					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(2)	21						GGACTCTGCCGCCCAGTGAGA	0.517000													36	54					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70944628	70944628	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr6:70944628C>T	ENST00000357250.6	-	34	2286	c.2128G>A	c.(2128-2130)Gaa>Aaa	p.E710K	RP1-149L1.1_ENST00000522264.1_RNA|COL9A1_ENST00000489611.1_5'UTR|COL9A1_ENST00000370499.4_Missense_Mutation_p.E467K|COL9A1_ENST00000320755.7_Missense_Mutation_p.E467K	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	710	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding	p.E710*(1)|p.E467*(1)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AAGCCAGGTTCCCCAGGATTA	0.527000													24	49					0	0	1	0	0
COX10	1352	broad.mit.edu	37	17	13980197	13980197	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr17:13980197C>T	ENST00000261643.3	+	3	400	c.323C>T	c.(322-324)tCt>tTt	p.S108F	COX10_ENST00000537334.1_Intron|COX10_ENST00000536205.1_5'UTR|COX10_ENST00000429152.2_Missense_Mutation_p.S108F	NM_001303.3	NP_001294.2	Q12887	COX10_HUMAN	cytochrome c oxidase assembly homolog 10 (yeast)	108					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		CCCAGCCTATCTTTGTCCAGA	0.413000													74	51					0	0	1	0	0
ZNF157	7712	broad.mit.edu	37	X	47269689	47269689	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chrX:47269689C>T	ENST00000377073.3	+	2	173	c.87C>T	c.(85-87)ttC>ttT	p.F29F		NM_003446.3	NP_003437.2	P51786	ZN157_HUMAN	zinc finger protein 157	29	KRAB.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						CCGTGTCATTCGAGGATGTGG	0.498000													62	8					0	0	1	0	0
GPR32	2854	broad.mit.edu	37	19	51274185	51274185	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:51274185G>A	ENST00000270590.4	+	1	465	c.328G>A	c.(328-330)Gga>Aga	p.G110R		NM_001506.1	NP_001497.1	O75388	GPR32_HUMAN	G protein-coupled receptor 32	110						integral to plasma membrane	N-formyl peptide receptor activity			breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GTGGCTCCTCGGAGAGTGGGC	0.527000													44	56					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33999485	33999485	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:33999485C>T	ENST00000373381.4	-	63	10078	c.9902G>A	c.(9901-9903)cGt>cAt	p.R3301H		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3157						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTTTTGACAACGGAAGAGGAC	0.562000													21	30					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69965095	69965095	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr16:69965095C>T	ENST00000359154.2	+	14	1587	c.1486C>T	c.(1486-1488)Cgg>Tgg	p.R496W	WWP2_ENST00000448661.1_Missense_Mutation_p.R496W|WWP2_ENST00000356003.2_Missense_Mutation_p.R496W|WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000542271.1_Missense_Mutation_p.R380W|WWP2_ENST00000568684.1_Missense_Mutation_p.R57W	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	496					entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CCGCAGTTTTCGGTGGAAGTA	0.488000													83	98					0	0	1	0	0
SUCO	51430	broad.mit.edu	37	1	172501872	172501872	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:172501872G>A	ENST00000367723.3	+	1	384	c.260G>A	c.(259-261)cGa>cAa	p.R87Q		NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		AGAGAAAAACGAATTCTGGAA	0.517000													27	28					0	0	1	0	0
PDE8A	5151	broad.mit.edu	37	15	85679817	85679817	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:85679817G>A	ENST00000310298.4	+	22	2558	c.2306G>A	c.(2305-2307)aGa>aAa	p.R769K	PDE8A_ENST00000339708.5_Missense_Mutation_p.R723K|PDE8A_ENST00000394553.1_Missense_Mutation_p.R769K|PDE8A_ENST00000557957.1_Missense_Mutation_p.R697K			O60658	PDE8A_HUMAN	phosphodiesterase 8A	769	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	25	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			GTGTTTGACAGAAATACCTGC	0.428000													31	92					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141461233	141461233	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr8:141461233G>A	ENST00000389328.4	-	2	548	c.534C>T	c.(532-534)ctC>ctT	p.L178L	TRAPPC9_ENST00000438773.2_Silent_p.L80L|TRAPPC9_ENST00000389327.3_Silent_p.L80L	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	80					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						TGATGGTGATGAGGCCCACGA	0.582000													39	136					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38406299	38406299	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:38406299G>A	ENST00000322350.5	+	7	1130	c.784G>A	c.(784-786)Gaa>Aaa	p.E262K	EGFLAM_ENST00000336740.6_Missense_Mutation_p.E28K|EGFLAM_ENST00000354891.3_Missense_Mutation_p.E262K|EGFLAM_ENST00000397202.2_Intron	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	262						cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TGAGGATGATGAAGGATTTGA	0.473000													14	28					0	0	1	0	0
SPANXD	64648	broad.mit.edu	37	X	140785745	140785745	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chrX:140785745C>T	ENST00000370515.3	-	2	504	c.171G>A	c.(169-171)agG>agA	p.R57R		NM_032417.2|NM_145665.1	NP_115793.1|NP_663698.1			SPANX family, member D											breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	9	Acute lymphoblastic leukemia(192;7.65e-05)					TTTTAAAGTTCCTCCTGTAGC	0.483000													151	236					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52003224	52003224	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:52003224C>T	ENST00000291707.3	-	2	813	c.758G>A	c.(757-759)gGa>gAa	p.G253E	SIGLEC12_ENST00000598614.1_Missense_Mutation_p.G135E	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	253	Ig-like V-type 2.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TTTCCTGCTTCCTCTCTCCAC	0.547000													43	76					0	0	1	0	0
OTOR	56914	broad.mit.edu	37	20	16730648	16730648	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr20:16730648C>T	ENST00000246081.2	+	3	400	c.356C>T	c.(355-357)cCc>cTc	p.P119L	OTOR_ENST00000486129.1_3'UTR	NM_020157.2	NP_064542.1	Q9NRC9	OTOR_HUMAN	otoraplin	119					sensory perception of sound	extracellular region				breast(1)|central_nervous_system(1)|endometrium(1)|liver(4)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10						AAGGAAGTTCCCACCACGGTA	0.478000													15	28					0	0	1	0	0
TRAV20	28663	broad.mit.edu	37	14	22508879	22508879	+	RNA	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:22508879C>T	ENST00000390448.3	+	0	40																											TTGGAATTATCGTAATTTGTT	0.418000													41	87					0	0	1	0	0
KRTAP5-7	440050	broad.mit.edu	37	11	71238615	71238615	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:71238615G>A	ENST00000398536.4	+	1	303	c.269G>A	c.(268-270)tGt>tAt	p.C90Y		NM_001012503.1	NP_001012521.1	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	90	7 X 4 AA repeats of C-C-X-P.					keratin filament				breast(1)|endometrium(1)|kidney(3)|lung(6)|ovary(1)	12						TGTGGTTCTTGTGgctgctcc	0.647000													6	300					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73074795	73074795	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:73074795C>T	ENST00000263674.3	+	16	5600	c.5250C>T	c.(5248-5250)gtC>gtT	p.V1750V		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1750					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						TCCACAGTGTCCACGTGTACC	0.597000													36	77					0	0	1	0	0
SCARA3	51435	broad.mit.edu	37	8	27516954	27516954	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr8:27516954C>T	ENST00000301904.3	+	5	1287	c.1267C>T	c.(1267-1269)Cgg>Tgg	p.R423W	SCARA3_ENST00000337221.4_Missense_Mutation_p.R423W	NM_016240.2	NP_057324.2	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3	423			R -> Q (in dbSNP:rs3735754).		response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			breast(1)|large_intestine(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	9		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		GCTCAGTGCCCGGCTGGACCT	0.582000													17	5					0	0	1	0	0
RPTOR	57521	broad.mit.edu	37	17	78936306	78936306	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr17:78936306G>A	ENST00000306801.3	+	32	4100	c.3738G>A	c.(3736-3738)tcG>tcA	p.S1246S	RPTOR_ENST00000575542.1_3'UTR|RPTOR_ENST00000544334.2_Silent_p.S1088S	NM_020761.2	NP_065812.1	Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	1246					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						TGCCTGAGTCGGTAAATGTGC	0.632000													6	262					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47363917	47363917	+	Missense_Mutation	SNP	A	A	G	rs138128932	by1000genomes	TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr18:47363917A>G	ENST00000285039.7	-	37	5407	c.5108T>C	c.(5107-5109)gTc>gCc	p.V1703A	RP11-886H22.1_ENST00000590532.2_Missense_Mutation_p.V26A|MYO5B_ENST00000324581.6_Missense_Mutation_p.V818A|MYO5B_ENST00000592688.1_Missense_Mutation_p.V273A|SCARNA17_ENST00000589499.1_RNA	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1703	Dilute.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity	p.V1703A(5)		NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CCAAGAGCAGACGTCCTTCCG	0.527000													5	85					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144992172	144992172	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr8:144992172G>A	ENST00000322810.4	-	32	12397	c.12228C>T	c.(12226-12228)ttC>ttT	p.F4076F	PLEC_ENST00000398774.2_Silent_p.F3907F|PLEC_ENST00000345136.3_Silent_p.F3939F|PLEC_ENST00000436759.2_Silent_p.F3966F|PLEC_ENST00000356346.3_Silent_p.F3925F|PLEC_ENST00000354958.2_Silent_p.F3917F|PLEC_ENST00000354589.3_Silent_p.F3939F|PLEC_ENST00000527096.1_Silent_p.F3962F|PLEC_ENST00000357649.2_Silent_p.F3943F	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4076	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						TGGCGTCCACGAAGACACCAG	0.642000													13	55					0	0	1	0	0
ADAM10	102	broad.mit.edu	37	15	58904163	58904163	+	Silent	SNP	T	T	C			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:58904163T>C	ENST00000260408.3	-	12	1982	c.1539A>G	c.(1537-1539)gcA>gcG	p.A513A	ADAM10_ENST00000402627.1_Intron|ADAM10_ENST00000396140.2_Silent_p.A212A|ADAM10_ENST00000561288.1_Intron	NM_001110.2	NP_001101.1	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10	513	Disintegrin.				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			breast(1)|endometrium(1)|kidney(5)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)	27				GBM - Glioblastoma multiforme(80;0.202)		ATGCACACTGTGCTGTACAAC	0.393000													26	39					0	0	1	0	0
GRTP1	79774	broad.mit.edu	37	13	114005241	114005241	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr13:114005241C>T	ENST00000375430.4	-	4	434	c.388G>A	c.(388-390)Gac>Aac	p.D130N	GRTP1_ENST00000375431.4_Missense_Mutation_p.D130N|GRTP1_ENST00000326039.3_Missense_Mutation_p.D52N			Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	130	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	14	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			AAGCAGGGGTCCGTGGTCTTC	0.582000													101	143					0	0	1	0	0
RHPN1	114822	broad.mit.edu	37	8	144461589	144461589	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr8:144461589G>A	ENST00000289013.6	+	8	957	c.856G>A	c.(856-858)Gaa>Aaa	p.E286K		NM_052924.2	NP_443156.2	Q8TCX5	RHPN1_HUMAN	rhophilin, Rho GTPase binding protein 1	286	BRO1.				signal transduction	intracellular				endometrium(1)|large_intestine(1)|lung(7)	9	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			CCAGGCCCAGGAATGTGTGTT	0.672000													4	22					0	0	1	0	0
SULT1E1	6783	broad.mit.edu	37	4	70721092	70721092	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr4:70721092C>T	ENST00000226444.3	-	3	310	c.198G>A	c.(196-198)gtG>gtA	p.V66V		NM_005420.2	NP_005411.1	P49888	ST1E1_HUMAN	sulfotransferase family 1E, estrogen-preferring, member 1	66					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	10						TGCACTTTTCCACATCACCCT	0.348000													26	37					0	0	1	0	0
SOGA1	140710	broad.mit.edu	37	20	35433156	35433156	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr20:35433156G>A	ENST00000237536.4	-	10	3410	c.3069C>T	c.(3067-3069)ctC>ctT	p.L1023L	SOGA1_ENST00000279034.5_Silent_p.L785L|SOGA1_ENST00000456801.2_Silent_p.L626L|SOGA1_ENST00000357779.3_Silent_p.L785L	NM_080627.2	NP_542194.2	O94964	K0889_HUMAN	suppressor of glucose, autophagy associated 1	785										endometrium(5)|kidney(1)|lung(21)|urinary_tract(1)	28						TATGGCCCTTGAGCTCTGCCC	0.597000													68	48					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832853	61832853	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr10:61832853G>A	ENST00000280772.1	-	37	7977	c.7786C>T	c.(7786-7788)Cgt>Tgt	p.R2596C	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2596					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GTTTTGTCACGAAAAAACTGT	0.418000													108	16					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19337547	19337547	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:19337547C>T	ENST00000252575.5	+	7	1368	c.1325C>T	c.(1324-1326)cCc>cTc	p.P442L		NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	442					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GCCTCATGGCCCACTGGGGAA	0.622000													22	22					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802800	185802800	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:185802800G>A	ENST00000302277.6	+	4	3271	c.2677G>A	c.(2677-2679)Ggt>Agt	p.G893S		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	893						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TGAAACCAATGGTGAAACTGA	0.403000													93	70					0	0	1	0	0
TMEM218	219854	broad.mit.edu	37	11	124967550	124967550	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:124967550G>A	ENST00000455225.1	-	4	951	c.300C>T	c.(298-300)atC>atT	p.I100I	TMEM218_ENST00000532407.1_Silent_p.I100I|TMEM218_ENST00000532156.1_3'UTR|TMEM218_ENST00000531909.1_Silent_p.I100I|TMEM218_ENST00000531262.1_5'UTR|TMEM218_ENST00000529609.1_3'UTR|TMEM218_ENST00000528724.1_Silent_p.I126I|TMEM218_ENST00000527766.1_Silent_p.I100I|TMEM218_ENST00000527271.1_Silent_p.I100I|TMEM218_ENST00000526175.1_Silent_p.I100I|TMEM218_ENST00000529583.1_Silent_p.I100I|TMEM218_ENST00000279968.4_Silent_p.I100I			A2RU14	TM218_HUMAN	transmembrane protein 218	100						integral to membrane				breast(1)|large_intestine(2)|lung(1)|prostate(1)	5						GAACATAATGGATTAAAACCA	0.448000													20	35					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55539569	55539569	+	Missense_Mutation	SNP	G	G	A	rs35613782		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr8:55539569G>A	ENST00000220676.1	+	4	3275	c.3127G>A	c.(3127-3129)Gaa>Aaa	p.E1043K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1043					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TATAGCTGCTGAAAAATCAGG	0.373000													88	114					0	0	1	0	0
BIRC5	332	broad.mit.edu	37	17	76219645	76219645	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr17:76219645C>T	ENST00000600484.1	-	5	634	c.635G>A	c.(634-636)gGc>gAc	p.G212D	BIRC5_ENST00000301633.4_3'UTR|BIRC5_ENST00000374948.2_Silent_p.G107G|BIRC5_ENST00000350051.3_3'UTR|BIRC5_ENST00000589892.1_3'UTR																							AGGCCTCTGGCCGGAGCTGCC	0.557000													54	26					0	0	1	0	0
ERLIN1	10613	broad.mit.edu	37	10	101935808	101935808	+	Missense_Mutation	SNP	G	G	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr10:101935808G>T	ENST00000421367.2	-	5	3031	c.324C>A	c.(322-324)aaC>aaA	p.N108K	ERLIN1_ENST00000407654.3_Missense_Mutation_p.N108K	NM_001100626.1|NM_006459.3	NP_001094096.1|NP_006450.2	O75477	ERLN1_HUMAN	ER lipid raft associated 1	106					ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding						Colorectal(252;0.234)		Epithelial(162;3.85e-10)|all cancers(201;3.25e-08)		CTGCAGTATAGTTCCTCACGA	0.413000													36	5					2.09667e-21	2.21846e-21	1	1	0
SPOCK1	6695	broad.mit.edu	37	5	136315117	136315117	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:136315117C>T	ENST00000394945.1	-	10	1202	c.1033G>A	c.(1033-1035)Gcc>Acc	p.A345T	SPOCK1_ENST00000509978.1_5'UTR|SPOCK1_ENST00000282223.7_Missense_Mutation_p.A345T	NM_004598.3	NP_004589.1	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	345	Thyroglobulin type-1.				cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CACTGTGTGGCTTTGTAATAG	0.527000													33	58					0	0	1	0	0
DVL3	1857	broad.mit.edu	37	3	183888427	183888427	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr3:183888427C>T	ENST00000313143.3	+	15	2283	c.2035C>T	c.(2035-2037)Cca>Tca	p.P679S	DVL3_ENST00000431765.1_Missense_Mutation_p.P662S|EIF2B5_ENST00000444495.1_Intron	NM_004423.3	NP_004414.3	Q92997	DVL3_HUMAN	dishevelled segment polarity protein 3	679					canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(6)|liver(1)|lung(13)|ovary(1)|prostate(1)	35	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CATGGGGCCCCCAGGAGCCCC	0.706000													35	10					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2413193	2413193	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr20:2413193C>T	ENST00000202625.2	+	13	2086	c.2025C>T	c.(2023-2025)tcC>tcT	p.S675S	TGM6_ENST00000381423.1_3'UTR	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	675					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	TCACCCCCTCCAAAAGTGGCC	0.587000													64	138					0	0	1	0	0
HLA-B	3106	broad.mit.edu	37	6	31323290	31323290	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr6:31323290G>T	ENST00000412585.2	-	4	727	c.699C>A	c.(697-699)taC>taA	p.Y233*		NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B											endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						TCTCCGCAGGGTAGAAACCCA	0.582000									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				71	100					2.84776e-26	3.0384e-26	1	1	0
FLT4	2324	broad.mit.edu	37	5	180048620	180048620	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:180048620C>T	ENST00000261937.6	-	13	2020	c.1942G>A	c.(1942-1944)Gag>Aag	p.E648K	FLT4_ENST00000502649.1_Missense_Mutation_p.E648K|FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000393347.3_Missense_Mutation_p.E648K	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	648	Ig-like C2-type 6.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TAGTGGCCCTCGTGCTCGGGC	0.692000													27	24					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45809381	45809381	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr22:45809381G>A	ENST00000357450.4	-	1	67	c.68C>T	c.(67-69)cCc>cTc	p.P23L	SMC1B_ENST00000404354.3_Missense_Mutation_p.P23L	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	23					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CCTCCGGAAGGGGCCAATGAC	0.672000													24	13					0	0	1	0	0
STIM2	57620	broad.mit.edu	37	4	27019506	27019506	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr4:27019506C>T	ENST00000382009.3	+	12	2215	c.1948C>T	c.(1948-1950)Cct>Tct	p.P650S	STIM2_ENST00000412829.2_Missense_Mutation_p.P642S|STIM2_ENST00000467011.1_Missense_Mutation_p.P555S|STIM2_ENST00000237364.5_Missense_Mutation_p.P642S|STIM2_ENST00000467087.1_Missense_Mutation_p.P555S|STIM2_ENST00000465503.1_Missense_Mutation_p.P563S	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	555					activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				ACACTCCTTGCCTTCCCCTGA	0.572000													5	277					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92533014	92533014	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:92533014G>A	ENST00000298047.6	+	9	6852	c.6835G>A	c.(6835-6837)Gat>Aat	p.D2279N	FAT3_ENST00000525166.1_Missense_Mutation_p.D2129N|FAT3_ENST00000409404.2_Missense_Mutation_p.D2279N			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2279	Cadherin 20.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTAGTTAATGATGTAAATGA	0.413000										TCGA Ovarian(4;0.039)			12	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179419272	179419272	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:179419272C>T	ENST00000589042.1	-	332	89026	c.88802G>A	c.(88801-88803)gGa>gAa	p.G29601E	TTN_ENST00000460472.2_Missense_Mutation_p.G20536E|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G27960E|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G20661E|TTN_ENST00000342992.6_Missense_Mutation_p.G27033E|TTN_ENST00000342175.6_Missense_Mutation_p.G20728E|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	27960	Ig-like 135.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTATTCATTTCCTTTGATAAT	0.453000													67	38					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51729317	51729317	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:51729317C>T	ENST00000436584.2	+	2	351	c.296C>T	c.(295-297)aCc>aTc	p.T99I	CD33_ENST00000391796.3_Missense_Mutation_p.T226I|CD33_ENST00000421133.2_Missense_Mutation_p.T99I|CD33_ENST00000262262.4_Missense_Mutation_p.T226I			P20138	CD33_HUMAN	CD33 molecule	226	Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	ACGGAGAGAACCATCCAGCTC	0.602000													24	39					0	0	1	0	0
PTPRH	5794	broad.mit.edu	37	19	55711789	55711789	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:55711789G>A	ENST00000376350.3	-	7	1257	c.1235C>T	c.(1234-1236)cCa>cTa	p.P412L	PTPRH_ENST00000588559.1_5'UTR|PTPRH_ENST00000263434.5_Missense_Mutation_p.P234L	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	412	Fibronectin type-III 5.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CTGAGGGTATGGGCCATCGGG	0.537000													53	61					0	0	1	0	0
GOT1L1	137362	broad.mit.edu	37	8	37794544	37794544	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr8:37794544C>T	ENST00000307599.4	-	5	650	c.551G>A	c.(550-552)gGg>gAg	p.G184E		NM_152413.2	NP_689626.2	Q8NHS2	AATC2_HUMAN	glutamic-oxaloacetic transaminase 1-like 1	184					biosynthetic process|cellular amino acid metabolic process	cytoplasm	pyridoxal phosphate binding|transaminase activity			central_nervous_system(1)|endometrium(3)|lung(8)|ovary(1)|prostate(1)	14	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)			GATAATGTTCCCCATCACAAG	0.552000													26	130					0	0	1	0	0
SCAPER	49855	broad.mit.edu	37	15	76726424	76726424	+	Silent	SNP	A	A	G			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:76726424A>G	ENST00000538941.2	-	26	3507	c.2568T>C	c.(2566-2568)ctT>ctC	p.L856L	SCAPER_ENST00000324767.7_Silent_p.L1102L|SCAPER_ENST00000563290.1_Silent_p.L1102L	NM_001145923.1	NP_001139395.1	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	1101						endoplasmic reticulum|nucleus	zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(16)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	39						TTTACCTGATAAGGTCCTGAA	0.373000													22	34					0	0	1	0	0
NDST3	9348	broad.mit.edu	37	4	119035960	119035960	+	Splice_Site	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr4:119035960G>A	ENST00000296499.5	+	4	1472		c.e4-1		NDST3_ENST00000433996.2_Intron	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3							Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						CCCCCCTAAAGGAACTGAAGA	0.398000													30	51					0	0	1	0	0
DCAF6	55827	broad.mit.edu	37	1	167962653	167962653	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:167962653C>T	ENST00000367840.3	+	7	972	c.878C>T	c.(877-879)cCt>cTt	p.P293L	DCAF6_ENST00000432587.2_Missense_Mutation_p.P262L|DCAF6_ENST00000367843.3_Missense_Mutation_p.P293L|DCAF6_ENST00000312263.6_Missense_Mutation_p.P293L	NM_001198956.1	NP_001185885.1	Q58WW2	DCAF6_HUMAN	DDB1 and CUL4 associated factor 6	293					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	36						CTTAAAACTCCTTCTGCGGAA	0.468000													44	47					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126249485	126249485	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:126249485C>T	ENST00000405249.1	-	8	1495	c.1496G>A	c.(1495-1497)aGt>aAt	p.S499N	GRM8_ENST00000358373.3_Silent_p.Q475Q|GRM8_ENST00000339582.2_Silent_p.Q475Q|GRM8_ENST00000444921.2_Silent_p.Q475Q|GRM8_ENST00000480995.1_Intron			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	0					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TTATTTGATACTGGAAGATAT	0.363000										HNSCC(24;0.065)			95	12					0	0	1	0	0
SLC25A52	147407	broad.mit.edu	37	18	29339741	29339741	+	Missense_Mutation	SNP	T	T	G			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr18:29339741T>G	ENST00000269205.5	-	1	1102	c.914A>C	c.(913-915)aAa>aCa	p.K305T	SLC25A52_ENST00000579441.2_Missense_Mutation_p.K295T	NM_001034172.2	NP_001029344.3	Q3SY17	MCAR2_HUMAN	solute carrier family 25, member 52	295					transport	integral to membrane|mitochondrial inner membrane											TCATATAAATTTTAACAAGAA	0.358000													45	58					0	0	1	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205312652	205312652	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:205312652C>T	ENST00000367156.3	-	5	897	c.81G>A	c.(79-81)ctG>ctA	p.L27L	KLHDC8A_ENST00000460687.1_Intron|KLHDC8A_ENST00000537168.1_Intron|KLHDC8A_ENST00000367155.3_Silent_p.L27L|KLHDC8A_ENST00000539253.1_Silent_p.L27L	NM_001271863.1	NP_001258792.1	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	27										breast(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CCCCGGTCTCCAGCAGGGAGC	0.677000													27	42					0	0	1	0	0
ZSCAN5A	79149	broad.mit.edu	37	19	56733512	56733512	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:56733512G>A	ENST00000587340.1	-	7	1618	c.923C>T	c.(922-924)tCc>tTc	p.S308F	ZSCAN5A_ENST00000592355.1_Missense_Mutation_p.S307F|ZSCAN5A_ENST00000587492.1_Missense_Mutation_p.S162F|ZSCAN5A_ENST00000391713.1_Missense_Mutation_p.S308F|ZSCAN5A_ENST00000254165.3_Missense_Mutation_p.S191F			Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	308					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						CTCTTCTTGGGAAATGGAGGA	0.547000													64	105					0	0	1	0	0
NR2E3	10002	broad.mit.edu	37	15	72110079	72110079	+	RNA	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:72110079G>A	ENST00000563709.1	+	0	279																											ctactgaaacgaaacatttgc	0.428000													4	8					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210977336	210977336	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:210977336G>A	ENST00000367007.4	-	8	1723	c.1554C>T	c.(1552-1554)tcC>tcT	p.S518S	KCNH1_ENST00000271751.4_Silent_p.S545S	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	545					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CTCTGGACATGGACCAAGTGG	0.483000													52	152					0	0	1	0	0
PAH	5053	broad.mit.edu	37	12	103234250	103234250	+	Missense_Mutation	SNP	C	C	T	rs62644499		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr12:103234250C>T	ENST00000553106.1	-	12	1715	c.1243G>A	c.(1243-1245)Gac>Aac	p.D415N	PAH_ENST00000307000.2_Missense_Mutation_p.D410N	NM_000277.1	NP_000268.1	P00439	PH4H_HUMAN	phenylalanine hydroxylase	415			D -> N (in non-PKU HPA; haplotype 1).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(5)|skin(2)|urinary_tract(1)	27					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	GTGTATGGGTCGTAGCGAACT	0.463000													4	144					0	0	1	0	0
RASAL2	9462	broad.mit.edu	37	1	178427427	178427427	+	Missense_Mutation	SNP	G	G	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:178427427G>T	ENST00000448150.3	+	14	3785	c.2967G>T	c.(2965-2967)ttG>ttT	p.L989F	RASAL2_ENST00000462775.1_Missense_Mutation_p.L859F|RASAL2_ENST00000367649.3_Missense_Mutation_p.L1000F	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	859					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						CTCTTGCTTTGCCACGACAAA	0.547000													25	57					7.92952e-12	8.21963e-12	1	1	0
KCNH5	27133	broad.mit.edu	37	14	63316527	63316527	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:63316527G>A	ENST00000322893.7	-	8	1681	c.1413C>T	c.(1411-1413)ttC>ttT	p.F471F	KCNH5_ENST00000394968.1_Silent_p.F413F|KCNH5_ENST00000420622.2_Silent_p.F471F	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	471					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ACATTTGCTGGAAAATTGTTG	0.348000													75	55					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62278836	62278836	+	Splice_Site	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr3:62278836G>A	ENST00000474889.1	+	30	4569	c.4191_splice	c.e30-1	p.E1398_splice	PTPRG_ENST00000295874.10_Splice_Site_p.E1369_splice|PTPRG-AS1_ENST00000466893.1_RNA|PTPRG-AS1_ENST00000490916.1_RNA|PTPRG-AS1_ENST00000462497.1_RNA|PTPRG-AS1_ENST00000498655.1_RNA|PTPRG-AS1_ENST00000474795.1_RNA|PTPRG-AS1_ENST00000475371.1_RNA|PTPRG-AS1_ENST00000495542.1_RNA|PTPRG-AS1_ENST00000479018.1_RNA	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	1398	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		TGTTTTTCAGGAACAATACCA	0.353000													37	100					0	0	1	0	0
SNW1	22938	broad.mit.edu	37	14	78217799	78217799	+	Missense_Mutation	SNP	G	G	C			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:78217799G>C	ENST00000261531.7	-	3	255	c.193C>G	c.(193-195)Cca>Gca	p.P65A	SNW1_ENST00000555761.1_Missense_Mutation_p.P65A|SNW1_ENST00000554775.1_Intron|SLIRP_ENST00000557431.1_Intron	NM_012245.2	NP_036377.1	Q13573	SNW1_HUMAN	SNW domain containing 1	65					negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter	catalytic step 2 spliceosome|nucleoplasm	Notch binding			NS(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		TGGATCTCTGGAAAAGCACCT	0.358000													21	58					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1271331	1271331	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:1271331C>T	ENST00000447027.1	+	31	13288	c.13230C>T	c.(13228-13230)ccC>ccT	p.P4410P	MUC5B_ENST00000529681.1_Silent_p.P4407P			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4407	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCACTGGCCCCACGGCCACCC	0.662000													95	49					0	0	1	0	0
KCNIP3	30818	broad.mit.edu	37	2	96040896	96040896	+	Silent	SNP	C	C	T	rs138182369		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:96040896C>T	ENST00000295225.5	+	5	522	c.387C>T	c.(385-387)acC>acT	p.T129T	KCNIP3_ENST00000360990.3_Silent_p.T107T|KCNIP3_ENST00000468529.1_Silent_p.T103T|KCNIP3_ENST00000377181.2_3'UTR	NM_013434.4	NP_038462.1	Q9Y2W7	CSEN_HUMAN	Kv channel interacting protein 3, calsenilin	129	EF-hand 2.				apoptosis|signal transduction|transcription, DNA-dependent	endoplasmic reticulum|Golgi apparatus|nucleus|plasma membrane	calcium ion binding|DNA binding|potassium channel activity|transcription corepressor activity|voltage-gated ion channel activity			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	16				READ - Rectum adenocarcinoma(193;0.13)		ATGCCACCACCTATGCACACT	0.632000													45	114					0	0	1	0	0
MAP4K2	5871	broad.mit.edu	37	11	64564750	64564750	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:64564750G>A	ENST00000294066.2	-	18	1364	c.1273C>T	c.(1273-1275)Cca>Tca	p.P425S	MAP4K2_ENST00000377350.3_Missense_Mutation_p.P425S	NM_004579.3	NP_004570.2	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase kinase 2	425					activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(1)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(2)	8						GACTCACCTGGGGGACTGGAC	0.657000													6	13					0	0	1	0	0
KIAA0355	9710	broad.mit.edu	37	19	34818451	34818451	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:34818451C>T	ENST00000299505.6	+	4	1704	c.831C>T	c.(829-831)atC>atT	p.I277I		NM_014686.3	NP_055501.2	O15063	K0355_HUMAN	KIAA0355	277										breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	41	Esophageal squamous(110;0.162)					ACATAAAAATCGACAGTGCTT	0.398000													40	60					0	0	1	0	0
TLR3	7098	broad.mit.edu	37	4	187004088	187004088	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr4:187004088G>A	ENST00000296795.2	+	4	1352	c.1248G>A	c.(1246-1248)aaG>aaA	p.K416K	TLR3_ENST00000504367.1_Silent_p.K139K	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	416					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		ACCTAACCAAGAATAAAATCT	0.398000													24	38					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66457513	66457513	+	RNA	SNP	A	A	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr9:66457513A>T	ENST00000424345.1	+	0	67																											GCGTTTCATAAGGTCCTTCCT	0.557000													5	17					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143913207	143913207	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:143913207G>A	ENST00000409869.1	+	3	325	c.148G>A	c.(148-150)Ggg>Agg	p.G50R	ARHGAP15_ENST00000295095.6_Missense_Mutation_p.G50R			Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	50					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity	p.G50R(1)		endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		CACCGATGTCGGGAAGGTCAC	0.423000													29	90					0	0	1	0	0
APOBEC3A	200315	broad.mit.edu	37	22	39358189	39358189	+	Missense_Mutation	SNP	C	C	A	rs150770813		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr22:39358189C>A	ENST00000402255.1	+	5	760	c.556C>A	c.(556-558)Ctg>Atg	p.L186M	APOBEC3A_ENST00000249116.2_Missense_Mutation_p.L186M					apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A											large_intestine(1)|lung(2)|ovary(1)|skin(1)	5	Melanoma(58;0.04)					CAGCCAAGCCCTGAGTGGGAG	0.632000													4	164					8.12818e-05	8.29075e-05	1	1	0
DYX1C1	161582	broad.mit.edu	37	15	55722907	55722907	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:55722907C>T	ENST00000348518.3	-	9	1485	c.1118G>A	c.(1117-1119)aGa>aAa	p.R373K	DYX1C1_ENST00000380679.1_Intron|DYX1C1_ENST00000448430.2_Intron|DYX1C1_ENST00000321149.3_Silent_p.K408K|DYX1C1_ENST00000457155.2_Missense_Mutation_p.R373K|DYX1C1-CCPG1_ENST00000565113.1_RNA	NM_001033559.2	NP_001028731.1	Q8WXU2	DYXC1_HUMAN	dyslexia susceptibility 1 candidate 1	0					neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		CATTCCGAATCTTCTCAGCAT	0.313000													39	56					0	0	1	0	0
STOX2	56977	broad.mit.edu	37	4	184931459	184931459	+	Silent	SNP	A	A	C			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr4:184931459A>C	ENST00000308497.4	+	3	2903	c.1468A>C	c.(1468-1470)Aga>Cga	p.R490R	STOX2_ENST00000438269.1_Silent_p.R490R	NM_020225.1	NP_064610.1	Q9P2F5	STOX2_HUMAN	storkhead box 2	490					embryo development|maternal placenta development					breast(1)|endometrium(7)|lung(6)	14		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		AGCCAAGGAGAGATCCAGGTC	0.562000													8	10					0	0	1	0	0
SVOPL	136306	broad.mit.edu	37	7	138313002	138313002	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:138313002C>T	ENST00000421622.1	-	7	818	c.610G>A	c.(610-612)Ggg>Agg	p.G204R	SVOPL_ENST00000419765.3_Missense_Mutation_p.G324R|SVOPL_ENST00000436657.1_Missense_Mutation_p.G172R|SVOPL_ENST00000288513.5_Missense_Mutation_p.G172R			Q8N434	SVOPL_HUMAN	SVOP-like	324						integral to membrane	transmembrane transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	19						GAGTCCCCCCCAGTCACCACC	0.557000													67	42					0	0	1	0	0
CHRNB2	1141	broad.mit.edu	37	1	154548373	154548373	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:154548373C>T	ENST00000368476.3	+	6	1738	c.1474C>T	c.(1474-1476)Ctc>Ttc	p.L492F		NM_000748.2	NP_000739.1	P17787	ACHB2_HUMAN	cholinergic receptor, nicotinic, beta 2 (neuronal)	492					B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|skin(1)|urinary_tract(3)	28	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	CACCACCTTCCTCCACTCAGA	0.567000													75	97					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611143	179611143	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:179611143C>T	ENST00000360870.5	-	46	16206	c.15984G>A	c.(15982-15984)gtG>gtA	p.V5328V	TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000589042.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8840	Ig-like 34.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCACTATTTTCACCTGCTTCT	0.348000													34	57					0	0	1	0	0
YIPF5	81555	broad.mit.edu	37	5	143541788	143541788	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:143541788G>A	ENST00000274496.5	-	5	739	c.605C>T	c.(604-606)tCt>tTt	p.S202F	YIPF5_ENST00000513112.1_Missense_Mutation_p.S148F|YIPF5_ENST00000448443.2_Missense_Mutation_p.S202F	NM_001271732.1|NM_030799.7	NP_001258661.1|NP_110426.4	Q969M3	YIPF5_HUMAN	Yip1 domain family, member 5	202					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi cisterna membrane|integral to membrane				large_intestine(2)|lung(5)|ovary(1)|skin(1)	9		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			TTACTGCAAAGAAAATATCAC	0.388000													51	72					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78911664	78911664	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr9:78911664G>A	ENST00000545128.1	+	27	3944	c.3406G>A	c.(3406-3408)Gaa>Aaa	p.E1136K		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	843					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						CCGAGCATGCGAAACCTGCAC	0.562000													65	11					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247063751	247063751	+	Missense_Mutation	SNP	C	C	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:247063751C>A	ENST00000366508.1	-	9	1379	c.1243G>T	c.(1243-1245)Gtt>Ttt	p.V415F	AHCTF1_ENST00000391829.2_Missense_Mutation_p.V380F|AHCTF1_ENST00000326225.3_Missense_Mutation_p.V389F			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	380	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			AAGACTGAAACACTAGTGTCA	0.348000													29	64					3.65163e-15	3.83196e-15	1	1	0
DACT1	51339	broad.mit.edu	37	14	59112763	59112763	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:59112763C>T	ENST00000395153.3	+	4	1458	c.1311C>T	c.(1309-1311)tcC>tcT	p.S437S	DACT1_ENST00000395151.3_Silent_p.S193S|DACT1_ENST00000556859.1_Silent_p.S193S|DACT1_ENST00000335867.4_Silent_p.S474S|DACT1_ENST00000541264.2_Silent_p.S193S	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	474					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						CAGGGGAGTCCCCTAAGGAAA	0.597000													143	83					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143913208	143913208	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:143913208G>A	ENST00000409869.1	+	3	326	c.149G>A	c.(148-150)gGg>gAg	p.G50E	ARHGAP15_ENST00000295095.6_Missense_Mutation_p.G50E			Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	50					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		ACCGATGTCGGGAAGGTCACT	0.423000													29	89					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3738956	3738956	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:3738956G>A	ENST00000541714.2	+	13	1917	c.1455G>A	c.(1453-1455)gaG>gaA	p.E485E	TJP3_ENST00000589378.1_Silent_p.E494E|TJP3_ENST00000262968.9_Silent_p.E518E|TJP3_ENST00000587686.1_Silent_p.E504E|TJP3_ENST00000382008.3_Silent_p.E499E|TJP3_ENST00000539908.2_Silent_p.E449E	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	499						tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCACTTTGAGCTGGAGCCCA	0.657000													57	70					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766957	77766957	+	Missense_Mutation	SNP	A	A	C			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr8:77766957A>C	ENST00000521891.2	+	10	8248	c.7800A>C	c.(7798-7800)gaA>gaC	p.E2600D	ZFHX4_ENST00000518282.1_Missense_Mutation_p.E2574D|ZFHX4_ENST00000050961.6_Missense_Mutation_p.E2555D|ZFHX4_ENST00000455469.2_Missense_Mutation_p.E2555D	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2555						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATAGCGGTGAAGACCAACACC	0.438000										HNSCC(33;0.089)			11	15					0	0	1	0	0
MT-CYB	4519	broad.mit.edu	37	MT	14990	14990	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chrM:14990C>T	ENST00000361789.2	+	1	244	c.244C>T	c.(244-246)Ctt>Ttt	p.82_82insF						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						TCATCCGCTACCTTCACGCCA	0.473000													102	25					0	0	1	0	0
CCDC155	147872	broad.mit.edu	37	19	49920500	49920500	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:49920500C>T	ENST00000447857.3	+	19	1729	c.1524C>T	c.(1522-1524)ctC>ctT	p.L508L		NM_144688.4	NP_653289.3	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	508						integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						GGGGCCAGCTCTGCCTGCCCC	0.662000													11	11					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74973894	74973894	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:74973894C>T	ENST00000261978.4	-	26	4281	c.3895G>A	c.(3895-3897)Gga>Aga	p.G1299R	LTBP2_ENST00000556690.1_Intron	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1299	Cys-rich.|EGF-like 14; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		ATGCAGTCTCCGTTCGGGGCC	0.552000													37	102					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862882	10862882	+	RNA	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr21:10862882C>T	ENST00000559480.1	+	0	178																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						GCACCAGGTCCATGCACAAGG	0.562000													25	312					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78381065	78381065	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:78381065G>A	ENST00000278550.7	-	32	6787	c.6325C>T	c.(6325-6327)Cgc>Tgc	p.R2109C		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TCATCATAGCGATAGAGATCA	0.488000													15	22					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166903469	166903469	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:166903469C>T	ENST00000423058.2	-	9	1205	c.1188G>A	c.(1186-1188)ggG>ggA	p.G396G	SCN1A_ENST00000303395.4_Silent_p.G396G|AC010127.3_ENST00000595268.1_RNA|AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Silent_p.G396G|SCN1A_ENST00000375405.3_Silent_p.G396G	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	396						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGTACGTTTTCCCAGCAGCAC	0.373000													47	151					0	0	1	0	0
OR51L1	119682	broad.mit.edu	37	11	5020354	5020354	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:5020354C>T	ENST00000321543.1	+	1	142	c.142C>T	c.(142-144)Ctg>Ttg	p.L48L		NM_001004755.1	NP_001004755.1	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L, member 1	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(19)|skin(2)|stomach(1)	31		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTTACCATCCTGTCTGTCAT	0.438000													59	130					0	0	1	0	0
SQSTM1	8878	broad.mit.edu	37	5	179252214	179252214	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:179252214C>T	ENST00000389805.4	+	5	920	c.742C>T	c.(742-744)Ctt>Ttt	p.L248F	SQSTM1_ENST00000360718.5_Missense_Mutation_p.L164F|SQSTM1_ENST00000510187.1_Missense_Mutation_p.L248F|SQSTM1_ENST00000402874.3_Missense_Mutation_p.L164F|SQSTM1_ENST00000376929.3_Missense_Mutation_p.L164F	NM_003900.4	NP_003891.1	Q13501	SQSTM_HUMAN	sequestosome 1	248					anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)|liver(2)|lung(5)|ovary(1)	13	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCAGCTGCCCTTAGCCCTCT	0.468000													41	61					0	0	1	0	0
UST	10090	broad.mit.edu	37	6	149395162	149395162	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr6:149395162C>T	ENST00000367463.4	+	8	1234	c.1131C>T	c.(1129-1131)ttC>ttT	p.F377F	UST_ENST00000466695.1_3'UTR	NM_005715.2	NP_005706.1	Q9Y2C2	UST_HUMAN	uronyl-2-sulfotransferase	377					protein sulfation	Golgi membrane|integral to membrane	sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(4)|lung(2)|ovary(2)	12		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.78e-10)|GBM - Glioblastoma multiforme(68;0.138)		GGCCACACTTCTTTATCCCAA	0.483000													46	8					0	0	1	0	0
RPAP1	26015	broad.mit.edu	37	15	41819264	41819264	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:41819264G>A	ENST00000304330.4	-	14	1865	c.1749C>T	c.(1747-1749)gtC>gtT	p.V583V	RPAP1_ENST00000561603.1_Silent_p.V583V	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	583						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GGCACTCCAGGACCTATGGGA	0.547000													38	58					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				77	69					0	0	1	0	0
SETD1A	9739	broad.mit.edu	37	16	30977066	30977066	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr16:30977066C>T	ENST00000262519.8	+	8	2550	c.1864C>T	c.(1864-1866)Cct>Tct	p.P622S		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	622	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						GGCGTCCCTTCCTCTTGGTTA	0.731000													7	12					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													5	51					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22199562	22199562	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:22199562G>A	ENST00000374695.3	-	31	3895	c.3816C>T	c.(3814-3816)ccC>ccT	p.P1272P		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1272					angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGCAGCCTATGGGCCCTGGCA	0.637000													34	50					0	0	1	0	0
HTR7P1	93164	broad.mit.edu	37	12	13155340	13155340	+	RNA	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr12:13155340C>T	ENST00000543321.1	+	0	31				HTR7P1_ENST00000535469.1_RNA																							GTGTGCAAACCTTTCGAGACT	0.512000													3	20					0	0	1	0	0
ANKFY1	51479	broad.mit.edu	37	17	4074018	4074018	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr17:4074018G>A	ENST00000341657.4	-	23	3312	c.3277C>T	c.(3277-3279)Cga>Tga	p.R1093*	ANKFY1_ENST00000570535.1_Nonsense_Mutation_p.R1135*|CYB5D2_ENST00000573984.1_Intron|ANKFY1_ENST00000574367.1_Nonsense_Mutation_p.R1094*	NM_016376.3	NP_057460.3	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	1093						endosome membrane	metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|liver(1)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						CCCAGCAGTCGGAACAGGAGC	0.567000													63	36					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541535	40541535	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:40541535G>A	ENST00000434248.1	-	5	1296	c.1231C>T	c.(1231-1233)Cat>Tat	p.H411Y	ZNF780B_ENST00000221355.6_Missense_Mutation_p.H263Y	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	411					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					ACATCAGCATGAATACTCTGG	0.358000													74	100					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35774065	35774065	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:35774065G>A	ENST00000440995.2	+	28	4005	c.4005G>A	c.(4003-4005)agG>agA	p.R1335R	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Silent_p.R1340R			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1340					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAATCAAAAGGAAAAATGAAC	0.388000													31	43					0	0	1	0	0
IMPA2	3613	broad.mit.edu	37	18	12014272	12014272	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr18:12014272C>T	ENST00000269159.3	+	5	632	c.390C>T	c.(388-390)ttC>ttT	p.F130F	IMPA2_ENST00000589238.1_5'UTR|IMPA2_ENST00000588752.1_3'UTR|IMPA2_ENST00000588927.1_5'UTR	NM_014214.2	NP_055029.1	O14732	IMPA2_HUMAN	inositol(myo)-1(or 4)-monophosphatase 2	130					inositol phosphate dephosphorylation|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|skin(2)|stomach(2)|urinary_tract(1)	12					Lithium(DB01356)	AGCTTGAATTCGGAGTGATTT	0.567000													16	21					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150649873	150649873	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:150649873G>A	ENST00000392968.2	-	4	2029	c.909C>T	c.(907-909)acC>acT	p.T303T	KCNH2_ENST00000330883.4_Silent_p.T59T|KCNH2_ENST00000430723.3_Silent_p.T399T|KCNH2_ENST00000262186.5_Silent_p.T399T			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	399					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	AATGCAGGATGGTCCAGCGGT	0.647000													104	83					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55964674	55964674	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:55964674G>A	ENST00000389286.4	-	11	2057	c.2010C>T	c.(2008-2010)acC>acT	p.T670T		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	670	Fibronectin type-III 3.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		GTAGGTCCTTGGTATCCAAGA	0.458000													33	68					0	0	1	0	0
IGHV4-34	28395	broad.mit.edu	37	14	106829652	106829652	+	RNA	SNP	A	A	G			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:106829652A>G	ENST00000390616.2	-	0	341																											CTTCAGGGAGAACTGGTTCTT	0.537000													243	201					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22855063	22855063	+	Missense_Mutation	SNP	G	G	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:22855063G>T	ENST00000283645.4	+	13	1654	c.1524G>T	c.(1522-1524)tgG>tgT	p.W508C	TUBGCP5_ENST00000559846.1_3'UTR|TUBGCP5_ENST00000453949.2_Missense_Mutation_p.W508C	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	508					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		GAGACTTCTGGTATGCAACTT	0.358000													29	47					1.13719e-10	1.17402e-10	1	1	0
OR52J3	119679	broad.mit.edu	37	11	5068032	5068032	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:5068032G>A	ENST00000380370.1	+	1	277	c.277G>A	c.(277-279)Gag>Aag	p.E93K		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E93K(1)		NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGATGCTCACGAGATTAACTA	0.488000													36	42					0	0	1	0	0
NCK1	4690	broad.mit.edu	37	3	136664754	136664754	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr3:136664754C>T	ENST00000469404.1	+	2	455	c.364C>T	c.(364-366)Cta>Tta	p.L122L	NCK1_ENST00000481752.1_Silent_p.L186L|NCK1_ENST00000288986.2_Silent_p.L186L	NM_001190796.1	NP_001177725.1	P16333	NCK1_HUMAN	NCK adaptor protein 1	186	SH3 2.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	13						CGTCAATAACCTAAATACTGG	0.423000													166	33					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40055519	40055519	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr22:40055519C>T	ENST00000336649.4	+	16	2430	c.2430C>T	c.(2428-2430)ttC>ttT	p.F810F	CACNA1I_ENST00000401624.1_Silent_p.F804F|CACNA1I_ENST00000407673.1_Silent_p.F769F|CACNA1I_ENST00000402142.3_Silent_p.F804F|CACNA1I_ENST00000404898.1_Silent_p.F769F|CACNA1I_ENST00000400164.3_Silent_p.F769F			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	804					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GGAAGAACTTCGACTCCCTGC	0.587000													15	15					0	0	1	0	0
DLGAP4	22839	broad.mit.edu	37	20	35060676	35060676	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr20:35060676G>A	ENST00000373913.3	+	3	1036	c.556G>A	c.(556-558)Gag>Aag	p.E186K	DLGAP4_ENST00000401952.2_Missense_Mutation_p.E186K|DLGAP4_ENST00000373907.2_Missense_Mutation_p.E186K|DLGAP4_ENST00000339266.5_Missense_Mutation_p.E186K			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	186					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CAAAAGCAAGGAGCGGGCCAA	0.672000													30	70					0	0	1	0	0
ZNF492	57615	broad.mit.edu	37	19	22846828	22846828	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:22846828G>A	ENST00000456783.2	+	4	601	c.357G>A	c.(355-357)gtG>gtA	p.V119V		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	119					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				ACAAATATGTGAAAGTCTTTC	0.323000													15	14					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18443873	18443873	+	Silent	SNP	C	C	G			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr12:18443873C>G	ENST00000433979.1	+	4	962	c.846C>G	c.(844-846)ctC>ctG	p.L282L	PIK3C2G_ENST00000535651.1_Silent_p.L282L|PIK3C2G_ENST00000266497.5_Silent_p.L282L|RERGL_ENST00000541632.1_Intron|PIK3C2G_ENST00000536967.1_3'UTR|PIK3C2G_ENST00000538779.1_Silent_p.L282L	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	282					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				CGTATCAGCTCTTTTCTAAGA	0.338000													12	27					0	0	1	0	0
VIPR2	7434	broad.mit.edu	37	7	158826964	158826964	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:158826964C>T	ENST00000262178.2	-	10	1096	c.911G>A	c.(910-912)cGa>cAa	p.R304Q	VIPR2_ENST00000377633.3_Missense_Mutation_p.R288Q|VIPR2_ENST00000402066.1_Missense_Mutation_p.R445Q	NM_003382.4	NP_003373.2	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	304					cell-cell signaling	integral to plasma membrane				central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		CAGCAAAATTCGTATAATACT	0.473000													35	29					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179609153	179609153	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:179609153G>A	ENST00000444136.1	+	10	1950	c.1700G>A	c.(1699-1701)gGa>gAa	p.G567E	TDRD5_ENST00000367614.1_Missense_Mutation_p.G567E|TDRD5_ENST00000294848.8_Missense_Mutation_p.G567E	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	567	Tudor.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						GGAAATATTGGAATTGTTCAG	0.403000													80	129					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16965046	16965046	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:16965046C>T	ENST00000379803.1	+	8	1046	c.1032C>T	c.(1030-1032)ctC>ctT	p.L344L	SIN3B_ENST00000596802.1_Silent_p.L344L|SIN3B_ENST00000248054.5_Silent_p.L344L	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	344	Interaction with NCOR1 (By similarity).|PAH 3.				cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						GCTCTGAGCTCCTGCAGCTCG	0.567000													33	32					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30722126	30722126	+	Missense_Mutation	SNP	C	C	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr16:30722126C>A	ENST00000262518.4	+	9	1571	c.1186C>A	c.(1186-1188)Cca>Aca	p.P396T	SRCAP_ENST00000395059.2_Missense_Mutation_p.P396T|SRCAP_ENST00000344771.4_Missense_Mutation_p.P396T	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	396	Glu-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			GCCTTGGCATCCAGATGAAGA	0.483000													20	35					0.000175454	0.00017825	1	1	0
SORCS3	22986	broad.mit.edu	37	10	107016665	107016665	+	Silent	SNP	G	G	A	rs75048624		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr10:107016665G>A	ENST00000369701.3	+	25	3653	c.3426G>A	c.(3424-3426)ttG>ttA	p.L1142L		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1142						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CTGTGTTTTTGATCTACAAGT	0.413000													35	7					0	0	1	0	0
SLC16A3	9123	broad.mit.edu	37	17	80195274	80195274	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr17:80195274C>T	ENST00000581287.1	+	3	2950	c.628C>T	c.(628-630)Ccg>Tcg	p.P210S	SLC16A3_ENST00000392341.1_Missense_Mutation_p.P210S|SLC16A3_ENST00000582743.1_Missense_Mutation_p.P210S|SLC16A3_ENST00000392339.1_Missense_Mutation_p.P210S	NM_001206951.1|NM_001206952.1	NP_001193880.1|NP_001193881.1	O15427	MOT4_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 3	210					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	GGGCTCGGGGCCGCCGCGACC	0.716000													4	19					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48369204	48369204	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr12:48369204G>A	ENST00000380518.3	-	51	3946	c.3782C>T	c.(3781-3783)tCc>tTc	p.S1261F	COL2A1_ENST00000493991.1_5'UTR|COL2A1_ENST00000337299.6_Missense_Mutation_p.S1192F	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	1261	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GTTGTTGAGGGACTTGAGTGT	0.642000													4	106					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146829338	146829338	+	Splice_Site	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:146829338G>A	ENST00000361727.3	+	8	1601	c.1083_splice	c.e8-1	p.G362_splice		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	362	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.G362E(1)		NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ATTTTACAGGGAAATTTGAGC	0.433000										HNSCC(39;0.1)			107	78					0	0	1	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183145	39183145	+	Missense_Mutation	SNP	A	A	G			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr17:39183145A>G	ENST00000361883.5	-	1	309	c.263T>C	c.(262-264)aTc>aCc	p.I88T		NM_031957.1	NP_114163.1	Q9BYS1	KRA15_HUMAN	keratin associated protein 1-5	88	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament		p.I88T(11)		central_nervous_system(1)|endometrium(2)|kidney(1)|lung(9)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	17		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGGAGCTGATCTGGCAGCA	0.632000													4	102					0	0	1	0	0
SDHAP1	255812	broad.mit.edu	37	3	195711466	195711466	+	RNA	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr3:195711466G>A	ENST00000427841.1	-	0	481					NR_003264.2																						GCCCATCACCGCGACCATGGC	0.582000													13	64					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50100852	50100852	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:50100852C>T	ENST00000418929.2	+	4	3272	c.3260C>T	c.(3259-3261)cCc>cTc	p.P1087L		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	266							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CGCGACCCACCCTTCCAGACC	0.642000													5	7					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													5	49					0	0	1	0	0
NOX4	50507	broad.mit.edu	37	11	89135611	89135611	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:89135611G>A	ENST00000535633.1	-	9	967	c.657C>T	c.(655-657)ttC>ttT	p.F219F	NOX4_ENST00000534731.1_Silent_p.F243F|NOX4_ENST00000527626.1_Silent_p.F77F|NOX4_ENST00000525196.1_Intron|NOX4_ENST00000542487.1_Silent_p.F219F|NOX4_ENST00000413594.2_Silent_p.F264F|NOX4_ENST00000343727.5_Silent_p.F219F|NOX4_ENST00000263317.4_Silent_p.F243F|NOX4_ENST00000528341.1_Silent_p.F218F|NOX4_ENST00000424319.1_Silent_p.F219F|NOX4_ENST00000527956.1_Silent_p.F219F|NOX4_ENST00000531342.1_Intron|NOX4_ENST00000375979.3_Intron|NOX4_ENST00000532825.1_Silent_p.F219F	NM_001143836.1|NM_016931.3	NP_001137308.1|NP_058627.1	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4	243	Ferric oxidoreductase.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				AATGTTCTGAGAAATACTCTG	0.433000													75	87					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151131076	151131076	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chrX:151131076C>T	ENST00000370325.1	-	4	435	c.382G>A	c.(382-384)Gac>Aac	p.D128N	GABRE_ENST00000393914.3_5'UTR|GABRE_ENST00000370328.3_Missense_Mutation_p.D128N			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	128					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					AGGCGTTCGTCGTACCAGGTC	0.463000													55	7					0	0	1	0	0
OR10G9	219870	broad.mit.edu	37	11	123894146	123894146	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:123894146C>T	ENST00000375024.1	+	1	427	c.427C>T	c.(427-429)Ctg>Ttg	p.L143L		NM_001001953.1	NP_001001953.1	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G, member 9	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(33)|prostate(2)|skin(4)|stomach(8)|urinary_tract(1)	61		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		ATGTGCCCTCCTGGCCACCAG	0.537000													63	78					0	0	1	0	0
PSG1	5669	broad.mit.edu	37	19	43373109	43373109	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:43373109C>T	ENST00000244296.2	-	4	924	c.787G>A	c.(787-789)Gaa>Aaa	p.E263K	PSG1_ENST00000403380.3_Missense_Mutation_p.E170K|PSG1_ENST00000312439.6_Missense_Mutation_p.E263K|PSG1_ENST00000595356.1_Missense_Mutation_p.E263K|PSG1_ENST00000595124.1_Missense_Mutation_p.E170K|PSG1_ENST00000436291.2_Missense_Mutation_p.E263K	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				CTCTTAGGTTCACAGGTGAAG	0.478000													117	176					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145393588	145393588	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:145393588G>A	ENST00000511217.1	+	4	1075	c.1023G>A	c.(1021-1023)atG>atA	p.M341I	SH3RF2_ENST00000359120.4_Missense_Mutation_p.M341I			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	341							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCAGCCCATGGAGAAAGCAG	0.552000													83	112					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76074504	76074504	+	RNA	SNP	C	C	T	rs146281026	by1000genomes	TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:76074504C>T	ENST00000395215.3	+	0	683																											TGAACGCACACGTGACACAGG	0.572000													4	50					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67680875	67680875	+	Splice_Site	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr16:67680875C>T	ENST00000334583.6	+	8	938	c.611_splice	c.e8+1	p.R204_splice	RLTPR_ENST00000545661.1_Splice_Site_p.R204_splice	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	204										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CCTCGGCAGTCGGTGTGTGGC	0.627000													14	18					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140732008	140732008	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:140732008C>T	ENST00000523390.1	+	1	2181	c.2181C>T	c.(2179-2181)ctC>ctT	p.L727L	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAACCGGTCTCTGCTCCAAGT	0.562000													65	100					0	0	1	0	0
MT-ND6	4541	broad.mit.edu	37	MT	14629	14629	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chrM:14629C>T	ENST00000361681.2	-	1	44	c.45G>A	c.(43-45)ggG>ggA	p.G15G						mitochondrially encoded NADH dehydrogenase 6											breast(1)|endometrium(10)|kidney(17)|urinary_tract(1)	29						AACCCCACAAACCCCATTACT	0.418000													14	82					0	0	1	0	0
TCEB3	6924	broad.mit.edu	37	1	24078489	24078489	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:24078489C>T	ENST00000418390.2	+	4	1743	c.1472C>T	c.(1471-1473)cCg>cTg	p.P491L		NM_003198.2	NP_003189.2	Q14241	ELOA1_HUMAN	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)	491					positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		TCAGAGAAGCCGGCTGGAGCT	0.488000											OREG0013232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	72					0	0	1	0	0
KRBA1	84626	broad.mit.edu	37	7	149427422	149427422	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:149427422C>T	ENST00000255992.10	+	15	2392	c.1993C>T	c.(1993-1995)Ctc>Ttc	p.L665F	KRBA1_ENST00000479560.1_3'UTR|KRBA1_ENST00000319551.8_Missense_Mutation_p.L605F|KRBA1_ENST00000485033.2_Missense_Mutation_p.L605F	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	666	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGGAAGCCGCTCCCCCAGGG	0.657000													3	6					0	0	1	0	0
OR8S1	341568	broad.mit.edu	37	12	48921776	48921776	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr12:48921776G>A	ENST00000310194.1	+	2	970	c.970G>A	c.(970-972)Gaa>Aaa	p.E324K	OR8S1_ENST00000551654.1_3'UTR	NM_001005203.2	NP_001005203.2	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S, member 1	324					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|skin(4)	22						AGCCTTCACCGAAGGCCGCAG	0.647000													4	42					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56949644	56949644	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:56949644G>A	ENST00000497933.1	+	1	424	c.277G>A	c.(277-279)Gat>Aat	p.D93N		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	63						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						CCAGGTGGTGGATTGTAGCAG	0.627000													36	48					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152660443	152660443	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr6:152660443G>A	ENST00000367255.5	-	75	12885	c.12284C>T	c.(12283-12285)tCc>tTc	p.S4095F	SYNE1_ENST00000265368.4_Missense_Mutation_p.S4095F|SYNE1_ENST00000448038.1_Missense_Mutation_p.S4024F|SYNE1_ENST00000423061.1_Missense_Mutation_p.S4024F|SYNE1_ENST00000341594.5_Missense_Mutation_p.S3960F	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4095					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding	p.S4095F(2)		NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTCACACATGGAGCAAAGGAG	0.413000										HNSCC(10;0.0054)			36	9					0	0	1	0	0
ALDH1A3	220	broad.mit.edu	37	15	101434200	101434200	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:101434200C>T	ENST00000329841.5	+	6	1111	c.579C>T	c.(577-579)ccC>ccT	p.P193P	RP11-66B24.4_ENST00000560351.1_RNA|ALDH1A3_ENST00000346623.6_Intron	NM_000693.2	NP_000684.2	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1 family, member A3	193					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(7)|lung(9)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	27	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	AGCTGGCACCCGCCCTCTGCT	0.592000													156	123					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135692793	135692793	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:135692793C>T	ENST00000513104.1	-	2	565	c.283G>A	c.(283-285)Gag>Aag	p.E95K	TRPC7_ENST00000426057.2_Missense_Mutation_p.E95K|TRPC7_ENST00000355180.3_Missense_Mutation_p.E95K	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	95					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGCAGCAGCTCCGTGACCTCT	0.602000													41	78					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82579795	82579795	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:82579795C>T	ENST00000423517.2	-	6	10446	c.10109G>A	c.(10108-10110)aGc>aAc	p.S3370N	PCLO_ENST00000437081.1_Missense_Mutation_p.S90N|PCLO_ENST00000333891.8_Missense_Mutation_p.S3370N	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3301					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CCATCCTTGGCTTTGTGGTAT	0.463000													18	52					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51900682	51900682	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr17:51900682C>T	ENST00000268919.4	+	1	444	c.288C>T	c.(286-288)tcC>tcT	p.S96S		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	96					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CGCCCTTATCCCCCTTGGCTC	0.577000													278	130					0	0	1	0	0
KRTAP10-8	386681	broad.mit.edu	37	21	46032136	46032136	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr21:46032136C>T	ENST00000334662.2	+	1	141	c.119C>T	c.(118-120)tCc>tTc	p.S40F	TSPEAR_ENST00000323084.4_Intron	NM_198695.2	NP_941968.2	P60410	KR108_HUMAN	keratin associated protein 10-8	40	19 X 5 AA repeats of C-C-X(3).					keratin filament				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	17						ACTGGCTCCTCCTGGCAGGTG	0.642000													51	72					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51772841	51772841	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:51772841G>A	ENST00000251076.5	-	24	6749	c.6462C>T	c.(6460-6462)ctC>ctT	p.L2154L	RP11-707P17.1_ENST00000561007.1_RNA|DMXL2_ENST00000543779.2_Silent_p.L2154L|DMXL2_ENST00000449909.3_Silent_p.L1518L	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2154						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		ATACTCTCAGGAGATCTTGGT	0.448000													62	83					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31767984	31767984	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:31767984G>A	ENST00000240587.4	-	2	3042	c.2715C>T	c.(2713-2715)atC>atT	p.I905I		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	905					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					GGGCCTGGAGGATCAGGAGGT	0.622000													19	37					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553887	140553887	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:140553887C>T	ENST00000231137.3	+	1	1645	c.1471C>T	c.(1471-1473)Ctg>Ttg	p.L491L		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		491	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTACTCCCTGCTGCCGTCCCA	0.657000													85	132					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52570118	52570118	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr20:52570118C>T	ENST00000395961.3	-	11	1699	c.1533G>A	c.(1531-1533)aaG>aaA	p.K511K	BCAS1_ENST00000371440.3_Silent_p.K520K|BCAS1_ENST00000434986.2_Silent_p.K177K|BCAS1_ENST00000371435.2_Silent_p.K433K	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	511						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			TGCTCTTCTGCTTGTTCATCT	0.537000													86	100					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9101918	9101918	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr3:9101918G>A	ENST00000383836.3	-	6	1225	c.798C>T	c.(796-798)atC>atT	p.I266I	SRGAP3_ENST00000360413.3_Silent_p.I266I|SRGAP3_ENST00000433332.3_5'UTR	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	266					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		AGCTCACATCGATCAGATCAG	0.537000			T	RAF1	pilocytic astrocytoma								85	15					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81230306	81230306	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:81230306G>A	ENST00000394685.3	+	25	3812	c.3393G>A	c.(3391-3393)tgG>tgA	p.W1131*	KIAA1199_ENST00000356249.5_Nonsense_Mutation_p.W1131*|RP11-351M8.2_ENST00000560873.1_RNA|KIAA1199_ENST00000220244.3_Nonsense_Mutation_p.W1131*			Q8WUJ3	K1199_HUMAN	KIAA1199	1131										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						ACTACTACTGGGACGAGGACT	0.562000													21	34					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92470126	92470126	+	Silent	SNP	T	T	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:92470126T>A	ENST00000267622.4	-	11	4567	c.4194A>T	c.(4192-4194)ctA>ctT	p.L1398L		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1398					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		GTTTCTCCTTTAGCTGCTTGA	0.368000			T	PDGFRB	AML								98	76					0	0	1	0	0
SEC22B	9554	broad.mit.edu	37	1	145103916	145103916	+	RNA	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:145103916G>A	ENST00000453618.1	+	0	411							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										AGTCTGGCCGGGACCTTCAAC	0.418000													7	33					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103155821	103155821	+	Missense_Mutation	SNP	T	T	C			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:103155821T>C	ENST00000424685.2	-	50	8089	c.7930A>G	c.(7930-7932)Aga>Gga	p.R2644G	RELN_ENST00000343529.5_Missense_Mutation_p.R2644G|RELN_ENST00000428762.1_Missense_Mutation_p.R2644G			P78509	RELN_HUMAN	reelin	2644					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CCGTCATGTCTTGGCTGCCAC	0.527000													19	47					0	0	1	0	0
C5orf20	140947	broad.mit.edu	37	5	134782587	134782587	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:134782587C>T	ENST00000503143.2	-	1	451	c.212G>A	c.(211-213)gGg>gAg	p.G71E	TIFAB_ENST00000537858.1_3'UTR	NM_130848.2	NP_570900.1	Q8TF63	DCNP1_HUMAN	chromosome 5 open reading frame 20	71						nucleus				endometrium(1)|lung(1)|prostate(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TTTGTTCCTCCCTGGAGGGTA	0.602000													16	40					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19746240	19746240	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:19746240C>T	ENST00000203556.4	-	15	1681	c.1544G>A	c.(1543-1545)gGg>gAg	p.G515E	GMIP_ENST00000586269.1_5'UTR|GMIP_ENST00000445806.2_Missense_Mutation_p.G486E|GMIP_ENST00000587238.1_Missense_Mutation_p.G489E	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	515					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						ACACTCCGTCCCGCTGACCAT	0.612000													4	113					0	0	1	0	0
NTN1	9423	broad.mit.edu	37	17	8926597	8926597	+	Missense_Mutation	SNP	G	G	C			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr17:8926597G>C	ENST00000173229.2	+	2	1014	c.907G>C	c.(907-909)Gtg>Ctg	p.V303L	NTN1_ENST00000546090.1_Missense_Mutation_p.V303L|NTN1_ENST00000538852.1_Missense_Mutation_p.V303L	NM_004822.2	NP_004813.2	O95631	NET1_HUMAN	netrin 1	303	Laminin EGF-like 1.				apoptosis|axon guidance		protein binding		NTN1/ACLY(2)	central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|lung(5)	13						CGACAGCCTGGTGTGCGACTG	0.716000													3	5					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85382242	85382242	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:85382242G>A	ENST00000258888.5	+	4	1109	c.942G>A	c.(940-942)aaG>aaA	p.K314K		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	314	Ig-like 1.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CCTGGTACAAGGATGATACGG	0.547000													21	37					0	0	1	0	0
LOX	4015	broad.mit.edu	37	5	121409712	121409712	+	Missense_Mutation	SNP	G	G	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:121409712G>T	ENST00000231004.4	-	4	1330	c.1031C>A	c.(1030-1032)aCa>aAa	p.T344K	LOX_ENST00000513319.1_5'UTR|SRFBP1_ENST00000504881.1_Intron	NM_001178102.1|NM_002317.5	NP_001171573.1|NP_002308.2	P28300	LYOX_HUMAN	lysyl oxidase	344	Lysyl-oxidase like.				protein modification process	extracellular space	copper ion binding|protein-lysine 6-oxidase activity			endometrium(1)|lung(6)|prostate(1)	8		all_cancers(142;0.0124)|Prostate(80;0.0322)|Ovarian(225;0.0814)|Breast(839;0.143)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;2.14e-11)|OV - Ovarian serous cystadenocarcinoma(64;7.87e-10)|all cancers(49;2.49e-09)|COAD - Colon adenocarcinoma(49;0.02)		ACATACCTGTGTGTGTGCAGT	0.473000													90	133					4.66267e-56	4.99572e-56	1	1	0
RBM25	58517	broad.mit.edu	37	14	73538381	73538381	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:73538381C>T	ENST00000261973.7	+	2	317	c.32C>T	c.(31-33)cCc>cTc	p.P11L	RBM25_ENST00000527432.1_Missense_Mutation_p.P11L|RBM25_ENST00000526754.1_Missense_Mutation_p.P11L|RBM25_ENST00000525321.1_Missense_Mutation_p.P11L|RBM25_ENST00000540173.1_Missense_Mutation_p.P11L	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	11					apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		AATCGCCCTCCCATGGGAATC	0.433000													37	83					0	0	1	0	0
OR4D2	124538	broad.mit.edu	37	17	56247811	56247811	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr17:56247811C>T	ENST00000545221.1	+	1	795	c.795C>T	c.(793-795)ttC>ttT	p.F265F		NM_001004707.3	NP_001004707.1	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D, member 2	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(19)|ovary(1)|skin(2)|stomach(1)	26						TCACTCCATTCCCTATGGACA	0.537000													209	82					0	0	1	0	0
TBC1D14	57533	broad.mit.edu	37	4	7006646	7006646	+	Missense_Mutation	SNP	A	A	G			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr4:7006646A>G	ENST00000409757.4	+	8	1470	c.1346A>G	c.(1345-1347)aAc>aGc	p.N449S	TBC1D14_ENST00000410031.1_Missense_Mutation_p.N221S|TBC1D14_ENST00000446947.2_Missense_Mutation_p.N62S|TBC1D14_ENST00000451522.2_Missense_Mutation_p.N169S|TBC1D14_ENST00000448507.1_Missense_Mutation_p.N449S	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	449	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						GAAGTGGAGAACGAAGGTAGA	0.458000													32	10					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206364631	206364631	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:206364631C>T	ENST00000406610.2	+	21	3263	c.3056C>T	c.(3055-3057)aCg>aTg	p.T1019M	PARD3B_ENST00000358768.2_Missense_Mutation_p.T957M|PARD3B_ENST00000351153.1_Missense_Mutation_p.T950M|PARD3B_ENST00000488622.1_3'UTR|PARD3B_ENST00000349953.3_Missense_Mutation_p.T918M	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	1019					cell cycle|cell division	endomembrane system|tight junction		p.T958M(1)		breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GGCCGTCCTACGGGTGGAAGC	0.438000													72	164					0	0	1	0	0
NEURL4	84461	broad.mit.edu	37	17	7219620	7219620	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr17:7219620G>A	ENST00000399464.2	-	29	4526	c.4511C>T	c.(4510-4512)aCg>aTg	p.T1504M	NEURL4_ENST00000570460.1_Missense_Mutation_p.T1480M|NEURL4_ENST00000315614.7_Missense_Mutation_p.T1502M|RP11-542C16.2_ENST00000575474.1_Missense_Mutation_p.R318C	NM_032442.2	NP_115818.2			neuralized E3 ubiquitin protein ligase 4											central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AGCCTGGTGCGTCCGCTGGGA	0.607000													56	35					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47423714	47423714	+	Silent	SNP	C	C	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr21:47423714C>A	ENST00000361866.3	+	35	2988	c.2874C>A	c.(2872-2874)gcC>gcA	p.A958A	COL6A1_ENST00000498614.1_3'UTR	NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	958	C-terminal globular domain.|VWFA 3.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	TCGAGAAGGCCGTGCAGGAAG	0.672000													31	40					2.61193e-14	2.71854e-14	1	1	0
OR52I2	143502	broad.mit.edu	37	11	4608253	4608253	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:4608253G>A	ENST00000312614.4	+	1	233	c.211G>A	c.(211-213)Gga>Aga	p.G71R		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCCCTGTTAGGAAACACCAT	0.502000													21	204					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55944921	55944921	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr10:55944921C>T	ENST00000373965.2	-	13	1828	c.1434G>A	c.(1432-1434)agG>agA	p.R478R	PCDH15_ENST00000409834.1_Silent_p.R82R|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395445.1_Silent_p.R478R|PCDH15_ENST00000395432.2_Silent_p.R434R|PCDH15_ENST00000414778.1_Silent_p.R476R|PCDH15_ENST00000395446.1_Silent_p.R471R|PCDH15_ENST00000395430.1_Silent_p.R471R|PCDH15_ENST00000361849.3_Silent_p.R471R|PCDH15_ENST00000395433.1_Silent_p.R449R|PCDH15_ENST00000373957.3_Silent_p.R449R|PCDH15_ENST00000373955.1_Silent_p.R471R|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000437009.1_Silent_p.R471R|PCDH15_ENST00000395438.1_Silent_p.R471R|PCDH15_ENST00000320301.6_Silent_p.R471R	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	471	Cadherin 4.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GCTGTTCTTCCCTGTCCACTG	0.398000										HNSCC(58;0.16)			79	13					0	0	1	0	0
CCDC11	220136	broad.mit.edu	37	18	47777871	47777871	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr18:47777871C>T	ENST00000398545.4	-	4	874	c.757G>A	c.(757-759)Gaa>Aaa	p.E253K		NM_145020.3	NP_659457.2	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	253										endometrium(1)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|pancreas(1)|skin(1)	20				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		GCCTCCTCTTCCTTCAGCAGC	0.537000													45	70					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157497529	157497529	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:157497529G>A	ENST00000361835.3	-	9	1995	c.1838C>T	c.(1837-1839)cCc>cTc	p.P613L	FCRL5_ENST00000356953.4_Missense_Mutation_p.P613L|FCRL5_ENST00000368190.3_Missense_Mutation_p.P613L|FCRL5_ENST00000368191.3_Missense_Mutation_p.P528L	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	613	Ig-like C2-type 6.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TCCTCCAGAGGGGGCTGAGCT	0.562000													69	102					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20296501	20296501	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:20296501G>A	ENST00000315947.1	+	1	894	c.894G>A	c.(892-894)atG>atA	p.M298I	OR4N2_ENST00000568211.1_3'UTR	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AAGCTTCCATGAAAAAGGTGT	0.353000													20	148					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29610484	29610484	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:29610484G>A	ENST00000373779.3	+	13	2304	c.2175G>A	c.(2173-2175)agG>agA	p.R725R	PTPRU_ENST00000428026.2_Silent_p.R725R|PTPRU_ENST00000415600.2_3'UTR|PTPRU_ENST00000345512.3_Silent_p.R725R|PTPRU_ENST00000323874.8_Silent_p.R725R|PTPRU_ENST00000356870.3_Silent_p.R725R|PTPRU_ENST00000460170.2_Silent_p.R725R	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	725					canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GCATTGCCAGGAAAGGTAAGT	0.622000													84	109					0	0	1	0	0
FAM86EP	348926	broad.mit.edu	37	4	3954857	3954857	+	RNA	SNP	C	C	A	rs17410899		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr4:3954857C>A	ENST00000281228.8	-	0	141				FAM86EP_ENST00000313946.8_RNA																							AATATCCCGCCGCAGCTCAGA	0.488000													3	41					0.000602214	0.000606975	1	1	0
ATP1A2	477	broad.mit.edu	37	1	160104995	160104995	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:160104995C>T	ENST00000361216.3	+	15	2114	c.2025C>T	c.(2023-2025)ctC>ctT	p.L675L	ATP1A2_ENST00000472488.1_3'UTR|ATP1A2_ENST00000392233.3_Silent_p.L675L	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	675					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CGGAGCAGCTCGATGAGATCC	0.577000													34	54					0	0	1	0	0
SLC1A5	6510	broad.mit.edu	37	19	47285799	47285799	+	Missense_Mutation	SNP	A	A	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:47285799A>T	ENST00000542575.2	-	4	1293	c.665T>A	c.(664-666)gTg>gAg	p.V222E	SLC1A5_ENST00000434726.2_Missense_Mutation_p.V20E|SLC1A5_ENST00000594991.1_Missense_Mutation_p.V46E|SLC1A5_ENST00000412532.2_5'UTR	NM_005628.2	NP_005619.1	Q15758	AAAT_HUMAN	solute carrier family 1 (neutral amino acid transporter), member 5	222					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(2)|stomach(1)	13		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	CTCCTGCCCCACGGGCACCTG	0.617000													51	61					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	95947821	95947821	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr9:95947821G>A	ENST00000297954.4	+	1	610	c.610G>A	c.(610-612)Ggt>Agt	p.G204S	WNK2_ENST00000395477.2_Missense_Mutation_p.G204S|WNK2_ENST00000349097.3_5'UTR|WNK2_ENST00000427277.2_5'UTR|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000395475.2_Missense_Mutation_p.G190S			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	204	Protein kinase.				intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						GCTGGGCCGCGGTTCCTTCAA	0.667000													29	7					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497486	1497486	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr8:1497486C>T	ENST00000421627.2	+	2	761	c.627C>T	c.(625-627)ccC>ccT	p.P209P		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	288					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		AGGGCAAGCCCCGGCCCGGCA	0.701000													27	7					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103230239	103230239	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:103230239C>T	ENST00000424685.2	-	28	4108	c.3949G>A	c.(3949-3951)Gct>Act	p.A1317T	RELN_ENST00000343529.5_Missense_Mutation_p.A1317T|RELN_ENST00000428762.1_Missense_Mutation_p.A1317T			P78509	RELN_HUMAN	reelin	1317					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGAACTGGAGCAGTACTGCTG	0.418000													21	106					0	0	1	0	0
OR5M3	219482	broad.mit.edu	37	11	56237200	56237200	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:56237200G>A	ENST00000312240.2	-	1	814	c.774C>T	c.(772-774)ctC>ctT	p.L258L		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	258					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					TGGGACGTCTGAGATACATGA	0.493000													27	27					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57529147	57529147	+	Missense_Mutation	SNP	A	A	G			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:57529147A>G	ENST00000420713.1	+	4	1092	c.980A>G	c.(979-981)gAa>gGa	p.E327G		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						TACAAATGTGAAGAATGTGGC	0.418000													37	39					0	0	1	0	0
ALG11	440138	broad.mit.edu	37	13	52598334	52598334	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr13:52598334C>T	ENST00000521508.1	+	3	473	c.468C>T	c.(466-468)tcC>tcT	p.S156S	ALG11_ENST00000523764.1_Intron|ALG11_ENST00000519151.1_3'UTR	NM_001004127.2	NP_001004127.2			ALG11, alpha-1,2-mannosyltransferase											endometrium(1)|large_intestine(6)|lung(4)|ovary(2)	13		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.44e-08)		GTCTAGGATCCATTTTTCTTG	0.413000													63	97					0	0	1	0	0
OR52I1	390037	broad.mit.edu	37	11	4615401	4615401	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:4615401G>A	ENST00000450052.2	+	2	205	c.205G>A	c.(205-207)Gga>Aga	p.G69R	OR52I1_ENST00000530443.2_Missense_Mutation_p.G45R			Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I, member 1	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	15		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCCCTGTTAGGAAACACCCT	0.512000													75	95					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77763832	77763832	+	Missense_Mutation	SNP	C	C	G			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr8:77763832C>G	ENST00000521891.2	+	10	5123	c.4675C>G	c.(4675-4677)Cac>Gac	p.H1559D	ZFHX4_ENST00000518282.1_Missense_Mutation_p.H1533D|ZFHX4_ENST00000050961.6_Missense_Mutation_p.H1514D|ZFHX4_ENST00000455469.2_Missense_Mutation_p.H1514D	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1514						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCTCTTGGTCCACTATAATTC	0.403000										HNSCC(33;0.089)			24	28					0	0	1	0	0
PHACTR4	65979	broad.mit.edu	37	1	28818191	28818191	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:28818191C>T	ENST00000373839.3	+	12	2169	c.1908C>T	c.(1906-1908)ctC>ctT	p.L636L	PHACTR4_ENST00000373836.3_Silent_p.L646L|PHACTR4_ENST00000493669.1_3'UTR	NM_001048183.1	NP_001041648.1	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4	636							actin binding|protein phosphatase inhibitor activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TCGCTGAACTCCTTGCCAGGA	0.463000													59	67					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138451538	138451538	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr4:138451538C>T	ENST00000344876.4	-	1	2091	c.1705G>A	c.(1705-1707)Gaa>Aaa	p.E569K	PCDH18_ENST00000412923.2_Missense_Mutation_p.E569K|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000507846.1_Missense_Mutation_p.E349K|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	569	Cadherin 5.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TTGTCATTTTCGTCAATGATG	0.458000													115	153					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037960	75037960	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:75037960C>T	ENST00000326665.5	-	14	3652	c.3434G>A	c.(3433-3435)gGa>gAa	p.G1145E	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1145	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TGAATCTTCTCCTAGAAGCCC	0.463000													57	64					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52283781	52283781	+	Silent	SNP	G	G	A	rs139339992		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:52283781G>A	ENST00000354831.7	-	12	1711	c.1522C>T	c.(1522-1524)Ctg>Ttg	p.L508L	NRD1_ENST00000485608.1_5'UTR|NRD1_ENST00000352171.7_Silent_p.L440L|NRD1_ENST00000544028.1_Silent_p.L308L|NRD1_ENST00000539524.1_Silent_p.L376L	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	439					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						GTGATGGTCAGAGCATGAATT	0.323000													18	20					0	0	1	0	0
MORC2	22880	broad.mit.edu	37	22	31345759	31345759	+	Missense_Mutation	SNP	T	T	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr22:31345759T>A	ENST00000215862.4	-	6	1473	c.110A>T	c.(109-111)cAg>cTg	p.Q37L	MORC2_ENST00000397641.2_Missense_Mutation_p.Q99L	NM_014941.1	NP_055756.1	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	99							ATP binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	21						ATTCCCGTACTGCCCAATCTG	0.463000													62	125					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	970681	970681	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:970681C>T	ENST00000379370.2	+	3	538	c.488C>T	c.(487-489)cCa>cTa	p.P163L	AGRN_ENST00000477585.1_3'UTR	NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	163					axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CACTTCACTCCAGTGCCTCCG	0.597000													63	133					0	0	1	0	0
ARID3B	10620	broad.mit.edu	37	15	74883672	74883672	+	Silent	SNP	T	T	C			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:74883672T>C	ENST00000346246.5	+	6	1293	c.1062T>C	c.(1060-1062)ctT>ctC	p.L354L		NM_006465.2	NP_006456.1	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B (BRIGHT-like)	354	Interaction with RB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.L354L(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(2)	14						CCCCTGCCCTTCTCTCCCCAC	0.647000													4	165					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55944920	55944920	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr10:55944920C>T	ENST00000373965.2	-	13	1829	c.1435G>A	c.(1435-1437)Gaa>Aaa	p.E479K	PCDH15_ENST00000409834.1_Missense_Mutation_p.E83K|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395445.1_Missense_Mutation_p.E479K|PCDH15_ENST00000395432.2_Missense_Mutation_p.E435K|PCDH15_ENST00000414778.1_Missense_Mutation_p.E477K|PCDH15_ENST00000395446.1_Missense_Mutation_p.E472K|PCDH15_ENST00000395430.1_Missense_Mutation_p.E472K|PCDH15_ENST00000361849.3_Missense_Mutation_p.E472K|PCDH15_ENST00000395433.1_Missense_Mutation_p.E450K|PCDH15_ENST00000373957.3_Missense_Mutation_p.E450K|PCDH15_ENST00000373955.1_Missense_Mutation_p.E472K|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.E472K|PCDH15_ENST00000395438.1_Missense_Mutation_p.E472K|PCDH15_ENST00000320301.6_Missense_Mutation_p.E472K	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	472	Cadherin 4.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGCTGTTCTTCCCTGTCCACT	0.403000										HNSCC(58;0.16)			80	13					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104730540	104730540	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:104730540C>T	ENST00000334877.4	+	14	1977	c.1443C>T	c.(1441-1443)atC>atT	p.I481I	KMT2E_ENST00000257745.4_Silent_p.I481I|KMT2E_ENST00000476671.1_Silent_p.I481I|KMT2E_ENST00000334914.7_5'UTR|KMT2E_ENST00000311117.3_Silent_p.I481I					lysine (K)-specific methyltransferase 2E																		TGGAAAATATCAATAGTGGTT	0.358000													88	184					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123886708	123886708	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr11:123886708C>T	ENST00000320891.4	+	1	427	c.427C>T	c.(427-429)Ctg>Ttg	p.L143L		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTGTGCCCTCCTGGCCACCGG	0.547000													13	289					0	0	1	0	0
IFNA10	3446	broad.mit.edu	37	9	21206918	21206918	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr9:21206918C>T	ENST00000357374.2	-	1	224	c.179G>A	c.(178-180)cGa>cAa	p.R60Q		NM_002171.1	NP_002162.1	P01566	IFN10_HUMAN	interferon, alpha 10	60					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|large_intestine(3)|liver(1)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	16				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		CTGGGGGATTCGGAAATCATG	0.517000													5	227					0	0	1	0	0
KRT19P2	160313	broad.mit.edu	37	12	95228418	95228418	+	RNA	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr12:95228418G>A	ENST00000405395.2	+	0	189					NR_036685.1																						GCATGAGGAGGAAATCAATGC	0.557000													17	4					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9024984	9024984	+	Missense_Mutation	SNP	C	C	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:9024984C>A	ENST00000397910.4	-	16	37081	c.36878G>T	c.(36877-36879)gGg>gTg	p.G12293V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12295	SEA 2.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTGGCTGCCCCATCTTTCTC	0.552000													36	58					2.20474e-14	2.30413e-14	1	1	0
TTN	7273	broad.mit.edu	37	2	179481253	179481253	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:179481253C>T	ENST00000589042.1	-	257	48489	c.48265G>A	c.(48265-48267)Gga>Aga	p.G16089R	TTN_ENST00000460472.2_Missense_Mutation_p.G7024R|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G14448R|TTN_ENST00000359218.5_Missense_Mutation_p.G7149R|TTN_ENST00000342992.6_Missense_Mutation_p.G13521R|TTN_ENST00000342175.6_Missense_Mutation_p.G7216R|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14448	Ig-like 99.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAACGTATCCAGTTAACGGA	0.433000													51	165					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518217	113518217	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:113518217G>A	ENST00000284601.3	-	4	2998	c.2930C>T	c.(2929-2931)tCc>tTc	p.S977F		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	977					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TGAACTTCTGGAAACTTCTTC	0.378000													47	125					0	0	1	0	0
DCAF6	55827	broad.mit.edu	37	1	167962652	167962652	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:167962652C>T	ENST00000367840.3	+	7	971	c.877C>T	c.(877-879)Cct>Tct	p.P293S	DCAF6_ENST00000432587.2_Missense_Mutation_p.P262S|DCAF6_ENST00000367843.3_Missense_Mutation_p.P293S|DCAF6_ENST00000312263.6_Missense_Mutation_p.P293S	NM_001198956.1	NP_001185885.1	Q58WW2	DCAF6_HUMAN	DDB1 and CUL4 associated factor 6	293					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	36						ACTTAAAACTCCTTCTGCGGA	0.468000													44	49					0	0	1	0	0
CRIPAK	285464	broad.mit.edu	37	4	1389265	1389265	+	Silent	SNP	T	T	C	rs71299249		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr4:1389265T>C	ENST00000324803.4	+	1	3926	c.966T>C	c.(964-966)gcT>gcC	p.A322A		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	322					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			GCCCGCCTGCTCACACGTGCC	0.672000													4	264					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22942219	22942219	+	Splice_Site	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:22942219C>T	ENST00000397104.3	-	4	554	c.555_splice	c.e4+1	p.K185_splice	ZNF99_ENST00000596209.1_Silent_p.K164K					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGTGTCTAATCTTATATCTAT	0.269000													10	6					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76965171	76965171	+	Missense_Mutation	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:76965171C>T	ENST00000261532.7	+	8	1471	c.1399C>T	c.(1399-1401)Ccc>Tcc	p.P467S	ESRRB_ENST00000509242.1_Intron|ESRRB_ENST00000380887.2_Intron|RP11-187O7.3_ENST00000554926.1_lincRNA			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	0						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		TTTCCTAACTCCCTTGCCCCC	0.632000													14	33					0	0	1	0	0
CYP4F22	126410	broad.mit.edu	37	19	15636311	15636311	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr19:15636311G>A	ENST00000269703.2	+	3	363	c.164G>A	c.(163-165)cGg>cAg	p.R55Q	CYP4F22_ENST00000601005.2_Missense_Mutation_p.R55Q	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	55						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						ACCTGCCGCCGGCTGCGCTGC	0.667000													31	56					0	0	1	0	0
ADRA1B	147	broad.mit.edu	37	5	159344455	159344455	+	Silent	SNP	C	C	T			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:159344455C>T	ENST00000306675.3	+	1	666	c.543C>T	c.(541-543)ctC>ctT	p.L181L		NM_000679.3	NP_000670.1	P35368	ADA1B_HUMAN	adrenoceptor alpha 1B	181					cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	TCGGGCCTCTCCTTGGGTGGA	0.602000													37	42					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169938347	169938347	+	Missense_Mutation	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:169938347G>A	ENST00000327239.4	+	5	1760	c.256G>A	c.(256-258)Gac>Aac	p.D86N	DHRS9_ENST00000602501.1_Missense_Mutation_p.D86N|DHRS9_ENST00000436483.2_Missense_Mutation_p.D86N|DHRS9_ENST00000432060.2_Missense_Mutation_p.D146N|DHRS9_ENST00000428522.1_Missense_Mutation_p.D86N|DHRS9_ENST00000357546.2_Missense_Mutation_p.D86N|DHRS9_ENST00000412271.1_Missense_Mutation_p.D86N|DHRS9_ENST00000421653.1_5'UTR	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	86					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						GGATGTGACCGACCCAGAGAA	0.507000													59	37					0	0	1	0	0
SMARCC2	6601	broad.mit.edu	37	12	56572812	56572812	+	Silent	SNP	G	G	A			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr12:56572812G>A	ENST00000394023.3	-	12	1215	c.1110C>T	c.(1108-1110)gcC>gcT	p.A370A	SMARCC2_ENST00000267064.4_Silent_p.A370A|SMARCC2_ENST00000550164.1_Silent_p.A370A|SMARCC2_ENST00000347471.4_Silent_p.A370A|RP11-977G19.5_ENST00000553176.1_RNA	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	370					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			CTTTGACTGGGGCCGACTCTG	0.512000													63	18					0	0	1	0	0
SRGAP2B	647135	broad.mit.edu	37	1	144015779	144015780	+	RNA	DEL	AC	AC	-	rs57828590		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:144015779_144015780delAC	ENST00000467933.1	+	0	1108																											ctccagtcctactataacaaga	0.406													3	5	---	---	---	---					
RORC	6097	broad.mit.edu	37	1	151780064	151780064	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:151780064delC	ENST00000356728.6	-	10	1532	c.1378delG	c.(1378-1380)aafs	p.E460fs	RORC_ENST00000480719.1_5'UTR|RORC_ENST00000318247.6_Frame_Shift_Del_p.E481fs|RORC_ENST00000392697.3_Frame_Shift_Del_p.E535fs	NM_001001523.1	NP_001001523.1	P51449	RORG_HUMAN	RAR-related orphan receptor C	481	Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGCAGCCTTTCCACATGCTGG	0.562													38	41	---	---	---	---					
LINC01341	149134	broad.mit.edu	37	1	246953503	246953503	+	RNA	DEL	A	A	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:246953503delA	ENST00000421003.1	+	0	1521																											CCAAATGGGGAGCGGCCAATC	0.637													2	4	---	---	---	---					
RP11-634B7.4	0	broad.mit.edu	37	1	247903035	247903036	+	RNA	INS	-	-	T	rs35382545		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr1:247903035_247903036insT	ENST00000449298.1	+	0	681																											AATTTTTGCACttttttttttt	0.381													3	4	---	---	---	---					
LINC01248	102723818	broad.mit.edu	37	2	5802461	5802461	+	RNA	DEL	A	A	-	rs35679220		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:5802461delA	ENST00000453678.1	-	0	258				AC107057.2_ENST00000458264.1_RNA																							ttgtaaaaagaaaaaaaaaat	0.358													3	3	---	---	---	---					
RAB6C-AS1	100131320	broad.mit.edu	37	2	130726035	130726035	+	RNA	DEL	A	A	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:130726035delA	ENST00000412425.1	-	0	667					NR_036537.1																						attgttttttaaaatgtatac	0.284													7	21	---	---	---	---					
LOC101927156	101927156	broad.mit.edu	37	2	182009751	182009752	+	RNA	INS	-	-	C			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:182009751_182009752insC	ENST00000435411.1	+	0	144																											tccctccggtggggtttgttgt	0.525													2	4	---	---	---	---					
AC067956.1	0	broad.mit.edu	37	2	221428377	221428377	+	RNA	DEL	A	A	-	rs77718795		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr2:221428377delA	ENST00000414512.1	+	0	368																											actctgtctcaaaaaaaaaaa	0.463													2	4	---	---	---	---					
AC136289.1	0	broad.mit.edu	37	3	63790093	63790093	+	RNA	DEL	T	T	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr3:63790093delT	ENST00000443346.1	-	0	622																											tcccacgtgctttctctttgg	0.483													2	4	---	---	---	---					
RP11-269F21.3	0	broad.mit.edu	37	4	112914146	112914146	+	RNA	DEL	A	A	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr4:112914146delA	ENST00000511219.1	-	0	134																											AAACTTTGGCAAGACCCAGGG	0.418													2	4	---	---	---	---					
LOC285692	285692	broad.mit.edu	37	5	9795607	9795607	+	RNA	DEL	A	A	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:9795607delA	ENST00000511616.1	-	0	521					NR_027112.2																						TACCTCCAAGAAAAAAAAAAG	0.443													2	4	---	---	---	---					
CTB-43E15.2	0	broad.mit.edu	37	5	173125983	173125984	+	RNA	DEL	CA	CA	-	rs71879960		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr5:173125983_173125984delCA	ENST00000521373.1	+	0	95																											ATGGGGCGGCcacacacacaca	0.540													2	4	---	---	---	---					
RP1-223B1.1	0	broad.mit.edu	37	6	3606705	3606706	+	RNA	INS	-	-	ACACACACAT	rs72508000		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr6:3606705_3606706insACACACACAT	ENST00000443445.1	-	0	500																											cacacagacacacacacacaca	0.574													5	3	---	---	---	---					
LY86-AS1	285780	broad.mit.edu	37	6	6453860	6453862	+	RNA	DEL	TTT	TTT	-	rs80329653		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr6:6453860_6453862delTTT	ENST00000435641.1	-	0	482				LY86-AS1_ENST00000447858.1_RNA|LY86-AS1_ENST00000429345.1_RNA																							ctgatgtcaattttttttatcta	0.365													4	2	---	---	---	---					
LINC00243	401247	broad.mit.edu	37	6	30791099	30791100	+	RNA	INS	-	-	A	rs11312241		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr6:30791099_30791100insA	ENST00000399196.1	-	0	145																											gactccatctcaaaaaaaaaaa	0.455													3	3	---	---	---	---					
LOC101927769	101927769	broad.mit.edu	37	7	20339383	20339384	+	RNA	DEL	CA	CA	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:20339383_20339384delCA	ENST00000446399.1	+	0	168																											ttaaaaaattcacacacacaca	0.475													4	4	---	---	---	---					
DPY19L2P1	554236	broad.mit.edu	37	7	35145789	35145793	+	RNA	DEL	CTAAA	CTAAA	-	rs76141590		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:35145789_35145793delCTAAA	ENST00000436258.1	-	0	1553_1557																											GTGACTATCTCTAAACTACTTAGGA	0.190													4	6	---	---	---	---					
RP11-368M16.3	0	broad.mit.edu	37	7	57701099	57701099	+	RNA	DEL	T	T	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:57701099delT	ENST00000605139.1	-	0	416																											ctggccCAAGTTTTTTTCTAT	0.522													3	6	---	---	---	---					
RP5-945F2.3	0	broad.mit.edu	37	7	67629572	67629573	+	RNA	DEL	TC	TC	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr7:67629572_67629573delTC	ENST00000446187.1	-	0	444																											CAGTTCTTATTCTCTCTCTCTC	0.490													2	4	---	---	---	---					
UBXN8	7993	broad.mit.edu	37	8	30612473	30612474	+	RNA	INS	-	-	T	rs34741520		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr8:30612473_30612474insT	ENST00000519246.1	+	0	604							O00124	UBXN8_HUMAN	UBX domain protein 8						single fertilization					central_nervous_system(1)|lung(2)	3						GGGGTTGGTCGttttttttttt	0.391													3	3	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130540135	130540135	+	RNA	DEL	A	A	-	rs79905354		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr8:130540135delA	ENST00000446592.3	-	0	312																											actccatctcaaaaaaaaaaa	0.413													2	4	---	---	---	---					
LOC100132077	100132077	broad.mit.edu	37	9	97097144	97097144	+	RNA	DEL	T	T	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr9:97097144delT	ENST00000454869.1	+	0	513					NR_033937.1																						CAAGTTATAAttttttttttt	0.498													2	4	---	---	---	---					
CEL	1056	broad.mit.edu	37	9	135947051	135947052	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr9:135947051_135947052insC	ENST00000372080.4	+	11	2187_2188	c.2171_2172insC	c.(2170-2172)ggcfs	p.G724fs	CEL_ENST00000351304.7_Frame_Shift_Ins_p.G655fs	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	721	17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type).				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		GGTGACTCCGGGGCCCCCCCTG	0.728													9	3	---	---	---	---					
LINC01573	101928483	broad.mit.edu	37	9	139440926	139440926	+	RNA	DEL	G	G	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr9:139440926delG	ENST00000429224.1	+	0	160																											AGGCCACGTTGGGGGACCCCG	0.761													2	4	---	---	---	---					
LINC00842	643650	broad.mit.edu	37	10	47109460	47109461	+	RNA	INS	-	-	G	rs67033757	by1000genomes	TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr10:47109460_47109461insG	ENST00000422732.2	-	0	435					NR_033957.1																						caTCCTCCCCCCCCATCATGCT	0.530													3	6	---	---	---	---					
TMEM26-AS1	101928781	broad.mit.edu	37	10	63226729	63226730	+	RNA	DEL	GT	GT	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr10:63226729_63226730delGT	ENST00000389640.4	+	0	651																											ACAGTGTCTGgtgtgtgtgtgt	0.391													2	4	---	---	---	---					
CTAGE5	4253	broad.mit.edu	37	14	39746242	39746243	+	Frame_Shift_Ins	INS	-	-	T	rs75842899	byFrequency	TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:39746242_39746243insT	ENST00000553728.1	+	6	1986_1987	c.1773_1774insT	c.(1771-1776)ctttttfs	p.LF591fs	CTAGE5_ENST00000396158.2_Frame_Shift_Ins_p.LF56fs|CTAGE5_ENST00000557038.1_5'UTR|CTAGE5_ENST00000556148.1_Intron|RP11-407N17.3_ENST00000603904.1_Frame_Shift_Ins_p.LF27fs|CTAGE5_ENST00000396165.4_Frame_Shift_Ins_p.LF27fs|CTAGE5_ENST00000341749.3_Frame_Shift_Ins_p.LF44fs|CTAGE5_ENST00000341502.5_Frame_Shift_Ins_p.LF56fs|CTAGE5_ENST00000280083.3_Frame_Shift_Ins_p.LF56fs|CTAGE5_ENST00000348007.3_Frame_Shift_Ins_p.LF56fs|CTAGE5_ENST00000553352.1_Frame_Shift_Ins_p.LF27fs																							TTGCTGTTCTCTTTTTTTTGTG	0.371													7	185	---	---	---	---					
RP11-187O7.3	0	broad.mit.edu	37	14	77118202	77118202	+	RNA	DEL	C	C	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:77118202delC	ENST00000554926.1	-	0	194																											atctccctttccacaagtttt	0.552											OREG0031334	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	2	4	---	---	---	---					
IRF2BPL	64207	broad.mit.edu	37	14	77493792	77493794	+	In_Frame_Del	DEL	TGT	TGT	-	rs28718623		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:77493792_77493794delTGT	ENST00000238647.3	-	1	1240_1242	c.342_344delACA	c.(340-345)cag>ca	p.QQ126del		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	126	Poly-Gln.					nucleus				endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						ctgctgctgctgttgctgctgct	0.700													4	9	---	---	---	---					
RP11-526N18.1	0	broad.mit.edu	37	14	80425285	80425286	+	RNA	INS	-	-	A	rs142819658	by1000genomes	TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr14:80425285_80425286insA	ENST00000554307.1	-	0	366																											acaaacaaatgaaaaaaagctc	0.347													3	3	---	---	---	---					
GOLGA6L2	283685	broad.mit.edu	37	15	23685037	23685038	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr15:23685037_23685038insC	ENST00000567107.1	-	8	2636_2637	c.2584_2585insG	c.(2584-2586)aggfs	p.R862fs	GOLGA6L2_ENST00000345070.5_Intron|GOLGA6L2_ENST00000312015.5_Intron					golgin A6 family-like 2											breast(1)|endometrium(7)	8						ttctcctcctgcccccacatct	0.594													2	4	---	---	---	---					
RP11-445F12.1	0	broad.mit.edu	37	17	35274568	35274569	+	RNA	INS	-	-	CA	rs35864103	by1000genomes	TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr17:35274568_35274569insCA	ENST00000532387.2	-	0	95				RP11-445F12.1_ENST00000528383.1_RNA|RP11-445F12.1_ENST00000529264.1_RNA																							acacatgcacgcacacacacac	0.559													2	4	---	---	---	---					
TNRC6C	57690	broad.mit.edu	37	17	76046980	76046980	+	Frame_Shift_Del	DEL	A	A	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr17:76046980delA	ENST00000335749.4	+	3	2406	c.1837delA	c.(1837-1839)aafs	p.K614fs	TNRC6C_ENST00000544502.1_Frame_Shift_Del_p.K614fs|TNRC6C_ENST00000541771.1_Frame_Shift_Del_p.K614fs|TNRC6C_ENST00000588847.1_Frame_Shift_Del_p.K614fs|TNRC6C_ENST00000588061.1_Frame_Shift_Del_p.K614fs|TNRC6C_ENST00000301624.4_Frame_Shift_Del_p.K614fs	NM_001142640.1	NP_001136112.1	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C	614	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GGGGGATGGGAAAAAAAATGG	0.522													7	237	---	---	---	---					
LOC101929650	101929650	broad.mit.edu	37	17	81102172	81102172	+	RNA	DEL	G	G	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr17:81102172delG	ENST00000572343.1	+	0	522																											TGTGTGGGGTGGGAAGGGGCC	0.627													2	4	---	---	---	---					
RP11-103J8.1	0	broad.mit.edu	37	20	10773019	10773019	+	RNA	DEL	A	A	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr20:10773019delA	ENST00000605292.1	+	0	98																											CTTTTACTGTAAGGGAGTTGC	0.378													2	4	---	---	---	---					
LOC101929486	101929486	broad.mit.edu	37	20	12855127	12855132	+	RNA	DEL	TGTATA	TGTATA	-	rs139454824	by1000genomes	TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr20:12855127_12855132delTGTATA	ENST00000456265.1	-	0	2455																											cgtgtgtgtgtgtatatatatatata	0.345													3	3	---	---	---	---					
ZHX3	23051	broad.mit.edu	37	20	39832962	39832962	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr20:39832962delT	ENST00000309060.3	-	4	1010	c.595delA	c.(595-597)ttfs	p.I199fs	ZHX3_ENST00000560361.1_Frame_Shift_Del_p.I199fs|ZHX3_ENST00000559234.1_Frame_Shift_Del_p.I199fs|ZHX3_ENST00000432768.2_Frame_Shift_Del_p.I199fs|ZHX3_ENST00000558993.1_Frame_Shift_Del_p.I199fs|ZHX3_ENST00000557816.1_Frame_Shift_Del_p.I199fs|ZHX3_ENST00000544979.2_Frame_Shift_Del_p.I199fs|ZHX3_ENST00000540170.1_Frame_Shift_Del_p.I199fs			Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	199					negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(5)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		Myeloproliferative disorder(115;0.00425)				AGTGTATGAATTTTTTTGGCT	0.488													8	240	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11089271	11089273	+	RNA	DEL	CAC	CAC	-	rs150553952		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr21:11089271_11089273delCAC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gtaatcccaacactttggaaggc	0.433													4	5	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11091170	11091171	+	RNA	INS	-	-	T	rs112568653		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr21:11091170_11091171insT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		aaaataaaaTATTTTTTAAAAA	0.351													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11093095	11093095	+	RNA	DEL	A	A	-	rs145159759		TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chr21:11093095delA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTTACCATGCAAAAAAATATA	0.403													6	9	---	---	---	---					
TXLNGY	246126	broad.mit.edu	37	Y	21758039	21758039	+	RNA	DEL	A	A	-			TCGA-GF-A769-01A-32D-A32N-08	TCGA-GF-A769-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca94d3c4-41ff-418c-86cb-309837e826ec	4730cc29-5448-4d92-b35e-406eb9dadf74	g.chrY:21758039delA	ENST00000253320.4	+	0	3120							Q9BZA5	CY15A_HUMAN												haematopoietic_and_lymphoid_tissue(1)	1						TACTTCTTGGAAAAAAAAAAA	0.378													4	7	---	---	---	---