Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIF1A	547	broad.mit.edu	37	2	241657548	241657548	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:241657548C>T	ENST00000498729.2	-	48	5498	c.5252G>A	c.(5251-5253)gGc>gAc	p.G1751D	KIF1A_ENST00000320389.7_Missense_Mutation_p.G1650D	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	1650					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CAGCAGGATGCCGCGGTGTTC	0.667000													7	14					0	0	0.001984	0	0
TCTN3	26123	broad.mit.edu	37	10	97446807	97446807	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:97446807G>A	ENST00000265993.8	-	6	1089	c.846C>T	c.(844-846)gtC>gtT	p.V282V	TCTN3_ENST00000371209.5_Silent_p.V282V|TCTN3_ENST00000371217.4_Silent_p.V300V|TCTN3_ENST00000430368.1_Silent_p.V203V	NM_015631.5	NP_056446.4	Q6NUS6	TECT3_HUMAN	tectonic family member 3	282					apoptosis	integral to membrane				breast(3)|endometrium(1)|large_intestine(2)|lung(8)|urinary_tract(1)	15		Colorectal(252;0.0815)		Epithelial(162;1.69e-07)|all cancers(201;5.63e-06)		CTACCTTTAAGACTGTGAAGT	0.418000													26	33					0	0	0.001061	0	0
NFATC1	4772	broad.mit.edu	37	18	77170938	77170938	+	Silent	SNP	T	T	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr18:77170938T>C	ENST00000253506.5	+	2	1032	c.663T>C	c.(661-663)ttT>ttC	p.F221F	NFATC1_ENST00000586434.1_Silent_p.F208F|NFATC1_ENST00000545796.1_Intron|NFATC1_ENST00000542384.1_Silent_p.F221F|NFATC1_ENST00000587635.1_Silent_p.F221F|NFATC1_ENST00000592223.1_Silent_p.F208F|NFATC1_ENST00000318065.5_Silent_p.F208F|NFATC1_ENST00000329101.4_Silent_p.F208F|NFATC1_ENST00000397790.2_Intron|NFATC1_ENST00000591814.1_Silent_p.F221F|NFATC1_ENST00000427363.2_Silent_p.F221F	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	221	3 X SP repeats.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		AGGAGGGCTTTCCCCGCGGGC	0.706000													56	48					0	0	0.003610	0	0
IRF6	3664	broad.mit.edu	37	1	209961987	209961987	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:209961987G>A	ENST00000367021.3	-	9	1354	c.1182C>T	c.(1180-1182)gtC>gtT	p.V394V	IRF6_ENST00000542854.1_Silent_p.V299V	NM_006147.3	NP_006138.1	O14896	IRF6_HUMAN	interferon regulatory factor 6	394					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	28				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		CTACTGGAATGACCTGTTCAG	0.473000										HNSCC(57;0.16)			30	26					0	0	0.001951	0	0
PRMT10	90826	broad.mit.edu	37	4	148601580	148601580	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:148601580C>T	ENST00000322396.6	-	2	474	c.232G>A	c.(232-234)Gat>Aat	p.D78N	PRMT10_ENST00000541232.1_Intron	NM_138364.2	NP_612373.2	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10 (putative)	78						cytoplasm	binding|protein methyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28						CTGAGAGCATCAAGCTCTTCA	0.363000													15	33					0	0	0.004007	0	0
EPOR	2057	broad.mit.edu	37	19	11489124	11489124	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:11489124G>A	ENST00000222139.6	-	8	1167	c.1063C>T	c.(1063-1065)Ctg>Ttg	p.L355L	EPOR_ENST00000592375.2_3'UTR	NM_000121.3	NP_000112.1	P19235	EPOR_HUMAN	erythropoietin receptor	355						extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	GGCTCCAGCAGGGGGCCCTCA	0.657000											OREG0025254	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	48					0	0	0.001786	0	0
ZAN	7455	broad.mit.edu	37	7	100390093	100390093	+	RNA	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:100390093C>T	ENST00000542585.1	+	0	7924				ZAN_ENST00000443370.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GTTGCCAGGTCCTCAGTGGGT	0.672000													41	44					0	0	0.001706	0	0
CASS4	57091	broad.mit.edu	37	20	55028076	55028076	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:55028076C>T	ENST00000371336.3	+	5	2045	c.1844C>T	c.(1843-1845)cCc>cTc	p.P615L	CASS4_ENST00000360314.3_Missense_Mutation_p.P615L|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	615					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						ATCCAGCCTCCCCAAAGAGAA	0.413000													17	33					0	0	0.004990	0	0
ZDHHC6	64429	broad.mit.edu	37	10	114192019	114192019	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:114192019G>A	ENST00000369405.3	-	10	1540	c.1117C>T	c.(1117-1119)Ctt>Ttt	p.L373F	ZDHHC6_ENST00000369404.3_Missense_Mutation_p.L369F|ZDHHC6_ENST00000482410.1_5'UTR	NM_022494.1	NP_071939.1	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	373						integral to membrane	acyltransferase activity|zinc ion binding	p.L373I(1)		endometrium(4)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		GAATCATCAAGAATTTTGTCT	0.269000													13	28					0	0	0.003163	0	0
ACTRT3	84517	broad.mit.edu	37	3	169485798	169485798	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:169485798C>T	ENST00000330368.2	-	2	915	c.541G>A	c.(541-543)Ggc>Agc	p.G181S		NM_032487.4	NP_115876.3	Q9BYD9	ARPM1_HUMAN	actin-related protein T3	181						cytoplasm|cytoskeleton											AGGTCAAGGCCTGCCAGATCC	0.498000													30	47					0	0	0.001512	0	0
FAM169A	26049	broad.mit.edu	37	5	74078953	74078953	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:74078953C>T	ENST00000389156.4	-	12	1357	c.1267G>A	c.(1267-1269)Gaa>Aaa	p.E423K	FAM169A_ENST00000510496.1_Missense_Mutation_p.E363K|FAM169A_ENST00000380515.3_3'UTR	NM_015566.2	NP_056381.1	Q9Y6X4	F169A_HUMAN	family with sequence similarity 169, member A	423	Asp/Glu-rich.									breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	27						GGCTCTAATTCAGATTCCTAC	0.398000													45	27					0	0	0.003610	0	0
VN1R4	317703	broad.mit.edu	37	19	53770596	53770596	+	Missense_Mutation	SNP	G	G	A	rs74977010		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:53770596G>A	ENST00000311170.4	-	1	376	c.323C>T	c.(322-324)aCg>aTg	p.T108M		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	108					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		GGAGCTGACCGTGATCACCTG	0.507000										HNSCC(26;0.072)			16	45					0	0	0.004007	0	0
CABYR	26256	broad.mit.edu	37	18	21735699	21735699	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr18:21735699G>A	ENST00000399496.3	+	4	399	c.234G>A	c.(232-234)aaG>aaA	p.K78K	CABYR_ENST00000399499.1_Silent_p.K78K|CABYR_ENST00000327201.6_5'UTR|CABYR_ENST00000581397.1_Silent_p.K78K|CABYR_ENST00000399481.2_5'UTR|CABYR_ENST00000415309.2_Silent_p.K78K	NM_012189.2|NM_153769.1	NP_036321.2|NP_722453.1	O75952	CABYR_HUMAN	calcium binding tyrosine-(Y)-phosphorylation regulated	78					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)	11	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					CACCACAGAAGAAATTAGAAT	0.338000													36	57					0	0	0.001287	0	0
SLC41A3	54946	broad.mit.edu	37	3	125725967	125725967	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:125725967C>T	ENST00000383598.2	-	10	1563	c.1278G>A	c.(1276-1278)ggG>ggA	p.G426G	SLC41A3_ENST00000360370.4_Silent_p.G452G|SLC41A3_ENST00000315891.6_Silent_p.G452G|SLC41A3_ENST00000346785.5_Silent_p.G416G|SLC41A3_ENST00000508835.1_Silent_p.G335G	NM_001008487.1	NP_001008487.1	Q96GZ6	S41A3_HUMAN	solute carrier family 41, member 3	452						integral to membrane|plasma membrane	cation transmembrane transporter activity			breast(1)|endometrium(4)|large_intestine(6)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18				GBM - Glioblastoma multiforme(114;0.167)		CGAGCAGGTCCCCCAGCCCTG	0.577000													23	54					0	0	0.002299	0	0
EEF1B2	1933	broad.mit.edu	37	2	207024727	207024727	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:207024727C>T	ENST00000392222.2	+	1	399	c.24C>T	c.(22-24)agC>agT	p.S8S	EEF1B2_ENST00000236957.5_Silent_p.S8S|EEF1B2_ENST00000392221.1_Silent_p.S8S	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	8	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						ACCTGAAAAGCCCTGCCGGCC	0.632000													18	92					0	0	0.001216	0	0
ZNF71	58491	broad.mit.edu	37	19	57133976	57133976	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:57133976G>A	ENST00000328070.6	+	3	1555	c.1321G>A	c.(1321-1323)Ggc>Agc	p.G441S		NM_021216.4	NP_067039.1	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	441						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GTACAGGTGCGGCCAGTGCGG	0.647000													13	33					0	0	0.001368	0	0
KAT2B	8850	broad.mit.edu	37	3	20136767	20136767	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:20136767C>T	ENST00000263754.4	+	3	898	c.443C>T	c.(442-444)tCc>tTc	p.S148F	KAT2B_ENST00000426228.1_3'UTR	NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	148					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						GCTCATGTTTCCCACCTGGAG	0.403000													9	29					0	0	0.004482	0	0
BRAT1	221927	broad.mit.edu	37	7	2578367	2578367	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:2578367G>A	ENST00000340611.4	-	14	2058	c.1802C>T	c.(1801-1803)tCc>tTc	p.S601F	BRAT1_ENST00000473879.1_5'UTR	NM_152743.3	NP_689956.2	Q6PJG6	BRAT1_HUMAN	BRCA1-associated ATM activator 1	601					response to ionizing radiation	nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23						CGAGTCTACGGAGAGGATGTG	0.672000													38	46					0	0	0.001706	0	0
HNRNPU	3192	broad.mit.edu	37	1	245018278	245018278	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:245018278C>T	ENST00000444376.2	-	13	2598	c.2364G>A	c.(2362-2364)caG>caA	p.Q788Q	HNRNPU_ENST00000283179.9_Silent_p.Q807Q|HNRNPU-AS1_ENST00000475997.1_RNA	NM_004501.3|NM_031844.2	NP_004492.2|NP_114032.2	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	807	Gly-rich.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding			NS(1)|endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			TACTTACACCCTGCTGCCACT	0.373000													10	90					0	0	0.000978	0	0
DKK2	27123	broad.mit.edu	37	4	107845783	107845783	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:107845783G>A	ENST00000285311.3	-	3	1153	c.448C>T	c.(448-450)Cga>Tga	p.R150*	DKK2_ENST00000513208.1_Nonsense_Mutation_p.R50*|DKK2_ENST00000510463.1_Nonsense_Mutation_p.R104*	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	150					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CCGTGGTTTCGATCTCTGTGC	0.448000													29	72					0	0	0.003755	0	0
NRAS	4893	broad.mit.edu	37	1	115256530	115256530	+	Missense_Mutation	SNP	G	G	T	rs121913254		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:115256530G>T	ENST00000369535.4	-	3	434	c.181C>A	c.(181-183)Caa>Aaa	p.Q61K		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61K(595)|p.Q61E(9)|p.Q61L(3)|p.Q61R(2)|p.G60>?(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACTCTTCTTGTCCAGCTGTA	0.458000	Q61K(CHP212_AUTONOMIC_GANGLIA)|Q61K(HCC15_LUNG)|Q61K(HS936T_SKIN)|Q61K(HS944T_SKIN)|Q61K(HT1080_SOFT_TISSUE)|Q61K(HUT78_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(NCIH1299_LUNG)|Q61K(NCIH2087_LUNG)|Q61K(OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(SKNAS_AUTONOMIC_GANGLIA)|Q61K(SKNSH_AUTONOMIC_GANGLIA)|Q61K(TYKNU_OVARY)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			65	109					7.75977e-34	1.8626e-33	0.003610	1	0
TREML3P	340206	broad.mit.edu	37	6	41177423	41177423	+	RNA	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:41177423G>A	ENST00000564680.1	-	0	449																											CAGAGACCAGGAGTTTGGGGC	0.592000													3	8					0	0	0.004672	0	0
SLC37A1	54020	broad.mit.edu	37	21	43963547	43963547	+	Splice_Site	SNP	A	A	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr21:43963547A>G	ENST00000352133.2	+	8	1547	c.563_splice	c.e8-1	p.R189_splice	SLC37A1_ENST00000398341.3_Splice_Site_p.R189_splice			P57057	GLPT_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 1	189					carbohydrate transport|transmembrane transport	integral to membrane				breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|liver(2)|lung(3)	15						GTGCTGCAGGAGAGGTTTGAT	0.567000													75	139					0	0	0.003610	0	0
CDH22	64405	broad.mit.edu	37	20	44845504	44845504	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:44845504C>T	ENST00000372262.3	-	4	1199	c.799G>A	c.(799-801)Gtc>Atc	p.V267I	CDH22_ENST00000537909.1_Missense_Mutation_p.V267I|CDH22_ENST00000474438.1_5'UTR	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	267	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				ACGTCGGTGACTACGATGGTG	0.627000													51	86					0	0	0.003610	0	0
RRN3P2	653390	broad.mit.edu	37	16	29105704	29105704	+	RNA	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:29105704G>A	ENST00000564580.1	+	0	843																											ATCAAAGGGTGGAAACAGCTA	0.348000													3	16					0	0	0.004672	0	0
THOC3	84321	broad.mit.edu	37	5	175387026	175387026	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:175387026G>A	ENST00000265097.4	-	6	1092	c.1002C>T	c.(1000-1002)gaC>gaT	p.D334D	THOC3_ENST00000514861.1_Silent_p.D149D	NM_032361.2	NP_115737.1	Q96J01	THOC3_HUMAN	THO complex 3	334					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	transcription export complex	RNA binding			endometrium(1)|kidney(1)|large_intestine(2)	4	all_cancers(89;0.00406)|Renal(175;0.000269)|Lung NSC(126;0.0103)|all_lung(126;0.0164)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Kidney(146;0.0965)		CCCGGCTGCTGTCATATTTGC	0.547000													23	40					0	0	0.003214	0	0
TEK	7010	broad.mit.edu	37	9	27168557	27168557	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:27168557C>T	ENST00000380036.4	+	3	871	c.429C>T	c.(427-429)ttC>ttT	p.F143F	TEK_ENST00000406359.4_Silent_p.F143F|TEK_ENST00000519097.1_Silent_p.F39F	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	143					angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		ACATATCTTTCAAAAAGGTAT	0.343000													17	33					0	0	0.001882	0	0
DNAH8	1769	broad.mit.edu	37	6	38906695	38906695	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:38906695C>T	ENST00000359357.3	+	77	11541	c.11287C>T	c.(11287-11289)Ctc>Ttc	p.L3763F	DNAH8_ENST00000449981.2_Missense_Mutation_p.L3980F|DNAH8_ENST00000441566.1_Missense_Mutation_p.L3727F|RP1-207H1.3_ENST00000416948.1_RNA					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GTTTGTACTCCTCATGACCTT	0.383000													32	47					0	0	0.002836	0	0
PPP1R26	9858	broad.mit.edu	37	9	138378269	138378269	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:138378269C>T	ENST00000356818.2	+	4	2462	c.1913C>T	c.(1912-1914)cCc>cTc	p.P638L	PPP1R26_ENST00000605660.1_Missense_Mutation_p.P638L|PPP1R26_ENST00000604351.1_Missense_Mutation_p.P638L|PPP1R26_ENST00000605286.1_Missense_Mutation_p.P638L|PPP1R26_ENST00000602993.1_Intron|PPP1R26_ENST00000401470.3_Missense_Mutation_p.P638L	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	638						nucleolus	protein binding										CGAGACCTGCCCATCCAGGGC	0.657000													13	28					0	0	0.001368	0	0
OR2G3	81469	broad.mit.edu	37	1	247769173	247769173	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:247769173G>A	ENST00000320002.2	+	1	318	c.286G>A	c.(286-288)Ggt>Agt	p.G96S	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CACTTACGGTGGTTGTGTGGC	0.483000													110	309					0	0	0.003610	0	0
HMGXB4	10042	broad.mit.edu	37	22	35661316	35661316	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:35661316C>T	ENST00000216106.5	+	5	1063	c.935C>T	c.(934-936)tCt>tTt	p.S312F	HMGXB4_ENST00000444518.2_Missense_Mutation_p.S203F	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	312					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ATAGATGATTCTTACCGAGAA	0.423000													22	58					0	0	0.003330	0	0
TMEM26	219623	broad.mit.edu	37	10	63188782	63188782	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:63188782G>A	ENST00000399298.3	-	4	875	c.507C>T	c.(505-507)atC>atT	p.I169I	TMEM26_ENST00000399293.1_Silent_p.I169I	NM_178505.6	NP_848600.2	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	169						integral to membrane				kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	18	Prostate(12;0.0112)					GATCTCGAGTGATCCCGCCTC	0.433000													23	9					0	0	0.001882	0	0
SP6	80320	broad.mit.edu	37	17	45925190	45925190	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:45925190C>T	ENST00000536300.1	-	2	937	c.606G>A	c.(604-606)ctG>ctA	p.L202L	SP6_ENST00000342234.2_Silent_p.L202L	NM_001258248.1	NP_001245177.1	Q3SY56	SP6_HUMAN	Sp6 transcription factor	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(5)|prostate(1)|skin(1)	8						GGCTGGAATCCAGCCCTTGAG	0.701000													10	10					0	0	0.000443	0	0
EFNB1	1947	broad.mit.edu	37	X	68060377	68060377	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chrX:68060377G>A	ENST00000204961.4	+	5	1701	c.921G>A	c.(919-921)cgG>cgA	p.R307R		NM_004429.4	NP_004420.1	P98172	EFNB1_HUMAN	ephrin-B1	307					cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	22						TTCCCTTACGGACTACAGAGA	0.637000													17	8					0	0	0.000958	0	0
CSRNP1	64651	broad.mit.edu	37	3	39185751	39185751	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:39185751G>A	ENST00000273153.5	-	4	834	c.657C>T	c.(655-657)atC>atT	p.I219I	CSRNP1_ENST00000514182.1_Silent_p.I219I	NM_033027.3	NP_149016.2	Q96S65	CSRN1_HUMAN	cysteine-serine-rich nuclear protein 1	219					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|skin(3)	24						CCTCCCGATCGATCCTTCGCA	0.632000													29	56					0	0	0.002096	0	0
CLCC1	23155	broad.mit.edu	37	1	109477402	109477402	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:109477402G>T	ENST00000369971.2	-	11	1675	c.1546C>A	c.(1546-1548)Cag>Aag	p.Q516K	CLCC1_ENST00000356970.2_Missense_Mutation_p.Q516K|CLCC1_ENST00000415331.1_Missense_Mutation_p.Q466K|AKNAD1_ENST00000357393.4_Intron|CLCC1_ENST00000482889.1_Intron|CLCC1_ENST00000348264.2_Missense_Mutation_p.Q331K|CLCC1_ENST00000369968.2_Missense_Mutation_p.Q331K|CLCC1_ENST00000369969.2_Missense_Mutation_p.Q395K|CLCC1_ENST00000369970.3_Missense_Mutation_p.Q466K|CLCC1_ENST00000302500.4_Missense_Mutation_p.Q395K|CLCC1_ENST00000369976.1_Intron	NM_001048210.1	NP_001041675.1	Q96S66	CLCC1_HUMAN	chloride channel CLIC-like 1	516						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|liver(1)|skin(1)	14		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		GACTTGAGCTGGGCCTTTTCC	0.597000													10	722					2.17888e-05	5.15361e-05	0.000443	1	0
OR5R1	219479	broad.mit.edu	37	11	56184908	56184908	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:56184908G>A	ENST00000312253.1	-	1	800	c.801C>T	c.(799-801)tcC>tcT	p.S267S		NM_001004744.1	NP_001004744.1	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R, member 1	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(17)|ovary(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(21;0.00448)					CTGTGTCCAAGGAGTGATTTG	0.423000													21	17					0	0	0.001882	0	0
TRAV6	6956	broad.mit.edu	37	14	22237058	22237058	+	RNA	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr14:22237058G>A	ENST00000390428.3	+	0	142																											AGATAGAACAGAATTCCGAGG	0.473000													14	5					0	0	0.004007	0	0
NEK5	341676	broad.mit.edu	37	13	52686462	52686462	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr13:52686462C>T	ENST00000355568.4	-	5	393	c.254G>A	c.(253-255)gGa>gAa	p.G85E		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	85	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		GAGATCCCCTCCATCACAATA	0.358000													20	48					0	0	0.002299	0	0
LRRFIP1	9208	broad.mit.edu	37	2	238628209	238628209	+	Splice_Site	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:238628209C>T	ENST00000244815.5	+	3	437	c.198_splice	c.e3+1	p.S66_splice	LRRFIP1_ENST00000392000.4_Splice_Site_p.S66_splice|LRRFIP1_ENST00000308482.9_Splice_Site_p.S98_splice|LRRFIP1_ENST00000289175.6_Intron	NM_004735.3	NP_004726.2	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting protein 1	66					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding	p.S66L(2)		NS(1)|breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	29		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		AGAAACACATCGGTTAGTACC	0.373000													16	24					0	0	0.001216	0	0
NRXN3	9369	broad.mit.edu	37	14	79181167	79181167	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr14:79181167G>A	ENST00000554719.1	+	5	1101	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K	NRXN3_ENST00000335750.5_Missense_Mutation_p.E204K	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	210	Laminin G-like.				angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CCTGGACCTGGAAGGAGACAT	0.592000													62	32					0	0	0.003610	0	0
PSPH	5723	broad.mit.edu	37	7	56079530	56079530	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:56079530G>A	ENST00000395471.3	-	8	1408	c.603C>T	c.(601-603)atC>atT	p.I201I	PSPH_ENST00000275605.3_Silent_p.I201I|PSPH_ENST00000459834.1_5'UTR			P78330	SERB_HUMAN	phosphoserine phosphatase	201					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity	p.I201I(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(1)|skin(1)	11	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTTGTTGCCTGATCACATTTC	0.358000													19	61					0	0	0.001882	0	0
PAX8	7849	broad.mit.edu	37	2	113994297	113994297	+	Splice_Site	SNP	C	C	T	rs33934602		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:113994297C>T	ENST00000429538.3	-	8	973	c.777_splice	c.e8-1	p.G260_splice	AC016683.6_ENST00000437551.1_RNA|AC016683.6_ENST00000556070.1_RNA|AC016683.6_ENST00000445745.1_RNA|PAX8_ENST00000397647.3_Intron|PAX8_ENST00000263334.5_Splice_Site_p.G260_splice|AC016683.6_ENST00000451179.1_RNA|PAX8_ENST00000348715.5_Splice_Site_p.G260_splice|AC016683.6_ENST00000333145.5_RNA|AC016683.6_ENST00000436293.2_RNA|AC016683.6_ENST00000422956.1_RNA|AC016683.6_ENST00000456685.1_RNA|PAX8_ENST00000263335.7_Intron|AC016683.6_ENST00000553869.2_RNA	NM_003466.3	NP_003457.1	Q06710	PAX8_HUMAN	paired box 8	260					branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity		PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						CGGGTAGAGGCCCTGGGGAGC	0.622000			T	PPARG	follicular thyroid		Thyroid dysgenesis						4	6					0	0	0.000248	0	0
MAATS1	89876	broad.mit.edu	37	3	119462918	119462918	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:119462918G>A	ENST00000273390.5	+	14	1854	c.1777G>A	c.(1777-1779)Gag>Aag	p.E593K		NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		ACTGCAGGAGGAGAGGAGGAT	0.577000													45	64					0	0	0.003610	0	0
DSCAM	1826	broad.mit.edu	37	21	41711317	41711317	+	Silent	SNP	G	G	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr21:41711317G>T	ENST00000400454.1	-	7	1713	c.1236C>A	c.(1234-1236)gcC>gcA	p.A412A		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	412	Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TTTCACTAAAGGCAGAAATAA	0.438000													11	7					1.08611e-07	2.57729e-07	0.000978	1	0
SELE	6401	broad.mit.edu	37	1	169702093	169702093	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:169702093C>T	ENST00000333360.7	-	3	223	c.84G>A	c.(82-84)acG>acA	p.T28T	SELE_ENST00000367777.1_Silent_p.T28T|SELE_ENST00000367776.1_Silent_p.T28T|SELE_ENST00000367781.4_Silent_p.T28T|SELE_ENST00000367779.4_Silent_p.T28T|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367780.4_Silent_p.T28T|SELE_ENST00000367782.4_Silent_p.T28T|SELE_ENST00000367775.1_Silent_p.T28T|SELE_ENST00000367774.1_Silent_p.T28T	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	28	C-type lectin.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					TCATAGCTTCCGTGGAGGTGT	0.418000													31	108					0	0	0.002096	0	0
CNTN4	152330	broad.mit.edu	37	3	2928759	2928759	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:2928759G>A	ENST00000397461.1	+	9	1175	c.791G>A	c.(790-792)gGa>gAa	p.G264E	CNTN4_ENST00000418658.1_Missense_Mutation_p.G264E|CNTN4_ENST00000427331.1_Missense_Mutation_p.G264E|CNTN4_ENST00000358480.3_Missense_Mutation_p.G45E	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	264	Ig-like C2-type 3.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AGAGCTGATGGAAAGCCAATA	0.393000													7	16					0	0	0.003080	0	0
RPS16	6217	broad.mit.edu	37	19	39924333	39924333	+	Silent	SNP	C	C	T	rs11555712		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:39924333C>T	ENST00000339471.4	-	3	259	c.219G>A	c.(217-219)aaG>aaA	p.K73K	RPS16_ENST00000251453.3_Silent_p.K73K|RPS16_ENST00000599539.1_Silent_p.K73K|RPS16_ENST00000601655.1_Silent_p.K56K			P62249	RS16_HUMAN	ribosomal protein S16	73					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			central_nervous_system(1)|large_intestine(2)|lung(2)|skin(2)	7	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;4.14e-26)|all cancers(26;2.68e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GACCACCACCCTTTACACGGA	0.567000													24	27					0	0	0.003330	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751613	140751613	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:140751613T>C	ENST00000576222.1	+	1	1783	c.1652T>C	c.(1651-1653)tTg>tCg	p.L551S	PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCGCGTGTTGGTGGACGAC	0.667000													18	16					0	0	0.006122	0	0
PRRC2A	7916	broad.mit.edu	37	6	31592079	31592079	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:31592079T>G	ENST00000376033.2	+	4	566	c.332T>G	c.(331-333)cTg>cGg	p.L111R	PRRC2A_ENST00000376007.4_Missense_Mutation_p.L111R|PRRC2A_ENST00000469577.1_3'UTR	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	111	4 X 57 AA type A repeats.			ESQPLPASQTPASNQPK -> NRTTAGFTDACLQPAE (in Ref. 8; CAA78744).		cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						TCGCAGCCACTGCCGGCTTCA	0.607000													14	150					0	0	0.003163	0	0
ZNF585A	199704	broad.mit.edu	37	19	37644195	37644195	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:37644195G>A	ENST00000356958.4	-	5	864	c.606C>T	c.(604-606)ttC>ttT	p.F202F	ZNF585A_ENST00000392157.2_Silent_p.F147F|ZNF585A_ENST00000355533.2_Silent_p.F147F|ZNF585A_ENST00000292841.5_Silent_p.F147F|ZNF585A_ENST00000588723.1_Intron			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCTGATGCCTGAAGAGGGACG	0.388000													31	67					0	0	0.002445	0	0
CUL9	23113	broad.mit.edu	37	6	43164398	43164398	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:43164398G>A	ENST00000252050.4	+	11	2685	c.2601G>A	c.(2599-2601)gcG>gcA	p.A867A	CUL9_ENST00000354495.3_Silent_p.A757A|CUL9_ENST00000372647.2_Silent_p.A867A	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	867					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						CTTCTGCAGCGAGAAATGGCT	0.517000													73	197					0	0	0.003610	0	0
MYH1	4619	broad.mit.edu	37	17	10401153	10401153	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:10401153C>T	ENST00000226207.5	-	31	4357	c.4263G>A	c.(4261-4263)acG>acA	p.T1421T	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1421						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GCCTCTGCTTCGTCTTCTCAA	0.473000													22	45					0	0	0.002299	0	0
AHCTF1	25909	broad.mit.edu	37	1	247079503	247079503	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:247079503G>A	ENST00000366508.1	-	3	557	c.421C>T	c.(421-423)Ctc>Ttc	p.L141F	AHCTF1_ENST00000391829.2_Missense_Mutation_p.L106F|AHCTF1_ENST00000326225.3_Missense_Mutation_p.L115F			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	106	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TAAAGACAGAGAACACTCCCT	0.378000													15	35					0	0	0.001216	0	0
ZBP1	81030	broad.mit.edu	37	20	56191474	56191474	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:56191474C>T	ENST00000340462.4	-	2	365	c.85G>A	c.(85-87)Gtg>Atg	p.V29M	ZBP1_ENST00000395822.3_Intron|ZBP1_ENST00000343535.4_Missense_Mutation_p.V29M|ZBP1_ENST00000541799.1_Missense_Mutation_p.V29M|ZBP1_ENST00000371173.3_Missense_Mutation_p.V29M|ZBP1_ENST00000538947.1_5'UTR			Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	29						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			GCAAGTTTCACCGGGGAGCCA	0.577000													53	103					0	0	0.003610	0	0
CYP3A43	64816	broad.mit.edu	37	7	99461188	99461188	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:99461188G>A	ENST00000354829.2	+	12	1385	c.1282G>A	c.(1282-1284)Gat>Aat	p.D428N	CYP3A43_ENST00000417625.1_Missense_Mutation_p.D318N|CYP3A43_ENST00000342499.4_Intron|CYP3A43_ENST00000312017.5_Intron|CYP3A43_ENST00000444905.1_Intron|CYP3A43_ENST00000477658.1_Intron|CYP3A43_ENST00000222382.5_Missense_Mutation_p.D429N|CYP3A43_ENST00000415413.1_Missense_Mutation_p.D217N	NM_022820.3|NM_057095.1	NP_073731.1|NP_476436.1	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 43	428			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	GGACAGCATAGATCTTTACAG	0.378000													13	68					0	0	0.003163	0	0
PILRB	29990	broad.mit.edu	37	7	99956404	99956404	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:99956404C>T	ENST00000310771.4	+	16	2652	c.156C>T	c.(154-156)ccC>ccT	p.P52P	PILRB_ENST00000444874.1_Intron|PILRB_ENST00000448382.1_Intron|PILRB_ENST00000444073.1_Silent_p.P52P|PILRB_ENST00000452089.1_Silent_p.P52P			Q9UKJ0	PILRB_HUMAN	paired immunoglobin-like type 2 receptor beta	52	Ig-like V-type.				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGGAAATCCCCTTCTCCTTCT	0.542000													20	27					0	0	0.001523	0	0
ABLIM1	3983	broad.mit.edu	37	10	116251620	116251620	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:116251620G>A	ENST00000533213.2	-	7	1033	c.732C>T	c.(730-732)taC>taT	p.Y244Y	ABLIM1_ENST00000277895.5_Silent_p.Y304Y|ABLIM1_ENST00000369253.2_5'UTR|ABLIM1_ENST00000392952.3_5'UTR|ABLIM1_ENST00000369266.3_5'UTR|ABLIM1_ENST00000369252.4_Silent_p.Y244Y			O14639	ABLM1_HUMAN	actin binding LIM protein 1	304	LIM zinc-binding 3.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		AGCTGGGGTGGTAATGTTTGT	0.453000													76	121					0	0	0.003610	0	0
PROKR2	128674	broad.mit.edu	37	20	5282887	5282887	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:5282887G>A	ENST00000546004.1	-	3	1200	c.954C>T	c.(952-954)gtC>gtT	p.V318V	PROKR2_ENST00000217270.3_Silent_p.V318V			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	318						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						CGATGCACTCGACCACGTAGA	0.512000										HNSCC(71;0.22)			50	106					0	0	0.003610	0	0
PPP3R2	5535	broad.mit.edu	37	9	104356828	104356828	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:104356828C>T	ENST00000374806.1	-	1	455	c.385G>A	c.(385-387)Gac>Aac	p.D129N	GRIN3A_ENST00000361820.3_Intron	NM_147180.2	NP_671709.1	Q96LZ3	CANB2_HUMAN	protein phosphatase 3, regulatory subunit B, beta	126	EF-hand 4.						calcium ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	AGCTGCCAGTCCGTCAGGTTG	0.507000													26	55					0	0	0.005443	0	0
BEGAIN	57596	broad.mit.edu	37	14	101004527	101004527	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr14:101004527C>T	ENST00000556751.1	-	5	4773	c.1369G>A	c.(1369-1371)Ggg>Agg	p.G457R	BEGAIN_ENST00000355173.2_Missense_Mutation_p.G521R|BEGAIN_ENST00000443071.2_Missense_Mutation_p.G521R			Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	521						cytoplasm|membrane	protein binding			cervix(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)	14		Melanoma(154;0.212)				AGCCTGTCCCCGTCCCCCCCC	0.736000													14	4					0	0	0.003163	0	0
CD58	965	broad.mit.edu	37	1	117064557	117064557	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:117064557A>T	ENST00000457047.2	-	4	730	c.677T>A	c.(676-678)aTt>aAt	p.I226N	CD58_ENST00000369487.3_Missense_Mutation_p.I226N|CD58_ENST00000369489.5_Missense_Mutation_p.I226N	NM_001144822.1	NP_001138294.1	P19256	LFA3_HUMAN	CD58 molecule	226					blood coagulation|cell-cell adhesion|leukocyte migration	anchored to membrane|integral to plasma membrane	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(3)|urinary_tract(1)	9	Lung SC(450;0.225)	all_cancers(81;0.000363)|all_lung(203;0.000118)|all_epithelial(167;0.000149)|Lung NSC(69;0.000577)		Lung(183;0.0086)|LUSC - Lung squamous cell carcinoma(189;0.0528)|Colorectal(144;0.0775)|all cancers(265;0.109)|Epithelial(280;0.118)|COAD - Colon adenocarcinoma(174;0.121)		ACATGTTGTAATTACTGCTAA	0.289000													7	10					0	0	0.003080	0	0
DNAJC7	7266	broad.mit.edu	37	17	40152539	40152539	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:40152539C>T	ENST00000457167.4	-	2	363	c.127G>A	c.(127-129)Gat>Aat	p.D43N	DNAJC7_ENST00000426588.3_5'UTR|DNAJC7_ENST00000316603.7_Intron	NM_003315.3	NP_003306.3	Q99615	DNJC7_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 7	43					chaperone cofactor-dependent protein refolding	cytoplasm|cytoskeleton|nucleus	heat shock protein binding|unfolded protein binding	p.D33Y(1)		endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)	9		all_cancers(22;0.00273)|Breast(137;0.00104)|all_epithelial(22;0.0305)				TCATTGTAATCTTTCTTGGCA	0.318000													22	54					0	0	0.005443	0	0
PSMD4	5710	broad.mit.edu	37	1	151238481	151238481	+	Splice_Site	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:151238481C>T	ENST00000368884.3	+	7	736	c.654_splice	c.e7-1	p.A219_splice	PSMD4_ENST00000368881.4_Splice_Site_p.A219_splice	NM_002810.2	NP_002801.1	P55036	PSMD4_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	219	Essential for ubiquitin-binding.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|lung(7)	11	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTTCACCAGGCCCTTCGTGTA	0.627000													30	45					0	0	0.003271	0	0
SEMA4C	54910	broad.mit.edu	37	2	97526434	97526434	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:97526434C>T	ENST00000305476.5	-	15	2563	c.2431G>A	c.(2431-2433)Gat>Aat	p.D811N		NM_017789.4	NP_060259.4	Q9C0C4	SEM4C_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	811					muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			NS(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	17						CTCAGTTCATCCGCGAGCTCA	0.652000													58	71					0	0	0.003610	0	0
PSMD4	5710	broad.mit.edu	37	1	151238482	151238482	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:151238482C>T	ENST00000368884.3	+	7	737	c.657C>T	c.(655-657)gcC>gcT	p.A219A	PSMD4_ENST00000368881.4_Silent_p.A219A	NM_002810.2	NP_002801.1	P55036	PSMD4_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	219	Essential for ubiquitin-binding.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|lung(7)	11	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTCACCAGGCCCTTCGTGTAT	0.622000													31	45					0	0	0.003755	0	0
OR6M1	390261	broad.mit.edu	37	11	123676656	123676656	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:123676656C>T	ENST00000309154.2	-	1	439	c.402G>A	c.(400-402)atG>atA	p.M134I		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		CCCTGCTGTTCATGATGACCG	0.527000													16	15					0	0	0.004990	0	0
ATP8B3	148229	broad.mit.edu	37	19	1785585	1785585	+	Silent	SNP	G	G	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:1785585G>C	ENST00000539485.1	-	26	3539	c.3306C>G	c.(3304-3306)gtC>gtG	p.V1102V	ATP8B3_ENST00000525591.1_Silent_p.V1055V|ATP8B3_ENST00000310127.6_Silent_p.V1092V			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	1092					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGAAGAAGTTGACCAGAGAGG	0.612000													13	38					0	0	0.001368	0	0
JUP	3728	broad.mit.edu	37	17	39777916	39777916	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:39777916C>T	ENST00000540235.1	-	7	1239	c.1240G>A	c.(1240-1242)Gag>Aag	p.E414K	KRT17_ENST00000311208.8_Missense_Mutation_p.E255K			P14923	PLAK_HUMAN	junction plakoglobin	0					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		TCACGCATCTCGTTGAGGATG	0.587000													23	46					0	0	0.003954	0	0
PKD1	5310	broad.mit.edu	37	16	2161314	2161314	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:2161314C>T	ENST00000262304.4	-	15	4062	c.3854G>A	c.(3853-3855)cGg>cAg	p.R1285Q	PKD1_ENST00000423118.1_Missense_Mutation_p.R1285Q	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	1285	PKD 7.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GTGCAGGCTCCGGGCCAGGTG	0.706000													21	23					0	0	0.001882	0	0
DOPEY1	23033	broad.mit.edu	37	6	83851761	83851761	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:83851761C>T	ENST00000349129.2	+	24	5797	c.5537C>T	c.(5536-5538)aCc>aTc	p.T1846I	DOPEY1_ENST00000484282.1_3'UTR|DOPEY1_ENST00000369739.3_Missense_Mutation_p.T1837I|DOPEY1_ENST00000237163.5_Missense_Mutation_p.T1827I	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	1846					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		ACCACCAGGACCAAGGTATGT	0.408000													37	45					0	0	0.001485	0	0
DUOX1	53905	broad.mit.edu	37	15	45433531	45433531	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:45433531C>T	ENST00000321429.4	+	15	2014	c.1607C>T	c.(1606-1608)aCc>aTc	p.T536I	DUOX1_ENST00000561166.1_Missense_Mutation_p.T182I|DUOX1_ENST00000389037.3_Missense_Mutation_p.T536I	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	536	Peroxidase-like; mediates peroxidase activity.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CGAAATACCACCCTGCAGGAC	0.532000													36	37					0	0	0.003755	0	0
VEGFA	7422	broad.mit.edu	37	6	43752296	43752296	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:43752296G>A	ENST00000372067.3	+	7	1607	c.1113G>A	c.(1111-1113)cgG>cgA	p.R371R	VEGFA_ENST00000523950.1_Silent_p.R191R|VEGFA_ENST00000518689.1_Silent_p.R209R|VEGFA_ENST00000372077.4_Silent_p.R147R|VEGFA_ENST00000417285.2_3'UTR|VEGFA_ENST00000518824.1_Intron|VEGFA_ENST00000457104.2_Silent_p.R137R|VEGFA_ENST00000230480.6_Silent_p.R163R|VEGFA_ENST00000523125.1_3'UTR|VEGFA_ENST00000413642.3_Silent_p.R389R|VEGFA_ENST00000520948.1_Silent_p.R215R|VEGFA_ENST00000372055.4_Silent_p.R412R|VEGFA_ENST00000324450.6_Silent_p.R317R|VEGFA_ENST00000425836.2_Silent_p.R395R|VEGFA_ENST00000482630.2_Intron|VEGFA_ENST00000523873.1_Silent_p.R232R|VEGFA_ENST00000372064.4_Silent_p.R327R	NM_001025366.2|NM_001025367.2|NM_001025368.2|NM_001025369.2|NM_001033756.2|NM_001171623.1|NM_001171624.1|NM_001171625.1|NM_001171626.1|NM_001171627.1|NM_001171629.1|NM_003376.5	NP_001020537.2|NP_001020538.2|NP_001020539.2|NP_001020540.2|NP_001028928.1|NP_001165094.1|NP_001165095.1|NP_001165096.1|NP_001165097.1|NP_001165098.1|NP_001165100.1|NP_003367.4	P15692	VEGFA_HUMAN	vascular endothelial growth factor A	232					basophil chemotaxis|cellular response to hypoxia|induction of positive chemotaxis|platelet activation|platelet degranulation|platelet-derived growth factor receptor signaling pathway|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cell adhesion|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of leukocyte migration|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular permeability|regulation of cell shape|vascular endothelial growth factor receptor signaling pathway|vasculogenesis	cell surface|extracellular space|membrane|platelet alpha granule lumen	cell surface binding|chemoattractant activity|cytokine activity|fibronectin binding|growth factor activity|heparin binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|vascular endothelial growth factor receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	9	all_cancers(18;5.46e-07)|all_epithelial(2;5.96e-08)|Lung NSC(15;0.000157)|all_lung(25;0.000486)|Hepatocellular(11;0.00309)		all cancers(41;0.000413)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0742)|OV - Ovarian serous cystadenocarcinoma(102;0.196)		Atorvastatin(DB01076)|Bevacizumab(DB00112)|Carvedilol(DB01136)|Ginkgo biloba(DB01381)|Gliclazide(DB01120)|Minocycline(DB01017)|Ranibizumab(DB01270)|Simvastatin(DB00641)	AGCCGAGGCGGTGAGCCGGGC	0.587000													46	122					0	0	0.003610	0	0
CSMD2	114784	broad.mit.edu	37	1	33998707	33998707	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:33998707C>T	ENST00000373381.4	-	64	10290	c.10114G>A	c.(10114-10116)Gag>Aag	p.E3372K		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3228						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTGCGGTGCTCGGAGCCACCC	0.667000													14	21					0	0	0.003163	0	0
CACNA1A	773	broad.mit.edu	37	19	13386718	13386718	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:13386718C>T	ENST00000360228.5	-	24	3934	c.3935G>A	c.(3934-3936)tGg>tAg	p.W1312*	CACNA1A_ENST00000573710.2_Nonsense_Mutation_p.W1313*	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1313					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GAGAATATTCCAGAGGTCACG	0.577000													19	36					0	0	0.001882	0	0
ERBB2	2064	broad.mit.edu	37	17	37883074	37883074	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:37883074G>A	ENST00000406381.2	+	27	3397	c.2887G>A	c.(2887-2889)Gac>Aac	p.D963N	ERBB2_ENST00000541774.1_Missense_Mutation_p.D978N|ERBB2_ENST00000540147.1_Missense_Mutation_p.D963N|ERBB2_ENST00000445658.2_Missense_Mutation_p.D717N|ERBB2_ENST00000269571.5_Missense_Mutation_p.D993N|ERBB2_ENST00000584601.1_Missense_Mutation_p.D963N|ERBB2_ENST00000584450.1_Missense_Mutation_p.D993N	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	993	Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ACAGAATGAGGACTTGGGCCC	0.612000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			17	78					0	0	0.004990	0	0
SETD2	29072	broad.mit.edu	37	3	47162123	47162123	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:47162123G>A	ENST00000409792.3	-	3	4045	c.4003C>T	c.(4003-4005)Cgt>Tgt	p.R1335C		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1335					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TCTTCTTCACGATCATCTGTT	0.458000			"""N, F, S, Mis"""		clear cell renal carcinoma								14	37					0	0	0.004007	0	0
OR6C4	341418	broad.mit.edu	37	12	55945190	55945190	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:55945190C>T	ENST00000394256.2	+	1	208	c.180C>T	c.(178-180)ttC>ttT	p.F60F	RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA	NM_001005494.1	NP_001005494.1	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C, member 4	60					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	11						TGTATTTCTTCCTCCGGAATT	0.418000													42	66					0	0	0.002522	0	0
MZF1	7593	broad.mit.edu	37	19	59081865	59081865	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:59081865G>A	ENST00000215057.2	-	3	986	c.426C>T	c.(424-426)gtC>gtT	p.V142V	AC016629.8_ENST00000593642.1_RNA|MZF1_ENST00000599369.1_Silent_p.V142V|MZF1_ENST00000594234.1_Silent_p.V142V|AC016629.8_ENST00000600726.1_RNA|AC016629.8_ENST00000600534.1_RNA|MZF1_ENST00000594108.1_Silent_p.V142V	NM_001267033.1|NM_198055.1	NP_001253962.1|NP_932172.1	P28698	MZF1_HUMAN	myeloid zinc finger 1	142					viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		TCTCTGATAGGACCTCCTGGC	0.602000													14	26					0	0	0.003163	0	0
TRBV9	28586	broad.mit.edu	37	7	142239828	142239828	+	RNA	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:142239828G>A	ENST00000390363.2	-	0	98																											GAATCCACTGGGCCTGTGTGT	0.512000													19	53					0	0	0.001523	0	0
ZBP1	81030	broad.mit.edu	37	20	56191489	56191489	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:56191489C>T	ENST00000340462.4	-	2	350	c.70G>A	c.(70-72)Gag>Aag	p.E24K	ZBP1_ENST00000395822.3_Intron|ZBP1_ENST00000343535.4_Missense_Mutation_p.E24K|ZBP1_ENST00000541799.1_Missense_Mutation_p.E24K|ZBP1_ENST00000371173.3_Missense_Mutation_p.E24K|ZBP1_ENST00000538947.1_5'UTR			Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	24						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			GAGCCAGCCTCTGTCAGCACC	0.582000													50	94					0	0	0.003610	0	0
ADGRE4P	326342	broad.mit.edu	37	19	6990804	6990804	+	RNA	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:6990804C>T	ENST00000600751.1	-	0	53					NR_024075.1																						GGAACCTGCTCCCCATAGCAC	0.512000													38	95					0	0	0.001287	0	0
DNAJC22	79962	broad.mit.edu	37	12	49745140	49745140	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:49745140A>T	ENST00000549441.2	+	4	2085	c.881A>T	c.(880-882)cAt>cTt	p.H294L	DNAJC22_ENST00000395069.3_Missense_Mutation_p.H294L			Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	294	J.				protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|liver(2)|lung(1)|ovary(1)|pancreas(1)	10						GAAGAAATACATCGGAGTTAC	0.517000													24	46					0	0	0.004656	0	0
CBL	867	broad.mit.edu	37	11	119145646	119145646	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:119145646C>T	ENST00000264033.4	+	5	1228	c.852C>T	c.(850-852)ttC>ttT	p.F284F		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase	284	Cbl-PTB.|SH2-like.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(194)|kidney(3)|large_intestine(9)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		TCCAGAAATTCATTCACAAAC	0.423000			"""T, Mis S, O"""	MLL	"""AML, JMML, MDS"""				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies				35	25					0	0	0.004878	0	0
ABCA7	10347	broad.mit.edu	37	19	1063641	1063641	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:1063641C>T	ENST00000263094.6	+	43	6042	c.5811C>T	c.(5809-5811)gcC>gcT	p.A1937A	ABCA7_ENST00000433129.1_Silent_p.A1937A|ABCA7_ENST00000435683.2_Silent_p.A1799A	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	1937	ABC transporter 2.				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGCGACGGCCCTGGCGCTGG	0.697000													11	30					0	0	0.000673	0	0
MCM3AP	8888	broad.mit.edu	37	21	47674389	47674389	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr21:47674389G>A	ENST00000397708.1	-	20	4307	c.4053C>T	c.(4051-4053)ctC>ctT	p.L1351L	MCM3AP_ENST00000291688.1_Silent_p.L1351L|MCM3AP-AS1_ENST00000590829.1_RNA|MCM3AP_ENST00000467026.1_5'UTR			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1351					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					GCCTCCCAGGGAGGTGCTCAG	0.592000													17	47					0	0	0.004990	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795148	142795148	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chrX:142795148C>T	ENST00000370498.1	-	2	1283	c.530G>A	c.(529-531)gGt>gAt	p.G177D		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	177										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GTCCTCCCCACCCTCCTGTGA	0.473000													157	55					0	0	0.003610	0	0
SSX3	10214	broad.mit.edu	37	X	48211544	48211544	+	Silent	SNP	G	G	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chrX:48211544G>T	ENST00000298396.2	-	5	373	c.321C>A	c.(319-321)atC>atA	p.I107I	SSX3_ENST00000376893.3_Silent_p.I107I|SSX3_ENST00000376895.1_Silent_p.I19I	NM_021014.2	NP_066294.1	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|large_intestine(1)|lung(9)	13						CCTTCGGGAAGATTCCCTGGA	0.443000													67	30					1.94393e-27	4.65841e-27	0.003610	1	0
FAM110B	90362	broad.mit.edu	37	8	59059230	59059230	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:59059230C>T	ENST00000361488.3	+	5	1321	c.441C>T	c.(439-441)caC>caT	p.H147H	FAM110B_ENST00000520369.1_Intron	NM_147189.2	NP_671722.1	Q8TC76	F110B_HUMAN	family with sequence similarity 110, member B	147						microtubule organizing center|mitochondrion|nucleus				breast(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)	26		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				GGCCGCCCCACCGGTCGGAAG	0.657000													20	13					0	0	0.000958	0	0
PRPSAP1	5635	broad.mit.edu	37	17	74328483	74328483	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:74328483G>A	ENST00000446526.3	-	4	769	c.324C>T	c.(322-324)atC>atT	p.I108I	PRPSAP1_ENST00000324684.4_Silent_p.I5I	NM_002766.2	NP_002757.2	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate synthetase-associated protein 1	79					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17						CGTAAGCCATGATGAGCAACT	0.453000													19	58					0	0	0.001216	0	0
KIAA1549	57670	broad.mit.edu	37	7	138546124	138546124	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:138546124C>T	ENST00000440172.1	-	16	5056	c.5008G>A	c.(5008-5010)Gcc>Acc	p.A1670T	KIAA1549_ENST00000242365.4_Missense_Mutation_p.A1620T|KIAA1549_ENST00000422774.1_Missense_Mutation_p.A1670T	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1670						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						TACTGGGAGGCCGGGAAGGGA	0.632000			O	BRAF	pilocytic astrocytoma								31	36					0	0	0.001512	0	0
SNHG14	104472715	broad.mit.edu	37	15	25446288	25446288	+	RNA	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:25446288G>A	ENST00000424208.1	+	0	1863				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						CCTAGACTGTGAAATGGGAGG	0.562000													3	2					0	0	0.004672	0	0
TSSC2	650368	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	G	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:3427765G>C	ENST00000529482.1	+	0	882																											CACACGTCCTGCAGTGGCCTG	0.602000													4	38					0	0	0.000248	0	0
ANKRD11	29123	broad.mit.edu	37	16	89345485	89345485	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:89345485G>A	ENST00000301030.4	-	9	7925	c.7465C>T	c.(7465-7467)Ccc>Tcc	p.P2489S	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P2489S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2489						nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CTCACCACGGGGATGTGGAGC	0.667000													8	12					0	0	0.004482	0	0
PAPPA	5069	broad.mit.edu	37	9	118974049	118974049	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:118974049C>T	ENST00000328252.3	+	4	2125	c.1756C>T	c.(1756-1758)Ccc>Tcc	p.P586S	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	586					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						CTGCAGTGACCCCTGCATGGA	0.567000													68	88					0	0	0.003610	0	0
MYH4	4622	broad.mit.edu	37	17	10355767	10355767	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:10355767G>A	ENST00000255381.2	-	26	3424	c.3314C>T	c.(3313-3315)gCa>gTa	p.A1105V	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1105					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TAGCTGTATTGCAAGGGCTTG	0.353000													18	38					0	0	0.001216	0	0
KRT36	8689	broad.mit.edu	37	17	39646003	39646003	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:39646003C>T	ENST00000328119.6	-	1	113	c.114G>A	c.(112-114)agG>agA	p.R38R	KRT36_ENST00000393986.2_Intron	NM_003771.4	NP_003762.1	O76013	KRT36_HUMAN	keratin 36	38	Head.					intermediate filament	protein binding|structural constituent of epidermis			breast(2)|cervix(1)|kidney(2)|large_intestine(3)|lung(8)|skin(1)	17		Breast(137;0.000286)				GACTGGGGACCCTGCAGGAGC	0.627000													19	46					0	0	0.001882	0	0
AKR1B1	231	broad.mit.edu	37	7	134133183	134133183	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:134133183G>A	ENST00000285930.4	-	6	694	c.615C>T	c.(613-615)atC>atT	p.I205I		NM_001628.2	NP_001619.1	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1 (aldose reductase)	205					C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding			kidney(1)|large_intestine(5)|lung(2)|ovary(3)|prostate(1)|skin(2)	14					NADH(DB00157)|Sulindac(DB00605)	CGGTCACCACGATGCCTTTGG	0.527000													96	80					0	0	0.003610	0	0
C2orf83	56918	broad.mit.edu	37	2	228476230	228476230	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:228476230G>A	ENST00000264387.4	-	3	419	c.333C>T	c.(331-333)tcC>tcT	p.S111S	C2orf83_ENST00000409066.1_3'UTR	NM_020161.3	NP_064546.3	Q53S99	CB083_HUMAN	chromosome 2 open reading frame 83	111						membrane	folic acid binding|reduced folate carrier activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|stomach(2)	11						GGGCAGTGCTGGAGAGAGTTT	0.532000													29	98					0	0	0.003755	0	0
MUC21	394263	broad.mit.edu	37	6	30955900	30955900	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:30955900C>T	ENST00000376296.3	+	3	1871	c.1630C>T	c.(1630-1632)Cct>Tct	p.P544S	MUC21_ENST00000486149.2_Missense_Mutation_p.P90S	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	544	Cytoplasmic tail.					integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						CAGGTGGAGTCCTAACTGGTT	0.602000													29	51					0	0	0.002445	0	0
MYH15	22989	broad.mit.edu	37	3	108129630	108129630	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:108129630G>A	ENST00000273353.3	-	32	4411	c.4355C>T	c.(4354-4356)gCc>gTc	p.A1452V		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1452						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GTCCAGCCTGGCTGCTGCAGA	0.632000													10	29					0	0	0.000673	0	0
OR1M1	125963	broad.mit.edu	37	19	9204840	9204840	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:9204840G>A	ENST00000429566.3	+	1	986	c.920G>A	c.(919-921)aGa>aAa	p.R307K		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						CTGGTCAACAGAAAGATCACC	0.502000													17	23					0	0	0.006122	0	0
LAMA5	3911	broad.mit.edu	37	20	60886750	60886750	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:60886750C>T	ENST00000252999.3	-	71	9792	c.9726G>A	c.(9724-9726)ccG>ccA	p.P3242P		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	3242	Laminin G-like 3.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGAGGAGCCTCGGGGGCCCCT	0.667000													4	7					0	0	0.001984	0	0
CACNA1A	773	broad.mit.edu	37	19	13386717	13386717	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:13386717C>T	ENST00000360228.5	-	24	3935	c.3936G>A	c.(3934-3936)tgG>tgA	p.W1312*	CACNA1A_ENST00000573710.2_Nonsense_Mutation_p.W1313*	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1313					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CGAGAATATTCCAGAGGTCAC	0.577000													19	34					0	0	0.001882	0	0
TOR1AIP2	163590	broad.mit.edu	37	1	179820351	179820351	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:179820351G>A	ENST00000367612.3	-	4	569	c.182C>T	c.(181-183)cCa>cTa	p.P61L		NM_001199260.1|NM_145034.4	NP_001186189.1|NP_659471.1	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	61						endoplasmic reticulum membrane|integral to membrane	protein binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(10)|ovary(1)|skin(2)	18						TGCACTTTCTGGACCTTCTGT	0.433000													34	146					0	0	0.004878	0	0
OR4A47	403253	broad.mit.edu	37	11	48510449	48510449	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:48510449G>A	ENST00000446524.1	+	1	181	c.105G>A	c.(103-105)ttG>ttA	p.L35L		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						TCTACATTTTGACCATGGTGG	0.428000													7	1					0	0	0.003080	0	0
SH3TC1	54436	broad.mit.edu	37	4	8228805	8228805	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:8228805G>A	ENST00000539824.1	+	12	1530	c.1156G>A	c.(1156-1158)Gag>Aag	p.E386K	SH3TC1_ENST00000514274.1_3'UTR|SH3TC1_ENST00000245105.3_Missense_Mutation_p.E462K			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	462							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						CTGCCCCCAGGAGCCAGCGTC	0.607000													11	40					0	0	0.000978	0	0
CCDC38	120935	broad.mit.edu	37	12	96282255	96282255	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:96282255G>A	ENST00000344280.3	-	10	1458	c.901C>T	c.(901-903)Cca>Tca	p.P301S	SNRPF_ENST00000552085.1_Intron	NM_182496.2	NP_872302.2	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	301										breast(1)|endometrium(2)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TTTTTCTCTGGAGTGCGAGTC	0.403000													83	60					0	0	0.003610	0	0
TNNT3	7140	broad.mit.edu	37	11	1955641	1955641	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:1955641C>T	ENST00000381558.1	+	11	701	c.422C>T	c.(421-423)tCc>tTc	p.S141F	TNNT3_ENST00000446240.1_Missense_Mutation_p.S130F|TNNT3_ENST00000360603.3_Missense_Mutation_p.S143F|TNNT3_ENST00000397304.2_Missense_Mutation_p.S130F|TNNT3_ENST00000397301.1_Missense_Mutation_p.S160F|TNNT3_ENST00000381549.3_Missense_Mutation_p.S141F|TNNT3_ENST00000381561.4_Missense_Mutation_p.S152F|TNNT3_ENST00000278317.6_Missense_Mutation_p.S149F|TNNT3_ENST00000493234.1_3'UTR|TNNT3_ENST00000381589.3_Missense_Mutation_p.S147F|TNNT3_ENST00000381579.3_Missense_Mutation_p.S141F|TNNT3_ENST00000381548.3_Missense_Mutation_p.S151F			P45378	TNNT3_HUMAN	troponin T type 3 (skeletal, fast)	160					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(4)|stomach(1)	19		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		GCTCTGTCTTCCATGGGAGCC	0.597000													15	13					0	0	0.004007	0	0
TRERF1	55809	broad.mit.edu	37	6	42237138	42237138	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:42237138C>T	ENST00000541110.1	-	5	759	c.191G>A	c.(190-192)gGt>gAt	p.G64D	TRERF1_ENST00000354325.2_Missense_Mutation_p.G64D|TRERF1_ENST00000372922.4_Missense_Mutation_p.G64D|TRERF1_ENST00000340840.2_Missense_Mutation_p.G64D|TRERF1_ENST00000372917.4_Missense_Mutation_p.G64D			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	64					cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CAAGCCCAGACCATCCCGTGT	0.582000													38	98					0	0	0.004289	0	0
SLC45A4	57210	broad.mit.edu	37	8	142228438	142228438	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:142228438C>T	ENST00000519067.1	-	4	1451	c.1148G>A	c.(1147-1149)gGg>gAg	p.G383E	SLC45A4_ENST00000517878.1_Missense_Mutation_p.G434E|SLC45A4_ENST00000433583.2_Missense_Mutation_p.G376E|SLC45A4_ENST00000024061.3_Missense_Mutation_p.G383E			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	434					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GCAGTGGGACCCAAGCTTGCC	0.682000													17	134					0	0	0.000958	0	0
SATB1	6304	broad.mit.edu	37	3	18462335	18462335	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:18462335C>T	ENST00000338745.6	-	2	1859	c.125G>A	c.(124-126)aGa>aAa	p.R42K	SATB1_ENST00000454909.2_Missense_Mutation_p.R42K|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000493952.2_Missense_Mutation_p.R42K|SATB1_ENST00000417717.2_Missense_Mutation_p.R42K	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	42					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						AAGCCTTCCTCTTCCTAGCGG	0.498000													64	77					0	0	0.003610	0	0
ARHGAP11B	89839	broad.mit.edu	37	15	30925751	30925751	+	Missense_Mutation	SNP	C	C	T	rs143705474	byFrequency	TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:30925751C>T	ENST00000428041.2	+	3	404	c.259C>T	c.(259-261)Cgg>Tgg	p.R87W		NM_001039841.1	NP_001034930.1	Q3KRB8	RHGBB_HUMAN	Rho GTPase activating protein 11B	87	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|prostate(1)	8		all_lung(180;2.71e-09)|Breast(32;0.00116)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		AGGGCTTTTTCGGAAATCAGG	0.358000													25	24					0	0	0.001512	0	0
CEP63	80254	broad.mit.edu	37	3	134256013	134256013	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:134256013C>T	ENST00000337090.3	+	6	631	c.458C>T	c.(457-459)tCg>tTg	p.S153L	CEP63_ENST00000606977.1_Missense_Mutation_p.S153L|CEP63_ENST00000513612.2_Missense_Mutation_p.S153L|CEP63_ENST00000383229.3_Missense_Mutation_p.S153L|CEP63_ENST00000332047.5_Missense_Mutation_p.S153L|CEP63_ENST00000354446.3_Missense_Mutation_p.S153L			Q96MT8	CEP63_HUMAN	centrosomal protein 63kDa	153					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding	p.S153L(1)		kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CGTCAGAAATCGCTGGACTGG	0.438000													30	33					0	0	0.001512	0	0
FAM71B	153745	broad.mit.edu	37	5	156589596	156589596	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:156589596G>A	ENST00000302938.4	-	2	1775	c.1680C>T	c.(1678-1680)atC>atT	p.I560I		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	560						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCTTAGCCACGATATCTACCT	0.483000													593	280					0	0	0.003610	0	0
COQ2	27235	broad.mit.edu	37	4	84193274	84193274	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:84193274C>T	ENST00000311469.4	-	4	743	c.744G>A	c.(742-744)atG>atA	p.M248I	COQ2_ENST00000311461.7_Missense_Mutation_p.M198I|COQ2_ENST00000439031.2_Missense_Mutation_p.M211I	NM_015697.7	NP_056512.5	Q96H96	COQ2_HUMAN	coenzyme Q2 4-hydroxybenzoate polyprenyltransferase	198					glycerol metabolic process|isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrial membrane	4-hydroxybenzoate decaprenyltransferase activity|4-hydroxybenzoate nonaprenyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|ovary(1)|skin(1)|stomach(1)	8		Hepatocellular(203;0.114)				AAATTCTTTTCATTAGTGGGT	0.368000													13	21					0	0	0.001368	0	0
HEATR1	55127	broad.mit.edu	37	1	236748364	236748364	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:236748364C>T	ENST00000366582.3	-	17	2316	c.2202G>A	c.(2200-2202)caG>caA	p.Q734Q	HEATR1_ENST00000366581.2_Silent_p.Q734Q	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	734					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTATTTTTTTCTGCAACAAAC	0.383000													24	40					0	0	0.005443	0	0
NCAPD2	9918	broad.mit.edu	37	12	6637364	6637364	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:6637364C>T	ENST00000315579.5	+	25	3968	c.3169C>T	c.(3169-3171)Cgt>Tgt	p.R1057C	NCAPD2_ENST00000545962.1_Missense_Mutation_p.R1012C	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	1057					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						CTCCCAGCTTCGTCTTCTGTT	0.527000													107	173					0	0	0.003610	0	0
PTPRO	5800	broad.mit.edu	37	12	15656912	15656912	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:15656912G>A	ENST00000281171.4	+	6	1506	c.1176G>A	c.(1174-1176)ggG>ggA	p.G392G	PTPRO_ENST00000348962.2_Silent_p.G392G|PTPRO_ENST00000543886.1_Silent_p.G392G	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	392	Fibronectin type-III 4.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				AGGAACCTGGGAAATATAAGT	0.338000													21	41					0	0	0.001882	0	0
AGTR2	186	broad.mit.edu	37	X	115303742	115303742	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chrX:115303742G>A	ENST00000371906.4	+	3	399	c.209G>A	c.(208-210)tGt>tAt	p.C70Y		NM_000686.4	NP_000677.2	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	70					behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|skin(1)	24						ACACTGTTTTGTTGTCAAAAG	0.368000													28	35					0	0	0.005443	0	0
KIF24	347240	broad.mit.edu	37	9	34254447	34254447	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:34254447C>T	ENST00000379166.2	-	13	4157	c.4038G>A	c.(4036-4038)agG>agA	p.R1346R	KIF24_ENST00000379174.3_Silent_p.R1212R|KIF24_ENST00000402558.2_Silent_p.R1346R|KIF24_ENST00000345050.2_Silent_p.R1212R	NM_194313.2	NP_919289.2	Q5T7B8	KIF24_HUMAN	kinesin family member 24	1346					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(13)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	32			LUSC - Lung squamous cell carcinoma(29;0.0107)			GCAGCTGGCTCCTCAGACTCT	0.552000													22	53					0	0	0.001523	0	0
SPRR3	6707	broad.mit.edu	37	1	152975753	152975753	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:152975753C>T	ENST00000331860.3	+	3	407	c.257C>T	c.(256-258)cCt>cTt	p.P86L	SPRR3_ENST00000542696.1_Missense_Mutation_p.P86L|SPRR3_ENST00000295367.4_Missense_Mutation_p.P86L	NM_005416.2	NP_005407.1	Q9UBC9	SPRR3_HUMAN	small proline-rich protein 3	86	14 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	11	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACCAAGGTCCCTGAGCCAGGC	0.602000													13	68					0	0	0.001855	0	0
NLRP9	338321	broad.mit.edu	37	19	56244576	56244576	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:56244576C>T	ENST00000332836.2	-	2	648	c.621G>A	c.(619-621)ccG>ccA	p.P207P		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	207	NACHT.					cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CTGAAGACTCCGGCCAGTCCC	0.443000													16	23					0	0	0.003163	0	0
TRERF1	55809	broad.mit.edu	37	6	42200500	42200500	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:42200500G>A	ENST00000541110.1	-	17	3825	c.3257C>T	c.(3256-3258)tCg>tTg	p.S1086L	TRERF1_ENST00000354325.2_Missense_Mutation_p.S983L|TRERF1_ENST00000372922.4_Missense_Mutation_p.S1066L|TRERF1_ENST00000340840.2_Missense_Mutation_p.S995L|TRERF1_ENST00000372917.4_Missense_Mutation_p.S995L			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1066	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GCTCTTTACCGAACAGTACCC	0.642000													35	43					0	0	0.005524	0	0
MST1	4485	broad.mit.edu	37	3	49723120	49723120	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:49723120G>A	ENST00000449682.2	-	11	1657	c.1296C>T	c.(1294-1296)ttC>ttT	p.F432F	MST1_ENST00000383728.3_3'UTR	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	418	Kringle 4.				proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GGTTCCGGCAGAAGTTCTCCT	0.587000													24	32					0	0	0.003330	0	0
WWC1	23286	broad.mit.edu	37	5	167868736	167868736	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:167868736C>T	ENST00000265293.4	+	16	2832	c.2330C>T	c.(2329-2331)tCg>tTg	p.S777L	WWC1_ENST00000521089.1_Missense_Mutation_p.S777L|WWC1_ENST00000522140.1_3'UTR	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	777	C2.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		GGGGAGAGGTCGACTCGCTGG	0.607000													43	34					0	0	0.001951	0	0
LCMT1	51451	broad.mit.edu	37	16	25186276	25186276	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:25186276C>T	ENST00000399069.3	+	10	1058	c.903C>T	c.(901-903)ttC>ttT	p.F301F	LCMT1_ENST00000572869.1_3'UTR|LCMT1_ENST00000380966.4_Silent_p.F246F	NM_016309.2	NP_057393.2	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1	301				F -> L (in Ref. 3; BAB15270).			protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity								GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	CACTTGAATTCCTGGATGAAA	0.428000													14	9					0	0	0.001855	0	0
TRAV1-1	28693	broad.mit.edu	37	14	22090560	22090560	+	RNA	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr14:22090560G>A	ENST00000542354.1	+	0	232																											CCAGCAACATGATGGCGGAGC	0.483000													75	43					0	0	0.003610	0	0
MYH11	4629	broad.mit.edu	37	16	15831308	15831308	+	Silent	SNP	G	G	A	rs147605116		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:15831308G>A	ENST00000338282.6	-	25	3397	c.3291C>T	c.(3289-3291)gcC>gcT	p.A1097A	MYH11_ENST00000396324.3_Silent_p.A1104A|MYH11_ENST00000452625.2_Silent_p.A1104A|MYH11_ENST00000576790.1_Silent_p.A1097A|MYH11_ENST00000300036.5_Silent_p.A1097A	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1097					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CCCGCTACCTGGCCAGGGCCG	0.637000			T	CBFB	AML								27	35					0	0	0.004656	0	0
NCAPG	64151	broad.mit.edu	37	4	17812717	17812717	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:17812717G>A	ENST00000251496.2	+	1	193	c.17G>A	c.(16-18)aGg>aAg	p.R6K		NM_022346.3	NP_071741.2	Q9BPX3	CND3_HUMAN	non-SMC condensin I complex, subunit G	6					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	27				STAD - Stomach adenocarcinoma(129;0.18)		GCGGAAAGGAGGCTGCTGTCG	0.682000													4	1					0	0	0.000602	0	0
CCDC81	60494	broad.mit.edu	37	11	86123489	86123489	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:86123489G>A	ENST00000278487.3	+	10	1563	c.484G>A	c.(484-486)Gaa>Aaa	p.E162K	CCDC81_ENST00000528728.1_Missense_Mutation_p.E162K|CCDC81_ENST00000445632.2_Missense_Mutation_p.E427K|CCDC81_ENST00000354755.1_Missense_Mutation_p.E337K			Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81	427										kidney(3)|large_intestine(8)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	20		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				TAAGCAAGAGGAATATTCCCG	0.413000													29	29					0	0	0.002096	0	0
THSD7A	221981	broad.mit.edu	37	7	11513999	11513999	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:11513999G>A	ENST00000423059.3	-	8	2465	c.2214C>T	c.(2212-2214)atC>atT	p.I738I	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	738	TSP type-1 7.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CTCGCACACAGATGACTTTTC	0.507000										HNSCC(18;0.044)			60	56					0	0	0.003610	0	0
LRRC18	474354	broad.mit.edu	37	10	50122129	50122129	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:50122129G>A	ENST00000374160.3	-	1	148	c.72C>T	c.(70-72)atC>atT	p.I24I	WDFY4_ENST00000413659.2_Intron|RP11-523O18.7_ENST00000430438.1_RNA|LRRC18_ENST00000298124.3_Silent_p.I24I|WDFY4_ENST00000325239.5_Intron	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	24						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						CATCAAAAGTGATTTTGATGC	0.468000													32	28					0	0	0.002096	0	0
VN1R4	317703	broad.mit.edu	37	19	53770597	53770597	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:53770597T>G	ENST00000311170.4	-	1	375	c.322A>C	c.(322-324)Acg>Ccg	p.T108P		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	108					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		GAGCTGACCGTGATCACCTGG	0.507000										HNSCC(26;0.072)			15	45					0	0	0.003163	0	0
AC015849.16	0	broad.mit.edu	37	17	34235721	34235721	+	RNA	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:34235721C>T	ENST00000587132.1	-	0	2306																											AAATGTGTGACTTCAGTCAGG	0.453000													14	20					0	0	0.001855	0	0
ATAD5	79915	broad.mit.edu	37	17	29161414	29161414	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:29161414C>T	ENST00000321990.4	+	2	693	c.315C>T	c.(313-315)ttC>ttT	p.F105F	CTD-2349P21.11_ENST00000580873.1_RNA	NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	105					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TGGAAATGTTCTCAAATGTAG	0.338000													26	99					0	0	0.005443	0	0
SEMA5B	54437	broad.mit.edu	37	3	122645328	122645328	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:122645328C>T	ENST00000195173.4	-	9	1350	c.1047G>A	c.(1045-1047)ccG>ccA	p.P349P	SEMA5B_ENST00000357599.3_Silent_p.P349P|SEMA5B_ENST00000451055.2_Silent_p.P403P			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	349	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GGACCTCGCCCGGGCGGGAGC	0.602000													8	22					0	0	0.000443	0	0
SWSAP1	126074	broad.mit.edu	37	19	11486628	11486628	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:11486628C>T	ENST00000312423.2	+	2	685	c.626C>T	c.(625-627)cCg>cTg	p.P209L		NM_175871.3	NP_787067.2	Q6NVH7	CS039_HUMAN	SWIM-type zinc finger 7 associated protein 1	209																	ATGATCGCTCCGTGGCCCACC	0.622000													18	24					0	0	0.001882	0	0
COL6A6	131873	broad.mit.edu	37	3	130394152	130394152	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:130394152G>A	ENST00000358511.6	+	36	6734	c.6703G>A	c.(6703-6705)Gat>Aat	p.D2235N	COL6A6_ENST00000453409.2_Missense_Mutation_p.D2235N	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	2235	Nonhelical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						AAGTGGCAGAGATGATGCTAT	0.353000													5	7					0	0	0.000602	0	0
CCDC108	255101	broad.mit.edu	37	2	219892939	219892939	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:219892939A>G	ENST00000341552.5	-	12	1918	c.1835T>C	c.(1834-1836)cTc>cCc	p.L612P	CCDC108_ENST00000409865.3_Missense_Mutation_p.L601P|CCDC108_ENST00000453220.1_Missense_Mutation_p.L612P|CCDC108_ENST00000441968.1_Missense_Mutation_p.L612P|CCDC108_ENST00000410037.1_Missense_Mutation_p.L547P	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	612						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGAATCATGAGAGCCCCGTT	0.597000													11	21					0	0	0.000673	0	0
IL22RA1	58985	broad.mit.edu	37	1	24454650	24454650	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:24454650G>A	ENST00000270800.1	-	5	689	c.651C>T	c.(649-651)tgC>tgT	p.C217C		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	217	Fibronectin type-III 2.					integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		TCTTCACTCGGCACATGTAGG	0.547000													21	39					0	0	0.001882	0	0
RASAL1	8437	broad.mit.edu	37	12	113552632	113552632	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:113552632G>A	ENST00000546530.1	-	13	1439	c.1154C>T	c.(1153-1155)cCc>cTc	p.P385L	RASAL1_ENST00000261729.5_Missense_Mutation_p.P385L|RASAL1_ENST00000548055.1_Missense_Mutation_p.P385L|RASAL1_ENST00000446861.3_Missense_Mutation_p.P385L|RASAL1_ENST00000418411.2_5'UTR	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	385	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						CATCTTGCAGGGATCCAGCTC	0.642000													150	101					0	0	0.003610	0	0
COL19A1	1310	broad.mit.edu	37	6	70871825	70871825	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:70871825C>T	ENST00000322773.4	+	35	2428	c.2326C>T	c.(2326-2328)Cca>Tca	p.P776S	COL19A1_ENST00000393344.1_Missense_Mutation_p.P398S	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	776	Triple-helical region 4 (COL4).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						TCCAGGTGCTCCAGGCCCGAC	0.408000													36	58					0	0	0.002222	0	0
GPR116	221395	broad.mit.edu	37	6	46826032	46826032	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:46826032C>T	ENST00000283296.7	-	17	3896	c.3608G>A	c.(3607-3609)gGa>gAa	p.G1203E	GPR116_ENST00000265417.7_Missense_Mutation_p.G1203E|GPR116_ENST00000545669.1_Missense_Mutation_p.G632E|GPR116_ENST00000456426.2_Missense_Mutation_p.G1061E|GPR116_ENST00000362015.4_Missense_Mutation_p.G1203E	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	1203					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			TGGCTTGTCTCCAATGGAAGG	0.527000													49	128					0	0	0.003610	0	0
TBC1D2	55357	broad.mit.edu	37	9	101014073	101014073	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:101014073C>T	ENST00000375066.5	-	2	596	c.505G>A	c.(505-507)Gag>Aag	p.E169K	TBC1D2_ENST00000375064.1_Missense_Mutation_p.E169K|TBC1D2_ENST00000342112.5_Intron	NM_018421.3	NP_060891.3	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	169	Interaction with CADH1.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		GTACCTAGCTCGAGGTGCAGG	0.647000													37	70					0	0	0.001287	0	0
TOP2B	7155	broad.mit.edu	37	3	25675377	25675377	+	Silent	SNP	T	T	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:25675377T>C	ENST00000435706.2	-	8	1167	c.966A>G	c.(964-966)aaA>aaG	p.K322K	TOP2B_ENST00000264331.4_Silent_p.K327K			Q02880	TOP2B_HUMAN	topoisomerase (DNA) II beta 180kDa	327					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|skin(2)|stomach(1)	36						GCTGGAATCCTTTTTCACTCA	0.348000													3	67					0	0	0.004672	0	0
QRICH2	84074	broad.mit.edu	37	17	74288492	74288492	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:74288492G>A	ENST00000262765.5	-	4	1997	c.1818C>T	c.(1816-1818)gtC>gtT	p.V606V		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	606	Gln-rich.						protein binding	p.V606V(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						CTCCAGGTTGGACCAAACCAT	0.537000													25	31					0	0	0.003330	0	0
CD72	971	broad.mit.edu	37	9	35611857	35611857	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:35611857C>T	ENST00000396757.1	-	8	1058	c.894G>A	c.(892-894)tgG>tgA	p.W298*	CD72_ENST00000259633.4_Nonsense_Mutation_p.W298*|CD72_ENST00000490239.1_5'UTR			P21854	CD72_HUMAN	CD72 molecule	298	C-type lectin.				axon guidance|cell adhesion	integral to plasma membrane	receptor binding|sugar binding|transmembrane receptor activity	p.W298C(1)		large_intestine(5)|liver(1)|lung(6)	12			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TGAGGCCAGTCCAATATGAAT	0.433000											OREG0019172	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	39					0	0	0.000958	0	0
CYP2C19	1557	broad.mit.edu	37	10	96534887	96534887	+	Missense_Mutation	SNP	G	G	A	rs149072229		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:96534887G>A	ENST00000371321.3	+	2	323	c.241G>A	c.(241-243)Gaa>Aaa	p.E81K	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	81					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GCATGGATATGAAGTGGTGAA	0.468000													66	78					0	0	0.003610	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73175171	73175171	+	Missense_Mutation	SNP	C	C	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:73175171C>G	ENST00000286657.4	-	15	2158	c.2122G>C	c.(2122-2124)Gat>Cat	p.D708H		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	708	Cys-rich.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGGGAATTATCTCCTCCACAG	0.428000													9	24					0	0	0.004482	0	0
TSGA10	80705	broad.mit.edu	37	2	99651824	99651824	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:99651824G>A	ENST00000393483.3	-	17	2327	c.1483C>T	c.(1483-1485)Cag>Tag	p.Q495*	TSGA10_ENST00000355053.4_Nonsense_Mutation_p.Q495*|TSGA10_ENST00000539964.1_Nonsense_Mutation_p.Q495*|TSGA10_ENST00000410001.1_Nonsense_Mutation_p.Q495*	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	495					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						TGAACCTTCTGAAGCTCCTCT	0.348000													7	47					0	0	0.003080	0	0
PCLO	27445	broad.mit.edu	37	7	82580453	82580453	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:82580453C>T	ENST00000423517.2	-	6	9788	c.9451G>A	c.(9451-9453)Gaa>Aaa	p.E3151K	PCLO_ENST00000333891.8_Missense_Mutation_p.E3151K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3082	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ATGTCCGTTTCAGATGCACCT	0.423000													25	24					0	0	0.003954	0	0
CSMD3	114788	broad.mit.edu	37	8	114031326	114031326	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:114031326G>A	ENST00000297405.5	-	6	1244	c.1000C>T	c.(1000-1002)Cga>Tga	p.R334*	CSMD3_ENST00000352409.3_Nonsense_Mutation_p.R334*|CSMD3_ENST00000455883.2_Nonsense_Mutation_p.R334*|CSMD3_ENST00000343508.3_Nonsense_Mutation_p.R294*	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	334	CUB 2.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CCACGGTATCGATGATTGCTG	0.353000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			98	52					0	0	0.003610	0	0
RUFY4	285180	broad.mit.edu	37	2	218940382	218940382	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:218940382G>A	ENST00000374155.3	+	8	1637	c.1227G>A	c.(1225-1227)gaG>gaA	p.E409E	RUFY4_ENST00000463872.1_3'UTR|RUFY4_ENST00000344321.7_Silent_p.E389E|RUFY4_ENST00000441828.2_3'UTR			Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	389							metal ion binding			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(1)	10		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CTACCGTGGAGAATCCACAAG	0.592000													20	67					0	0	0.000958	0	0
THBS4	7060	broad.mit.edu	37	5	79373993	79373993	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:79373993G>A	ENST00000350881.2	+	17	2398	c.2208G>A	c.(2206-2208)gtG>gtA	p.V736V	CTD-2201I18.1_ENST00000503007.1_RNA|THBS4_ENST00000511733.1_Silent_p.V645V|CTD-2201I18.1_ENST00000514042.1_RNA	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	736	TSP C-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		ACCAGACCGTGGTCCTGGATC	0.587000													15	9					0	0	0.003163	0	0
ZNF446	55663	broad.mit.edu	37	19	58989497	58989497	+	Silent	SNP	C	C	T	rs151261644		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:58989497C>T	ENST00000596341.1	+	4	2796	c.576C>T	c.(574-576)aaC>aaT	p.N192N	ZNF446_ENST00000335841.4_Silent_p.N192N|ZNF446_ENST00000594369.1_Silent_p.N192N			Q9NWS9	ZN446_HUMAN	zinc finger protein 446	192			N -> H (in dbSNP:rs893185).		viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CTGAGGGGAACCATGGACACC	0.607000													19	38					0	0	0.002780	0	0
COL9A3	1299	broad.mit.edu	37	20	61460844	61460844	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:61460844G>A	ENST00000343916.3	+	20	1049	c.1046G>A	c.(1045-1047)gGa>gAa	p.G349E		NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	349	Triple-helical region 3 (COL3).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					GGCGAGAAGGGAGAACGGGTA	0.692000													27	67					0	0	0.002096	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													4	91					0	0	0.000602	0	0
OSGEPL1	64172	broad.mit.edu	37	2	190618689	190618689	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:190618689G>A	ENST00000519810.1	-	6	1258	c.916C>T	c.(916-918)Ctg>Ttg	p.L306L	OSGEPL1_ENST00000522700.1_Silent_p.L306L|OSGEPL1_ENST00000264151.5_Silent_p.L306L			Q9H4B0	OSGP2_HUMAN	O-sialoglycoprotein endopeptidase-like 1	306					proteolysis|tRNA processing		metalloendopeptidase activity			large_intestine(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0293)|all cancers(119;0.0831)			TTACAAAACAGAATAGCCCGA	0.378000													17	21					0	0	0.004007	0	0
PCK1	5105	broad.mit.edu	37	20	56140854	56140854	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:56140854G>A	ENST00000319441.4	+	10	2027	c.1863G>A	c.(1861-1863)caG>caA	p.Q621Q	PCK1_ENST00000543666.1_Silent_p.Q304Q	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	621					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GAATAAGCCAGATGTAATCAG	0.473000													17	22					0	0	0.004990	0	0
EXOC6	54536	broad.mit.edu	37	10	94700496	94700496	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:94700496C>T	ENST00000371552.4	+	13	1239	c.1210C>T	c.(1210-1212)Cca>Tca	p.P404S	EXOC6_ENST00000371547.4_Missense_Mutation_p.P425S|EXOC6_ENST00000443748.2_Missense_Mutation_p.P306S|EXOC6_ENST00000260762.6_Missense_Mutation_p.P409S	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6	409					protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				TTATGGTTTTCCAGTGAACCG	0.303000													102	77					0	0	0.003610	0	0
RNF183	138065	broad.mit.edu	37	9	116060144	116060144	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:116060144G>A	ENST00000478815.1	-	1	1901	c.321C>T	c.(319-321)cgC>cgT	p.R107R	RNF183_ENST00000416588.2_Silent_p.R107R|RNF183_ENST00000297894.5_Silent_p.R107R|RNF183_ENST00000441031.3_Silent_p.R107R			Q96D59	RN183_HUMAN	ring finger protein 183	107						integral to membrane	zinc ion binding			lung(1)|prostate(1)|skin(1)	3						GCAGGAAGTAGCGGCTCTTGG	0.672000													34	58					0	0	0.003755	0	0
TRAV14DV4	28669	broad.mit.edu	37	14	22392573	22392573	+	RNA	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr14:22392573C>T	ENST00000390440.2	+	0	171																											CAGGAATGTTCGTGCAGGAAA	0.443000													27	12					0	0	0.005443	0	0
ZNF679	168417	broad.mit.edu	37	7	63727142	63727142	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:63727142G>A	ENST00000421025.1	+	5	1400	c.1131G>A	c.(1129-1131)gaG>gaA	p.E377E	ZNF679_ENST00000255746.4_Silent_p.E377E	NM_001159524.1|NM_153363.2	NP_001152996.1|NP_699194.2	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	377					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						ATACTGGAGAGGAACCCTACA	0.388000													3	7					0	0	0.000248	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135911399	135911399	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:135911399G>C	ENST00000264158.8	+	19	2285	c.2242G>C	c.(2242-2244)Gct>Cct	p.A748P	RAB3GAP1_ENST00000442034.1_Missense_Mutation_p.A748P|RAB3GAP1_ENST00000487003.1_3'UTR|ZRANB3_ENST00000412849.1_Intron|RAB3GAP1_ENST00000539493.1_Missense_Mutation_p.A704P	NM_012233.2	NP_036365.1	Q15042	RB3GP_HUMAN	RAB3 GTPase activating protein subunit 1 (catalytic)	748						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32				BRCA - Breast invasive adenocarcinoma(221;0.117)		GCCAATTCCTGCTAGAAGGCA	0.428000													3	40					0	0	0.000248	0	0
TMEM2	23670	broad.mit.edu	37	9	74364964	74364964	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:74364964G>A	ENST00000377044.4	-	2	865	c.326C>T	c.(325-327)cCa>cTa	p.P109L	TMEM2_ENST00000377066.5_Missense_Mutation_p.P109L	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	109						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		CTTACCATCTGGAGCATATTT	0.299000													15	25					0	0	0.006122	0	0
IQSEC3	440073	broad.mit.edu	37	12	266807	266807	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:266807A>G	ENST00000538872.1	+	7	2508	c.2390A>G	c.(2389-2391)aAc>aGc	p.N797S	IQSEC3_ENST00000382841.2_Missense_Mutation_p.N494S|IQSEC3_ENST00000326261.4_Missense_Mutation_p.N797S			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	797	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TACAGCCCCAACATCAAGCCT	0.587000													30	83					0	0	0.001706	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101572687	101572687	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:101572687C>T	ENST00000310954.6	-	13	2336	c.2050G>A	c.(2050-2052)Gga>Aga	p.G684R		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	684					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		ATTGCAAATCCATTGAAGAAC	0.308000													30	16					0	0	0.001271	0	0
ABCB11	8647	broad.mit.edu	37	2	169788943	169788943	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:169788943G>A	ENST00000263817.6	-	24	3281	c.3157C>T	c.(3157-3159)Caa>Taa	p.Q1053*		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1053					bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	TCCAGCAGTTGAAAAAAGCGT	0.433000													7	12					0	0	0.003080	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110439318	110439318	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:110439318G>A	ENST00000378402.5	+	25	3037	c.2933G>A	c.(2932-2934)gGa>gAa	p.G978E		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	978					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACACGAGAGGGAACCTGTGCT	0.527000										HNSCC(38;0.096)			91	68					0	0	0.003610	0	0
PSG8	440533	broad.mit.edu	37	19	43262198	43262198	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:43262198G>T	ENST00000404209.4	-	3	761	c.665C>A	c.(664-666)cCa>cAa	p.P222Q	PSG8_ENST00000406636.3_Missense_Mutation_p.P100Q|PSG8_ENST00000401467.2_Intron|PSG8_ENST00000306511.4_Missense_Mutation_p.P222Q|PSG8_ENST00000600709.1_5'UTR	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	222	Ig-like C2-type 1.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				GGCACTCACTGGGTTCCGTAT	0.507000													111	235					8.58103e-55	2.06313e-54	0.003610	1	0
TNR	7143	broad.mit.edu	37	1	175365882	175365882	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:175365882C>T	ENST00000367674.1	-	5	1746	c.1038G>A	c.(1036-1038)tgG>tgA	p.W346*	TNR_ENST00000263525.2_Nonsense_Mutation_p.W346*	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	346	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TCGGCCCGTCCCATTCCAGCT	0.607000													84	100					0	0	0.003610	0	0
CYP3A43	64816	broad.mit.edu	37	7	99453298	99453298	+	Missense_Mutation	SNP	C	C	T	rs140807333		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:99453298C>T	ENST00000354829.2	+	8	858	c.755C>T	c.(754-756)tCc>tTc	p.S252F	CYP3A43_ENST00000417625.1_Missense_Mutation_p.S142F|CYP3A43_ENST00000342499.4_Intron|CYP3A43_ENST00000312017.5_Missense_Mutation_p.S252F|CYP3A43_ENST00000444905.1_Intron|CYP3A43_ENST00000477658.1_3'UTR|CYP3A43_ENST00000222382.5_Missense_Mutation_p.S252F|CYP3A43_ENST00000415413.1_Intron	NM_022820.3|NM_057095.1	NP_073731.1|NP_476436.1	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 43	252			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	TTAAAAAATTCCATTGAAAGG	0.323000													11	45					0	0	0.000978	0	0
IL36RN	26525	broad.mit.edu	37	2	113819797	113819797	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:113819797G>A	ENST00000393200.2	+	4	373	c.212G>A	c.(211-213)gGg>gAg	p.G71E	IL36RN_ENST00000346807.3_Missense_Mutation_p.G71E	NM_012275.2	NP_036407.1	Q9UBH0	I36RA_HUMAN	interleukin 36 receptor antagonist	71						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						CTGTCATGTGGGGTGGGGCAG	0.622000													40	70					0	0	0.002852	0	0
AOX1	316	broad.mit.edu	37	2	201464374	201464374	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:201464374G>A	ENST00000374700.2	+	5	582	c.341G>A	c.(340-342)tGt>tAt	p.C114Y		NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	114					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GGCACCCAGTGTGGCTTCTGC	0.537000													14	55					0	0	0.004990	0	0
SPICE1	152185	broad.mit.edu	37	3	113186999	113186999	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:113186999C>T	ENST00000295872.4	-	10	1401	c.1142G>A	c.(1141-1143)cGg>cAg	p.R381Q		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	381					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						TTTAAGGTACCGAACCAGGCG	0.473000													25	78					0	0	0.001061	0	0
LDB1	8861	broad.mit.edu	37	10	103871231	103871231	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:103871231G>A	ENST00000425280.1	-	2	430	c.88C>T	c.(88-90)Ccc>Tcc	p.P30S	LDB1_ENST00000361198.5_5'UTR|LDB1_ENST00000490751.1_5'UTR	NM_001113407.1	NP_001106878.1	Q86U70	LDB1_HUMAN	LIM domain binding 1	30					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			breast(1)|central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)	21		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		TGGAAGGGGGGAAAGGCGTTG	0.572000													60	67					0	0	0.003610	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18715647	18715647	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:18715647G>A	ENST00000433979.1	+	26	3594	c.3478G>A	c.(3478-3480)Gaa>Aaa	p.E1160K	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.E1160K|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.E1201K	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1160	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				GAAAATAAAGGAAAGTCTGGA	0.373000													9	11					0	0	0.004482	0	0
DUOX1	53905	broad.mit.edu	37	15	45433532	45433532	+	Silent	SNP	C	C	A	rs141112574		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:45433532C>A	ENST00000321429.4	+	15	2015	c.1608C>A	c.(1606-1608)acC>acA	p.T536T	DUOX1_ENST00000561166.1_Silent_p.T182T|DUOX1_ENST00000389037.3_Silent_p.T536T	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	536	Peroxidase-like; mediates peroxidase activity.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		GAAATACCACCCTGCAGGACG	0.527000													36	37					6.05902e-23	1.44721e-22	0.003755	1	0
ARHGAP11A	9824	broad.mit.edu	37	15	32928921	32928921	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:32928921G>A	ENST00000361627.3	+	12	2669	c.1947G>A	c.(1945-1947)ttG>ttA	p.L649L	ARHGAP11A_ENST00000565905.1_Silent_p.L460L|ARHGAP11A_ENST00000543522.1_Silent_p.L460L	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	649					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		CTAATGATTTGACTATAGTAG	0.343000													17	10					0	0	0.004007	0	0
TNS3	64759	broad.mit.edu	37	7	47479085	47479085	+	Splice_Site	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:47479085C>T	ENST00000398879.1	-	6	516	c.150_splice	c.e6+1	p.L50_splice	TNS3_ENST00000458317.2_Splice_Site_p.L50_splice|TNS3_ENST00000442536.2_Splice_Site_p.L50_splice|TNS3_ENST00000355730.3_Splice_Site_p.L50_splice|TNS3_ENST00000311160.9_Splice_Site_p.L50_splice			Q68CZ2	TENS3_HUMAN	tensin 3	50	Phosphatase tensin-type.					focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						CACCGCTCACCAGGTAGTTGT	0.602000													25	16					0	0	0.005443	0	0
PPM1L	151742	broad.mit.edu	37	3	160474483	160474483	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:160474483G>A	ENST00000498165.1	+	1	488	c.387G>A	c.(385-387)ggG>ggA	p.G129G	PPM1L_ENST00000497343.1_Silent_p.G129G	NM_139245.2	NP_640338.2	Q5SGD2	PPM1L_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1L	129	PP2C-like.				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			TCTTCGACGGGCACGGGGGAG	0.562000													19	50					0	0	0.001523	0	0
TAB1	10454	broad.mit.edu	37	22	39815629	39815629	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:39815629T>G	ENST00000216160.6	+	7	832	c.770T>G	c.(769-771)cTt>cGt	p.L257R	TAB1_ENST00000331454.3_Missense_Mutation_p.L257R	NM_006116.2	NP_006107.1	Q15750	TAB1_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 1	257	PP2C-like.				activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|urinary_tract(1)	14						GACATTGACCTTCTCAGGTAG	0.557000													40	92					0	0	0.001287	0	0
MDM4	4194	broad.mit.edu	37	1	204501329	204501329	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:204501329G>A	ENST00000367182.3	+	5	460	c.298G>A	c.(298-300)Gat>Aat	p.D100N	MDM4_ENST00000367183.3_Intron|MDM4_ENST00000367180.1_Missense_Mutation_p.D100N|MDM4_ENST00000454264.2_Missense_Mutation_p.D100N|MDM4_ENST00000391947.2_Missense_Mutation_p.D100N|MDM4_ENST00000507825.2_Missense_Mutation_p.D100N|MDM4_ENST00000463049.1_3'UTR	NM_001204171.1|NM_001278516.1|NM_001278517.1|NM_001278518.1|NM_001278519.1|NM_002393.4	NP_001191100.1|NP_001265445.1|NP_001265446.1|NP_001265447.1|NP_001265448.1|NP_002384.2	O15151	MDM4_HUMAN	Mdm4 p53 binding protein homolog (mouse)	100	SWIB.				apoptosis|cell proliferation|cellular response to hypoxia|G0 to G1 transition|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of protein catabolic process|negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization	nucleus	enzyme binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	16	all_cancers(21;0.00146)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.112)|all_epithelial(62;0.118)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;3.15e-47)|all cancers(3;3.56e-32)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|Epithelial(59;0.143)|BRCA - Breast invasive adenocarcinoma(75;0.143)			CCCTCTCTATGATATGCTAAG	0.368000			A		"""GBM, bladder, retinoblastoma"""								26	87					0	0	0.001061	0	0
VCAM1	7412	broad.mit.edu	37	1	101186071	101186071	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:101186071A>C	ENST00000294728.2	+	2	205	c.104A>C	c.(103-105)tAt>tCt	p.Y35S	VCAM1_ENST00000370119.4_Missense_Mutation_p.Y35S|VCAM1_ENST00000347652.2_Missense_Mutation_p.Y35S|VCAM1_ENST00000370115.1_Missense_Mutation_p.Y35S	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	35	Ig-like C2-type 1.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GAATCTAGATATCTTGCTCAG	0.428000													35	56					0	0	0.002522	0	0
PLAT	5327	broad.mit.edu	37	8	42048910	42048910	+	Missense_Mutation	SNP	C	C	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:42048910C>G	ENST00000220809.4	-	3	351	c.95G>C	c.(94-96)aGa>aCa	p.R32T	PLAT_ENST00000429089.2_Missense_Mutation_p.R32T|PLAT_ENST00000352041.3_Missense_Mutation_p.R32T|PLAT_ENST00000270189.6_Missense_Mutation_p.R32T|PLAT_ENST00000524009.1_Missense_Mutation_p.R32T|PLAT_ENST00000429710.2_Missense_Mutation_p.R32T|PLAT_ENST00000519510.1_Missense_Mutation_p.R32T	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	32					blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TCTGGCTCCTCTTCTGAATCG	0.592000													37	107					0	0	0.001485	0	0
WDR17	116966	broad.mit.edu	37	4	177056383	177056383	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:177056383C>T	ENST00000393643.2	+	8	1475	c.1223C>T	c.(1222-1224)tCc>tTc	p.S408F	WDR17_ENST00000280190.4_Missense_Mutation_p.S432F|WDR17_ENST00000507824.2_Missense_Mutation_p.S415F|WDR17_ENST00000508596.1_Missense_Mutation_p.S408F	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	432										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		GTGTACACATCCCCGGGTAAT	0.348000													24	49					0	0	0.004656	0	0
SNHG12	85028	broad.mit.edu	37	1	28905159	28905159	+	RNA	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:28905159G>A	ENST00000488745.1	-	0	1258				SNHG12_ENST00000483436.1_RNA|SNHG12_ENST00000475441.1_RNA|SNHG12_ENST00000531126.1_RNA																							AAAATGACCGGGGTCCTTGCC	0.408000													22	46					0	0	0.001523	0	0
DYSF	8291	broad.mit.edu	37	2	71825792	71825792	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:71825792G>A	ENST00000258104.3	+	33	3896	c.3619G>A	c.(3619-3621)Gag>Aag	p.E1207K	DYSF_ENST00000410041.1_Missense_Mutation_p.E1225K|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000394120.2_Missense_Mutation_p.E1208K|DYSF_ENST00000429174.2_Missense_Mutation_p.E1207K|DYSF_ENST00000413539.2_Missense_Mutation_p.E1238K|DYSF_ENST00000409744.1_Missense_Mutation_p.E1194K|DYSF_ENST00000409762.1_Missense_Mutation_p.E1224K|DYSF_ENST00000410020.3_Missense_Mutation_p.E1225K|DYSF_ENST00000409651.1_Missense_Mutation_p.E1239K|DYSF_ENST00000409366.1_Missense_Mutation_p.E1208K|DYSF_ENST00000409582.3_Missense_Mutation_p.E1224K	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1207	C2 4.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CATCTTCTACGAGATCGAGAT	0.567000													19	58					0	0	0.000958	0	0
PTGFR	5737	broad.mit.edu	37	1	78959094	78959094	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:78959094C>T	ENST00000370756.3	+	2	903	c.666C>T	c.(664-666)atC>atT	p.I222I	PTGFR_ENST00000370757.3_Silent_p.I222I|PTGFR_ENST00000370758.1_Silent_p.I222I	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	222					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity	p.I222I(2)		breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	GCAATGCAATCACAGGAATTA	0.383000													35	66					0	0	0.005524	0	0
ATP13A4	84239	broad.mit.edu	37	3	193132506	193132506	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:193132506G>A	ENST00000342695.4	-	26	3198	c.2876C>T	c.(2875-2877)cCt>cTt	p.P959L	ATP13A4_ENST00000392443.3_Missense_Mutation_p.P940L|ATP13A4_ENST00000400270.2_5'UTR	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	959					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		AGGTCTGAAAGGCACCAGCTT	0.428000													13	32					0	0	0.001855	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800994	185800994	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:185800994G>C	ENST00000302277.6	+	4	1465	c.871G>C	c.(871-873)Gtt>Ctt	p.V291L		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	291						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						CAAAGAAACTGTTCAAACTCA	0.353000													8	18					0	0	0.004482	0	0
SIRPB2	284759	broad.mit.edu	37	20	1460463	1460463	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:1460463G>A	ENST00000359801.3	-	2	369	c.333C>T	c.(331-333)tcC>tcT	p.S111S	SIRPB2_ENST00000444444.1_Intron|SIRPB2_ENST00000537284.1_Intron|SIRPB2_ENST00000381630.1_Intron	NM_001122962.1	NP_001116434.1	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2	111	Ig-like V-type 1.					integral to membrane				endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GGATATAGATGGAATAATCAC	0.448000													29	73					0	0	0.001271	0	0
SLC4A10	57282	broad.mit.edu	37	2	162751304	162751304	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:162751304G>A	ENST00000375514.5	+	11	1540	c.1253G>A	c.(1252-1254)cGa>cAa	p.R418Q	SLC4A10_ENST00000421911.1_Missense_Mutation_p.R437Q|SLC4A10_ENST00000415876.2_Missense_Mutation_p.R407Q|SLC4A10_ENST00000535165.1_Missense_Mutation_p.E408K|SLC4A10_ENST00000272716.5_Missense_Mutation_p.R407Q|SLC4A10_ENST00000493021.1_3'UTR|SLC4A10_ENST00000446997.1_Missense_Mutation_p.R437Q	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	437					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						CCAAGCATTCGAATAGAGCCT	0.353000													11	38					0	0	0.002450	0	0
SERPINB3	6317	broad.mit.edu	37	18	61326656	61326656	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr18:61326656C>T	ENST00000283752.5	-	4	471	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	SERPINB3_ENST00000332821.8_Missense_Mutation_p.E110K|SERPINB11_ENST00000489748.1_RNA	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	110					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						TACGTTTTTTCTCCGAAGAGC	0.413000													30	65					0	0	0.003271	0	0
TTN	7273	broad.mit.edu	37	2	179615440	179615440	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:179615440G>T	ENST00000360870.5	-	46	11909	c.11687C>A	c.(11686-11688)gCt>gAt	p.A3896D	TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9720							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTTCACTAGCTATTTCTTC	0.353000													8	14					0.00307968	0.00723725	0.003080	1	0
FAM86DP	692099	broad.mit.edu	37	3	75475607	75475607	+	RNA	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:75475607C>T	ENST00000459803.1	-	0	922					NR_024241.1																						TCACCTAGCTCGGTGGTGAAC	0.652000													5	105					0	0	0.001168	0	0
CX3CR1	1524	broad.mit.edu	37	3	39323131	39323131	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:39323131G>A	ENST00000358309.3	-	1	95	c.56C>T	c.(55-57)tCt>tTt	p.S19F		NM_001171174.1	NP_001164645.1	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	0					cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		agaagccagagagctcttcct	0.552000													6	29					0	0	0.001984	0	0
MYH15	22989	broad.mit.edu	37	3	108129629	108129629	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:108129629G>A	ENST00000273353.3	-	32	4412	c.4356C>T	c.(4354-4356)gcC>gcT	p.A1452A		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1452						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GGTCCAGCCTGGCTGCTGCAG	0.632000													9	30					0	0	0.000443	0	0
ARSA	410	broad.mit.edu	37	22	51065636	51065636	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:51065636C>T	ENST00000547307.1	-	2	822	c.417G>A	c.(415-417)caG>caA	p.Q139Q	ARSA_ENST00000547805.1_Silent_p.Q139Q|ARSA_ENST00000453344.2_Silent_p.Q55Q|ARSA_ENST00000395621.3_Silent_p.Q141Q|ARSA_ENST00000356098.5_Silent_p.Q141Q|ARSA_ENST00000216124.5_Silent_p.Q141Q|ARSA_ENST00000395619.3_Silent_p.Q141Q			P15289	ARSA_HUMAN	arylsulfatase A	139						lysosome	arylsulfatase activity|calcium ion binding|cerebroside-sulfatase activity			endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|skin(1)	9		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)	Micafungin(DB01141)	GATGGAAGCCCTGATGGGGGG	0.672000													9	44					0	0	0.004482	0	0
DNAH9	1770	broad.mit.edu	37	17	11593556	11593556	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:11593556G>A	ENST00000262442.3	+	20	4485	c.4417G>A	c.(4417-4419)Gag>Aag	p.E1473K	DNAH9_ENST00000454412.2_Missense_Mutation_p.E1473K	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1473	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGAGGTTCTGGAGGATAATCA	0.532000													28	61					0	0	0.001061	0	0
SCD	6319	broad.mit.edu	37	10	102107993	102107993	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:102107993C>T	ENST00000370355.2	+	2	581	c.200C>T	c.(199-201)cCc>cTc	p.P67L		NM_005063.4	NP_005054.3	O00767	ACOD_HUMAN	stearoyl-CoA desaturase (delta-9-desaturase)	67					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			endometrium(1)|large_intestine(3)|lung(5)	9		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		GGCCCAAGCCCCAAGGTTGAA	0.463000													61	113					0	0	0.003610	0	0
RIMBP3	85376	broad.mit.edu	37	22	20457978	20457978	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:20457978G>A	ENST00000426804.1	-	1	3808	c.3324C>T	c.(3322-3324)ctC>ctT	p.L1108L		NM_015672.1	NP_056487.1			RIMS binding protein 3											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	13	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			TGGTCACAGGGAGCCAGCTGA	0.602000													4	24					0	0	0.000602	0	0
RB1	5925	broad.mit.edu	37	13	48955550	48955550	+	Nonsense_Mutation	SNP	C	C	T	rs121913304		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr13:48955550C>T	ENST00000267163.4	+	17	1804	c.1666C>T	c.(1666-1668)Cga>Tga	p.R556*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	556	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(8)|p.R556*(5)|p.C553fs*53(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATGTGAACATCGAATCATGGA	0.333000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			38	12					0	0	0.001287	0	0
SP7	121340	broad.mit.edu	37	12	53721980	53721980	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:53721980C>T	ENST00000536324.2	-	3	1529	c.1246G>A	c.(1246-1248)Gag>Aag	p.E416K	SP7_ENST00000303846.3_Missense_Mutation_p.E416K|SP7_ENST00000537210.2_Missense_Mutation_p.E398K	NM_001173467.1	NP_001166938.1	Q8TDD2	SP7_HUMAN	Sp7 transcription factor	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	14						GGGGCTTTCTCTGGGGTTGCT	0.677000											OREG0021867	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	34					0	0	0.003163	0	0
ITGB1	3688	broad.mit.edu	37	10	33217122	33217122	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:33217122C>A	ENST00000396033.2	-	5	582	c.447G>T	c.(445-447)atG>atT	p.M149I	ITGB1_ENST00000423113.1_Missense_Mutation_p.M149I|ITGB1_ENST00000374956.4_Missense_Mutation_p.M149I|ITGB1_ENST00000302278.3_Missense_Mutation_p.M149I|ITGB1_ENST00000484088.1_Intron	NM_133376.2	NP_596867.1	P05556	ITB1_HUMAN	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	149	VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Ovarian(717;1.34e-05)|Breast(68;0.0634)				AAGACAGGTCCATAAGGTAGT	0.373000													64	28					4.60343e-24	1.10135e-23	0.003610	1	0
ADH1C	126	broad.mit.edu	37	4	100260761	100260761	+	RNA	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:100260761C>T	ENST00000515683.1	-	0	1427					NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	CAGGTCAAATCCTTCATTTAT	0.393000													18	25					0	0	0.004990	0	0
DMXL1	1657	broad.mit.edu	37	5	118485077	118485077	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:118485077C>T	ENST00000311085.8	+	18	3635	c.3555C>T	c.(3553-3555)ctC>ctT	p.L1185L	DMXL1_ENST00000539542.1_Silent_p.L1185L	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1185										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CATTTCCTCTCTGGGAGAGTA	0.438000													55	29					0	0	0.003610	0	0
SMAD3	4088	broad.mit.edu	37	15	67473595	67473595	+	Silent	SNP	C	C	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:67473595C>G	ENST00000327367.4	+	6	985	c.675C>G	c.(673-675)acC>acG	p.T225T	SMAD3_ENST00000540846.2_Silent_p.T120T|SMAD3_ENST00000537194.2_Silent_p.T30T|SMAD3_ENST00000439724.3_Silent_p.T181T	NM_005902.3	NP_005893.1	P84022	SMAD3_HUMAN	SMAD family member 3	225	Linker.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(11)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		AGCCAGTTACCTACTGCGAGC	0.607000													6	33					0	0	0.001984	0	0
APOB	338	broad.mit.edu	37	2	21235191	21235191	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:21235191C>T	ENST00000233242.1	-	26	4676	c.4549G>A	c.(4549-4551)Gag>Aag	p.E1517K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1517					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGGTTGGACTCTCCATTGAGC	0.498000													92	322					0	0	0.003610	0	0
UNC13C	440279	broad.mit.edu	37	15	54305645	54305645	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:54305645G>A	ENST00000545554.1	+	1	545	c.545G>A	c.(544-546)cGa>cAa	p.R182Q	UNC13C_ENST00000537900.1_Missense_Mutation_p.R182Q|UNC13C_ENST00000260323.11_Missense_Mutation_p.R182Q			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	182					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding	p.R182Q(1)		breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGAGCTTTACGAAAACTGAGA	0.458000													72	29					0	0	0.003610	0	0
DNAH11	8701	broad.mit.edu	37	7	21775406	21775406	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:21775406A>G	ENST00000328843.6	+	47	7641	c.7610A>G	c.(7609-7611)gAt>gGt	p.D2537G	DNAH11_ENST00000409508.3_Missense_Mutation_p.D2530G			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2537	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CTCTCTGAGGATTACATAGTA	0.418000									Kartagener syndrome				88	62					0	0	0.003610	0	0
ABO	28	broad.mit.edu	37	9	136131067	136131067	+	RNA	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:136131067C>T	ENST00000453660.2	-	0	1061							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		GGGTTCCGGACCGCCTGGTGG	0.672000													8	8					0	0	0.004482	0	0
RALBP1	10928	broad.mit.edu	37	18	9524620	9524620	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr18:9524620T>A	ENST00000019317.4	+	5	1305	c.1082T>A	c.(1081-1083)tTc>tAc	p.F361Y	RALBP1_ENST00000383432.3_Missense_Mutation_p.F361Y			Q15311	RBP1_HUMAN	ralA binding protein 1	361	Rho-GAP.				chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(3)|upper_aerodigestive_tract(1)	14						TATGTGTTTTTCACACATGTG	0.383000													10	42					0	0	0.001368	0	0
COL11A2	1302	broad.mit.edu	37	6	33139493	33139493	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:33139493G>A	ENST00000341947.2	-	42	3374	c.3147C>T	c.(3145-3147)gtC>gtT	p.V1049V	COL11A2_ENST00000395197.1_Silent_p.V989V|COL11A2_ENST00000357486.1_Silent_p.V1028V|COL11A2_ENST00000361917.1_Silent_p.V942V|COL11A2_ENST00000374708.4_Silent_p.V963V|COL11A2_ENST00000374712.1_Silent_p.V968V|COL11A2_ENST00000374714.1_Silent_p.V1023V|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000374713.1_Silent_p.V1002V	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1049	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CACTCACTGGGACACCTTTCT	0.642000													11	24					0	0	0.001855	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227239624	227239624	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:227239624C>T	ENST00000366766.2	-	22	3909	c.2967G>A	c.(2965-2967)cgG>cgA	p.R989R	CDC42BPA_ENST00000334218.5_Intron|CDC42BPA_ENST00000366767.3_Intron|CDC42BPA_ENST00000366765.3_Intron|CDC42BPA_ENST00000366769.3_Intron|CDC42BPA_ENST00000535525.1_Intron|CDC42BPA_ENST00000366764.2_Intron			Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	968					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				GAGATGTGGACCGTGACTGGA	0.448000													23	100					0	0	0.004656	0	0
ABCB11	8647	broad.mit.edu	37	2	169783734	169783734	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:169783734G>A	ENST00000263817.6	-	26	3674	c.3550C>T	c.(3550-3552)Ccc>Tcc	p.P1184S		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1184	ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTTTCCATGGGAATTTCTTTG	0.453000													29	106					0	0	0.001512	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254505	30254505	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chrX:30254505A>T	ENST00000361644.2	+	5	1201	c.464A>T	c.(463-465)aAa>aTa	p.K155I	MAGEB3_ENST00000378986.1_Missense_Mutation_p.K155I	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	155	MAGE.									NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						ATCCTTAAAAAAGCTTCTTTC	0.373000													39	8					0	0	0.005524	0	0
ABLIM1	3983	broad.mit.edu	37	10	116251619	116251619	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:116251619G>A	ENST00000533213.2	-	7	1034	c.733C>T	c.(733-735)Cac>Tac	p.H245Y	ABLIM1_ENST00000277895.5_Missense_Mutation_p.H305Y|ABLIM1_ENST00000369253.2_5'UTR|ABLIM1_ENST00000392952.3_5'UTR|ABLIM1_ENST00000369266.3_5'UTR|ABLIM1_ENST00000369252.4_Missense_Mutation_p.H245Y			O14639	ABLM1_HUMAN	actin binding LIM protein 1	305	LIM zinc-binding 3.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		CAGCTGGGGTGGTAATGTTTG	0.453000													78	124					0	0	0.003610	0	0
GIMAP8	155038	broad.mit.edu	37	7	150164383	150164383	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:150164383C>T	ENST00000307271.3	+	2	1171	c.597C>T	c.(595-597)ccC>ccT	p.P199P		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	199						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		ACGGAGGACCCTATCATGTGA	0.418000													37	57					0	0	0.005524	0	0
LILRB1	10859	broad.mit.edu	37	19	55143159	55143159	+	Silent	SNP	A	A	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:55143159A>G	ENST00000396331.1	+	5	636	c.279A>G	c.(277-279)gcA>gcG	p.A93A	LILRB1_ENST00000418536.2_Silent_p.A93A|LILRB1_ENST00000427581.2_Silent_p.A129A|LILRB1_ENST00000396327.3_Silent_p.A93A|LILRB1_ENST00000448689.1_Silent_p.A93A|LILRB1_ENST00000434867.2_Silent_p.A93A|LILRB1_ENST00000396332.4_Silent_p.A93A|LILRB1_ENST00000396315.1_Silent_p.A93A|LILRB1_ENST00000324602.7_Silent_p.A93A|LILRB1_ENST00000396321.2_Silent_p.A93A|LILRB1_ENST00000396317.1_Silent_p.A93A	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	93	Ig-like C2-type 1.		A -> T (in dbSNP:rs12460501).		regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GGGAACATGCAGGGCGGTATC	0.552000										HNSCC(37;0.09)			32	67					0	0	0.002445	0	0
PCSK5	5125	broad.mit.edu	37	9	78953217	78953217	+	Missense_Mutation	SNP	G	G	A	rs145485084	by1000genomes	TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:78953217G>A	ENST00000545128.1	+	34	5277	c.4739G>A	c.(4738-4740)cGg>cAg	p.R1580Q		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	751					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						CAGGGCCCACGGCCCACAGAC	0.527000													18	22					0	0	0.001216	0	0
ZNF71	58491	broad.mit.edu	37	19	57133977	57133977	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:57133977G>A	ENST00000328070.6	+	3	1556	c.1322G>A	c.(1321-1323)gGc>gAc	p.G441D		NM_021216.4	NP_067039.1	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	441						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		TACAGGTGCGGCCAGTGCGGG	0.647000													13	35					0	0	0.001368	0	0
XPO5	57510	broad.mit.edu	37	6	43494440	43494440	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:43494440G>A	ENST00000265351.7	-	27	3176	c.2966C>T	c.(2965-2967)cCc>cTc	p.P989L	POLR1C_ENST00000304004.3_Intron	NM_020750.2	NP_065801.1	Q9HAV4	XPO5_HUMAN	exportin 5	989					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(4)|lung(10)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	34	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			ATCTGCTGGGGGAGCACTACT	0.493000													11	33					0	0	0.001368	0	0
CD58	965	broad.mit.edu	37	1	117064556	117064556	+	Silent	SNP	A	A	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:117064556A>T	ENST00000457047.2	-	4	731	c.678T>A	c.(676-678)atT>atA	p.I226I	CD58_ENST00000369487.3_Silent_p.I226I|CD58_ENST00000369489.5_Silent_p.I226I	NM_001144822.1	NP_001138294.1	P19256	LFA3_HUMAN	CD58 molecule	226					blood coagulation|cell-cell adhesion|leukocyte migration	anchored to membrane|integral to plasma membrane	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(3)|urinary_tract(1)	9	Lung SC(450;0.225)	all_cancers(81;0.000363)|all_lung(203;0.000118)|all_epithelial(167;0.000149)|Lung NSC(69;0.000577)		Lung(183;0.0086)|LUSC - Lung squamous cell carcinoma(189;0.0528)|Colorectal(144;0.0775)|all cancers(265;0.109)|Epithelial(280;0.118)|COAD - Colon adenocarcinoma(174;0.121)		TACATGTTGTAATTACTGCTA	0.294000													7	11					0	0	0.003080	0	0
BTN1A1	696	broad.mit.edu	37	6	26505398	26505398	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:26505398C>T	ENST00000244513.6	+	3	739	c.673C>T	c.(673-675)Ctt>Ttt	p.L225F		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	225	Ig-like V-type 2.					extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						GAATCTCCTTCTTGGCCAGGA	0.468000													50	77					0	0	0.003610	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37465275	37465275	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:37465275G>A	ENST00000381792.2	-	16	2091	c.1951C>T	c.(1951-1953)Cac>Tac	p.H651Y	TMPRSS6_ENST00000406856.1_Missense_Mutation_p.H651Y|TMPRSS6_ENST00000346753.3_Missense_Mutation_p.H660Y|TMPRSS6_ENST00000406725.1_Missense_Mutation_p.H651Y			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	660	Peptidase S1.				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						TCCTCTTCGTGGTACGGGTGC	0.692000													7	26					0	0	0.003080	0	0
ZCCHC4	29063	broad.mit.edu	37	4	25366777	25366777	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:25366777G>A	ENST00000302874.4	+	12	1419	c.1395G>A	c.(1393-1395)aaG>aaA	p.K465K		NM_024936.2	NP_079212.2	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	465							methyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)	9		Breast(46;0.0503)				CTACATCTAAGAGAGCTAACA	0.393000													21	62					0	0	0.002780	0	0
MZF1	7593	broad.mit.edu	37	19	59081864	59081864	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:59081864G>A	ENST00000215057.2	-	3	987	c.427C>T	c.(427-429)Cta>Tta	p.L143L	AC016629.8_ENST00000593642.1_RNA|MZF1_ENST00000599369.1_Silent_p.L143L|MZF1_ENST00000594234.1_Silent_p.L143L|AC016629.8_ENST00000600726.1_RNA|AC016629.8_ENST00000600534.1_RNA|MZF1_ENST00000594108.1_Silent_p.L143L	NM_001267033.1|NM_198055.1	NP_001253962.1|NP_932172.1	P28698	MZF1_HUMAN	myeloid zinc finger 1	143					viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.L143V(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		TTCTCTGATAGGACCTCCTGG	0.602000													15	26					0	0	0.004007	0	0
ALOX12	239	broad.mit.edu	37	17	6903691	6903691	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:6903691G>A	ENST00000251535.6	+	7	897	c.844G>A	c.(844-846)Gat>Aat	p.D282N	AC027763.2_ENST00000575727.1_Intron|AC027763.2_ENST00000574377.1_Intron|RP11-589P10.7_ENST00000572547.1_RNA|AC027763.2_ENST00000399541.2_Intron	NM_000697.2	NP_000688.2	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	282	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)|urinary_tract(1)	19						CATCCTTCTGGATGGAATTCC	0.542000													40	148					0	0	0.001485	0	0
OR14C36	127066	broad.mit.edu	37	1	248512748	248512748	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:248512748C>T	ENST00000317861.1	+	1	672	c.672C>T	c.(670-672)ctC>ctT	p.L224L		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	224					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L224L(1)		central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						CGACCGTGCTCGGGTTTCCAA	0.498000													28	104					0	0	0.004656	0	0
ZNF536	9745	broad.mit.edu	37	19	31039935	31039935	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:31039935G>A	ENST00000355537.3	+	4	3556	c.3409G>A	c.(3409-3411)Gga>Aga	p.G1137R		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGAGCCTGATGGAAAGGCCCA	0.517000													32	31					0	0	0.002445	0	0
SLIT1	6585	broad.mit.edu	37	10	98816191	98816191	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:98816191G>A	ENST00000266058.4	-	13	1433	c.1188C>T	c.(1186-1188)atC>atT	p.I396I	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Silent_p.I396I	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	396					axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		CATCGGGCCGGATGCAGTTGA	0.597000													59	156					0	0	0.003610	0	0
ZNF835	90485	broad.mit.edu	37	19	57176307	57176307	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:57176307C>T	ENST00000537055.2	-	2	491	c.260G>A	c.(259-261)gGg>gAg	p.G87E		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						CGGGCTCTCCCCAGGCGCGCT	0.647000													19	44					0	0	0.001216	0	0
GAS2L2	246176	broad.mit.edu	37	17	34072033	34072033	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:34072033G>A	ENST00000254466.6	-	6	2510	c.2483C>T	c.(2482-2484)tCc>tTc	p.S828F	GAS2L2_ENST00000587565.1_Missense_Mutation_p.S812F	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	828					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ATCCACCCGGGATGCCTCCCC	0.637000													43	62					0	0	0.003610	0	0
PCDHB16	57717	broad.mit.edu	37	5	140562300	140562300	+	Silent	SNP	T	T	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:140562300T>C	ENST00000361016.2	+	1	1321	c.166T>C	c.(166-168)Ttg>Ctg	p.L56L		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		56	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGGTTGGGGTTGACAGAGAT	0.527000													111	42					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179590745	179590745	+	Silent	SNP	A	A	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:179590745A>G	ENST00000589042.1	-	70	20528	c.20304T>C	c.(20302-20304)ccT>ccC	p.P6768P	TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Silent_p.P6451P|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|RP11-171I2.1_ENST00000590024.1_RNA|TTN_ENST00000342992.6_Silent_p.P5524P	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6451	Ig-like 49.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTACTATAGGAGGGAAGC	0.383000													11	35					0	0	0.001368	0	0
ELTD1	64123	broad.mit.edu	37	1	79470895	79470895	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:79470895G>A	ENST00000370742.3	-	2	95	c.32C>T	c.(31-33)tCc>tTc	p.S11F		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	11					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity	p.S11F(1)		NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		CAACAAAGTGGAAAAAACCAC	0.323000													8	17					0	0	0.003080	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3674142	3674142	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:3674142G>A	ENST00000344754.4	-	13	3459	c.3460C>T	c.(3460-3462)Cct>Tct	p.P1154S	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.P1154S	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1154	Ig-like C2-type 11.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GCCCGACCAGGGGGGCCCACA	0.642000													32	51					0	0	0.002445	0	0
SEC16B	89866	broad.mit.edu	37	1	177899741	177899741	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:177899741A>C	ENST00000308284.6	-	25	3139	c.3050T>G	c.(3049-3051)cTt>cGt	p.L1017R	RP4-798P15.3_ENST00000528461.1_3'UTR|RP4-798P15.3_ENST00000354921.2_5'UTR|SEC16B_ENST00000495165.1_5'UTR	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	1017					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						TGGAGGAAGAAGAACACCAGG	0.542000													25	25					0	0	0.004656	0	0
FRMPD4	9758	broad.mit.edu	37	X	12736775	12736775	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chrX:12736775A>T	ENST00000380682.1	+	16	4336	c.3830A>T	c.(3829-3831)gAa>gTa	p.E1277V		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1277					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						ACCTTTAAGGAACTGCACCCA	0.542000													107	27					0	0	0.003610	0	0
TRBV6-6	28601	broad.mit.edu	37	7	142161996	142161996	+	RNA	SNP	G	G	A	rs55663062		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:142161996G>A	ENST00000390371.3	-	0	322																											GCCTGAGCGGGAAATACTCTG	0.502000													170	170					0	0	0.003610	0	0
BCAS2	10286	broad.mit.edu	37	1	115123994	115123994	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:115123994C>T	ENST00000369541.3	-	2	159	c.112G>A	c.(112-114)Gag>Aag	p.E38K	BCAS2_ENST00000485021.1_5'UTR	NM_005872.2	NP_005863.1	O75934	SPF27_HUMAN	breast carcinoma amplified sequence 2	38					mRNA processing|RNA splicing, via transesterification reactions	nucleolus|spliceosomal complex	protein binding			biliary_tract(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)	13	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGAGTTTCCTCCTCCACCAGC	0.493000													93	136					0	0	0.003610	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227239625	227239625	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:227239625C>T	ENST00000366766.2	-	22	3908	c.2966G>A	c.(2965-2967)cGg>cAg	p.R989Q	CDC42BPA_ENST00000334218.5_Intron|CDC42BPA_ENST00000366767.3_Intron|CDC42BPA_ENST00000366765.3_Intron|CDC42BPA_ENST00000366769.3_Intron|CDC42BPA_ENST00000535525.1_Intron|CDC42BPA_ENST00000366764.2_Intron			Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	968					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				AGATGTGGACCGTGACTGGAT	0.448000													23	102					0	0	0.005443	0	0
C1orf94	84970	broad.mit.edu	37	1	34663513	34663513	+	Splice_Site	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:34663513G>A	ENST00000488417.1	+	2	1128	c.1009_splice	c.e2+1	p.M336_splice	C1orf94_ENST00000373374.3_Splice_Site_p.M146_splice	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	146							protein binding	p.M146I(1)		central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				ACCACTTGATGGGTGAGTGGG	0.572000													20	27					0	0	0.001882	0	0
KIAA1009	22832	broad.mit.edu	37	6	84894991	84894991	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:84894991G>A	ENST00000403245.3	-	13	1691	c.1577C>T	c.(1576-1578)tCt>tTt	p.S526F	KIAA1009_ENST00000461137.1_5'UTR|KIAA1009_ENST00000257766.4_Missense_Mutation_p.S450F	NM_014895.2	NP_055710.2	Q5TB80	QN1_HUMAN	KIAA1009	526					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		TTCAAGAGTAGAAAACATCTT	0.388000													54	59					0	0	0.003610	0	0
HEATR5B	54497	broad.mit.edu	37	2	37234429	37234429	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:37234429G>A	ENST00000233099.5	-	29	4636	c.4541C>T	c.(4540-4542)cCt>cTt	p.P1514L	HEATR5B_ENST00000354531.2_Missense_Mutation_p.P1514L	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1514							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				AATAGTTTCAGGGGTATAAAA	0.383000													21	68					0	0	0.003330	0	0
OR7E24	26648	broad.mit.edu	37	19	9362583	9362583	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:9362583G>A	ENST00000456448.1	+	1	978	c.864G>A	c.(862-864)aaG>aaA	p.K288K		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	288					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						CCCCCAGGAAGAGTATGGTGG	0.522000													14	32					0	0	0.003163	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3674141	3674141	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:3674141G>A	ENST00000344754.4	-	13	3460	c.3461C>T	c.(3460-3462)cCt>cTt	p.P1154L	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.P1154L	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1154	Ig-like C2-type 11.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						TGCCCGACCAGGGGGGCCCAC	0.647000													32	52					0	0	0.002445	0	0
COL27A1	85301	broad.mit.edu	37	9	117029817	117029817	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:117029817C>T	ENST00000356083.3	+	34	3872	c.3481C>T	c.(3481-3483)Cct>Tct	p.P1161S		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	1161	Collagen-like 9.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						ACCGGGCCTTCCTGGGGAAGC	0.562000													37	61					0	0	0.001706	0	0
EEF1B2	1933	broad.mit.edu	37	2	207024728	207024728	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:207024728C>T	ENST00000392222.2	+	1	400	c.25C>T	c.(25-27)Cct>Tct	p.P9S	EEF1B2_ENST00000236957.5_Missense_Mutation_p.P9S|EEF1B2_ENST00000392221.1_Missense_Mutation_p.P9S	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	9	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCTGAAAAGCCCTGCCGGCCT	0.632000													17	94					0	0	0.000958	0	0
AOC3	8639	broad.mit.edu	37	17	41003363	41003363	+	Translation_Start_Site	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:41003363G>A	ENST00000308423.2	+	1	163	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_003734.2	NP_003725.1	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3	1					amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			breast(1)|central_nervous_system(4)|endometrium(4)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|skin(8)	41		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	GTGGGAAAATGAACCAGAAGA	0.567000													37	114					0	0	0.001951	0	0
PNPLA7	375775	broad.mit.edu	37	9	140438180	140438180	+	Nonsense_Mutation	SNP	T	T	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:140438180T>A	ENST00000406427.1	-	5	697	c.361A>T	c.(361-363)Aag>Tag	p.K121*	PNPLA7_ENST00000277531.4_Nonsense_Mutation_p.K96*	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	96					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		CAGTACCTCTTGGCCAAAGAC	0.632000													34	63					0	0	0.003271	0	0
CLDN15	24146	broad.mit.edu	37	7	100876137	100876137	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:100876137G>A	ENST00000401528.1	-	4	1566	c.441C>T	c.(439-441)ttC>ttT	p.F147F	CLDN15_ENST00000308344.5_Silent_p.F147F	NM_001185080.1	NP_001172009.1	P56746	CLD15_HUMAN	claudin 15	147					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	10	Lung NSC(181;0.168)|all_lung(186;0.215)					ACAAGGGGTCGAAGAAGTCCC	0.682000													19	52					0	0	0.001523	0	0
AKAP11	11215	broad.mit.edu	37	13	42891698	42891698	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr13:42891698G>A	ENST00000025301.2	+	12	5614	c.5439G>A	c.(5437-5439)acG>acA	p.T1813T		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	1813					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TGCTAATTACGAATATTGACA	0.383000													67	15					0	0	0.003610	0	0
USP6NL	9712	broad.mit.edu	37	10	11505127	11505127	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:11505127G>A	ENST00000379237.1	-	15	2194	c.1800C>T	c.(1798-1800)tcC>tcT	p.S600S	USP6NL_ENST00000277575.5_Silent_p.S617S	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	600						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						TAAACTTGTTGGATACTTTTG	0.547000													19	14					0	0	0.006122	0	0
OR2AE1	81392	broad.mit.edu	37	7	99474579	99474579	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:99474579G>A	ENST00000316368.2	-	1	101	c.78C>T	c.(76-78)ttC>ttT	p.F26F		NM_001005276.1	NP_001005276.1	Q8NHA4	O2AE1_HUMAN	olfactory receptor, family 2, subfamily AE, member 1	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)	11	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					AGGAGAAAAGGAAAAGGTGGG	0.502000													59	60					0	0	0.003610	0	0
CACNA1D	776	broad.mit.edu	37	3	53845206	53845206	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:53845206G>A	ENST00000288139.3	+	49	6437	c.6319G>A	c.(6319-6321)Gaa>Aaa	p.E2107K	CACNA1D_ENST00000422281.2_Missense_Mutation_p.E2063K|CACNA1D_ENST00000544977.1_3'UTR|CACNA1D_ENST00000350061.5_Missense_Mutation_p.E2087K	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	2087					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	AACAAAACACGAAATCGCTGA	0.552000													23	67					0	0	0.002299	0	0
DAK	26007	broad.mit.edu	37	11	61113332	61113332	+	Missense_Mutation	SNP	G	G	A	rs34035740	byFrequency	TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:61113332G>A	ENST00000394900.3	+	17	1718	c.1489G>A	c.(1489-1491)Gat>Aat	p.D497N		NM_015533.3	NP_056348.2	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2 homolog (S. cerevisiae)	497	DhaL.			D -> G (in Ref. 2; BAB14722).	glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding			NS(1)|breast(3)|endometrium(3)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	23						TGTCCAGCTGGATTCTCTGTG	0.582000													33	40					0	0	0.002836	0	0
NBEA	26960	broad.mit.edu	37	13	36046604	36046604	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr13:36046604C>T	ENST00000540320.1	+	41	7050	c.6516C>T	c.(6514-6516)tcC>tcT	p.S2172S	NBEA_ENST00000400445.3_Silent_p.S2172S|NBEA_ENST00000379939.2_Silent_p.S2169S|NBEA_ENST00000310336.4_Silent_p.S2172S			Q8NFP9	NBEA_HUMAN	neurobeachin	2172						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GGACTCTCTCCATCACCACGA	0.537000													95	22					0	0	0.003610	0	0
NBEA	26960	broad.mit.edu	37	13	36046603	36046603	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr13:36046603C>T	ENST00000540320.1	+	41	7049	c.6515C>T	c.(6514-6516)tCc>tTc	p.S2172F	NBEA_ENST00000400445.3_Missense_Mutation_p.S2172F|NBEA_ENST00000379939.2_Missense_Mutation_p.S2169F|NBEA_ENST00000310336.4_Missense_Mutation_p.S2172F			Q8NFP9	NBEA_HUMAN	neurobeachin	2172						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GGGACTCTCTCCATCACCACG	0.537000													95	22					0	0	0.003610	0	0
TNNI1	7135	broad.mit.edu	37	1	201379534	201379534	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:201379534C>T	ENST00000361379.4	-	8	578	c.486G>A	c.(484-486)agG>agA	p.R162R	TNNI1_ENST00000367312.1_Silent_p.R162R|TNNI1_ENST00000555948.1_Intron|TNNI1_ENST00000336092.4_Silent_p.R162R	NM_003281.3	NP_003272.3	P19237	TNNI1_HUMAN	troponin I type 1 (skeletal, slow)	162					muscle filament sliding|regulation of striated muscle contraction	cytosol|troponin complex	actin binding|tropomyosin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	8						CCACGTTCTTCCTCCAGTCAC	0.587000													36	90					0	0	0.001706	0	0
ATP6V0A2	23545	broad.mit.edu	37	12	124232228	124232228	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:124232228C>T	ENST00000330342.3	+	14	1928	c.1680C>T	c.(1678-1680)atC>atT	p.I560I		NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	560					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		TTTTAGGAATCATTCATATGA	0.313000													29	21					0	0	0.005443	0	0
SDK1	221935	broad.mit.edu	37	7	4247870	4247870	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:4247870G>A	ENST00000404826.2	+	37	5493	c.5354G>A	c.(5353-5355)gGa>gAa	p.G1785E	SDK1_ENST00000389531.3_Missense_Mutation_p.G1765E	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1785	Fibronectin type-III 11.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AACGCCGCCGGAGATGGACCT	0.597000													17	56					0	0	0.001523	0	0
SAMD12	401474	broad.mit.edu	37	8	119391905	119391905	+	Silent	SNP	G	G	A	rs150265138	byFrequency	TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:119391905G>A	ENST00000409003.4	-	4	485	c.357C>T	c.(355-357)ctC>ctT	p.L119L	AC023590.1_ENST00000430457.1_Intron|SAMD12_ENST00000314727.4_Silent_p.L119L	NM_001101676.1	NP_001095146.1	Q8N8I0	SAM12_HUMAN	sterile alpha motif domain containing 12	119	SAM.									endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)	9	all_cancers(13;3.91e-25)|Lung NSC(37;1.13e-07)|Ovarian(258;0.0249)		STAD - Stomach adenocarcinoma(47;0.00391)			CCATTCGCTCGAGCTTTTTGT	0.463000													41	158					0	0	0.003610	0	0
NLRP5	126206	broad.mit.edu	37	19	56539808	56539808	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:56539808C>T	ENST00000390649.3	+	7	2209	c.2209C>T	c.(2209-2211)Cgg>Tgg	p.R737W		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	737						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GCGGAAAATTCGGGTGGATGT	0.498000													100	195					0	0	0.003610	0	0
GSTO1	9446	broad.mit.edu	37	10	106025864	106025864	+	Missense_Mutation	SNP	C	C	T	rs116993524	byFrequency	TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:106025864C>T	ENST00000539281.1	+	5	760	c.404C>T	c.(403-405)aCc>aTc	p.T135I	GSTO1_ENST00000493946.1_3'UTR|GSTO1_ENST00000369713.5_Missense_Mutation_p.T163I|GSTO1_ENST00000369710.4_Missense_Mutation_p.T130I	NM_001191003.1	NP_001177932.1	P78417	GSTO1_HUMAN	glutathione S-transferase omega 1	163	GST C-terminal.				xenobiotic metabolic process	cytosol	glutathione transferase activity|monodehydroascorbate reductase (NADH) activity			large_intestine(1)|lung(1)|stomach(1)	3		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;8.07e-10)|all cancers(201;2.72e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0147)	Glutathione(DB00143)	AAGAAGACGACCTTCTTTGGT	0.363000													31	102					0	0	0.002836	0	0
TXNL1	9352	broad.mit.edu	37	18	54291641	54291641	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr18:54291641G>A	ENST00000217515.6	-	3	451	c.247C>T	c.(247-249)Cga>Tga	p.R83*	TXNL1_ENST00000590954.1_Nonsense_Mutation_p.R83*|TXNL1_ENST00000540155.1_5'UTR	NM_004786.2	NP_004777.1	O43396	TXNL1_HUMAN	thioredoxin-like 1	83	Thioredoxin.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity			endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)		ACTTTGTTTCGAAAAAACAAA	0.373000													52	106					0	0	0.003610	0	0
MS4A10	341116	broad.mit.edu	37	11	60565890	60565890	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:60565890C>T	ENST00000308287.1	+	7	721	c.625C>T	c.(625-627)Ccg>Tcg	p.P209S		NM_206893.3	NP_996776.2	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member 10	209						integral to membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|skin(2)	21						ATGCCTTGTTCCGAATACACC	0.547000													33	22					0	0	0.002445	0	0
HLCS	3141	broad.mit.edu	37	21	38139568	38139568	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr21:38139568C>T	ENST00000399120.1	-	8	2700	c.1470G>A	c.(1468-1470)ccG>ccA	p.P490P	HLCS_ENST00000336648.3_Silent_p.P490P	NM_001242784.1	NP_001229713.1	P50747	BPL1_HUMAN	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	490					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding	p.P490P(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	CCATTTCCTGCGGTGTCTGAA	0.547000													26	65					0	0	0.004656	0	0
TOR1AIP2	163590	broad.mit.edu	37	1	179820352	179820352	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:179820352G>A	ENST00000367612.3	-	4	568	c.181C>T	c.(181-183)Cca>Tca	p.P61S		NM_001199260.1|NM_145034.4	NP_001186189.1|NP_659471.1	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	61						endoplasmic reticulum membrane|integral to membrane	protein binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(10)|ovary(1)|skin(2)	18						GCACTTTCTGGACCTTCTGTC	0.438000													33	148					0	0	0.004878	0	0
CLDN14	23562	broad.mit.edu	37	21	37833622	37833622	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr21:37833622G>A	ENST00000399137.1	-	3	1238	c.372C>T	c.(370-372)ctC>ctT	p.L124L	AP000695.6_ENST00000429588.1_RNA|AP000695.4_ENST00000428667.1_RNA|CLDN14_ENST00000399136.1_Silent_p.L124L|CLDN14_ENST00000342108.2_Silent_p.L124L|CLDN14_ENST00000399135.1_Silent_p.L124L|CLDN14_ENST00000399139.1_Silent_p.L124L	NM_144492.2	NP_652763.1	O95500	CLD14_HUMAN	claudin 14	124					calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|lung(5)|skin(1)	7						CCAGGATGAAGAGGGTGCCGC	0.657000													46	78					0	0	0.003610	0	0
GPANK1	7918	broad.mit.edu	37	6	31632160	31632160	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:31632160C>A	ENST00000375906.1	-	3	780	c.96G>T	c.(94-96)gaG>gaT	p.E32D	GPANK1_ENST00000375893.2_Missense_Mutation_p.E32D|GPANK1_ENST00000375896.4_Missense_Mutation_p.E32D|GPANK1_ENST00000375895.2_Missense_Mutation_p.E32D|GPANK1_ENST00000375900.4_Missense_Mutation_p.E32D	NM_001199237.1	NP_001186166.1	O95872	GPAN1_HUMAN	G patch domain and ankyrin repeats 1	32						intracellular	nucleic acid binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(7)	12						CCAGGGTGGACTCTGGCTTCT	0.622000													13	602					3.27435e-08	7.7826e-08	0.002450	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110519966	110519966	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:110519966G>A	ENST00000378402.5	+	69	11173	c.11069G>A	c.(11068-11070)gGc>gAc	p.G3690D		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3690					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GACATAGATGGCTCCTTTCTG	0.423000										HNSCC(38;0.096)			56	36					0	0	0.003610	0	0
EFCAB13	124989	broad.mit.edu	37	17	45412682	45412682	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:45412682T>A	ENST00000331493.2	+	5	562	c.151T>A	c.(151-153)Tca>Aca	p.S51T	EFCAB13_ENST00000517484.1_Missense_Mutation_p.S51T|ITGB3_ENST00000435993.2_3'UTR|EFCAB13_ENST00000520802.1_Intron|ITGB3_ENST00000560629.1_3'UTR	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		GAAGGAAATTTCACCGGAAAT	0.303000													24	61					0	0	0.005443	0	0
GLI2	2736	broad.mit.edu	37	2	121745856	121745856	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:121745856C>T	ENST00000452319.1	+	14	2426	c.2366C>T	c.(2365-2367)tCg>tTg	p.S789L	GLI2_ENST00000361492.4_Missense_Mutation_p.S789L|GLI2_ENST00000314490.11_Missense_Mutation_p.S461L			P10070	GLI2_HUMAN	GLI family zinc finger 2	789	Ser-rich.				axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CCGCGGCTGTCGGAGCTGTCC	0.716000													7	3					0	0	0.004482	0	0
XPO5	57510	broad.mit.edu	37	6	43494441	43494441	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:43494441G>A	ENST00000265351.7	-	27	3175	c.2965C>T	c.(2965-2967)Ccc>Tcc	p.P989S	POLR1C_ENST00000304004.3_Intron	NM_020750.2	NP_065801.1	Q9HAV4	XPO5_HUMAN	exportin 5	989					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(4)|lung(10)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	34	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			TCTGCTGGGGGAGCACTACTG	0.493000													10	34					0	0	0.000978	0	0
KRT71	112802	broad.mit.edu	37	12	52939362	52939362	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:52939362G>A	ENST00000267119.5	-	8	1416	c.1347C>T	c.(1345-1347)tcC>tcT	p.S449S		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	449	Tail.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		TGCTGACAGGGGAGGGAAATT	0.428000													25	50					0	0	0.005443	0	0
NPY2R	4887	broad.mit.edu	37	4	156135355	156135355	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:156135355C>T	ENST00000329476.3	+	2	753	c.264C>T	c.(262-264)ttC>ttT	p.F88F	NPY2R_ENST00000506608.1_Silent_p.F88F	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	88					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				CCAACTTTTTCATTGCCAATC	0.473000													24	43					0	0	0.002780	0	0
PLCB1	23236	broad.mit.edu	37	20	8689378	8689378	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:8689378C>T	ENST00000378641.3	+	12	1704	c.1229C>T	c.(1228-1230)tCg>tTg	p.S410L	PLCB1_ENST00000378637.2_Missense_Mutation_p.S410L|PLCB1_ENST00000338037.6_Missense_Mutation_p.S410L	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	410	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						ATTCTCCTTTCGTTTGAGAAC	0.358000													12	34					0	0	0.002450	0	0
DSP	1832	broad.mit.edu	37	6	7580622	7580622	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:7580622G>A	ENST00000379802.3	+	23	4540	c.4199G>A	c.(4198-4200)cGa>cAa	p.R1400Q	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1400	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AATCTCACCCGAGAAAACAGG	0.493000													26	71					0	0	0.003954	0	0
SIL1	64374	broad.mit.edu	37	5	138356955	138356955	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:138356955G>A	ENST00000394817.2	-	7	811	c.672C>T	c.(670-672)tcC>tcT	p.S224S	CTB-46B19.2_ENST00000512875.2_RNA|CTB-46B19.2_ENST00000510110.1_RNA|SIL1_ENST00000265195.5_Silent_p.S224S|SIL1_ENST00000509534.1_Silent_p.S231S	NM_022464.4	NP_071909.1	Q9H173	SIL1_HUMAN	SIL1 nucleotide exchange factor	224	Interaction with HSPA5 and localization to the endoplasmic reticulum (By similarity).				intracellular protein transport|protein folding|transmembrane transport	endoplasmic reticulum lumen	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GACCACCAAAGGAAAGCAGGT	0.527000									Marinesco-Sjgren syndrome				23	16					0	0	0.003954	0	0
ZCCHC4	29063	broad.mit.edu	37	4	25366778	25366778	+	Silent	SNP	A	A	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:25366778A>C	ENST00000302874.4	+	12	1420	c.1396A>C	c.(1396-1398)Aga>Cga	p.R466R		NM_024936.2	NP_079212.2	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	466							methyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)	9		Breast(46;0.0503)				TACATCTAAGAGAGCTAACAA	0.388000													20	63					0	0	0.002299	0	0
SMARCC2	6601	broad.mit.edu	37	12	56565503	56565503	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:56565503G>A	ENST00000394023.3	-	21	2250	c.2145C>T	c.(2143-2145)gtC>gtT	p.V715V	SMARCC2_ENST00000267064.4_Silent_p.V684V|SMARCC2_ENST00000550164.1_Silent_p.V715V|SMARCC2_ENST00000347471.4_Silent_p.V715V|RP11-977G19.5_ENST00000553176.1_RNA	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	684					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			CTCGGGGATCGACGACAGAGG	0.582000													51	84					0	0	0.003610	0	0
SMC6	79677	broad.mit.edu	37	2	17906555	17906555	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:17906555C>T	ENST00000448223.2	-	9	964	c.695G>A	c.(694-696)aGa>aAa	p.R232K	SMC6_ENST00000351948.4_Missense_Mutation_p.R232K|SMC6_ENST00000381272.4_Missense_Mutation_p.R258K|SMC6_ENST00000402989.1_Missense_Mutation_p.R232K	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	232					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTCCTTTGTTCTTTCTTTCGT	0.303000													4	30					0	0	0.001168	0	0
GRB7	2886	broad.mit.edu	37	17	37899515	37899515	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:37899515G>A	ENST00000309156.4	+	5	803	c.546G>A	c.(544-546)cgG>cgA	p.R182R	GRB7_ENST00000394204.1_Silent_p.R182R|GRB7_ENST00000394209.2_Silent_p.R182R|GRB7_ENST00000309185.3_Silent_p.R182R|GRB7_ENST00000445327.2_Silent_p.R205R|GRB7_ENST00000394211.3_Silent_p.R182R|GRB7_ENST00000578702.1_3'UTR	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	182	Ras-associating.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TCGTCTTCCGGAAAAACTTCG	0.607000													19	61					0	0	0.000958	0	0
SEC31B	25956	broad.mit.edu	37	10	102249077	102249077	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:102249077G>A	ENST00000370345.3	-	23	3200	c.3103C>T	c.(3103-3105)Ccc>Tcc	p.P1035S		NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	1035	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		GGCTGTGAGGGAAGAATCCCT	0.542000													42	47					0	0	0.002522	0	0
CGNL1	84952	broad.mit.edu	37	15	57810601	57810601	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:57810601G>A	ENST00000281282.5	+	10	2699	c.2621G>A	c.(2620-2622)cGa>cAa	p.R874Q		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	874						myosin complex|tight junction	motor activity	p.R874Q(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		GGAGAAATACGACAGTTAGAG	0.478000													7	9					0	0	0.004482	0	0
PCK1	5105	broad.mit.edu	37	20	56138731	56138731	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:56138731G>A	ENST00000319441.4	+	6	1073	c.909G>A	c.(907-909)tgG>tgA	p.W303*	PCK1_ENST00000543666.1_Intron|PCK1_ENST00000535860.1_Nonsense_Mutation_p.W171*	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	303					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			TCCCCGGGTGGAAGGTTGAGT	0.557000													47	74					0	0	0.003610	0	0
EFCAB14	9813	broad.mit.edu	37	1	47181973	47181973	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:47181973G>A	ENST00000371933.3	-	2	1304	c.328C>T	c.(328-330)Cga>Tga	p.R110*	EFCAB14_ENST00000544071.1_Nonsense_Mutation_p.R110*	NM_014774.2	NP_055589.1			EF-hand calcium binding domain 14																		TTACTTGTTCGAAATTTTTCC	0.443000													9	25					0	0	0.004482	0	0
DPY19L3	147991	broad.mit.edu	37	19	32971434	32971434	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:32971434C>T	ENST00000342179.5	+	18	2175	c.1960C>T	c.(1960-1962)Cgg>Tgg	p.R654W	DPY19L3_ENST00000586987.1_Missense_Mutation_p.R654W|DPY19L3_ENST00000392250.2_Missense_Mutation_p.R654W	NM_207325.2	NP_997208.2	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	654						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					CTGCCGACTCCGGGACCTGCT	0.607000													30	44					0	0	0.002096	0	0
BCMO1	53630	broad.mit.edu	37	16	81303860	81303860	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:81303860G>A	ENST00000258168.2	+	7	1401	c.940G>A	c.(940-942)Gaa>Aaa	p.E314K	BCMO1_ENST00000425577.2_Missense_Mutation_p.E245K	NM_017429.2	NP_059125.2	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase 1	314					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(9)|prostate(3)|skin(3)|stomach(1)	23						CAACGCCTACGAAGAGGACGG	0.522000													53	29					0	0	0.003610	0	0
ATP8A1	10396	broad.mit.edu	37	4	42414957	42414957	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:42414957C>T	ENST00000381668.5	-	37	3702	c.3471G>A	c.(3469-3471)acG>acA	p.T1157T	ATP8A1_ENST00000264449.10_Silent_p.T1142T	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	1157					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity	p.T1157T(1)		NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	GCCTCTGTTTCGTGGTATCAT	0.458000													10	18					0	0	0.000978	0	0
EPOR	2057	broad.mit.edu	37	19	11489125	11489125	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:11489125G>A	ENST00000222139.6	-	8	1166	c.1062C>T	c.(1060-1062)ccC>ccT	p.P354P	EPOR_ENST00000592375.2_3'UTR	NM_000121.3	NP_000112.1	P19235	EPOR_HUMAN	erythropoietin receptor	354						extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	GCTCCAGCAGGGGGCCCTCAT	0.657000											OREG0025254	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	48					0	0	0.002096	0	0
KDM5B	10765	broad.mit.edu	37	1	202731858	202731858	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:202731858G>A	ENST00000367265.3	-	7	2051	c.887C>T	c.(886-888)cCc>cTc	p.P296L	KDM5B_ENST00000367264.2_Missense_Mutation_p.P332L	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	296					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						TCGACTCTTGGGCTTTTCCTT	0.388000													42	211					0	0	0.003610	0	0
DMTF1	9988	broad.mit.edu	37	7	86817419	86817419	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:86817419G>A	ENST00000414194.2	+	13	2207	c.415G>A	c.(415-417)Ggt>Agt	p.G139S	DMTF1_ENST00000432937.2_Missense_Mutation_p.G317S|DMTF1_ENST00000331242.7_Missense_Mutation_p.G405S|DMTF1_ENST00000413276.2_Intron|DMTF1_ENST00000394703.5_Missense_Mutation_p.G405S			Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	405	Interaction with CCND2 (By similarity).|Required for DNA-binding (By similarity).|Required for transcriptional activation (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)	16	Esophageal squamous(14;0.0058)					CTTAATAAAAGGTCTTAAACA	0.433000													17	25					0	0	0.004990	0	0
RPL11	6135	broad.mit.edu	37	1	24020315	24020315	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:24020315C>T	ENST00000374550.3	+	3	221	c.176C>T	c.(175-177)tCc>tTc	p.S59F	RPL11_ENST00000482370.1_3'UTR	NM_000975.3|NM_001199802.1	NP_000966.2|NP_001186731.1	P62913	RL11_HUMAN	ribosomal protein L11	59					endocrine pancreas development|protein localization to nucleus|protein targeting|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)	6		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.13e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		ACTGTCAGATCCTTTGGCATC	0.493000													17	43					0	0	0.001216	0	0
MAB21L3	126868	broad.mit.edu	37	1	116666948	116666948	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:116666948G>A	ENST00000369500.3	+	4	716	c.451G>A	c.(451-453)Gaa>Aaa	p.E151K	MAB21L3_ENST00000464946.1_3'UTR	NM_152367.2	NP_689580.2	Q8N8X9	MB213_HUMAN	mab-21-like 3 (C. elegans)	151										breast(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|urinary_tract(1)	19						GAAGCTGGTGGAAAATGCAGT	0.488000													48	48					0	0	0.003610	0	0
LRIT3	345193	broad.mit.edu	37	4	110791065	110791065	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:110791065G>A	ENST00000327908.3	+	4	1375	c.611G>A	c.(610-612)tGg>tAg	p.W204*	LRIT3_ENST00000379920.3_Nonsense_Mutation_p.W342*|LRIT3_ENST00000409621.2_Nonsense_Mutation_p.W204*|LRIT3_ENST00000594814.1_Nonsense_Mutation_p.W387*			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	342	LRRCT.					integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		TCATATCTTTGGtcctcttcc	0.473000													71	84					0	0	0.003610	0	0
SALL3	27164	broad.mit.edu	37	18	76754898	76754898	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr18:76754898G>A	ENST00000536229.3	+	1	3217	c.2508G>A	c.(2506-2508)agG>agA	p.R836R	SALL3_ENST00000537592.2_Silent_p.R969R|SALL3_ENST00000575389.2_Silent_p.R969R			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1041					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TCCTGAGCAGGGAGCGGGGTA	0.662000													13	14					0	0	0.001368	0	0
NOL3	8996	broad.mit.edu	37	16	67208605	67208605	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:67208605G>A	ENST00000432069.2	+	5	949	c.377G>A	c.(376-378)gGg>gAg	p.G126E	NOL3_ENST00000268605.7_Missense_Mutation_p.G126E|NOL3_ENST00000568146.1_Missense_Mutation_p.G123S|NOL3_ENST00000564053.1_Missense_Mutation_p.G188E	NM_001276309.1|NM_001276312.1|NM_001276319.1	NP_001263238.1|NP_001263241.1|NP_001263248.1	O60936	NOL3_HUMAN	nucleolar protein 3 (apoptosis repressor with CARD domain)	126					anti-apoptosis|apoptosis|mRNA processing|RNA splicing	cytosol|nucleolus	identical protein binding|RNA binding			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		ACATGCCCCGGGTTGCCCAGA	0.711000													12	18					0	0	0.001368	0	0
LUC7L	55692	broad.mit.edu	37	16	239275	239275	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:239275G>A	ENST00000293872.8	-	10	1148	c.1038C>T	c.(1036-1038)ccC>ccT	p.P346P	LUC7L_ENST00000337351.4_3'UTR|LUC7L_ENST00000397783.1_3'UTR	NM_201412.1	NP_958815.1	Q9NQ29	LUC7L_HUMAN	LUC7-like (S. cerevisiae)	346	Arg/Ser-rich.						metal ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	11		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				TCCAGTCCGGGGGCCCTCGCT	0.637000													25	105					0	0	0.003954	0	0
SLC44A4	80736	broad.mit.edu	37	6	31839334	31839334	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:31839334C>T	ENST00000544672.1	-	8	602	c.306G>A	c.(304-306)ctG>ctA	p.L102L	SLC44A4_ENST00000375562.4_Silent_p.L136L|SLC44A4_ENST00000229729.6_Silent_p.L178L	NM_001178045.1	NP_001171516.1	Q53GD3	CTL4_HUMAN	solute carrier family 44, member 4	178						integral to membrane|plasma membrane	choline transmembrane transporter activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(1)|urinary_tract(2)	35					Choline(DB00122)	AGCAGCGCCCCAGAGCTGGAA	0.657000													89	167					0	0	0.003610	0	0
ZBTB12	221527	broad.mit.edu	37	6	31868370	31868370	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:31868370G>A	ENST00000375527.2	-	2	888	c.713C>T	c.(712-714)tCc>tTc	p.S238F	C2_ENST00000469372.1_Intron	NM_181842.2	NP_862825.1	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	238	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)|prostate(1)|skin(1)	10						GCCACCCACGGAGCCTCCAAT	0.662000													126	332					0	0	0.003610	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51919961	51919961	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:51919961T>C	ENST00000353836.5	-	3	886	c.665A>G	c.(664-666)aAg>aGg	p.K222R	SIGLEC10_ENST00000439889.2_Missense_Mutation_p.K164R|SIGLEC10_ENST00000441969.3_Missense_Mutation_p.K164R|CTD-2616J11.2_ENST00000532688.1_RNA|SIGLEC10_ENST00000432469.2_Intron|SIGLEC10_ENST00000356298.5_Missense_Mutation_p.K222R|SIGLEC10_ENST00000525998.1_Missense_Mutation_p.K222R|SIGLEC10_ENST00000339313.5_Missense_Mutation_p.K222R|SIGLEC10_ENST00000442846.3_Missense_Mutation_p.K164R|SIGLEC10_ENST00000436984.2_Missense_Mutation_p.K174R	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	222	Ig-like C2-type 1.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GCTCACACCCTTTCTGGAGAA	0.637000													31	47					0	0	0.002445	0	0
CAP2	10486	broad.mit.edu	37	6	17463268	17463268	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:17463268C>T	ENST00000229922.2	+	4	796	c.264C>T	c.(262-264)ttC>ttT	p.F88F	CAP2_ENST00000378990.2_Intron|CAP2_ENST00000465994.1_Silent_p.F88F|CAP2_ENST00000489374.1_Silent_p.F88F|CAP2_ENST00000493172.1_Intron	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	88					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			AGCGGGCTTTCCTTCTGATGG	0.498000													26	77					0	0	0.001512	0	0
KRT36	8689	broad.mit.edu	37	17	39646004	39646004	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:39646004C>T	ENST00000328119.6	-	1	112	c.113G>A	c.(112-114)aGg>aAg	p.R38K	KRT36_ENST00000393986.2_Intron	NM_003771.4	NP_003762.1	O76013	KRT36_HUMAN	keratin 36	38	Head.					intermediate filament	protein binding|structural constituent of epidermis			breast(2)|cervix(1)|kidney(2)|large_intestine(3)|lung(8)|skin(1)	17		Breast(137;0.000286)				ACTGGGGACCCTGCAGGAGCC	0.627000													20	46					0	0	0.002299	0	0
HOMER2	9455	broad.mit.edu	37	15	83527872	83527872	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:83527872C>T	ENST00000304231.8	-	5	628	c.436G>A	c.(436-438)Ggg>Agg	p.G146R	HOMER2_ENST00000399166.2_Missense_Mutation_p.G135R|HOMER2_ENST00000426485.1_Missense_Mutation_p.G146R|HOMER2_ENST00000450735.2_Missense_Mutation_p.G135R	NM_199330.2	NP_955362.1	Q9NSB8	HOME2_HUMAN	homer homolog 2 (Drosophila)	146					metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				cervix(1)|endometrium(2)|lung(6)	9						TCGTCCGTCCCGTTGACACTG	0.522000													153	53					0	0	0.003610	0	0
AP1B1	162	broad.mit.edu	37	22	29727844	29727844	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:29727844C>T	ENST00000357586.2	-	18	2557	c.2371G>A	c.(2371-2373)Gtg>Atg	p.V791M	AP1B1_ENST00000317368.7_Missense_Mutation_p.V764M|AP1B1_ENST00000472057.1_5'UTR|AP1B1_ENST00000402502.1_Missense_Mutation_p.V784M|AP1B1_ENST00000405198.1_Missense_Mutation_p.V791M|AP1B1_ENST00000432560.2_Missense_Mutation_p.V784M|AP1B1_ENST00000356015.2_Missense_Mutation_p.V784M|AP1B1_ENST00000415447.1_Missense_Mutation_p.V784M	NM_001127.3	NP_001118.3	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	791					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GAGATCTCCACTGTCTGGTTG	0.672000													24	64					0	0	0.002780	0	0
CPNE3	8895	broad.mit.edu	37	8	87567208	87567208	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:87567208C>T	ENST00000521271.1	+	15	1412	c.1250C>T	c.(1249-1251)gCt>gTt	p.A417V	CPNE3_ENST00000198765.4_Missense_Mutation_p.A417V	NM_003909.3	NP_003900.1	O75131	CPNE3_HUMAN	copine III	417	VWFA.				lipid metabolic process|vesicle-mediated transport	cytosol	calcium-dependent phospholipid binding|protein serine/threonine kinase activity|transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	23						CAGCAGACAGCTTCTGTAAGT	0.438000													28	91					0	0	0.001512	0	0
TMEM52	339456	broad.mit.edu	37	1	1849693	1849693	+	Splice_Site	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:1849693G>A	ENST00000378602.3	-	1	543	c.304_splice	c.e1+1	p.T101_splice	TMEM52_ENST00000310991.3_Splice_Site_p.T116_splice			Q8NDY8	TMM52_HUMAN	transmembrane protein 52	116						integral to membrane				NS(1)|prostate(1)|stomach(1)	3	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGCACTCACAGGTCACAGTGC	0.637000													23	57					0	0	0.002780	0	0
MUC16	94025	broad.mit.edu	37	19	9059329	9059329	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:9059329G>A	ENST00000397910.4	-	3	28320	c.28117C>T	c.(28117-28119)Cct>Tct	p.P9373S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9375	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCCCCAGAAGGACCTGTTTTG	0.507000													65	112					0	0	0.003610	0	0
ZNF586	54807	broad.mit.edu	37	19	58288009	58288009	+	Silent	SNP	G	G	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:58288009G>T	ENST00000391702.3	+	3	373	c.6G>T	c.(4-6)ctG>ctT	p.L2L	ZNF586_ENST00000599802.1_Intron|ZNF586_ENST00000598885.1_Intron|ZNF586_ENST00000396154.2_Silent_p.L45L|ZNF586_ENST00000396150.4_Intron|ZNF586_ENST00000598183.1_Intron	NM_001204814.1	NP_001191743.1	Q9NXT0	ZN586_HUMAN	zinc finger protein 586	45					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)	15		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACGTGATGCTGGAGACCTTGA	0.473000													6	296					0.00307968	0.00723725	0.003080	1	0
HDLBP	3069	broad.mit.edu	37	2	242189270	242189270	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:242189270G>A	ENST00000391975.1	-	12	1725	c.1498C>T	c.(1498-1500)Ctt>Ttt	p.L500F	HDLBP_ENST00000391976.2_Missense_Mutation_p.L500F|HDLBP_ENST00000310931.4_Missense_Mutation_p.L500F|HDLBP_ENST00000476807.1_5'UTR|HDLBP_ENST00000427183.2_Missense_Mutation_p.L467F	NM_203346.3	NP_976221.1	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	500	KH 5.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		CGAGATGCAAGCTCCAGCAGC	0.612000													11	40					0	0	0.000673	0	0
KIAA1109	84162	broad.mit.edu	37	4	123201052	123201052	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:123201052C>T	ENST00000264501.4	+	51	9087	c.8714C>T	c.(8713-8715)cCt>cTt	p.P2905L	KIAA1109_ENST00000388738.3_Missense_Mutation_p.P2905L|KIAA1109_ENST00000455637.1_Missense_Mutation_p.P2905L			Q2LD37	K1109_HUMAN	KIAA1109	2905					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						CCTCAGCACCCTGCCACCTTA	0.443000													19	78					0	0	0.006122	0	0
SRPR	6734	broad.mit.edu	37	11	126136502	126136502	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:126136502G>A	ENST00000332118.6	-	6	863	c.709C>T	c.(709-711)Cca>Tca	p.P237S	SRPR_ENST00000532259.1_Missense_Mutation_p.P209S	NM_003139.3	NP_003130.2	P08240	SRPR_HUMAN	signal recognition particle receptor (docking protein)	237					SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding			endometrium(7)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)	21	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)		TTCTCCTTTGGAGCATCTGAC	0.498000													68	37					0	0	0.003610	0	0
VPS13D	55187	broad.mit.edu	37	1	12337829	12337829	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:12337829C>T	ENST00000358136.3	+	19	4314	c.4184C>T	c.(4183-4185)cCt>cTt	p.P1395L	VPS13D_ENST00000356315.4_Missense_Mutation_p.P1395L	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1395					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCGGGGAGTCCTGAGTTGTTG	0.468000													40	50					0	0	0.001706	0	0
AOX1	316	broad.mit.edu	37	2	201460032	201460032	+	Silent	SNP	A	A	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:201460032A>T	ENST00000374700.2	+	3	382	c.141A>T	c.(139-141)ggA>ggT	p.G47G		NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	47	2Fe-2S ferredoxin-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GTGGAGGAGGAGGCTGTGGTG	0.423000													7	33					0	0	0.003080	0	0
RPRD2	23248	broad.mit.edu	37	1	150429863	150429863	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:150429863C>T	ENST00000401000.4	+	7	957	c.892C>T	c.(892-894)Cca>Tca	p.P298S	RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Missense_Mutation_p.P324S|RPRD2_ENST00000539519.1_Missense_Mutation_p.P298S			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	324							protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						AGTTCCTTCCCCAAGCATGGA	0.473000													115	124					0	0	0.003610	0	0
NPHP4	261734	broad.mit.edu	37	1	6007208	6007208	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:6007208G>A	ENST00000378156.4	-	9	1340	c.1075C>T	c.(1075-1077)Cag>Tag	p.Q359*	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	359					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		TACTCCAGCTGGAAGATGACC	0.572000													22	60					0	0	0.001523	0	0
FCHO2	115548	broad.mit.edu	37	5	72337118	72337118	+	Splice_Site	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:72337118G>A	ENST00000430046.2	+	11	1031	c.914_splice	c.e11-1	p.V305_splice	FCHO2_ENST00000512348.1_Splice_Site_p.V272_splice|FCHO2_ENST00000341845.6_Splice_Site_p.V305_splice	NM_001146032.1|NM_138782.2	NP_001139504.1|NP_620137.2	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2	305										cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	17		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		GTTTTAATAGGGAATGTCCTG	0.249000													7	5					0	0	0.000443	0	0
ZAN	7455	broad.mit.edu	37	7	100390094	100390094	+	RNA	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:100390094C>T	ENST00000542585.1	+	0	7925				ZAN_ENST00000443370.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TTGCCAGGTCCTCAGTGGGTA	0.677000													41	43					0	0	0.001706	0	0
ATP6V1C2	245973	broad.mit.edu	37	2	10918750	10918750	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:10918750G>A	ENST00000381661.3	+	11	987	c.878G>A	c.(877-879)tGg>tAg	p.W293*	ATP6V1C2_ENST00000272238.4_Nonsense_Mutation_p.W339*	NM_144583.3	NP_653184.2	Q8NEY4	VATC2_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2	339					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		TTCATTGCCTGGATCCACATC	0.617000													44	47					0	0	0.003610	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303507	151303507	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chrX:151303507G>A	ENST00000370323.4	-	4	902	c.586C>T	c.(586-588)Ccc>Tcc	p.P196S	MAGEA10_ENST00000244096.3_Missense_Mutation_p.P196S|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	196	MAGE.									endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					TGGCCAGTGGGATCCACTTCC	0.493000													38	12					0	0	0.005524	0	0
ATG2A	23130	broad.mit.edu	37	11	64677517	64677517	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:64677517G>A	ENST00000421419.2	-	13	1972	c.1858C>T	c.(1858-1860)Ctg>Ttg	p.L620L	ATG2A_ENST00000377264.3_Silent_p.L620L			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	620							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						CTCACCAGCAGGCCGGCTGGA	0.731000													15	6					0	0	0.004007	0	0
DNMBP	23268	broad.mit.edu	37	10	101643929	101643929	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:101643929G>A	ENST00000342239.3	-	15	3999	c.3908C>T	c.(3907-3909)tCc>tTc	p.S1303F	DNMBP_ENST00000324109.4_Missense_Mutation_p.S1279F|DNMBP_ENST00000543621.1_Missense_Mutation_p.S525F|DNMBP_ENST00000540316.1_Missense_Mutation_p.S215F			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1279	SH3 5.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		GGCCAGGAGGGAGGCCCGGAG	0.498000													50	87					0	0	0.003610	0	0
CLEC4F	165530	broad.mit.edu	37	2	71043176	71043176	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:71043176T>C	ENST00000272367.2	-	4	1413	c.1337A>G	c.(1336-1338)aAg>aGg	p.K446R	CLEC4F_ENST00000426626.1_Missense_Mutation_p.K446R	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	446					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						ATGGAGGGTCTTCAGGCGACT	0.522000													38	47					0	0	0.002522	0	0
LHX8	431707	broad.mit.edu	37	1	75608881	75608881	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:75608881C>T	ENST00000294638.5	+	6	1132	c.468C>T	c.(466-468)gtC>gtT	p.V156V	LHX8_ENST00000356261.3_Silent_p.V146V	NM_001001933.1	NP_001001933.1	Q68G74	LHX8_HUMAN	LIM homeobox 8	156	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(18)|ovary(3)|urinary_tract(1)	30						AGGGGAATGTCTATCACTTGG	0.483000													18	39					0	0	0.001216	0	0
LGI4	163175	broad.mit.edu	37	19	35616179	35616179	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:35616179G>A	ENST00000310123.3	-	9	2051	c.1532C>T	c.(1531-1533)gCc>gTc	p.A511V	LGI4_ENST00000493050.1_5'UTR|LGI4_ENST00000392225.3_3'UTR	NM_139284.2	NP_644813.1	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	511						extracellular region				endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			GCGTCTGCCGGCCATAGTGAT	0.632000													32	61					0	0	0.004289	0	0
FCGBP	8857	broad.mit.edu	37	19	40408578	40408578	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:40408578C>T	ENST00000221347.6	-	8	4268	c.4261G>A	c.(4261-4263)Gag>Aag	p.E1421K		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1421	VWFD 3.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGCACCACCTCCTCCCAGGAG	0.637000													28	68					0	0	0.003755	0	0
SLC38A1	81539	broad.mit.edu	37	12	46591601	46591601	+	Splice_Site	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:46591601C>T	ENST00000398637.5	-	16	1959		c.e16-1		SLC38A1_ENST00000439706.1_Splice_Site|SLC38A1_ENST00000546893.1_Splice_Site|SLC38A1_ENST00000549049.1_Splice_Site|SLC38A1_ENST00000552197.1_Splice_Site	NM_001077484.1|NM_001278387.1|NM_001278388.1|NM_001278389.1|NM_030674.3	NP_001070952.1|NP_001265316.1|NP_001265317.1|NP_001265318.1|NP_109599.3	Q9H2H9	S38A1_HUMAN	solute carrier family 38, member 1						cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			NS(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(2)	23	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			GATGTAACTCCTGTAAAATAA	0.348000													15	36					0	0	0.002450	0	0
FYN	2534	broad.mit.edu	37	6	112035566	112035566	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:112035566G>T	ENST00000354650.3	-	5	934	c.328C>A	c.(328-330)Caa>Aaa	p.Q110K	FYN_ENST00000368682.3_Missense_Mutation_p.Q110K|FYN_ENST00000229470.5_Intron|FYN_ENST00000368678.4_Missense_Mutation_p.Q110K|FYN_ENST00000538466.1_Missense_Mutation_p.Q110K|FYN_ENST00000229471.4_Missense_Mutation_p.Q110K|FYN_ENST00000368667.2_Missense_Mutation_p.Q110K|FYN_ENST00000356013.2_Missense_Mutation_p.Q110K	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	110	SH3.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TTCAATATTTGAAATTTTTCT	0.438000													19	12					1.15919e-05	2.74623e-05	0.001216	1	0
TMEM184C	55751	broad.mit.edu	37	4	148545004	148545004	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:148545004C>T	ENST00000296582.3	+	2	717	c.143C>T	c.(142-144)gCt>gTt	p.A48V	TMEM184C_ENST00000508208.1_Missense_Mutation_p.A48V	NM_018241.2	NP_060711.2	Q9NVA4	T184C_HUMAN	transmembrane protein 184C	48						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(2)|prostate(1)	16						CACACCAAGGCTTGGTTTATT	0.358000													13	55					0	0	0.002450	0	0
SEL1L2	80343	broad.mit.edu	37	20	13936761	13936761	+	Silent	SNP	T	T	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:13936761T>C	ENST00000284951.5	-	2	149	c.75A>G	c.(73-75)gaA>gaG	p.E25E	SEL1L2_ENST00000378072.5_Silent_p.E25E|SEL1L2_ENST00000486903.1_5'UTR			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	25						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						TTTTATTATGTTCCTCTGCTT	0.234000													22	26					0	0	0.002780	0	0
MASP1	5648	broad.mit.edu	37	3	186954183	186954183	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:186954183G>A	ENST00000296280.6	-	11	1701	c.1476C>T	c.(1474-1476)atC>atT	p.I492I	MASP1_ENST00000495249.1_Intron|MASP1_ENST00000392472.2_Silent_p.I379I|MASP1_ENST00000337774.5_Intron	NM_139125.3	NP_624302.1	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	485	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CTGCTGTGAGGATCCAGGACG	0.592000													24	50					0	0	0.002299	0	0
FCGBP	8857	broad.mit.edu	37	19	40408566	40408566	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:40408566C>T	ENST00000221347.6	-	8	4280	c.4273G>A	c.(4273-4275)Gac>Aac	p.D1425N		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1425	VWFD 3.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CAGGGAGAGTCGGGCACCACC	0.622000													23	58					0	0	0.001512	0	0
TF	7018	broad.mit.edu	37	3	133476668	133476668	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:133476668G>A	ENST00000402696.3	+	8	1411	c.926G>A	c.(925-927)gGg>gAg	p.G309E	TF_ENST00000264998.3_Missense_Mutation_p.G182E	NM_001063.3	NP_001054.1	P02787	TRFE_HUMAN	transferrin	309	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	TCTCCTCATGGGAAGGACCTG	0.448000													29	68					0	0	0.002096	0	0
CSMD2	114784	broad.mit.edu	37	1	34037262	34037262	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:34037262C>T	ENST00000373381.4	-	51	8003	c.7827G>A	c.(7825-7827)gaG>gaA	p.E2609E		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2611	Sushi 16.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GATACTGTGTCTCAAAGATAA	0.502000													26	70					0	0	0.001512	0	0
ABHD17A	81926	broad.mit.edu	37	19	1881347	1881347	+	Silent	SNP	A	A	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:1881347A>G	ENST00000292577.7	-	2	652	c.219T>C	c.(217-219)cgT>cgC	p.R73R	ABHD17A_ENST00000590661.1_Silent_p.R73R|ABHD17A_ENST00000250974.9_Silent_p.R73R	NM_001130111.1	NP_001123583.1			abhydrolase domain containing 17A																		GGAAGTCGGCACGCTCCGTCA	0.716000													4	60					0	0	0.001168	0	0
SALL3	27164	broad.mit.edu	37	18	76752273	76752273	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr18:76752273C>T	ENST00000575389.2	+	2	282	c.282C>T	c.(280-282)ttC>ttT	p.F94F	SALL3_ENST00000536229.3_5'UTR|SALL3_ENST00000537592.2_Silent_p.F94F			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CCGAGGACTTCCCCGAGCCTT	0.761000													11	15					0	0	0.002450	0	0
GDF2	2658	broad.mit.edu	37	10	48413677	48413677	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:48413677T>A	ENST00000249598.1	-	2	1350	c.1191A>T	c.(1189-1191)aaA>aaT	p.K397N		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	397					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						TGGGGCTCAGTTTGGTGGGCA	0.587000													19	14					0	0	0.006122	0	0
CPED1	79974	broad.mit.edu	37	7	120906769	120906769	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:120906769C>T	ENST00000310396.5	+	20	3007	c.2540C>T	c.(2539-2541)cCc>cTc	p.P847L		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		AGATCACGTCCCCTAGAGAAT	0.398000													13	52					0	0	0.001855	0	0
CSF2RB	1439	broad.mit.edu	37	22	37325823	37325823	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:37325823C>T	ENST00000262825.5	+	6	909	c.692C>T	c.(691-693)cCa>cTa	p.P231L	CSF2RB_ENST00000536485.1_Missense_Mutation_p.P172L|CSF2RB_ENST00000403662.3_Missense_Mutation_p.P231L|CSF2RB_ENST00000406230.1_Missense_Mutation_p.P231L	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	231	Fibronectin type-III 1.				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	AAGTGGAGCCCAGAGGTTTGC	0.662000													11	32					0	0	0.001368	0	0
KIAA1199	57214	broad.mit.edu	37	15	81173276	81173276	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:81173276G>A	ENST00000394685.3	+	6	835	c.416G>A	c.(415-417)gGt>gAt	p.G139D	KIAA1199_ENST00000220244.3_Missense_Mutation_p.G139D|KIAA1199_ENST00000356249.5_Missense_Mutation_p.G139D			Q8WUJ3	K1199_HUMAN	KIAA1199	139	G8.									breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						CCTTACTATGGTCTGAAGTAC	0.498000													149	49					0	0	0.003610	0	0
ZNF334	55713	broad.mit.edu	37	20	45131707	45131707	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:45131707C>T	ENST00000457685.2	-	6	1480	c.157G>A	c.(157-159)Gaa>Aaa	p.E53K	ZNF334_ENST00000593880.1_Missense_Mutation_p.E114K|ZNF334_ENST00000347606.4_Missense_Mutation_p.E91K			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	91	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				TCTTGGATTTCCTTGTTCTTC	0.338000													15	29					0	0	0.002450	0	0
TMCO2	127391	broad.mit.edu	37	1	40717248	40717248	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:40717248G>A	ENST00000372766.3	+	2	624	c.531G>A	c.(529-531)ggG>ggA	p.G177G	TMCO2_ENST00000468258.1_3'UTR	NM_001008740.3	NP_001008740.1	Q7Z6W1	TMCO2_HUMAN	transmembrane and coiled-coil domains 2	177						integral to membrane				kidney(1)|large_intestine(3)|lung(1)|ovary(1)	6	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			CCACATCAGGGTTTACTTCCC	0.483000													29	54					0	0	0.001786	0	0
ZEB1	6935	broad.mit.edu	37	10	31784735	31784735	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:31784735C>T	ENST00000446923.2	+	3	630	c.239C>T	c.(238-240)cCt>cTt	p.P80L	ZEB1_ENST00000320985.10_Missense_Mutation_p.P96L|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000542815.3_Missense_Mutation_p.P29L|ZEB1_ENST00000361642.5_Missense_Mutation_p.P97L|ZEB1_ENST00000560721.2_Intron	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	96					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				ATCCTGGGGCCTGAAGCTCAG	0.398000													37	24					0	0	0.003610	0	0
KLHL36	79786	broad.mit.edu	37	16	84691408	84691408	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:84691408C>T	ENST00000564996.1	+	3	1136	c.995C>T	c.(994-996)cCc>cTc	p.P332L	KLHL36_ENST00000258157.5_Missense_Mutation_p.P332L	NM_024731.2	NP_079007.2	Q8N4N3	KLH36_HUMAN	kelch-like family member 36	332										endometrium(3)|large_intestine(1)|lung(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						ACGCCGCTGCCCGCCCGGCGG	0.667000													13	10					0	0	0.001368	0	0
HERPUD2	64224	broad.mit.edu	37	7	35709926	35709926	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:35709926G>A	ENST00000396081.1	-	3	1042	c.238C>T	c.(238-240)Cat>Tat	p.H80Y	HERPUD2_ENST00000311350.3_Missense_Mutation_p.H80Y	NM_022373.4	NP_071768.3	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	80	Ubiquitin-like.				response to unfolded protein	integral to membrane				kidney(3)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)	18						TGAACCATATGATACTCATCT	0.363000													18	20					0	0	0.000958	0	0
OPN4	94233	broad.mit.edu	37	10	88417915	88417915	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:88417915G>A	ENST00000372071.2	+	4	677	c.450G>A	c.(448-450)ggG>ggA	p.G150G	OPN4_ENST00000241891.5_Silent_p.G139G	NM_001030015.2	NP_001025186.1	Q9UHM6	OPN4_HUMAN	opsin 4	139					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(5)|ovary(3)	18						GGCTCTTTGGGGAGACAGGTA	0.557000													46	31					0	0	0.003214	0	0
B4GALNT3	283358	broad.mit.edu	37	12	662524	662524	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:662524C>T	ENST00000266383.5	+	14	1448	c.1435C>T	c.(1435-1437)Ctg>Ttg	p.L479L		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	479						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GCGGAAACTCCTGGCTCAGCC	0.627000													58	102					0	0	0.003610	0	0
SEC31B	25956	broad.mit.edu	37	10	102249076	102249076	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:102249076G>A	ENST00000370345.3	-	23	3201	c.3104C>T	c.(3103-3105)cCc>cTc	p.P1035L		NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	1035	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		GGGCTGTGAGGGAAGAATCCC	0.537000													44	47					0	0	0.003610	0	0
ECM2	1842	broad.mit.edu	37	9	95277481	95277481	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:95277481G>A	ENST00000344604.5	-	4	635	c.486C>T	c.(484-486)tcC>tcT	p.S162S	CENPP_ENST00000375587.3_Intron|ECM2_ENST00000444490.2_Intron	NM_001197295.1|NM_001393.3	NP_001184224.1|NP_001384.1	O94769	ECM2_HUMAN	extracellular matrix protein 2, female organ and adipocyte specific	162					cell-matrix adhesion		integrin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27						GTAGAGAATAGGAGACTAATG	0.328000													8	18					0	0	0.004482	0	0
MYH2	4620	broad.mit.edu	37	17	10428264	10428264	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:10428264C>T	ENST00000245503.5	-	34	5165	c.4781G>A	c.(4780-4782)aGa>aAa	p.R1594K	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000532183.1_Intron|MYH2_ENST00000397183.2_Missense_Mutation_p.R1594K|CTC-297N7.7_ENST00000581304.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1594					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						AATGTGGTTTCTCTTCAGCTG	0.468000													45	96					0	0	0.002852	0	0
TLE2	7089	broad.mit.edu	37	19	3009582	3009582	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:3009582G>A	ENST00000262953.6	-	13	1393	c.1131C>T	c.(1129-1131)tcC>tcT	p.S377S	TLE2_ENST00000447365.2_Intron|TLE2_ENST00000426948.2_Silent_p.S391S|TLE2_ENST00000443826.3_Silent_p.S255S|TLE2_ENST00000590536.1_Silent_p.S378S|TLE2_ENST00000586422.1_Intron|TLE2_ENST00000591529.1_Silent_p.S391S|TLE2_ENST00000455444.2_Silent_p.S255S	NM_003260.4	NP_003251.2	Q04725	TLE2_HUMAN	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	377	Pro/Ser-rich.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGACCTGGGGGGACAGGTGGA	0.682000													20	31					0	0	0.002299	0	0
DNMBP	23268	broad.mit.edu	37	10	101646372	101646372	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:101646372C>T	ENST00000342239.3	-	13	3466	c.3375G>A	c.(3373-3375)cgG>cgA	p.R1125R	DNMBP_ENST00000472036.1_5'UTR|DNMBP_ENST00000324109.4_Silent_p.R1101R|DNMBP_ENST00000543621.1_Silent_p.R347R|DNMBP_ENST00000540316.1_Silent_p.R37R			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1101	BAR.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		AGATGACAAGCCGCTCTGTCC	0.473000													61	76					0	0	0.003610	0	0
FOXK2	3607	broad.mit.edu	37	17	80545020	80545020	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:80545020C>T	ENST00000335255.5	+	8	1832	c.1658C>T	c.(1657-1659)cCg>cTg	p.P553L		NM_004514.3	NP_004505.2	Q01167	FOXK2_HUMAN	forkhead box K2	553					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	17	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			CAGACCACCCCGGTCCAGACG	0.532000													52	52					0	0	0.003610	0	0
FCGBP	8857	broad.mit.edu	37	19	40408565	40408565	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:40408565T>A	ENST00000221347.6	-	8	4281	c.4274A>T	c.(4273-4275)gAc>gTc	p.D1425V		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1425	VWFD 3.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCAGGGAGAGTCGGGCACCAC	0.622000													23	56					0	0	0.001512	0	0
FETUB	26998	broad.mit.edu	37	3	186370148	186370148	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:186370148G>A	ENST00000265029.3	+	7	978	c.877G>A	c.(877-879)Gac>Aac	p.D293N	FETUB_ENST00000382136.3_Missense_Mutation_p.D256N|FETUB_ENST00000382134.3_Missense_Mutation_p.D228N|FETUB_ENST00000539949.1_Missense_Mutation_p.D145N|RP11-134F2.2_ENST00000455926.1_RNA|FETUB_ENST00000450521.1_Missense_Mutation_p.D293N|RP11-134F2.2_ENST00000428501.1_RNA	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	293						extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		CCCCCCAACAGACTCCCCCTC	0.512000													43	109					0	0	0.003610	0	0
TROVE2	6738	broad.mit.edu	37	1	193038629	193038629	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:193038629C>T	ENST00000367446.3	+	2	655	c.445C>T	c.(445-447)Cgg>Tgg	p.R149W	TROVE2_ENST00000460715.2_Intron|TROVE2_ENST00000367443.1_Missense_Mutation_p.R149W|TROVE2_ENST00000367445.3_Missense_Mutation_p.R149W|TROVE2_ENST00000400968.2_Missense_Mutation_p.R149W|TROVE2_ENST00000432079.1_Intron|TROVE2_ENST00000367441.1_Missense_Mutation_p.R149W|TROVE2_ENST00000416058.2_5'UTR|TROVE2_ENST00000367444.3_Missense_Mutation_p.R149W	NM_004600.5	NP_004591.2	P10155	RO60_HUMAN	TROVE domain family, member 2	149	TROVE.				transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding			biliary_tract(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|urinary_tract(1)	21						TCGTGCCCTCCGGAAGGCTAT	0.448000													33	109					0	0	0.004878	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69053171	69053171	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:69053171G>A	ENST00000295381.3	+	11	2202	c.1783G>A	c.(1783-1785)Gaa>Aaa	p.E595K	ARHGAP25_ENST00000479844.1_Missense_Mutation_p.E289K|ARHGAP25_ENST00000409220.1_Missense_Mutation_p.E589K|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.E556K|ARHGAP25_ENST00000409202.3_Missense_Mutation_p.E596K|ARHGAP25_ENST00000409030.3_Missense_Mutation_p.E588K	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	595					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						GCTCAATGAAGAACTGGAGAA	0.468000													41	68					0	0	0.002222	0	0
SVOP	55530	broad.mit.edu	37	12	109306311	109306311	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:109306311C>T	ENST00000299134.5	-	14	1450	c.1451G>A	c.(1450-1452)aGt>aAt	p.484_484insN		NM_018711.2	NP_061181.1	Q8N4V2	SVOP_HUMAN	SV2 related protein homolog (rat)	0						cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity			breast(2)|lung(4)	6						CCATCGGTCACTATTCCTGAG	0.617000													82	59					0	0	0.003610	0	0
PXDNL	137902	broad.mit.edu	37	8	52339266	52339266	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:52339266C>T	ENST00000356297.4	-	13	1678	c.1578G>A	c.(1576-1578)aaG>aaA	p.K526K	PXDNL_ENST00000543296.1_Silent_p.K526K	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	526	Ig-like C2-type 4.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGTTTATATTCTTTCCAACCT	0.338000													12	32					0	0	0.001855	0	0
N4BP1	9683	broad.mit.edu	37	16	48587558	48587558	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:48587558A>G	ENST00000262384.3	-	3	2148	c.1912T>C	c.(1912-1914)Tct>Cct	p.S638P		NM_153029.3	NP_694574.3	O75113	N4BP1_HUMAN	NEDD4 binding protein 1	638					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body				breast(3)|kidney(2)|lung(11)|urinary_tract(1)	17		all_cancers(37;0.179)|all_lung(18;0.11)				CCACGACAAGAAAAGAACTTT	0.343000													9	1					0	0	0.000673	0	0
GABRP	2568	broad.mit.edu	37	5	170224519	170224519	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:170224519G>A	ENST00000518525.1	+	7	972	c.508G>A	c.(508-510)Gac>Aac	p.D170N	GABRP_ENST00000265294.4_Missense_Mutation_p.D170N|GABRP_ENST00000519385.1_Missense_Mutation_p.D170N|GABRP_ENST00000519598.1_Missense_Mutation_p.D170N			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	170						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATACCCCATGGACACACAGAC	0.408000													35	19					0	0	0.005524	0	0
SOX9	6662	broad.mit.edu	37	17	70119866	70119866	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:70119866G>A	ENST00000245479.2	+	3	1240	c.868G>A	c.(868-870)Gat>Aat	p.D290N		NM_000346.3	NP_000337.1	P48436	SOX9_HUMAN	SRY (sex determining region Y)-box 9	290					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(5)|pancreas(1)|upper_aerodigestive_tract(2)	26		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			CGAGACCTTCGATGTCAACGA	0.662000													19	49					0	0	0.001523	0	0
MS4A10	341116	broad.mit.edu	37	11	60565891	60565891	+	Missense_Mutation	SNP	C	C	T	rs141894920		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:60565891C>T	ENST00000308287.1	+	7	722	c.626C>T	c.(625-627)cCg>cTg	p.P209L		NM_206893.3	NP_996776.2	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member 10	209						integral to membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|skin(2)	21						TGCCTTGTTCCGAATACACCA	0.547000													33	22					0	0	0.002445	0	0
HNRNPA1L2	144983	broad.mit.edu	37	13	53216577	53216577	+	Translation_Start_Site	SNP	C	C	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr13:53216577C>A	ENST00000342657.3	+	0	1023				HNRNPA1L2_ENST00000398039.1_De_novo_Start_OutOfFrame|HNRNPA1L2_ENST00000357495.2_De_novo_Start_OutOfFrame	NM_001011724.1	NP_001011724.1	Q32P51	RA1L2_HUMAN	heterogeneous nuclear ribonucleoprotein A1-like 2						mRNA processing|mRNA transport|RNA splicing	cytoplasm|spliceosomal complex	nucleotide binding|RNA binding			cervix(1)|large_intestine(1)|lung(5)	7						TTTTTCTGCCCGTGGACGCCG	0.443000													6	191					0.000274275	0.00064768	0.004482	1	0
SIGLECL1	284369	broad.mit.edu	37	19	51770743	51770743	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:51770743G>A	ENST00000316401.7	+	5	908	c.527G>A	c.(526-528)gGa>gAa	p.G176E	CTD-3187F8.2_ENST00000597569.1_RNA|SIGLECL1_ENST00000597824.1_Missense_Mutation_p.G82E|SIGLECL1_ENST00000593968.1_3'UTR	NM_173635.1	NP_775906.1			SIGLEC family like 1																		GAGGAACCAGGAAAACCCGTA	0.458000													39	83					0	0	0.001706	0	0
PDE6B	5158	broad.mit.edu	37	4	619805	619805	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:619805C>T	ENST00000255622.6	+	1	433	c.390C>T	c.(388-390)atC>atT	p.I130I	PDE6B_ENST00000496514.1_Silent_p.I130I	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	130	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						ACTCCGAGATCGTCTTCCCAC	0.667000													7	15					0	0	0.004482	0	0
DLC1	10395	broad.mit.edu	37	8	12958028	12958028	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:12958028G>A	ENST00000276297.4	-	9	2227	c.1818C>T	c.(1816-1818)caC>caT	p.H606H	DLC1_ENST00000358919.2_Silent_p.H169H|DLC1_ENST00000520226.1_Silent_p.H95H|DLC1_ENST00000512044.2_Silent_p.H203H	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	606					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						TGGGGGGCGCGTGGCTGGGGA	0.677000													72	135					0	0	0.003610	0	0
CDH4	1002	broad.mit.edu	37	20	60498611	60498611	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:60498611G>A	ENST00000360469.5	+	10	1565	c.1477G>A	c.(1477-1479)Ggg>Agg	p.G493R	CDH4_ENST00000543233.1_Missense_Mutation_p.G419R	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	493	Cadherin 3.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GTCCACGGCAGGGGTGACCAT	0.607000													13	27					0	0	0.001855	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906733	13906733	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:13906733G>A	ENST00000279593.3	-	3	737	c.528C>T	c.(526-528)ttC>ttT	p.F176F		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	176					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGTAGCCAGGGAAATAGGTGG	0.478000													51	88					0	0	0.003610	0	0
EPB41L3	23136	broad.mit.edu	37	18	5410589	5410589	+	Silent	SNP	G	G	A	rs140128908		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr18:5410589G>A	ENST00000341928.2	-	14	2437	c.2097C>T	c.(2095-2097)gcC>gcT	p.A699A	EPB41L3_ENST00000542146.1_5'UTR|EPB41L3_ENST00000540638.2_Silent_p.A530A|EPB41L3_ENST00000400111.3_Silent_p.A530A|EPB41L3_ENST00000342933.3_Silent_p.A699A|EPB41L3_ENST00000544123.1_Silent_p.A530A|EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000427684.2_5'UTR	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	699	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						TCTCCCCGTCGGCTGCGGTGT	0.532000													24	30					0	0	0.005443	0	0
LPL	4023	broad.mit.edu	37	8	19805791	19805791	+	Silent	SNP	C	C	T	rs114726797	by1000genomes	TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:19805791C>T	ENST00000311322.8	+	2	659	c.189C>T	c.(187-189)tcC>tcT	p.S63S	LPL_ENST00000521994.1_3'UTR	NM_000237.2	NP_000228.1	P06858	LIPL_HUMAN	lipoprotein lipase	63					fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	36				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	TAGCAGAGTCCGTGGCTACCT	0.502000													88	15					0	0	0.003610	0	0
RALGAPB	57148	broad.mit.edu	37	20	37154131	37154131	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:37154131C>T	ENST00000262879.6	+	12	2156	c.1872C>T	c.(1870-1872)ctC>ctT	p.L624L	RALGAPB_ENST00000397042.3_Silent_p.L624L|RALGAPB_ENST00000397040.1_Silent_p.L624L|RALGAPB_ENST00000397038.1_Silent_p.L402L			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	624					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TGTTGCCCCTCCCTCATCATT	0.318000													42	85					0	0	0.003610	0	0
THAP7-AS1	439931	broad.mit.edu	37	22	21363718	21363718	+	RNA	SNP	C	C	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:21363718C>G	ENST00000452284.1	+	0	1385				TUBA3FP_ENST00000422086.1_RNA|THAP7-AS1_ENST00000436079.1_RNA	NR_027051.1																						ATGAGGAAGCCCTGCAGTCCC	0.597000													10	19					0	0	0.001368	0	0
SLC38A1	81539	broad.mit.edu	37	12	46591600	46591600	+	Splice_Site	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:46591600C>T	ENST00000398637.5	-	16	1959	c.1264_splice	c.e16-1	p.G422_splice	SLC38A1_ENST00000439706.1_Splice_Site_p.G422_splice|SLC38A1_ENST00000546893.1_Splice_Site_p.G422_splice|SLC38A1_ENST00000549049.1_Splice_Site_p.G422_splice|SLC38A1_ENST00000552197.1_Splice_Site_p.G422_splice	NM_001077484.1|NM_001278387.1|NM_001278388.1|NM_001278389.1|NM_030674.3	NP_001070952.1|NP_001265316.1|NP_001265317.1|NP_001265318.1|NP_109599.3	Q9H2H9	S38A1_HUMAN	solute carrier family 38, member 1	422					cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			NS(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(2)	23	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			AGATGTAACTCCTGTAAAATA	0.343000													16	38					0	0	0.003163	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719847	140719847	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:140719847C>T	ENST00000394576.2	+	1	1309	c.1309C>T	c.(1309-1311)Cac>Tac	p.H437Y	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGGATGCTCACATTTTGCT	0.532000													39	26					0	0	0.001287	0	0
ZBTB12	221527	broad.mit.edu	37	6	31868369	31868369	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:31868369G>A	ENST00000375527.2	-	2	889	c.714C>T	c.(712-714)tcC>tcT	p.S238S	C2_ENST00000469372.1_Intron	NM_181842.2	NP_862825.1	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	238	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)|prostate(1)|skin(1)	10						GGCCACCCACGGAGCCTCCAA	0.662000													127	327					0	0	0.003610	0	0
GIMAP8	155038	broad.mit.edu	37	7	150171146	150171146	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:150171146G>A	ENST00000307271.3	+	4	1303	c.729G>A	c.(727-729)ccG>ccA	p.P243P		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	243						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		AGCAGAATCCGGGGACATCAG	0.552000													47	129					0	0	0.003610	0	0
KRT5	3852	broad.mit.edu	37	12	52908823	52908823	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:52908823C>T	ENST00000252242.4	-	9	2066	c.1676G>A	c.(1675-1677)cGa>cAa	p.R559Q		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	559	Ser-rich.|Tail.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		CCCCAGCCCTCGGCCACTGCT	0.622000													18	38					0	0	0.005443	0	0
ZNF618	114991	broad.mit.edu	37	9	116770806	116770806	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:116770806C>T	ENST00000288466.7	+	8	729	c.630C>T	c.(628-630)ccC>ccT	p.P210P	ZNF618_ENST00000374126.5_Silent_p.P242P	NM_133374.2	NP_588615.2	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	308					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|lung(10)|urinary_tract(1)	16						AGGAGGAGCCCCCGGAGCCAT	0.652000													12	32					0	0	0.001855	0	0
NXN	64359	broad.mit.edu	37	17	726978	726978	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:726978G>A	ENST00000336868.3	-	3	597	c.506C>T	c.(505-507)cCc>cTc	p.P169L	NXN_ENST00000537628.2_5'UTR|NXN_ENST00000577098.1_5'UTR|NXN_ENST00000575801.1_Missense_Mutation_p.P61L	NM_022463.4	NP_071908.2	Q6DKJ4	NXN_HUMAN	nucleoredoxin	169	Thioredoxin.				cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)		TTCCCTGAAGGGTTTCGGTCC	0.547000													17	25					0	0	0.000958	0	0
PAX8	7849	broad.mit.edu	37	2	113994298	113994298	+	Splice_Site	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:113994298C>T	ENST00000429538.3	-	8	972	c.777_splice	c.e8-1	p.G260_splice	AC016683.6_ENST00000437551.1_RNA|AC016683.6_ENST00000556070.1_RNA|AC016683.6_ENST00000445745.1_RNA|PAX8_ENST00000397647.3_Intron|PAX8_ENST00000263334.5_Splice_Site_p.G260_splice|AC016683.6_ENST00000451179.1_RNA|PAX8_ENST00000348715.5_Splice_Site_p.G260_splice|AC016683.6_ENST00000333145.5_RNA|AC016683.6_ENST00000436293.2_RNA|AC016683.6_ENST00000422956.1_RNA|AC016683.6_ENST00000456685.1_RNA|PAX8_ENST00000263335.7_Intron|AC016683.6_ENST00000553869.2_RNA	NM_003466.3	NP_003457.1	Q06710	PAX8_HUMAN	paired box 8	260					branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity		PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						GGGTAGAGGCCCTGGGGAGCA	0.622000			T	PPARG	follicular thyroid		Thyroid dysgenesis						4	5					0	0	0.000248	0	0
LRP1B	53353	broad.mit.edu	37	2	141072609	141072609	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:141072609C>T	ENST00000389484.3	-	83	13671	c.12700G>A	c.(12700-12702)Gat>Aat	p.D4234N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4234	EGF-like 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CACCTCAAATCACCTTTCTCA	0.388000										TSP Lung(27;0.18)			14	10					0	0	0.002450	0	0
CHD6	84181	broad.mit.edu	37	20	40102057	40102057	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:40102057G>A	ENST00000373233.3	-	17	2746	c.2569C>T	c.(2569-2571)Ctg>Ttg	p.L857L	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	857	Helicase C-terminal.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CTGGTGCACAGAAGAAAGACA	0.517000													25	58					0	0	0.003954	0	0
LRP2	4036	broad.mit.edu	37	2	170013888	170013888	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:170013888G>A	ENST00000263816.3	-	64	12297	c.12012C>T	c.(12010-12012)tcC>tcT	p.S4004S		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4004	EGF-like 14.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TACCTAGACAGGAGGTTCTGT	0.363000													5	14					0	0	0.000602	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21795941	21795941	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr14:21795941A>G	ENST00000206660.6	+	17	2870	c.2870A>G	c.(2869-2871)gAg>gGg	p.E957G	RPGRIP1_ENST00000556336.1_Missense_Mutation_p.E614G|RPGRIP1_ENST00000400017.2_Missense_Mutation_p.E957G|RPGRIP1_ENST00000307974.4_Missense_Mutation_p.E316G|RPGRIP1_ENST00000382933.4_Missense_Mutation_p.E283G|RPGRIP1_ENST00000557771.1_Missense_Mutation_p.E919G			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	957	Interaction with RPGR.				response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		TCATCTGAAGAGGAAAAGGCT	0.463000													14	8					0	0	0.003163	0	0
MUC4	4585	broad.mit.edu	37	3	195491943	195491943	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:195491943C>T	ENST00000463781.3	-	10	14308	c.13849G>A	c.(13849-13851)Gga>Aga	p.G4617R	MUC4_ENST00000475231.1_Missense_Mutation_p.G4565R|MUC4_ENST00000346145.4_Missense_Mutation_p.G381R|MUC4_ENST00000349607.4_Missense_Mutation_p.G330R	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1374					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CACACGCCTCCTCGCCAAGAG	0.657000													9	29					0	0	0.004482	0	0
CAND1	55832	broad.mit.edu	37	12	67699385	67699385	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:67699385C>T	ENST00000545606.1	+	10	2374	c.1937C>T	c.(1936-1938)cCt>cTt	p.P646L		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	646					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		GATTTGAGGCCTGTTCTGGGA	0.393000													40	64					0	0	0.002222	0	0
FAM46D	169966	broad.mit.edu	37	X	79698282	79698282	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chrX:79698282G>A	ENST00000538312.1	+	5	578	c.244G>A	c.(244-246)Gat>Aat	p.D82N	FAM46D_ENST00000308293.5_Missense_Mutation_p.D82N	NM_001170574.1	NP_001164045.1	Q8NEK8	FA46D_HUMAN	family with sequence similarity 46, member D	82										kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23						CAGCTATAAGGATCTGGACGT	0.383000													11	3					0	0	0.000978	0	0
SAP130	79595	broad.mit.edu	37	2	128767934	128767934	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:128767934G>A	ENST00000357702.5	-	7	987	c.856C>T	c.(856-858)Cct>Tct	p.P286S	SAP130_ENST00000259235.3_Missense_Mutation_p.P286S|SAP130_ENST00000259234.6_Missense_Mutation_p.P260S	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa	286					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		ACAGCAGGAGGGATGGCATTG	0.448000													9	46					0	0	0.000443	0	0
MYOM3	127294	broad.mit.edu	37	1	24419474	24419474	+	Silent	SNP	G	G	A	rs143871016		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:24419474G>A	ENST00000330966.7	-	10	1218	c.1056C>T	c.(1054-1056)ttC>ttT	p.F352F	MYOM3_ENST00000374434.3_Silent_p.F351F|MYOM3_ENST00000329601.7_Silent_p.F351F|MYOM3_ENST00000475306.1_5'UTR			Q5VTT5	MYOM3_HUMAN	myomesin 3	351	Ig-like C2-type 2.							p.F351F(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CCCGGGGTCCGAAGGGCGAGG	0.642000													16	23					0	0	0.003163	0	0
OR13F1	138805	broad.mit.edu	37	9	107266751	107266751	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:107266751G>A	ENST00000334726.2	+	1	297	c.208G>A	c.(208-210)Gac>Aac	p.D70N		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						CTCCTTTCTGGACATCTGGTA	0.483000													48	121					0	0	0.003610	0	0
SLC37A1	54020	broad.mit.edu	37	21	43963548	43963548	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr21:43963548G>A	ENST00000352133.2	+	8	1548	c.566G>A	c.(565-567)aGa>aAa	p.R189K	SLC37A1_ENST00000398341.3_Missense_Mutation_p.R189K			P57057	GLPT_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 1	189					carbohydrate transport|transmembrane transport	integral to membrane				breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|liver(2)|lung(3)	15						TGCTGCAGGAGAGGTTTGATT	0.567000													74	142					0	0	0.003610	0	0
MUSK	4593	broad.mit.edu	37	9	113547266	113547266	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:113547266G>A	ENST00000416899.2	+	10	1658	c.1532G>A	c.(1531-1533)cGa>cAa	p.R511Q	MUSK_ENST00000374448.4_Missense_Mutation_p.R519Q|MUSK_ENST00000189978.5_Missense_Mutation_p.R519Q|MUSK_ENST00000374438.1_Intron			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	519					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.R519Q(1)		breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						TATTGCTGCCGAAGAAGAAAA	0.358000													47	109					0	0	0.003610	0	0
KIF21A	55605	broad.mit.edu	37	12	39698727	39698727	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:39698727C>T	ENST00000395670.3	-	34	4878	c.4459G>A	c.(4459-4461)Gga>Aga	p.G1487R	KIF21A_ENST00000541463.2_Missense_Mutation_p.G1433R|KIF21A_ENST00000544797.2_Missense_Mutation_p.G1449R|KIF21A_ENST00000361961.3_Missense_Mutation_p.G1473R|KIF21A_ENST00000361418.5_Missense_Mutation_p.G1486R			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1486					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				GTTAACTTTCCTGTAGACTGA	0.353000													8	15					0	0	0.003080	0	0
TRBV11-1	28582	broad.mit.edu	37	7	142224030	142224030	+	RNA	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:142224030G>A	ENST00000390367.3	-	0	153																											AGCATGGCCAGAAATAGGATC	0.488000													39	40					0	0	0.001485	0	0
DMP1	1758	broad.mit.edu	37	4	88584265	88584265	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:88584265G>A	ENST00000339673.6	+	6	1434	c.1335G>A	c.(1333-1335)gaG>gaA	p.E445E	RP11-742B18.1_ENST00000507894.1_RNA|RP11-742B18.1_ENST00000506480.1_RNA|DMP1_ENST00000282479.7_Silent_p.E429E	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	445					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		GTCAGAGCGAGGAAAGCCATT	0.537000													27	40					0	0	0.004656	0	0
WWC1	23286	broad.mit.edu	37	5	167896006	167896006	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:167896006C>T	ENST00000265293.4	+	23	3828	c.3326C>T	c.(3325-3327)tCt>tTt	p.S1109F	WWC1_ENST00000521089.1_Missense_Mutation_p.S1115F	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	1109	Interaction with histone H3.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		CCAGCTCTCTCTGCAGATGAC	0.458000													41	26					0	0	0.003214	0	0
CECR6	27439	broad.mit.edu	37	22	17601206	17601206	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:17601206G>A	ENST00000331437.3	-	1	937	c.812C>T	c.(811-813)gCg>gTg	p.A271V	CECR6_ENST00000399875.1_Intron	NM_031890.3	NP_114096.1	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	271	Ala-rich.									haematopoietic_and_lymphoid_tissue(1)	1		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		CAGGGGCGGCGCGGCGTGGTG	0.801000													6	32					0	0	0.001984	0	0
NRSN2	80023	broad.mit.edu	37	20	334186	334186	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:334186C>T	ENST00000382291.3	+	4	762	c.522C>T	c.(520-522)ttC>ttT	p.F174F	NRSN2_ENST00000382285.2_Silent_p.F174F|NRSN2_ENST00000492242.1_3'UTR	NM_024958.2	NP_079234.1	Q9GZP1	NRSN2_HUMAN	neurensin 2	174						integral to membrane|plasma membrane|transport vesicle				endometrium(1)|large_intestine(2)|lung(4)|urinary_tract(1)	8		all_cancers(10;0.0834)				CACCCATTTTCCGCAATGCCA	0.622000													48	89					0	0	0.003610	0	0
PPT2-EGFL8	100532746	broad.mit.edu	37	6	32123681	32123681	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:32123681C>A	ENST00000422437.1	+	5	658	c.467C>A	c.(466-468)tCc>tAc	p.S156Y	PPT2_ENST00000375143.2_Missense_Mutation_p.S156Y|PPT2_ENST00000324816.6_Missense_Mutation_p.S156Y|PPT2_ENST00000445576.2_Missense_Mutation_p.S156Y|PPT2_ENST00000375137.2_Missense_Mutation_p.S156Y|PPT2_ENST00000437001.2_Missense_Mutation_p.S33Y|PPT2-EGFL8_ENST00000453656.2_3'UTR|PPT2_ENST00000361568.2_Missense_Mutation_p.S162Y|PPT2_ENST00000493548.1_3'UTR|PPT2_ENST00000395523.1_Missense_Mutation_p.S156Y																							TTCCCCACCTCCATGCGGTCT	0.532000													184	405					4.24805e-90	1.02304e-89	0.003610	1	0
TTN	7273	broad.mit.edu	37	2	179614852	179614852	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:179614852G>A	ENST00000360870.5	-	46	12497	c.12275C>T	c.(12274-12276)cCc>cTc	p.P4092L	TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	3468							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCTCCAGAGGGAGGAACTGG	0.423000													6	15					0	0	0.001168	0	0
RPL10	6134	broad.mit.edu	37	X	153628162	153628162	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chrX:153628162T>C	ENST00000424325.2	+	5	397	c.209T>C	c.(208-210)aTt>aCt	p.I70T	RPL10_ENST00000406022.2_Missense_Mutation_p.I19T|RPL10_ENST00000369817.2_Missense_Mutation_p.I70T	NM_001256577.1|NM_001256580.1|NM_006013.3	NP_001243506.1|NP_001243509.1|NP_006004.2	P27635	RL10_HUMAN	ribosomal protein L10	70					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|endoplasmic reticulum	structural constituent of ribosome			large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCTGCCCGAATTTGTGCCAAT	0.493000													57	18					0	0	0.003610	0	0
PYGB	5834	broad.mit.edu	37	20	25277073	25277073	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:25277073G>A	ENST00000216962.4	+	20	2557	c.2447G>A	c.(2446-2448)cGg>cAg	p.R816Q	PYGB_ENST00000471359.1_3'UTR|ABHD12_ENST00000376542.3_Intron	NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	816					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	TCCAGTGACCGGACCATCACG	0.607000													34	53					0	0	0.003271	0	0
LMBR1	64327	broad.mit.edu	37	7	156549148	156549148	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:156549148G>A	ENST00000353442.4	-	9	932	c.696C>T	c.(694-696)gaC>gaT	p.D232D	LMBR1_ENST00000359422.4_Silent_p.D80D|LMBR1_ENST00000354505.4_Silent_p.D232D|LMBR1_ENST00000540390.1_Silent_p.D211D	NM_022458.3	NP_071903.2	Q8WVP7	LMBR1_HUMAN	limb development membrane protein 1	232						integral to membrane	receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	18	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)		GTTCATCCAGGTCTTCAAGAA	0.284000													21	78					0	0	0.003330	0	0
THSD7A	221981	broad.mit.edu	37	7	11415488	11415488	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:11415488G>A	ENST00000423059.3	-	28	5158	c.4907C>T	c.(4906-4908)cCc>cTc	p.P1636L	AC004538.3_ENST00000445839.1_RNA|AC004538.3_ENST00000428967.1_RNA|AC004538.3_ENST00000599875.1_RNA|AC004538.3_ENST00000421121.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1636						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CCTTCTTTGGGGTTTCTTTGG	0.353000										HNSCC(18;0.044)			26	94					0	0	0.001512	0	0
KIAA1804	84451	broad.mit.edu	37	1	233507856	233507856	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:233507856C>T	ENST00000366624.3	+	6	1886	c.1625C>T	c.(1624-1626)tCc>tTc	p.S542F	MLK4_ENST00000366623.3_Missense_Mutation_p.S542F	NM_032435.2	NP_115811.2																					AGCAGCAGTTCCAGTCCCCCG	0.567000													46	100					0	0	0.003610	0	0
LPL	4023	broad.mit.edu	37	8	19805790	19805790	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:19805790C>T	ENST00000311322.8	+	2	658	c.188C>T	c.(187-189)tCc>tTc	p.S63F	LPL_ENST00000521994.1_3'UTR	NM_000237.2	NP_000228.1	P06858	LIPL_HUMAN	lipoprotein lipase	63					fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	36				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	GTAGCAGAGTCCGTGGCTACC	0.502000													87	15					0	0	0.003610	0	0
ARPP21	10777	broad.mit.edu	37	3	35725273	35725273	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:35725273C>T	ENST00000187397.4	+	5	683	c.227C>T	c.(226-228)tCt>tTt	p.S76F	ARPP21_ENST00000428373.1_Missense_Mutation_p.S76F|ARPP21_ENST00000458225.1_Missense_Mutation_p.S76F|ARPP21_ENST00000444190.1_Missense_Mutation_p.S76F|ARPP21_ENST00000396482.2_Missense_Mutation_p.S76F|ARPP21_ENST00000337271.5_Missense_Mutation_p.S76F|ARPP21_ENST00000412048.1_Missense_Mutation_p.S76F|ARPP21_ENST00000441454.1_Missense_Mutation_p.S76F|ARPP21_ENST00000417925.1_Missense_Mutation_p.S76F|ARPP21_ENST00000438071.1_Missense_Mutation_p.S76F|ARPP21_ENST00000427542.1_Missense_Mutation_p.S76F|ARPP21_ENST00000432682.1_Missense_Mutation_p.S76F|ARPP21_ENST00000436702.1_Missense_Mutation_p.S76F|ARPP21_ENST00000396481.2_Missense_Mutation_p.S76F|ARPP21_ENST00000474696.1_Missense_Mutation_p.S76F	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	76						cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						GAGGAATCTTCTGCCAGACCA	0.448000													5	6					0	0	0.000602	0	0
COL5A2	1290	broad.mit.edu	37	2	189932758	189932758	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:189932758C>T	ENST00000374866.3	-	21	1658	c.1384G>A	c.(1384-1386)Gga>Aga	p.G462R		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	462					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCTCGAATTCCCTGAGGACCA	0.498000													46	58					0	0	0.003610	0	0
CNGA2	1260	broad.mit.edu	37	X	150912707	150912707	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chrX:150912707C>T	ENST00000329903.4	+	6	1765	c.1732C>T	c.(1732-1734)Ctc>Ttc	p.L578F		NM_005140.1	NP_005131.1	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	578					response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(4)|endometrium(4)|large_intestine(5)|lung(34)|prostate(2)	49	Acute lymphoblastic leukemia(192;6.56e-05)					TCGGGAGATCCTCATGAAGGA	0.522000													80	35					0	0	0.003610	0	0
SREBF1	6720	broad.mit.edu	37	17	17719921	17719921	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:17719921G>A	ENST00000355815.4	-	11	2156	c.1987C>T	c.(1987-1989)Cgt>Tgt	p.R663C	SREBF1_ENST00000261646.5_Missense_Mutation_p.R633C|SREBF1_ENST00000338854.5_Missense_Mutation_p.R633C|SREBF1_ENST00000395757.1_Missense_Mutation_p.R379C	NM_001005291.2	NP_001005291.1	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription factor 1	633					cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	14						AGCAGGTGACGGATGAGGTTC	0.716000													9	5					0	0	0.004482	0	0
RTCB	51493	broad.mit.edu	37	22	32804821	32804821	+	Splice_Site	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:32804821C>T	ENST00000216038.5	-	2	192		c.e2-1		RTCB_ENST00000451746.2_Splice_Site	NM_014306.4	NP_055121.1			RNA 2',3'-cyclic phosphate and 5'-OH ligase																		CACCTTCAACCTAGTACCAAG	0.418000													10	20					0	0	0.000673	0	0
MRPS31P5	100887750	broad.mit.edu	37	13	52744146	52744146	+	RNA	SNP	T	T	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr13:52744146T>G	ENST00000451298.1	-	0	2175				RP11-64P12.8_ENST00000606031.1_RNA																							AGCAGTGGAATTATTTGGATT	0.348000													6	12					0	0	0.003080	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120348898	120348898	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:120348898C>T	ENST00000397843.2	+	37	3732	c.3566C>T	c.(3565-3567)tCg>tTg	p.S1189L	ARHGEF12_ENST00000532993.1_Missense_Mutation_p.S1086L|ARHGEF12_ENST00000356641.3_Missense_Mutation_p.S1170L	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1189					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		ACCTTAATATCGTCAAAACCT	0.373000			T	MLL	AML								14	14					0	0	0.001855	0	0
AOX1	316	broad.mit.edu	37	2	201460031	201460031	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:201460031G>A	ENST00000374700.2	+	3	381	c.140G>A	c.(139-141)gGa>gAa	p.G47E		NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	47	2Fe-2S ferredoxin-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TGTGGAGGAGGAGGCTGTGGT	0.423000													7	32					0	0	0.003080	0	0
C1orf127	148345	broad.mit.edu	37	1	11017747	11017747	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:11017747C>A	ENST00000377004.4	-	7	618	c.619G>T	c.(619-621)Gga>Tga	p.G207*	C1orf127_ENST00000377008.4_Nonsense_Mutation_p.G58*	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	58										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		ACATACAGTCCCATCAGGCTG	0.582000													40	79					4.32679e-17	1.03009e-16	0.001485	1	0
TLR8	51311	broad.mit.edu	37	X	12938041	12938041	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chrX:12938041C>T	ENST00000218032.6	+	2	969	c.882C>T	c.(880-882)ctC>ctT	p.L294L	TLR8_ENST00000311912.5_Silent_p.L312L	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	294					cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						ACCTAAACCTCTCTAGCACTT	0.408000													47	9					0	0	0.003610	0	0
MYT1	4661	broad.mit.edu	37	20	62838983	62838983	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:62838983C>T	ENST00000536311.1	+	7	798	c.434C>T	c.(433-435)cCc>cTc	p.P145L	MYT1_ENST00000328439.1_Missense_Mutation_p.P145L|MYT1_ENST00000360149.4_Intron			Q01538	MYT1_HUMAN	myelin transcription factor 1	145					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GGATCCAACCCCATCGGCAGC	0.557000													41	94					0	0	0.002222	0	0
ADGRG6	57211	broad.mit.edu	37	6	142721671	142721671	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:142721671C>T	ENST00000230173.6	+	11	2093	c.1617C>T	c.(1615-1617)atC>atT	p.I539I	GPR126_ENST00000367609.3_Silent_p.I539I|GPR126_ENST00000367608.2_Silent_p.I511I|GPR126_ENST00000296932.8_Silent_p.I511I	NM_020455.5	NP_065188.4	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	539					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		GGCCATCTATCCAACCTTCTG	0.413000													11	7					0	0	0.001368	0	0
DGCR6L	85359	broad.mit.edu	37	22	20302212	20302212	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:20302212G>A	ENST00000248879.3	-	5	740	c.649C>T	c.(649-651)Cct>Tct	p.P217S	DGCR6L_ENST00000405465.3_Missense_Mutation_p.P179S	NM_033257.3	NP_150282.2	Q9BY27	DGC6L_HUMAN	DiGeorge syndrome critical region gene 6-like	217						nucleus				endometrium(1)|kidney(1)|lung(2)|stomach(1)	5	Colorectal(54;0.0993)					GGTGGGACAGGGCTGCCTTTC	0.652000													12	32					0	0	0.000958	0	0
PILRB	29990	broad.mit.edu	37	7	99956403	99956403	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:99956403C>T	ENST00000310771.4	+	16	2651	c.155C>T	c.(154-156)cCc>cTc	p.P52L	PILRB_ENST00000444874.1_Intron|PILRB_ENST00000448382.1_Intron|PILRB_ENST00000444073.1_Missense_Mutation_p.P52L|PILRB_ENST00000452089.1_Missense_Mutation_p.P52L			Q9UKJ0	PILRB_HUMAN	paired immunoglobin-like type 2 receptor beta	52	Ig-like V-type.				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTGGAAATCCCCTTCTCCTTC	0.542000													20	28					0	0	0.001882	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141356	143141356	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:143141356T>C	ENST00000332690.1	+	1	811	c.811T>C	c.(811-813)Ttt>Ctt	p.F271L	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	271					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					TGCAGGTATTTTTCCACCTCT	0.488000													16	325					0	0	0.006122	0	0
CDC42SE2	56990	broad.mit.edu	37	5	130721235	130721235	+	Splice_Site	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:130721235G>A	ENST00000505065.1	+	4	575		c.e4-1		CDC42SE2_ENST00000395246.1_Splice_Site|CDC42SE2_ENST00000360515.3_Splice_Site|CDC42SE2_ENST00000503291.1_Splice_Site			Q9NRR3	C42S2_HUMAN	CDC42 small effector 2						phagocytosis|regulation of cell shape|regulation of signal transduction	cell projection|cytoplasm|cytoskeleton|phagocytic cup	protein binding|structural molecule activity			breast(1)|large_intestine(1)|skin(1)	3		all_cancers(142;0.0525)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCATATTTTAGAAAAGGCGAC	0.383000													26	15					0	0	0.004656	0	0
OR4D1	26689	broad.mit.edu	37	17	56233094	56233094	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:56233094C>T	ENST00000268912.5	+	1	601	c.580C>T	c.(580-582)Ctc>Ttc	p.L194F		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						TGATACCTCCCTCCTGGAGTT	0.498000													30	48					0	0	0.002096	0	0
ETS2	2114	broad.mit.edu	37	21	40191545	40191545	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr21:40191545C>T	ENST00000360214.3	+	9	1390	c.930C>T	c.(928-930)tcC>tcT	p.S310S	ETS2_ENST00000360938.3_Silent_p.S310S	NM_001256295.1	NP_001243224.1	P15036	ETS2_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 2	310					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				GGGTTCCTTCCTTCGAGAGCT	0.552000													13	31					0	0	0.001855	0	0
SAP130	79595	broad.mit.edu	37	2	128767935	128767935	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:128767935G>A	ENST00000357702.5	-	7	986	c.855C>T	c.(853-855)atC>atT	p.I285I	SAP130_ENST00000259235.3_Silent_p.I285I|SAP130_ENST00000259234.6_Silent_p.I259I	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa	285					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		CAGCAGGAGGGATGGCATTGG	0.448000													9	46					0	0	0.000443	0	0
MEIS2	4212	broad.mit.edu	37	15	37184583	37184583	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:37184583G>A	ENST00000338564.5	-	13	1650	c.1204C>T	c.(1204-1206)Cct>Tct	p.P402S	MEIS2_ENST00000397620.2_3'UTR|MEIS2_ENST00000382766.2_Missense_Mutation_p.P402S|MEIS2_ENST00000559085.1_3'UTR|MEIS2_ENST00000557796.2_3'UTR|MEIS2_ENST00000444725.1_3'UTR|MEIS2_ENST00000424352.2_3'UTR|MEIS2_ENST00000397624.3_3'UTR|MEIS2_ENST00000340545.5_3'UTR|MEIS2_ENST00000561208.1_Missense_Mutation_p.P409S|MEIS2_ENST00000219869.9_3'UTR	NM_001220482.1	NP_001207411.1	O14770	MEIS2_HUMAN	Meis homeobox 2	409					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	36		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		ATCTGGGGAGGAGTGTAACTT	0.512000													124	84					0	0	0.003610	0	0
CDHR5	53841	broad.mit.edu	37	11	618706	618706	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:618706C>T	ENST00000358353.3	-	14	2175	c.1853G>A	c.(1852-1854)gGa>gAa	p.G618E	CDHR5_ENST00000397542.2_Missense_Mutation_p.G618E|CDHR5_ENST00000349570.7_Intron			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	618	4 X 31 AA approximate tandem repeats.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						GGTGCTGGTTCCCATACCGGG	0.657000													58	63					0	0	0.003610	0	0
BAI3	577	broad.mit.edu	37	6	70070763	70070763	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:70070763C>T	ENST00000370598.1	+	29	4419	c.3598C>T	c.(3598-3600)Ctt>Ttt	p.L1200F	BAI3_ENST00000238918.8_Missense_Mutation_p.L406F|BAI3_ENST00000546190.1_Missense_Mutation_p.L164F	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1200					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				ACTCACAGTTCTTCATAAGGA	0.338000													9	33					0	0	0.004482	0	0
DEFB110	245913	broad.mit.edu	37	6	49986740	49986740	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:49986740T>A	ENST00000371148.2	-	2	199	c.154A>T	c.(154-156)Agg>Tgg	p.R52W	DEFB110_ENST00000393660.2_Intron	NM_001037497.1	NP_001032586.1	Q30KQ9	DB110_HUMAN	defensin, beta 110 locus	52					defense response to bacterium	extracellular region				endometrium(1)|lung(1)|ovary(1)	3	Lung NSC(77;0.042)					TAAGCAATCCTAATTTCATTT	0.408000													6	22					0	0	0.001984	0	0
PLCH2	9651	broad.mit.edu	37	1	2436369	2436369	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:2436369C>T	ENST00000378486.3	+	22	4242	c.3968C>T	c.(3967-3969)cCg>cTg	p.P1323L	PLCH2_ENST00000378488.3_Missense_Mutation_p.P1287L|PLCH2_ENST00000378483.2_3'UTR|PLCH2_ENST00000449969.1_3'UTR|PLCH2_ENST00000419816.2_Missense_Mutation_p.P1323L	NM_014638.2	NP_055453.2	O75038	PLCH2_HUMAN	phospholipase C, eta 2	1323					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		AGCCTGGGCCCGGCTGGGGAG	0.721000													6	9					0	0	0.003080	0	0
IRF7	3665	broad.mit.edu	37	11	612695	612695	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:612695G>A	ENST00000397566.1	-	9	1910	c.1501C>T	c.(1501-1503)Ctc>Ttc	p.L501F	IRF7_ENST00000397574.2_Missense_Mutation_p.L488F|IRF7_ENST00000397562.3_Missense_Mutation_p.L195F|IRF7_ENST00000397570.1_Missense_Mutation_p.L459F|IRF7_ENST00000525445.1_Missense_Mutation_p.L382F|IRF7_ENST00000330243.5_Missense_Mutation_p.L501F|IRF7_ENST00000348655.6_Missense_Mutation_p.L459F	NM_004031.2	NP_004022.2	Q92985	IRF7_HUMAN	interferon regulatory factor 7	488					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCGTCATAGAGGCTGTTGGCG	0.597000													43	23					0	0	0.003610	0	0
ATG2A	23130	broad.mit.edu	37	11	64677518	64677518	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:64677518G>A	ENST00000421419.2	-	13	1971	c.1857C>T	c.(1855-1857)ggC>ggT	p.G619G	ATG2A_ENST00000377264.3_Silent_p.G619G			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	619							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						TCACCAGCAGGCCGGCTGGAG	0.731000													15	6					0	0	0.004007	0	0
DPY19L3	147991	broad.mit.edu	37	19	32971433	32971433	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:32971433C>T	ENST00000342179.5	+	18	2174	c.1959C>T	c.(1957-1959)ctC>ctT	p.L653L	DPY19L3_ENST00000586987.1_Silent_p.L653L|DPY19L3_ENST00000392250.2_Silent_p.L653L	NM_207325.2	NP_997208.2	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	653						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					GCTGCCGACTCCGGGACCTGC	0.607000													30	44					0	0	0.002096	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993591	140993591	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chrX:140993591C>T	ENST00000285879.4	+	4	687	c.401C>T	c.(400-402)tCc>tTc	p.S134F	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	134							protein binding	p.S134F(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGCGAGTTCCTTCTTCTCC	0.502000										HNSCC(15;0.026)			54	27					0	0	0.003610	0	0
ATF6	22926	broad.mit.edu	37	1	161816269	161816269	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:161816269C>T	ENST00000367942.3	+	10	1285	c.1218C>T	c.(1216-1218)aaC>aaT	p.N406N	ATF6_ENST00000476437.1_3'UTR	NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	406					positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			GGAGAATGAACCCTAGTGTGA	0.403000													22	29					0	0	0.002299	0	0
FCAR	2204	broad.mit.edu	37	19	55399609	55399609	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:55399609G>C	ENST00000355524.3	+	4	607	c.597G>C	c.(595-597)agG>agC	p.R199S	FCAR_ENST00000345937.4_Intron|FCAR_ENST00000469767.1_Missense_Mutation_p.R199S|FCAR_ENST00000391726.3_Intron|FCAR_ENST00000359272.4_Missense_Mutation_p.R187S|FCAR_ENST00000391724.3_Intron|FCAR_ENST00000391723.3_Intron|FCAR_ENST00000482092.2_Intron|FCAR_ENST00000353758.4_Missense_Mutation_p.R90S|FCAR_ENST00000391725.3_Intron	NM_002000.2	NP_001991.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for	199	Ig-like C2-type 2.				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		GGTACAACAGGAGCCCCTACC	0.587000													7	20					0	0	0.001984	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414902	14414902	+	RNA	SNP	G	G	A	rs2821609	by1000genomes	TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr21:14414902G>A	ENST00000507941.1	+	0	95																											CCAGCTTGACGTCCTTGATGG	0.443000													7	41					0	0	0.004482	0	0
DMBT1	1755	broad.mit.edu	37	10	124399828	124399828	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:124399828G>A	ENST00000368909.3	+	52	6934	c.6828G>A	c.(6826-6828)gtG>gtA	p.V2276V	DMBT1_ENST00000359586.6_Silent_p.V996V|DMBT1_ENST00000330163.4_Silent_p.V1648V|DMBT1_ENST00000338354.3_Silent_p.V2276V|DMBT1_ENST00000344338.3_Silent_p.V2266V|DMBT1_ENST00000368956.2_Silent_p.V1648V|DMBT1_ENST00000368955.3_Silent_p.V2266V	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2276	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CTTACTACGTGGACCTGAACC	0.478000													53	64					0	0	0.003610	0	0
SLC26A9	115019	broad.mit.edu	37	1	205890930	205890930	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:205890930G>A	ENST00000367135.3	-	17	1932	c.1819C>T	c.(1819-1821)Ccc>Tcc	p.P607S	SLC26A9_ENST00000367134.2_Missense_Mutation_p.P607S|SLC26A9_ENST00000340781.4_Missense_Mutation_p.P607S	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	607	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GGGTCGGTGGGGGGCGCATTC	0.622000													10	23					0	0	0.000978	0	0
ACPT	93650	broad.mit.edu	37	19	51298160	51298160	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:51298160G>A	ENST00000270593.1	+	10	1104	c.1104G>A	c.(1102-1104)ccG>ccA	p.P368P	ACPT_ENST00000270594.3_Silent_p.P275P	NM_033068.2	NP_149059.1	Q9BZG2	PPAT_HUMAN	acid phosphatase, testicular	368						integral to membrane	acid phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(3)	11		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TGACTGCCCCGGCCCGGCCTC	0.692000													37	205					0	0	0.004289	0	0
ZNF117	51351	broad.mit.edu	37	7	64439187	64439187	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:64439187G>A	ENST00000282869.5	-	4	2046	c.762C>T	c.(760-762)tgC>tgT	p.C254C		NM_015852.3	NP_056936.2	Q03924	ZN117_HUMAN	zinc finger protein 117	254						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(1)|skin(1)	22		Lung NSC(55;0.0295)|all_lung(88;0.0691)				AAGCTTTGCCGCATTCTTCAC	0.368000													4	40					0	0	0.000602	0	0
ATG9B	285973	broad.mit.edu	37	7	150721026	150721026	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:150721026G>C	ENST00000605938.1	-	1	560	c.485C>G	c.(484-486)tCc>tGc	p.S162C	ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000444312.1_5'UTR|ATG9B_ENST00000377974.2_Missense_Mutation_p.S162C|ATG9B_ENST00000605952.1_Missense_Mutation_p.S162C	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	162					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGAGTCTTGGGACCCCTCAGG	0.622000													6	8					0	0	0.001984	0	0
AGO4	192670	broad.mit.edu	37	1	36297478	36297478	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:36297478G>A	ENST00000373210.3	+	9	1307	c.1062G>A	c.(1060-1062)atG>atA	p.M354I		NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		CTTCCACAATGATCAAAGCTA	0.433000													20	31					0	0	0.001216	0	0
EPHA3	2042	broad.mit.edu	37	3	89259255	89259255	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:89259255G>A	ENST00000336596.2	+	3	624	c.399G>A	c.(397-399)gtG>gtA	p.V133V	EPHA3_ENST00000452448.2_Silent_p.V133V|EPHA3_ENST00000494014.1_Silent_p.V133V	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	133						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ATCATGGGGTGAAATTTCGAG	0.423000										TSP Lung(6;0.00050)			16	35					0	0	0.003163	0	0
OR5B3	441608	broad.mit.edu	37	11	58170372	58170372	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:58170372C>T	ENST00000309403.2	-	1	510	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGATGGACTTCATTGGACTTA	0.443000													20	12					0	0	0.001216	0	0
KCNMA1	3778	broad.mit.edu	37	10	79163678	79163678	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:79163678G>A	ENST00000286627.5	-	2	1434	c.482C>T	c.(481-483)tCc>tTc	p.S161F	KCNMA1_ENST00000286628.8_Missense_Mutation_p.S161F|KCNMA1_ENST00000354353.5_Missense_Mutation_p.S161F|KCNMA1_ENST00000372440.1_Missense_Mutation_p.S161F|KCNMA1_ENST00000404857.1_Missense_Mutation_p.S161F|KCNMA1_ENST00000406533.3_Missense_Mutation_p.S161F|KCNMA1_ENST00000404771.3_Missense_Mutation_p.S161F|KCNMA1_ENST00000372443.1_Missense_Mutation_p.S161F	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	161					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	GTCCTTCACGGAGGTCATCCA	0.592000													24	17					0	0	0.003954	0	0
CHD5	26038	broad.mit.edu	37	1	6184071	6184071	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:6184071C>T	ENST00000262450.3	-	31	4735	c.4636G>A	c.(4636-4638)Gac>Aac	p.D1546N	CHD5_ENST00000378021.1_Missense_Mutation_p.D403N	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1546					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GTGTTGGGGTCCGAGGAGATC	0.682000													9	20					0	0	0.000443	0	0
CD72	971	broad.mit.edu	37	9	35611858	35611858	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:35611858C>T	ENST00000396757.1	-	8	1057	c.893G>A	c.(892-894)tGg>tAg	p.W298*	CD72_ENST00000259633.4_Nonsense_Mutation_p.W298*|CD72_ENST00000490239.1_5'UTR			P21854	CD72_HUMAN	CD72 molecule	298	C-type lectin.				axon guidance|cell adhesion	integral to plasma membrane	receptor binding|sugar binding|transmembrane receptor activity			large_intestine(5)|liver(1)|lung(6)	12			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GAGGCCAGTCCAATATGAATT	0.428000											OREG0019172	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	40					0	0	0.000958	0	0
MYO1H	283446	broad.mit.edu	37	12	109876414	109876414	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:109876414G>A	ENST00000310903.5	+	23	2341	c.2235G>A	c.(2233-2235)cgG>cgA	p.R745R	MYO1H_ENST00000431443.2_Silent_p.R755R			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						GGGCCGTGCGGATTATCAGAA	0.512000													13	9					0	0	0.003163	0	0
CABP7	164633	broad.mit.edu	37	22	30123650	30123650	+	Splice_Site	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:30123650G>A	ENST00000216144.3	+	2	450		c.e2-1			NM_182527.2	NP_872333.1	Q86V35	CABP7_HUMAN	calcium binding protein 7							Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			lung(1)|skin(3)	4			OV - Ovarian serous cystadenocarcinoma(5;0.00442)|Epithelial(10;0.215)|all cancers(5;0.233)			TCTCTCCTCAGAGATCCGAGA	0.597000													53	151					0	0	0.003610	0	0
VPS13A	23230	broad.mit.edu	37	9	79908348	79908348	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:79908348T>G	ENST00000360280.3	+	32	3691	c.3431T>G	c.(3430-3432)gTg>gGg	p.V1144G	VPS13A_ENST00000376634.4_Missense_Mutation_p.V1144G|VPS13A_ENST00000357409.5_Missense_Mutation_p.V1144G|VPS13A_ENST00000423463.2_3'UTR|VPS13A_ENST00000376636.3_Missense_Mutation_p.V1105G	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	1144					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GATATGAATGTGGTTGACATT	0.299000													27	65					0	0	0.001271	0	0
BIRC6	57448	broad.mit.edu	37	2	32640219	32640219	+	Silent	SNP	T	T	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:32640219T>G	ENST00000421745.2	+	10	1994	c.1860T>G	c.(1858-1860)tcT>tcG	p.S620S		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	620					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					AACTAAATTCTCCTCTGGTAA	0.393000													12	45					0	0	0.001855	0	0
TRAV3	28690	broad.mit.edu	37	14	22192035	22192035	+	RNA	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr14:22192035C>T	ENST00000390425.2	+	0	76																											GTTGCTGGTTCCTCTTCAAGA	0.602000													15	17					0	0	0.002450	0	0
TP63	8626	broad.mit.edu	37	3	189587173	189587173	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:189587173A>G	ENST00000264731.3	+	9	1279	c.1190A>G	c.(1189-1191)gAt>gGt	p.D397G	TP63_ENST00000440651.2_Missense_Mutation_p.D393G|TP63_ENST00000392460.3_Missense_Mutation_p.D397G|TP63_ENST00000392461.3_Missense_Mutation_p.D303G|TP63_ENST00000456148.1_Missense_Mutation_p.D299G|TP63_ENST00000320472.5_Missense_Mutation_p.D397G|TP63_ENST00000418709.2_Missense_Mutation_p.D397G|TP63_ENST00000354600.5_Missense_Mutation_p.D303G|TP63_ENST00000382063.4_Missense_Mutation_p.D312G|TP63_ENST00000437221.1_Missense_Mutation_p.D303G|TP63_ENST00000449992.1_Missense_Mutation_p.D218G|TP63_ENST00000392463.2_Missense_Mutation_p.D303G	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	397	Oligomerization.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		AGATCCCCAGATGATGAACTG	0.418000										HNSCC(45;0.13)			5	39					0	0	0.001168	0	0
NFATC1	4772	broad.mit.edu	37	18	77170939	77170939	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr18:77170939C>T	ENST00000253506.5	+	2	1033	c.664C>T	c.(664-666)Ccc>Tcc	p.P222S	NFATC1_ENST00000586434.1_Missense_Mutation_p.P209S|NFATC1_ENST00000545796.1_Intron|NFATC1_ENST00000542384.1_Missense_Mutation_p.P222S|NFATC1_ENST00000587635.1_Missense_Mutation_p.P222S|NFATC1_ENST00000592223.1_Missense_Mutation_p.P209S|NFATC1_ENST00000318065.5_Missense_Mutation_p.P209S|NFATC1_ENST00000329101.4_Missense_Mutation_p.P209S|NFATC1_ENST00000397790.2_Intron|NFATC1_ENST00000591814.1_Missense_Mutation_p.P222S|NFATC1_ENST00000427363.2_Missense_Mutation_p.P222S	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	222	3 X SP repeats.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GGAGGGCTTTCCCCGCGGGCT	0.706000													55	47					0	0	0.003610	0	0
CCDC136	64753	broad.mit.edu	37	7	128441254	128441254	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:128441254C>T	ENST00000297788.4	+	4	728	c.361C>T	c.(361-363)Cta>Tta	p.L121L	CCDC136_ENST00000464832.1_Silent_p.L171L|CCDC136_ENST00000378685.4_Silent_p.L171L|CCDC136_ENST00000487361.1_Silent_p.L121L	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	121	Glu-rich.					integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						GCTGCGTTCTCTACGGGAGGA	0.463000													5	45					0	0	0.000602	0	0
GIT1	28964	broad.mit.edu	37	17	27903339	27903339	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:27903339G>A	ENST00000225394.3	-	14	1758	c.1510C>T	c.(1510-1512)Cgc>Tgc	p.R504C	RP11-68I3.2_ENST00000581474.1_RNA|GIT1_ENST00000394869.3_Missense_Mutation_p.R513C|GIT1_ENST00000581348.1_Missense_Mutation_p.R513C|GIT1_ENST00000579937.1_Missense_Mutation_p.R504C	NM_014030.3	NP_054749.2	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 1	504					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding			large_intestine(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		AAGGCCTGGCGATCCCTGCGG	0.677000													35	122					0	0	0.004289	0	0
SDF4	51150	broad.mit.edu	37	1	1153003	1153003	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:1153003G>A	ENST00000360001.6	-	7	1240	c.978C>T	c.(976-978)gcC>gcT	p.A326A	SDF4_ENST00000263741.7_3'UTR			Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4	326	EF-hand 6.|Necessary for intracellular retention in Golgi apparatus lumen (By similarity).				cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|identical protein binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		GGTTCTCGTCGGCGACGGCGA	0.637000													37	74					0	0	0.001706	0	0
MUC16	94025	broad.mit.edu	37	19	9090179	9090179	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:9090179C>T	ENST00000397910.4	-	1	1839	c.1636G>A	c.(1636-1638)Gag>Aag	p.E546K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	546	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGGGGTCTCTCTGTTTTCATG	0.527000													36	56					0	0	0.001287	0	0
MCM3AP	8888	broad.mit.edu	37	21	47674388	47674388	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr21:47674388G>A	ENST00000397708.1	-	20	4308	c.4054C>T	c.(4054-4056)Cct>Tct	p.P1352S	MCM3AP_ENST00000291688.1_Missense_Mutation_p.P1352S|MCM3AP-AS1_ENST00000590829.1_RNA|MCM3AP_ENST00000467026.1_5'UTR			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1352					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					TGCCTCCCAGGGAGGTGCTCA	0.597000													17	47					0	0	0.004990	0	0
CCSER1	401145	broad.mit.edu	37	4	91321259	91321259	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:91321259G>A	ENST00000509176.1	+	4	1870	c.1582G>A	c.(1582-1584)Gaa>Aaa	p.E528K	CCSER1_ENST00000432775.2_Missense_Mutation_p.E528K|CCSER1_ENST00000333691.8_Missense_Mutation_p.E528K	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1																		ATTTTTAGAGGAACAGAGTCT	0.353000													9	19					0	0	0.000673	0	0
PNPLA8	50640	broad.mit.edu	37	7	108155291	108155291	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:108155291G>A	ENST00000426128.2	-	2	770	c.645C>T	c.(643-645)ttC>ttT	p.F215F	PNPLA8_ENST00000436062.1_Silent_p.F215F|PNPLA8_ENST00000422087.1_Silent_p.F215F|PNPLA8_ENST00000483879.1_Intron|PNPLA8_ENST00000257694.8_Silent_p.F215F|PNPLA8_ENST00000453144.1_Silent_p.F115F|PNPLA8_ENST00000388728.5_Silent_p.F215F	NM_001256009.1	NP_001242938.1	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	215					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(5)|endometrium(1)|kidney(3)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(3)	29						CCTTACGTTTGAAATATGAAT	0.303000													13	40					0	0	0.001855	0	0
BEGAIN	57596	broad.mit.edu	37	14	101004526	101004526	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr14:101004526C>T	ENST00000556751.1	-	5	4774	c.1370G>A	c.(1369-1371)gGg>gAg	p.G457E	BEGAIN_ENST00000355173.2_Missense_Mutation_p.G521E|BEGAIN_ENST00000443071.2_Missense_Mutation_p.G521E			Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	521						cytoplasm|membrane	protein binding			cervix(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)	14		Melanoma(154;0.212)				GAGCCTGTCCCCGTCCCCCCC	0.736000													14	4					0	0	0.003163	0	0
DNAH3	55567	broad.mit.edu	37	16	21042384	21042384	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:21042384G>A	ENST00000261383.3	-	37	5421	c.5422C>T	c.(5422-5424)Ctg>Ttg	p.L1808L	DNAH3_ENST00000415178.1_Silent_p.L1808L	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1808	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TTGTCATCCAGAACAGTGTTC	0.368000													30	43					0	0	0.001512	0	0
LUC7L	55692	broad.mit.edu	37	16	239276	239276	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:239276G>A	ENST00000293872.8	-	10	1147	c.1037C>T	c.(1036-1038)cCc>cTc	p.P346L	LUC7L_ENST00000337351.4_3'UTR|LUC7L_ENST00000397783.1_3'UTR	NM_201412.1	NP_958815.1	Q9NQ29	LUC7L_HUMAN	LUC7-like (S. cerevisiae)	346	Arg/Ser-rich.						metal ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	11		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				CCAGTCCGGGGGCCCTCGCTC	0.642000													25	105					0	0	0.003954	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182233	57182233	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:57182233C>T	ENST00000504228.1	+	6	2670	c.2565C>T	c.(2563-2565)tcC>tcT	p.S855S	KIAA1211_ENST00000264229.6_Silent_p.S855S|KIAA1211_ENST00000541073.1_Silent_p.S848S			Q6ZU35	K1211_HUMAN	KIAA1211	855										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CCAACTATTCCTTGCGCTTCA	0.562000													26	34					0	0	0.003330	0	0
PPP6C	5537	broad.mit.edu	37	9	127915934	127915934	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:127915934G>A	ENST00000451402.1	-	7	878	c.658C>T	c.(658-660)Cag>Tag	p.Q220*	PPP6C_ENST00000415905.1_Nonsense_Mutation_p.Q161*|PPP6C_ENST00000373546.3_Nonsense_Mutation_p.Q36*|PPP6C_ENST00000373547.4_Nonsense_Mutation_p.Q183*	NM_001123355.1	NP_001116827.1	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit	183					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			NS(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(2)|ovary(1)|skin(3)	14						GGAATTTCCTGATTCCGTTCG	0.428000													20	34					0	0	0.001216	0	0
RANBP2	5903	broad.mit.edu	37	2	109388184	109388184	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:109388184C>T	ENST00000283195.6	+	21	8003	c.7877C>T	c.(7876-7878)tCt>tTt	p.S2626F		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	2626					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						CCTGAAGATTCTCCCTCAGAT	0.358000													89	97					0	0	0.003610	0	0
DNAH3	55567	broad.mit.edu	37	16	21063133	21063133	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:21063133G>A	ENST00000261383.3	-	29	4095	c.4096C>T	c.(4096-4098)Caa>Taa	p.Q1366*	DNAH3_ENST00000415178.1_Nonsense_Mutation_p.Q1366*	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1366	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GAGATCCATTGGAAATCATTC	0.527000													56	76					0	0	0.003610	0	0
POM121L12	285877	broad.mit.edu	37	7	53103403	53103403	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:53103403G>A	ENST00000408890.4	+	1	55	c.39G>A	c.(37-39)ggG>ggA	p.G13G		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	13										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CAGACCTCGGGAACTTCTGGA	0.701000													13	17					0	0	0.001368	0	0
PUS7	54517	broad.mit.edu	37	7	105099683	105099683	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:105099683G>A	ENST00000356362.2	-	15	1995	c.1781C>T	c.(1780-1782)cCc>cTc	p.P594L	PUS7_ENST00000469408.1_Missense_Mutation_p.P594L	NM_019042.3	NP_061915.2	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)	594					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|pancreas(1)|skin(1)	23						TGGAATTTTGGGATCATCATA	0.373000													37	59					0	0	0.001951	0	0
DMTF1	9988	broad.mit.edu	37	7	86817420	86817420	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:86817420G>A	ENST00000414194.2	+	13	2208	c.416G>A	c.(415-417)gGt>gAt	p.G139D	DMTF1_ENST00000432937.2_Missense_Mutation_p.G317D|DMTF1_ENST00000331242.7_Missense_Mutation_p.G405D|DMTF1_ENST00000413276.2_Intron|DMTF1_ENST00000394703.5_Missense_Mutation_p.G405D			Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	405	Interaction with CCND2 (By similarity).|Required for DNA-binding (By similarity).|Required for transcriptional activation (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)	16	Esophageal squamous(14;0.0058)					TTAATAAAAGGTCTTAAACAG	0.433000													17	25					0	0	0.004990	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110478892	110478892	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:110478892C>T	ENST00000378402.5	+	50	8603	c.8499C>T	c.(8497-8499)ttC>ttT	p.F2833F		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2833					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GCATTGGGTTCCCTGGATCAG	0.478000										HNSCC(38;0.096)			20	16					0	0	0.001216	0	0
TROVE2	6738	broad.mit.edu	37	1	193038627	193038627	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:193038627T>C	ENST00000367446.3	+	2	653	c.443T>C	c.(442-444)cTc>cCc	p.L148P	TROVE2_ENST00000460715.2_Intron|TROVE2_ENST00000367443.1_Missense_Mutation_p.L148P|TROVE2_ENST00000367445.3_Missense_Mutation_p.L148P|TROVE2_ENST00000400968.2_Missense_Mutation_p.L148P|TROVE2_ENST00000432079.1_Intron|TROVE2_ENST00000367441.1_Missense_Mutation_p.L148P|TROVE2_ENST00000416058.2_5'UTR|TROVE2_ENST00000367444.3_Missense_Mutation_p.L148P	NM_004600.5	NP_004591.2	P10155	RO60_HUMAN	TROVE domain family, member 2	148	TROVE.				transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding			biliary_tract(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|urinary_tract(1)	21						GGTCGTGCCCTCCGGAAGGCT	0.448000													31	102					0	0	0.003755	0	0
AGPAT3	56894	broad.mit.edu	37	21	45390563	45390563	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr21:45390563C>T	ENST00000398063.2	+	5	1032	c.540C>T	c.(538-540)ttC>ttT	p.F180F	AGPAT3_ENST00000398061.1_Silent_p.F180F|AGPAT3_ENST00000291572.8_Silent_p.F180F|AGPAT3_ENST00000327505.2_Silent_p.F180F|AGPAT3_ENST00000398058.1_Silent_p.F180F|AGPAT3_ENST00000546158.1_Silent_p.F180F|AGPAT3_ENST00000479117.1_3'UTR	NM_001037553.1	NP_001032642.1	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	180					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			large_intestine(4)|lung(5)|ovary(1)|prostate(1)	11				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		GGACGCGCTTCACGGAGACCA	0.632000													24	36					0	0	0.003954	0	0
RASAL1	8437	broad.mit.edu	37	12	113554893	113554893	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:113554893G>T	ENST00000546530.1	-	9	1001	c.716C>A	c.(715-717)gCc>gAc	p.A239D	RASAL1_ENST00000261729.5_Missense_Mutation_p.A239D|RASAL1_ENST00000548055.1_Missense_Mutation_p.A239D|RASAL1_ENST00000446861.3_Missense_Mutation_p.A239D|RASAL1_ENST00000418411.2_5'UTR	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	239					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						ATCCTCCTCGGCTCTGGGAAA	0.617000													32	20					1.42033e-22	3.38695e-22	0.004289	1	0
CD226	10666	broad.mit.edu	37	18	67563239	67563239	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr18:67563239G>A	ENST00000280200.4	-	4	693	c.425C>T	c.(424-426)tCg>tTg	p.S142L	CD226_ENST00000581982.1_5'UTR|CD226_ENST00000582621.1_Missense_Mutation_p.S142L|CD226_ENST00000577287.1_5'UTR	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule	142	Ig-like C2-type 2.				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	24		Esophageal squamous(42;0.129)				TCCAGGTTCCGAAACAATGTG	0.478000													36	36					0	0	0.001951	0	0
SVEP1	79987	broad.mit.edu	37	9	113139557	113139557	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:113139557C>T	ENST00000401783.2	-	45	10834	c.10498G>A	c.(10498-10500)Gaa>Aaa	p.E3500K	SVEP1_ENST00000374469.1_Missense_Mutation_p.E3477K|SVEP1_ENST00000297826.5_Missense_Mutation_p.E1426K	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3500	EGF-like 8.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TCACGTTCTTCACAGAGGCGC	0.517000													29	50					0	0	0.001061	0	0
ATP2B2	491	broad.mit.edu	37	3	10384605	10384605	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:10384605G>A	ENST00000397077.1	-	18	3188	c.2613C>T	c.(2611-2613)atC>atT	p.I871I	ATP2B2_ENST00000383800.4_Silent_p.I871I|ATP2B2_ENST00000343816.4_Silent_p.I902I|ATP2B2_ENST00000352432.4_Silent_p.I916I|ATP2B2_ENST00000360273.2_Silent_p.I916I			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	916					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						ACGTGTCCATGATGAGGTTCA	0.647000													26	85					0	0	0.001271	0	0
ZNF135	7694	broad.mit.edu	37	19	58578848	58578848	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:58578848G>A	ENST00000506786.1	+	5	1424	c.870G>A	c.(868-870)ggG>ggA	p.G290G	ZNF135_ENST00000511556.1_Silent_p.G344G|ZNF135_ENST00000359978.6_Silent_p.G344G|ZNF135_ENST00000313434.5_Silent_p.G332G|ZNF135_ENST00000401053.4_Silent_p.G356G|ZNF135_ENST00000439855.2_Silent_p.G332G			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	344					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		GTGAGTGTGGGAAAGCCTTCC	0.552000													12	22					0	0	0.000978	0	0
COL6A1	1291	broad.mit.edu	37	21	47409526	47409526	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr21:47409526G>A	ENST00000361866.3	+	10	977	c.863G>A	c.(862-864)aGa>aAa	p.R288K		NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	288	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	TTCCAGGGAAGACCCGGGGAC	0.682000													28	66					0	0	0.001512	0	0
BIN1	274	broad.mit.edu	37	2	127809905	127809905	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:127809905C>T	ENST00000316724.5	-	15	1708	c.1297G>A	c.(1297-1299)Ggg>Agg	p.G433R	BIN1_ENST00000351659.3_Missense_Mutation_p.G346R|BIN1_ENST00000346226.3_Missense_Mutation_p.G358R|BIN1_ENST00000357970.3_Missense_Mutation_p.G390R|BIN1_ENST00000348750.4_Intron|BIN1_ENST00000376113.2_Intron|BIN1_ENST00000259238.4_Intron|BIN1_ENST00000466111.1_Intron|BIN1_ENST00000393040.3_Intron|BIN1_ENST00000393041.3_Missense_Mutation_p.G315R|BIN1_ENST00000409400.1_Intron|BIN1_ENST00000352848.3_Intron	NM_139343.2	NP_647593.1	O00499	BIN1_HUMAN	bridging integrator 1	433					cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)	24	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CTGGGCTCCCCGGAAGGCAGG	0.701000													9	13					0	0	0.000978	0	0
OR10W1	81341	broad.mit.edu	37	11	58034453	58034453	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:58034453C>T	ENST00000395079.2	-	1	1279	c.878G>A	c.(877-879)gGg>gAg	p.G293E		NM_207374.3	NP_997257.2	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W, member 1	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(1)	26		Breast(21;0.0589)				AAGAACTCTCCCTACGGCCCC	0.507000													48	34					0	0	0.003610	0	0
ENAH	55740	broad.mit.edu	37	1	225707031	225707031	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:225707031C>A	ENST00000366844.2	-	5	1122	c.671G>T	c.(670-672)cGg>cTg	p.R224L	ENAH_ENST00000284563.6_Missense_Mutation_p.R243L|ENAH_ENST00000391874.2_5'UTR|ENAH_ENST00000366843.2_Missense_Mutation_p.R224L	NM_001008493.1	NP_001008493.1	Q8N8S7	ENAH_HUMAN	enabled homolog (Drosophila)	224					axon guidance|intracellular transport|T cell receptor signaling pathway	cytosol|filopodium|focal adhesion|lamellipodium|synapse	actin binding|SH3 domain binding|WW domain binding			NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.19)		TTGCCTCTCCCGATCCAGGcg	0.597000													7	183					0.00198382	0.00467706	0.001984	1	0
TSHZ2	128553	broad.mit.edu	37	20	51872769	51872769	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:51872769C>T	ENST00000371497.5	+	2	3659	c.2772C>T	c.(2770-2772)ccC>ccT	p.P924P	TSHZ2_ENST00000603338.2_Silent_p.P921P|TSHZ2_ENST00000329613.6_Silent_p.P921P|RP4-678D15.1_ENST00000606932.1_RNA	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	924					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			AAGGCCACCCCATCTTTTATT	0.478000													18	44					0	0	0.004990	0	0
ADCY3	109	broad.mit.edu	37	2	25057470	25057470	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:25057470G>A	ENST00000260600.5	-	10	2702	c.1851C>T	c.(1849-1851)gaC>gaT	p.D617D	ADCY3_ENST00000405392.1_Silent_p.D250D	NM_004036.3	NP_004027.2	O60266	ADCY3_HUMAN	adenylate cyclase 3	617					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			NS(1)|breast(5)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(4)|skin(2)	44	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					CCATCTCGGGGTCCATGAACC	0.577000													59	59					0	0	0.003610	0	0
SIK1	150094	broad.mit.edu	37	21	44841138	44841138	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr21:44841138G>A	ENST00000270162.6	-	6	741	c.609C>T	c.(607-609)ccC>ccT	p.P203P		NM_173354.3	NP_775490.2	P57059	SIK1_HUMAN	salt-inducible kinase 1	203	Protein kinase.				anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|testis(2)|urinary_tract(1)	21						TGTCCAGCTGGGGGCCTTCAT	0.672000													22	48					0	0	0.001882	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48556297	48556297	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:48556297C>T	ENST00000354276.3	-	16	1864	c.1537G>A	c.(1537-1539)Gaa>Aaa	p.E513K	PLA2G4C_ENST00000596510.1_5'UTR|PLA2G4C_ENST00000599921.1_Missense_Mutation_p.E513K|PLA2G4C_ENST00000599111.1_Missense_Mutation_p.E523K|PLA2G4C_ENST00000413144.2_Missense_Mutation_p.E513K	NM_001159323.1	NP_001152795.1	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	513	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		TTCTTGTTTTCCCTGACATTC	0.478000													28	77					0	0	0.001061	0	0
DNAH3	55567	broad.mit.edu	37	16	20970652	20970652	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:20970652C>T	ENST00000261383.3	-	54	10674	c.10675G>A	c.(10675-10677)Ggc>Agc	p.G3559S	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3559	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GCAATAGGGCCTTGGCCTTGG	0.537000													67	72					0	0	0.003610	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55331421	55331421	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:55331421C>T	ENST00000391728.4	+	4	642	c.609C>T	c.(607-609)ccC>ccT	p.P203P	KIR3DL1_ENST00000541392.1_Silent_p.P203P|KIR3DL1_ENST00000538269.1_Silent_p.P203P|KIR3DL1_ENST00000402254.2_Silent_p.P203P|KIR3DL1_ENST00000358178.4_Silent_p.P108P|KIR3DL1_ENST00000326542.7_Silent_p.P203P	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		CTCACACCCCCTATCAGTTGT	0.517000													48	153					0	0	0.003610	0	0
UGT2B4	7363	broad.mit.edu	37	4	70355231	70355231	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:70355231C>T	ENST00000305107.6	-	3	974	c.928G>A	c.(928-930)Ggg>Agg	p.G310R	UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000381096.3_Missense_Mutation_p.G174R|UGT2B4_ENST00000512583.1_Missense_Mutation_p.G310R	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	310					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity	p.G310W(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						ACCATCGACCCCAGAGAAAAC	0.388000													24	74					0	0	0.003330	0	0
PPP2CA	5515	broad.mit.edu	37	5	133536105	133536105	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:133536105A>G	ENST00000481195.1	-	5	939	c.659T>C	c.(658-660)tTt>tCt	p.F220S		NM_002715.2	NP_002706.1			protein phosphatase 2, catalytic subunit, alpha isozyme											endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATCTTGCCCAAAGGTGTAACC	0.463000													14	11					0	0	0.002450	0	0
DNAH3	55567	broad.mit.edu	37	16	20974801	20974801	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:20974801C>T	ENST00000261383.3	-	53	10404	c.10405G>A	c.(10405-10407)Gga>Aga	p.G3469R	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3469					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TTCTCCAATCCTTGAGAGAAC	0.512000													29	28					0	0	0.001061	0	0
PID1	55022	broad.mit.edu	37	2	229890444	229890444	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:229890444G>A	ENST00000392054.3	-	4	990	c.651C>T	c.(649-651)ttC>ttT	p.F217F	PID1_ENST00000354069.6_Silent_p.F219F|PID1_ENST00000392055.3_Silent_p.F186F|PID1_ENST00000409462.1_Silent_p.F137F|PID1_ENST00000482518.2_Intron	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	219	PID.					cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		AAGTCTTCCTGAAGGCCTCCA	0.552000													57	59					0	0	0.003610	0	0
TRERF1	55809	broad.mit.edu	37	6	42237139	42237139	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:42237139C>T	ENST00000541110.1	-	5	758	c.190G>A	c.(190-192)Ggt>Agt	p.G64S	TRERF1_ENST00000354325.2_Missense_Mutation_p.G64S|TRERF1_ENST00000372922.4_Missense_Mutation_p.G64S|TRERF1_ENST00000340840.2_Missense_Mutation_p.G64S|TRERF1_ENST00000372917.4_Missense_Mutation_p.G64S			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	64					cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AAGCCCAGACCATCCCGTGTA	0.587000													39	96					0	0	0.004878	0	0
KIAA0922	23240	broad.mit.edu	37	4	154557689	154557689	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:154557689C>T	ENST00000409663.3	+	35	4843	c.4791C>T	c.(4789-4791)ttC>ttT	p.F1597F	KIAA0922_ENST00000440693.1_Silent_p.F1514F|KIAA0922_ENST00000409959.3_Silent_p.F1598F	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	1597						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				ATGCAAATTTCCCACTGTCTA	0.418000													27	60					0	0	0.001271	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18658387	18658387	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:18658387G>A	ENST00000433979.1	+	23	3308	c.3192G>A	c.(3190-3192)ggG>ggA	p.G1064G	PIK3C2G_ENST00000266497.5_Silent_p.G1064G|PIK3C2G_ENST00000538779.1_Silent_p.G1105G	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1064	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				CATTTGGAGGGATAAAAAGGT	0.368000													7	16					0	0	0.003080	0	0
C7orf26	79034	broad.mit.edu	37	7	6647684	6647684	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:6647684G>A	ENST00000344417.5	+	6	1509	c.1242G>A	c.(1240-1242)ctG>ctA	p.L414L	C7orf26_ENST00000359073.5_Silent_p.L317L|C7orf26_ENST00000472693.1_3'UTR	NM_024067.2	NP_076972.2	Q96N11	CG026_HUMAN	chromosome 7 open reading frame 26	414										endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	11		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		CGCCCCCGCTGGGCTACGGGG	0.726000													6	39					0	0	0.004482	0	0
HERC2	8924	broad.mit.edu	37	15	28369256	28369256	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:28369256G>A	ENST00000261609.7	-	85	13223	c.13115C>T	c.(13114-13116)tCg>tTg	p.S4372L		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	4372					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTCGTCGAGCGAGCCTTCCAG	0.562000													40	27					0	0	0.001706	0	0
CLASRP	11129	broad.mit.edu	37	19	45563722	45563722	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:45563722C>T	ENST00000544944.2	+	8	1478	c.786C>T	c.(784-786)taC>taT	p.Y262Y	CLASRP_ENST00000391953.4_Silent_p.Y200Y|CLASRP_ENST00000221455.3_Silent_p.Y262Y			Q8N2M8	CLASR_HUMAN	CLK4-associating serine/arginine rich protein	262					mRNA processing|RNA splicing	nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|pancreas(2)|prostate(1)	16						AGGCCATGTACTCGGTGAGGT	0.612000													166	333					0	0	0.003610	0	0
SLC12A6	9990	broad.mit.edu	37	15	34546687	34546687	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:34546687A>T	ENST00000354181.3	-	9	1472	c.980T>A	c.(979-981)gTc>gAc	p.V327D	SLC12A6_ENST00000458406.2_Missense_Mutation_p.V268D|SLC12A6_ENST00000397702.2_Missense_Mutation_p.V268D|SLC12A6_ENST00000397707.2_Missense_Mutation_p.V312D|SLC12A6_ENST00000290209.5_Missense_Mutation_p.V276D|SLC12A6_ENST00000451844.2_Missense_Mutation_p.V139D|SLC12A6_ENST00000560611.1_Missense_Mutation_p.V327D|SLC12A6_ENST00000560164.1_Missense_Mutation_p.V139D|SLC12A6_ENST00000558589.1_Missense_Mutation_p.V318D|SLC12A6_ENST00000558667.1_Missense_Mutation_p.V327D			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	327					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	TACCATAAGGACCAAGAAAGC	0.473000													24	20					0	0	0.002299	0	0
FER1L6	654463	broad.mit.edu	37	8	125072424	125072424	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:125072424C>T	ENST00000522917.1	+	23	3084	c.2878C>T	c.(2878-2880)Cct>Tct	p.P960S	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.P960S|FER1L6-AS2_ENST00000601180.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	960						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GCGGTAGGTTCCTCCTTCTGG	0.547000													137	80					0	0	0.003610	0	0
POLR3A	11128	broad.mit.edu	37	10	79762037	79762037	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:79762037G>A	ENST00000372371.3	-	17	2414	c.2277C>T	c.(2275-2277)atC>atT	p.I759I		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	759					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			CGTGGTCACGGATCACAGACA	0.552000													7	1					0	0	0.001984	0	0
UBXN10	127733	broad.mit.edu	37	1	20517436	20517436	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:20517436G>A	ENST00000375099.3	+	2	466	c.382G>A	c.(382-384)Gag>Aag	p.E128K		NM_152376.3	NP_689589.1	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	128										endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|skin(2)	14						CCTGGAGGAGGAGGCTGTGGA	0.522000													30	41					0	0	0.001512	0	0
SCD	6319	broad.mit.edu	37	10	102107992	102107992	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:102107992C>T	ENST00000370355.2	+	2	580	c.199C>T	c.(199-201)Ccc>Tcc	p.P67S		NM_005063.4	NP_005054.3	O00767	ACOD_HUMAN	stearoyl-CoA desaturase (delta-9-desaturase)	67					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			endometrium(1)|large_intestine(3)|lung(5)	9		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		AGGCCCAAGCCCCAAGGTTGA	0.458000													61	115					0	0	0.003610	0	0
MUC21	394263	broad.mit.edu	37	6	30955901	30955901	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:30955901C>T	ENST00000376296.3	+	3	1872	c.1631C>T	c.(1630-1632)cCt>cTt	p.P544L	MUC21_ENST00000486149.2_Missense_Mutation_p.P90L	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	544	Cytoplasmic tail.					integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						AGGTGGAGTCCTAACTGGTTC	0.602000													27	51					0	0	0.001786	0	0
LST3	0	broad.mit.edu	37	12	21174514	21174514	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:21174514G>A	ENST00000381541.3	+	4	544	c.479G>A	c.(478-480)aGa>aAa	p.R160K	LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000554957.1_Missense_Mutation_p.R160K|SLCO1B3_ENST00000553473.1_Intron|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.R113K																							ATAATAGAAAGAGGTAAGAAT	0.249000													3	7					0	0	0.000602	0	0
DYNAP	284254	broad.mit.edu	37	18	52262285	52262285	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr18:52262285G>A	ENST00000321600.1	+	2	297	c.251G>A	c.(250-252)gGa>gAa	p.G84E	DYNAP_ENST00000585973.1_Intron	NM_173629.1	NP_775900.1			dynactin associated protein																		GTGAACCCAGGAATCCTTGCA	0.448000													37	101					0	0	0.002222	0	0
LY9	4063	broad.mit.edu	37	1	160769848	160769848	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:160769848G>A	ENST00000263285.5	+	2	460	c.430G>A	c.(430-432)Gag>Aag	p.E144K	LY9_ENST00000471816.1_3'UTR|LY9_ENST00000368041.2_Missense_Mutation_p.E104K|LY9_ENST00000368040.1_5'UTR|LY9_ENST00000368039.2_Missense_Mutation_p.E144K|LY9_ENST00000341032.4_Missense_Mutation_p.E144K	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	144	Ig-like V-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CACCACTGAGGAGGAATTCAC	0.408000													49	132					0	0	0.003610	0	0
SERPINB11	89778	broad.mit.edu	37	18	61387373	61387373	+	RNA	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr18:61387373C>T	ENST00000544088.1	+	0	664				SERPINB11_ENST00000536691.1_RNA|SERPINB11_ENST00000538847.1_RNA|SERPINB11_ENST00000382749.5_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				GTTAAAAGTCCTTTTCAGCTA	0.328000													16	22					0	0	0.004990	0	0
KDM5B	10765	broad.mit.edu	37	1	202731857	202731857	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:202731857G>A	ENST00000367265.3	-	7	2052	c.888C>T	c.(886-888)ccC>ccT	p.P296P	KDM5B_ENST00000367264.2_Silent_p.P332P	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	296					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						ATCGACTCTTGGGCTTTTCCT	0.388000													42	208					0	0	0.003214	0	0
CA6	765	broad.mit.edu	37	1	9011504	9011504	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:9011504C>T	ENST00000319474.2	+	3	306	c.282C>T	c.(280-282)ctC>ctT	p.L94L	CA6_ENST00000377443.2_Intron|CA6_ENST00000377442.2_Intron|CA6_ENST00000476083.1_Intron|CA6_ENST00000377436.3_Intron			P23280	CAH6_HUMAN	carbonic anhydrase VI	91					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(5)	16	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		AACTCTTCCTCCCCTCCTTGT	0.498000													5	23					0	0	0.001984	0	0
MAP4K4	9448	broad.mit.edu	37	2	102490688	102490688	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:102490688C>T	ENST00000413150.2	+	22	2580	c.2525C>T	c.(2524-2526)tCt>tTt	p.S842F	MAP4K4_ENST00000347699.4_Missense_Mutation_p.S927F|MAP4K4_ENST00000302217.5_Missense_Mutation_p.S730F|MAP4K4_ENST00000350878.4_Missense_Mutation_p.S967F|MAP4K4_ENST00000324219.4_Missense_Mutation_p.S1008F|MAP4K4_ENST00000456652.1_Missense_Mutation_p.S726F|MAP4K4_ENST00000350198.4_Missense_Mutation_p.S846F|MAP4K4_ENST00000425019.1_Missense_Mutation_p.S960F	NM_001242560.1|NM_004834.4	NP_001229489.1|NP_004825.3	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	927					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						AGGTTTAACTCTGAGATTCTG	0.478000													10	12					0	0	0.000673	0	0
PDE1C	5137	broad.mit.edu	37	7	31864516	31864516	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr7:31864516G>A	ENST00000396184.3	-	14	1575	c.1371C>T	c.(1369-1371)acC>acT	p.T457T	PDE1C_ENST00000321453.7_Silent_p.T457T|PDE1C_ENST00000396193.1_Silent_p.T517T|PDE1C_ENST00000396182.2_Silent_p.T457T|PDE1C_ENST00000396191.1_Silent_p.T457T	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	457	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			CAGTTTGAGAGGTTTCATCGA	0.493000													93	86					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179615439	179615439	+	Silent	SNP	A	A	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:179615439A>T	ENST00000360870.5	-	46	11910	c.11688T>A	c.(11686-11688)gcT>gcA	p.A3896A	TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9720							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTTTCACTAGCTATTTCTT	0.348000													8	14					0	0	0.003080	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414844	14414844	+	RNA	SNP	T	T	C	rs148060711	by1000genomes	TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr21:14414844T>C	ENST00000507941.1	+	0	95																											ACTGGGCCTGTGCCAATGGCC	0.433000													4	59					0	0	0.001984	0	0
ACSM2B	348158	broad.mit.edu	37	16	20566663	20566663	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:20566663G>A	ENST00000329697.6	-	4	692	c.524C>T	c.(523-525)cCt>cTt	p.P175L	ACSM2B_ENST00000565232.1_Missense_Mutation_p.P175L|ACSM2B_ENST00000567001.1_Missense_Mutation_p.P175L|ACSM2B_ENST00000565322.1_Missense_Mutation_p.P96L|ACSM2B_ENST00000414188.2_Missense_Mutation_p.P175L	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	175					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TCTCAGAGAAGGACATTCAGA	0.453000													67	99					0	0	0.003610	0	0
OGDHL	55753	broad.mit.edu	37	10	50948822	50948822	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr10:50948822G>A	ENST00000374103.4	-	16	2159	c.2074C>T	c.(2074-2076)Cat>Tat	p.H692Y	OGDHL_ENST00000419399.1_Missense_Mutation_p.H635Y|OGDHL_ENST00000432695.1_Missense_Mutation_p.H483Y	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	692					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						GGCCAGAGATGATTCATAGGC	0.637000													25	15					0	0	0.004656	0	0
CHSY3	337876	broad.mit.edu	37	5	129520634	129520634	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:129520634C>T	ENST00000305031.4	+	3	2157	c.1799C>T	c.(1798-1800)tCt>tTt	p.S600F		NM_175856.4	NP_787052.3	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	600						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		ATATCTAATTCTTTAAAGATA	0.383000													13	3					0	0	0.001368	0	0
IGDCC4	57722	broad.mit.edu	37	15	65688237	65688237	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:65688237G>A	ENST00000352385.2	-	7	1471	c.1262C>T	c.(1261-1263)gCc>gTc	p.A421V		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	421	Ig-like C2-type 4.					integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						CACCACCACGGCCAGCGACGC	0.706000													15	6					0	0	0.003163	0	0
GREB1	9687	broad.mit.edu	37	2	11758601	11758601	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr2:11758601C>T	ENST00000381486.2	+	22	3900	c.3600C>T	c.(3598-3600)ccC>ccT	p.P1200P	GREB1_ENST00000396123.1_Silent_p.P198P|GREB1_ENST00000234142.5_Silent_p.P1200P	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1200	Ser-rich.					integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CGCCCCAGCCCGACTGTAGCC	0.692000													5	13					0	0	0.000602	0	0
WDR72	256764	broad.mit.edu	37	15	53908292	53908292	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:53908292G>A	ENST00000396328.1	-	15	2350	c.2111C>T	c.(2110-2112)tCc>tTc	p.S704F	WDR72_ENST00000557913.1_Missense_Mutation_p.S701F|WDR72_ENST00000559418.1_Missense_Mutation_p.S714F|WDR72_ENST00000360509.5_Missense_Mutation_p.S704F	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	704										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		GAATGAACTGGAAGAGTCAAC	0.423000													25	9					0	0	0.003954	0	0
PTHLH	5744	broad.mit.edu	37	12	28116382	28116382	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:28116382C>T	ENST00000535992.1	-	3	769	c.423G>A	c.(421-423)cgG>cgA	p.R141R	PTHLH_ENST00000354417.3_Silent_p.R141R|PTHLH_ENST00000545234.1_Silent_p.R141R|PTHLH_ENST00000395868.3_Silent_p.R141R|PTHLH_ENST00000538310.1_Silent_p.R141R|PTHLH_ENST00000395872.1_Silent_p.R141R|RP11-993B23.3_ENST00000538113.1_RNA|PTHLH_ENST00000201015.4_Silent_p.R141R|PTHLH_ENST00000539239.1_Silent_p.R141R			P12272	PTHR_HUMAN	parathyroid hormone-like hormone	141					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|stomach(1)	10	Lung SC(9;0.184)					AGCGAGTTCGCCGTTTTTTCT	0.547000													27	61					0	0	0.001061	0	0
ABO	28	broad.mit.edu	37	9	136131068	136131068	+	RNA	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:136131068C>T	ENST00000453660.2	-	0	1060							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		GGTTCCGGACCGCCTGGTGGT	0.667000													8	7					0	0	0.004482	0	0
UGT3A2	167127	broad.mit.edu	37	5	36035919	36035919	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:36035919G>A	ENST00000282507.3	-	7	1554	c.1453C>T	c.(1453-1455)Ctg>Ttg	p.L485L	UGT3A2_ENST00000545528.1_Silent_p.L183L|UGT3A2_ENST00000513300.1_Silent_p.L451L	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	485						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACGTCGAGCAGGTACTGCTCA	0.617000													40	14					0	0	0.001951	0	0
DNAH17	8632	broad.mit.edu	37	17	76446802	76446802	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr17:76446802C>T	ENST00000389840.5	-	67	10943	c.10819G>A	c.(10819-10821)Gag>Aag	p.E3607K	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.E3616K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TTGGTGGTCTCCAGATTCTCC	0.607000													27	20					0	0	0.003954	0	0
TJP2	9414	broad.mit.edu	37	9	71866098	71866098	+	Missense_Mutation	SNP	C	C	T	rs148629740	by1000genomes	TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:71866098C>T	ENST00000377245.4	+	21	3347	c.3139C>T	c.(3139-3141)Cgg>Tgg	p.R1047W	TJP2_ENST00000453658.2_Intron|TJP2_ENST00000348208.4_Intron|TJP2_ENST00000539225.1_Missense_Mutation_p.R1078W|TJP2_ENST00000535702.1_Missense_Mutation_p.R1014W	NM_004817.3	NP_004808.2	Q9UDY2	ZO2_HUMAN	tight junction protein 2	1047					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(5)|lung(9)|prostate(3)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	35						TACCTTTGGGCGGTCTATACT	0.522000													33	85					0	0	0.004289	0	0
KCNT2	343450	broad.mit.edu	37	1	196274467	196274467	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:196274467G>A	ENST00000367433.5	-	21	2521	c.2420C>T	c.(2419-2421)tCc>tTc	p.S807F	KCNT2_ENST00000451324.2_Intron|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000294725.8_Missense_Mutation_p.S831F|KCNT2_ENST00000367431.4_Missense_Mutation_p.S757F			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	831						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						ACTGAGACTGGAAAACAACCT	0.363000													18	22					0	0	0.006122	0	0
HOMER2	9455	broad.mit.edu	37	15	83527871	83527871	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr15:83527871C>T	ENST00000304231.8	-	5	629	c.437G>A	c.(436-438)gGg>gAg	p.G146E	HOMER2_ENST00000399166.2_Missense_Mutation_p.G135E|HOMER2_ENST00000426485.1_Missense_Mutation_p.G146E|HOMER2_ENST00000450735.2_Missense_Mutation_p.G135E	NM_199330.2	NP_955362.1	Q9NSB8	HOME2_HUMAN	homer homolog 2 (Drosophila)	146					metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				cervix(1)|endometrium(2)|lung(6)	9						ATCGTCCGTCCCGTTGACACT	0.517000													151	53					0	0	0.003610	0	0
SNHG12	85028	broad.mit.edu	37	1	28905160	28905160	+	RNA	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:28905160G>A	ENST00000488745.1	-	0	1257				SNHG12_ENST00000483436.1_RNA|SNHG12_ENST00000475441.1_RNA|SNHG12_ENST00000531126.1_RNA																							AAATGACCGGGGTCCTTGCCT	0.413000													22	45					0	0	0.001523	0	0
NCR1	9437	broad.mit.edu	37	19	55420724	55420724	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:55420724G>A	ENST00000594765.1	+	4	501	c.476G>A	c.(475-477)gGa>gAa	p.G159E	NCR1_ENST00000357397.5_Missense_Mutation_p.G52E|NCR1_ENST00000338835.5_Missense_Mutation_p.G159E|NCR1_ENST00000350790.5_Missense_Mutation_p.G64E|NCR1_ENST00000598576.1_Missense_Mutation_p.G147E|NCR1_ENST00000447255.1_Missense_Mutation_p.G159E|NCR1_ENST00000291890.4_Missense_Mutation_p.G159E			O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	159	Ig-like 2.				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(193;0.0449)		CTCAAGGAGGGAAGATCCAGC	0.582000													38	46					0	0	0.001485	0	0
RBFOX1	54715	broad.mit.edu	37	16	7629881	7629881	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:7629881C>T	ENST00000340209.4	+	3	685	c.388C>T	c.(388-390)Ccc>Tcc	p.P130S	RBFOX1_ENST00000311745.5_Missense_Mutation_p.P145S|RBFOX1_ENST00000436368.2_Missense_Mutation_p.P145S|RBFOX1_ENST00000550418.1_Missense_Mutation_p.P125S|RBFOX1_ENST00000535565.2_Intron|RBFOX1_ENST00000422070.4_Missense_Mutation_p.P168S|RBFOX1_ENST00000552089.1_Missense_Mutation_p.P160S|RBFOX1_ENST00000553186.1_Missense_Mutation_p.P125S|RBFOX1_ENST00000355637.4_Missense_Mutation_p.P145S|RBFOX1_ENST00000547338.1_Missense_Mutation_p.P125S|RBFOX1_ENST00000547372.1_Missense_Mutation_p.P168S			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	125	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						CTCCAATATCCCCTTCAGGTT	0.557000													23	43					0	0	0.001882	0	0
SEZ6L	23544	broad.mit.edu	37	22	26736577	26736577	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:26736577G>A	ENST00000529632.2	+	10	2387	c.2191G>A	c.(2191-2193)Gga>Aga	p.G731R	SEZ6L_ENST00000248933.6_Missense_Mutation_p.G731R|SEZ6L_ENST00000403121.1_Missense_Mutation_p.G504R|SEZ6L_ENST00000360929.3_Missense_Mutation_p.G731R|SEZ6L_ENST00000343706.4_Missense_Mutation_p.G731R|SEZ6L_ENST00000404234.3_Missense_Mutation_p.G731R|SEZ6L_ENST00000402979.1_Missense_Mutation_p.G504R	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	731	CUB 3.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						AAAGGGCCAGGGATTTATCAT	0.463000													19	60					0	0	0.001882	0	0
CNOT1	23019	broad.mit.edu	37	16	58622709	58622709	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:58622709G>A	ENST00000317147.5	-	3	536	c.204C>T	c.(202-204)ttC>ttT	p.F68F	CNOT1_ENST00000569240.1_Silent_p.F68F|CNOT1_ENST00000441024.2_Silent_p.F68F	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	68					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		ATACCTGATGGAAATCTTTGC	0.423000													8	6					0	0	0.000443	0	0
HRASLS	57110	broad.mit.edu	37	3	192973467	192973467	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:192973467A>T	ENST00000264735.2	+	2	437	c.343A>T	c.(343-345)Aac>Tac	p.N115Y	HRASLS_ENST00000602513.1_Missense_Mutation_p.N10Y	NM_020386.4	NP_065119.2	Q9HDD0	HRSL1_HUMAN	HRAS-like suppressor	10										breast(1)|large_intestine(2)|lung(4)|prostate(1)|skin(2)	10	all_cancers(143;9.1e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000159)		CTTCAGTTTGAACTACCCTGG	0.443000													7	96					0	0	0.001984	0	0
PITPNM2	57605	broad.mit.edu	37	12	123519098	123519098	+	Missense_Mutation	SNP	C	C	T	rs140068156		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr12:123519098C>T	ENST00000280562.5	-	2	245	c.40G>A	c.(40-42)Gtg>Atg	p.V14M	PITPNM2_ENST00000542749.1_Missense_Mutation_p.V14M|PITPNM2_ENST00000546049.1_Missense_Mutation_p.V14M|PITPNM2_ENST00000392428.1_Missense_Mutation_p.V14M|PITPNM2_ENST00000320201.4_Missense_Mutation_p.V14M|PITPNM2_ENST00000451868.2_5'UTR			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	14					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TACTCCTCCACGGTCATTGGC	0.572000													19	51					0	0	0.001216	0	0
DYNC1LI1	51143	broad.mit.edu	37	3	32570044	32570044	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr3:32570044C>T	ENST00000273130.4	-	12	1459	c.1356G>A	c.(1354-1356)ttG>ttA	p.L452L	DYNC1LI1_ENST00000432458.2_Silent_p.L336L	NM_016141.3	NP_057225.2	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain 1	452					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity			kidney(2)|large_intestine(1)|lung(3)|ovary(1)	7						TCTTTTTACTCAACAAACTGT	0.448000													15	41					0	0	0.003163	0	0
ZNF366	167465	broad.mit.edu	37	5	71740006	71740006	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:71740006G>A	ENST00000318442.5	-	5	2302	c.1812C>T	c.(1810-1812)ttC>ttT	p.F604F		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	604					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		CGTCTGACTGGAACACCGGCA	0.657000													97	45					0	0	0.003610	0	0
SEC16A	9919	broad.mit.edu	37	9	139345792	139345792	+	Silent	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:139345792C>T	ENST00000313050.7	-	21	6301	c.6228G>A	c.(6226-6228)acG>acA	p.T2076T	SEC16A_ENST00000290037.6_Silent_p.T1898T|SEC16A_ENST00000431893.2_Silent_p.T1898T|SEC16A_ENST00000371706.3_Silent_p.T1898T	NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	1898	Pro-rich.|Required for interaction with SEC23A.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GAGGTGGCTGCGTGGGACCCG	0.617000													12	18					0	0	0.000978	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628247	173628247	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr1:173628247T>C	ENST00000333279.2	-	2	371	c.311A>G	c.(310-312)aAt>aGt	p.N104S		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	120										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						GGTTTTTTCATTCAGATTCAC	0.353000													22	106					0	0	0.001882	0	0
ZNF217	7764	broad.mit.edu	37	20	52198478	52198478	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr20:52198478G>A	ENST00000371471.2	-	2	1313	c.888C>T	c.(886-888)ttC>ttT	p.F296F	ZNF217_ENST00000302342.3_Silent_p.F296F			O75362	ZN217_HUMAN	zinc finger protein 217	296					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			GCCAAGCCTGGAAGGTGGTGA	0.527000													59	120					0	0	0.003610	0	0
DNAH5	1767	broad.mit.edu	37	5	13911564	13911564	+	Silent	SNP	G	G	A			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:13911564G>A	ENST00000265104.4	-	12	1679	c.1575C>T	c.(1573-1575)ttC>ttT	p.F525F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	525	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GCTGGTCTAGGAAATTGTATT	0.308000									Kartagener syndrome				42	23					0	0	0.003610	0	0
RP1L1	94137	broad.mit.edu	37	8	10469740	10469740	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr8:10469740C>T	ENST00000382483.3	-	4	2091	c.1868G>A	c.(1867-1869)gGa>gAa	p.G623E		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	623					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GGAAGAGGCTCCTTCCGAGTC	0.647000													87	23					0	0	0.003610	0	0
DHX15	1665	broad.mit.edu	37	4	24556366	24556368	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr4:24556366_24556368delAAG	ENST00000336812.4	-	5	1216_1218	c.1060_1062delCTT	c.(1060-1062)del	p.L354del		NM_001358.2	NP_001349.2	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 15	354	Helicase C-terminal.				mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	30		Breast(46;0.0503)				CAGTTAAGAAAAGAAGAAGATCT	0.340													30	108	---	---	---	---					
MAST4	375449	broad.mit.edu	37	5	65892767	65892768	+	In_Frame_Ins	INS	-	-	GCC			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr5:65892767_65892768insGCC	ENST00000404260.3	+	1	592_593	c.284_285insGCC	c.(283-285)ccc>cGCCcc	p.94_95insR	MAST4_ENST00000403625.2_In_Frame_Ins_p.94_95insR|MAST4_ENST00000406374.1_In_Frame_Ins_p.94_95insR|MAST4_ENST00000406039.1_In_Frame_Ins_p.94_95insR			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	94						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GTCCTTGCGCTGCCGCCGCCGC	0.792													6	1	---	---	---	---					
VARS	7407	broad.mit.edu	37	6	31762891	31762915	+	Frame_Shift_Del	DEL	CCTCCCCATCCGGGACCCTCCCCAG	CCTCCCCATCCGGGACCCTCCCCAG	-			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:31762891_31762915delCCTCCCCATCCGGGACCCTCCCCAG	ENST00000375663.3	-	2	520_544	c.80_104delCTGGGGAGGGTCCCGGATGGGGAGG	c.(79-105)gafs	p.AGEGPGWGG27fs	VARS_ENST00000444930.2_Intron	NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	27					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	GGGGTGGGCTCCTCCCCATCCGGGACCCTCCCCAGCCTCCCCATA	0.684													33	274	---	---	---	---					
C6orf223	221416	broad.mit.edu	37	6	43970503	43970504	+	In_Frame_Ins	INS	-	-	GCG	rs72369323		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr6:43970503_43970504insGCG	ENST00000336600.5	+	4	389_390	c.369_370insGCG	c.(367-372)cgcggc>cgGCGcggc	p.123_124insR	C6orf223_ENST00000439969.2_3'UTR|RP5-1120P11.1_ENST00000607590.1_RNA|C6orf223_ENST00000448947.2_3'UTR|RP5-1120P11.1_ENST00000422059.1_RNA	NM_001171992.1|NM_153246.4	NP_001165463.1|NP_694978.2	Q8N319	CF223_HUMAN	chromosome 6 open reading frame 223	123										central_nervous_system(1)|lung(2)|pancreas(1)|prostate(1)|urinary_tract(1)	6	all_cancers(18;2.28e-07)|all_epithelial(2;1.62e-08)|Lung NSC(15;0.000172)|all_lung(25;0.000533)|Hepatocellular(11;0.00309)|Ovarian(13;0.0437)		all cancers(41;0.00141)|Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.217)			CGGTAGAGCGCgcggcggcggc	0.777													7	18	---	---	---	---					
LINC00475	158314	broad.mit.edu	37	9	94904432	94904432	+	RNA	DEL	G	G	-	rs58003635		TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:94904432delG	ENST00000416438.2	+	0	184					NR_027341.1																						GGCCTTCTTTGGGGGGGGGGT	0.612													3	4	---	---	---	---					
GOLGA2	2801	broad.mit.edu	37	9	131022359	131022379	+	In_Frame_Del	DEL	TCCTTCAGCTCGCTCAGCTTC	TCCTTCAGCTCGCTCAGCTTC	-			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr9:131022359_131022379delTCCTTCAGCTCGCTCAGCTTC	ENST00000421699.2	-	18	1779_1799	c.1767_1787delGAAGCTGAGCGAGCTGAAGGA	c.(1765-1788)gaa>ga	p.EKLSELKE589del		NM_004486.4	NP_004477.3	Q08379	GOGA2_HUMAN	golgin A2	589						Golgi cisterna membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34						GGTTACCGTTTCCTTCAGCTCGCTCAGCTTCTCCTGCAGCT	0.629													33	99	---	---	---	---					
FOLH1	2346	broad.mit.edu	37	11	49168447	49168447	+	Frame_Shift_Del	DEL	A	A	-			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:49168447delA	ENST00000340334.7	-	20	2437	c.2069delT	c.(2068-2070)tcfs	p.F690fs	FOLH1_ENST00000356696.3_Frame_Shift_Del_p.F674fs|FOLH1_ENST00000343844.4_Frame_Shift_Del_p.F397fs|FOLH1_ENST00000256999.2_Frame_Shift_Del_p.F705fs|FOLH1_ENST00000533034.1_Frame_Shift_Del_p.F659fs	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	705					proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	AATTCCTGGGAATGACTCCCC	0.433													42	27	---	---	---	---					
TMEM225	338661	broad.mit.edu	37	11	123753892	123753892	+	Frame_Shift_Del	DEL	A	A	-			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr11:123753892delA	ENST00000375026.2	-	4	847	c.631delT	c.(631-633)ccfs	p.S211fs		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	211						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						TTGTTTAGGGAATTCACAGTG	0.398													43	35	---	---	---	---					
SEC14L5	9717	broad.mit.edu	37	16	5055987	5055987	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr16:5055987delG	ENST00000251170.7	+	12	1555	c.1375delG	c.(1375-1377)gafs	p.G460fs		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	460	CRAL-TRIO.					integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						CCAGGGACCCGGAGGCCTTGT	0.537													12	23	---	---	---	---					
OR7E24	26648	broad.mit.edu	37	19	9361741	9361741	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:9361741delT	ENST00000456448.1	+	1	136	c.22delT	c.(22-24)ttfs	p.F11fs		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	11					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						TCCAATTCTCTTTTTTTTTTT	0.388													4	5	---	---	---	---					
ICAM1	3383	broad.mit.edu	37	19	10395189	10395214	+	Frame_Shift_Del	DEL	CCAGCCCAGCCACTGGGCCCGAGGGC	CCAGCCCAGCCACTGGGCCCGAGGGC	-	rs1801714	byFrequency	TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr19:10395189_10395214delCCAGCCCAGCCACTGGGCCCGAGGGC	ENST00000264832.3	+	5	1361_1386	c.1036_1061delCCAGCCCAGCCACTGGGCCCGAGGGC	c.(1036-1062)cfs	p.PAQPLGPRA346fs	ICAM1_ENST00000423829.2_Frame_Shift_Del_p.PAQPLGPRA124fs|CTD-2369P2.5_ENST00000592893.1_RNA	NM_000201.2	NP_000192.2	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1	346	Ig-like C2-type 4.				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	GAATGGGGTTCCAGCCCAGCCACTGGGCCCGAGGGCCCAGCTCCTG	0.628													12	108	---	---	---	---					
TRIOBP	11078	broad.mit.edu	37	22	38120029	38120031	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-GN-A267-06A-21D-A196-08	TCGA-GN-A267-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89875e3e-979f-415f-8b5a-6eb72c2efda2	a2223f1c-ac5f-4f20-9d06-89cd36f262ee	g.chr22:38120029_38120031delCCT	ENST00000406386.3	+	7	1721_1723	c.1466_1468delCCT	c.(1465-1470)gcc>g	p.AS489del	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	489					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AATCCCAGAGCCTCCTCTCCCAG	0.601													7	139	---	---	---	---