Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SMARCA1	6594	broad.mit.edu	37	X	128624133	128624133	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:128624133G>T	ENST00000371122.4	-	15	1981	c.1852C>A	c.(1852-1854)Cgt>Agt	p.R618S	SMARCA1_ENST00000371121.3_Missense_Mutation_p.R606S|SMARCA1_ENST00000371123.1_Missense_Mutation_p.R606S	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	618	Helicase C-terminal.				ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding	p.R618C(1)		biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						CGGAATACACGTACTGGTTTC	0.368000													5	97					0.0215528	0.0216582	1	1	0
OR10G3	26533	broad.mit.edu	37	14	22037966	22037966	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr14:22037966G>A	ENST00000303532.1	-	1	909	c.910C>T	c.(910-912)Ctc>Ttc	p.L304F		NM_001005465.1	NP_001005465.1	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G, member 3	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)	15	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		GGGCTTCTGAGCATTCTTTTC	0.498000													26	37					0	0	1	0	0
ZNF468	90333	broad.mit.edu	37	19	53344019	53344019	+	Missense_Mutation	SNP	G	G	A	rs142875090	byFrequency	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:53344019G>A	ENST00000595646.1	-	4	1648	c.1528C>T	c.(1528-1530)Ctt>Ttt	p.L510F	ZNF468_ENST00000396409.4_Missense_Mutation_p.L457F|ZNF468_ENST00000390651.4_Missense_Mutation_p.L457F|ZNF468_ENST00000243639.4_3'UTR|ZNF28_ENST00000594602.1_Intron			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	510					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		TGGTATACAAGGGATGACATC	0.433000													110	143					0	0	1	0	0
SLC24A1	9187	broad.mit.edu	37	15	65918056	65918056	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr15:65918056C>T	ENST00000261892.6	+	2	1925	c.1638C>T	c.(1636-1638)ttC>ttT	p.F546F	SLC24A1_ENST00000544319.2_Silent_p.F546F|SLC24A1_ENST00000537259.1_Silent_p.F546F|SLC24A1_ENST00000546330.1_Silent_p.F546F|SLC24A1_ENST00000399033.4_Silent_p.F546F|SLC24A1_ENST00000339868.6_Silent_p.F546F	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	546					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						GTTCCCTCTTCTCCCGAGAGA	0.502000													88	91					0	0	1	0	0
RBM41	55285	broad.mit.edu	37	X	106331704	106331704	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:106331704G>A	ENST00000372487.1	-	5	915	c.889C>T	c.(889-891)Cct>Tct	p.P297S	RBM41_ENST00000372479.3_Missense_Mutation_p.P297S|RBM41_ENST00000203616.8_Intron	NM_001171080.1	NP_001164551.1	Q96IZ5	RBM41_HUMAN	RNA binding motif protein 41	297							nucleotide binding|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	13						GAAAACATAGGAATTTTTCGG	0.408000													117	129					0	0	1	0	0
CUL9	23113	broad.mit.edu	37	6	43163916	43163916	+	Missense_Mutation	SNP	C	C	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:43163916C>G	ENST00000252050.4	+	10	2582	c.2498C>G	c.(2497-2499)gCc>gGc	p.A833G	CUL9_ENST00000354495.3_Missense_Mutation_p.A723G|CUL9_ENST00000372647.2_Missense_Mutation_p.A833G	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	833					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						GAGATCTTCGCCAGCATCGAC	0.567000													63	81					0	0	1	0	0
WEE2	494551	broad.mit.edu	37	7	141408663	141408663	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:141408663G>A	ENST00000397541.2	+	1	511	c.105G>A	c.(103-105)gaG>gaA	p.E35E	WEE2-AS1_ENST00000488785.1_RNA	NM_001105558.1	NP_001099028.1	P0C1S8	WEE2_HUMAN	WEE1 homolog 2 (S. pombe)	35					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31	Melanoma(164;0.0171)					AAAGCAGGGAGGCTTCGAGCC	0.463000													108	237					0	0	1	0	0
BAG6	7917	broad.mit.edu	37	6	31614291	31614291	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:31614291G>A	ENST00000404765.2	-	8	1087	c.798C>T	c.(796-798)tcC>tcT	p.S266S	BAG6_ENST00000439687.2_Silent_p.S266S|BAG6_ENST00000375964.6_Silent_p.S272S|BAG6_ENST00000211379.5_Silent_p.S266S|BAG6_ENST00000375976.4_Silent_p.S266S|BAG6_ENST00000362049.6_Silent_p.S266S			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	272	4 X 29 AA approximate repeats.|Pro-rich.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						ACTCCGCAGGGGAAGGATGGC	0.597000													46	94					0	0	1	0	0
PIGM	93183	broad.mit.edu	37	1	160000284	160000284	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:160000284G>A	ENST00000368090.2	-	1	1499	c.1246C>T	c.(1246-1248)Ctg>Ttg	p.L416L		NM_145167.2	NP_660150.1	Q9H3S5	PIGM_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class M	416					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane				kidney(1)|large_intestine(4)|lung(9)|ovary(2)|skin(1)	17	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTCTCTGTCAGGGGTTCTTCT	0.378000													145	116					0	0	1	0	0
WASH6P	653440	broad.mit.edu	37	X	155252855	155252855	+	RNA	SNP	A	A	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:155252855A>C	ENST00000285718.7	+	0	806				WASH6P_ENST00000461007.1_RNA																							TTCCACACTGAGGTAGCCGAG	0.647000													5	10					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52650225	52650225	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr13:52650225T>A	ENST00000355568.4	-	19	1841	c.1702A>T	c.(1702-1704)Aat>Tat	p.N568Y		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	568							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		TGTTCTGGATTTTTACTTTCC	0.353000													26	16					0	0	1	0	0
UGT1A7	54577	broad.mit.edu	37	2	234591368	234591368	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:234591368C>T	ENST00000373426.3	+	1	785	c.785C>T	c.(784-786)cCc>cTc	p.P262L	UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron	NM_019077.2	NP_061950.2														NS(1)|endometrium(6)|kidney(5)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|prostate(1)|skin(1)	33		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TTGGAGTATCCCAAACCCGTG	0.438000													124	229					0	0	1	0	0
CCDC155	147872	broad.mit.edu	37	19	49910142	49910142	+	Splice_Site	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:49910142G>A	ENST00000447857.3	+	10	1003		c.e10-1			NM_144688.4	NP_653289.3	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155							integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						CCTTCTTCTAGAACGGGAAGC	0.473000													13	12					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54922110	54922110	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:54922110C>T	ENST00000293373.6	+	22	2534	c.2455C>T	c.(2455-2457)Ccc>Tcc	p.P819S	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.P769S	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	819					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CGTCAGCCTGCCCAGAGAAGG	0.557000													86	135					0	0	1	0	0
CRHR2	1395	broad.mit.edu	37	7	30702391	30702391	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:30702391C>T	ENST00000471646.1	-	6	1033	c.616G>A	c.(616-618)Ggc>Agc	p.G206S	CRHR2_ENST00000506074.2_Missense_Mutation_p.G206S|CRHR2_ENST00000341843.4_Missense_Mutation_p.G192S|CRHR2_ENST00000348438.4_Missense_Mutation_p.G233S	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	206					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						AGGTAGCAGCCTTCCACAAAC	0.577000													39	68					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40400729	40400729	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:40400729C>T	ENST00000338305.6	-	2	666	c.124G>A	c.(124-126)Ggg>Agg	p.G42R		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	42	LRRNT.					cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					AAGAGCAGCCCCTTGGAGGGG	0.602000													46	60					0	0	1	0	0
ZNF628	89887	broad.mit.edu	37	19	55992601	55992601	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:55992601C>T	ENST00000391718.2	+	3	594	c.29C>T	c.(28-30)cCg>cTg	p.P10L	ZNF628_ENST00000598519.1_Missense_Mutation_p.P14L			Q5EBL2	ZN628_HUMAN	zinc finger protein 628	10						nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|lung(2)	7	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		GACATGGCGCCGGCCTCTACT	0.687000													7	11					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983881	97983881	+	Silent	SNP	A	A	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:97983881A>G	ENST00000383696.2	+	1	794	c.753A>G	c.(751-753)cgA>cgG	p.R251R	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						AAGGGATACGAAAAGCTGTCT	0.403000													23	58					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247769211	247769211	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:247769211C>T	ENST00000320002.2	+	1	356	c.324C>T	c.(322-324)ggC>ggT	p.G108G	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGGCACTGGGCTCCACTGAAT	0.498000													257	166					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104319679	104319679	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr9:104319679T>C	ENST00000389120.3	+	16	2273	c.2183T>C	c.(2182-2184)cTc>cCc	p.L728P		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	728					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		GAAGAAGCACTCCTCTCTGAA	0.418000													47	5					0	0	1	0	0
RASGEF1A	221002	broad.mit.edu	37	10	43692427	43692427	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr10:43692427C>T	ENST00000395809.1	-	11	3851	c.1345G>A	c.(1345-1347)Gaa>Aaa	p.E449K	RASGEF1A_ENST00000395810.1_Missense_Mutation_p.E449K|RASGEF1A_ENST00000374459.1_Missense_Mutation_p.E457K			Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	449	Ras-GEF.				cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)	11						CCCTCACCTTCCTCGCTGTAG	0.582000													18	24					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597832.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													3	19					0.115264	0.115545	1	1	0
GRIN2A	2903	broad.mit.edu	37	16	10273957	10273957	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:10273957C>T	ENST00000396573.2	-	3	621	c.312G>A	c.(310-312)acG>acA	p.T104T	GRIN2A_ENST00000404927.2_Silent_p.T104T|GRIN2A_ENST00000396575.2_Silent_p.T104T|GRIN2A_ENST00000330684.3_Silent_p.T104T|GRIN2A_ENST00000562109.1_Silent_p.T104T	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	104					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCTCCTGGTCCGTGTCGTCCC	0.602000													71	86					0	0	1	0	0
CCDC180	100499483	broad.mit.edu	37	9	100124563	100124563	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr9:100124563G>A	ENST00000375202.2	+	42	5226	c.3874G>A	c.(3874-3876)Ggc>Agc	p.G1292S	RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000395220.1_Intron|CCDC180_ENST00000529487.1_Missense_Mutation_p.G1292S|CCDC180_ENST00000357054.1_Intron					coiled-coil domain containing 180																		TGGGTCTCGGGGCAGCAGTGA	0.592000													87	16					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003771	122003771	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:122003771G>A	ENST00000498619.1	+	7	3438	c.3000G>A	c.(2998-3000)agG>agA	p.R1000R	CASR_ENST00000296154.5_Silent_p.R990R|CASR_ENST00000490131.1_Silent_p.R990R	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	990					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TGGCCCACAGGAATTCTACGC	0.577000													32	34					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56357849	56357849	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:56357849G>A	ENST00000370754.5	-	84	20339	c.20340C>T	c.(20338-20340)ttC>ttT	p.F6780F	DST_ENST00000361203.3_Silent_p.F6491F|DST_ENST00000370788.2_Silent_p.F4405F|DST_ENST00000244364.6_Silent_p.F4188F|DST_ENST00000370769.4_Silent_p.F6602F|DST_ENST00000421834.2_Silent_p.F4514F|DST_ENST00000446842.2_Silent_p.F6276F|DST_ENST00000312431.6_3'UTR			Q03001	DYST_HUMAN	dystonin	6600					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GAGAATTGTGGAACTCCATTG	0.428000													12	27					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123842581	123842581	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr10:123842581C>T	ENST00000369005.1	+	4	906	c.566C>T	c.(565-567)tCc>tTc	p.S189F	TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515603.1_Missense_Mutation_p.S189F|TACC2_ENST00000453444.2_Missense_Mutation_p.S189F|TACC2_ENST00000515273.1_Missense_Mutation_p.S189F|TACC2_ENST00000334433.3_Missense_Mutation_p.S189F|TACC2_ENST00000513429.1_Intron	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	189						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TCCTCCTTCTCCTTCTCCAGT	0.582000													27	19					0	0	1	0	0
CCDC180	100499483	broad.mit.edu	37	9	100124562	100124562	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr9:100124562G>A	ENST00000375202.2	+	42	5225	c.3873G>A	c.(3871-3873)cgG>cgA	p.R1291R	RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000395220.1_Intron|CCDC180_ENST00000529487.1_Silent_p.R1291R|CCDC180_ENST00000357054.1_Intron					coiled-coil domain containing 180																		GTGGGTCTCGGGGCAGCAGTG	0.587000													86	15					0	0	1	0	0
ITGA6	3655	broad.mit.edu	37	2	173352085	173352085	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:173352085C>T	ENST00000375221.2	+	16	2384	c.2181C>T	c.(2179-2181)ccC>ccT	p.P727P	ITGA6_ENST00000264107.7_Silent_p.P688P|ITGA6_ENST00000409532.1_Silent_p.P569P|ITGA6_ENST00000409080.1_Silent_p.P688P|ITGA6_ENST00000343713.4_Silent_p.P683P|AC093818.1_ENST00000442417.1_RNA|ITGA6_ENST00000264106.6_Silent_p.P727P			P23229	ITA6_HUMAN	integrin, alpha 6	727					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity	p.P688P(1)		NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			CAAGGAATCCCACAAAAGATG	0.408000													51	45					0	0	1	0	0
RHBDD1	84236	broad.mit.edu	37	2	227729455	227729455	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:227729455C>T	ENST00000392062.2	+	4	570	c.46C>T	c.(46-48)Ctt>Ttt	p.L16F	RHBDD1_ENST00000341329.3_Missense_Mutation_p.L16F	NM_001167608.1	NP_001161080.1	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	16						integral to membrane	serine-type endopeptidase activity			breast(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		TATTCTACTCCTTTCTCAAAT	0.458000													76	111					0	0	1	0	0
CXXC4	80319	broad.mit.edu	37	4	105393494	105393494	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr4:105393494G>A	ENST00000394767.2	-	3	1539	c.1089C>T	c.(1087-1089)ttC>ttT	p.F363F	CXXC4_ENST00000426831.1_Silent_p.F194F|CXXC4_ENST00000466963.1_5'UTR	NM_025212.2	NP_079488.2	Q9H2H0	CXXC4_HUMAN	CXXC finger protein 4	194					negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		AGAACCATCGGAATGCTTCAG	0.343000													61	84					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180634402	180634402	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:180634402C>T	ENST00000410066.1	-	3	684	c.81G>A	c.(79-81)gaG>gaA	p.E27E		NM_152520.4	NP_689733.3	Q569K4	Z385B_HUMAN	zinc finger protein 385B	27						nucleus	nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	26			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TTTTCTTTTTCTCTTTGCTCA	0.463000													51	66					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44670091	44670091	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr20:44670091C>T	ENST00000454036.1	+	8	1123	c.1047C>T	c.(1045-1047)ttC>ttT	p.F349F	SLC12A5_ENST00000539566.1_Intron|SLC12A5_ENST00000243964.3_Silent_p.F326F	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	349					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCTCTCGCTTCCTCAACGCCA	0.567000													59	67					0	0	1	0	0
KDM8	79831	broad.mit.edu	37	16	27224962	27224962	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:27224962C>T	ENST00000286096.4	+	3	728	c.555C>T	c.(553-555)ccC>ccT	p.P185P	KDM8_ENST00000441782.2_Silent_p.P223P|KDM8_ENST00000380948.2_Intron|KDM8_ENST00000568965.1_Intron|CTD-3203P2.1_ENST00000567108.1_RNA	NM_024773.2	NP_079049.2	Q8N371	KDM8_HUMAN	lysine (K)-specific demethylase 8	185					G2/M transition of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|histone demethylase activity (H3-K36 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen										AAACAGTCCCCCGGCTGCACC	0.517000													51	85					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13920608	13920608	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr5:13920608C>T	ENST00000265104.4	-	6	883	c.779G>A	c.(778-780)tGg>tAg	p.W260*		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	260	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTGTTTGATCCATACTTTCAT	0.398000									Kartagener syndrome				59	76					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55027511	55027511	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr20:55027511G>A	ENST00000371336.3	+	5	1480	c.1279G>A	c.(1279-1281)Gag>Aag	p.E427K	CASS4_ENST00000360314.3_Missense_Mutation_p.E427K|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	427	Ser-rich.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						CTCTTCCTCGGAGGAGTCAGC	0.567000													18	37					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231162144	231162144	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:231162144G>A	ENST00000392045.3	+	22	2139	c.2025G>A	c.(2023-2025)ctG>ctA	p.L675L	SP140_ENST00000417495.3_Silent_p.L561L|SP140_ENST00000486687.2_Silent_p.L599L|SP140_ENST00000420434.3_Silent_p.L648L|SP140_ENST00000343805.6_Silent_p.L615L|SP140_ENST00000350136.5_Silent_p.L544L	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	675					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGAGAATACTGAAGTCTCAAA	0.338000													33	45					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78443553	78443553	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr11:78443553C>T	ENST00000278550.7	-	21	3408	c.2946G>A	c.(2944-2946)caG>caA	p.Q982Q		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		GGGTGTGCTCCTGTGTGATGA	0.532000													20	49					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103281714	103281714	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:103281714C>T	ENST00000233969.2	+	3	1051	c.909C>T	c.(907-909)acC>acT	p.T303T		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	303						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						CTCGATTCACCCATAATATCC	0.453000													70	87					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167794010	167794010	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:167794010G>A	ENST00000367848.1	-	27	4055	c.3558C>T	c.(3556-3558)gcC>gcT	p.A1186A	ADCY10_ENST00000545172.1_Silent_p.A1125A|ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Silent_p.A1278A			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1278					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TGTGCTCCATGGCCATGACTT	0.493000													157	110					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16026279	16026279	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr8:16026279C>T	ENST00000350896.3	-	4	515	c.318G>A	c.(316-318)gaG>gaA	p.E106E	MSR1_ENST00000381998.4_Silent_p.E106E|MSR1_ENST00000445506.2_Silent_p.E124E|MSR1_ENST00000262101.5_Silent_p.E106E|MSR1_ENST00000536385.1_Intron|MSR1_ENST00000355282.2_Silent_p.E106E	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	106	Spacer (Probable).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATCTCATTTCCTCTTCGCTGT	0.408000													76	107					0	0	1	0	0
SENP2	59343	broad.mit.edu	37	3	185337174	185337174	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:185337174C>T	ENST00000296257.5	+	13	1570	c.1330C>T	c.(1330-1332)Cct>Tct	p.P444S	SENP2_ENST00000545472.1_Missense_Mutation_p.P434S|SENP2_ENST00000427465.2_Missense_Mutation_p.P268S	NM_021627.2	NP_067640.2	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific peptidase 2	444	Protease.				mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(3)	12	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			TTTCTTCTATCCTAAATTAAA	0.368000													26	54					0	0	1	0	0
CCDC64B	146439	broad.mit.edu	37	16	3085469	3085469	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:3085469G>A	ENST00000572449.1	-	2	91	c.29C>T	c.(28-30)cCg>cTg	p.P10L	RP11-473M20.5_ENST00000382225.3_RNA|CCDC64B_ENST00000389347.4_Missense_Mutation_p.P10L			A1A5D9	BICR2_HUMAN	coiled-coil domain containing 64B	10										breast(1)|endometrium(2)|large_intestine(1)	4						CGGCCCGGACGGGAAGCTGGG	0.687000													24	32					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230910901	230910901	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:230910901C>T	ENST00000295190.4	-	4	1399	c.941G>A	c.(940-942)cGa>cAa	p.R314Q		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	314						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TACAAACATTCGATTTGTAAA	0.453000													24	49					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028355	37028355	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:37028355G>A	ENST00000358047.3	+	1	1924	c.1872G>A	c.(1870-1872)gaG>gaA	p.E624E		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	624										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						AGCCTCCTGAGACTGGAGTGT	0.642000													85	98					0	0	1	0	0
GET4	51608	broad.mit.edu	37	7	931927	931927	+	Silent	SNP	A	A	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:931927A>G	ENST00000407192.1	+	5	2976	c.459A>G	c.(457-459)ttA>ttG	p.L153L	GET4_ENST00000265857.3_Silent_p.L206L			Q7L5D6	GET4_HUMAN	golgi to ER traffic protein 4 homolog (S. cerevisiae)	206					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding			breast(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						TTCTCTGTTTAAAAAACAAAA	0.562000													116	221					0	0	1	0	0
C7orf55-LUC7L2	100996928	broad.mit.edu	37	7	139090466	139090466	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:139090466A>T	ENST00000354926.4	+	5	797	c.443A>T	c.(442-444)aAt>aTt	p.N148I	LUC7L2_ENST00000541515.3_Missense_Mutation_p.N214I|C7orf55-LUC7L2_ENST00000541170.3_Missense_Mutation_p.N145I|C7orf55-LUC7L2_ENST00000263545.6_Missense_Mutation_p.N147I	NM_016019.3	NP_057103.2																					GCTGAAGGGAATGTGGAGGAA	0.373000													37	30					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45153717	45153717	+	Silent	SNP	C	C	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:45153717C>A	ENST00000296129.1	-	3	647	c.513G>T	c.(511-513)gtG>gtT	p.V171V	CDCP1_ENST00000425231.2_Silent_p.V171V	NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	171						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		CGATCCTGACCACGGTGGCAT	0.577000													76	112					2.15109e-50	2.23822e-50	1	1	0
DOCK3	1795	broad.mit.edu	37	3	51267026	51267026	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:51267026G>A	ENST00000266037.9	+	19	1926	c.1903G>A	c.(1903-1905)Gag>Aag	p.E635K		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	635	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TGTCAGTGGGGAGGAAATTGT	0.468000													17	19					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102293008	102293008	+	RNA	SNP	A	A	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr15:102293008A>G	ENST00000561463.1	+	0	1054																		p.K171E(1)									GCGTGGGAACAAGAAGACACT	0.582000													3	18					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49737905	49737905	+	Splice_Site	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:49737905G>A	ENST00000327697.6	+	14	1255	c.1110_splice	c.e14-1	p.D371_splice	RNF123_ENST00000432042.1_Splice_Site_p.D225_splice	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	371						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CTTCCCCCAGGACTACGAGGT	0.572000													51	75					0	0	1	0	0
CCNT1	904	broad.mit.edu	37	12	49110387	49110387	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:49110387G>A	ENST00000261900.3	-	1	294	c.72C>T	c.(70-72)tcC>tcT	p.S24S		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	24					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						CAAAACGACGGGATGGGCTAT	0.517000											OREG0021767	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	101	165					0	0	1	0	0
PRSS57	400668	broad.mit.edu	37	19	687185	687185	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:687185T>G	ENST00000329267.7	-	4	414	c.385A>C	c.(385-387)Aac>Cac	p.N129H		NM_214710.3	NP_999875.1	Q6UWY2	PRS57_HUMAN	protease, serine, 57	129	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|lung(5)	6						GCAGAGCCGTTCAGCTGCAGG	0.692000													5	17					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143748366	143748366	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:143748366G>A	ENST00000408906.2	+	1	906	c.872G>A	c.(871-873)aGc>aAc	p.S291N		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					TTGATCTATAGCCTGAGGAAC	0.517000													67	165					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100490199	100490199	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:100490199T>C	ENST00000302913.4	-	3	1447	c.1309A>G	c.(1309-1311)Aat>Gat	p.N437D	ACHE_ENST00000419336.2_Intron|ACHE_ENST00000412389.1_Missense_Mutation_p.N437D|ACHE_ENST00000241069.5_Missense_Mutation_p.N437D|ACHE_ENST00000411582.1_Missense_Mutation_p.N437D|ACHE_ENST00000428317.1_Missense_Mutation_p.N437D	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	437					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	CACACGACATTGTGGTCGCCC	0.672000													24	78					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111317745	111317745	+	Silent	SNP	T	T	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:111317745T>C	ENST00000308208.5	+	6	767	c.525T>C	c.(523-525)aaT>aaC	p.N175N	CCDC63_ENST00000545036.1_Silent_p.N135N|CCDC63_ENST00000552694.1_Silent_p.N96N|CCDC63_ENST00000550317.1_Intron	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	175										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						TGACCACTAATGCCAAGCTCC	0.453000													101	144					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584927	82584927	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:82584927T>C	ENST00000423517.2	-	5	5679	c.5342A>G	c.(5341-5343)gAg>gGg	p.E1781G	PCLO_ENST00000333891.8_Missense_Mutation_p.E1781G	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1712					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTCTTCTTCCTCTCTCAATTC	0.383000													133	69					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58621104	58621104	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:58621104C>T	ENST00000317147.5	-	6	766		c.e6+1		CNOT1_ENST00000569240.1_Splice_Site|CNOT1_ENST00000441024.2_Splice_Site	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AAGTAACTCACCGAAACCTCT	0.363000													30	45					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27761264	27761264	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:27761264G>A	ENST00000261588.4	+	16	3002	c.2983G>A	c.(2983-2985)Gga>Aga	p.G995R		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	995										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						CGGCCTCAACGGAATAGAAAT	0.483000													17	31					0	0	1	0	0
APOBEC3G	60489	broad.mit.edu	37	22	39479784	39479784	+	Silent	SNP	T	T	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr22:39479784T>C	ENST00000407997.3	+	5	987	c.630T>C	c.(628-630)ccT>ccC	p.P210P	APOBEC3G_ENST00000452957.2_Silent_p.P210P|APOBEC3G_ENST00000461827.1_3'UTR	NM_021822.3	NP_068594.1			apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G											central_nervous_system(1)|large_intestine(4)|lung(5)|skin(1)|stomach(1)	12	Melanoma(58;0.04)					ACAATGAACCTTGGGTCAGAG	0.532000													35	91					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25677918	25677918	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr4:25677918C>T	ENST00000382051.3	+	13	1670	c.1620C>T	c.(1618-1620)atC>atT	p.I540I	SLC34A2_ENST00000503434.1_Silent_p.I539I|SLC34A2_ENST00000504570.1_Silent_p.I539I	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	540					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TCTTCCTGATCCCGCTGACGG	0.607000			T	ROS1	NSCLC								93	118					0	0	1	0	0
PBX1	5087	broad.mit.edu	37	1	164769116	164769116	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:164769116C>T	ENST00000420696.2	+	4	879	c.691C>T	c.(691-693)Ctg>Ttg	p.L231L	PBX1_ENST00000540246.1_Silent_p.L126L|PBX1_ENST00000367897.1_Silent_p.L231L|PBX1_ENST00000540236.1_Silent_p.L231L|PBX1_ENST00000560641.1_Silent_p.L126L|PBX1_ENST00000559240.1_Silent_p.L231L|PBX1_ENST00000401534.1_Silent_p.L231L	NM_001204961.1|NM_001204963.1|NM_002585.3	NP_001191890.1|NP_001191892.1|NP_002576.1	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	231					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						TTCCCGATTTCTGGATGCGCG	0.612000			T	"""TCF3, EWSR1"""	"""pre B-ALL, myoepithelioma"""								49	24					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65502060	65502060	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr15:65502060G>A	ENST00000261883.4	-	2	200	c.34C>T	c.(34-36)Ctg>Ttg	p.L12L		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	12					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						TCCAGGACCAGGAAGGAGAAC	0.547000													44	53					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6825346	6825346	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:6825346G>A	ENST00000304076.2	+	8	850	c.756G>A	c.(754-756)aaG>aaA	p.K252K	VAV1_ENST00000602142.1_Silent_p.K252K|VAV1_ENST00000599806.1_Silent_p.K197K|VAV1_ENST00000596764.1_Silent_p.K220K|VAV1_ENST00000539284.1_Silent_p.K155K	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	252	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						ACTTCCTAAAGGAGATGAAGG	0.587000													25	38					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61958165	61958165	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr10:61958165C>T	ENST00000280772.1	-	14	1813	c.1622G>A	c.(1621-1623)cGa>cAa	p.R541Q	ANK3_ENST00000503366.1_Missense_Mutation_p.R524Q|ANK3_ENST00000373827.2_Missense_Mutation_p.R535Q	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	541					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ATGCCCCTCTCGGGCGGAAAG	0.507000													47	49					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136088003	136088003	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:136088003C>T	ENST00000383202.2	-	24	2748	c.2492G>A	c.(2491-2493)aGt>aAt	p.S831N	STAG1_ENST00000236698.5_Missense_Mutation_p.S831N|STAG1_ENST00000536929.1_Missense_Mutation_p.S415N|STAG1_ENST00000434713.2_Missense_Mutation_p.S605N	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	831					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						CATCACAAAACTGAGGAGTTC	0.423000													33	29					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14792848	14792848	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr9:14792848G>A	ENST00000380881.4	-	23	4692	c.3877C>T	c.(3877-3879)Cgt>Tgt	p.R1293C	FREM1_ENST00000380880.3_Missense_Mutation_p.R1292C|FREM1_ENST00000422223.2_Missense_Mutation_p.R1292C			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1292					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		GAAATAATACGAGTTTCACCC	0.368000													6	1					0	0	1	0	0
EFHC2	80258	broad.mit.edu	37	X	44089003	44089003	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:44089003A>C	ENST00000420999.1	-	11	1726	c.1643T>G	c.(1642-1644)cTt>cGt	p.L548R		NM_025184.3	NP_079460.2	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	548							calcium ion binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	29						TTGTAGGGCAAGTTTGAGGTT	0.398000													11	128					0	0	1	0	0
C16orf93	90835	broad.mit.edu	37	16	30768806	30768806	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:30768806C>T	ENST00000543610.1	-	9	1948	c.987G>A	c.(985-987)aaG>aaA	p.K329K	PHKG2_ENST00000563588.1_3'UTR|PHKG2_ENST00000424889.3_Intron|C16orf93_ENST00000541260.1_Silent_p.K394K	NM_001014979.2	NP_001014979.2	A1A4V9	CP093_HUMAN	chromosome 16 open reading frame 93	329										breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(6)	11						GTCACTTGGTCTTGCTCTTGC	0.587000													171	222					0	0	1	0	0
SIK1	150094	broad.mit.edu	37	21	44846015	44846015	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr21:44846015C>T	ENST00000270162.6	-	2	176	c.44G>A	c.(43-45)gGt>gAt	p.G15D		NM_173354.3	NP_775490.2	P57059	SIK1_HUMAN	salt-inducible kinase 1	15			G -> S (in dbSNP:rs3746951).		anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|testis(2)|urinary_tract(1)	21						CTGGCCCTGACCCTGGCCCGC	0.692000													4	1					0	0	1	0	0
FUT2	2524	broad.mit.edu	37	19	49207099	49207099	+	Missense_Mutation	SNP	G	G	A	rs79097987		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:49207099G>A	ENST00000425340.2	+	2	1003	c.886G>A	c.(886-888)Gca>Aca	p.A296T	FUT2_ENST00000391876.4_Missense_Mutation_p.A296T	NM_000511.5|NM_001097638.2	NP_000502.4|NP_001091107.1	Q10981	FUT2_HUMAN	fucosyltransferase 2 (secretor status included)	296					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)	7		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		GATCTGGGCCGCATACCTCAC	0.557000													5	199					0	0	1	0	0
MRO	83876	broad.mit.edu	37	18	48327809	48327809	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr18:48327809C>T	ENST00000428869.2	-	7	753	c.495G>A	c.(493-495)agG>agA	p.R165R	MRO_ENST00000588444.1_Intron|MRO_ENST00000587291.1_5'UTR|MRO_ENST00000256425.2_Silent_p.R165R|MRO_ENST00000398439.3_Silent_p.R165R|MRO_ENST00000436348.2_Silent_p.R179R|MRO_ENST00000431965.2_Intron			Q9BYG7	MSTRO_HUMAN	maestro	165						nucleolus	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|skin(2)	10		Colorectal(6;0.0596)		Colorectal(21;0.082)		TTTTCCATTTCCTCCCGGCAA	0.468000													101	103					0	0	1	0	0
IGHV1OR15-9	390531	broad.mit.edu	37	15	20170146	20170146	+	RNA	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr15:20170146C>T	ENST00000338912.5	-	0	125																											ATCCAGAAGCCTTGCAGGAGA	0.582000													77	72					0	0	1	0	0
SLC34A1	6569	broad.mit.edu	37	5	176824842	176824842	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr5:176824842C>T	ENST00000324417.5	+	13	1566	c.1475C>T	c.(1474-1476)cCc>cTc	p.P492L	SLC34A1_ENST00000513614.1_3'UTR	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	492					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TACCCGGTGCCCTGCACACGC	0.607000													49	86					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	109782121	109782121	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr4:109782121G>A	ENST00000399132.1	-	23	1734	c.1204C>T	c.(1204-1206)Cgt>Tgt	p.R402C	COL25A1_ENST00000399127.1_Missense_Mutation_p.R383C|COL25A1_ENST00000399126.1_Missense_Mutation_p.R402C	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	402	Collagen-like 5.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		TTTTCTCCACGATCCCCCTTT	0.438000													31	42					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123842582	123842582	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr10:123842582C>T	ENST00000369005.1	+	4	907	c.567C>T	c.(565-567)tcC>tcT	p.S189S	TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515603.1_Silent_p.S189S|TACC2_ENST00000453444.2_Silent_p.S189S|TACC2_ENST00000515273.1_Silent_p.S189S|TACC2_ENST00000334433.3_Silent_p.S189S|TACC2_ENST00000513429.1_Intron	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	189						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCTCCTTCTCCTTCTCCAGTG	0.577000													28	19					0	0	1	0	0
MKS1	54903	broad.mit.edu	37	17	56291167	56291167	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:56291167G>A	ENST00000393119.2	-	7	782	c.708C>T	c.(706-708)atC>atT	p.I236I	MKS1_ENST00000313863.6_Silent_p.I236I|MKS1_ENST00000537529.2_Silent_p.I226I|MKS1_ENST00000337050.7_Silent_p.I236I|MKS1_ENST00000546108.1_Silent_p.I33I	NM_017777.3	NP_060247.2	Q9NXB0	MKS1_HUMAN	Meckel syndrome, type 1	236					cilium assembly	centrosome|cilium|microtubule basal body	protein binding			endometrium(5)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						GCTTTACTGTGATCACACCAT	0.478000													40	54					0	0	1	0	0
CLDN6	9074	broad.mit.edu	37	16	3065466	3065466	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:3065466G>A	ENST00000396925.1	-	3	985	c.557C>T	c.(556-558)cCc>cTc	p.P186L	CLDN6_ENST00000572154.1_Intron|CLDN6_ENST00000328796.4_Missense_Mutation_p.P186L			P56747	CLD6_HUMAN	claudin 6	186					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	10						CCCCCCCGAGGGGCAAGTGCA	0.652000													26	40					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67801047	67801047	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr13:67801047C>T	ENST00000544246.1	-	2	2217	c.1526G>A	c.(1525-1527)gGa>gAa	p.G509E	PCDH9_ENST00000377861.3_Missense_Mutation_p.G509E|PCDH9_ENST00000456367.1_Missense_Mutation_p.G509E|PCDH9_ENST00000328454.5_Missense_Mutation_p.G509E|PCDH9_ENST00000377865.2_Missense_Mutation_p.G509E	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	509	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GGCATTCGGTCCAAGCTGATA	0.408000													39	36					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110420353	110420353	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr8:110420353G>A	ENST00000378402.5	+	18	1993	c.1889G>A	c.(1888-1890)gGa>gAa	p.G630E		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	630					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CAAACCAAAGGAAAACCCAAC	0.403000										HNSCC(38;0.096)			29	31					0	0	1	0	0
EIF2AK3	9451	broad.mit.edu	37	2	88887529	88887529	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:88887529C>T	ENST00000303236.3	-	8	1701	c.1400G>A	c.(1399-1401)gGt>gAt	p.G467D	EIF2AK3_ENST00000419748.1_Missense_Mutation_p.G316D	NM_004836.5	NP_004827.4	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 3	467					activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						TGAAAGTGCACCATTACTATA	0.284000													19	29					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53045768	53045768	+	Silent	SNP	G	G	A	rs142748186	byFrequency	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:53045768G>A	ENST00000309680.3	-	1	180	c.159C>T	c.(157-159)ttC>ttT	p.F53F		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	53	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		CGCCTCCACCGAAGCCCCCGC	0.632000													31	32					0	0	1	0	0
NKX2-2	4821	broad.mit.edu	37	20	21492584	21492584	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr20:21492584G>A	ENST00000377142.4	-	2	1155	c.799C>T	c.(799-801)Cag>Tag	p.Q267*	NKX2-2-AS1_ENST00000549659.1_RNA	NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	267					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						TGCTGGGCCTGGACCAGGGGG	0.711000													28	40					0	0	1	0	0
PDPR	55066	broad.mit.edu	37	16	70162917	70162917	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:70162917C>T	ENST00000288050.4	+	6	1456	c.499C>T	c.(499-501)Cat>Tat	p.H167Y	PDPR_ENST00000398122.3_Missense_Mutation_p.H67Y|PDPR_ENST00000568530.1_Missense_Mutation_p.H167Y	NM_017990.3	NP_060460.4	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory subunit	167					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		CGAGCTTCACCATCTCCTCAA	0.562000													66	365					0	0	1	0	0
ZNF468	90333	broad.mit.edu	37	19	53344021	53344021	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:53344021G>A	ENST00000595646.1	-	4	1646	c.1526C>T	c.(1525-1527)tCc>tTc	p.S509F	ZNF468_ENST00000396409.4_Missense_Mutation_p.S456F|ZNF468_ENST00000390651.4_Missense_Mutation_p.S456F|ZNF468_ENST00000243639.4_3'UTR|ZNF28_ENST00000594602.1_Intron			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	509					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		GTATACAAGGGATGACATCTG	0.428000													108	143					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76893588	76893588	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr11:76893588G>A	ENST00000409709.3	+	25	3500	c.3228G>A	c.(3226-3228)gaG>gaA	p.E1076E	MYO7A_ENST00000409619.2_Silent_p.E1065E|MYO7A_ENST00000458637.2_Silent_p.E1076E|MYO7A_ENST00000409893.1_Silent_p.E1076E	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1076	MyTH4 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						AGATTTATGAGACCCTGGGCA	0.597000													82	35					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33136331	33136331	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:33136331C>T	ENST00000341947.2	-	54	4152	c.3925G>A	c.(3925-3927)Ggg>Agg	p.G1309R	COL11A2_ENST00000374712.1_Missense_Mutation_p.G1228R|COL11A2_ENST00000395197.1_Missense_Mutation_p.G1249R|COL11A2_ENST00000374708.4_Missense_Mutation_p.G1223R|COL11A2_ENST00000374713.1_Missense_Mutation_p.G1262R|COL11A2_ENST00000374714.1_Missense_Mutation_p.G1283R|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000357486.1_Missense_Mutation_p.G1288R|COL11A2_ENST00000361917.1_Missense_Mutation_p.G1202R	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1309	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging	p.G1309R(1)		biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CCATTCTCCCCGGTGGGACCA	0.632000													26	31					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42563530	42563530	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:42563530C>T	ENST00000262895.3	-	5	657	c.658G>A	c.(658-660)Gcc>Acc	p.A220T	GRIK5_ENST00000593562.1_Missense_Mutation_p.A220T|GRIK5_ENST00000301218.4_Missense_Mutation_p.A220T	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	220						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GAGATGGAGGCGTTGGCGTCG	0.582000													48	67					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459922	66459922	+	RNA	SNP	A	A	T	rs145161395	by1000genomes	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr9:66459922A>T	ENST00000424345.1	+	0	182																											ggcatgcagcaccatatgaga	0.363000													3	7					0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88417024	88417024	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr14:88417024G>A	ENST00000261304.2	-	11	1336	c.1230C>T	c.(1228-1230)acC>acT	p.T410T	GALC_ENST00000393568.4_Silent_p.T387T|GALC_ENST00000544807.2_Silent_p.T354T|GALC_ENST00000393569.2_Silent_p.T384T	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	410					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TAAGAACAAAGGTGGCAAATT	0.289000													22	32					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77387774	77387774	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:77387774C>T	ENST00000282849.5	-	10	1888	c.1470G>A	c.(1468-1470)caG>caA	p.Q490Q		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	490	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GACACCCCGCCTGAGGTGTGC	0.423000													68	79					0	0	1	0	0
TRMT10A	93587	broad.mit.edu	37	4	100480508	100480508	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr4:100480508C>T	ENST00000273962.3	-	2	301		c.e2-1		TRMT10A_ENST00000394876.2_5'UTR|TRMT10A_ENST00000394877.3_Splice_Site	NM_152292.4	NP_689505.1			tRNA methyltransferase 10 homolog A (S. cerevisiae)																		TTTGGTGCCTCTGAAAAACAA	0.284000													23	32					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906829	13906829	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:13906829G>A	ENST00000279593.3	-	3	641	c.432C>T	c.(430-432)ttC>ttT	p.F144F		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	144					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGCCAAACTGGAAGAACATGG	0.393000													16	26					0	0	1	0	0
MIR323A	442897	broad.mit.edu	37	14	101492103	101492103	+	RNA	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr14:101492103C>T	ENST00000362199.1	+	0	35					NR_029890.1																						GTGGCGCGTTCGCTTTATTTA	0.552000													76	110					0	0	1	0	0
LBR	3930	broad.mit.edu	37	1	225591019	225591019	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:225591019G>A	ENST00000338179.2	-	14	1959	c.1834C>T	c.(1834-1836)Cca>Tca	p.P612S	LBR_ENST00000272163.4_Missense_Mutation_p.P612S	NM_194442.2	NP_919424.1	Q14739	LBR_HUMAN	lamin B receptor	612					cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		TAGATGTATGGAAATATACGG	0.433000													74	55					0	0	1	0	0
OR6S1	341799	broad.mit.edu	37	14	21109121	21109121	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr14:21109121A>C	ENST00000320704.3	-	1	729	c.730T>G	c.(730-732)Tgt>Ggt	p.C244G		NM_001001968.1	NP_001001968.1	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S, member 1	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		TGGGAGGTACAGGTAGAGAAG	0.532000													56	79					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119456780	119456780	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:119456780C>T	ENST00000369429.3	-	6	893	c.884G>A	c.(883-885)cGa>cAa	p.R295Q	TBX15_ENST00000207157.3_Missense_Mutation_p.R189Q			Q96SF7	TBX15_HUMAN	T-box 15	295						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		AAAAGGGTTTCGGTCAATTTT	0.338000													24	39					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102304772	102304772	+	RNA	SNP	T	T	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr15:102304772T>C	ENST00000561463.1	+	0	12818																											CACAGCGGCGTGACGAGACTC	0.587000													5	30					0	0	1	0	0
TOP3B	8940	broad.mit.edu	37	22	22318362	22318362	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr22:22318362C>T	ENST00000398793.2	-	11	1571	c.1137G>A	c.(1135-1137)cgG>cgA	p.R379R	TOP3B_ENST00000357179.5_Silent_p.R379R|TOP3B_ENST00000413067.2_Silent_p.R108R	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	379					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		CATGGCCTTTCCGCGGGCGGT	0.612000													40	97					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17052041	17052041	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:17052041C>T	ENST00000418129.2	+	2	1290	c.825C>T	c.(823-825)tcC>tcT	p.S275S	PLCL2_ENST00000432376.1_Silent_p.S275S|PLCL2_ENST00000396755.2_Silent_p.S275S|PLCL2_ENST00000460467.1_Intron	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	401					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						GCTGGCTCTCCATAGACGGGT	0.413000													53	78					0	0	1	0	0
DEFA4	1669	broad.mit.edu	37	8	6794287	6794287	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr8:6794287G>A	ENST00000297435.2	-	2	259	c.135C>T	c.(133-135)tcC>tcT	p.S45S		NM_001925.1	NP_001916.1	P12838	DEF4_HUMAN	defensin, alpha 4, corticostatin	45					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	10				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		CCCATGCAAAGGAAATAGATA	0.562000													48	67					0	0	1	0	0
PSKH2	85481	broad.mit.edu	37	8	87081704	87081704	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr8:87081704G>A	ENST00000276616.2	-	1	222	c.148C>T	c.(148-150)Cgc>Tgc	p.R50C	PSKH2_ENST00000517981.1_Intron	NM_033126.1	NP_149117.1	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	50							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|kidney(11)|large_intestine(2)|lung(26)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(1)	47			STAD - Stomach adenocarcinoma(118;0.129)			GCTCGGAAGCGAGCCACCTGT	0.672000													27	25					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40044134	40044134	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:40044134A>G	ENST00000324616.5	+	7	818	c.664A>G	c.(664-666)Aca>Gca	p.T222A	C12orf40_ENST00000398716.1_Missense_Mutation_p.T145A|C12orf40_ENST00000405531.3_Missense_Mutation_p.T222A	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	222										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						ACGATTTGGGACATTATTTGA	0.328000													21	29					0	0	1	0	0
TMEM130	222865	broad.mit.edu	37	7	98460948	98460948	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:98460948A>T	ENST00000339375.4	-	2	335	c.161T>A	c.(160-162)gTg>gAg	p.V54E	TMEM130_ENST00000546258.1_Missense_Mutation_p.V35E|TMEM130_ENST00000345589.4_Intron|TMEM130_ENST00000416379.2_Missense_Mutation_p.V54E|TMEM130_ENST00000450876.1_5'UTR	NM_001134450.1|NM_152913.2	NP_001127922.1|NP_690877.1	Q8N3G9	TM130_HUMAN	transmembrane protein 130	54						Golgi membrane|integral to membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	25	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GTCCTTGGCCACCAGGCTGGC	0.617000													43	19					0	0	1	0	0
BCOR	54880	broad.mit.edu	37	X	39923819	39923819	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:39923819G>A	ENST00000342274.4	-	7	3634	c.3272C>T	c.(3271-3273)cCc>cTc	p.P1091L	BCOR_ENST00000378455.4_Missense_Mutation_p.P1073L|BCOR_ENST00000397354.3_Missense_Mutation_p.P1091L|BCOR_ENST00000378444.4_Missense_Mutation_p.P1091L|BCOR_ENST00000378463.1_5'UTR	NM_001123383.1	NP_001116855.1	Q6W2J9	BCOR_HUMAN	BCL6 corepressor	1091					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						GGCTTCAAAGGGATCACGGTG	0.572000			"""F, N, S, T"""	RARA	"""retinoblastoma, AML, APL(translocation)"""		oculo-facio-cardio-dental genetic						53	80					0	0	1	0	0
MAPK3	5595	broad.mit.edu	37	16	30129473	30129473	+	Silent	SNP	G	G	A	rs143182888		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:30129473G>A	ENST00000484663.1	-	3	1346	c.213C>T	c.(211-213)ttC>ttT	p.F71F	MAPK3_ENST00000395200.1_Intron|MAPK3_ENST00000322266.5_Silent_p.F185F|MAPK3_ENST00000395199.3_Silent_p.F185F|MAPK3_ENST00000395202.1_Silent_p.F185F|MAPK3_ENST00000403394.1_Silent_p.F185F|MAPK3_ENST00000263025.4_Silent_p.F185F			P27361	MK03_HUMAN	mitogen-activated protein kinase 3	185	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding									Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	GGGCCAGGCCGAAATCACAAA	0.592000													24	38					0	0	1	0	0
E2F1	1869	broad.mit.edu	37	20	32264636	32264636	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr20:32264636G>A	ENST00000343380.5	-	7	1355	c.1216C>T	c.(1216-1218)Cac>Tac	p.H406Y		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	406	Transactivation.				apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						AGGGCCTCGTGGGGTGGGGAA	0.652000													8	2					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382915	22382915	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr15:22382915T>C	ENST00000328795.4	+	1	534	c.443T>C	c.(442-444)cTg>cCg	p.L148P	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		ATGTTGGCTCTGTGGCTTGGG	0.527000													88	93					0	0	1	0	0
CHST4	10164	broad.mit.edu	37	16	71571018	71571018	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:71571018C>T	ENST00000338482.5	+	3	781	c.438C>T	c.(436-438)atC>atT	p.I146I	CHST4_ENST00000539698.3_Silent_p.I146I|CHST4_ENST00000572450.1_Silent_p.I146I|RP11-510M2.9_ENST00000572693.1_RNA|ZNF19_ENST00000568446.1_Intron			Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4	146					cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	21						AAGATGAAATCATCCCCCGGG	0.607000													52	47					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72188353	72188353	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:72188353C>T	ENST00000537465.1	-	4	329	c.171G>A	c.(169-171)aaG>aaA	p.K57K	PMFBP1_ENST00000355636.6_5'UTR|PMFBP1_ENST00000237353.10_Silent_p.K57K|PMFBP1_ENST00000543746.1_5'UTR			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	57										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				GTGCTTGCTTCTTGTCCTACC	0.398000													55	75					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52535546	52535546	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr14:52535546G>A	ENST00000216286.5	-	1	166	c.167C>T	c.(166-168)tCa>tTa	p.S56L	NID2_ENST00000541773.1_Intron	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	56						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CACCACGGCTGAGCTTTCGTC	0.622000													34	58					0	0	1	0	0
MAPK6	5597	broad.mit.edu	37	15	52356806	52356806	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr15:52356806C>T	ENST00000261845.5	+	6	2582	c.1775C>T	c.(1774-1776)tCt>tTt	p.S592F	CTD-2184D3.5_ENST00000558607.1_RNA	NM_002748.3	NP_002739.1	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	592					cell cycle		ATP binding|MAP kinase activity			breast(3)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	20				all cancers(107;0.0028)		TACCAGTCTTCTTGGGACAGC	0.393000													37	56					0	0	1	0	0
KLRC3	3823	broad.mit.edu	37	12	10569334	10569334	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:10569334C>T	ENST00000396439.2	-	5	563	c.519G>A	c.(517-519)tgG>tgA	p.W173*	KLRC3_ENST00000381904.2_Nonsense_Mutation_p.W173*|KLRC3_ENST00000381903.2_Nonsense_Mutation_p.W173*|NKG2-E_ENST00000539033.1_Nonsense_Mutation_p.W173*	NM_002261.2	NP_002252.2			killer cell lectin-like receptor subfamily C, member 3											large_intestine(2)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11						ACACACCAATCCATGAGGAAG	0.289000													34	36					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86267562	86267562	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:86267562G>A	ENST00000263857.6	-	25	4071	c.3693C>T	c.(3691-3693)ttC>ttT	p.F1231F	POLR1A_ENST00000409681.1_Silent_p.F1231F			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	1231					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						CTGCAAAGTGGAAGGTGTTGA	0.632000													21	25					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152129196	152129196	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:152129196C>T	ENST00000316073.3	-	3	443	c.379G>A	c.(379-381)Gaa>Aaa	p.E127K		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	127	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TGCCTTTCTTCCTCGTGCCTC	0.542000													157	322					0	0	1	0	0
P4HA3	283208	broad.mit.edu	37	11	74009388	74009388	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr11:74009388C>T	ENST00000331597.4	-	4	631	c.586G>A	c.(586-588)Gat>Aat	p.D196N	P4HA3_ENST00000427714.2_Missense_Mutation_p.D196N	NM_182904.3	NP_878907.1	Q7Z4N8	P4HA3_HUMAN	prolyl 4-hydroxylase, alpha polypeptide III	196						endoplasmic reticulum lumen	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(1)	15	Breast(11;2.31e-05)					TGGTAATAATCCCCCATGTCA	0.468000													187	91					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49063569	49063569	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:49063569C>T	ENST00000376265.2	-	44	5222	c.5161G>A	c.(5161-5163)Ggc>Agc	p.G1721S	CACNA1F_ENST00000376251.1_Missense_Mutation_p.G1656S|CACNA1F_ENST00000323022.5_Missense_Mutation_p.G1710S	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1721					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	GCCCCAGAGCCTCTCCTGGGG	0.537000													7	10					0	0	1	0	0
DPEP3	64180	broad.mit.edu	37	16	68011630	68011630	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:68011630T>G	ENST00000268793.4	-	6	1307	c.934A>C	c.(934-936)Atc>Ctc	p.I312L		NM_001129758.1|NM_022357.3	NP_001123230.1|NP_071752.3	Q9H4B8	DPEP3_HUMAN	dipeptidase 3	287				Missing (in Ref. 2; AAQ88756).	meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(4)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		TGGGAGAAGATCACAGGAGCC	0.502000													9	19					0	0	1	0	0
ZNF30	90075	broad.mit.edu	37	19	35420855	35420855	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:35420855G>A	ENST00000439785.1	+	2	448	c.4G>A	c.(4-6)Gcc>Acc	p.A2T	ZNF30_ENST00000303586.7_Missense_Mutation_p.A2T|ZNF30_ENST00000601540.1_3'UTR|ZNF30_ENST00000601142.1_Missense_Mutation_p.A2T|ZNF30_ENST00000601957.1_Missense_Mutation_p.A2T|ZNF30_ENST00000426813.2_5'UTR	NM_001099438.1	NP_001092908.1	P17039	ZNF30_HUMAN	zinc finger protein 30	2					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)	16	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		TCAAAGCATGGCCCATGTAAG	0.383000													4	14					0	0	1	0	0
USP40	55230	broad.mit.edu	37	2	234394515	234394515	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:234394515G>A	ENST00000251722.6	-	29	3420	c.3303C>T	c.(3301-3303)tcC>tcT	p.S1101S	USP40_ENST00000427112.2_Silent_p.S1101S|USP40_ENST00000496298.1_5'UTR|USP40_ENST00000450966.1_Silent_p.S1113S			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	1101					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		TCTGCCTCAGGGAGCCGGCAG	0.572000													9	11					0	0	1	0	0
CHTF18	63922	broad.mit.edu	37	16	839607	839607	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:839607C>T	ENST00000317063.6	+	5	1089	c.1089C>T	c.(1087-1089)ccC>ccT	p.P363P	CHTF18_ENST00000455171.2_Silent_p.P194P|CHTF18_ENST00000262315.9_Silent_p.P166P|CHTF18_ENST00000491530.1_3'UTR			Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	166					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			endometrium(1)|kidney(3)|liver(2)|lung(4)|prostate(1)	11		Hepatocellular(780;0.00335)				CCCGCAATCCCGTCCTGAGGC	0.657000													32	62					0	0	1	0	0
EPB41	2035	broad.mit.edu	37	1	29323784	29323784	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:29323784G>A	ENST00000343067.4	+	4	866	c.739G>A	c.(739-741)Gaa>Aaa	p.E247K	EPB41_ENST00000356093.2_Missense_Mutation_p.E247K|EPB41_ENST00000373798.1_Missense_Mutation_p.E247K|EPB41_ENST00000347529.3_Intron|EPB41_ENST00000373800.3_Missense_Mutation_p.E38K|EPB41_ENST00000373797.1_Missense_Mutation_p.E247K|EPB41_ENST00000349460.4_Missense_Mutation_p.E38K|EPB41_ENST00000398863.2_Missense_Mutation_p.E247K	NM_001166005.1	NP_001159477.1	P11171	41_HUMAN	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	247	FERM.				blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|urinary_tract(1)	14		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		CAATCTTTTGGAAGAAGACTA	0.363000													43	59					0	0	1	0	0
RALB	5899	broad.mit.edu	37	2	121043649	121043649	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:121043649C>T	ENST00000272519.5	+	3	584	c.314C>T	c.(313-315)gCc>gTc	p.A105V	RALB_ENST00000404963.3_Missense_Mutation_p.A126V|RALB_ENST00000470417.1_3'UTR|RALB_ENST00000420510.1_Missense_Mutation_p.A105V|RALB_ENST00000474855.2_Missense_Mutation_p.A127V	NM_002881.2	NP_002872.1	P11234	RALB_HUMAN	v-ral simian leukemia viral oncogene homolog B	105					apoptosis|cell cycle|cytokinesis|nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of exocyst assembly|regulation of exocyst localization	cytosol|midbody|plasma membrane	GTP binding|GTPase activity|protein binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(154;0.122)				ACAGCAACTGCCGAATTCAGG	0.443000													38	39					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71347468	71347468	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr4:71347468C>T	ENST00000413702.1	+	4	1295	c.1007C>T	c.(1006-1008)tCg>tTg	p.S336L	MUC7_ENST00000456088.1_Missense_Mutation_p.S336L|MUC7_ENST00000304887.5_Missense_Mutation_p.S336L	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	336	Thr-rich.					extracellular region	protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			ACTACTACTTCGGTCACTACT	0.413000													92	114					0	0	1	0	0
ARRDC5	645432	broad.mit.edu	37	19	4891505	4891505	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:4891505C>T	ENST00000381781.2	-	3	581	c.582G>A	c.(580-582)atG>atA	p.M194I		NM_001080523.1	NP_001073992.1	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	194					signal transduction					endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		TGTTCCTTTCCATCTGGATTT	0.527000													19	21					0	0	1	0	0
GEMIN7	79760	broad.mit.edu	37	19	45593517	45593517	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:45593517G>A	ENST00000270257.4	+	3	392	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	GEMIN7_ENST00000391951.2_Missense_Mutation_p.E49K|GEMIN7_ENST00000591747.1_Missense_Mutation_p.E49K|GEMIN7_ENST00000591607.1_Missense_Mutation_p.E49K|CTB-179K24.4_ENST00000586744.1_RNA|CTB-179K24.3_ENST00000586556.1_RNA	NM_001007269.1|NM_001007270.1|NM_024707.2	NP_001007270.1|NP_001007271.1|NP_078983.1	Q9H840	GEMI7_HUMAN	gem (nuclear organelle) associated protein 7	49					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			endometrium(1)|kidney(1)|lung(4)|ovary(1)	7		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		CATAGCTCAAGAATCCCTGGA	0.632000													41	54					0	0	1	0	0
CD1B	910	broad.mit.edu	37	1	158300844	158300844	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:158300844C>T	ENST00000368168.3	-	2	177	c.70G>A	c.(70-72)Ggg>Agg	p.G24R		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	24					antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					GAGGTCGGCCCCTGGAAGGCT	0.448000													120	272					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125521355	125521355	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:125521355C>T	ENST00000431078.1	+	15	2702	c.2338C>T	c.(2338-2340)Ccc>Tcc	p.P780S		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	780	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		GAGAATTGGTCCCTTGCGTTG	0.443000													14	13					0	0	1	0	0
TNPO2	30000	broad.mit.edu	37	19	12817567	12817567	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:12817567G>C	ENST00000425528.1	-	14	1670	c.1313C>G	c.(1312-1314)cCg>cGg	p.P438R	TNPO2_ENST00000592287.1_Missense_Mutation_p.P438R|TNPO2_ENST00000588216.1_Missense_Mutation_p.P438R|TNPO2_ENST00000450764.2_Missense_Mutation_p.P438R|TNPO2_ENST00000356861.5_Missense_Mutation_p.P438R|TNPO2_ENST00000441499.1_Missense_Mutation_p.P438R			O14787	TNPO2_HUMAN	transportin 2	438					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GATCAGGTGCGGGATCAGCTC	0.632000													11	18					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185138840	185138840	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr4:185138840C>T	ENST00000296741.2	-	1	274	c.133G>A	c.(133-135)Gag>Aag	p.E45K		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	45					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		GGCAATGACTCCAGCGCCTCA	0.532000													34	50					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168098258	168098258	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr5:168098258C>T	ENST00000519560.1	-	34	4491	c.4072G>A	c.(4072-4074)Ggc>Agc	p.G1358S	SLIT3_ENST00000404867.3_Missense_Mutation_p.G1358S|SLIT3_ENST00000332966.8_Missense_Mutation_p.G1365S	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1358	EGF-like 7.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCGGTCCAGCCTGGGCGGCAC	0.687000													28	10					0	0	1	0	0
PDE6D	5147	broad.mit.edu	37	2	232602838	232602838	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:232602838G>A	ENST00000287600.4	-	3	344	c.150C>T	c.(148-150)ccC>ccT	p.P50P	PDE6D_ENST00000409772.1_Silent_p.P50P	NM_002601.2	NP_002592.1	O43924	PDE6D_HUMAN	phosphodiesterase 6D, cGMP-specific, rod, delta	50					regulation of GTP catabolic process|response to stimulus|visual perception		3',5'-cyclic-nucleotide phosphodiesterase activity|GTPase inhibitor activity|protein binding			endometrium(1)|large_intestine(1)|lung(2)|skin(1)	5		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.142)		Epithelial(121;2.19e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00145)|LUSC - Lung squamous cell carcinoma(224;0.0125)|Lung(119;0.0154)		GGATTTTCTTGGGAACACGGG	0.393000													56	92					0	0	1	0	0
ZNF787	126208	broad.mit.edu	37	19	56599602	56599602	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:56599602C>T	ENST00000270459.3	-	3	1057	c.939G>A	c.(937-939)gaG>gaA	p.E313E		NM_001002836.2	NP_001002836.2	Q6DD87	ZN787_HUMAN	zinc finger protein 787	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|lung(2)|pancreas(1)	5		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0559)		GGGCCGGCTCCTCGCCCCCCG	0.756000													6	11					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3200831	3200831	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr8:3200831G>A	ENST00000520002.1	-	24	4174	c.3619C>T	c.(3619-3621)Caa>Taa	p.Q1207*	CSMD1_ENST00000400186.3_Nonsense_Mutation_p.Q1207*|CSMD1_ENST00000537824.1_Nonsense_Mutation_p.Q1206*|CSMD1_ENST00000542608.1_Nonsense_Mutation_p.Q1206*|CSMD1_ENST00000539096.1_Nonsense_Mutation_p.Q1206*|CSMD1_ENST00000602557.1_Nonsense_Mutation_p.Q1207*|CSMD1_ENST00000602723.1_Nonsense_Mutation_p.Q1207*			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1207	CUB 7.					integral to membrane		p.Q935*(1)|p.Q1206*(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TAGGTGAGTTGAAAACCTTGG	0.373000													27	53					0	0	1	0	0
PRODH2	58510	broad.mit.edu	37	19	36304172	36304172	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:36304172C>T	ENST00000301175.3	-	1	29	c.12G>A	c.(10-12)agG>agA	p.R4R		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	4					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ttgagactaccctgggcgaca	0.458000													10	18					0	0	1	0	0
ADRA2A	150	broad.mit.edu	37	10	112838012	112838012	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr10:112838012C>T	ENST00000280155.2	+	1	1223	c.258C>T	c.(256-258)ttC>ttT	p.F86F		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	71					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding			breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	AAAACCTCTTCCTGGTGTCTC	0.637000													16	28					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129899738	129899738	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr10:129899738C>T	ENST00000368654.3	-	14	9864	c.9489G>A	c.(9487-9489)gaG>gaA	p.E3163E	MKI67_ENST00000368653.3_Silent_p.E2803E	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	3163					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GCTGGGAGCTCTCATTCTGTC	0.498000													76	94					0	0	1	0	0
NANOS3	342977	broad.mit.edu	37	19	13988377	13988377	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:13988377C>T	ENST00000397555.2	+	2	258	c.258C>T	c.(256-258)ccC>ccT	p.P86P	NANOS3_ENST00000339133.5_Silent_p.P105P|NANOS3_ENST00000591161.1_Intron|NANOS3_ENST00000591727.1_Intron	NM_001098622.2	NP_001092092.1	P60323	NANO3_HUMAN	nanos homolog 3 (Drosophila)	86					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			breast(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	7			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			TGCTGTGTCCCATCCTGCGGG	0.652000													19	44					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21232695	21232695	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:21232695C>T	ENST00000233242.1	-	26	7172	c.7045G>A	c.(7045-7047)Gaa>Aaa	p.E2349K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2349					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGTCTACTTCATACCTCTCG	0.378000													52	47					0	0	1	0	0
GML	2765	broad.mit.edu	37	8	143927825	143927825	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr8:143927825G>A	ENST00000220940.1	+	4	286	c.196G>A	c.(196-198)Gaa>Aaa	p.E66K		NM_002066.2	NP_002057.1	Q99445	GML_HUMAN	glycosylphosphatidylinositol anchored molecule like	66	UPAR/Ly6.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation	anchored to membrane|extrinsic to membrane|plasma membrane				NS(1)|central_nervous_system(2)|endometrium(1)|large_intestine(6)|lung(8)	18	all_cancers(97;4.26e-11)|all_epithelial(106;1.85e-08)|Lung NSC(106;0.000274)|all_lung(105;0.000755)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					AAATTCTCGTGAACTACTTGT	0.348000													24	44					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12123600	12123600	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:12123600C>T	ENST00000379388.2	+	4	3904	c.3572C>T	c.(3571-3573)tCt>tTt	p.S1191F		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1191					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CGGGACGGGTCTCATCCTCAC	0.512000													27	40					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179430001	179430001	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:179430001G>A	ENST00000589042.1	-	326	81082	c.80858C>T	c.(80857-80859)aCg>aTg	p.T26953M	TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.T25312M|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.T24385M|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.T18080M|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.T17888M|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.T18013M	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25312	Fibronectin type-III 96.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTGTTGCCGTTACGGTGTA	0.403000													4	146					0	0	1	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891656	18891656	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:18891656A>T	ENST00000317658.3	+	1	612	c.454A>T	c.(454-456)Ata>Tta	p.I152L		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	152					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				GGAGTACTTGATAGCTTGCAT	0.383000													16	91					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004145	75004145	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:75004145C>T	ENST00000373359.2	-	1	934	c.742G>A	c.(742-744)Gag>Aag	p.E248K		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	248	MAGE 1.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AACTCAAACTCAAGGGGATTA	0.498000													39	70					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79579662	79579662	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr10:79579662G>A	ENST00000372391.2	-	16	3522	c.3517C>T	c.(3517-3519)Ccg>Tcg	p.P1173S	DLG5_ENST00000372388.2_Missense_Mutation_p.P833S|DLG5_ENST00000459739.1_5'UTR	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1173					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CCCACAGACGGCCTGCTAGGG	0.652000													62	146					0	0	1	0	0
DMWD	1762	broad.mit.edu	37	19	46288929	46288929	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:46288929G>A	ENST00000270223.6	-	3	1870	c.1825C>T	c.(1825-1827)Ctc>Ttc	p.L609F	DMWD_ENST00000377735.3_Missense_Mutation_p.L609F|AC011530.4_ENST00000593999.1_Silent_p.S101S	NM_004943.1	NP_004934.1	Q09019	DMWD_HUMAN	dystrophia myotonica, WD repeat containing	609					meiosis					central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		AGGAACAGGAGGACTGTGAGC	0.682000													22	29					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861777	52861777	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr4:52861777G>A	ENST00000343457.3	-	4	1417	c.1411C>T	c.(1411-1413)Cct>Tct	p.P471S		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	471						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						GTTCTATCAGGAATTACGGTG	0.567000													60	71					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862902	10862902	+	RNA	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr21:10862902G>A	ENST00000559480.1	+	0	198																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						GGCTTGAGTGGATGGGATTGG	0.552000													89	233					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	12757	12757	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrM:12757T>C	ENST00000361567.2	+	1	421	c.421T>C	c.(421-423)Ttc>Ctc	p.F141L				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	141					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	TATTCCAACTGTTCATCGGCT	0.403000													30	301					0	0	1	0	0
CCDC15	80071	broad.mit.edu	37	11	124845094	124845094	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr11:124845094C>T	ENST00000529051.1	+	5	878	c.619C>T	c.(619-621)Ctt>Ttt	p.L207F	CCDC15_ENST00000344762.5_Missense_Mutation_p.L207F			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	207						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		GAAAAGCTTTCTTACCAGAGA	0.318000													12	4					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117282567	117282567	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:117282567G>T	ENST00000003084.6	+	23	3925	c.3793G>T	c.(3793-3795)Gga>Tga	p.G1265*	AC000111.6_ENST00000456270.1_RNA|CFTR_ENST00000454343.1_Nonsense_Mutation_p.G1204*	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	1265	ABC transporter 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GAACACTGAAGGAGAAATCCA	0.443000									Cystic Fibrosis				25	100					3.28513e-13	3.36705e-13	1	1	0
SMTNL1	219537	broad.mit.edu	37	11	57313487	57313487	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr11:57313487G>T	ENST00000457912.1	+	5	1105	c.1105G>T	c.(1105-1107)Gcc>Tcc	p.A369S	SMTNL1_ENST00000527972.1_Missense_Mutation_p.A351S|SMTNL1_ENST00000399154.2_Missense_Mutation_p.A314S			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	351										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						GAACCGCAAAGCCATCGTGGA	0.667000													13	14					7.93312e-07	8.07058e-07	1	1	0
DPCR1	135656	broad.mit.edu	37	6	30920765	30920765	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:30920765G>A	ENST00000462446.1	+	3	4081	c.4053G>A	c.(4051-4053)cgG>cgA	p.R1351R	DPCR1_ENST00000304311.2_Silent_p.R193R|HCG21_ENST00000419481.1_RNA			Q3MIW9	DPCR1_HUMAN	diffuse panbronchiolitis critical region 1	475						integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)	10						ATATGATGCGGACACGCCGCA	0.498000													20	27					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215877	140215877	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr5:140215877C>T	ENST00000525929.1	+	1	1909	c.1909C>T	c.(1909-1911)Cta>Tta	p.L637L	PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000378125.3_Silent_p.L637L|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACACGAGCCCTAGATGAGAC	0.652000													64	22					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27761265	27761265	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:27761265G>A	ENST00000261588.4	+	16	3003	c.2984G>A	c.(2983-2985)gGa>gAa	p.G995E		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	995										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GGCCTCAACGGAATAGAAATA	0.483000													14	32					0	0	1	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24964293	24964293	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:24964293G>A	ENST00000289968.6	-	11	992	c.923C>T	c.(922-924)tCt>tTt	p.S308F	ARHGAP17_ENST00000303665.5_Missense_Mutation_p.S308F|ARHGAP17_ENST00000441763.2_3'UTR	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	308	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		ATCCAGGTGAGAAGTAGAACA	0.498000													64	76					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90002152	90002152	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr5:90002152G>A	ENST00000405460.2	+	38	8767	c.8671G>A	c.(8671-8673)Ggc>Agc	p.G2891S		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2891	Calx-beta 20.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCCTATCATTGGCTTTCTGAT	0.393000													15	22					0	0	1	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18809176	18809176	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:18809176G>A	ENST00000400664.1	+	1	1753	c.1701G>A	c.(1699-1701)ggG>ggA	p.G567G		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	567						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CGCTCACGGGGATCTGGAGCG	0.662000													20	25					0	0	1	0	0
IQCF3	401067	broad.mit.edu	37	3	51864784	51864784	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:51864784G>C	ENST00000456080.1	+	8	1597	c.432G>C	c.(430-432)caG>caC	p.Q144H	IQCF3_ENST00000444293.1_3'UTR|IQCF3_ENST00000462079.1_3'UTR|IQCF3_ENST00000446775.1_Missense_Mutation_p.Q144H|IQCF3_ENST00000440739.2_Missense_Mutation_p.Q144H|IQCF3_ENST00000437810.2_Missense_Mutation_p.Q144H			P0C7M6	IQCF3_HUMAN	IQ motif containing F3	144										endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CTTCAAAGCAGCCAGAGTTCC	0.483000													27	55					0	0	1	0	0
RP11-467H10.2	0	broad.mit.edu	37	7	76681191	76681191	+	RNA	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:76681191G>A	ENST00000459742.1	+	0	58																											CCCTGGGTCCGGTGTTCTGGA	0.468000													25	9					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27721647	27721647	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:27721647C>T	ENST00000264717.2	+	5	474	c.411C>T	c.(409-411)ctC>ctT	p.L137L	GCKR_ENST00000424318.2_5'UTR	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	137	SIS 1.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					ACACCTACCTCATTGCAGGTG	0.403000													39	35					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43777999	43777999	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:43777999G>A	ENST00000372476.3	+	12	1733	c.1654G>A	c.(1654-1656)Gag>Aag	p.E552K	TIE1_ENST00000433781.2_Missense_Mutation_p.E197K	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	552	Fibronectin type-III 2.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCCGTGGTTGGAGGGCTGGCA	0.627000													50	52					0	0	1	0	0
ORC1	4998	broad.mit.edu	37	1	52838931	52838931	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:52838931G>A	ENST00000371568.3	-	17	2726	c.2508C>T	c.(2506-2508)ccC>ccT	p.P836P	ORC1_ENST00000371566.1_Silent_p.P836P	NM_001190818.1|NM_001190819.1|NM_004153.3	NP_001177747.1|NP_001177748.1|NP_004144.2	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	836	Necessary and sufficient for ORC complex assembly.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CGTTCCTGCTGGGCTCCACAA	0.572000													62	92					0	0	1	0	0
GC	2638	broad.mit.edu	37	4	72618250	72618250	+	Silent	SNP	A	A	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr4:72618250A>T	ENST00000273951.8	-	11	1723	c.1380T>A	c.(1378-1380)ctT>ctA	p.L460L	GC_ENST00000513476.1_Silent_p.L460L|GC_ENST00000503472.1_5'UTR|GC_ENST00000504199.1_Silent_p.L479L	NM_000583.3|NM_001204306.1	NP_000574.2|NP_001191235.1	P02774	VTDB_HUMAN	group-specific component (vitamin D binding protein)	460	Albumin 3.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	45		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	AATCACAGTAAAGAGGAGGTG	0.428000													34	56					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23233360	23233360	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:23233360C>T	ENST00000400191.3	+	11	2064	c.2046C>T	c.(2044-2046)gtC>gtT	p.V682V	EPHB2_ENST00000374630.3_Silent_p.V682V|EPHB2_ENST00000374632.3_Silent_p.V683V|EPHB2_ENST00000374627.1_Silent_p.V677V	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	682	Protein kinase.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		ATCCCAACGTCATCCACCTGG	0.582000													39	45					0	0	1	0	0
IZUMO1	284359	broad.mit.edu	37	19	49247794	49247794	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:49247794C>T	ENST00000332955.2	-	4	860	c.313G>A	c.(313-315)Gat>Aat	p.D105N		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	105					fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		ACGAAGAGATCGCCTGGGAAG	0.498000													35	38					0	0	1	0	0
EPHX2	2053	broad.mit.edu	37	8	27401990	27401990	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr8:27401990A>T	ENST00000521400.1	+	19	2049	c.1619A>T	c.(1618-1620)aAg>aTg	p.K540M	EPHX2_ENST00000380476.3_Missense_Mutation_p.K487M|EPHX2_ENST00000521780.1_Missense_Mutation_p.K474M|EPHX2_ENST00000517536.1_Missense_Mutation_p.K357M|EPHX2_ENST00000518379.1_Missense_Mutation_p.K508M	NM_001979.5	NP_001970.2	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	540	Epoxide hydrolase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	27		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	ATCCTCATTAAGTGGCTGGAT	0.537000													72	99					0	0	1	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													6	130					0	0	1	0	0
R3HDM4	91300	broad.mit.edu	37	19	900089	900089	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:900089G>A	ENST00000361574.5	-	5	606	c.533C>T	c.(532-534)gCc>gTc	p.A178V	R3HDM4_ENST00000587975.1_Missense_Mutation_p.A157V	NM_138774.3	NP_620129.2	Q96D70	CS022_HUMAN	R3H domain containing 4	178	Arg-rich.					nucleus	nucleic acid binding										CTTGAGGACGGCTCGCAGACG	0.642000													30	56					0	0	1	0	0
OR7G2	390882	broad.mit.edu	37	19	9213734	9213734	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:9213734G>A	ENST00000305456.2	-	1	248	c.249C>T	c.(247-249)ttC>ttT	p.F83F		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						GATTGGAGAGGAAGAAGTACA	0.502000													53	65					0	0	1	0	0
CCDC64B	146439	broad.mit.edu	37	16	3085470	3085470	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:3085470G>A	ENST00000572449.1	-	2	90	c.28C>T	c.(28-30)Ccg>Tcg	p.P10S	RP11-473M20.5_ENST00000382225.3_RNA|CCDC64B_ENST00000389347.4_Missense_Mutation_p.P10S			A1A5D9	BICR2_HUMAN	coiled-coil domain containing 64B	10										breast(1)|endometrium(2)|large_intestine(1)	4						GGCCCGGACGGGAAGCTGGGC	0.687000													23	32					0	0	1	0	0
LIPG	9388	broad.mit.edu	37	18	47095874	47095874	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr18:47095874G>A	ENST00000261292.4	+	4	805	c.527G>A	c.(526-528)gGg>gAg	p.G176E	LIPG_ENST00000580036.1_Missense_Mutation_p.G176E|LIPG_ENST00000427224.2_Missense_Mutation_p.G176E|LIPG_ENST00000577628.1_Missense_Mutation_p.G212E	NM_006033.2	NP_006024.1	Q9Y5X9	LIPE_HUMAN	lipase, endothelial	176					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(2)	18						CACGTGGCCGGGTATGCAGGC	0.542000													25	23					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2596821	2596821	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr20:2596821G>A	ENST00000358864.1	+	15	1926	c.1911G>A	c.(1909-1911)ctG>ctA	p.L637L	TMC2_ENST00000496948.1_3'UTR	NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	637						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						GAAATGTGCTGGGTTTGATCT	0.433000													38	50					0	0	1	0	0
PGAM4	441531	broad.mit.edu	37	X	77224407	77224407	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:77224407T>C	ENST00000458128.1	-	1	728	c.729A>G	c.(727-729)atA>atG	p.I243M	ATP7A_ENST00000343533.5_Intron|ATP7A_ENST00000341514.6_Intron|ATP7A_ENST00000350425.4_Intron	NM_001029891.2	NP_001025062.1	Q8N0Y7	PGAM4_HUMAN	phosphoglycerate mutase family member 4	243					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity			endometrium(2)|lung(4)	6						CCACAGCTTCTATGGCTTTGC	0.567000													4	147					0	0	1	0	0
PRMT7	54496	broad.mit.edu	37	16	68373720	68373720	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:68373720C>T	ENST00000339507.5	+	9	1606	c.776C>T	c.(775-777)tCa>tTa	p.S259L	PRMT7_ENST00000564441.1_3'UTR|PRMT7_ENST00000449359.3_Missense_Mutation_p.S209L|PRMT7_ENST00000441236.1_Missense_Mutation_p.S209L|PRMT7_ENST00000348497.4_Missense_Mutation_p.S185L			Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	259					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(10)|pancreas(1)|urinary_tract(1)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		GTCAGTAGCTCAGCAGCCTGC	0.473000													64	95					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													3	76					0	0	1	0	0
IL17RD	54756	broad.mit.edu	37	3	57154294	57154294	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:57154294G>A	ENST00000296318.7	-	2	262	c.174C>T	c.(172-174)ttC>ttT	p.F58F	IL17RD_ENST00000320057.5_5'UTR|IL17RD_ENST00000463523.1_5'UTR|IL17RD_ENST00000427856.2_Silent_p.F34F|IL17RD_ENST00000479825.1_5'UTR	NM_017563.3	NP_060033.3	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D	58						Golgi membrane|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		TGTCATATTTGAAGGTGATGT	0.453000													13	23					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146818211	146818211	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:146818211T>C	ENST00000361727.3	+	6	1411	c.895T>C	c.(895-897)Ttc>Ctc	p.F299L		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	299	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CATGCAGCACTTCCGTACCAA	0.488000										HNSCC(39;0.1)			40	66					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51919939	51919939	+	Silent	SNP	G	G	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:51919939G>C	ENST00000353836.5	-	3	908	c.687C>G	c.(685-687)acC>acG	p.T229T	SIGLEC10_ENST00000432469.2_Silent_p.T146T|CTD-2616J11.2_ENST00000532688.1_RNA|SIGLEC10_ENST00000356298.5_Silent_p.T229T|SIGLEC10_ENST00000339313.5_Silent_p.T229T|SIGLEC10_ENST00000442846.3_Silent_p.T171T|SIGLEC10_ENST00000441969.3_Silent_p.T171T|SIGLEC10_ENST00000525998.1_Silent_p.T229T|SIGLEC10_ENST00000439889.2_Silent_p.T171T|SIGLEC10_ENST00000436984.2_Silent_p.T181T	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	229	Ig-like C2-type 1.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GGAGTCGGACGGTCCTCTGTG	0.647000													25	33					0	0	1	0	0
EXOSC10	5394	broad.mit.edu	37	1	11151617	11151617	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:11151617T>A	ENST00000544779.1	-	4	415	c.410A>T	c.(409-411)aAt>aTt	p.N137I	EXOSC10_ENST00000376936.4_Missense_Mutation_p.N137I|EXOSC10_ENST00000304457.7_Missense_Mutation_p.N137I			Q01780	EXOSX_HUMAN	exosome component 10	137					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|stomach(3)|upper_aerodigestive_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		AGGCTGTTGATTCTTGTTTAC	0.463000													25	48					0	0	1	0	0
NMUR2	56923	broad.mit.edu	37	5	151771977	151771977	+	Silent	SNP	C	C	T	rs146688418	by1000genomes	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr5:151771977C>T	ENST00000255262.3	-	4	1188	c.1023G>A	c.(1021-1023)gtG>gtA	p.V341V		NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	341					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			AAGAAGAGATCACATTCTGGA	0.522000													59	14					0	0	1	0	0
E2F1	1869	broad.mit.edu	37	20	32264637	32264637	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr20:32264637G>A	ENST00000343380.5	-	7	1354	c.1215C>T	c.(1213-1215)ccC>ccT	p.P405P		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	405	Transactivation.				apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						GGGCCTCGTGGGGTGGGGAAA	0.652000													8	2					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815454	106815454	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr8:106815454G>A	ENST00000407775.2	+	8	3394	c.3144G>A	c.(3142-3144)ctG>ctA	p.L1048L	RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000378472.4_Silent_p.L779L|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000517361.1_Silent_p.L916L|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000522296.1_3'UTR|ZFPM2_ENST00000520492.1_Silent_p.L916L	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	1048					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			ATGGTGGACTGAAACAAGATG	0.488000													19	26					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104174954	104174954	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr10:104174954G>A	ENST00000020673.5	-	4	1316	c.790C>T	c.(790-792)Cca>Tca	p.P264S	PSD_ENST00000406432.1_Missense_Mutation_p.P264S	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	264					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		ACCCCAGGTGGAGATGGGGGG	0.627000													22	48					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41101041	41101041	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr20:41101041C>T	ENST00000373198.3	-	8	1550	c.1315G>A	c.(1315-1317)Gag>Aag	p.E439K	PTPRT_ENST00000373193.3_Missense_Mutation_p.E439K|PTPRT_ENST00000373201.1_Missense_Mutation_p.E439K|PTPRT_ENST00000356100.2_Missense_Mutation_p.E439K|PTPRT_ENST00000373190.1_Missense_Mutation_p.E439K|PTPRT_ENST00000373187.1_Missense_Mutation_p.E439K|PTPRT_ENST00000373184.1_Missense_Mutation_p.E439K	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	439	Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGATGACCTCCTCGGCCTCG	0.622000													49	60					0	0	1	0	0
ZNF81	347344	broad.mit.edu	37	X	47774789	47774789	+	Silent	SNP	T	T	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:47774789T>C	ENST00000376954.1	+	6	1112	c.744T>C	c.(742-744)cgT>cgC	p.R248R	ZNF81_ENST00000338637.7_Silent_p.R248R			P51508	ZNF81_HUMAN	zinc finger protein 81	248						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(1)|lung(1)|skin(1)	4		all_lung(315;0.0973)				TCTGTGAACGTAATCAATGTG	0.393000													56	60					0	0	1	0	0
NBN	4683	broad.mit.edu	37	8	90982699	90982699	+	Silent	SNP	A	A	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr8:90982699A>G	ENST00000265433.3	-	7	943	c.789T>C	c.(787-789)ttT>ttC	p.F263F	NBN_ENST00000409330.1_Silent_p.F181F	NM_002485.4	NP_002476.2	O60934	NBN_HUMAN	nibrin	263					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(11;0.0344)			CCGGAGCCAAAAAGAAATTAT	0.393000								Homologous recombination					44	50					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90002153	90002153	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr5:90002153G>A	ENST00000405460.2	+	38	8768	c.8672G>A	c.(8671-8673)gGc>gAc	p.G2891D		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2891	Calx-beta 20.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCTATCATTGGCTTTCTGATT	0.393000													15	22					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181754944	181754944	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:181754944C>T	ENST00000526775.1	+	42	5883	c.5718C>T	c.(5716-5718)ccC>ccT	p.P1906P	CACNA1E_ENST00000358338.5_Silent_p.P1857P|CACNA1E_ENST00000357570.5_Silent_p.P1876P|CACNA1E_ENST00000367570.1_Silent_p.P1925P|CACNA1E_ENST00000360108.3_Silent_p.P1906P|CACNA1E_ENST00000367573.2_Silent_p.P1925P|CACNA1E_ENST00000367567.4_Silent_p.P1532P	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1925					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AGCAGGACCCCGTTTCAGGCC	0.542000													109	280					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60889897	60889897	+	Silent	SNP	G	G	A	rs117652580	byFrequency	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr20:60889897G>A	ENST00000252999.3	-	60	8220	c.8154C>T	c.(8152-8154)cgC>cgT	p.R2718R		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	2718	Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTCTCGCACGCGGCCAATGC	0.672000													60	219					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	31799634	31799634	+	Silent	SNP	C	C	T	rs146790239		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr5:31799634C>T	ENST00000438447.1	+	2	667	c.279C>T	c.(277-279)ttC>ttT	p.F93F	PDZD2_ENST00000282493.3_Silent_p.F93F			O15018	PDZD2_HUMAN	PDZ domain containing 2	93	PDZ 1.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						TCCCTGTTTTCGGGGACTATG	0.567000													75	87					0	0	1	0	0
SRP68	6730	broad.mit.edu	37	17	74053552	74053552	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:74053552G>A	ENST00000307877.2	-	8	1071	c.910C>T	c.(910-912)Cca>Tca	p.P304S	SRP68_ENST00000539137.1_Missense_Mutation_p.P266S|SRP68_ENST00000355113.5_Missense_Mutation_p.P203S	NM_014230.3	NP_055045.2	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	304					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			NS(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|lung(4)|ovary(2)|prostate(3)	23						ATCTTCACTGGAACCGTTCTC	0.443000													43	64					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62856553	62856553	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:62856553G>A	ENST00000584306.1	-	11	4241	c.3711C>T	c.(3709-3711)ttC>ttT	p.F1237F	LRRC37A3_ENST00000400877.3_Silent_p.F275F|LRRC37A3_ENST00000334962.5_Silent_p.F214F|LRRC37A3_ENST00000339474.5_Silent_p.F355F|LRRC37A3_ENST00000319651.5_Silent_p.F1237F	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1237						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						GCTCTTGGGTGAACGAAGGCT	0.577000													49	70					0	0	1	0	0
KIAA1841	84542	broad.mit.edu	37	2	61304111	61304111	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:61304111C>T	ENST00000402291.1	+	6	729	c.488C>T	c.(487-489)aCt>aTt	p.T163I	KIAA1841_ENST00000453873.1_Missense_Mutation_p.T163I|KIAA1841_ENST00000356719.2_Missense_Mutation_p.T163I|KIAA1841_ENST00000295031.5_Missense_Mutation_p.T163I|KIAA1841_ENST00000482513.1_3'UTR	NM_001129993.1	NP_001123465.1	Q6NSI8	K1841_HUMAN	KIAA1841	163										breast(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	25			Epithelial(17;0.193)			GAAGATTTTACTTGCCCGCGA	0.363000													49	56					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43821986	43821986	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr15:43821986A>G	ENST00000382031.1	+	6	8919	c.8888A>G	c.(8887-8889)aAt>aGt	p.N2963S	MAP1A_ENST00000399453.1_Missense_Mutation_p.N2725S|MAP1A_ENST00000300231.5_Missense_Mutation_p.N2725S			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2725						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GTCAGTGGGAATGACCCTGCC	0.572000													23	34					0	0	1	0	0
CLDN6	9074	broad.mit.edu	37	16	3065465	3065465	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:3065465G>A	ENST00000396925.1	-	3	986	c.558C>T	c.(556-558)ccC>ccT	p.P186P	CLDN6_ENST00000572154.1_Intron|CLDN6_ENST00000328796.4_Silent_p.P186P			P56747	CLD6_HUMAN	claudin 6	186					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	10						ACCCCCCCGAGGGGCAAGTGC	0.652000													25	41					0	0	1	0	0
PHF21A	51317	broad.mit.edu	37	11	45987052	45987052	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr11:45987052G>A	ENST00000257821.4	-	9	1433	c.810C>T	c.(808-810)ttC>ttT	p.F270F	PHF21A_ENST00000323180.6_Silent_p.F270F|PHF21A_ENST00000418153.2_Silent_p.F269F	NM_001101802.1	NP_001095272.1	Q96BD5	PF21A_HUMAN	PHD finger protein 21A	269					blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(10)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	29						TTGTGGGGGTGAACTTGGTCA	0.582000											OREG0020936	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	8					0	0	1	0	0
HSPB8	26353	broad.mit.edu	37	12	119617291	119617291	+	Silent	SNP	C	C	T	rs56046128		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:119617291C>T	ENST00000281938.2	+	1	845	c.174C>T	c.(172-174)tcC>tcT	p.S58S		NM_014365.2	NP_055180.1	Q9UJY1	HSPB8_HUMAN	heat shock 22kDa protein 8	58					cell death|response to heat	cytoplasm|nucleus	identical protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	14	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTCTCTCCTCCGCCTGGCCAG	0.692000													90	99					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49737904	49737904	+	Splice_Site	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:49737904G>A	ENST00000327697.6	+	14	1254		c.e14-1		RNF123_ENST00000432042.1_Splice_Site	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123							cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		TCTTCCCCCAGGACTACGAGG	0.572000													51	73					0	0	1	0	0
EFNB3	1949	broad.mit.edu	37	17	7612675	7612675	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:7612675C>T	ENST00000226091.2	+	5	1201	c.804C>T	c.(802-804)tcC>tcT	p.S268S		NM_001406.3	NP_001397.1	Q15768	EFNB3_HUMAN	ephrin-B3	268					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				GTCCTGGCTCCTTCGGGAGGG	0.716000													14	21					0	0	1	0	0
RHBDD1	84236	broad.mit.edu	37	2	227729454	227729454	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:227729454C>T	ENST00000392062.2	+	4	569	c.45C>T	c.(43-45)ctC>ctT	p.L15L	RHBDD1_ENST00000341329.3_Silent_p.L15L	NM_001167608.1	NP_001161080.1	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	15						integral to membrane	serine-type endopeptidase activity			breast(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		TTATTCTACTCCTTTCTCAAA	0.458000													77	114					0	0	1	0	0
ZNF226	7769	broad.mit.edu	37	19	44679947	44679947	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:44679947C>T	ENST00000590089.1	+	7	899	c.532C>T	c.(532-534)Ctg>Ttg	p.L178L	ZNF226_ENST00000588883.1_3'UTR|ZNF226_ENST00000337433.5_Silent_p.L178L|ZNF226_ENST00000454662.2_Silent_p.L178L			Q9NYT6	ZN226_HUMAN	zinc finger protein 226	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				GAAAACATTCCTGACTGAGTC	0.373000													20	22					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99150236	99150236	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr10:99150236C>T	ENST00000370992.4	-	6	808	c.697G>A	c.(697-699)Gtg>Atg	p.V233M	RRP12_ENST00000536831.1_Missense_Mutation_p.V39M|RRP12_ENST00000315563.6_Intron|RRP12_ENST00000414986.1_Missense_Mutation_p.V172M	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	233						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TGAAGGGTCACGGGGTAGCCC	0.607000													47	40					0	0	1	0	0
PLCD4	84812	broad.mit.edu	37	2	219486275	219486275	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:219486275C>T	ENST00000450993.2	+	5	832	c.493C>T	c.(493-495)Cta>Tta	p.L165L	PLCD4_ENST00000417849.1_Silent_p.L165L|PLCD4_ENST00000432688.1_Silent_p.L165L	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	165	EF-hand 1.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GTTATTGCACCTAATGAATGT	0.458000													139	171					0	0	1	0	0
ZNF787	126208	broad.mit.edu	37	19	56599601	56599601	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:56599601C>T	ENST00000270459.3	-	3	1058	c.940G>A	c.(940-942)Gag>Aag	p.E314K		NM_001002836.2	NP_001002836.2	Q6DD87	ZN787_HUMAN	zinc finger protein 787	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|lung(2)|pancreas(1)	5		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0559)		TGGGCCGGCTCCTCGCCCCCC	0.761000													6	12					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57938642	57938642	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:57938642C>T	ENST00000564448.1	-	26	2672	c.2612G>A	c.(2611-2613)gGa>gAa	p.G871E	CNGB1_ENST00000251102.8_Missense_Mutation_p.G877E			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	877					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						CGATACCTGTCCGATCATCAC	0.567000													72	104					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				93	70					0	0	1	0	0
ITGA3	3675	broad.mit.edu	37	17	48154808	48154808	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:48154808G>A	ENST00000320031.8	+	16	2466	c.2136G>A	c.(2134-2136)caG>caA	p.Q712Q	ITGA3_ENST00000007722.7_Silent_p.Q712Q	NM_002204.2|NM_005501.2	NP_002195.1|NP_005492.1	P26006	ITA3_HUMAN	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	712					blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	31						AACGGAACCAGAGGGTGAGCA	0.607000													51	71					0	0	1	0	0
G2E3	55632	broad.mit.edu	37	14	31071212	31071212	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr14:31071212C>A	ENST00000206595.6	+	10	1039	c.885C>A	c.(883-885)ttC>ttA	p.F295L	G2E3_ENST00000544007.1_3'UTR|G2E3_ENST00000553504.1_Missense_Mutation_p.F325L|G2E3_ENST00000438909.2_Missense_Mutation_p.F249L	NM_017769.3	NP_060239.2	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin protein ligase	295					apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						TAGGAGAGTTCCAAAAAGCCA	0.299000													36	32					1.42033e-22	1.47042e-22	1	1	0
GKN1	56287	broad.mit.edu	37	2	69204835	69204835	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:69204835G>T	ENST00000377938.2	+	3	238	c.175G>T	c.(175-177)Gaa>Taa	p.E59*		NM_019617.3	NP_062563.3	Q9NS71	GKN1_HUMAN	gastrokine 1	59					digestion|positive regulation of cell division	extracellular region				breast(2)|large_intestine(4)|lung(5)	11						TGTCAACAATGAACACAATGT	0.393000													47	54					7.90463e-13	8.0816e-13	1	1	0
MT-ND5	4540	broad.mit.edu	37	MT	12705	12705	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrM:12705C>T	ENST00000361567.2	+	1	369	c.369C>T	c.(367-369)atC>atT	p.I123I				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	123					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	TATCTACTCATTTTCCTAATT	0.373000													7	335					0	0	1	0	0
C1QL2	165257	broad.mit.edu	37	2	119914397	119914397	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:119914397A>T	ENST00000272520.3	-	2	1464	c.845T>A	c.(844-846)tTt>tAt	p.F282Y		NM_182528.3	NP_872334.2	Q7Z5L3	C1QL2_HUMAN	complement component 1, q subcomponent-like 2	282	C1q.					collagen				NS(1)|endometrium(1)|large_intestine(3)|pancreas(1)|prostate(1)	7						GTACAGAAGAAAGCCCGAGAA	0.637000										HNSCC(49;0.14)			61	67					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118199219	118199219	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:118199219G>A	ENST00000425217.1	-	4	550	c.496C>T	c.(496-498)Ctc>Ttc	p.L166F	KSR2_ENST00000339824.5_Missense_Mutation_p.L195F	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	195					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTCTGGGAGAGATGGGTGCGG	0.642000													32	42					0	0	1	0	0
C10orf120	399814	broad.mit.edu	37	10	124457907	124457907	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr10:124457907G>A	ENST00000329446.4	-	3	381	c.350C>T	c.(349-351)cCg>cTg	p.P117L		NM_001010912.1	NP_001010912.1	Q5SQS8	CJ120_HUMAN	chromosome 10 open reading frame 120	117								p.P117Q(1)		endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|skin(2)|stomach(1)|urinary_tract(1)	21		all_neural(114;0.169)|Glioma(114;0.222)				TTTGTAGTCCGGAGACAGCAA	0.448000													191	161					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71740914	71740914	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:71740914C>T	ENST00000258104.3	+	6	803	c.526C>T	c.(526-528)Caa>Taa	p.Q176*	DYSF_ENST00000409651.1_Nonsense_Mutation_p.Q208*|DYSF_ENST00000410020.3_Nonsense_Mutation_p.Q208*|DYSF_ENST00000409762.1_Nonsense_Mutation_p.Q207*|DYSF_ENST00000409582.3_Nonsense_Mutation_p.Q207*|DYSF_ENST00000409366.1_Nonsense_Mutation_p.Q177*|DYSF_ENST00000394120.2_Nonsense_Mutation_p.Q177*|DYSF_ENST00000409744.1_Nonsense_Mutation_p.Q177*|DYSF_ENST00000429174.2_Nonsense_Mutation_p.Q176*|DYSF_ENST00000413539.2_Nonsense_Mutation_p.Q207*|DYSF_ENST00000410041.1_Nonsense_Mutation_p.Q208*	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	176						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						ATTCCTGGATCAAAGCGGAGG	0.597000													28	33					0	0	1	0	0
OCRL	4952	broad.mit.edu	37	X	128724183	128724183	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:128724183C>T	ENST00000371113.4	+	24	2807	c.2642C>T	c.(2641-2643)cCa>cTa	p.P881L	OCRL_ENST00000357121.5_Missense_Mutation_p.P873L	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	881	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						AGACAGACTCCAAGTGACCGC	0.488000													149	211					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126240964	126240964	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr4:126240964G>A	ENST00000394329.3	+	1	3411	c.3398G>A	c.(3397-3399)gGa>gAa	p.G1133E		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1133	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GGGCCAAATGGAGAAGTAAGG	0.413000													78	94					0	0	1	0	0
ZNF10	7556	broad.mit.edu	37	12	133732292	133732292	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:133732292C>A	ENST00000248211.6	+	5	682	c.460C>A	c.(460-462)Caa>Aaa	p.Q154K	CTD-2140B24.4_ENST00000540096.2_Intron|ZNF10_ENST00000426665.2_Missense_Mutation_p.Q154K|ZNF10_ENST00000402932.2_Intron|ZNF268_ENST00000416488.1_Intron	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	154				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding	p.Q154K(1)		breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GGCATTCACCCAAAAGAAAGT	0.413000													14	94					2.31682e-05	2.35115e-05	1	1	0
FCGBP	8857	broad.mit.edu	37	19	40433553	40433553	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:40433553A>G	ENST00000221347.6	-	2	723	c.716T>C	c.(715-717)gTt>gCt	p.V239A		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	239	IgGFc-binding.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CAGCTGCTCAACCACATGGTT	0.587000													35	55					0	0	1	0	0
ASIC4	55515	broad.mit.edu	37	2	220399924	220399924	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:220399924C>T	ENST00000358078.4	+	6	1502	c.1488C>T	c.(1486-1488)tgC>tgT	p.C496C	ASIC4_ENST00000347842.3_Silent_p.C477C			Q96FT7	ACCN4_HUMAN	acid-sensing (proton-gated) ion channel family member 4	477						integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity										AGGGCCCGTGCTTCTGCCCCA	0.627000													36	53					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61512921	61512921	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr20:61512921G>A	ENST00000266070.4	-	16	4712	c.4387C>T	c.(4387-4389)Ccg>Tcg	p.P1463S	DIDO1_ENST00000395343.1_Missense_Mutation_p.P1463S	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1463					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CCGGCCACCGGCTCGGCAGGC	0.577000													181	81					0	0	1	0	0
LOC645166	645166	broad.mit.edu	37	1	148932838	148932838	+	RNA	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:148932838G>A	ENST00000539543.1	+	0	94					NR_027355.1																						GAGCTGCCCAGCATGGCTGCA	0.607000													40	352					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21229268	21229268	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:21229268G>A	ENST00000233242.1	-	26	10599	c.10472C>T	c.(10471-10473)tCc>tTc	p.S3491F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3491	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGACTCAATGGAAAAGTAAGA	0.413000													62	75					0	0	1	0	0
RNF34	80196	broad.mit.edu	37	12	121858571	121858571	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:121858571C>T	ENST00000361234.5	+	5	1090	c.918C>T	c.(916-918)aaC>aaT	p.N306N	RNF34_ENST00000392464.2_Silent_p.N306N|RNF34_ENST00000555076.1_Intron|RNF34_ENST00000392465.3_Silent_p.N307N	NM_025126.3	NP_079402.2	Q969K3	RNF34_HUMAN	ring finger protein 34, E3 ubiquitin protein ligase	306					apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding			breast(1)|large_intestine(1)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)		ATGAAGAAAACCAAAAGTCCT	0.333000													42	63					0	0	1	0	0
SERPINI1	5274	broad.mit.edu	37	3	167507022	167507022	+	Missense_Mutation	SNP	C	C	T	rs61735306	byFrequency	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:167507022C>T	ENST00000295777.5	+	2	537	c.106C>T	c.(106-108)Cgt>Tgt	p.R36C	SERPINI1_ENST00000446050.2_Missense_Mutation_p.R36C	NM_005025.4	NP_005016.1	Q99574	NEUS_HUMAN	serpin peptidase inhibitor, clade I (neuroserpin), member 1	36					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(7)|skin(2)	20						TATGTATAATCGTCTTAGAGC	0.453000													53	59					0	0	1	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18809175	18809175	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:18809175G>A	ENST00000400664.1	+	1	1752	c.1700G>A	c.(1699-1701)gGg>gAg	p.G567E		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	567						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCGCTCACGGGGATCTGGAGC	0.667000													21	25					0	0	1	0	0
CYP2D7	1564	broad.mit.edu	37	22	42538870	42538870	+	RNA	SNP	A	A	C	rs2982057	by1000genomes	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr22:42538870A>C	ENST00000358097.4	-	0	449				CYP2D7P1_ENST00000433992.1_RNA|CYP2D7P1_ENST00000424775.1_RNA																endometrium(1)	1						CCATAGCGCGACAGGAACACC	0.687000													5	30					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423973	56423973	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:56423973C>T	ENST00000588751.1	-	5	1234	c.1210G>A	c.(1210-1212)Gaa>Aaa	p.E404K	NLRP13_ENST00000342929.3_Missense_Mutation_p.E404K			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	404	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TTCTCAACTTCACTTGAGTCA	0.443000													66	66					0	0	1	0	0
ZNF41	7592	broad.mit.edu	37	X	47307904	47307904	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:47307904C>T	ENST00000377065.4	-	5	1904	c.1265G>A	c.(1264-1266)aGa>aAa	p.R422K	ZNF41_ENST00000313116.7_Missense_Mutation_p.R422K|ZNF41_ENST00000397050.2_Missense_Mutation_p.R432K	NM_153380.2	NP_700359.1	P51814	ZNF41_HUMAN	zinc finger protein 41	464						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|upper_aerodigestive_tract(2)	24		all_lung(315;0.000129)				TGCTGATTTTCTTGTGAAAGC	0.448000													91	143					0	0	1	0	0
PPP1R26	9858	broad.mit.edu	37	9	138376659	138376659	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr9:138376659C>T	ENST00000356818.2	+	4	852	c.303C>T	c.(301-303)ctC>ctT	p.L101L	PPP1R26_ENST00000602993.1_Intron|PPP1R26_ENST00000401470.3_Silent_p.L101L|PPP1R26_ENST00000605660.1_Silent_p.L101L|PPP1R26_ENST00000605286.1_Silent_p.L101L|PPP1R26_ENST00000604351.1_Silent_p.L101L	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	101						nucleolus	protein binding										TCTGTGGTCTCGTTGCTGACT	0.617000													86	14					0	0	1	0	0
VPS51	738	broad.mit.edu	37	11	64876943	64876943	+	Silent	SNP	C	C	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr11:64876943C>A	ENST00000279281.3	+	6	1727	c.1635C>A	c.(1633-1635)ctC>ctA	p.L545L	VPS51_ENST00000527646.1_3'UTR	NM_013265.2	NP_037397.2			vacuolar protein sorting 51 homolog (S. cerevisiae)																		TCCTCACTCTCACTGATGAAC	0.612000													35	36					6.97489e-18	7.20271e-18	1	1	0
HAP1	9001	broad.mit.edu	37	17	39881252	39881252	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:39881252G>A	ENST00000393939.2	-	10	1495	c.1486C>T	c.(1486-1488)Ccg>Tcg	p.P496S	HAP1_ENST00000347901.4_Missense_Mutation_p.P521S|JUP_ENST00000540235.1_Intron|HAP1_ENST00000341193.5_Missense_Mutation_p.P504S|HAP1_ENST00000310778.5_Missense_Mutation_p.P573S			P54257	HAP1_HUMAN	huntingtin-associated protein 1	556	Glu-rich.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(4)|skin(1)	21		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			TCCTCAGCCGGCACCTTCTTG	0.627000													6	516					0	0	1	0	0
KRTAP17-1	83902	broad.mit.edu	37	17	39471682	39471682	+	Missense_Mutation	SNP	C	C	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:39471682C>G	ENST00000334202.3	-	1	265	c.221G>C	c.(220-222)gGc>gCc	p.G74A		NM_031964.1	NP_114170.1	Q9BYP8	KR171_HUMAN	keratin associated protein 17-1	74						intermediate filament				haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)	2		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			tccacagcagccacccccgca	0.657000													11	19					0	0	1	0	0
CUL9	23113	broad.mit.edu	37	6	43163917	43163917	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:43163917C>T	ENST00000252050.4	+	10	2583	c.2499C>T	c.(2497-2499)gcC>gcT	p.A833A	CUL9_ENST00000354495.3_Silent_p.A723A|CUL9_ENST00000372647.2_Silent_p.A833A	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	833					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						AGATCTTCGCCAGCATCGACT	0.572000													63	81					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	12684	12684	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrM:12684G>A	ENST00000361567.2	+	1	348	c.348G>A	c.(346-348)caG>caA	p.Q116Q				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	116					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	AACATTAATCAGTTCTTCAAA	0.368000													6	327					0	0	1	0	0
HYI	81888	broad.mit.edu	37	1	43916981	43916981	+	Splice_Site	SNP	T	T	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:43916981T>A	ENST00000372425.4	-	8	957	c.760_splice	c.e8-1	p.G254_splice	HYI_ENST00000372426.1_Splice_Site_p.G206_splice|HYI_ENST00000372432.1_Splice_Site_p.*248_splice|SZT2_ENST00000562955.1_3'UTR|SZT2_ENST00000372442.1_3'UTR|HYI_ENST00000372434.1_Splice_Site_p.G279_splice|HYI_ENST00000583037.1_Splice_Site_p.G181_splice			Q5T013	HYI_HUMAN	hydroxypyruvate isomerase (putative)	254							hydroxypyruvate isomerase activity			large_intestine(1)|lung(2)|ovary(1)|urinary_tract(2)	6	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTACTGTGTCTCCTGCAGGGA	0.662000													74	113					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31414954	31414954	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:31414954T>A	ENST00000389202.2	+	7	741	c.692T>A	c.(691-693)aTc>aAc	p.I231N	RP11-120K18.2_ENST00000567545.1_RNA	NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	231	VWFA.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GCCACGGGCATCCTGACAGTG	0.612000													14	97					0	0	1	0	0
OR14C36	127066	broad.mit.edu	37	1	248512918	248512918	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:248512918C>T	ENST00000317861.1	+	1	842	c.842C>T	c.(841-843)cCc>cTc	p.P281L		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						ATAATGCCTCCCCTCTTTAAC	0.398000													52	150					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118969934	118969934	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr5:118969934C>T	ENST00000515256.1	+	3	663	c.491C>T	c.(490-492)tCt>tTt	p.S164F				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	164						intracellular	zinc ion binding	p.S164F(2)		breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						GTGACCCTTTCTGAGGTTGTG	0.517000													37	60					0	0	1	0	0
TRMT11	60487	broad.mit.edu	37	6	126359916	126359916	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:126359916C>T	ENST00000334379.5	+	13	1447	c.1326C>T	c.(1324-1326)ttC>ttT	p.F442F	TRMT11_ENST00000368332.3_Silent_p.F437F	NM_001031712.2	NP_001026882.2	Q7Z4G4	TRM11_HUMAN	tRNA methyltransferase 11 homolog (S. cerevisiae)	442					tRNA processing		methyltransferase activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				GBM - Glioblastoma multiforme(226;0.0356)		ATAATTCCTTCCGTGAGAAAT	0.333000													66	11					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534372	92534372	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr11:92534372G>A	ENST00000298047.6	+	9	8210	c.8193G>A	c.(8191-8193)agG>agA	p.R2731R	FAT3_ENST00000409404.2_Silent_p.R2731R|FAT3_ENST00000525166.1_Silent_p.R2581R			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2731	Cadherin 25.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACACCCTGAGGATTTTGCCCA	0.473000										TCGA Ovarian(4;0.039)			19	71					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39228673	39228673	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:39228673G>A	ENST00000340369.3	-	2	2492	c.2264C>T	c.(2263-2265)cCc>cTc	p.P755L	XIRP1_ENST00000396251.1_Missense_Mutation_p.P755L|XIRP1_ENST00000421646.1_Intron	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	755							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGGGCTCATGGGCTGCTCTTC	0.597000													38	38					0	0	1	0	0
PSMD12	5718	broad.mit.edu	37	17	65341905	65341905	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:65341905G>A	ENST00000356126.3	-	8	971	c.864C>T	c.(862-864)caC>caT	p.H288H	PSMD12_ENST00000357146.4_Silent_p.H268H	NM_002816.3	NP_002807.1	O00232	PSD12_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	288	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding			breast(1)|large_intestine(4)|lung(6)|pancreas(1)|urinary_tract(1)	13	all_cancers(12;2.38e-11)|all_epithelial(3;8.27e-13)					CACTTATTCGGTGAACCAAAT	0.353000													35	45					0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26925653	26925653	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:26925653C>T	ENST00000321765.5	-	2	384	c.51_splice	c.e2-1	p.G18_splice		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	18					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					GATGGTTTTCCCTGAGAAAGA	0.562000													30	37					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18393610	18393610	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:18393610C>T	ENST00000338745.6	-	10	3387	c.1653G>A	c.(1651-1653)atG>atA	p.M551I	SATB1_ENST00000454909.2_Missense_Mutation_p.M551I|SATB1_ENST00000417717.2_Missense_Mutation_p.M551I|TBC1D5_ENST00000414318.2_Intron	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	551					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						ACCTTCGGATCATGGAGAGGT	0.522000													52	64					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41447102	41447102	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr21:41447102C>T	ENST00000400454.1	-	27	5227	c.4750G>A	c.(4750-4752)Gaa>Aaa	p.E1584K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1584					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGCCCTTCTTCGTTTTGGACA	0.527000													34	7					0	0	1	0	0
SCPEP1	59342	broad.mit.edu	37	17	55068477	55068477	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:55068477C>T	ENST00000262288.3	+	6	619	c.564C>T	c.(562-564)acC>acT	p.T188T	SCPEP1_ENST00000571898.1_3'UTR	NM_021626.2	NP_067639.1	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1	188					proteolysis	extracellular region	serine-type carboxypeptidase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	14	Breast(9;2.86e-08)					AGCGAGGGACCATCAAGTGCA	0.527000													99	149					0	0	1	0	0
IZUMO2	126123	broad.mit.edu	37	19	50662765	50662765	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:50662765G>A	ENST00000293405.3	-	3	380	c.380C>T	c.(379-381)tCa>tTa	p.S127L		NM_152358.2	NP_689571.2	Q6UXV1	IZUM2_HUMAN	IZUMO family member 2	127						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						TAATTCATATGAAATTAAAAC	0.458000													23	37					0	0	1	0	0
KDM8	79831	broad.mit.edu	37	16	27224963	27224963	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:27224963C>T	ENST00000286096.4	+	3	729	c.556C>T	c.(556-558)Cgg>Tgg	p.R186W	KDM8_ENST00000441782.2_Missense_Mutation_p.R224W|KDM8_ENST00000380948.2_Intron|KDM8_ENST00000568965.1_Intron|CTD-3203P2.1_ENST00000567108.1_RNA	NM_024773.2	NP_079049.2	Q8N371	KDM8_HUMAN	lysine (K)-specific demethylase 8	186					G2/M transition of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|histone demethylase activity (H3-K36 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen										AACAGTCCCCCGGCTGCACCG	0.517000													51	83					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167250699	167250699	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:167250699G>A	ENST00000308378.3	-	8	1270	c.965C>T	c.(964-966)cCt>cTt	p.P322L	WDR49_ENST00000479765.1_Intron|WDR49_ENST00000453925.2_Missense_Mutation_p.P386L|WDR49_ENST00000476376.1_Missense_Mutation_p.P147L	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	322										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CTGGTAATCAGGGTGAAGAAC	0.393000													36	44					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19349160	19349160	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:19349160C>T	ENST00000252575.5	+	11	3392	c.3349C>T	c.(3349-3351)Cgc>Tgc	p.R1117C	NCAN_ENST00000538881.1_Missense_Mutation_p.R568C	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1117	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GAAGGACTGCCGCCGCCGCTC	0.642000													52	62					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149439322	149439322	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr5:149439322C>T	ENST00000286301.3	-	15	2364	c.2073G>A	c.(2071-2073)caG>caA	p.Q691Q		NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	691	Protein kinase.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CCTCGGGGTCCTGGCCGGGGC	0.577000													67	13					0	0	1	0	0
KRT16P6	353194	broad.mit.edu	37	17	16722266	16722266	+	RNA	SNP	C	C	T	rs2656363	by1000genomes	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:16722266C>T	ENST00000417510.1	-	0	1464																											TGGGCATCCTCGCCCTCCAGC	0.592000													26	88					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67801048	67801048	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr13:67801048C>T	ENST00000544246.1	-	2	2216	c.1525G>A	c.(1525-1527)Gga>Aga	p.G509R	PCDH9_ENST00000377861.3_Missense_Mutation_p.G509R|PCDH9_ENST00000456367.1_Missense_Mutation_p.G509R|PCDH9_ENST00000328454.5_Missense_Mutation_p.G509R|PCDH9_ENST00000377865.2_Missense_Mutation_p.G509R	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	509	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GCATTCGGTCCAAGCTGATAA	0.413000													39	38					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81675116	81675116	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:81675116G>T	ENST00000550584.2	-	26	3427	c.3132C>A	c.(3130-3132)tgC>tgA	p.C1044*	PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000333447.7_Nonsense_Mutation_p.C1029*|PPFIA2_ENST00000549396.1_Nonsense_Mutation_p.C1044*|PPFIA2_ENST00000548586.1_Nonsense_Mutation_p.C1038*|PPFIA2_ENST00000443686.3_Nonsense_Mutation_p.C939*|PPFIA2_ENST00000541570.2_Nonsense_Mutation_p.C580*|PPFIA2_ENST00000552948.1_Nonsense_Mutation_p.C1023*|PPFIA2_ENST00000407050.4_Nonsense_Mutation_p.C943*|RP11-121G22.3_ENST00000549161.1_lincRNA|PPFIA2_ENST00000550359.2_Nonsense_Mutation_p.C891*|PPFIA2_ENST00000541017.1_Nonsense_Mutation_p.C230*|PPFIA2_ENST00000549325.1_Nonsense_Mutation_p.C1029*	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	943										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						CATCTACCAAGCATTCCATAA	0.388000													39	46					1.03484e-13	1.06329e-13	1	1	0
MAGT1	84061	broad.mit.edu	37	X	77112265	77112265	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:77112265G>A	ENST00000358075.6	-	5	819	c.733C>T	c.(733-735)Ctc>Ttc	p.L245F		NM_032121.5	NP_115497.4	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	213					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				cervix(1)|kidney(2)|large_intestine(3)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	17						TTATTAAAGAGAAATTCCATA	0.343000													74	113					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62197525	62197525	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr20:62197525G>A	ENST00000467148.1	-	8	2719	c.2650C>T	c.(2650-2652)Cct>Tct	p.P884S	HELZ2_ENST00000427522.2_Missense_Mutation_p.P315S	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		AGTGCCCCAGGGCTGAGCAGG	0.697000													4	19					0	0	1	0	0
MSN	4478	broad.mit.edu	37	X	64953082	64953082	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:64953082C>T	ENST00000360270.5	+	7	907	c.735C>T	c.(733-735)atC>atT	p.I245I		NM_002444.2	NP_002435.1	P26038	MOES_HUMAN	moesin	245	FERM.				leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	breast(4)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	43						GGAGTGAAATCAGGAACATCT	0.448000			T	ALK	ALCL								59	83					0	0	1	0	0
SLC25A35	399512	broad.mit.edu	37	17	8194751	8194751	+	Nonsense_Mutation	SNP	A	A	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:8194751A>T	ENST00000380067.2	-	3	538	c.494T>A	c.(493-495)tTa>tAa	p.L165*	SLC25A35_ENST00000577745.1_Nonsense_Mutation_p.L165*|SLC25A35_ENST00000396278.1_Nonsense_Mutation_p.L165*|SLC25A35_ENST00000579192.1_Nonsense_Mutation_p.L165*|SLC25A35_ENST00000580340.1_Nonsense_Mutation_p.L165*	NM_201520.1	NP_958928.1	Q3KQZ1	S2535_HUMAN	solute carrier family 25, member 35	165					transport	integral to membrane|mitochondrial inner membrane				breast(2)|large_intestine(2)|lung(2)	6						CCCACGCCATAACCCCACCAG	0.622000													31	39					0	0	1	0	0
TOP3B	8940	broad.mit.edu	37	22	22318363	22318363	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr22:22318363C>T	ENST00000398793.2	-	11	1570	c.1136G>A	c.(1135-1137)cGg>cAg	p.R379Q	TOP3B_ENST00000357179.5_Missense_Mutation_p.R379Q|TOP3B_ENST00000413067.2_Missense_Mutation_p.R108Q	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	379					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		ATGGCCTTTCCGCGGGCGGTT	0.612000													39	96					0	0	1	0	0
WWP1	11059	broad.mit.edu	37	8	87437474	87437474	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr8:87437474C>T	ENST00000517970.1	+	10	1391	c.1084C>T	c.(1084-1086)Cat>Tat	p.H362Y	WWP1_ENST00000349423.2_Missense_Mutation_p.H144Y|WWP1_ENST00000265428.4_Missense_Mutation_p.H362Y|WWP1_ENST00000341922.2_Missense_Mutation_p.H232Y	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	362	WW 1.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						AAAAGATCCTCATGGTAGAAC	0.353000													44	53					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11333469	11333469	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:11333469C>T	ENST00000294618.7	-	26	3193	c.3182G>A	c.(3181-3183)tGc>tAc	p.C1061Y	DOCK6_ENST00000319867.7_Missense_Mutation_p.C400Y	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1061					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CAGGGGGCAGCAGGGGAGGTT	0.632000													3	14					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27761270	27761270	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:27761270G>A	ENST00000261588.4	+	16	3008	c.2989G>A	c.(2989-2991)Gaa>Aaa	p.E997K		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	997										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						CAACGGAATAGAAATATTCAG	0.483000													15	30					0	0	1	0	0
OR9A4	130075	broad.mit.edu	37	7	141618885	141618885	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:141618885C>T	ENST00000548136.1	+	1	269	c.210C>T	c.(208-210)atC>atT	p.I70I	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					CCCTGGAGATCCTGGTCACAA	0.493000													147	94					0	0	1	0	0
HTR6	3362	broad.mit.edu	37	1	20005724	20005724	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:20005724G>A	ENST00000289753.1	+	3	1653	c.1186G>A	c.(1186-1188)Gcc>Acc	p.A396T		NM_000871.1	NP_000862.1	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	396					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			endometrium(1)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	GCGGCTCACGGCCCAGCTGCT	0.711000													11	8					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62197524	62197524	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr20:62197524G>A	ENST00000467148.1	-	8	2720	c.2651C>T	c.(2650-2652)cCt>cTt	p.P884L	HELZ2_ENST00000427522.2_Missense_Mutation_p.P315L	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		CAGTGCCCCAGGGCTGAGCAG	0.701000													4	19					0	0	1	0	0
MAGEB2	4113	broad.mit.edu	37	X	30237090	30237090	+	Silent	SNP	C	C	T	rs139272287		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:30237090C>T	ENST00000378988.4	+	2	494	c.393C>T	c.(391-393)tcC>tcT	p.S131S		NM_002364.4	NP_002355.2	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	131	MAGE.						protein binding			breast(1)|large_intestine(3)|lung(17)|ovary(1)|skin(1)	23						TAAAAAAGTCCGTTACAAAGG	0.463000													12	26					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3304693	3304693	+	Missense_Mutation	SNP	C	C	A	rs104895142		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:3304693C>A	ENST00000219596.1	-	2	414	c.375G>T	c.(373-375)gaG>gaT	p.E125D	MEFV_ENST00000536379.1_Intron|MEFV_ENST00000339854.4_Intron|MEFV_ENST00000541159.1_Intron	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	125					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	CCTCGTTCCCCTCGGGGTGGT	0.667000													20	37					1.55795e-14	1.6048e-14	1	1	0
ENOX2	10495	broad.mit.edu	37	X	129771337	129771337	+	Missense_Mutation	SNP	G	G	A	rs148433684	byFrequency	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:129771337G>A	ENST00000338144.3	-	12	1681	c.1264C>T	c.(1264-1266)Cgt>Tgt	p.R422C	ENOX2_ENST00000370935.1_Missense_Mutation_p.R393C|ENOX2_ENST00000370927.1_Missense_Mutation_p.R422C|ENOX2_ENST00000394363.1_Missense_Mutation_p.R393C	NM_182314.1	NP_872114.1	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2	422					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(3)	33						AGCTGCCAACGGAGGCTGTCA	0.418000													80	79					0	0	1	0	0
DGKH	160851	broad.mit.edu	37	13	42772653	42772653	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr13:42772653C>T	ENST00000379274.2	+	18	2228	c.1799C>T	c.(1798-1800)tCg>tTg	p.S600L	DGKH_ENST00000498255.2_3'UTR|DGKH_ENST00000538674.1_Missense_Mutation_p.S491L|DGKH_ENST00000261491.4_Missense_Mutation_p.S736L|DGKH_ENST00000536612.1_Missense_Mutation_p.S600L|DGKH_ENST00000540693.1_Missense_Mutation_p.S736L|DGKH_ENST00000337343.4_Missense_Mutation_p.S736L			Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta	736					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding	p.S736L(1)		breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		GCTGGGAGTTCGATTATCAAC	0.413000													28	19					0	0	1	0	0
CDC20	991	broad.mit.edu	37	1	43825262	43825262	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:43825262C>T	ENST00000372462.1	+	2	486	c.283C>T	c.(283-285)Ctg>Ttg	p.L95L	CDC20_ENST00000310955.6_Silent_p.L95L			Q12834	CDC20_HUMAN	cell division cycle 20	95					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	15	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CAGCTTCCTCCTGAGCAAGGA	0.557000													61	68					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168834204	168834204	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:168834204C>T	ENST00000464456.1	-	7	2092	c.892G>A	c.(892-894)Gga>Aga	p.G298R	MECOM_ENST00000433243.2_Missense_Mutation_p.G299R|MECOM_ENST00000460814.1_Missense_Mutation_p.G298R|MECOM_ENST00000264674.3_Missense_Mutation_p.G363R|MECOM_ENST00000494292.1_Missense_Mutation_p.G486R|MECOM_ENST00000472280.1_Missense_Mutation_p.G299R|MECOM_ENST00000392736.3_Missense_Mutation_p.G298R|MECOM_ENST00000468789.1_Missense_Mutation_p.G298R	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						AAAGAAAATCCAGGAGCTGTT	0.473000													36	60					0	0	1	0	0
GPC4	2239	broad.mit.edu	37	X	132548901	132548901	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:132548901C>T	ENST00000370828.3	-	1	617	c.93G>A	c.(91-93)tcG>tcA	p.S31S		NM_001448.2	NP_001439.2	O75487	GPC4_HUMAN	glypican 4	31					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;0.000127)					GTCGCACTTCCGAGCAACTTT	0.637000													86	105					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94046498	94046498	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr14:94046498G>A	ENST00000553484.1	+	19	2591	c.2437G>A	c.(2437-2439)Gag>Aag	p.E813K	UNC79_ENST00000555664.1_Missense_Mutation_p.E813K|UNC79_ENST00000256339.4_Missense_Mutation_p.E636K|UNC79_ENST00000393151.2_Missense_Mutation_p.E813K			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	813						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CTTTCAGATGGAGTTACAAGA	0.403000													34	67					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105153109	105153109	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:105153109G>A	ENST00000428173.2	+	13	1782	c.1479G>A	c.(1477-1479)caG>caA	p.Q493Q	NRK_ENST00000243300.9_Silent_p.Q492Q			Q7Z2Y5	NRK_HUMAN	Nik related kinase	492	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						GGCTTCTGCAGGTACAGTCCC	0.537000										HNSCC(51;0.14)			27	49					0	0	1	0	0
DMWD	1762	broad.mit.edu	37	19	46288930	46288930	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:46288930G>A	ENST00000593999.1	-	1	301	c.302C>T	c.(301-303)tCc>tTc	p.S101F	DMWD_ENST00000377735.3_Silent_p.V608V|DMWD_ENST00000270223.6_Silent_p.V608V																							GGAACAGGAGGACTGTGAGCC	0.682000													22	30					0	0	1	0	0
CYP3A5	1577	broad.mit.edu	37	7	99245936	99245936	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:99245936C>T	ENST00000343703.5	-	14	1857	c.1471G>A	c.(1471-1473)Gga>Aga	p.G491R	CYP3A5_ENST00000339843.2_3'UTR|CYP3A5_ENST00000222982.4_Missense_Mutation_p.G501R					cytochrome P450, family 3, subfamily A, polypeptide 5											NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)					ACTCATTCTCCACTTAGGGTT	0.378000													52	45					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169626382	169626382	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:169626382C>T	ENST00000366787.3	-	17	2680	c.2431G>A	c.(2431-2433)Gaa>Aaa	p.E811K	XXyac-YX65C7_A.2_ENST00000444188.1_RNA	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	811					cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TTGTCTCGTTCATTGAAGACA	0.468000													38	6					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12647616	12647616	+	Silent	SNP	C	C	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:12647616C>A	ENST00000425538.1	+	8	1034	c.834C>A	c.(832-834)tcC>tcA	p.S278S	MYOCD_ENST00000395988.1_Silent_p.S182S|MYOCD_ENST00000343344.4_Silent_p.S278S	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	278					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CAGAGAAGTCCCCTCCACCTA	0.552000													48	47					1.66251e-12	1.69551e-12	1	1	0
IGKV1-8	28942	broad.mit.edu	37	2	89292166	89292166	+	RNA	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:89292166C>T	ENST00000495489.1	-	0	159																											GACTCTGTCTCCTGTAGATGC	0.458000													120	150					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459909	66459909	+	RNA	SNP	T	T	C	rs146531631	by1000genomes	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr9:66459909T>C	ENST00000424345.1	+	0	169																											cattaaaatcttgggcatgca	0.368000													3	13					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33148920	33148920	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:33148920C>T	ENST00000341947.2	-	9	1374	c.1147G>A	c.(1147-1149)Gga>Aga	p.G383R	COL11A2_ENST00000374712.1_Missense_Mutation_p.G302R|COL11A2_ENST00000395197.1_Missense_Mutation_p.G323R|COL11A2_ENST00000374708.4_Missense_Mutation_p.G297R|COL11A2_ENST00000374713.1_Missense_Mutation_p.G336R|COL11A2_ENST00000374714.1_Missense_Mutation_p.G357R|COL11A2_ENST00000357486.1_Missense_Mutation_p.G362R|COL11A2_ENST00000361917.1_Missense_Mutation_p.G276R	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	383	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CCTTTCTCTCCCTTCAGCCCT	0.577000													46	79					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41075606	41075606	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:41075606G>A	ENST00000352632.3	+	32	7086	c.7000G>A	c.(7000-7002)Gag>Aag	p.E2334K	SPTBN4_ENST00000598249.1_Missense_Mutation_p.E2334K|SPTBN4_ENST00000392025.1_Missense_Mutation_p.E1077K			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	2334					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCAGGAGAAAGAGGCAGGCCC	0.597000													13	20					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7637785	7637785	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:7637785G>A	ENST00000359156.4	-	11	2888	c.2686C>T	c.(2686-2688)Cca>Tca	p.P896S	CD163_ENST00000396620.3_Missense_Mutation_p.P929S|CD163_ENST00000539632.1_5'UTR|CD163_ENST00000432237.2_Missense_Mutation_p.P896S|CD163_ENST00000541972.1_Missense_Mutation_p.P884S	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	896	SRCR 8.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						GGTCCTTTTGGACACTGAACA	0.547000													63	69					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176679284	176679284	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:176679284C>T	ENST00000367662.3	+	11	4787	c.3623C>T	c.(3622-3624)tCc>tTc	p.S1208F		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1208					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TGTCCTGTTTCCTTGGTAACT	0.463000													83	58					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64876733	64876733	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:64876733T>C	ENST00000533854.1	+	4	580	c.343T>C	c.(343-345)Ttt>Ctt	p.F115L	CACNG5_ENST00000169565.3_Missense_Mutation_p.F115L|CACNG5_ENST00000307139.3_Missense_Mutation_p.F115L			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	115					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			GTTCATTGGGTTTATCCTGAA	0.507000													93	104					0	0	1	0	0
H2AFY2	55506	broad.mit.edu	37	10	71868922	71868922	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr10:71868922G>A	ENST00000373255.4	+	8	1176	c.912G>A	c.(910-912)aaG>aaA	p.K304K	AIFM2_ENST00000373248.1_Intron	NM_018649.2	NP_061119.1	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	304	Macro.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(4)|skin(1)	15						CGGAGGACAAGAAGCTAAAGT	0.532000													34	69					0	0	1	0	0
ACOT11	26027	broad.mit.edu	37	1	55060287	55060287	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:55060287C>T	ENST00000371316.3	+	6	612	c.530C>T	c.(529-531)gCg>gTg	p.A177V	ACOT11_ENST00000343744.2_Missense_Mutation_p.A177V|ACOT11_ENST00000481208.1_3'UTR	NM_015547.3	NP_056362.1	Q8WXI4	ACO11_HUMAN	acyl-CoA thioesterase 11	177					fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(3)|lung(5)|ovary(1)	17						CACAGTGTGGCGGCTGAGCGC	0.632000													10	83					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57646651	57646651	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:57646651C>T	ENST00000269834.1	-	5	1439	c.1054G>A	c.(1054-1056)Gat>Aat	p.D352N		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.D352N(2)		breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTCTCATGATCGATGACATTG	0.383000													98	108					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21069125	21069125	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:21069125G>A	ENST00000381545.3	+	16	2272	c.2053G>A	c.(2053-2055)Gga>Aga	p.G685R	LST3_ENST00000540229.1_Intron|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.G685R|SLCO1B3_ENST00000553473.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	685					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					ACCTTCTGCTGGAACAGATAG	0.353000													43	42					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111022256	111022256	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:111022256C>T	ENST00000262839.2	-	10	3107	c.2189G>A	c.(2188-2190)aGa>aAa	p.R730K		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	730					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TTTGGAATTTCTTATCATAGC	0.323000													27	51					0	0	1	0	0
RGL1	23179	broad.mit.edu	37	1	183885614	183885614	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:183885614C>T	ENST00000304685.3	+	17	2349	c.1888C>T	c.(1888-1890)Cat>Tat	p.H630Y	RGL1_ENST00000367531.1_Missense_Mutation_p.H630Y|RGL1_ENST00000539189.1_Missense_Mutation_p.H566Y|RGL1_ENST00000536277.1_Missense_Mutation_p.H593Y|RGL1_ENST00000360851.3_Missense_Mutation_p.H595Y	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	595					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						TTCTTCTATCCATTCCATGGA	0.483000													72	164					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113376793	113376793	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:113376793G>A	ENST00000316407.4	-	7	4146	c.3736C>T	c.(3736-3738)Cat>Tat	p.H1246Y	KIAA2018_ENST00000478658.1_Missense_Mutation_p.H1246Y|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1246					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						CTGCTCTGATGGATAAGATTA	0.443000													40	43					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160729052	160729052	+	Missense_Mutation	SNP	C	C	T	rs115433124	by1000genomes	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:160729052C>T	ENST00000263636.4	-	13	2054	c.2027G>A	c.(2026-2028)cGa>cAa	p.R676Q	LY75_ENST00000553424.1_Missense_Mutation_p.R676Q|LY75-CD302_ENST00000504764.1_Missense_Mutation_p.R676Q|LY75_ENST00000554112.1_Missense_Mutation_p.R676Q|LY75-CD302_ENST00000505052.1_Missense_Mutation_p.R676Q	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		TTGGCAGAATCGTTCAGCTTC	0.353000													80	119					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48367872	48367872	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:48367872C>T	ENST00000380518.3	-	53	4481	c.4317_splice	c.e53+1	p.T1439_splice	COL2A1_ENST00000493991.1_5'UTR|COL2A1_ENST00000337299.6_Splice_Site_p.T1370_splice	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	1439	Fibrillar collagen NC1.		T -> M (in SEDC).		axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CCCCACTCACCGTGCAGCCAT	0.622000													57	65					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47887258	47887258	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr20:47887258C>T	ENST00000396105.1	-	3	1337	c.1091G>A	c.(1090-1092)aGc>aAc	p.S364N	ZNFX1_ENST00000371752.1_Missense_Mutation_p.S364N|ZNFX1_ENST00000371754.4_Missense_Mutation_p.S364N	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	364							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GATAGCAGTGCTGTCGTATTT	0.478000													76	182					0	0	1	0	0
ST7	7982	broad.mit.edu	37	7	116859151	116859151	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:116859151C>T	ENST00000265437.5	+	14	1633	c.1419C>T	c.(1417-1419)atC>atT	p.I473I	ST7_ENST00000432298.1_Silent_p.I427I|ST7_ENST00000393449.1_Silent_p.I468I|ST7_ENST00000393444.3_Silent_p.I407I|ST7_ENST00000393446.2_Intron|ST7_ENST00000393447.4_Silent_p.I430I|ST7_ENST00000323984.3_Silent_p.I473I|ST7_ENST00000393443.1_Silent_p.I395I|ST7_ENST00000422922.1_Silent_p.I404I|ST7_ENST00000393451.3_Silent_p.I450I	NM_021908.2	NP_068708.1	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7	473						integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(1)	21	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		TTCGGATGATCCCTTATCCCT	0.423000													163	123					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17052040	17052040	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:17052040C>T	ENST00000418129.2	+	2	1289	c.824C>T	c.(823-825)tCc>tTc	p.S275F	PLCL2_ENST00000432376.1_Missense_Mutation_p.S275F|PLCL2_ENST00000396755.2_Missense_Mutation_p.S275F|PLCL2_ENST00000460467.1_Intron	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	401					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						GGCTGGCTCTCCATAGACGGG	0.418000													52	78					0	0	1	0	0
MFHAS1	9258	broad.mit.edu	37	8	8748178	8748178	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr8:8748178G>A	ENST00000276282.6	-	1	2977	c.2391C>T	c.(2389-2391)ctC>ctT	p.L797L		NM_004225.2	NP_004216.2	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified sequence 1	797										endometrium(1)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|stomach(1)	21		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		GAGCTGGCAAGAGCCCATGCA	0.607000													45	57					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49179561	49179561	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr11:49179561G>A	ENST00000340334.7	-	15	1798	c.1430C>T	c.(1429-1431)tCt>tTt	p.S477F	FOLH1_ENST00000343844.4_Missense_Mutation_p.S184F|FOLH1_ENST00000256999.2_Missense_Mutation_p.S492F|FOLH1_ENST00000356696.3_Missense_Mutation_p.S492F|FOLH1_ENST00000533034.1_Missense_Mutation_p.S477F	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	492	NAALADase.				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TTCATAAAGAGATTTGCCTTC	0.353000													33	30					0	0	1	0	0
ZNF30	90075	broad.mit.edu	37	19	35420854	35420854	+	Translation_Start_Site	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:35420854G>A	ENST00000439785.1	+	2	447	c.3G>A	c.(1-3)atG>atA	p.M1I	ZNF30_ENST00000303586.7_Start_Codon_SNP_p.M1I|ZNF30_ENST00000601540.1_3'UTR|ZNF30_ENST00000601142.1_Start_Codon_SNP_p.M1I|ZNF30_ENST00000601957.1_Start_Codon_SNP_p.M1I|ZNF30_ENST00000426813.2_5'UTR	NM_001099438.1	NP_001092908.1	P17039	ZNF30_HUMAN	zinc finger protein 30	1					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)	16	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		CTCAAAGCATGGCCCATGTAA	0.383000													4	14					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9063580	9063580	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:9063580C>T	ENST00000397910.4	-	3	24069	c.23866G>A	c.(23866-23868)Gat>Aat	p.D7956N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7958	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CATGATACATCCTCAGGACCC	0.468000													29	32					0	0	1	0	0
C4A	720	broad.mit.edu	37	6	31962395	31962395	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:31962395G>A	ENST00000428956.2	+	21	2797	c.2713G>A	c.(2713-2715)Gca>Aca	p.A905T	C4A_ENST00000498271.1_Missense_Mutation_p.A905T	NM_007293.2	NP_009224.2			complement component 4A (Rodgers blood group)																		GGTGCCCACGGCAGCCGCCGC	0.662000													24	145					0	0	1	0	0
CIAPIN1	57019	broad.mit.edu	37	16	57465147	57465147	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:57465147G>A	ENST00000394391.4	-	7	903	c.662C>T	c.(661-663)cCa>cTa	p.P221L	CIAPIN1_ENST00000569246.1_5'UTR|CIAPIN1_ENST00000569979.1_Intron|CIAPIN1_ENST00000565961.1_Intron|CIAPIN1_ENST00000568940.1_Intron|CIAPIN1_ENST00000567518.1_Missense_Mutation_p.P208L|CIAPIN1_ENST00000569370.1_Intron	NM_020313.2	NP_064709.2	Q6FI81	CPIN1_HUMAN	cytokine induced apoptosis inhibitor 1	221					anti-apoptosis|apoptosis	cytoplasm|nucleolus				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	10						CAAATCTTCTGGATCCAGCAG	0.493000													51	63					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27297912	27297912	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr8:27297912G>A	ENST00000397501.1	+	26	2801	c.1993G>A	c.(1993-1995)Gac>Aac	p.D665N	PTK2B_ENST00000420218.2_Missense_Mutation_p.D665N|PTK2B_ENST00000517339.1_Missense_Mutation_p.D665N|PTK2B_ENST00000544172.1_Missense_Mutation_p.D665N|PTK2B_ENST00000346049.5_Missense_Mutation_p.D665N|PTK2B_ENST00000397497.4_Missense_Mutation_p.D411N|PTK2B_ENST00000338238.4_Missense_Mutation_p.D665N	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	665	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		CTGGGACTACGACCCCAGTGA	0.652000													57	47					0	0	1	0	0
NFKBIB	4793	broad.mit.edu	37	19	39396030	39396030	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:39396030C>T	ENST00000392079.3	+	3	476	c.378C>T	c.(376-378)ccC>ccT	p.P126P	NFKBIB_ENST00000313582.5_Silent_p.P158P|NFKBIB_ENST00000572515.1_Silent_p.P158P			Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	158					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)	8	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			GGGAAGCCCCCGACACCTACC	0.687000													57	57					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1097824	1097824	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr11:1097824C>T	ENST00000441003.2	+	36	6944	c.6917C>T	c.(6916-6918)aCc>aTc	p.T2306I	MUC2_ENST00000361558.6_3'UTR	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4668						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	AGCTCCACGACCAAGCGCCCG	0.662000													14	3					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113444977	113444977	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr9:113444977G>A	ENST00000416899.2	+	2	229	c.103G>A	c.(103-105)Gaa>Aaa	p.E35K	MUSK_ENST00000189978.5_Missense_Mutation_p.E35K|MUSK_ENST00000374440.3_5'UTR|MUSK_ENST00000374448.4_Missense_Mutation_p.E35K			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	35	Ig-like 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						CACTCCTCTTGAAACAGTGGA	0.418000													113	19					0	0	1	0	0
GPR125	166647	broad.mit.edu	37	4	22475441	22475441	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr4:22475441C>T	ENST00000334304.5	-	2	552	c.283G>A	c.(283-285)Gag>Aag	p.E95K	GPR125_ENST00000502482.1_Missense_Mutation_p.E95K	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	95					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				TTCTTCAGCTCGGATATCTTA	0.269000													10	74					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28576947	28576947	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr18:28576947C>T	ENST00000434452.1	-	15	2457	c.2303G>A	c.(2302-2304)gGa>gAa	p.G768E	DSC3_ENST00000360428.4_Missense_Mutation_p.G768E	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	768					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CATTCCTGATCCCATAGTACC	0.433000													34	45					0	0	1	0	0
GAS2L2	246176	broad.mit.edu	37	17	34071968	34071968	+	Missense_Mutation	SNP	C	C	T	rs145918686	byFrequency	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:34071968C>T	ENST00000254466.6	-	6	2575	c.2548G>A	c.(2548-2550)Gct>Act	p.A850T	GAS2L2_ENST00000587565.1_Missense_Mutation_p.A834T	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	850					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TCCAATGGAGCGGCTGGctct	0.612000													24	28					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10738633	10738633	+	Silent	SNP	C	C	T	rs146675623		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:10738633C>T	ENST00000586078.1	+	4	307	c.198C>T	c.(196-198)ccC>ccT	p.P66P	SLC44A2_ENST00000407327.4_Silent_p.P64P|SLC44A2_ENST00000335757.5_Silent_p.P66P	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	66					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	TGATCTACCCCACTGACAGCC	0.587000													22	24					0	0	1	0	0
RGL1	23179	broad.mit.edu	37	1	183849803	183849803	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:183849803G>A	ENST00000304685.3	+	6	1045	c.584G>A	c.(583-585)cGa>cAa	p.R195Q	RGL1_ENST00000367531.1_Missense_Mutation_p.R195Q|RGL1_ENST00000539189.1_Missense_Mutation_p.R160Q|RGL1_ENST00000536277.1_Missense_Mutation_p.R158Q|RGL1_ENST00000360851.3_Missense_Mutation_p.R160Q	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	160	N-terminal Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						GAAGACTTCCGAGAGCCCCCT	0.517000													115	83					0	0	1	0	0
ZNF226	7769	broad.mit.edu	37	19	44679946	44679946	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:44679946C>T	ENST00000590089.1	+	7	898	c.531C>T	c.(529-531)ttC>ttT	p.F177F	ZNF226_ENST00000588883.1_3'UTR|ZNF226_ENST00000337433.5_Silent_p.F177F|ZNF226_ENST00000454662.2_Silent_p.F177F			Q9NYT6	ZN226_HUMAN	zinc finger protein 226	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				GGAAAACATTCCTGACTGAGT	0.373000													18	22					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61512110	61512110	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr20:61512110G>A	ENST00000266070.4	-	16	5523	c.5198C>T	c.(5197-5199)aCc>aTc	p.T1733I	DIDO1_ENST00000395343.1_Missense_Mutation_p.T1733I	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1733	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GAGCGGGGCGGTGCCCTCGCC	0.627000													160	95					0	0	1	0	0
UBE3C	9690	broad.mit.edu	37	7	157000112	157000112	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:157000112A>G	ENST00000348165.5	+	12	1799	c.1439A>G	c.(1438-1440)cAg>cGg	p.Q480R		NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	480					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		CCGTTGCTTCAGGTGATATCC	0.338000													55	199					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152514587	152514587	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:152514587G>A	ENST00000427231.2	-	48	6295	c.6093C>T	c.(6091-6093)tcC>tcT	p.S2031S	NEB_ENST00000604864.1_Silent_p.S2031S|NEB_ENST00000397345.3_Silent_p.S2031S|NEB_ENST00000409198.1_Silent_p.S2031S|NEB_ENST00000172853.10_Silent_p.S2031S|NEB_ENST00000603639.1_Silent_p.S2031S	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2031					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ACTCTTCCAAGGAAAGTTTGT	0.388000													9	7					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79579661	79579661	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr10:79579661G>A	ENST00000372391.2	-	16	3523	c.3518C>T	c.(3517-3519)cCg>cTg	p.P1173L	DLG5_ENST00000372388.2_Missense_Mutation_p.P833L|DLG5_ENST00000459739.1_5'UTR	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1173					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			ACCCACAGACGGCCTGCTAGG	0.652000													63	147					0	0	1	0	0
WASH6P	653440	broad.mit.edu	37	X	155252854	155252854	+	RNA	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:155252854G>A	ENST00000285718.7	+	0	805				WASH6P_ENST00000461007.1_RNA																							CTTCCACACTGAGGTAGCCGA	0.652000													4	12					0	0	1	0	0
TWIST1	7291	broad.mit.edu	37	7	19156582	19156582	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:19156582G>A	ENST00000242261.5	-	1	713	c.363C>T	c.(361-363)acC>acT	p.T121T		NM_000474.3	NP_000465.1	Q15672	TWST1_HUMAN	twist family bHLH transcription factor 1	121	Helix-loop-helix motif.				aortic valve morphogenesis|cellular response to hypoxia|embryonic camera-type eye formation|embryonic cranial skeleton morphogenesis|eyelid development in camera-type eye|muscle organ development|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of histone phosphorylation|negative regulation of osteoblast differentiation|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of cell motility|positive regulation of epithelial to mesenchymal transition|positive regulation of fatty acid beta-oxidation|positive regulation of monocyte chemotactic protein-1 production|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of tumor necrosis factor production|regulation of bone mineralization	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			lung(2)|upper_aerodigestive_tract(1)	3						TCAGCGACTGGGTGCGCTGGC	0.697000													40	29					0	0	1	0	0
SASH1	23328	broad.mit.edu	37	6	148865642	148865642	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:148865642C>T	ENST00000367467.3	+	18	3511	c.3036C>T	c.(3034-3036)ccC>ccT	p.P1012P		NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	1012	Pro-rich.						protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		GGGCCCTCCCCAGTCCCGATG	0.642000													44	13					0	0	1	0	0
AP1G2	8906	broad.mit.edu	37	14	24031578	24031578	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr14:24031578G>A	ENST00000308724.5	-	15	2302	c.1547C>T	c.(1546-1548)tCc>tTc	p.S516F	RP11-66N24.3_ENST00000555968.1_RNA|AP1G2_ENST00000397120.3_Missense_Mutation_p.S516F	NM_003917.2	NP_003908.1	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2 subunit	516					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	28	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		GGACATGTGGGACTGCAGCAC	0.572000											OREG0022605	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	65	66					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													7	72					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75893829	75893829	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:75893829C>T	ENST00000322507.8	-	9	1338	c.1029G>A	c.(1027-1029)atG>atA	p.M343I	COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000483888.2_Missense_Mutation_p.M343I|COL12A1_ENST00000416123.2_Missense_Mutation_p.M343I	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	343	Fibronectin type-III 2.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						AAGAGACTTCCATGGCAATCA	0.393000													41	53					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11550485	11550485	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:11550485G>A	ENST00000262442.3	+	12	2135	c.2067G>A	c.(2065-2067)acG>acA	p.T689T	DNAH9_ENST00000454412.2_Silent_p.T689T	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	689	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ACCCAGAGACGAAGGAGATCA	0.443000													115	133					0	0	1	0	0
GLIS3	169792	broad.mit.edu	37	9	4118481	4118481	+	Missense_Mutation	SNP	C	C	G			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr9:4118481C>G	ENST00000324333.10	-	3	725	c.532G>C	c.(532-534)Ggg>Cgg	p.G178R	GLIS3_ENST00000381971.3_Missense_Mutation_p.G333R	NM_152629.3	NP_689842.3	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	178					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GCCCTCGACCCGTTGATGTAG	0.657000													42	14					0	0	1	0	0
R3HDM4	91300	broad.mit.edu	37	19	900088	900088	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:900088G>A	ENST00000361574.5	-	5	607	c.534C>T	c.(532-534)gcC>gcT	p.A178A	R3HDM4_ENST00000587975.1_Silent_p.A157A	NM_138774.3	NP_620129.2	Q96D70	CS022_HUMAN	R3H domain containing 4	178	Arg-rich.					nucleus	nucleic acid binding										GCTTGAGGACGGCTCGCAGAC	0.642000													29	56					0	0	1	0	0
ERP29	10961	broad.mit.edu	37	12	112460034	112460034	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:112460034C>T	ENST00000261735.3	+	3	514	c.364C>T	c.(364-366)Cgg>Tgg	p.R122W	ERP29_ENST00000546477.1_Missense_Mutation_p.R21W|ERP29_ENST00000455836.1_3'UTR	NM_006817.3	NP_006808.1	P30040	ERP29_HUMAN	endoplasmic reticulum protein 29	122					intracellular protein transport|protein folding|protein secretion	endoplasmic reticulum lumen|melanosome	protein disulfide isomerase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	5						CTACCTCTTCCGGGATGGGGA	0.527000													30	44					0	0	1	0	0
C16orf93	90835	broad.mit.edu	37	16	30768807	30768807	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:30768807T>A	ENST00000543610.1	-	9	1947	c.986A>T	c.(985-987)aAg>aTg	p.K329M	PHKG2_ENST00000563588.1_3'UTR|PHKG2_ENST00000424889.3_Intron|C16orf93_ENST00000541260.1_Missense_Mutation_p.K394M	NM_001014979.2	NP_001014979.2	A1A4V9	CP093_HUMAN	chromosome 16 open reading frame 93	329										breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(6)	11						TCACTTGGTCTTGCTCTTGCC	0.592000													168	221					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131912223	131912223	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:131912223G>A	ENST00000359827.3	-	7	2831	c.1869C>T	c.(1867-1869)atC>atT	p.I623I	PLXNA4_ENST00000321063.4_Silent_p.I623I			Q9HCM2	PLXA4_HUMAN	plexin A4	623						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TCTCTGTGATGATCCGGGGCA	0.572000													33	55					0	0	1	0	0
PLIN1	5346	broad.mit.edu	37	15	90210254	90210254	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr15:90210254G>A	ENST00000300055.5	-	8	1287	c.1122C>T	c.(1120-1122)tcC>tcT	p.S374S	PLIN1_ENST00000430628.2_Silent_p.S374S	NM_002666.4	NP_002657.3	O60240	PLIN1_HUMAN	perilipin 1	374					triglyceride catabolic process	lipid particle	lipid binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(2)	13						CCTTGGTTGAGGAGACAGCAG	0.617000													35	29					0	0	1	0	0
DDX11	1663	broad.mit.edu	37	12	31254897	31254897	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:31254897G>A	ENST00000407793.2	+	21	2434	c.2183G>A	c.(2182-2184)cGt>cAt	p.R728H	DDX11_ENST00000545668.1_Missense_Mutation_p.R728H|DDX11_ENST00000350437.4_Intron|DDX11_ENST00000542838.1_Missense_Mutation_p.R728H|DDX11_ENST00000251758.5_3'UTR|DDX11_ENST00000228264.6_Missense_Mutation_p.R702H	NM_030653.3|NM_152438.1	NP_085911.2|NP_689651.1	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	728					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CTGCTGGGCCGTCTGGCTGCC	0.637000										Multiple Myeloma(12;0.14)			4	51					0	0	1	0	0
MAP2K3	5606	broad.mit.edu	37	17	21206546	21206546	+	Splice_Site	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr17:21206546G>A	ENST00000342679.4	+	7	817	c.568_splice	c.e7+1	p.D190_splice	MAP2K3_ENST00000316920.6_Splice_Site_p.D161_splice|MAP2K3_ENST00000361818.5_Splice_Site_p.D161_splice	NM_145109.2	NP_659731.1	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	190	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity								COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		GATCCACAGAGGTCAGTGCCC	0.642000													9	46					0	0	1	0	0
HAUS5	23354	broad.mit.edu	37	19	36108240	36108240	+	Silent	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:36108240C>T	ENST00000203166.5	+	8	632	c.607C>T	c.(607-609)Ctg>Ttg	p.L203L	HAUS5_ENST00000379045.2_Silent_p.L203L	NM_015302.1	NP_056117.1	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	203					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				NS(1)|breast(2)|cervix(3)|endometrium(1)|large_intestine(2)|lung(5)|skin(2)	16						GCAGAACCTCCTGCTTCCCCA	0.597000													36	72					0	0	1	0	0
ZNF502	91392	broad.mit.edu	37	3	44763753	44763753	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:44763753C>T	ENST00000296091.4	+	4	1700	c.1444C>T	c.(1444-1446)Cat>Tat	p.H482Y	ZNF502_ENST00000449836.1_Missense_Mutation_p.H482Y|ZNF502_ENST00000436624.2_Missense_Mutation_p.H482Y	NM_001134440.1|NM_033210.4	NP_001127912.1|NP_149987.2	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	482					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(8)|lung(4)|prostate(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		TACTGAACATCATAGAACTCA	0.413000													27	53					0	0	1	0	0
IARS2	55699	broad.mit.edu	37	1	220284153	220284153	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:220284153G>T	ENST00000366922.1	+	11	1468	c.1137G>T	c.(1135-1137)aaG>aaT	p.K379N	IARS2_ENST00000302637.5_Missense_Mutation_p.K451N			Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	451					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	AGACTGCAAAGAATTTGTTGA	0.343000													9	137					0.000442599	0.00044805	1	1	0
COL11A2	1302	broad.mit.edu	37	6	33136330	33136330	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:33136330C>T	ENST00000341947.2	-	54	4153	c.3926G>A	c.(3925-3927)gGg>gAg	p.G1309E	COL11A2_ENST00000374712.1_Missense_Mutation_p.G1228E|COL11A2_ENST00000395197.1_Missense_Mutation_p.G1249E|COL11A2_ENST00000374708.4_Missense_Mutation_p.G1223E|COL11A2_ENST00000374713.1_Missense_Mutation_p.G1262E|COL11A2_ENST00000374714.1_Missense_Mutation_p.G1283E|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000357486.1_Missense_Mutation_p.G1288E|COL11A2_ENST00000361917.1_Missense_Mutation_p.G1202E	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1309	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TCCATTCTCCCCGGTGGGACC	0.632000													25	33					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659741	24659741	+	RNA	SNP	G	G	A	rs144618782	by1000genomes	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr22:24659741G>A	ENST00000414583.2	+	0	3266					NR_003714.1																						CTGTGGGAGGGGGGAATGTTC	0.622000													3	34					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123814011	123814011	+	Missense_Mutation	SNP	G	G	A	rs140103246		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr11:123814011G>A	ENST00000321252.2	-	1	569	c.535C>T	c.(535-537)Cgt>Tgt	p.R179C		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R179C(1)		breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CAACTGTCACGAAAGAAGTGG	0.572000													36	8					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137814764	137814764	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:137814764C>T	ENST00000409968.1	+	3	1092	c.914C>T	c.(913-915)tCg>tTg	p.S305L	THSD7B_ENST00000272643.3_Missense_Mutation_p.S305L|THSD7B_ENST00000413152.2_Missense_Mutation_p.S274L|THSD7B_ENST00000543459.1_Missense_Mutation_p.S164L					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CGGCAGGTTTCGTGTACAAGA	0.363000													19	16					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18633644	18633644	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:18633644G>A	ENST00000406451.3	+	6	797	c.647G>A	c.(646-648)cGa>cAa	p.R216Q	HDAC9_ENST00000417496.2_Missense_Mutation_p.R258Q|HDAC9_ENST00000406072.1_Missense_Mutation_p.R247Q|HDAC9_ENST00000405010.3_Missense_Mutation_p.R216Q|HDAC9_ENST00000428307.2_Missense_Mutation_p.R216Q|HDAC9_ENST00000441542.2_Missense_Mutation_p.R219Q|HDAC9_ENST00000432645.2_Missense_Mutation_p.R216Q|HDAC9_ENST00000401921.1_Missense_Mutation_p.R219Q|HDAC9_ENST00000456174.2_Missense_Mutation_p.R188Q|HDAC9_ENST00000524023.1_Missense_Mutation_p.R183Q	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	216	Interaction with MAPK10 (By similarity).				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TTCCCCCTTCGAAAAACTGGT	0.418000													42	101					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9066398	9066398	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:9066398G>A	ENST00000397910.4	-	3	21251	c.21048C>T	c.(21046-21048)ctC>ctT	p.L7016L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7018	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCGAGGCAAAGAGCCTTGTCA	0.502000													109	144					0	0	1	0	0
GTPBP2	54676	broad.mit.edu	37	6	43593277	43593277	+	Silent	SNP	G	G	A			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:43593277G>A	ENST00000307126.5	-	5	527	c.528C>T	c.(526-528)gcC>gcT	p.A176A	GTPBP2_ENST00000307114.7_Silent_p.A88A|GTPBP2_ENST00000476510.1_5'UTR	NM_019096.3	NP_061969.3	Q9BX10	GTPB2_HUMAN	GTP binding protein 2	176							GTP binding|GTPase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000501)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			TCCCCAGGACGGCCACACGGA	0.577000													35	48					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118222590	118222590	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:118222590C>T	ENST00000402510.2	-	11	2602	c.2603G>A	c.(2602-2604)aGc>aAc	p.S868N		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	868										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						TTCCTCTGAGCTGCTGCAATC	0.473000													28	16					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82583260	82583260	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:82583260C>T	ENST00000423517.2	-	5	7346	c.7009G>A	c.(7009-7011)Gaa>Aaa	p.E2337K	PCLO_ENST00000333891.8_Missense_Mutation_p.E2337K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2268	Poly-Pro.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AACACGGTTTCGGATAAGCTA	0.428000													111	91					0	0	1	0	0
MGLL	11343	broad.mit.edu	37	3	127411100	127411100	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:127411100C>T	ENST00000434178.2	-	8	1749	c.853G>A	c.(853-855)Gaa>Aaa	p.E285K	MGLL_ENST00000476682.1_5'UTR|MGLL_ENST00000453507.2_Missense_Mutation_p.E265K|MGLL_ENST00000265052.5_Missense_Mutation_p.E295K|MGLL_ENST00000398101.3_Missense_Mutation_p.E259K|MGLL_ENST00000398104.1_Missense_Mutation_p.E285K			Q99685	MGLL_HUMAN	monoglyceride lipase	285					arachidonic acid metabolic process|fatty acid biosynthetic process|inflammatory response|platelet activation|regulation of endocannabinoid signaling pathway|regulation of inflammatory response|regulation of sensory perception of pain|triglyceride catabolic process	plasma membrane	acylglycerol lipase activity|carboxylesterase activity|lysophospholipase activity|protein homodimerization activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6						ATGTTTATTTCATGGAAGACG	0.542000													57	80					0	0	1	0	0
RP11-782C8.2	0	broad.mit.edu	37	1	143179972	143179972	+	RNA	DEL	G	G	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:143179972delG	ENST00000412204.2	-	0	2503				RP11-782C8.1_ENST00000438000.1_lincRNA																							gaagttaaaagggtgtttgtt	0.393													3	4	---	---	---	---					
LOC101927648	101927648	broad.mit.edu	37	1	143411910	143411910	+	RNA	DEL	G	G	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:143411910delG	ENST00000423249.1	-	0	59																											AGGTGGGTAAGGGGGGGAGGA	0.537													3	6	---	---	---	---					
RP11-496N12.6	0	broad.mit.edu	37	1	225638760	225638760	+	RNA	DEL	T	T	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:225638760delT	ENST00000433058.1	-	0	61																											cctcctcctctgaccctcttc	0.572													4	2	---	---	---	---					
RP11-145A3.1	0	broad.mit.edu	37	1	225930380	225930383	+	RNA	DEL	AAAA	AAAA	-	rs77298029		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr1:225930380_225930383delAAAA	ENST00000448264.1	+	0	606																											actccatgtcaaaaaaaaaaaaaa	0.471													3	4	---	---	---	---					
AC010880.1	0	broad.mit.edu	37	2	16577389	16577390	+	RNA	DEL	AC	AC	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:16577389_16577390delAC	ENST00000427950.1	+	0	157																											agacagatgtacacacacacac	0.475													2	4	---	---	---	---					
AC013472.4	0	broad.mit.edu	37	2	27188282	27188282	+	RNA	DEL	C	C	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:27188282delC	ENST00000416226.1	-	0	32																											gaggctgaagcaggagaatcg	0.532													2	4	---	---	---	---					
AC012593.1	0	broad.mit.edu	37	2	35058823	35058824	+	RNA	INS	-	-	AAC	rs78091453	by1000genomes	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:35058823_35058824insAAC	ENST00000588944.1	+	0	115																											aggagaagaagaacaacaagaa	0.411													3	6	---	---	---	---					
IGKV3D-20	28874	broad.mit.edu	37	2	90077776	90077778	+	RNA	DEL	CAT	CAT	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:90077776_90077778delCAT	ENST00000390270.2	+	0	97_99																											CAGAGGGAACCATGGAAACCCCA	0.571													67	119	---	---	---	---					
AC027612.3	0	broad.mit.edu	37	2	91895818	91895818	+	RNA	DEL	G	G	-	rs72492119		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:91895818delG	ENST00000436174.1	-	0	168																											AGTTTTTTTTGgtttgttttt	0.363													4	3	---	---	---	---					
ITPRIPL1	150771	broad.mit.edu	37	2	96992793	96992795	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:96992793_96992795delGAG	ENST00000361124.4	+	1	859_861	c.448_450delGAG	c.(448-450)del	p.E155del	ITPRIPL1_ENST00000536814.1_In_Frame_Del_p.E139del|ITPRIPL1_ENST00000542887.1_In_Frame_Del_p.E139del|ITPRIPL1_ENST00000439118.2_In_Frame_Del_p.E147del	NM_178495.5	NP_848590.3	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	147						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTCCAGCAGTGAGGAGGAGGAGG	0.532													7	107	---	---	---	---					
LOC101927641	101927641	broad.mit.edu	37	2	200522016	200522017	+	RNA	INS	-	-	T	rs145117118	by1000genomes	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:200522016_200522017insT	ENST00000439734.1	+	0	2157																											attctgttctgttttttcagtc	0.351													3	4	---	---	---	---					
DUSP28	285193	broad.mit.edu	37	2	241500275	241500298	+	In_Frame_Del	DEL	GCGCGCGCCCGGCGTGGCAGAGCT	GCGCGCGCCCGGCGTGGCAGAGCT	-	rs114887011	by1000genomes	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr2:241500275_241500298delGCGCGCGCCCGGCGTGGCAGAGCT	ENST00000405954.1	+	1	557_580	c.174_197delGCGCGCGCCCGGCGTGGCAGAGCT	c.(172-198)ccg>cc	p.PRAPGVAEL58del	DUSP28_ENST00000343217.2_In_Frame_Del_p.PRAPGVAEL58del|ANKMY1_ENST00000405002.1_5'UTR|ANKMY1_ENST00000536462.1_Intron|ANKMY1_ENST00000403283.1_In_Frame_Del_p.SSATPGAR24del			Q4G0W2	DUS28_HUMAN	dual specificity phosphatase 28	58							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			lung(2)|upper_aerodigestive_tract(1)	3		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-31)|all cancers(36;5.56e-29)|OV - Ovarian serous cystadenocarcinoma(60;7.57e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.06e-06)|Lung(119;0.00164)|Colorectal(34;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.00802)|COAD - Colon adenocarcinoma(134;0.0311)		AgcccggcccgcgcgcgcccggcgTGGCAGAGCTGCGCGTGCCC	0.786													4	5	---	---	---	---					
RP11-553L6.2	0	broad.mit.edu	37	3	113951739	113951739	+	RNA	DEL	C	C	-	rs75864387		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:113951739delC	ENST00000493033.1	+	0	160				RP11-553L6.2_ENST00000481773.1_RNA																							CTGCCCCCTGCCCCCCCCCCA	0.652													5	6	---	---	---	---					
PBX2P1	5088	broad.mit.edu	37	3	142895155	142895155	+	RNA	DEL	C	C	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:142895155delC	ENST00000560287.1	+	0	29																											GGCCTCAGGGCCCCCCCCCAG	0.746													4	5	---	---	---	---					
LINC01324	104355289	broad.mit.edu	37	3	164519031	164519031	+	RNA	DEL	T	T	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr3:164519031delT	ENST00000497379.2	-	0	67																											TGTGTGTGTGTTTTTTTTTTC	0.294													2	4	---	---	---	---					
CPEB2	132864	broad.mit.edu	37	4	15005738	15005739	+	In_Frame_Ins	INS	-	-	GCG			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr4:15005738_15005739insGCG	ENST00000538197.1	+	1	1441_1442	c.1441_1442insGCG	c.(1441-1443)cgg>GCGcgg	p.480_481insA	CPEB2_ENST00000259997.5_In_Frame_Ins_p.43_44insA|CPEB2_ENST00000507071.1_In_Frame_Ins_p.43_44insA|CPEB2_ENST00000541112.1_In_Frame_Ins_p.480_481insA|CPEB2_ENST00000382401.3_In_Frame_Ins_p.43_44insA|CPEB2_ENST00000442003.2_In_Frame_Ins_p.480_481insA|CPEB2_ENST00000382395.3_In_Frame_Ins_p.43_44insA|CPEB2_ENST00000345451.3_In_Frame_Ins_p.43_44insA	NM_001177382.1	NP_001170853.1	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding protein 2	43	RRM 2.				regulation of translation	cytoplasm	nucleotide binding|RNA binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|skin(3)	14						CGTTCCGACGAgcggcggcggc	0.728													11	15	---	---	---	---					
RP11-445O3.2	0	broad.mit.edu	37	5	4581232	4581233	+	RNA	DEL	CA	CA	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr5:4581232_4581233delCA	ENST00000507435.1	-	0	429																											gacactcttgcacacacacaca	0.559													2	4	---	---	---	---					
RP11-155G15.2	0	broad.mit.edu	37	5	96627919	96627919	+	RNA	DEL	C	C	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr5:96627919delC	ENST00000504578.1	+	0	71																											tgtgatgtatcacatattaaa	0.338													2	4	---	---	---	---					
ADRA1B	147	broad.mit.edu	37	5	159344616	159344624	+	In_Frame_Del	DEL	AGAACCTAG	AGAACCTAG	-	rs138161802	byFrequency	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr5:159344616_159344624delAGAACCTAG	ENST00000306675.3	+	1	827_835	c.704_712delAGAACCTAG	c.(703-714)aag>a	p.KNLE235del		NM_000679.3	NP_000670.1	P35368	ADA1B_HUMAN	adrenoceptor alpha 1B	235					cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	AGAACCACCAAGAACCTAGAGGCAGGAGT	0.512													50	23	---	---	---	---					
RP11-146I2.1	0	broad.mit.edu	37	6	15059048	15059049	+	RNA	INS	-	-	T			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:15059048_15059049insT	ENST00000437648.1	-	0	426																											aaataacattcttttttttttt	0.416													4	3	---	---	---	---					
PNPLA1	285848	broad.mit.edu	37	6	36260881	36260882	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr6:36260881_36260882insC	ENST00000394571.2	+	3	482_483	c.482_483insC	c.(481-483)accfs	p.T161fs	PNPLA1_ENST00000312917.5_Frame_Shift_Ins_p.T66fs|PNPLA1_ENST00000388715.3_Frame_Shift_Ins_p.T66fs	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	161	Patatin.				lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						TGTGGCCTCATCCCCCCGACTT	0.653													65	91	---	---	---	---					
HOXA11	3207	broad.mit.edu	37	7	27224167	27224169	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:27224167_27224169delGCC	ENST00000006015.3	-	1	666_668	c.595_597delGGC	c.(595-597)del	p.G199del	HOXA11-AS_ENST00000520360.1_RNA	NM_005523.5	NP_005514.1	P31270	HXA11_HUMAN	homeobox A11	199	Poly-Gly.				branching involved in ureteric bud morphogenesis|cartilage development involved in endochondral bone morphogenesis|developmental growth|dorsal/ventral pattern formation|mesodermal cell fate specification|positive regulation of cell development|positive regulation of chondrocyte differentiation	protein-DNA complex|transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	16						tctcccggcagccgccgccgccg	0.768			T	NUP98	CML								2	4	---	---	---	---					
LOC646762	646762	broad.mit.edu	37	7	29699825	29699826	+	RNA	DEL	TT	TT	-	rs142232912		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:29699825_29699826delTT	ENST00000426767.1	-	0	366					NR_024278.1																						ATTATTGACCTTTTTTTTTTCA	0.252													4	2	---	---	---	---					
LINC00972	100505913	broad.mit.edu	37	7	85057220	85057221	+	RNA	DEL	AG	AG	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr7:85057220_85057221delAG	ENST00000438065.1	+	0	137																											gtggctcagcagagagagagag	0.500													2	4	---	---	---	---					
CTD-2281E23.3	0	broad.mit.edu	37	8	1197070	1197070	+	RNA	DEL	T	T	-	rs66617915		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr8:1197070delT	ENST00000517950.1	-	0	311																											GATCAGTGTGTGGAGTGATGG	0.572													2	4	---	---	---	---					
PRRC2B	84726	broad.mit.edu	37	9	134353994	134353995	+	Frame_Shift_Ins	INS	-	-	CAGGC			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr9:134353994_134353995insCAGGC	ENST00000357304.4	+	17	4801_4802	c.4746_4747insCAGGC	c.(4744-4749)gaaggcfs	p.EG1582fs	PRRC2B_ENST00000458550.1_Frame_Shift_Ins_p.EG888fs|PRRC2B_ENST00000405995.1_Frame_Shift_Ins_p.EG888fs|PRRC2B_ENST00000372249.1_5'UTR	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	1582							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						GAAAGAAGGAGCAGGCCGTGCA	0.634											OREG0019562	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	26	---	---	---	---					
RAPGEF1	2889	broad.mit.edu	37	9	134503354	134503355	+	In_Frame_Ins	INS	-	-	GTG			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr9:134503354_134503355insGTG	ENST00000372195.1	-	9	1389_1390	c.1146_1147insCAC	c.(1144-1149)tcctct>tcCACctct	p.382_383SS>STS	RAPGEF1_ENST00000372189.3_In_Frame_Ins_p.365_366SS>STS|RAPGEF1_ENST00000372190.3_In_Frame_Ins_p.383_384SS>STS|RAPGEF1_ENST00000481260.1_5'UTR			Q13905	RPGF1_HUMAN	Rap guanine nucleotide exchange factor (GEF) 1	365					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	39		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		CTGTCCAGAGAGGACAGCTGCT	0.609													5	3	---	---	---	---					
LBX1-AS1	399806	broad.mit.edu	37	10	103012349	103012349	+	RNA	DEL	T	T	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr10:103012349delT	ENST00000434878.1	+	0	110																											GGGCCAGCCCTTTTTTTTTGC	0.537													2	4	---	---	---	---					
FOLH1B	219595	broad.mit.edu	37	11	89405323	89405326	+	RNA	DEL	TTTA	TTTA	-	rs34562444		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr11:89405323_89405326delTTTA	ENST00000532352.1	+	0	1114							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						aattatattgtttatttatttttg	0.230													8	16	---	---	---	---					
RP11-415I12.3	0	broad.mit.edu	37	12	64157309	64157309	+	RNA	DEL	G	G	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr12:64157309delG	ENST00000509615.2	-	0	238																											tcaggaggctggggcaagaag	0.493													2	4	---	---	---	---					
LOC642426	642426	broad.mit.edu	37	14	19408019	19408019	+	RNA	DEL	A	A	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr14:19408019delA	ENST00000548050.1	-	0	279					NR_046104.1																						CTGTGGAGCCAAAAAAAAAAT	0.393													4	6	---	---	---	---					
METTL3	56339	broad.mit.edu	37	14	21966419	21966422	+	Frame_Shift_Del	DEL	TAGA	TAGA	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr14:21966419_21966422delTAGA	ENST00000298717.4	-	11	1874_1877	c.1723_1726delTCTA	c.(1723-1728)aafs	p.SK575fs	TOX4_ENST00000405508.1_3'UTR|TOX4_ENST00000262709.3_3'UTR	NM_019852.3	NP_062826.2	Q86U44	MTA70_HUMAN	methyltransferase like 3	575					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		TTCTTAGGTTTAGAGATGATACCA	0.431													30	59	---	---	---	---					
NOVA1-AS1	387977	broad.mit.edu	37	14	27136271	27136273	+	RNA	DEL	ATC	ATC	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr14:27136271_27136273delATC	ENST00000552826.1	+	0	93																											accaaatcttatcaACCCCTTTA	0.443													3	3	---	---	---	---					
SRP54-AS1	100506157	broad.mit.edu	37	14	35448908	35448908	+	RNA	DEL	A	A	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr14:35448908delA	ENST00000556355.1	-	0	23				RP11-85K15.2_ENST00000555015.1_RNA|RP11-85K15.2_ENST00000554945.1_RNA																							aaaaCACAGGAAAAAAAAAAT	0.408													2	4	---	---	---	---					
LINC01579	283682	broad.mit.edu	37	15	94315788	94315789	+	RNA	INS	-	-	A	rs71861989	by1000genomes	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr15:94315788_94315789insA	ENST00000557481.2	-	0	540																											gactccttctcaaaaaaaaaag	0.485													2	4	---	---	---	---					
CTD-3037G24.3	0	broad.mit.edu	37	16	12686627	12686627	+	RNA	DEL	A	A	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr16:12686627delA	ENST00000564505.1	-	0	307																											aaagatggggaaaaaaacagc	0.418													2	4	---	---	---	---					
LIPE-AS1	100996307	broad.mit.edu	37	19	42904444	42904444	+	RNA	DEL	C	C	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr19:42904444delC	ENST00000594624.2	+	0	51				LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000593491.2_RNA	NR_073180.1																						TTCTGTCCATCCCCCAGTGTC	0.592													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11083900	11083900	+	RNA	DEL	A	A	-	rs146094339		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr21:11083900delA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTCCTAAGCTAAAAAAATACA	0.249													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11094409	11094409	+	RNA	DEL	C	C	-	rs61674188		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr21:11094409delC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCTTAGCATGCAAAAATTATT	0.274													5	2	---	---	---	---					
GGT3P	2679	broad.mit.edu	37	22	18771547	18771547	+	RNA	DEL	G	G	-	rs149629602		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr22:18771547delG	ENST00000412448.1	-	0	834																											TTTTTGttttgtttttttttt	0.433													4	3	---	---	---	---					
RP1-76B20.11	0	broad.mit.edu	37	22	30114711	30114711	+	RNA	DEL	C	C	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr22:30114711delC	ENST00000416352.1	-	0	312				RP1-76B20.11_ENST00000451180.1_RNA|RP1-76B20.12_ENST00000420180.1_RNA																							AAGTGCTGGGCCCAGGCTGAC	0.587													2	4	---	---	---	---					
ISX-AS1	101926957	broad.mit.edu	37	22	35393173	35393174	+	RNA	INS	-	-	GTGT	rs56007365	by1000genomes	TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr22:35393173_35393174insGTGT	ENST00000448318.4	-	0	1184																											TAGAAAAAGTCgtgtgtgtgtg	0.490													3	3	---	---	---	---					
LINC01399	104310353	broad.mit.edu	37	22	35612521	35612522	+	RNA	INS	-	-	AG			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr22:35612521_35612522insAG	ENST00000423311.1	-	0	59																											AAAAAAGGAAAAGAGAGAGAGA	0.441													2	4	---	---	---	---					
RP3-439F8.1	0	broad.mit.edu	37	22	46939020	46939021	+	RNA	DEL	TT	TT	-	rs71757891		TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chr22:46939020_46939021delTT	ENST00000426112.1	+	0	1440																											ATTACTGttctttttttttttt	0.460													2	4	---	---	---	---					
ASMTL-AS1	80161	broad.mit.edu	37	X	1521581	1521582	+	RNA	INS	-	-	CT			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:1521581_1521582insCT	ENST00000425740.2	+	0	415				ASMTL-AS1_ENST00000420411.2_RNA|ASMTL-AS1_ENST00000443929.1_RNA	NR_026711.1															cervix(1)|endometrium(2)|lung(1)	4						GCTTCCTTCCCCCTCCCAAAAT	0.604													2	4	---	---	---	---					
RP13-297E16.4	0	broad.mit.edu	37	X	1853964	1853977	+	RNA	DEL	CCTCCTTCTTTCCC	CCTCCTTCTTTCCC	-			TCGA-GN-A4U7-06A-21D-A32N-08	TCGA-GN-A4U7-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68d7e90f-431f-45ce-a216-eaa3527b3297	f75ef88d-f98a-4b1a-a71a-848f4d3fe5af	g.chrX:1853964_1853977delCCTCCTTCTTTCCC	ENST00000427886.1	+	0	387																											ttcttctcctcctccttctttccccctccttctt	0.528													3	4	---	---	---	---