Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GRK4	2868	broad.mit.edu	37	4	2990529	2990529	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:2990529C>T	ENST00000398052.4	+	3	567	c.224C>T	c.(223-225)cCc>cTc	p.P75L	GRK4_ENST00000398051.4_Missense_Mutation_p.P43L|GRK4_ENST00000504933.1_Missense_Mutation_p.P75L|GRK4_ENST00000345167.6_Missense_Mutation_p.P43L	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	75	N-terminal.|RGS.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GATACCAAACCCACTCTAAAG	0.413000													14	31					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179587430	179587430	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179587430T>A	ENST00000589042.1	-	76	22420	c.22196A>T	c.(22195-22197)aAt>aTt	p.N7399I	TTN_ENST00000591111.1_Missense_Mutation_p.N7082I|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.N6155I|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7082	Ig-like 56.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTATACTATTTTCTGCTTT	0.323000													19	53					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91631050	91631050	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:91631050A>G	ENST00000359028.2	+	9	2080	c.1855A>G	c.(1855-1857)Aag>Gag	p.K619E	AKAP9_ENST00000358100.2_Missense_Mutation_p.K619E|AKAP9_ENST00000356239.3_Missense_Mutation_p.K607E			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	619	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGAAAAAGAAAAGAATGCTGT	0.348000			T	BRAF	papillary thyroid								35	46					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140773521	140773521	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:140773521G>A	ENST00000371372.1	+	2	445	c.300G>A	c.(298-300)atG>atA	p.M100I	CACNA1B_ENST00000277549.5_5'UTR|RP11-188C12.3_ENST00000371390.1_RNA|CACNA1B_ENST00000371363.1_Missense_Mutation_p.M100I|CACNA1B_ENST00000277551.2_Missense_Mutation_p.M100I|CACNA1B_ENST00000371355.4_Missense_Mutation_p.M100I|CACNA1B_ENST00000371357.1_Missense_Mutation_p.M100I	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	100					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TCGAGTATATGATCCTGGCCA	0.637000													4	23					0	0	1	0	0
OR6C74	254783	broad.mit.edu	37	12	55641793	55641793	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:55641793C>T	ENST00000343870.4	+	1	812	c.722C>T	c.(721-723)tCc>tTc	p.S241F		NM_001005490.1	NP_001005490.1	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C, member 74	241					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	12						ACATGTTCTTCCCACATGGTG	0.378000													22	71					0	0	1	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86537805	86537805	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:86537805G>A	ENST00000450689.2	-	17	2599	c.2414C>T	c.(2413-2415)cCa>cTa	p.P805L	KIAA1324L_ENST00000416314.1_Missense_Mutation_p.P638L|KIAA1324L_ENST00000297222.6_Missense_Mutation_p.P565L|KIAA1324L_ENST00000444627.1_Missense_Mutation_p.P734L	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	805						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					TGTTGGAACTGGGAACATATC	0.284000													34	67					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3241070	3241070	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:3241070C>T	ENST00000217939.6	-	5	2810	c.2656G>A	c.(2656-2658)Gaa>Aaa	p.E886K		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	886						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TCAACAACTTCCTCCAGAGGT	0.478000													77	15					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137237241	137237241	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:137237241G>A	ENST00000453654.1	-	20	1660	c.1121C>T	c.(1120-1122)tCc>tTc	p.S374F	DGKI_ENST00000288490.5_Missense_Mutation_p.S674F|DGKI_ENST00000446122.1_Missense_Mutation_p.S674F|DGKI_ENST00000424189.2_Missense_Mutation_p.S674F			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	674	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						CATGGGGATGGATTTGTAAGT	0.527000													73	130					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17051876	17051876	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:17051876C>T	ENST00000418129.2	+	2	1125	c.660C>T	c.(658-660)ttC>ttT	p.F220F	PLCL2_ENST00000432376.1_Silent_p.F220F|PLCL2_ENST00000396755.2_Silent_p.F220F|PLCL2_ENST00000460467.1_Intron	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	346	PH.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						AAATTTATTTCCTTTTAGTTC	0.358000													27	33					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11561565	11561565	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:11561565C>T	ENST00000294484.6	+	2	654	c.516C>T	c.(514-516)ccC>ccT	p.P172P	PTCHD2_ENST00000389575.3_Silent_p.P172P	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	172					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CCCGAGCCCCCCGCGTCATCC	0.672000													19	18					0	0	1	0	0
RP11-85G18.6	0	broad.mit.edu	37	10	27535085	27535085	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:27535085C>T	ENST00000574842.1	+	0	255																											CTGTCCTCATCAGATGGGGAT	0.527000													29	1					0	0	1	0	0
IL17RC	84818	broad.mit.edu	37	3	9970142	9970142	+	Missense_Mutation	SNP	C	C	T	rs151311782		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:9970142C>T	ENST00000295981.3	+	11	1462	c.1244C>T	c.(1243-1245)cCg>cTg	p.P415L	IL17RC_ENST00000383812.4_Missense_Mutation_p.P329L|IL17RC_ENST00000455057.1_Missense_Mutation_p.P329L|IL17RC_ENST00000416074.2_Missense_Mutation_p.P200L|IL17RC_ENST00000498214.1_3'UTR|IL17RC_ENST00000413608.1_Missense_Mutation_p.P344L|IL17RC_ENST00000403601.3_Missense_Mutation_p.P344L	NM_153461.3	NP_703191.1	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C	415						integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						CTGGTCCCACCGCTTTCCTGG	0.672000													86	94					0	0	1	0	0
AAAS	8086	broad.mit.edu	37	12	53715136	53715136	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:53715136G>A	ENST00000209873.4	-	1	279	c.114C>T	c.(112-114)ttC>ttT	p.F38F	AAAS_ENST00000394384.3_Silent_p.F38F|AAAS_ENST00000550286.1_Intron|AAAS_ENST00000549983.1_Intron	NM_015665.5	NP_056480.1	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency, alacrimia	38					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	20						CCTGGCCCCGGAAGTCGGGGG	0.657000													94	55					0	0	1	0	0
RFX3	5991	broad.mit.edu	37	9	3271119	3271119	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:3271119C>T	ENST00000382004.3	-	11	1398		c.e11-1		RFX3_ENST00000302303.1_Splice_Site|RFX3_ENST00000358730.2_Splice_Site	NM_134428.1	NP_602304.1	P48380	RFX3_HUMAN	regulatory factor X, 3 (influences HLA class II expression)						cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(11)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		CCAATATTGCCTAAAAAACAA	0.378000													24	3					0	0	1	0	0
PRAMEF10	343071	broad.mit.edu	37	1	12954493	12954493	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:12954493G>A	ENST00000235347.4	-	3	869	c.790C>T	c.(790-792)Ctc>Ttc	p.L264F		NM_001039361.3	NP_001034450.2	O60809	PRA10_HUMAN	PRAME family member 10	264										NS(2)|breast(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TACAGGCAGAGGAATGGAGAG	0.463000													96	214					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40634293	40634293	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:40634293G>A	ENST00000298910.7	+	6	638	c.580G>A	c.(580-582)Gag>Aag	p.E194K	LRRK2_ENST00000343742.2_Missense_Mutation_p.E194K	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	194					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AGTCTCAGAGGAGCAACTGAC	0.279000													25	13					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072013	17072013	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:17072013G>A	ENST00000359963.3	-	1	1687	c.1428C>T	c.(1426-1428)ctC>ctT	p.L476L		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	476					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CACCCATTAGGAGGTTCCCAC	0.517000													75	210					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12409257	12409257	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:12409257C>T	ENST00000358136.3	+	46	9387	c.9257C>T	c.(9256-9258)tCg>tTg	p.S3086L	VPS13D_ENST00000356315.4_Missense_Mutation_p.S3061L	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3085					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCAGGGGATTCGTTTGCTGTG	0.502000													87	110					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68703904	68703904	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:68703904C>T	ENST00000255078.3	+	13	2067	c.1956C>T	c.(1954-1956)tcC>tcT	p.S652S		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	652					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			AAAACTATTCCCATGAGAACT	0.567000													84	84					0	0	1	0	0
INHBC	3626	broad.mit.edu	37	12	57828922	57828922	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:57828922G>A	ENST00000309668.2	+	1	380	c.253G>A	c.(253-255)Ggg>Agg	p.G85R	INHBC_ENST00000550133.1_Missense_Mutation_p.G85R	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	85					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						GGTCCCACAGGGGGCACTTCT	0.572000													26	23					0	0	1	0	0
ENPP4	22875	broad.mit.edu	37	6	46108835	46108835	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:46108835G>A	ENST00000321037.4	+	3	1103	c.873G>A	c.(871-873)atG>atA	p.M291I		NM_014936.4	NP_055751.1	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)	291						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	18						GCCCTCATATGAATGTTTATC	0.328000													16	48					0	0	1	0	0
PLXDC1	57125	broad.mit.edu	37	17	37265599	37265599	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:37265599C>T	ENST00000315392.4	-	3	512	c.301G>A	c.(301-303)Gag>Aag	p.E101K	PLXDC1_ENST00000394316.2_Missense_Mutation_p.E101K|PLXDC1_ENST00000539608.1_Missense_Mutation_p.E28K|PLXDC1_ENST00000444911.2_Missense_Mutation_p.E61K|PLXDC1_ENST00000493200.1_5'UTR	NM_020405.4	NP_065138.2	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1	101					angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						CTGTGGGGCTCGCTGGGGCCA	0.592000													11	8					0	0	1	0	0
LMOD1	25802	broad.mit.edu	37	1	201868521	201868521	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:201868521G>A	ENST00000367288.4	-	2	1866	c.1620C>T	c.(1618-1620)ccC>ccT	p.P540P	RP11-307B6.3_ENST00000458139.1_RNA|RP11-307B6.3_ENST00000414927.1_RNA	NM_012134.2	NP_036266.2	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	540					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						GTGGAGCCAAGGGAGGGGGAG	0.562000													26	18					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107911735	107911735	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:107911735G>A	ENST00000328300.6	+	41	4034		c.e41+1		COL4A5_ENST00000361603.2_Splice_Site	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5						axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GGGAGACCAGGTATGTCCGTG	0.527000									Alport syndrome with Diffuse Leiomyomatosis				21	2					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82764371	82764371	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:82764371G>A	ENST00000423517.2	-	3	2832	c.2495C>T	c.(2494-2496)tCa>tTa	p.S832L	PCLO_ENST00000333891.8_Missense_Mutation_p.S832L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	778	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ACCAGGATGTGAAATAATTTT	0.428000													87	115					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228461502	228461502	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:228461502C>T	ENST00000570156.2	+	22	6368	c.6294C>T	c.(6292-6294)tgC>tgT	p.C2098C	OBSCN_ENST00000359599.6_Silent_p.C570C|RP5-1139B12.2_ENST00000602517.1_RNA|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000284548.11_Silent_p.C1723C|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000422127.1_Silent_p.C1723C	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1079	Ig-like 21.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGAGACCCTGCCGCAGGGAGC	0.632000													10	21					0	0	1	0	0
PALM	5064	broad.mit.edu	37	19	727599	727599	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:727599G>A	ENST00000264560.7	+	4	368	c.174G>A	c.(172-174)ggG>ggA	p.G58G	PALM_ENST00000606643.1_3'UTR|PALM_ENST00000338448.5_Silent_p.G58G	NM_001040134.1	NP_001035224.1	O75781	PALM_HUMAN	paralemmin	58					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane				endometrium(2)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		TGCTGGAGGGGACGCCGTCCT	0.647000													3	3					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	142012201	142012201	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:142012201G>A	ENST00000389484.3	-	4	1324	c.353C>T	c.(352-354)tCc>tTc	p.S118F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	118	EGF-like 1.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGGCAATTGGATAACAGTTC	0.313000										TSP Lung(27;0.18)			20	15					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109518558	109518558	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:109518558C>T	ENST00000356711.2	+	12	1453	c.1327C>T	c.(1327-1329)Cca>Tca	p.P443S	MYO16_ENST00000357550.2_Missense_Mutation_p.P443S|MYO16_ENST00000251041.5_Missense_Mutation_p.P443S	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	443	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GCTTGTTAACCCATACAAGGA	0.299000													36	99					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107041553	107041553	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:107041553T>A	ENST00000409886.3	-	20	2957	c.2870A>T	c.(2869-2871)aAg>aTg	p.K957M	RGPD3_ENST00000304514.7_Missense_Mutation_p.K957M	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	957					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						ACCACGGCCCTTCTTCCGGCC	0.403000													124	459					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10435066	10435066	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:10435066C>T	ENST00000245503.5	-	22	2965	c.2581G>A	c.(2581-2583)Gaa>Aaa	p.E861K	MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.E861K	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	861					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.?(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TTCTGAAATTCTTCCTTCATG	0.423000													54	72					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26164451	26164451	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:26164451G>A	ENST00000335473.7	+	4	818	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	MYO18B_ENST00000407587.2_Missense_Mutation_p.E190K|MYO18B_ENST00000536101.1_Missense_Mutation_p.E190K	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	190						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TACTGGAAAGGAAAAGAAAGG	0.617000													10	10					0	0	1	0	0
CCDC105	126402	broad.mit.edu	37	19	15132481	15132481	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:15132481G>A	ENST00000292574.3	+	5	1177	c.1095G>A	c.(1093-1095)acG>acA	p.T365T		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	365					microtubule cytoskeleton organization	microtubule		p.T365T(1)		NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						TCCGGTGTACGAAATATAACC	0.592000													23	32					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8737811	8737811	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:8737811G>A	ENST00000378641.3	+	24	3117	c.2642G>A	c.(2641-2643)aGc>aAc	p.S881N	PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000378637.2_Missense_Mutation_p.S881N|PLCB1_ENST00000338037.6_Missense_Mutation_p.S881N	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	881					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						GCTCTCCACAGCCAGCCAGCT	0.557000													29	66					0	0	1	0	0
TAS2R9	50835	broad.mit.edu	37	12	10961801	10961801	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:10961801C>T	ENST00000240691.2	-	1	966	c.874G>A	c.(874-876)Gct>Act	p.A292T		NM_023917.2	NP_076406.1	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	292					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TTCAGAAAAGCTTCCCTCAAC	0.368000													38	42					0	0	1	0	0
OR51G1	79324	broad.mit.edu	37	11	4944991	4944991	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:4944991G>A	ENST00000321961.2	-	1	646	c.579C>T	c.(577-579)agC>agT	p.S193S	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	193					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGACAATGATGCTAGAGCAGG	0.532000													20	37					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534247	92534247	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:92534247T>A	ENST00000298047.6	+	9	8085	c.8068T>A	c.(8068-8070)Tcc>Acc	p.S2690T	FAT3_ENST00000525166.1_Missense_Mutation_p.S2540T|FAT3_ENST00000409404.2_Missense_Mutation_p.S2690T			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2690	Cadherin 24.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGTAAAGCACTCCCTCATTCC	0.453000										TCGA Ovarian(4;0.039)			16	20					0	0	1	0	0
ADA	100	broad.mit.edu	37	20	43251686	43251686	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:43251686G>A	ENST00000372874.4	-	7	774	c.640C>T	c.(640-642)Cac>Tac	p.H214Y	ADA_ENST00000537820.1_Intron|PKIG_ENST00000372882.3_Intron|ADA_ENST00000464097.1_5'UTR|PKIG_ENST00000372887.1_Intron	NM_000022.2	NP_000013.2	P00813	ADA_HUMAN	adenosine deaminase	214					adenosine catabolic process|cell adhesion|hypoxanthine salvage|inosine biosynthetic process|negative regulation of adenosine receptor signaling pathway|purine nucleotide salvage|purine ribonucleoside monophosphate biosynthetic process|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation	cell junction|cytoplasmic membrane-bounded vesicle lumen|cytosol|external side of plasma membrane|lysosome	adenosine deaminase activity|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|pancreas(2)|prostate(3)|skin(2)|urinary_tract(1)	18		all_lung(126;1.24e-07)|Lung NSC(126;1.94e-07)|Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)		Adenosine(DB00640)|Cladribine(DB00242)|Dipyridamole(DB00975)|Erythromycin(DB00199)|Fludarabine(DB01073)|Idoxuridine(DB00249)|Nelarabine(DB01280)|Pentostatin(DB00552)|Theophylline(DB00277)|Vidarabine(DB00194)	TCCCCGGCGTGGACAGTACGG	0.652000									Adenosine Deaminase Deficiency				42	65					0	0	1	0	0
ZNF225	7768	broad.mit.edu	37	19	44635578	44635578	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:44635578C>T	ENST00000262894.6	+	5	1091	c.811C>T	c.(811-813)Cat>Tat	p.H271Y	ZNF225_ENST00000590612.1_Missense_Mutation_p.H271Y|ZNF225_ENST00000592780.1_3'UTR	NM_013362.2	NP_037494.2	Q9UK10	ZN225_HUMAN	zinc finger protein 225	271					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	16		Prostate(69;0.0352)|all_neural(266;0.202)				GGCCTTCATTCATGATTCCCA	0.398000													47	64					0	0	1	0	0
SLC32A1	140679	broad.mit.edu	37	20	37357136	37357136	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:37357136C>T	ENST00000217420.1	+	2	1695	c.1432C>T	c.(1432-1434)Ctg>Ttg	p.L478L		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	478					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CCTCTTTCACCTGCGCCTGCT	0.637000													41	37					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2901625	2901625	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:2901625C>T	ENST00000254695.8	+	14	1245	c.1155C>T	c.(1153-1155)atC>atT	p.I385I	RAP1GAP2_ENST00000366401.4_Silent_p.I370I|RAP1GAP2_ENST00000542807.1_Silent_p.I385I|RAP1GAP2_ENST00000540393.2_Silent_p.I366I	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	385	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						ATGCCTACATCGTCGTGCAGG	0.532000													49	56					0	0	1	0	0
MAP2K1	5604	broad.mit.edu	37	15	66729162	66729162	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:66729162C>T	ENST00000307102.5	+	3	901	c.370C>T	c.(370-372)Ccg>Tcg	p.P124S		NM_002755.3	NP_002746.1	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	124	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.P124S(8)		endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(8)|urinary_tract(1)	20						GTGCAACTCTCCGTACATCGT	0.507000													38	66					0	0	1	0	0
SPOCK1	6695	broad.mit.edu	37	5	136403404	136403404	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:136403404C>T	ENST00000394945.1	-	6	758	c.589_splice	c.e6+1	p.A197_splice	SPOCK1_ENST00000282223.7_Splice_Site_p.A197_splice	NM_004598.3	NP_004589.1	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	197					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CCTCACTCACCACTCCTTTCT	0.572000													12	44					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94931059	94931059	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:94931059G>A	ENST00000337425.5	-	4	1163	c.1089C>T	c.(1087-1089)tcC>tcT	p.S363S	SERPINA9_ENST00000424550.2_Silent_p.S214S|RP11-349I1.2_ENST00000536735.1_RNA|SERPINA9_ENST00000380365.3_Silent_p.S345S|SERPINA9_ENST00000448305.2_Silent_p.S265S|SERPINA9_ENST00000298845.7_Silent_p.S263S|SERPINA9_ENST00000546329.1_Silent_p.S327S	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	345					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		AAACCTGCAGGGAGTCTCTCT	0.398000													22	58					0	0	1	0	0
ADAD2	161931	broad.mit.edu	37	16	84224979	84224979	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:84224979C>T	ENST00000268624.3	+	1	236	c.143C>T	c.(142-144)gCg>gTg	p.A48V	ADAD2_ENST00000567413.1_3'UTR|ADAD2_ENST00000315906.5_Missense_Mutation_p.A48V	NM_139174.3	NP_631913.3	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2	48					RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(1)	13						cccgcgcccgcgcccgcgACG	0.761000													6	12					0	0	1	0	0
IFNAR1	3454	broad.mit.edu	37	21	34721728	34721728	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:34721728C>T	ENST00000270139.3	+	8	1174	c.1022C>T	c.(1021-1023)tCc>tTc	p.S341F	IFNAR1_ENST00000416947.2_Missense_Mutation_p.S272F|IFNAR1_ENST00000442357.2_Missense_Mutation_p.S341F	NM_000629.2	NP_000620.2	P17181	INAR1_HUMAN	interferon (alpha, beta and omega) receptor 1	341	Fibronectin type-III 3.				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|skin(2)	14					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	AACATTAGATCCCTTAGTGAT	0.328000													30	3					0	0	1	0	0
USP44	84101	broad.mit.edu	37	12	95926702	95926702	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:95926702G>A	ENST00000258499.3	-	2	1619	c.1331C>T	c.(1330-1332)aCc>aTc	p.T444I	USP44_ENST00000393091.2_Missense_Mutation_p.T444I|USP44_ENST00000552440.1_Missense_Mutation_p.T444I|USP44_ENST00000537435.2_Missense_Mutation_p.T444I	NM_001278393.1|NM_032147.2	NP_001265322.1|NP_115523.2	Q9H0E7	UBP44_HUMAN	ubiquitin specific peptidase 44	444					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(5)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	36						TGGTAAACTGGTACCAGTTGT	0.383000													31	30					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70460345	70460345	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:70460345C>T	ENST00000503640.1	-	5	1209	c.1154G>A	c.(1153-1155)gGa>gAa	p.G385E	UGT2A1_ENST00000514019.1_Missense_Mutation_p.G551E|UGT2A1_ENST00000502343.1_5'UTR|UGT2A1_ENST00000512704.1_Missense_Mutation_p.G341E|UGT2A1_ENST00000286604.4_Missense_Mutation_p.G385E|UGT2A2_ENST00000457664.2_Missense_Mutation_p.G394E	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	385					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						CATAGGGACTCCGTGGTAAAT	0.458000													39	31					0	0	1	0	0
SELENBP1	8991	broad.mit.edu	37	1	151338846	151338846	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:151338846G>A	ENST00000435071.1	-	7	1018	c.556C>T	c.(556-558)Ccc>Tcc	p.P186S	SELENBP1_ENST00000447402.3_Missense_Mutation_p.P188S|SELENBP1_ENST00000368868.5_Missense_Mutation_p.P250S|SELENBP1_ENST00000426705.2_Missense_Mutation_p.P292S			Q13228	SBP1_HUMAN	selenium binding protein 1	250					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|urinary_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ATCTCCAAGGGAATAAGCCCA	0.572000													89	116					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35604865	35604865	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:35604865C>T	ENST00000542713.1	-	3	333	c.176G>A	c.(175-177)gGa>gAa	p.G59E	FKBP5_ENST00000540787.1_Intron|FKBP5_ENST00000357266.4_Missense_Mutation_p.G59E|FKBP5_ENST00000539068.1_Missense_Mutation_p.G59E|FKBP5_ENST00000536438.1_Missense_Mutation_p.G59E	NM_001145777.1	NP_001139249.1	Q13451	FKBP5_HUMAN	FK506 binding protein 5	59	PPIase FKBP-type 1.				protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|urinary_tract(2)	17						TGACAATTTTCCTTTGTAATG	0.358000													15	52					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576582	158576582	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:158576582G>A	ENST00000361284.1	+	1	354	c.354G>A	c.(352-354)atG>atA	p.M118I		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					TGGCTGCCATGGGCTTTGACA	0.552000													73	94					0	0	1	0	0
ZBTB21	49854	broad.mit.edu	37	21	43413314	43413314	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:43413314T>C	ENST00000310826.5	-	3	1074	c.891A>G	c.(889-891)aaA>aaG	p.K297K	ZBTB21_ENST00000465968.1_Intron|ZBTB21_ENST00000398505.3_Silent_p.K297K|ZBTB21_ENST00000398499.1_Silent_p.K297K|ZBTB21_ENST00000398511.3_Silent_p.K297K	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		GACCATTTCCTTTGTTAGTTT	0.413000													67	9					0	0	1	0	0
MEIS3	56917	broad.mit.edu	37	19	47910346	47910346	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:47910346G>A	ENST00000331559.5	-	10	1512	c.1071C>T	c.(1069-1071)tcC>tcT	p.S357S	MEIS3_ENST00000558555.1_Silent_p.S328S|MEIS3_ENST00000561293.1_Silent_p.S374S|MEIS3_ENST00000559524.1_Silent_p.S374S|MEIS3_ENST00000561096.1_Silent_p.S416S|MEIS3_ENST00000560253.1_5'UTR|MEIS3_ENST00000441740.2_Silent_p.S311S	NM_020160.2	NP_064545.1	Q99687	MEIS3_HUMAN	Meis homeobox 3	328				VRPPG -> FRAPA (in Ref. 5).		nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(5)|lung(11)|prostate(1)|skin(2)	20		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		CTGTGCGGTTGGATTGATCGA	0.612000													11	16					0	0	1	0	0
TRBV19	28568	broad.mit.edu	37	7	142326947	142326947	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:142326947G>A	ENST00000390393.3	+	0	453																											ATAGCTGAAGGGTACAGCGTC	0.483000													94	120					0	0	1	0	0
ALOX5	240	broad.mit.edu	37	10	45941061	45941061	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:45941061G>A	ENST00000374391.2	+	14	2004	c.1951G>A	c.(1951-1953)Gag>Aag	p.E651K	ALOX5_ENST00000542434.1_Missense_Mutation_p.E594K|RP11-67C2.2_ENST00000435635.1_RNA	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	651	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	CGTGATTGCTGAGCGCAACAA	0.537000													57	12					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2921491	2921491	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:2921491C>T	ENST00000254695.8	+	18	1721	c.1632_splice	c.e18+1	p.S544_splice	RAP1GAP2_ENST00000366401.4_Splice_Site_p.S529_splice|RAP1GAP2_ENST00000542807.1_Splice_Site_p.S544_splice|RAP1GAP2_ENST00000540393.2_Splice_Site_p.S525_splice	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	544					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						ACCACCTTCTCGGTGAGTGCT	0.677000													8	4					0	0	1	0	0
EIF4B	1975	broad.mit.edu	37	12	53412708	53412708	+	Missense_Mutation	SNP	C	C	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:53412708C>G	ENST00000262056.9	+	3	604	c.278C>G	c.(277-279)tCg>tGg	p.S93W	RP11-983P16.4_ENST00000552905.1_RNA|EIF4B_ENST00000551527.1_3'UTR|EIF4B_ENST00000420463.3_Missense_Mutation_p.S93W|EIF4B_ENST00000416762.3_Missense_Mutation_p.S93W|RP11-983P16.4_ENST00000549388.1_RNA	NM_001417.4	NP_001408.2	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	93					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)	22						CTTCCCAAATCGCCACCCTAC	0.478000													40	26					0	0	1	0	0
FKBP15	23307	broad.mit.edu	37	9	115946090	115946090	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:115946090C>T	ENST00000238256.3	-	18	1869	c.1752G>A	c.(1750-1752)aaG>aaA	p.K584K		NM_015258.1	NP_056073.1	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	584					endocytosis|protein folding	axon|early endosome	actin binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(9)|ovary(3)|urinary_tract(1)	26						TCCGATTGCTCTTTTCAAGGA	0.378000													55	6					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037944	75037944	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:75037944T>A	ENST00000326665.5	-	14	3668	c.3450A>T	c.(3448-3450)aaA>aaT	p.K1150N	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1150	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CCACTGTCTCTTTTAGTGAAT	0.473000													39	59					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46125833	46125833	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:46125833C>T	ENST00000295452.4	-	1	265	c.98G>A	c.(97-99)gGa>gAa	p.G33E		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	33					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TCACCAGTTTCCCAAATGCAG	0.408000													19	21					0	0	1	0	0
DDX6	1656	broad.mit.edu	37	11	118656856	118656856	+	Silent	SNP	G	G	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:118656856G>C	ENST00000264018.4	-	2	410	c.105C>G	c.(103-105)ggC>ggG	p.G35G	DDX6_ENST00000534980.1_Silent_p.G35G|DDX6_ENST00000526070.2_Silent_p.G35G	NM_004397.4	NP_004388.2	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 6	35					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	13	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		GTGTCTGTGTGCCCCCTCCTC	0.507000			T	IGH@	B-NHL								54	69					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64597720	64597720	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:64597720G>A	ENST00000342711.5	-	29	3312	c.3313C>T	c.(3313-3315)Cga>Tga	p.R1105*		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1105	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						AGCGCAAGTCGATCctggtct	0.612000													16	11					0	0	1	0	0
OR11A1	26531	broad.mit.edu	37	6	29395011	29395011	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:29395011C>T	ENST00000377149.1	-	5	880	c.408G>A	c.(406-408)ctG>ctA	p.L136L	OR5V1_ENST00000377154.1_Intron|OR11A1_ENST00000377147.2_Silent_p.L136L|OR11A1_ENST00000377148.1_Silent_p.L136L			Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A, member 1	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|large_intestine(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	19						TGGGCCCCATCAGGAGTGGGT	0.562000													15	65					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51612879	51612879	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:51612879G>A	ENST00000371117.3	-	58	9810	c.9535C>T	c.(9535-9537)Ctt>Ttt	p.L3179F	PKHD1_ENST00000340994.4_Missense_Mutation_p.L3179F	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3179					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					ACTGCCAAAAGACCAATAGTA	0.408000													78	110					0	0	1	0	0
SNAPC4	6621	broad.mit.edu	37	9	139290163	139290163	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:139290163G>A	ENST00000298532.2	-	3	605	c.237C>T	c.(235-237)ctC>ctT	p.L79L		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	79					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GGTCTTCAGGGAGGGTTTTAT	0.567000													183	22					0	0	1	0	0
ALDH9A1	223	broad.mit.edu	37	1	165638528	165638528	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:165638528G>A	ENST00000354775.4	-	7	1394	c.1090C>T	c.(1090-1092)Ctt>Ttt	p.L364F	ALDH9A1_ENST00000538148.1_Missense_Mutation_p.L270F	NM_000696.3	NP_000687.3	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9 family, member A1	340					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	21	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	ACAAACCCAAGGACTCGCTCC	0.478000													51	86					0	0	1	0	0
GMEB1	10691	broad.mit.edu	37	1	29040709	29040709	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:29040709C>T	ENST00000373816.1	+	10	1254	c.1116C>T	c.(1114-1116)ctC>ctT	p.L372L	GMEB1_ENST00000480454.1_3'UTR|GMEB1_ENST00000361872.4_Silent_p.L372L|GMEB1_ENST00000294409.2_Silent_p.L382L	NM_024482.2	NP_077808.1	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding protein 1	382					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)	11		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCCCGGCTCCAGCGGCCAG	0.557000													58	67					0	0	1	0	0
ASAP2	8853	broad.mit.edu	37	2	9543450	9543450	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:9543450T>C	ENST00000281419.3	+	28	3355	c.3015T>C	c.(3013-3015)gcT>gcC	p.A1005A	ASAP2_ENST00000315273.4_Silent_p.A960A	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	1005	SH3.				regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						ACTTTATCGCTGACTGAATTG	0.403000													24	31					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7707643	7707643	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:7707643C>T	ENST00000572933.1	+	59	10502	c.9042C>T	c.(9040-9042)atC>atT	p.I3014I	DNAH2_ENST00000389173.2_Silent_p.I3014I			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3014	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGTTCAAGATCGACGAAACTA	0.532000													19	6					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435445	158435445	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:158435445C>T	ENST00000289451.2	+	1	174	c.94C>T	c.(94-96)Ctg>Ttg	p.L32L		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					TGTTATCTTCCTGCTCCTCTA	0.517000													46	67					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114186994	114186994	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:114186994C>T	ENST00000393081.1	+	21	2237	c.1930C>T	c.(1930-1932)Cat>Tat	p.H644Y	ACSL5_ENST00000433418.1_Missense_Mutation_p.H620Y|ACSL5_ENST00000369410.3_Missense_Mutation_p.H426Y|ACSL5_ENST00000354273.4_Missense_Mutation_p.H644Y|ACSL5_ENST00000356116.1_Missense_Mutation_p.H700Y|ACSL5_ENST00000354655.4_Missense_Mutation_p.H644Y	NM_203380.1	NP_976314.1	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	644					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		CATTTTTCTTCATCCAGAGCC	0.448000													46	11					0	0	1	0	0
USP42	84132	broad.mit.edu	37	7	6183809	6183809	+	Silent	SNP	C	C	T	rs151011297	by1000genomes	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:6183809C>T	ENST00000306177.5	+	9	1130	c.972C>T	c.(970-972)acC>acT	p.T324T		NM_032172.2	NP_115548.1	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	324					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity	p.T324T(1)|p.T452T(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(2)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	35		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		CAAATTTTACCGGTGGAAAAA	0.368000													11	16					0	0	1	0	0
SLC4A1	6521	broad.mit.edu	37	17	42337855	42337855	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:42337855T>C	ENST00000262418.6	-	6	557	c.402A>G	c.(400-402)caA>caG	p.Q134Q	AC003043.1_ENST00000597382.1_Intron|SLC4A1_ENST00000471005.1_5'UTR	NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1	134					bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	40		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TGTCTAGCAGTTGGTTGGCCA	0.612000													22	20					0	0	1	0	0
RGL2	5863	broad.mit.edu	37	6	33263448	33263448	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:33263448G>A	ENST00000497454.1	-	7	1352	c.857C>T	c.(856-858)tCt>tTt	p.S286F	RGL2_ENST00000437840.2_5'UTR|PFDN6_ENST00000463584.1_Intron|RGL2_ENST00000444031.2_Missense_Mutation_p.S204F	NM_001243738.1|NM_004761.4	NP_001230667.1|NP_004752.1	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation stimulator-like 2	286	Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			breast(2)|cervix(2)|endometrium(7)|kidney(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	34						AGCTCGGACAGATGGGCAGAG	0.572000													18	68					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141215150	141215150	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:141215150C>T	ENST00000389484.3	-	61	10667	c.9696G>A	c.(9694-9696)ggG>ggA	p.G3232G		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3232					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACTTGGTTTTCCCATCAGTCC	0.428000										TSP Lung(27;0.18)			50	78					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41719668	41719668	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:41719668C>T	ENST00000400454.1	-	6	1616	c.1139G>A	c.(1138-1140)gGg>gAg	p.G380E		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	380	Ig-like C2-type 4.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GTATGCGCCCCCGTCACTTTT	0.507000													203	34					0	0	1	0	0
CHD1L	9557	broad.mit.edu	37	1	146759368	146759368	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:146759368C>T	ENST00000369258.4	+	19	2296	c.2276C>T	c.(2275-2277)tCc>tTc	p.S759F	CHD1L_ENST00000361293.5_Missense_Mutation_p.S478F|CHD1L_ENST00000369259.3_Missense_Mutation_p.S555F|CHD1L_ENST00000431239.1_Missense_Mutation_p.S665F|CHD1L_ENST00000467213.1_3'UTR	NM_001256336.1|NM_004284.4|NM_024568.2	NP_001243265.1|NP_004275.4|NP_078844.2	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein 1-like	759	Macro.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(15)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(923;0.0487)					GAAAAGCGATCCGCTGAGCCA	0.443000													20	26					0	0	1	0	0
TSR1	55720	broad.mit.edu	37	17	2237874	2237874	+	Silent	SNP	G	G	A	rs141850371	by1000genomes	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:2237874G>A	ENST00000301364.4	-	5	1952	c.873C>T	c.(871-873)atC>atT	p.I291I		NM_018128.4	NP_060598.3	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)	291					ribosome assembly	nucleolus	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	20						CATATCCAACGATATGCAGCA	0.438000													100	99					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28723666	28723666	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:28723666G>A	ENST00000257197.3	-	8	1289	c.1028C>T	c.(1027-1029)tCa>tTa	p.S343L	DSC1_ENST00000257198.5_Missense_Mutation_p.S343L|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	343	Cadherin 2.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ATCCTCAAGTGAAATAGTAAT	0.338000													21	38					0	0	1	0	0
PRSS54	221191	broad.mit.edu	37	16	58318621	58318621	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:58318621C>T	ENST00000219301.4	-	6	921	c.527G>A	c.(526-528)gGa>gAa	p.G176E	PRSS54_ENST00000567164.1_Missense_Mutation_p.G176E|PRSS54_ENST00000563336.1_5'UTR|PRSS54_ENST00000543437.1_Missense_Mutation_p.G77E	NM_001080492.1	NP_001073961.1	Q6PEW0	PRS54_HUMAN	protease, serine, 54	176	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						CATGTGATTTCCTGTCTGGAC	0.478000													26	45					0	0	1	0	0
ZNF728	388523	broad.mit.edu	37	19	23159540	23159540	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:23159540G>A	ENST00000594710.1	-	4	744	c.599C>T	c.(598-600)tCc>tTc	p.S200F		NM_001267716.1	NP_001254645.1			zinc finger protein 728																		ACTTTTGTAGGAATTCTCTCT	0.348000													21	19					0	0	1	0	0
MORC2	22880	broad.mit.edu	37	22	31330144	31330144	+	Missense_Mutation	SNP	G	G	A	rs142840638		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:31330144G>A	ENST00000215862.4	-	21	3405	c.2042C>T	c.(2041-2043)tCt>tTt	p.S681F	MORC2_ENST00000397641.2_Missense_Mutation_p.S743F	NM_014941.1	NP_055756.1	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	743							ATP binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	21						TTCCTCATCAGAAACTGCGAC	0.537000													29	98					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34003369	34003369	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:34003369G>A	ENST00000382491.3	-	28	4641	c.4517C>T	c.(4516-4518)cCa>cTa	p.P1506L	SYNJ1_ENST00000382499.2_3'UTR|SYNJ1_ENST00000357345.3_3'UTR|SYNJ1_ENST00000322229.7_Missense_Mutation_p.P1553L|SYNJ1_ENST00000433931.2_Missense_Mutation_p.P1592L	NM_001160306.1	NP_001153778.1	O43426	SYNJ1_HUMAN	synaptojanin 1	1553	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						AGGATCTACTGGAGGGCTGGT	0.512000													34	7					0	0	1	0	0
OR4C11	219429	broad.mit.edu	37	11	55371373	55371373	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:55371373G>A	ENST00000302231.4	-	1	501	c.477C>T	c.(475-477)atC>atT	p.I159I		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	159					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						TTAAGGCCAGGATAATCTGAG	0.453000													44	56					0	0	1	0	0
TGM1	7051	broad.mit.edu	37	14	24730947	24730947	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:24730947G>A	ENST00000206765.6	-	3	585	c.462C>T	c.(460-462)tcC>tcT	p.S154S	TGM1_ENST00000544573.1_Intron	NM_000359.2	NP_000350.1	P22735	TGM1_HUMAN	transglutaminase 1	154					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)	24				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	CATAGGTCCGGGACAGGAGGA	0.587000													71	53					0	0	1	0	0
PATZ1	23598	broad.mit.edu	37	22	31738934	31738934	+	Missense_Mutation	SNP	C	C	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:31738934C>G	ENST00000266269.5	-	2	1913	c.1284G>C	c.(1282-1284)ttG>ttC	p.L428F	PATZ1_ENST00000351933.4_Missense_Mutation_p.L428F|PATZ1_ENST00000405309.3_Missense_Mutation_p.L428F|PATZ1_ENST00000215919.3_Missense_Mutation_p.L428F	NM_014323.2	NP_055138.2	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	428					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	12						TATGTCCGTTCAAGTGATCAG	0.527000													44	122					0	0	1	0	0
OGN	4969	broad.mit.edu	37	9	95165590	95165590	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:95165590C>T	ENST00000262551.4	-	2	520	c.100G>A	c.(100-102)Gga>Aga	p.G34R	CENPP_ENST00000375587.3_Intron|OGN_ENST00000375561.5_Missense_Mutation_p.G34R	NM_033014.2	NP_148935.1	P20774	MIME_HUMAN	osteoglycin	34						extracellular space|proteinaceous extracellular matrix	growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	13						TTATCTGTTCCATAATCATAG	0.363000													25	3					0	0	1	0	0
WDR63	126820	broad.mit.edu	37	1	85573801	85573801	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:85573801C>T	ENST00000294664.6	+	15	1819	c.1639C>T	c.(1639-1641)Cct>Tct	p.P547S	WDR63_ENST00000370596.1_Missense_Mutation_p.P508S|WDR63_ENST00000326813.8_Missense_Mutation_p.P508S	NM_145172.3	NP_660155.2	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	547										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)	36				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		TATTGAAATTCCTTTTGATGT	0.358000													38	53					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168105435	168105435	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:168105435G>A	ENST00000409195.1	+	9	7622	c.7533G>A	c.(7531-7533)agG>agA	p.R2511R	XIRP2_ENST00000295237.9_Silent_p.R2511R|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Silent_p.R2289R	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2336					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CAGCACCCAGGAAAAAACAGA	0.358000													87	59					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10399321	10399321	+	Silent	SNP	G	G	A	rs145122906		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:10399321G>A	ENST00000226207.5	-	35	5209	c.5115C>T	c.(5113-5115)atC>atT	p.I1705I	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1705						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity	p.I1705I(1)		NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CCTGTTCTGCGATTTTCCTGC	0.532000													53	56					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43625862	43625862	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:43625862C>T	ENST00000586348.1	+	0	45																											ATGGTAAGTCCCAGGTCCAAA	0.493000													64	190					0	0	1	0	0
WDHD1	11169	broad.mit.edu	37	14	55457990	55457990	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:55457990G>A	ENST00000360586.3	-	12	1347	c.1282C>T	c.(1282-1284)Ccc>Tcc	p.P428S	WDHD1_ENST00000420358.2_Missense_Mutation_p.P305S|WDHD1_ENST00000421192.1_Missense_Mutation_p.P305S|WDHD1_ENST00000359167.4_Silent_p.L7L	NM_007086.3	NP_009017.1	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	428						cytoplasm|nucleoplasm	DNA binding			breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(2)	42						TTTTGCCGGGGAGTTGGCATG	0.443000													33	20					0	0	1	0	0
NCAPG	64151	broad.mit.edu	37	4	17839386	17839386	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:17839386G>A	ENST00000251496.2	+	16	2604	c.2428G>A	c.(2428-2430)Gga>Aga	p.G810R		NM_022346.3	NP_071741.2	Q9BPX3	CND3_HUMAN	non-SMC condensin I complex, subunit G	810					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	27				STAD - Stomach adenocarcinoma(129;0.18)		AAGACCAAGTGGATTAAATCC	0.413000													72	86					0	0	1	0	0
PLA2G15	23659	broad.mit.edu	37	16	68289777	68289777	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:68289777C>T	ENST00000219345.5	+	5	694	c.611C>T	c.(610-612)aCg>aTg	p.T204M	PLA2G15_ENST00000444212.2_Intron|PLA2G15_ENST00000413021.2_Intron|PLA2G15_ENST00000566188.1_Intron	NM_012320.3	NP_036452.1	Q8NCC3	PAG15_HUMAN	phospholipase A2, group XV	204					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			kidney(2)|large_intestine(2)|lung(2)|ovary(2)|prostate(3)|skin(1)	12						AACATGTACACGCTCTACTTT	0.637000													40	32					0	0	1	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186919851	186919851	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:186919851G>A	ENST00000367466.3	+	13	1479	c.1327G>A	c.(1327-1329)Gaa>Aaa	p.E443K	PLA2G4A_ENST00000442353.2_Missense_Mutation_p.E383K	NM_024420.2	NP_077734.1	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	443	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity	p.E443K(2)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	TGAATCACACGAACCCAAAGG	0.393000													23	36					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62199887	62199887	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:62199887C>T	ENST00000467148.1	-	5	1623	c.1554G>A	c.(1552-1554)aaG>aaA	p.K518K	RP4-697K14.12_ENST00000454223.1_RNA	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		CCAGCTCCTGCTTGCGGTTGC	0.687000													11	10					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92533040	92533040	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:92533040C>T	ENST00000298047.6	+	9	6878	c.6861C>T	c.(6859-6861)ttC>ttT	p.F2287F	FAT3_ENST00000525166.1_Silent_p.F2137F|FAT3_ENST00000409404.2_Silent_p.F2287F			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2287	Cadherin 20.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCCCTATTTTCGATCAGCCTA	0.413000										TCGA Ovarian(4;0.039)			11	13					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9019631	9019631	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:9019631G>A	ENST00000397910.4	-	22	37718	c.37515C>T	c.(37513-37515)ttC>ttT	p.F12505F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12507					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCCGATGGGTGAAACCTGCAT	0.502000													31	52					0	0	1	0	0
DGCR2	9993	broad.mit.edu	37	22	19048382	19048382	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:19048382G>A	ENST00000545799.1	-	6	903	c.703C>T	c.(703-705)Cgt>Tgt	p.R235C	DGCR2_ENST00000473832.1_Intron|DGCR2_ENST00000537045.1_Intron|DGCR2_ENST00000263196.7_Intron			P98153	IDD_HUMAN	DiGeorge syndrome critical region gene 2	0	C-type lectin.				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)	18	Colorectal(54;0.0993)					CTGCGGAAACGAGCTCCCAAC	0.587000													17	14					0	0	1	0	0
CCR6	1235	broad.mit.edu	37	6	167550575	167550575	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:167550575G>A	ENST00000341935.5	+	3	1409	c.857G>A	c.(856-858)cGa>cAa	p.R286Q	CCR6_ENST00000400926.2_Missense_Mutation_p.R286Q|CCR6_ENST00000349984.4_Missense_Mutation_p.R286Q	NM_031409.3	NP_113597.2	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	286					cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	14		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		AAAATGAACCGATCCTGCCAG	0.468000													33	78					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33246025	33246025	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:33246025A>G	ENST00000404816.2	+	3	968	c.615A>G	c.(613-615)caA>caG	p.Q205Q	LTBP1_ENST00000354476.3_Silent_p.Q205Q			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	205	EGF-like 1.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCCGGCCACAACTCTGTGTGT	0.522000													145	222					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104897710	104897710	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:104897710G>A	ENST00000507740.1	+	2	543	c.307G>A	c.(307-309)Gac>Aac	p.D103N	RIMS2_ENST00000406091.3_Missense_Mutation_p.D295N|RIMS2_ENST00000522174.1_3'UTR|RIMS2_ENST00000436393.2_Missense_Mutation_p.D73N|RIMS2_ENST00000262231.10_Missense_Mutation_p.D103N	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	326	RabBD.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AAGTTATAGGGACTCCAACAG	0.408000										HNSCC(12;0.0054)			51	73					0	0	1	0	0
INO80D	54891	broad.mit.edu	37	2	206869793	206869793	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:206869793G>A	ENST00000403263.1	-	11	2787	c.2383C>T	c.(2383-2385)Cag>Tag	p.Q795*		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	795					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						TGTGGCCTCTGGGAGGCATGG	0.562000													86	170					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82841443	82841443	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:82841443G>A	ENST00000265077.3	+	9	9918	c.9353G>A	c.(9352-9354)gGa>gAa	p.G3118E	VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Missense_Mutation_p.G377E|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000343200.5_Missense_Mutation_p.G2131E|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000342785.4_Missense_Mutation_p.G1364E|VCAN_ENST00000512590.2_Missense_Mutation_p.G1316E	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	3118	EGF-like 1.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TGTGTGCCAGGATACAGCGGA	0.463000													101	55					0	0	1	0	0
TSR3	115939	broad.mit.edu	37	16	1400846	1400846	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:1400846G>A	ENST00000007390.2	-	3	594	c.488C>T	c.(487-489)tCc>tTc	p.S163F		NM_001001410.2	NP_001001410.1			TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)																		TTCCACGCAGGAAAGTCTGTA	0.632000													19	46					0	0	1	0	0
SESTD1	91404	broad.mit.edu	37	2	180047865	180047865	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:180047865C>T	ENST00000428443.3	-	3	422	c.106G>A	c.(106-108)Gaa>Aaa	p.E36K	SESTD1_ENST00000486468.1_5'UTR	NM_178123.4	NP_835224.3	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	36	CRAL-TRIO.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding	p.E36K(1)		breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(3)	30			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			TTTGTCTGTTCGAGGCATAAT	0.358000													38	69					0	0	1	0	0
CA8	767	broad.mit.edu	37	8	61178537	61178537	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:61178537C>T	ENST00000317995.4	-	3	628	c.364G>A	c.(364-366)Gaa>Aaa	p.E122K		NM_004056.4	NP_004047.3	P35219	CAH8_HUMAN	carbonic anhydrase VIII	122					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding			endometrium(2)|large_intestine(5)|lung(6)|prostate(2)|skin(1)	16		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)				CGCTGGTTTTCTCTTCCCCAG	0.378000													31	45					0	0	1	0	0
PRPF4B	8899	broad.mit.edu	37	6	4031811	4031811	+	Silent	SNP	T	T	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:4031811T>G	ENST00000337659.6	+	2	160	c.60T>G	c.(58-60)tcT>tcG	p.S20S	PRPF4B_ENST00000538861.1_Silent_p.S6S	NM_003913.4	NP_003904.3	Q13523	PRP4B_HUMAN	pre-mRNA processing factor 4B	20						catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(3)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	22	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				ATGCTAATTCTGAAAAGAGTA	0.289000													18	60					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7769757	7769757	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:7769757G>A	ENST00000358415.4	+	11	1411	c.1245G>A	c.(1243-1245)ctG>ctA	p.L415L	ITIH2_ENST00000379587.4_Silent_p.L404L	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	415	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						CCGTCTCGCTGATCATTTTGG	0.453000													21	4					0	0	1	0	0
IGKV1D-42	28892	broad.mit.edu	37	2	90229387	90229387	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:90229387C>T	ENST00000390278.2	+	0	227																											CTAAGCTCTTCCTCTATGATG	0.502000													30	51					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057312	9057312	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:9057312G>A	ENST00000397910.4	-	3	30337	c.30134C>T	c.(30133-30135)tCc>tTc	p.S10045F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10047	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAAAGAGGAGGAAGGGATACT	0.468000													19	41					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54952773	54952773	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:54952773G>A	ENST00000273286.5	-	3	913	c.751C>T	c.(751-753)Cac>Tac	p.H251Y	CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000490478.1_Intron|LRTM1_ENST00000493075.1_Missense_Mutation_p.H175Y|CACNA2D3_ENST00000474759.1_Intron|CACNA2D3_ENST00000288197.5_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	251						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		ACCACACCGTGGGCAGAGCCG	0.632000													22	29					0	0	1	0	0
H2AFY2	55506	broad.mit.edu	37	10	71835472	71835472	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:71835472G>A	ENST00000373255.4	+	2	322	c.58G>A	c.(58-60)Ggt>Agt	p.G20S		NM_018649.2	NP_061119.1	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	20	Histone H2A.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(4)|skin(1)	15						AGCTAGGGCAGGTGTCATCTT	0.562000													30	8					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72049838	72049838	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:72049838C>T	ENST00000305425.4	-	9	2442	c.2020_splice	c.e9+1	p.D674_splice	DACH1_ENST00000313174.7_Splice_Site_p.D526_splice|DACH1_ENST00000359684.2_Splice_Site_p.D726_splice|DACH1_ENST00000354591.4_Splice_Site_p.D472_splice	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	724	DACHbox-C.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		ACCCTCTTACCATTTAAGACC	0.378000													196	114					0	0	1	0	0
KCNIP4	80333	broad.mit.edu	37	4	20852243	20852243	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:20852243C>T	ENST00000382148.3	-	2	472	c.136G>A	c.(136-138)Gaa>Aaa	p.E46K	KCNIP4_ENST00000382149.4_5'UTR|KCNIP4_ENST00000447367.2_Missense_Mutation_p.E37K|KCNIP4_ENST00000509207.1_Missense_Mutation_p.E9K|KCNIP4_ENST00000359001.5_Missense_Mutation_p.E9K|KCNIP4_ENST00000382150.4_Missense_Mutation_p.E50K|KCNIP4_ENST00000382152.2_Missense_Mutation_p.E71K	NM_001035003.1	NP_001030175.1	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	71						plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				TCAAGGGCTTCAGGCCGATGC	0.468000													36	43					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12626182	12626182	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:12626182C>T	ENST00000425538.1	+	5	472	c.272C>T	c.(271-273)tCc>tTc	p.S91F	MYOCD_ENST00000395988.1_5'UTR|MYOCD_ENST00000343344.4_Missense_Mutation_p.S91F	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	91					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GCAGAGAGGTCCATTCCAACT	0.443000													84	102					0	0	1	0	0
KRT7	3855	broad.mit.edu	37	12	52635399	52635399	+	Silent	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:52635399T>A	ENST00000331817.5	+	5	1020	c.837T>A	c.(835-837)gcT>gcA	p.A279A		NM_005556.3	NP_005547.3	P08729	K2C7_HUMAN	keratin 7	279	Coil 2.|Rod.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(357;0.105)		GGGCTGAGGCTGAAGCCTGGT	0.592000													15	62					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2604977	2604977	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:2604977C>T	ENST00000358864.1	+	17	2256	c.2241C>T	c.(2239-2241)ttC>ttT	p.F747F		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	747						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TCCCAACCTTCCTGGGCAAGA	0.498000													65	77					0	0	1	0	0
SLX4IP	128710	broad.mit.edu	37	20	10603512	10603512	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:10603512C>T	ENST00000334534.5	+	8	892	c.712C>T	c.(712-714)Caa>Taa	p.Q238*		NM_001009608.1	NP_001009608.1			SLX4 interacting protein																		GCTTCCTGTTCAAAAGCTGGA	0.517000													58	71					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7623135	7623135	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:7623135C>T	ENST00000572933.1	+	2	1543	c.83C>T	c.(82-84)gCt>gTt	p.A28V	DNAH2_ENST00000389173.2_Missense_Mutation_p.A28V|DNAH2_ENST00000082259.3_Missense_Mutation_p.A28V|DNAH2_ENST00000570791.1_Missense_Mutation_p.A28V			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	28	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCCACTCGGGCTGCTGTGGCC	0.637000													25	2					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20198969	20198969	+	Missense_Mutation	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:20198969C>A	ENST00000400331.5	-	5	1323	c.1015G>T	c.(1015-1017)Gac>Tac	p.D339Y	MACC1_ENST00000332878.4_Missense_Mutation_p.D339Y|MACC1_ENST00000589011.1_Missense_Mutation_p.D339Y	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	339					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						TGACTCAAGTCGATTAGCTTG	0.418000													28	39					8.58068e-18	8.67565e-18	1	1	0
ZFP14	57677	broad.mit.edu	37	19	36831434	36831434	+	Missense_Mutation	SNP	C	C	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:36831434C>G	ENST00000270001.7	-	5	1409	c.1294G>C	c.(1294-1296)Gcc>Ccc	p.A432P		NM_020917.2	NP_065968.1	Q9HCL3	ZFP14_HUMAN	ZFP14 zinc finger protein	432					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	26	Esophageal squamous(110;0.162)					AGTCTAAAGGCCTTTCCACAC	0.398000													50	62					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179484609	179484609	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179484609G>A	ENST00000589042.1	-	250	46659	c.46435C>T	c.(46435-46437)Cct>Tct	p.P15479S	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P13838S|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P6539S|TTN_ENST00000342992.6_Missense_Mutation_p.P12911S|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P6414S|TTN-AS1_ENST00000604956.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P6606S|TTN-AS1_ENST00000589487.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13838	Fibronectin type-III 12.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTCAACAGGAATTTCTGGA	0.308000													65	36					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169312701	169312701	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:169312701T>C	ENST00000511577.1	-	29	4152	c.3905A>G	c.(3904-3906)aAt>aGt	p.N1302S	DDX60L_ENST00000505890.1_Missense_Mutation_p.N1303S|DDX60L_ENST00000260184.7_Missense_Mutation_p.N1302S			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1302	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CTGTCTGTAATTTAAAGCATC	0.433000													10	12					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735698	55735698	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:55735698C>T	ENST00000312345.2	-	1	292	c.242G>A	c.(241-243)gGa>gAa	p.G81E		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	81					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G81E(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					AGAAATATTTCCTTTCTGAGT	0.383000													34	59					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28968918	28968918	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:28968918G>A	ENST00000359747.4	+	5	483	c.454G>A	c.(454-456)Gat>Aat	p.D152N	DSG4_ENST00000308128.4_Missense_Mutation_p.D152N|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	152	Cadherin 1.		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GGACATAAATGATAACGCTCC	0.408000													63	92					0	0	1	0	0
PRG2	5553	broad.mit.edu	37	11	57156634	57156634	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:57156634C>T	ENST00000311862.5	-	3	288	c.215G>A	c.(214-216)gGg>gAg	p.G72E	RP11-872D17.8_ENST00000529411.1_Missense_Mutation_p.G177E|PRG2_ENST00000533605.1_Missense_Mutation_p.G72E|PRG2_ENST00000525955.1_Missense_Mutation_p.G72E	NM_001243245.1|NM_002728.4	NP_001230174.1|NP_002719.3			proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)											central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCAACAGCCCCATCTTTCTT	0.552000													54	77					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25439026	25439026	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:25439026C>T	ENST00000255324.5	+	29	4043	c.3991C>T	c.(3991-3993)Cca>Tca	p.P1331S	RNF17_ENST00000381921.1_Intron|RNF17_ENST00000339524.3_Intron	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1331					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		ACCTAAAAATCCATGGGAGAA	0.289000													41	121					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47849990	47849990	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:47849990G>A	ENST00000359568.5	+	36	7864	c.7757G>A	c.(7756-7758)aGt>aAt	p.S2586N	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2586					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					AAGACGCTGAGTGAAGAGCAA	0.517000													5	47					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123785911	123785911	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:123785911C>T	ENST00000422452.2	-	8	1495	c.1432G>A	c.(1432-1434)Gat>Aat	p.D478N	TENM1_ENST00000371130.3_Missense_Mutation_p.D478N	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TGCTGTGTATCATCAGAGCCC	0.433000													40	5					0	0	1	0	0
COL8A2	1296	broad.mit.edu	37	1	36563663	36563663	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:36563663C>T	ENST00000397799.1	-	4	1843	c.1619G>A	c.(1618-1620)gGc>gAc	p.G540D	COL8A2_ENST00000481785.1_Missense_Mutation_p.G475D|COL8A2_ENST00000303143.4_Missense_Mutation_p.G540D			P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2	540	Nonhelical region (NC1).				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			NS(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCCTGCGATGCCAGTCTCATC	0.736000													9	16					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142186798	142186798	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:142186798G>A	ENST00000519811.1	+	15	2714	c.2644G>A	c.(2644-2646)Gac>Aac	p.D882N	DENND3_ENST00000262585.2_Missense_Mutation_p.D802N|DENND3_ENST00000424248.1_Missense_Mutation_p.D750N			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	802										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			AACCGAGTGTGACCTTTGGCA	0.522000													71	92					0	0	1	0	0
SERPINB7	8710	broad.mit.edu	37	18	61449714	61449714	+	Silent	SNP	C	C	T	rs145018483		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:61449714C>T	ENST00000398019.2	+	2	433	c.108C>T	c.(106-108)ttC>ttT	p.F36F	SERPINB7_ENST00000540675.1_Silent_p.F36F|SERPINB7_ENST00000336429.2_Silent_p.F36F|SERPINB7_ENST00000546027.1_Silent_p.F36F	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	36					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				TGAGCCTCTTCGCTGCCCTGG	0.488000													31	6					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143018840	143018840	+	Missense_Mutation	SNP	C	C	T	rs143506735		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:143018840C>T	ENST00000343257.2	+	5	682	c.595C>T	c.(595-597)Cgt>Tgt	p.R199C	CLCN1_ENST00000495612.1_3'UTR	NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	199					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GACAATACTTCGTGGGGTTGT	0.507000													19	33					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156747707	156747707	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:156747707G>A	ENST00000347377.6	+	15	1999	c.1568G>A	c.(1567-1569)gGg>gAg	p.G523E	CYFIP2_ENST00000318218.6_Missense_Mutation_p.G523E|CYFIP2_ENST00000377576.3_Missense_Mutation_p.G523E|CYFIP2_ENST00000521420.1_Missense_Mutation_p.G497E|CYFIP2_ENST00000541131.1_Missense_Mutation_p.G448E|CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000435847.2_Missense_Mutation_p.G197E|CYFIP2_ENST00000522463.1_Missense_Mutation_p.G327E	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	523					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGGAGGGAGGGCGAGAGCCC	0.552000													16	34					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123848091	123848091	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:123848091C>T	ENST00000531945.1	-	1	397	c.308G>A	c.(307-309)gGg>gAg	p.G103E		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	103					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GATCACCTTCCCATCCAGAGT	0.547000													13	20					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71101260	71101260	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:71101260C>T	ENST00000393567.2	-	15	2158	c.2008G>A	c.(2008-2010)Gag>Aag	p.E670K	HYDIN_ENST00000288168.10_Missense_Mutation_p.E687K|HYDIN_ENST00000541601.1_Missense_Mutation_p.E687K|HYDIN_ENST00000538248.1_Missense_Mutation_p.E697K|HYDIN_ENST00000448691.1_Missense_Mutation_p.E670K|HYDIN_ENST00000448089.2_Missense_Mutation_p.E670K|HYDIN_ENST00000393550.2_Missense_Mutation_p.E685K|HYDIN_ENST00000321489.5_Missense_Mutation_p.E670K	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	670										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AGTGCCAGCTCGTATTTCTGC	0.527000													25	32					0	0	1	0	0
AMIGO1	57463	broad.mit.edu	37	1	110051176	110051176	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:110051176T>C	ENST00000369864.4	-	2	708	c.359A>G	c.(358-360)aAc>aGc	p.N120S	AMIGO1_ENST00000369862.1_Missense_Mutation_p.N120S			Q86WK6	AMGO1_HUMAN	adhesion molecule with Ig-like domain 1	120					axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		ACGCAGCTGGTTGGAGGAGAG	0.577000													35	48					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108214074	108214074	+	Silent	SNP	C	C	T	rs71855130		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:108214074C>T	ENST00000278616.4	+	57	8779	c.8394C>T	c.(8392-8394)gcC>gcT	p.A2798A	C11orf65_ENST00000525729.1_Intron|ATM_ENST00000452508.2_Silent_p.A2798A|C11orf65_ENST00000526725.1_Intron	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2798	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATTTCAGTGCCTTTCAGTGCC	0.368000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			46	64					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160257130	160257130	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:160257130G>A	ENST00000392783.2	-	17	3373	c.2878C>T	c.(2878-2880)Cga>Tga	p.R960*	AC008277.1_ENST00000420020.1_RNA|AC008277.1_ENST00000594921.1_RNA|BAZ2B_ENST00000343439.5_Nonsense_Mutation_p.R860*|BAZ2B_ENST00000392782.1_Nonsense_Mutation_p.R924*|BAZ2B_ENST00000355831.2_Nonsense_Mutation_p.R926*	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	960	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						TGCTGAGCTCGAAGTTCTTTT	0.264000													15	27					0	0	1	0	0
C15orf59	388135	broad.mit.edu	37	15	74032661	74032661	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:74032661G>A	ENST00000569673.1	-	3	1683	c.479C>T	c.(478-480)tCc>tTc	p.S160F	C15orf59_ENST00000379822.4_Missense_Mutation_p.S160F|C15orf59_ENST00000558834.1_5'UTR			Q2T9L4	CO059_HUMAN	chromosome 15 open reading frame 59	160										breast(1)|endometrium(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CTCCTCACTGGAGGAGTCTGG	0.667000													50	42					0	0	1	0	0
POU5F2	134187	broad.mit.edu	37	5	93076785	93076785	+	Missense_Mutation	SNP	G	G	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:93076785G>C	ENST00000510627.4	-	1	558	c.485C>G	c.(484-486)aCg>aGg	p.T162R	POU5F2_ENST00000606183.1_5'UTR|FAM172A_ENST00000395965.3_Intron|FAM172A_ENST00000509163.1_Intron|FAM172A_ENST00000509739.1_Intron|FAM172A_ENST00000505869.1_Intron	NM_153216.1	NP_694948.1	Q8N7G0	PO5F2_HUMAN	POU domain class 5, transcription factor 2	162	POU-specific.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity						all_cancers(142;3.87e-05)|all_epithelial(76;4.59e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0415)|all cancers(79;2.03e-19)		GCAGATGGTCGTCTGGCTAAG	0.577000													17	15					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66950205	66950205	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:66950205C>T	ENST00000299752.4	-	4	450	c.257G>A	c.(256-258)cGa>cAa	p.R86Q	CDH16_ENST00000570262.1_Intron|CDH16_ENST00000394055.3_Missense_Mutation_p.R86Q|CDH16_ENST00000565796.1_Missense_Mutation_p.R86Q|CDH16_ENST00000568632.1_Missense_Mutation_p.R86Q	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	86	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R86Q(1)		endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CTGCTCCTCTCGGTCCAGGGC	0.622000													20	31					0	0	1	0	0
ZNF263	10127	broad.mit.edu	37	16	3340184	3340184	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:3340184C>T	ENST00000219069.5	+	6	2554	c.1678C>T	c.(1678-1680)Ccc>Tcc	p.P560S	ZNF263_ENST00000538765.1_Missense_Mutation_p.P208S	NM_005741.4	NP_005732.2	O14978	ZN263_HUMAN	zinc finger protein 263	560					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(4)|urinary_tract(3)	20						TGACAGCACCCCCTTTCTTAC	0.498000													31	26					0	0	1	0	0
AZI1	22994	broad.mit.edu	37	17	79181018	79181018	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:79181018G>A	ENST00000269392.4	-	4	541	c.294C>T	c.(292-294)ttC>ttT	p.F98F	AZI1_ENST00000374782.3_Silent_p.F98F|AZI1_ENST00000450824.2_Silent_p.F98F|AZI1_ENST00000575907.1_Silent_p.F98F	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	98					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			AGAGCATCAGGAAGTCTGTGG	0.632000													20	38					0	0	1	0	0
PPEF1	5475	broad.mit.edu	37	X	18842119	18842119	+	Missense_Mutation	SNP	C	C	T	rs142716113		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:18842119C>T	ENST00000361511.4	+	17	2074	c.1580C>T	c.(1579-1581)tCg>tTg	p.S527L	PPEF1_ENST00000349874.5_Missense_Mutation_p.S465L|PPEF1_ENST00000544635.1_Missense_Mutation_p.S462L|PPEF1_ENST00000359763.6_Missense_Mutation_p.S474L|PPEF1_ENST00000543630.1_3'UTR	NM_006240.2|NM_152224.1	NP_006231.2|NP_689410.1	O14829	PPE1_HUMAN	protein phosphatase, EF-hand calcium binding domain 1	527					detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	43	Hepatocellular(33;0.183)					TCCCTCAGTTCGAATCTGGTA	0.413000													80	9					0	0	1	0	0
SOX30	11063	broad.mit.edu	37	5	157078188	157078188	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:157078188G>A	ENST00000265007.6	-	1	1240	c.899C>T	c.(898-900)tCc>tTc	p.S300F	SOX30_ENST00000519442.1_Intron|SOX30_ENST00000311371.5_Missense_Mutation_p.S300F	NM_178424.1	NP_848511.1	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30	300					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	23	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTCCAGTAGGGACTGCATTTT	0.537000													79	59					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411405	126411405	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:126411405G>A	ENST00000394329.3	+	17	13441	c.13428G>A	c.(13426-13428)ggG>ggA	p.G4476G	FAT4_ENST00000335110.5_Silent_p.G2717G	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4476					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GTCCTCAGGGGAAGGTGTGCA	0.612000													68	81					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92436196	92436196	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:92436196G>A	ENST00000267622.4	-	21	6134	c.5761C>T	c.(5761-5763)Ccg>Tcg	p.P1921S		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1921					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		GCCAAAAACGGATTTACATCT	0.433000			T	PDGFRB	AML								22	12					0	0	1	0	0
DPPA3P2	400206	broad.mit.edu	37	14	36841013	36841013	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:36841013C>T	ENST00000557188.1	+	0	644																											TTCAAATGTCCCTGCAGTTTC	0.433000													29	105					0	0	1	0	0
ATP13A2	23400	broad.mit.edu	37	1	17313584	17313584	+	Missense_Mutation	SNP	C	C	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:17313584C>G	ENST00000452699.1	-	26	3214	c.3025G>C	c.(3025-3027)Ggc>Cgc	p.G1009R	RP1-37C10.3_ENST00000446261.1_RNA|ATP13A2_ENST00000341676.5_Missense_Mutation_p.G970R|ATP13A2_ENST00000326735.8_Missense_Mutation_p.G1014R	NM_001141973.1|NM_022089.2	NP_001135445.1|NP_071372.1	Q9NQ11	AT132_HUMAN	ATPase type 13A2	1014					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		AGCTGCACGCCGGTCACCAGG	0.706000													31	32					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947151	237947151	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:237947151G>A	ENST00000366574.2	+	90	12456	c.12139G>A	c.(12139-12141)Gac>Aac	p.D4047N	RYR2_ENST00000360064.6_Missense_Mutation_p.D4053N|RYR2_ENST00000542537.1_Missense_Mutation_p.D4031N	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4047	EF-hand.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTCCAAGAGGGACTTCCACAA	0.423000													16	24					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112666712	112666712	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:112666712G>A	ENST00000308611.3	-	2	391	c.127C>T	c.(127-129)Cat>Tat	p.H43Y	CD200R1_ENST00000490004.1_Intron|CD200R1_ENST00000440122.2_Missense_Mutation_p.H43Y|CD200R1_ENST00000295863.4_Intron|CD200R1_ENST00000471858.1_Intron	NM_138806.3	NP_620161.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	22					interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						CCTAAAGCATGATTCTCCTTG	0.378000													27	24					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22172955	22172955	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:22172955G>A	ENST00000374695.3	-	63	8381	c.8302C>T	c.(8302-8304)Ccc>Tcc	p.P2768S	HSPG2_ENST00000430507.1_3'UTR	NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	2768	Ig-like C2-type 13.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGGTGACTGGGGAGGCTGCCC	0.657000													52	65					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73043595	73043595	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:73043595C>T	ENST00000604411.1	+	0	31556				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						AGTACACTGCCTTATATTAGT	0.378000													61	8					0	0	1	0	0
C2orf57	165100	broad.mit.edu	37	2	232458657	232458657	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:232458657C>T	ENST00000313965.2	+	1	1083	c.995C>T	c.(994-996)cCc>cTc	p.P332L		NM_152614.2	NP_689827.2	Q53QW1	CB057_HUMAN	chromosome 2 open reading frame 57	332										endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|pancreas(1)|prostate(4)|skin(2)	19		Renal(207;0.025)|all_hematologic(139;0.0735)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;1.33e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)		CGCTCGGTCCCCAGCCTGGTG	0.662000													58	118					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123848214	123848214	+	Missense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:123848214A>T	ENST00000531945.1	-	1	274	c.185T>A	c.(184-186)gTg>gAg	p.V62E		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GTCAGAGCCCACAGTTAGGAG	0.527000													14	20					0	0	1	0	0
SLC35F2	54733	broad.mit.edu	37	11	107686522	107686522	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:107686522G>A	ENST00000525071.1	-	5	868	c.280C>T	c.(280-282)Cga>Tga	p.R94*	SLC35F2_ENST00000525815.1_Nonsense_Mutation_p.R94*|SLC35F2_ENST00000429869.1_Nonsense_Mutation_p.R94*|SLC35F2_ENST00000375682.4_Nonsense_Mutation_p.R47*|SLC35F2_ENST00000265836.7_Intron			Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	94					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		ATACCTGATCGAAATGCCAGC	0.338000													58	81					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126320065	126320065	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:126320065G>A	ENST00000394329.3	+	2	5315	c.5302G>A	c.(5302-5304)Gat>Aat	p.D1768N	FAT4_ENST00000335110.5_Missense_Mutation_p.D66N	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1768	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CATGGATGCTGATGAGGTAGC	0.408000													59	92					0	0	1	0	0
PHLDB1	23187	broad.mit.edu	37	11	118499304	118499304	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:118499304C>T	ENST00000361417.2	+	7	2176	c.1765C>T	c.(1765-1767)Ctc>Ttc	p.L589F	PHLDB1_ENST00000356063.5_Missense_Mutation_p.L589F	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	589										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		TGAGGACGACCTCCTGGAGTA	0.622000													17	22					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216251618	216251618	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:216251618C>T	ENST00000354785.4	-	28	4775	c.4406G>A	c.(4405-4407)tGg>tAg	p.W1469*	FN1_ENST00000357009.2_Nonsense_Mutation_p.W1378*|FN1_ENST00000446046.1_Nonsense_Mutation_p.W1378*|FN1_ENST00000443816.1_Nonsense_Mutation_p.W1378*|FN1_ENST00000432072.2_Nonsense_Mutation_p.W1469*|FN1_ENST00000336916.4_Nonsense_Mutation_p.W1378*|FN1_ENST00000421182.1_Nonsense_Mutation_p.W1378*|FN1_ENST00000323926.6_Nonsense_Mutation_p.W1469*|FN1_ENST00000359671.1_Nonsense_Mutation_p.W1378*|FN1_ENST00000357867.4_Nonsense_Mutation_p.W1378*|FN1_ENST00000356005.4_Nonsense_Mutation_p.W1378*|FN1_ENST00000346544.3_Nonsense_Mutation_p.W1378*|FN1_ENST00000345488.5_Nonsense_Mutation_p.W1378*			P02751	FINC_HUMAN	fibronectin 1	1468	Cell-attachment.|Fibronectin type-III 10.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGAGCAATCCAGTGCACAGT	0.512000													31	18					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50827043	50827043	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:50827043G>A	ENST00000376959.2	-	2	1330	c.1167C>T	c.(1165-1167)atC>atT	p.I389I	KCNC3_ENST00000474951.1_Intron|KCNC3_ENST00000391818.2_Intron|KCNC3_ENST00000477616.1_Silent_p.I389I			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	389					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		AGAAGGGCAGGATGGCCACAC	0.592000													25	38					0	0	1	0	0
NOL9	79707	broad.mit.edu	37	1	6589100	6589100	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:6589100C>T	ENST00000377705.5	-	10	1811	c.1779G>A	c.(1777-1779)ggG>ggA	p.G593G		NM_024654.4	NP_078930.3	Q5SY16	NOL9_HUMAN	nucleolar protein 9	593					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(2)|urinary_tract(1)	19	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGGATGGGCCCATTCGTGT	0.493000													19	38					0	0	1	0	0
GAS2	2620	broad.mit.edu	37	11	22747949	22747949	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:22747949G>A	ENST00000454584.2	+	4	684	c.379G>A	c.(379-381)Gaa>Aaa	p.E127K	GAS2_ENST00000278187.3_Missense_Mutation_p.E127K|GAS2_ENST00000433790.1_Missense_Mutation_p.E127K	NM_001143830.1	NP_001137302.1	O43903	GAS2_HUMAN	growth arrest-specific 2	127	CH.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(4)|stomach(1)	24						AGGGGTGGATGAAACGTGTCT	0.403000													57	63					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22817077	22817077	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:22817077T>C	ENST00000404138.1	+	3	1147	c.636T>C	c.(634-636)gcT>gcC	p.A212A	ZBTB40_ENST00000374651.4_Silent_p.A212A|ZBTB40_ENST00000375647.4_Silent_p.A212A	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	212					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		CAGCTGAAGCTTGTTCCCCCT	0.483000													63	79					0	0	1	0	0
MCF2	4168	broad.mit.edu	37	X	138678842	138678842	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:138678842C>T	ENST00000520602.1	-	22	2608	c.2323G>A	c.(2323-2325)Gat>Aat	p.D775N	MCF2_ENST00000370576.4_Missense_Mutation_p.D715N|MCF2_ENST00000536274.1_Missense_Mutation_p.D676N|MCF2_ENST00000338585.6_Missense_Mutation_p.D731N|MCF2_ENST00000519895.1_Missense_Mutation_p.D791N|MCF2_ENST00000414978.1_Missense_Mutation_p.D775N|MCF2_ENST00000370578.4_Missense_Mutation_p.D860N|MCF2_ENST00000370573.4_Missense_Mutation_p.D715N			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	715	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					CTAGCCAAATCCTTCATTTTT	0.408000													62	10					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061119	9061119	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:9061119G>A	ENST00000397910.4	-	3	26530	c.26327C>T	c.(26326-26328)cCc>cTc	p.P8776L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8778	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CGTGGTGAGGGGAGTAGAAAT	0.498000													51	71					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179453325	179453325	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179453325C>T	ENST00000589042.1	-	304	63351	c.63127G>A	c.(63127-63129)Gaa>Aaa	p.E21043K	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E19402K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E12103K|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E18475K|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E11978K|TTN_ENST00000342175.6_Missense_Mutation_p.E12170K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19402	Fibronectin type-III 52.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTCCAATTTCATTTTCTGCC	0.448000													186	132					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	69407239	69407239	+	Silent	SNP	G	G	A	rs61735044	byFrequency	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:69407239G>A	ENST00000433211.1	-	2	207	c.33C>T	c.(31-33)atC>atT	p.I11I	CTNNA3_ENST00000373744.4_Silent_p.I11I|CTNNA3_ENST00000545309.1_Silent_p.I11I	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	11					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						CCTGAGGATCGATATTCAATG	0.378000													4	53					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47629501	47629501	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:47629501C>T	ENST00000546455.1	+	4	1386	c.655C>T	c.(655-657)Cgc>Tgc	p.R219C	PCED1B_ENST00000432328.1_Missense_Mutation_p.R219C					PC-esterase domain containing 1B																		TTTCCACTTCCGCCACGCGAG	0.602000													6	12					0	0	1	0	0
OR6N1	128372	broad.mit.edu	37	1	158735842	158735842	+	Missense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:158735842A>T	ENST00000335094.2	-	1	650	c.631T>A	c.(631-633)Ttc>Atc	p.F211I		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					ATCAGCAGGAAGGTGGCTAGG	0.493000													64	101					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070509	9070509	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:9070509G>A	ENST00000397910.4	-	3	17140	c.16937C>T	c.(16936-16938)tCc>tTc	p.S5646F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5648	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGATGTGGAGGAAACAGGAGA	0.517000													18	31					0	0	1	0	0
SHC4	399694	broad.mit.edu	37	15	49176513	49176513	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:49176513A>G	ENST00000332408.4	-	4	1200	c.772T>C	c.(772-774)Tca>Cca	p.S258P		NM_203349.3	NP_976224.3	Q6S5L8	SHC4_HUMAN	SHC (Src homology 2 domain containing) family, member 4	258	PID.				intracellular signal transduction	cell junction|postsynaptic membrane				breast(1)|endometrium(2)|large_intestine(8)|lung(11)|ovary(3)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	29		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TTCATTCCTGAAAACTGAAGA	0.323000													28	1					0	0	1	0	0
AMDHD1	144193	broad.mit.edu	37	12	96350637	96350637	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:96350637G>A	ENST00000266736.2	+	4	590	c.484G>A	c.(484-486)Gac>Aac	p.D162N		NM_152435.2	NP_689648.2	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	162					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|skin(1)	22						ATATGGCCTCGACCTGGAGAC	0.632000													36	84					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	42080539	42080539	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:42080539C>T	ENST00000400454.1	-	2	679	c.202G>A	c.(202-204)Gat>Aat	p.D68N		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	68	Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding	p.D68N(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CCGGGGACATCGTAGATCTCC	0.562000													4	100					0	0	1	0	0
ITGB3	3690	broad.mit.edu	37	17	45376805	45376805	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:45376805G>A	ENST00000559488.1	+	11	1838	c.1822G>A	c.(1822-1824)Gaa>Aaa	p.E608K	ITGB3_ENST00000560629.1_Silent_p.*596*|ITGB3_ENST00000435993.2_Missense_Mutation_p.E561K	NM_000212.2	NP_000203.2	P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	608	Cysteine-rich tandem repeats.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	CGGCAAGTGTGAATGTGGCAG	0.592000													71	99					0	0	1	0	0
CDC27	996	broad.mit.edu	37	17	45201287	45201287	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:45201287G>A	ENST00000066544.3	-	17	2293	c.2200C>T	c.(2200-2202)Ccc>Tcc	p.P734S	CDC27_ENST00000531206.1_Missense_Mutation_p.P740S|CDC27_ENST00000527547.1_Missense_Mutation_p.P733S|CDC27_ENST00000446365.2_Missense_Mutation_p.P673S	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	734					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						GATTCTTTGGGAACAATTTGT	0.328000													14	21					0	0	1	0	0
GABRG2	2566	broad.mit.edu	37	5	161576197	161576197	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:161576197G>A	ENST00000356592.3	+	8	1466	c.1006G>A	c.(1006-1008)Gat>Aat	p.D336N	GABRG2_ENST00000414552.2_Missense_Mutation_p.D376N|GABRG2_ENST00000361925.4_Missense_Mutation_p.D336N|GABRG2_ENST00000393933.4_Missense_Mutation_p.D241N	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	336					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CACAGCGATGGATCTCTTTGT	0.478000													70	40					0	0	1	0	0
FAM46B	115572	broad.mit.edu	37	1	27333152	27333152	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:27333152C>T	ENST00000289166.5	-	2	726	c.561G>A	c.(559-561)tgG>tgA	p.W187*		NM_052943.3	NP_443175.2	Q96A09	FA46B_HUMAN	family with sequence similarity 46, member B	187										breast(1)|central_nervous_system(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		AGATGAGGCTCCAGCGGTCCG	0.567000													77	105					0	0	1	0	0
MAP2K1	5604	broad.mit.edu	37	15	66729163	66729163	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:66729163C>T	ENST00000307102.5	+	3	902	c.371C>T	c.(370-372)cCg>cTg	p.P124L		NM_002755.3	NP_002746.1	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	124	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(8)|urinary_tract(1)	20						TGCAACTCTCCGTACATCGTG	0.512000													40	65					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121209082	121209082	+	Silent	SNP	C	C	T	rs149492812		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:121209082C>T	ENST00000297848.3	+	6	759	c.489C>T	c.(487-489)gtC>gtT	p.V163V	COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000537875.1_Silent_p.V163V|COL14A1_ENST00000247781.3_Silent_p.V163V|COL14A1_ENST00000309791.4_Silent_p.V163V	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	163	VWFA 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TAATCCTGGTCGATGGTTCAT	0.438000													102	141					0	0	1	0	0
IBSP	3381	broad.mit.edu	37	4	88732573	88732573	+	Silent	SNP	G	G	A	rs140447227	by1000genomes	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:88732573G>A	ENST00000226284.5	+	7	532	c.465G>A	c.(463-465)gaG>gaA	p.E155E		NM_004967.3	NP_004958.2	P21815	SIAL_HUMAN	integrin-binding sialoprotein	155	Asp/Glu-rich (acidic).|Poly-Glu.				biomineral tissue development|cell adhesion|ossification					breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)	21		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		aagaagaggaggaagaggaag	0.423000													22	27					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224473770	224473770	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:224473770G>A	ENST00000281701.6	-	15	2116	c.1857C>T	c.(1855-1857)ctC>ctT	p.L619L	NVL_ENST00000340871.4_Silent_p.L430L|NVL_ENST00000469075.1_Silent_p.L528L|NVL_ENST00000482491.1_Silent_p.L343L|NVL_ENST00000391875.2_Silent_p.L513L|NVL_ENST00000361463.3_Silent_p.L513L	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	619						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		GACCAGCAAGGAGGACCCCAG	0.453000													29	39					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067818	9067818	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:9067818G>A	ENST00000397910.4	-	3	19831	c.19628C>T	c.(19627-19629)tCa>tTa	p.S6543L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6545	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTGGGGAGTGAAGTCAGATG	0.498000													24	23					0	0	1	0	0
CELA3A	10136	broad.mit.edu	37	1	22332274	22332274	+	Missense_Mutation	SNP	C	C	T	rs147890009		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:22332274C>T	ENST00000290122.3	+	4	366	c.347C>T	c.(346-348)tCg>tTg	p.S116L	CELA3A_ENST00000374663.1_Missense_Mutation_p.S116L	NM_005747.4	NP_005738.4			chymotrypsin-like elastase family, member 3A											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TGGAACCGCTCGTGTGTGGCC	0.582000													68	93					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202348	248202348	+	Missense_Mutation	SNP	G	G	A	rs138166879		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:248202348G>A	ENST00000366479.2	+	1	875	c.779G>A	c.(778-780)cGt>cAt	p.R260H	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			ACCTATGTACGTCCAAGATCC	0.493000													52	10					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99130479	99130479	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:99130479G>A	ENST00000370992.4	-	22	2688	c.2577C>T	c.(2575-2577)atC>atT	p.I859I	RRP12_ENST00000414986.1_Silent_p.I798I|RRP12_ENST00000479481.1_5'UTR|RRP12_ENST00000315563.6_Silent_p.I759I|RRP12_ENST00000536831.1_Silent_p.I577I	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	859						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TCACCTCTGGGATGAGGGCAG	0.582000													46	13					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11071176	11071176	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:11071176C>T	ENST00000409790.1	+	8	1053	c.823C>T	c.(823-825)Ctc>Ttc	p.L275F	CLEC16A_ENST00000409552.3_Missense_Mutation_p.L273F	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	275										breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CTGTGAGTTCCTCAACGATGT	0.552000													28	27					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140281142	140281142	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:140281142C>T	ENST00000458420.3	+	13	2394	c.2204C>T	c.(2203-2205)tCc>tTc	p.S735F		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	735					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						GCAGGCTACTCCATCTACGGT	0.552000										HNSCC(16;0.037)			15	35					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151818912	151818912	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:151818912G>A	ENST00000535741.1	-	15	2456	c.1983C>T	c.(1981-1983)ttC>ttT	p.F661F	LRBA_ENST00000510413.1_Silent_p.F661F|LRBA_ENST00000507224.1_Silent_p.F661F|LRBA_ENST00000357115.3_Silent_p.F661F			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	661						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					ATTGCTTAATGAACATCAACA	0.318000													19	31					0	0	1	0	0
LDLRAD4	753	broad.mit.edu	37	18	13387740	13387740	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:13387740C>T	ENST00000361205.4	+	3	687	c.19C>T	c.(19-21)Cag>Tag	p.Q7*	LDLRAD4_ENST00000359446.5_Nonsense_Mutation_p.Q7*|LDLRAD4_ENST00000399848.3_Nonsense_Mutation_p.Q7*	NM_001276249.1|NM_181481.3	NP_001263178.1|NP_852146.1			low density lipoprotein receptor class A domain containing 4																		AGCTGGTTTTCAGGCCACAAA	0.582000													48	60					0	0	1	0	0
ZNF222	7673	broad.mit.edu	37	19	44536709	44536709	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:44536709C>T	ENST00000187879.8	+	4	1044	c.882C>T	c.(880-882)ttC>ttT	p.F294F	ZNF222_ENST00000391960.3_Silent_p.F334F|ZNF223_ENST00000591793.1_Intron	NM_013360.2	NP_037492.2	Q9UK12	ZN222_HUMAN	zinc finger protein 222	294					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	20		Prostate(69;0.0435)				GAAGAGGTTTCATTGATAGGC	0.383000													71	114					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51853752	51853752	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:51853752G>A	ENST00000453097.2	+	8	1090	c.873G>A	c.(871-873)atG>atA	p.M291I	SLC4A8_ENST00000358657.3_Missense_Mutation_p.M318I|SLC4A8_ENST00000535225.2_Missense_Mutation_p.M238I|SLC4A8_ENST00000514353.3_Missense_Mutation_p.M238I|SLC4A8_ENST00000394856.1_Missense_Mutation_p.M238I	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	291					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		TTCATTTCATGAAAAAAATTC	0.413000													38	108					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34006766	34006766	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:34006766C>T	ENST00000373381.4	-	59	9597	c.9421G>A	c.(9421-9423)Gac>Aac	p.D3141N		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3113	Sushi 25.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CATGTCCGGTCCTTGGTGCAG	0.498000													72	105					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30701292	30701292	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:30701292G>A	ENST00000256246.2	-	1	5316	c.5242C>T	c.(5242-5244)Caa>Taa	p.Q1748*		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1748										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AATCTTCCTTGGAAACCAGGA	0.353000													26	4					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516880	140516880	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:140516880G>A	ENST00000231134.5	+	1	2081	c.1864G>A	c.(1864-1866)Gag>Aag	p.E622K		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		622	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCACAATGGCGAGGTGCGCAC	0.706000													62	60					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211541835	211541835	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:211541835G>A	ENST00000233072.5	+	37	4575	c.4379G>A	c.(4378-4380)gGa>gAa	p.G1460E	CPS1_ENST00000451903.2_Missense_Mutation_p.G1009E|CPS1_ENST00000430249.2_Missense_Mutation_p.G1466E	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1460					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GTTGATAGTGGAATCCCTCTC	0.393000													129	65					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	75866276	75866276	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:75866276C>T	ENST00000377636.3	-	19	3794	c.3448G>A	c.(3448-3450)Gat>Aat	p.D1150N	TBC1D4_ENST00000425511.1_Missense_Mutation_p.D314N|TBC1D4_ENST00000431480.2_Missense_Mutation_p.D1142N|TBC1D4_ENST00000377625.2_Missense_Mutation_p.D1087N	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	1150						cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		GTATTCATATCAGGTAGCGTG	0.323000													55	22					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114284782	114284782	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:114284782C>T	ENST00000393500.3	+	14	1627	c.807C>T	c.(805-807)ggC>ggT	p.G269G	FOXP2_ENST00000360232.4_Silent_p.G344G|FOXP2_ENST00000393489.3_Silent_p.G252G|FOXP2_ENST00000408937.3_Silent_p.G369G|FOXP2_ENST00000378237.3_Silent_p.G344G|FOXP2_ENST00000393491.3_Silent_p.G252G|FOXP2_ENST00000403559.4_Silent_p.G361G|FOXP2_ENST00000393494.2_Silent_p.G344G|FOXP2_ENST00000350908.4_Silent_p.G344G|FOXP2_ENST00000390668.3_Silent_p.G368G|FOXP2_ENST00000393498.2_Silent_p.G323G			O15409	FOXP2_HUMAN	forkhead box P2	344					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						CTCTCTATGGCCATGGAGTTT	0.458000													30	37					0	0	1	0	0
KAT5	10524	broad.mit.edu	37	11	65484141	65484141	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:65484141T>C	ENST00000341318.4	+	9	1267	c.1033T>C	c.(1033-1035)Tat>Cat	p.Y345H	KAT5_ENST00000530446.1_Missense_Mutation_p.Y293H|KAT5_ENST00000534650.1_Missense_Mutation_p.Y101H|KAT5_ENST00000352980.4_Missense_Mutation_p.Y260H|KAT5_ENST00000377046.3_Missense_Mutation_p.Y312H	NM_182710.2	NP_874369.1	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5	312					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)	21						CTTGCAGAGTTATTCCCAGAA	0.498000													53	75					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53238382	53238382	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:53238382C>T	ENST00000359499.4	-	5	563	c.552G>A	c.(550-552)cgG>cgA	p.R184R	KRT78_ENST00000304620.4_Silent_p.R294R			Q8N1N4	K2C78_HUMAN	keratin 78	294	Coil 1B.|Rod.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						CCTTGCTGCTCCGGGCGATCT	0.612000													55	39					0	0	1	0	0
CREB3L2	64764	broad.mit.edu	37	7	137567225	137567225	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:137567225G>A	ENST00000330387.6	-	11	1771	c.1420C>T	c.(1420-1422)Ccc>Tcc	p.P474S		NM_194071.3	NP_919047.2	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like 2	474					chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	breast(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						ATGAAATGGGGAAGATCCACA	0.587000			T	FUS	fibromyxoid sarcoma								41	56					0	0	1	0	0
FCAMR	83953	broad.mit.edu	37	1	207135887	207135887	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:207135887G>A	ENST00000324852.4	-	5	797	c.323C>T	c.(322-324)tCa>tTa	p.S108L	FCAMR_ENST00000450945.2_Missense_Mutation_p.S108L|FCAMR_ENST00000400962.3_Missense_Mutation_p.S108L	NM_001170631.1	NP_001164102.1	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity	63	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity	p.S84*(1)|p.S108*(1)		endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(1)	11						GCCCTTCAATGAATTTGGAGC	0.527000													9	15					0	0	1	0	0
ZNF165	7718	broad.mit.edu	37	6	28054000	28054000	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:28054000T>C	ENST00000377325.1	+	3	1018	c.462T>C	c.(460-462)ccT>ccC	p.P154P		NM_003447.3	NP_003438.1	P49910	ZN165_HUMAN	zinc finger protein 165	154					viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AAGTGTCACCTCCTGGACCAG	0.438000													39	76					0	0	1	0	0
PRRG3	79057	broad.mit.edu	37	X	150869415	150869415	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:150869415G>A	ENST00000370353.3	+	4	996	c.606G>A	c.(604-606)gaG>gaA	p.E202E	PRRG3_ENST00000538575.1_Silent_p.E202E			Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)	202						extracellular region|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(3)|prostate(2)|skin(3)	24	Acute lymphoblastic leukemia(192;6.56e-05)					CGCCCCAAGAGAGCAGCAGTG	0.617000													52	5					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72170466	72170466	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:72170466C>T	ENST00000537465.1	-	9	1242	c.1084G>A	c.(1084-1086)Gag>Aag	p.E362K	PMFBP1_ENST00000355636.6_Missense_Mutation_p.E217K|PMFBP1_ENST00000237353.10_Missense_Mutation_p.E362K			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	362										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				GATGTCTCCTCCCGCAGTCCG	0.582000													40	59					0	0	1	0	0
BCAM	4059	broad.mit.edu	37	19	45322372	45322372	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:45322372G>A	ENST00000391955.1	+	11	1440	c.1396G>A	c.(1396-1398)Gga>Aga	p.G466R	BCAM_ENST00000270233.6_Missense_Mutation_p.G466R			P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	466	Ig-like C2-type 3.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				CTGGAGGGAAGGAGACGAAGT	0.602000													121	133					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51287473	51287473	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:51287473A>G	ENST00000395542.2	-	2	394	c.210T>C	c.(208-210)ccT>ccC	p.P70P	COBL_ENST00000395540.2_Silent_p.P70P|COBL_ENST00000441453.1_Silent_p.P70P|COBL_ENST00000265136.7_Silent_p.P70P			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	70										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CCAGCCCACTAGGCAGGACCA	0.622000													29	104					0	0	1	0	0
CRP	1401	broad.mit.edu	37	1	159684231	159684231	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:159684231A>G	ENST00000255030.5	-	1	148	c.45T>C	c.(43-45)caT>caC	p.H15H	CRP_ENST00000368110.1_Silent_p.H15H|CRP_ENST00000343919.2_Silent_p.H15H|CRP_ENST00000368111.1_Silent_p.H15H|CRP_ENST00000368112.1_Silent_p.H15H|CRP_ENST00000437342.1_Intron	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	15					acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	GGCCAAAAGCATGAGAGAGGC	0.498000													16	13					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179438979	179438979	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179438979G>A	ENST00000589042.1	-	326	72104	c.71880C>T	c.(71878-71880)atC>atT	p.I23960I	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.I22319I|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Silent_p.I15020I|TTN_ENST00000342992.6_Silent_p.I21392I|TTN_ENST00000460472.2_Silent_p.I14895I|TTN_ENST00000342175.6_Silent_p.I15087I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22319							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTTTCAACGATATAACTGG	0.413000													59	35					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23898176	23898176	+	Silent	SNP	G	G	A	rs45508293	byFrequency	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:23898176G>A	ENST00000355349.3	-	14	1557	c.1395C>T	c.(1393-1395)ttC>ttT	p.F465F		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	465	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.F465F(2)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CGAAGATCTCGAAGCCAGCGA	0.542000													31	28					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123810973	123810973	+	Missense_Mutation	SNP	C	C	T	rs138187932		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:123810973C>T	ENST00000307033.2	+	1	724	c.650C>T	c.(649-651)tCg>tTg	p.S217L		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	217					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CTTCTGGGATCGTACACAGCA	0.517000													111	155					0	0	1	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155922468	155922468	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:155922468G>A	ENST00000368316.1	-	19	2321	c.1851C>T	c.(1849-1851)tcC>tcT	p.S617S	ARHGEF2_ENST00000313667.4_Silent_p.S644S|ARHGEF2_ENST00000313695.7_Silent_p.S617S|ARHGEF2_ENST00000368315.3_Silent_p.S646S|ARHGEF2_ENST00000361247.4_Silent_p.S645S			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	645					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGGACTCAAGGGACTCAGAGC	0.637000													39	65					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169938332	169938332	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:169938332C>T	ENST00000327239.4	+	5	1745	c.241C>T	c.(241-243)Ctt>Ttt	p.L81F	DHRS9_ENST00000602501.1_Missense_Mutation_p.L81F|DHRS9_ENST00000421653.1_5'UTR|DHRS9_ENST00000428522.1_Missense_Mutation_p.L81F|DHRS9_ENST00000357546.2_Missense_Mutation_p.L81F|DHRS9_ENST00000432060.2_Missense_Mutation_p.L141F|DHRS9_ENST00000412271.1_Missense_Mutation_p.L81F|DHRS9_ENST00000436483.2_Missense_Mutation_p.L81F	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	81					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						TCGTACTGTGCTTCTGGATGT	0.473000													64	40					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854213	12854213	+	Missense_Mutation	SNP	C	C	T	rs147163117		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:12854213C>T	ENST00000332296.7	+	3	540	c.437C>T	c.(436-438)cCc>cTc	p.P146L		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	146										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCACCAGCCCTTAAAGGTG	0.542000													123	219					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739651	38739651	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:38739651C>T	ENST00000449082.2	-	27	5059	c.5060G>A	c.(5059-5061)gGc>gAc	p.G1687D		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1687					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCCTCTGGTGCCATTGCTGTT	0.572000													36	62					0	0	1	0	0
KLHL23	151230	broad.mit.edu	37	2	170592400	170592400	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:170592400G>A	ENST00000392647.2	+	2	1120	c.876G>A	c.(874-876)tgG>tgA	p.W292*	KLHL23_ENST00000602521.1_Intron|KLHL23_ENST00000272797.4_Nonsense_Mutation_p.W292*	NM_144711.5	NP_653312.2	Q8NBE8	KLH23_HUMAN	kelch-like family member 23	292										breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(4)|skin(1)|urinary_tract(1)	16						TTCACATATGGGATCCTTTGA	0.413000													174	111					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22035147	22035147	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:22035147C>T	ENST00000354870.5	+	6	1064	c.798C>T	c.(796-798)tcC>tcT	p.S266S	BMP1_ENST00000397816.3_Intron|BMP1_ENST00000306385.5_Intron|BMP1_ENST00000306349.8_Intron|BMP1_ENST00000397814.3_Intron			P13497	BMP1_HUMAN	bone morphogenetic protein 1	0	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		TCCCATGTTCCCTTGAGTCCT	0.612000													88	10					0	0	1	0	0
WDR7	23335	broad.mit.edu	37	18	54446734	54446734	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:54446734C>T	ENST00000254442.3	+	18	3231	c.3020C>T	c.(3019-3021)cCc>cTc	p.P1007L	WDR7_ENST00000589935.1_Intron|WDR7_ENST00000357574.3_Missense_Mutation_p.P974L	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	1007										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		TTTAGGCCTCCCCTTCTGGAG	0.403000													42	9					0	0	1	0	0
LDHC	3948	broad.mit.edu	37	11	18451355	18451355	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:18451355C>T	ENST00000541669.1	+	4	427	c.316C>T	c.(316-318)Cgc>Tgc	p.R106C	LDHC_ENST00000280704.4_Missense_Mutation_p.R106C|LDHC_ENST00000544105.1_Missense_Mutation_p.R106C|LDHC_ENST00000537486.1_Missense_Mutation_p.R106C|LDHC_ENST00000536880.1_Missense_Mutation_p.R92C|LDHC_ENST00000546146.1_Intron|LDHC_ENST00000535809.1_Missense_Mutation_p.R106C			P07864	LDHC_HUMAN	lactate dehydrogenase C	106					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24					NADH(DB00157)	GGGAGAAACTCGCCTTGCCCT	0.393000													44	59					0	0	1	0	0
PARP16	54956	broad.mit.edu	37	15	65558937	65558937	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:65558937G>A	ENST00000261888.6	-	3	927	c.482C>T	c.(481-483)tCc>tTc	p.S161F	PARP16_ENST00000558873.1_5'UTR|PARP16_ENST00000444347.2_Intron	NM_017851.4	NP_060321.3	Q8N5Y8	PAR16_HUMAN	poly (ADP-ribose) polymerase family, member 16	161	PARP catalytic.					integral to membrane	NAD+ ADP-ribosyltransferase activity			kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	9						GTGGATAATGGAATGGAAGTT	0.507000													27	45					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34204825	34204825	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:34204825G>A	ENST00000373381.4	-	15	2460	c.2284C>T	c.(2284-2286)Ctt>Ttt	p.L762F		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	722	CUB 5.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGAGTCCCAAGGAAGCCTTCA	0.607000													39	38					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316594	30316594	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:30316594G>A	ENST00000375377.1	-	3	2584	c.2483C>T	c.(2482-2484)cCc>cTc	p.P828L		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	828										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						CAAATCCCAGGGACGACGGCT	0.557000													6	126					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86124981	86124981	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:86124981C>T	ENST00000394518.2	+	7	3777	c.3682C>T	c.(3682-3684)Ccc>Tcc	p.P1228S	AKAP13_ENST00000361243.2_Missense_Mutation_p.P1228S	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1228					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						AAGGAGCACTCCCTCTCTACC	0.607000													22	26					0	0	1	0	0
IGSF8	93185	broad.mit.edu	37	1	160061618	160061618	+	Missense_Mutation	SNP	G	G	A	rs150306822		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:160061618G>A	ENST00000368086.1	-	6	2053	c.1837C>T	c.(1837-1839)Cgg>Tgg	p.R613W	IGSF8_ENST00000314485.7_Missense_Mutation_p.R613W			Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	613					cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(19)|pancreas(1)|prostate(1)|skin(1)	33	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			AGGGATCACCGTTTTCGAAGC	0.562000													34	48					0	0	1	0	0
IGFL1	374918	broad.mit.edu	37	19	46733596	46733596	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:46733596G>A	ENST00000437936.1	+	3	168	c.145G>A	c.(145-147)Gac>Aac	p.D49N	AC006262.10_ENST00000597337.1_RNA	NM_198541.1	NP_940943.1	Q6UW32	IGFL1_HUMAN	IGF-like family member 1	49						extracellular space	protein binding			lung(5)	5		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.00242)|all cancers(93;0.0132)|GBM - Glioblastoma multiforme(486;0.0294)|Epithelial(262;0.201)		CAAGTTCTACGACCCCCTGCA	0.572000													77	87					0	0	1	0	0
CASP10	843	broad.mit.edu	37	2	202050808	202050808	+	Missense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:202050808A>T	ENST00000286186.6	+	2	743	c.308A>T	c.(307-309)gAg>gTg	p.E103V	CASP10_ENST00000346817.5_Missense_Mutation_p.E103V|CASP10_ENST00000492363.1_3'UTR|CASP10_ENST00000272879.5_Missense_Mutation_p.E103V|CASP10_ENST00000313728.7_Missense_Mutation_p.E103V|CASP10_ENST00000374650.3_Missense_Mutation_p.E103V|CASP10_ENST00000360132.3_Missense_Mutation_p.E103V|CASP10_ENST00000448480.1_Missense_Mutation_p.E103V	NM_032977.3	NP_116759.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	103					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						GAGGAAGTGGAGCGACTGCTG	0.527000													22	64					0	0	1	0	0
TBX18	9096	broad.mit.edu	37	6	85446770	85446770	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:85446770G>A	ENST00000369663.5	-	8	1794	c.1457C>T	c.(1456-1458)tCc>tTc	p.S486F	TBX18_ENST00000606784.1_Intron	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	486					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		AATCTGCATGGATAAGCTGGT	0.557000													69	76					0	0	1	0	0
TBR1	10716	broad.mit.edu	37	2	162273027	162273027	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:162273027G>A	ENST00000389554.3	+	1	423	c.106G>A	c.(106-108)Gat>Aat	p.D36N		NM_006593.2	NP_006584.1	Q16650	TBR1_HUMAN	T-box, brain, 1	36						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(3)	30						TGTCTTGCACGATCATCCCAT	0.468000													32	36					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36257658	36257658	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:36257658C>T	ENST00000296604.3	-	9	1155	c.669_splice	c.e9-1	p.G224_splice	RANBP3L_ENST00000502994.1_Splice_Site_p.G249_splice|RANBP3L_ENST00000515759.1_Splice_Site_p.G224_splice	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	224					intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			TTTTGAGTACCCTGAGAGCGG	0.333000													11	36					0	0	1	0	0
NT5DC2	64943	broad.mit.edu	37	3	52559077	52559077	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:52559077G>A	ENST00000307076.4	-	12	1538	c.1138C>T	c.(1138-1140)Ccc>Tcc	p.P380S	NT5DC2_ENST00000422318.2_Missense_Mutation_p.P417S|NT5DC2_ENST00000459839.1_Missense_Mutation_p.P392S|NT5DC2_ENST00000307092.4_Missense_Mutation_p.P321S	NM_022908.2	NP_075059.1	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2	380							hydrolase activity|metal ion binding			endometrium(1)|lung(3)|prostate(1)|stomach(1)	6				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		TCCAGCTCGGGGATGATGGCG	0.687000													12	9					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186673384	186673384	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:186673384C>T	ENST00000343098.5	+	17	19618	c.19618C>T	c.(19618-19620)Cct>Tct	p.P6540S	FSIP2_ENST00000424728.1_Missense_Mutation_p.P6451S	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						TACAGCCTTTCCTAAAAAAGT	0.313000													31	60					0	0	1	0	0
AFF4	27125	broad.mit.edu	37	5	132270562	132270562	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:132270562G>A	ENST00000265343.5	-	3	574	c.195C>T	c.(193-195)ttC>ttT	p.F65F	AFF4_ENST00000491831.1_5'UTR|AFF4_ENST00000378595.3_Silent_p.F65F	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	65					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGTCTCCTATGAAATCCTTCA	0.333000													70	46					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82583815	82583815	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:82583815C>T	ENST00000423517.2	-	5	6791	c.6454G>A	c.(6454-6456)Gaa>Aaa	p.E2152K	PCLO_ENST00000333891.8_Missense_Mutation_p.E2152K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2083					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCTTGAATTTCTCTTGTATAA	0.413000													34	49					0	0	1	0	0
OOEP	441161	broad.mit.edu	37	6	74078978	74078978	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:74078978C>T	ENST00000370363.1	-	3	648	c.156G>A	c.(154-156)aaG>aaA	p.K52K	OOEP_ENST00000370359.5_Silent_p.K107K			A6NGQ2	OOEP_HUMAN	oocyte expressed protein	107	KH; atypical.					cytoplasm				large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	8						GGAGCATGCTCTTCACCCGAT	0.567000													18	31					0	0	1	0	0
ARNT2	9915	broad.mit.edu	37	15	80845064	80845064	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:80845064C>T	ENST00000533983.1	+	11	1344	c.1005C>T	c.(1003-1005)atC>atT	p.I335I	ARNT2_ENST00000527771.1_Silent_p.I335I|ARNT2_ENST00000303329.4_Silent_p.I346I			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	346	PAS 2.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			CCGATGGAATCATCACATTTG	0.463000													48	78					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79032713	79032713	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:79032713C>T	ENST00000446378.2	+	2	8156	c.8125C>T	c.(8125-8127)Cct>Tct	p.P2709S		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2709						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CCAACCACGTCCTTTAGAAGA	0.408000													32	19					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211093123	211093123	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:211093123C>T	ENST00000367007.4	-	7	1409	c.1240G>A	c.(1240-1242)Gaa>Aaa	p.E414K	KCNH1_ENST00000271751.4_Missense_Mutation_p.E441K	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	441					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GGACCACCTTCCCACTTCCCT	0.527000													56	70					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78212361	78212361	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:78212361C>T	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCGACATTTTCCACATCCTCT	0.498000													53	81					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99513806	99513806	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:99513806G>A	ENST00000261037.3	+	5	1441	c.1061G>A	c.(1060-1062)gGc>gAc	p.G354D	COL8A1_ENST00000273342.4_Missense_Mutation_p.G354D	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	354	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGGAAACCAGGCTTCCCAGGA	0.622000													19	20					0	0	1	0	0
ANKEF1	63926	broad.mit.edu	37	20	10023882	10023882	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:10023882C>T	ENST00000378380.3	+	3	788	c.459C>T	c.(457-459)ttC>ttT	p.F153F	ANKEF1_ENST00000488991.1_3'UTR|ANKEF1_ENST00000378392.1_Silent_p.F153F|SNAP25-AS1_ENST00000603542.1_RNA|SNAP25-AS1_ENST00000421143.2_RNA	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		AGCCAATATTCCTTAGAGCTT	0.418000													48	80					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3256960	3256960	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:3256960C>T	ENST00000602557.1	-	17	2916	c.2361G>A	c.(2359-2361)tgG>tgA	p.W787*	CSMD1_ENST00000539096.1_Nonsense_Mutation_p.W786*|CSMD1_ENST00000537824.1_Nonsense_Mutation_p.W786*|CSMD1_ENST00000542608.1_Nonsense_Mutation_p.W786*|CSMD1_ENST00000602723.1_Nonsense_Mutation_p.W787*|CSMD1_ENST00000400186.3_Nonsense_Mutation_p.W787*|CSMD1_ENST00000520002.1_Nonsense_Mutation_p.W787*			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	787	CUB 5.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTTCAATTATCCATTCACAAT	0.403000													41	6					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28588091	28588091	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:28588091G>A	ENST00000434452.1	-	11	1708	c.1554C>T	c.(1552-1554)atC>atT	p.I518I	DSC3_ENST00000360428.4_Silent_p.I518I	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	518	Cadherin 4.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CATCAATGGTGATCCAACCTT	0.318000													18	19					0	0	1	0	0
OR7A17	26333	broad.mit.edu	37	19	14992139	14992139	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:14992139G>A	ENST00000327462.2	-	1	125	c.29C>T	c.(28-30)tCa>tTa	p.S10L		NM_030901.1	NP_112163.1	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A, member 17	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	12	Ovarian(108;0.203)					AACAAATTCTGAAATCCCTGT	0.368000													13	24					0	0	1	0	0
MYCN	4613	broad.mit.edu	37	2	16086021	16086021	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:16086021C>T	ENST00000281043.3	+	3	1494	c.1197C>T	c.(1195-1197)tcC>tcT	p.S399S		NM_005378.4	NP_005369.2	P04198	MYCN_HUMAN	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog	399	Helix-loop-helix motif.				regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	31	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			ACCTTCGGTCCAGCTTTCTCA	0.572000			A		neuroblastoma								77	90					0	0	1	0	0
CLCNKA	1187	broad.mit.edu	37	1	16353034	16353034	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:16353034C>T	ENST00000375692.1	+	7	630	c.502C>T	c.(502-504)Cct>Tct	p.P168S	CLCNKA_ENST00000464764.1_3'UTR|CLCNKA_ENST00000439316.2_Missense_Mutation_p.P125S|CLCNKA_ENST00000420078.1_Missense_Mutation_p.P168S|CLCNKA_ENST00000331433.4_Missense_Mutation_p.P168S			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	168					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	TCTGCAGGGCCCTTTCGTGCA	0.657000													48	37					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112669439	112669439	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:112669439G>A	ENST00000550722.1	-	39	6035	c.5640C>T	c.(5638-5640)atC>atT	p.I1880I	HECTD4_ENST00000430131.2_Silent_p.I1604I|HECTD4_ENST00000377560.5_Silent_p.I1854I	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		CAATGCTGACGATGAGGCCTG	0.552000													18	46					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4835830	4835830	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:4835830A>G	ENST00000252318.2	+	2	681	c.344A>G	c.(343-345)cAa>cGa	p.Q115R	RP11-234B24.6_ENST00000544741.2_3'UTR	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	115						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						CACAAAACCCAAATGAAACTC	0.498000													15	9					0	0	1	0	0
ASPH	444	broad.mit.edu	37	8	62566184	62566184	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:62566184G>A	ENST00000541428.1	-	4	431	c.271C>T	c.(271-273)Ccg>Tcg	p.P91S	ASPH_ENST00000379454.4_Missense_Mutation_p.P120S|ASPH_ENST00000517847.2_Missense_Mutation_p.P106S|ASPH_ENST00000522835.1_Missense_Mutation_p.P106S|ASPH_ENST00000518068.1_Missense_Mutation_p.P120S|ASPH_ENST00000445642.3_Missense_Mutation_p.P106S|ASPH_ENST00000517903.1_Missense_Mutation_p.P106S|ASPH_ENST00000356457.5_Missense_Mutation_p.P120S	NM_001164750.1	NP_001158222.1	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase	120					muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			breast(1)|cervix(1)|endometrium(5)|large_intestine(5)|lung(16)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	TCTTCTGGCGGGACTGCTGGC	0.502000													37	39					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86375685	86375685	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:86375685C>T	ENST00000370571.2	-	26	2984	c.2616_splice	c.e26-1	p.G873_splice	COL24A1_ENST00000436319.1_Splice_Site_p.G873_splice	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	873	Collagen-like 6.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TCCACGTTCTCCCTTTTAAGA	0.383000													83	121					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79026044	79026044	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:79026044G>A	ENST00000446378.2	+	2	1487	c.1456G>A	c.(1456-1458)Gaa>Aaa	p.E486K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	486	Glu-rich.					perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGAGAAGGAGGAAAACATGCT	0.468000													70	63					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93027027	93027027	+	Missense_Mutation	SNP	G	G	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:93027027G>C	ENST00000523629.1	-	4	702	c.248C>G	c.(247-249)tCt>tGt	p.S83C	RUNX1T1_ENST00000436581.2_Missense_Mutation_p.S94C|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.S46C|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.S56C|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.S46C|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.S83C|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.S46C|RUNX1T1_ENST00000521553.1_Missense_Mutation_p.S46C|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.S56C	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	83					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GGCTGTAGGAGAATGGCTCGT	0.498000													23	43					0	0	1	0	0
EEF1G	1937	broad.mit.edu	37	11	62327779	62327779	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:62327779G>A	ENST00000378019.3	-	8	1245	c.1155C>T	c.(1153-1155)acC>acT	p.T385T	EEF1G_ENST00000329251.4_Silent_p.T335T|MIR3654_ENST00000496634.2_3'UTR			P26641	EF1G_HUMAN	eukaryotic translation elongation factor 1 gamma	335	EF-1-gamma C-terminal.				response to virus	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						AGCTCATGAAGGTCTGAGTGA	0.498000													17	18					0	0	1	0	0
ZBTB44	29068	broad.mit.edu	37	11	130109726	130109726	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:130109726G>A	ENST00000525842.1	-	3	1451	c.1084C>T	c.(1084-1086)Cct>Tct	p.P362S	ZBTB44_ENST00000530205.1_Missense_Mutation_p.P362S|ZBTB44_ENST00000357899.4_Missense_Mutation_p.P362S|ZBTB44_ENST00000397753.1_Missense_Mutation_p.P362S	NM_014155.4	NP_054874.3	Q8NCP5	ZBT44_HUMAN	zinc finger and BTB domain containing 44	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	15	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0192)|Lung(977;0.235)		TCATCCGGAGGAGCATTAGTG	0.433000													11	16					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175087713	175087713	+	Missense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:175087713A>T	ENST00000239462.4	+	11	2516	c.2403A>T	c.(2401-2403)caA>caT	p.Q801H		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	801	Fibronectin type-III 7.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ACAGCCCCCAAAACCTGGTCA	0.512000													39	75					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108751586	108751586	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:108751586G>A	ENST00000232603.5	-	16	1628	c.1546C>T	c.(1546-1548)Ccc>Tcc	p.P516S	MORC1_ENST00000483760.1_Missense_Mutation_p.P516S	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	516					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						AAGCGGTTGGGATTATTAGCA	0.289000													29	37					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43683099	43683099	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:43683099G>A	ENST00000599812.1	-	3	736	c.641C>T	c.(640-642)cCc>cTc	p.P214L	PSG5_ENST00000404580.1_Intron|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000342951.6_Intron|PSG5_ENST00000366175.3_Intron|PSG5_ENST00000407356.1_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	119	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				ACATTCATAGGGTCCTGCAAT	0.502000													130	246					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140752181	140752181	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:140752181C>T	ENST00000576222.1	+	1	2351	c.2220C>T	c.(2218-2220)ctC>ctT	p.L740L	PCDHGA5_ENST00000518069.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGAGTTCTCCCCACCTACA	0.502000													23	41					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72937729	72937729	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:72937729C>T	ENST00000328801.4	+	2	315	c.315C>T	c.(313-315)ttC>ttT	p.F105F		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	105						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					GTGGCGCCTTCATCTGCAGCA	0.602000													51	62					0	0	1	0	0
PLOD2	5352	broad.mit.edu	37	3	145796919	145796919	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:145796919C>T	ENST00000282903.5	-	13	1661	c.1484G>A	c.(1483-1485)cGa>cAa	p.R495Q	RP11-274H2.2_ENST00000480247.1_RNA|PLOD2_ENST00000494950.1_Missense_Mutation_p.R440Q|PLOD2_ENST00000461497.1_Missense_Mutation_p.R155Q|PLOD2_ENST00000360060.3_Missense_Mutation_p.R495Q	NM_182943.2	NP_891988.1	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	495					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding	p.R495Q(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29					Vitamin C(DB00126)	TCTAGCATTTCGGCAAAGAGC	0.393000													70	85					0	0	1	0	0
NCAPD2	9918	broad.mit.edu	37	12	6631172	6631172	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:6631172C>T	ENST00000315579.5	+	15	2722	c.1923C>T	c.(1921-1923)atC>atT	p.I641I	NCAPD2_ENST00000545962.1_Silent_p.I596I	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	641					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						TTGGCATCATCAGCAAGATGA	0.423000													28	66					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144946821	144946821	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:144946821G>A	ENST00000525985.1	-	2	672	c.601C>T	c.(601-603)Ctc>Ttc	p.L201F				P58107	EPIPL_HUMAN	epiplakin 1	201						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TTGGGGTCGAGGAAGCGCAGG	0.662000													17	24					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155449108	155449108	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:155449108G>A	ENST00000368346.3	-	3	4192	c.3553C>T	c.(3553-3555)Cct>Tct	p.P1185S	ASH1L_ENST00000392403.3_Missense_Mutation_p.P1185S			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1185					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			ATTGGGGAAGGAGTAGCTTCT	0.453000													46	48					0	0	1	0	0
CDK10	8558	broad.mit.edu	37	16	89758292	89758292	+	Silent	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:89758292T>A	ENST00000331006.8	+	4	2014	c.273T>A	c.(271-273)gcT>gcA	p.A91A	CDK10_ENST00000505473.1_Silent_p.A67A|CDK10_ENST00000353379.7_Silent_p.A138A			Q15131	CDK10_HUMAN	cyclin-dependent kinase 10	138	Protein kinase.				negative regulation of cell proliferation|traversing start control point of mitotic cell cycle		ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(1)	1		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0276)		TCTCGGAGGCTCAGGTGCGTG	0.562000													26	30					0	0	1	0	0
CDRT15	146822	broad.mit.edu	37	17	14140027	14140027	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:14140027T>C	ENST00000420162.2	-	1	139	c.124A>G	c.(124-126)Ata>Gta	p.I42V	CDRT15_ENST00000431716.2_Missense_Mutation_p.N17S	NM_001007530.1	NP_001007531.1	Q96T59	CDRTF_HUMAN	CMT1A duplicated region transcript 15	42										endometrium(2)|large_intestine(1)|lung(2)|prostate(1)	6				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		ATGCGCCTTATTACAACGGGC	0.602000													18	28					0	0	1	0	0
RUSC2	9853	broad.mit.edu	37	9	35547173	35547173	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:35547173G>A	ENST00000455600.1	+	2	1224	c.655G>A	c.(655-657)Gat>Aat	p.D219N	RUSC2_ENST00000468041.1_3'UTR	NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	219						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			TGGAGCCAGCGATACCTCTGG	0.617000													49	8					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54537603	54537603	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:54537603C>T	ENST00000474759.1	+	5	514	c.466C>T	c.(466-468)Cca>Tca	p.P156S	CACNA2D3_ENST00000415676.2_Missense_Mutation_p.P156S|CACNA2D3_ENST00000490478.1_Missense_Mutation_p.P62S|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.P156S	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	156						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CATCTTAGCCCCAAATGACCA	0.408000													37	62					0	0	1	0	0
MSL3P1	151507	broad.mit.edu	37	2	234775044	234775044	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:234775044G>A	ENST00000438684.1	-	0	1070					NR_024322.1																						TGTCAGGTACGAGCTTCCAGG	0.488000													63	108					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158323824	158323824	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:158323824G>A	ENST00000444681.2	+	1	339	c.46G>A	c.(46-48)Gaa>Aaa	p.E16K	CD1E_ENST00000368160.3_Missense_Mutation_p.E16K|CD1E_ENST00000434258.1_Intron|CD1E_ENST00000368167.3_Missense_Mutation_p.E16K|CD1E_ENST00000368157.1_Missense_Mutation_p.E16K|CD1E_ENST00000368166.3_Missense_Mutation_p.E16K|CD1E_ENST00000368164.3_Missense_Mutation_p.E16K|CD1E_ENST00000368165.3_Missense_Mutation_p.E16K|CD1E_ENST00000368156.1_Missense_Mutation_p.E16K|CD1E_ENST00000368155.3_Missense_Mutation_p.E16K|CD1E_ENST00000368163.3_Missense_Mutation_p.E16K|CD1E_ENST00000368161.3_Missense_Mutation_p.E16K|CD1E_ENST00000452291.2_Missense_Mutation_p.E16K|CD1E_ENST00000368154.1_Missense_Mutation_p.E16K	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	16					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					CTGTCCTGGGGAAAATACAGC	0.542000													23	37					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	83635777	83635777	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:83635777G>A	ENST00000404547.1	+	1	681	c.681G>A	c.(679-681)gcG>gcA	p.A227A	NRG3_ENST00000372141.2_Silent_p.A227A			P56975	NRG3_HUMAN	neuregulin 3	227	Ser/Thr-rich.				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GGCCTACTGCGGCATACGCTA	0.617000													16	19					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173730523	173730523	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:173730523G>A	ENST00000506823.1	+	6	1222	c.565G>A	c.(565-567)Gat>Aat	p.D189N	GALNTL6_ENST00000508122.1_Missense_Mutation_p.D172N	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	189	Catalytic subdomain A.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						ACACCTGAAGGATAAATTGGA	0.428000													44	61					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119965159	119965159	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:119965159G>A	ENST00000543831.1	+	4	1284	c.1035G>A	c.(1033-1035)tgG>tgA	p.W345*	HSD3B2_ENST00000369416.3_Nonsense_Mutation_p.W345*	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	345					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	TCTACAGCTGGGAGGAAGCCA	0.512000													30	47					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169529894	169529894	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:169529894G>A	ENST00000367796.3	-	4	685	c.484C>T	c.(484-486)Cat>Tat	p.H162Y	F5_ENST00000367797.3_Missense_Mutation_p.H162Y|F5_ENST00000546081.1_Missense_Mutation_p.H25Y			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	162	F5/8 type A 1.|Plastocyanin-like 1.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GGGTCATCATGGGTGGGTCCA	0.512000													79	98					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110527488	110527488	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:110527488G>A	ENST00000378402.5	+	72	11747	c.11643G>A	c.(11641-11643)tgG>tgA	p.W3881*		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3881					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTACAATATGGAATGCCCAGC	0.328000										HNSCC(38;0.096)			17	26					0	0	1	0	0
CCT5	22948	broad.mit.edu	37	5	10250465	10250465	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:10250465G>A	ENST00000280326.4	+	1	433	c.13G>A	c.(13-15)Ggg>Agg	p.G5R	CCT5_ENST00000503026.1_Intron|CCT5_ENST00000515390.1_Missense_Mutation_p.G5R	NM_012073.3	NP_036205.1	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	5					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(2)	26						GGCGTCCATGGGGACCCTCGC	0.577000													28	7					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106401576	106401576	+	Missense_Mutation	SNP	C	C	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:106401576C>G	ENST00000369701.3	+	1	718	c.491C>G	c.(490-492)tCc>tGc	p.S164C		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	164						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GCTAAGGGTTCCCGGGAGGAG	0.721000													5	0					0	0	1	0	0
ETV7	51513	broad.mit.edu	37	6	36334487	36334487	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:36334487G>A	ENST00000373738.1	-	7	1641	c.796C>T	c.(796-798)Ccg>Tcg	p.P266S	ETV7_ENST00000373737.4_Missense_Mutation_p.P244S|ETV7_ENST00000340181.4_Missense_Mutation_p.P321S|ETV7_ENST00000339796.5_Intron|ETV7_ENST00000538992.1_Missense_Mutation_p.P170S	NM_001207036.1	NP_001193965.1	Q9Y603	ETV7_HUMAN	ets variant 7	321					organ morphogenesis|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|skin(4)	10						CTCTCCAGCGGCTCCAGGTGG	0.577000													35	109					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4869575	4869575	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:4869575G>A	ENST00000322101.2	-	1	939	c.864C>T	c.(862-864)ttC>ttT	p.F288F	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	288					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAGGAAGAAGGAAATGGACAT	0.448000													49	82					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120655783	120655783	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:120655783C>T	ENST00000310396.5	+	3	781	c.314C>T	c.(313-315)cCt>cTt	p.P105L	CPED1_ENST00000450913.2_Missense_Mutation_p.P105L|CPED1_ENST00000495036.1_3'UTR|CPED1_ENST00000340646.5_Missense_Mutation_p.P105L	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		TACAGGCCTCCTTTCTACAGC	0.448000													24	37					0	0	1	0	0
PROX2	283571	broad.mit.edu	37	14	75329906	75329906	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:75329906T>A	ENST00000556084.2	-	1	631	c.632A>T	c.(631-633)aAg>aTg	p.K211M	PROX2_ENST00000445876.1_Missense_Mutation_p.K211M|PROX2_ENST00000556489.2_Missense_Mutation_p.K211M	NM_001080408.2	NP_001073877.2	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	211					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(3)	6			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		GAAACTGGGCTTCTCAGACTC	0.562000													34	2					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140476315	140476315	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:140476315G>A	ENST00000194155.4	+	1	2089	c.1941G>A	c.(1939-1941)aaG>aaA	p.K647K		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		647	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTGGTCAAGGACAATGGCG	0.716000													40	48					0	0	1	0	0
OR7D2	162998	broad.mit.edu	37	19	9296468	9296468	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:9296468G>A	ENST00000344248.2	+	1	190	c.11G>A	c.(10-12)gGa>gAa	p.G4E		NM_175883.2	NP_787079.1	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D, member 2	4					regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	20						ATGGAAGCAGGAAACCAAACA	0.483000													18	22					0	0	1	0	0
RBMXL3	139804	broad.mit.edu	37	X	114424132	114424132	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:114424132G>A	ENST00000424776.3	+	1	170	c.128G>A	c.(127-129)cGa>cAa	p.R43Q	LRCH2_ENST00000317135.8_Intron|LRCH2_ENST00000538422.1_Intron	NM_001145346.1	NP_001138818.1	Q8N7X1	RMXL3_HUMAN	RNA binding motif protein, X-linked-like 3	43	RRM.						nucleotide binding|RNA binding			endometrium(13)|kidney(2)|skin(1)	16						ATGAAAGACCGAAAAACCAAC	0.532000													6	0					0	0	1	0	0
KATNAL1	84056	broad.mit.edu	37	13	30782818	30782818	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:30782818G>A	ENST00000380615.3	-	11	1499	c.1332C>T	c.(1330-1332)atC>atT	p.I444I	KATNAL1_ENST00000380617.3_Silent_p.I444I	NM_032116.4	NP_115492.1	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	444						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)|urinary_tract(3)	19		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		AAAGTGCACGGATTTCTTCTG	0.408000													37	82					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84710896	84710896	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:84710896C>T	ENST00000284136.6	-	3	356		c.e3-1		SEMA3D_ENST00000444867.1_Splice_Site	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D						cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						GCCAATAAATCTGCAAAACAT	0.358000													24	31					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38899722	38899722	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:38899722G>A	ENST00000359357.3	+	74	11013	c.10759G>A	c.(10759-10761)Gga>Aga	p.G3587R	RP1-207H1.3_ENST00000453417.1_RNA|DNAH8_ENST00000449981.2_Missense_Mutation_p.G3804R|RP1-207H1.3_ENST00000416948.1_RNA|DNAH8_ENST00000441566.1_Missense_Mutation_p.G3551R					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TACAATGAAAGGACTTGAGAA	0.338000													43	75					0	0	1	0	0
LOC442028	442028	broad.mit.edu	37	2	95552768	95552768	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:95552768C>T	ENST00000568768.1	-	0	476																											CTCAATTCCTCCTTTGTCATA	0.388000													20	20					0	0	1	0	0
CDK1	983	broad.mit.edu	37	10	62553692	62553692	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:62553692C>T	ENST00000448257.2	+	8	1054	c.853C>T	c.(853-855)Cca>Tca	p.P285S	CDK1_ENST00000316629.4_Missense_Mutation_p.P228S|CDK1_ENST00000373809.2_Missense_Mutation_p.P228S|CDK1_ENST00000395284.3_Missense_Mutation_p.P285S			P06493	CDK1_HUMAN	cyclin-dependent kinase 1	285	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|axon guidance|cell division|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|mitosis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein localization to kinetochore|Ras protein signal transduction|regulation of transcription involved in G1/S phase of mitotic cell cycle|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|midbody|nucleoplasm|spindle microtubule	ATP binding|cyclin-dependent protein kinase activity|RNA polymerase II carboxy-terminal domain kinase activity			ovary(1)	1						ACTGAATCATCCATATTTTAA	0.289000													26	10					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138442251	138442251	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:138442251C>T	ENST00000344876.4	-	4	3726	c.3340G>A	c.(3340-3342)Gaa>Aaa	p.E1114K	PCDH18_ENST00000511115.1_Missense_Mutation_p.E294K|PCDH18_ENST00000412923.2_Missense_Mutation_p.E1113K|PCDH18_ENST00000510305.1_Missense_Mutation_p.E325K|PCDH18_ENST00000507846.1_Missense_Mutation_p.E893K	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	1114	Interaction with DAB1 (By similarity).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TCCATGAGTTCGTGTTTCCCA	0.448000													26	31					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14857767	14857767	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:14857767G>A	ENST00000315576.3	-	17	2483	c.2032C>T	c.(2032-2034)Ctc>Ttc	p.L678F	EMR2_ENST00000346057.1_Missense_Mutation_p.L629F|EMR2_ENST00000392967.2_Missense_Mutation_p.L667F|EMR2_ENST00000594294.1_Missense_Mutation_p.L629F|EMR2_ENST00000353005.1_Missense_Mutation_p.L536F|EMR2_ENST00000392964.3_3'UTR|EMR2_ENST00000596991.2_Missense_Mutation_p.L667F|EMR2_ENST00000392965.3_Missense_Mutation_p.L620F|EMR2_ENST00000595839.1_Missense_Mutation_p.L536F|EMR2_ENST00000594076.1_Missense_Mutation_p.L585F|EMR2_ENST00000353876.1_Missense_Mutation_p.L585F|EMR2_ENST00000601345.1_Missense_Mutation_p.L667F	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	678					cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						TCTGGTTGGAGCCAGCAGCTG	0.463000													20	17					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111114468	111114468	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:111114468C>T	ENST00000360467.5	+	23	1910	c.1604C>T	c.(1603-1605)cCt>cTt	p.P535L	COL4A2-AS2_ENST00000458403.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	535	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CAGGGAGTGCCTGGCAACATT	0.512000													25	17					0	0	1	0	0
ABCD2	225	broad.mit.edu	37	12	40010843	40010843	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:40010843C>T	ENST00000308666.3	-	2	1202	c.1067G>A	c.(1066-1068)gGa>gAa	p.G356E		NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2	356	ABC transmembrane type-1.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						CATAATTAGTCCACTGCTGCT	0.353000													56	50					0	0	1	0	0
TTC6	319089	broad.mit.edu	37	14	38296443	38296443	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:38296443C>T	ENST00000553443.1	+	29	5170	c.5170C>T	c.(5170-5172)Cat>Tat	p.H1724Y	TTC6_ENST00000382320.3_Missense_Mutation_p.H438Y|TTC6_ENST00000476979.1_Missense_Mutation_p.H358Y|TTC6_ENST00000267368.7_Missense_Mutation_p.H358Y					tetratricopeptide repeat domain 6											central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	14	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;1.59e-06)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0543)|all cancers(34;0.108)|BRCA - Breast invasive adenocarcinoma(188;0.156)|LUSC - Lung squamous cell carcinoma(13;0.176)	GBM - Glioblastoma multiforme(112;0.00551)		TGGGGTGATTCATGAGTTTAT	0.363000													33	51					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906778	13906778	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:13906778C>T	ENST00000279593.3	-	3	692	c.483G>A	c.(481-483)atG>atA	p.M161I		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	161					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CATATTCTTCCATGATGTTGA	0.418000													14	23					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	117486768	117486768	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:117486768G>A	ENST00000355044.3	+	27	3932	c.3806G>A	c.(3805-3807)cGa>cAa	p.R1269Q	ATRNL1_ENST00000423111.2_Missense_Mutation_p.R320Q|ATRNL1_ENST00000303745.7_Missense_Mutation_p.R62Q	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1269						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CAACTGCTTCGAGAACGACAG	0.433000													24	6					0	0	1	0	0
COG4	25839	broad.mit.edu	37	16	70546202	70546202	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:70546202G>A	ENST00000564653.1	-	5	557	c.551C>T	c.(550-552)tCc>tTc	p.S184F	COG4_ENST00000323786.5_Silent_p.F226F|COG4_ENST00000393612.4_Silent_p.F222F			Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	0					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|pancreas(1)|prostate(2)	33		Ovarian(137;0.0694)				CCAGCAGTGGGAAGATCTTGA	0.512000													32	48					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149263002	149263002	+	Missense_Mutation	SNP	C	C	T	rs148637474		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:149263002C>T	ENST00000255266.5	-	17	2244	c.2125G>A	c.(2125-2127)Gaa>Aaa	p.E709K		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	709					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ATAACGATTTCCTTCCGTGTC	0.483000													17	23					0	0	1	0	0
SAMSN1	64092	broad.mit.edu	37	21	15884877	15884877	+	Missense_Mutation	SNP	C	C	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:15884877C>G	ENST00000285670.2	-	5	675	c.501G>C	c.(499-501)gaG>gaC	p.E167D	SAMSN1_ENST00000400566.1_Missense_Mutation_p.E99D|SAMSN1_ENST00000400564.1_Intron	NM_001256370.1	NP_001243299.1	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization signals 1	99	SH3.				negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	24				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		GGTGGGCATTCTCTCCATCTT	0.443000													4	101					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179574483	179574483	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179574483T>C	ENST00000589042.1	-	99	28787	c.28563A>G	c.(28561-28563)caA>caG	p.Q9521Q	TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Silent_p.Q9204Q|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Silent_p.Q8277Q|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9204							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGTTATAGGTTGGGAACCAG	0.413000													100	80					0	0	1	0	0
CSNK1A1P1	161635	broad.mit.edu	37	15	37110336	37110336	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:37110336G>A	ENST00000430593.3	-	0	324					NR_027320.1																						CCTGAGAGACGAAGATGGAGG	0.572000													9	0					0	0	1	0	0
NMBR	4829	broad.mit.edu	37	6	142396799	142396799	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:142396799C>T	ENST00000258042.1	-	3	1299	c.1159G>A	c.(1159-1161)Gaa>Aaa	p.E387K	NMBR_ENST00000480652.1_Intron	NM_002511.2	NP_002502.2	P28336	NMBR_HUMAN	neuromedin B receptor	387					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		AGTGCCATTTCCTGCTTCATG	0.433000													38	49					0	0	1	0	0
KRTAP3-3	85293	broad.mit.edu	37	17	39150226	39150226	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:39150226A>G	ENST00000391586.1	-	1	159	c.124T>C	c.(124-126)Tta>Cta	p.L42L		NM_033185.2	NP_149441.1	Q9BYR6	KRA33_HUMAN	keratin associated protein 3-3	42	3 X 5 AA repeats of C-C-X(3).					keratin filament	structural molecule activity			lung(2)|prostate(2)	4		Breast(137;0.00043)				GGCTCCAGTAACCAAACTGTG	0.632000													11	94					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45567078	45567078	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:45567078C>T	ENST00000588982.1	-	3	902	c.401G>A	c.(400-402)gGg>gAg	p.G134E	ZBTB7C_ENST00000332053.2_Missense_Mutation_p.G134E|ZBTB7C_ENST00000590800.1_Missense_Mutation_p.G134E|ZBTB7C_ENST00000586438.1_Missense_Mutation_p.G134E|ZBTB7C_ENST00000535628.2_Missense_Mutation_p.G134E			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	134	Asp-rich.|Glu-rich.					intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						atcctcctcccccccgtcccc	0.577000													21	23					0	0	1	0	0
RPSAP52	204010	broad.mit.edu	37	12	66152609	66152609	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:66152609G>A	ENST00000489520.2	-	0	334					NR_026825.2																						GCCAGCAGAAGCTTCTCCCAG	0.443000													24	19					0	0	1	0	0
AGL	178	broad.mit.edu	37	1	100346234	100346234	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:100346234C>T	ENST00000294724.4	+	14	2260	c.1782C>T	c.(1780-1782)taC>taT	p.Y594Y	AGL_ENST00000361915.3_Silent_p.Y594Y|AGL_ENST00000361522.4_Silent_p.Y577Y|AGL_ENST00000370165.3_Silent_p.Y594Y|AGL_ENST00000370161.2_Silent_p.Y578Y|AGL_ENST00000361302.3_Silent_p.Y578Y|AGL_ENST00000370163.3_Silent_p.Y594Y	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	594					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		GATTAGTTTACCGATATGGAG	0.398000													64	96					0	0	1	0	0
CTSW	1521	broad.mit.edu	37	11	65650792	65650792	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:65650792G>A	ENST00000528419.1	+	9	921	c.917G>A	c.(916-918)gGg>gAg	p.G306E	CTSW_ENST00000307886.3_Missense_Mutation_p.G306E			P56202	CATW_HUMAN	cathepsin W	306					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(5)	9				READ - Rectum adenocarcinoma(159;0.168)		TCAGAGGAGGGGATATGGGCA	0.602000													70	117					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40339308	40339308	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:40339308C>T	ENST00000310169.2	+	3	431	c.292C>T	c.(292-294)Cag>Tag	p.Q98*	CHRNA9_ENST00000502377.1_3'UTR	NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	98					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	GGACCGAGATCAGTACGATGG	0.478000													21	30					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107041554	107041554	+	Nonsense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:107041554T>A	ENST00000409886.3	-	20	2956	c.2869A>T	c.(2869-2871)Aag>Tag	p.K957*	RGPD3_ENST00000304514.7_Nonsense_Mutation_p.K957*	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	957					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						CCACGGCCCTTCTTCCGGCCA	0.398000													126	460					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76501376	76501376	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:76501376G>A	ENST00000307431.8	+	11	1993	c.1608G>A	c.(1606-1608)ggG>ggA	p.G536G	CNTNAP4_ENST00000377504.4_Silent_p.G488G|CNTNAP4_ENST00000478060.1_Silent_p.G464G|CNTNAP4_ENST00000476707.1_Silent_p.G540G|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	537	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GGTCCCTTGGGAACTTCAGTG	0.438000													20	24					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138452009	138452009	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:138452009C>T	ENST00000344876.4	-	1	1620	c.1234G>A	c.(1234-1236)Gaa>Aaa	p.E412K	PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000412923.2_Missense_Mutation_p.E412K|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000507846.1_Missense_Mutation_p.E192K	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	412	Cadherin 4.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TAATTGTTTTCATATGTCTTC	0.398000													48	63					0	0	1	0	0
NPY4R	5540	broad.mit.edu	37	10	47087350	47087350	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:47087350C>T	ENST00000374312.1	+	3	986	c.567C>T	c.(565-567)tcC>tcT	p.S189S	NPY4R_ENST00000395716.1_Silent_p.S189S	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		AGAACCACTCCAAGGCTCTGG	0.577000													45	55					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30936469	30936469	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:30936469G>A	ENST00000355537.3	+	2	2147	c.2000G>A	c.(1999-2001)gGc>gAc	p.G667D		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	667					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CTGCACGTGGGCCTGGATGAG	0.697000													42	41					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101581199	101581199	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:101581199G>A	ENST00000536262.2	-	7	1486	c.928C>T	c.(928-930)Cct>Tct	p.P310S		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	310					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GCTGTCCAAGGATCACAGTCA	0.438000													32	21					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578395	7578395	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:7578395G>A	ENST00000420246.2	-	5	667	c.535C>T	c.(535-537)Cat>Tat	p.H179Y	TP53_ENST00000359597.4_Missense_Mutation_p.H179Y|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000269305.4_Missense_Mutation_p.H179Y|TP53_ENST00000445888.2_Missense_Mutation_p.H179Y|TP53_ENST00000455263.2_Missense_Mutation_p.H179Y|TP53_ENST00000413465.2_Missense_Mutation_p.H179Y	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	179	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179Y(98)|p.H179N(16)|p.H179D(13)|p.P177_C182delPHHERC(8)|p.0?(8)|p.H47Y(6)|p.H86Y(6)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H178_S183delHHERCS(3)|p.R175_E180delRCPHHE(3)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.H179fs*68(1)|p.C176fs*65(1)|p.C176fs*68(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H46_S51delHHERCS(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.H85_S90delHHERCS(1)|p.H47D(1)|p.R174fs*3(1)|p.H86D(1)|p.H178_H179>QY(1)|p.H47N(1)|p.H86N(1)|p.E171fs*61(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCTCATGGTGGGGGCAG	0.642000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			40	6					0	0	1	0	0
USP53	54532	broad.mit.edu	37	4	120193177	120193177	+	Missense_Mutation	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:120193177C>A	ENST00000450251.1	+	12	2706	c.2162C>A	c.(2161-2163)aCa>aAa	p.T721K	USP53_ENST00000274030.6_Missense_Mutation_p.T721K			Q70EK8	UBP53_HUMAN	ubiquitin specific peptidase 53	721					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	27						GTTAAAGAAACAGTATGCTTC	0.333000													33	83					1.57945e-13	1.59072e-13	1	1	0
OR4K17	390436	broad.mit.edu	37	14	20586540	20586540	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:20586540G>A	ENST00000315543.4	+	1	975	c.975G>A	c.(973-975)atG>atA	p.M325I		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		ACAAAGAAATGAAGATATCCA	0.383000													15	30					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25701294	25701294	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:25701294C>T	ENST00000376351.3	+	4	1586	c.1227C>T	c.(1225-1227)ttC>ttT	p.F409F		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	409						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GCCCATGCTTCGTCCAGGAAG	0.498000													7	136					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189852853	189852853	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:189852853G>A	ENST00000304636.3	+	6	745	c.575G>A	c.(574-576)gGt>gAt	p.G192D	COL3A1_ENST00000317840.5_Missense_Mutation_p.G192D	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	192	Triple-helical region.		G -> V (in EDS4).		axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGTCATCCTGGTTCCCCTGTA	0.398000													32	93					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71697894	71697894	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:71697894G>A	ENST00000568954.1	-	13	2271	c.1893C>T	c.(1891-1893)ctC>ctT	p.L631L	PHLPP2_ENST00000393524.2_Intron|PHLPP2_ENST00000360429.3_Silent_p.L631L|PHLPP2_ENST00000567016.1_Silent_p.L666L|PHLPP2_ENST00000356272.3_Silent_p.L631L|RP11-432I5.6_ENST00000567077.1_RNA			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	631						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						GATCCGTCAGGAGATTGTTGG	0.483000													22	43					0	0	1	0	0
LARS	51520	broad.mit.edu	37	5	145493731	145493731	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:145493731G>A	ENST00000394434.2	-	32	3635	c.3469C>T	c.(3469-3471)Cat>Tat	p.H1157Y	LARS_ENST00000510191.1_Missense_Mutation_p.H1103Y|RP11-118M9.3_ENST00000514002.1_RNA|LARS_ENST00000545646.1_Missense_Mutation_p.H1111Y|LARS_ENST00000274562.9_Missense_Mutation_p.H1130Y	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	1157					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	TCAGTCAGATGAATTTTCTTG	0.448000													36	93					0	0	1	0	0
MT-CO1	4512	broad.mit.edu	37	MT	6216	6216	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrM:6216T>C	ENST00000361624.2	+	1	313	c.313T>C	c.(313-315)Tta>Cta	p.105_105insL						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						GCTTCTGACTCTTACCTCCCT	0.522000													65	88					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129238562	129238562	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:129238562C>T	ENST00000296266.3	+	30	3968	c.3776C>T	c.(3775-3777)cCc>cTc	p.P1259L	IFT122_ENST00000440957.2_Missense_Mutation_p.P999L|IFT122_ENST00000431818.2_Missense_Mutation_p.P1058L|IFT122_ENST00000504021.1_Missense_Mutation_p.P1085L|IFT122_ENST00000349441.2_Missense_Mutation_p.P1098L|IFT122_ENST00000348417.2_Missense_Mutation_p.P1208L|IFT122_ENST00000347300.2_Missense_Mutation_p.P1149L|IFT122_ENST00000507564.1_Missense_Mutation_p.P1201L	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	1208					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						ACCATGTGCCCCTCCTGCTTC	0.617000													73	72					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179453650	179453650	+	Nonsense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179453650A>T	ENST00000589042.1	-	304	63026	c.62802T>A	c.(62800-62802)taT>taA	p.Y20934*	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.Y19293*|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Nonsense_Mutation_p.Y11994*|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.Y18366*|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.Y11869*|TTN_ENST00000342175.6_Nonsense_Mutation_p.Y12061*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19293	Ig-like 112.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTGAAAATATATTCATTTC	0.413000													38	21					0	0	1	0	0
HGD	3081	broad.mit.edu	37	3	120365120	120365120	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:120365120G>A	ENST00000283871.5	-	9	1102	c.643C>T	c.(643-645)Cca>Tca	p.P215S		NM_000187.3	NP_000178.2	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	215					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)	25				GBM - Glioblastoma multiforme(114;0.158)		TTACCAATTGGTCCAAGGTCA	0.453000													33	37					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18368599	18368599	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:18368599G>A	ENST00000392413.3	-	4	3710	c.3495C>T	c.(3493-3495)acC>acT	p.T1165T	KIAA1683_ENST00000600328.2_Silent_p.T978T|KIAA1683_ENST00000600359.2_Silent_p.T932T	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	132	IQ 6.					mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CAGACTGGATGGTCGTGGTGG	0.706000													33	46					0	0	1	0	0
IGHV3-16	28447	broad.mit.edu	37	14	106622086	106622086	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:106622086C>T	ENST00000390604.2	-	0	232																											GGGCCCAGTTCATGTCACTGT	0.592000													76	172					0	0	1	0	0
SUPT16H	11198	broad.mit.edu	37	14	21826572	21826572	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:21826572C>T	ENST00000216297.2	-	20	2654	c.2316G>A	c.(2314-2316)atG>atA	p.M772I		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	772					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		GTTTGTGCCTCATTTCTCGTT	0.378000													31	22					0	0	1	0	0
NCF1B	654816	broad.mit.edu	37	7	72640017	72640017	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:72640017C>T	ENST00000423083.1	+	0	158					NR_003186.1																						ACCAAGATCTCCCGCTGTCCC	0.617000													21	29					0	0	1	0	0
FYB	2533	broad.mit.edu	37	5	39202426	39202426	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:39202426C>T	ENST00000351578.6	-	2	827	c.637G>A	c.(637-639)Gaa>Aaa	p.E213K	FYB_ENST00000515010.1_Missense_Mutation_p.E213K|FYB_ENST00000540520.1_Missense_Mutation_p.E223K|FYB_ENST00000512982.1_Missense_Mutation_p.E213K|FYB_ENST00000505428.1_Missense_Mutation_p.E213K	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	213					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding	p.E213K(2)|p.E223K(1)		endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			ATGGGGCTTTCGTCTTCATGG	0.527000													26	67					0	0	1	0	0
RIPK3	11035	broad.mit.edu	37	14	24808479	24808479	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:24808479G>A	ENST00000216274.5	-	3	431	c.213C>T	c.(211-213)ttC>ttT	p.F71F	RIPK3_ENST00000554338.1_5'UTR	NM_006871.3	NP_006862.2	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	71	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				GBM - Glioblastoma multiforme(265;0.0181)		GGCGCAGCACGAATTCGTTAT	0.567000													24	64					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7064152	7064152	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:7064152C>T	ENST00000299481.4	+	4	1241	c.895C>T	c.(895-897)Cct>Tct	p.P299S		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	299	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AGTGATGCTCCCTGAGGCATC	0.448000													45	55					0	0	1	0	0
LMOD3	56203	broad.mit.edu	37	3	69171426	69171426	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:69171426C>T	ENST00000420581.2	-	1	291	c.112G>A	c.(112-114)Gaa>Aaa	p.E38K	LMOD3_ENST00000475434.1_Missense_Mutation_p.E38K|LMOD3_ENST00000489031.1_Missense_Mutation_p.E38K	NM_198271.3	NP_938012.2	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	38						cytoplasm|cytoskeleton	tropomyosin binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)	13		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		ACTTCCATTTCCGACTGCAGT	0.443000													7	16					0	0	1	0	0
NKD2	85409	broad.mit.edu	37	5	1033528	1033528	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:1033528G>A	ENST00000296849.5	+	5	473	c.244G>A	c.(244-246)Gga>Aga	p.G82R	NKD2_ENST00000274150.4_Missense_Mutation_p.G82R|NKD2_ENST00000537972.1_Missense_Mutation_p.G82R	NM_033120.2	NP_149111.1	Q969F2	NKD2_HUMAN	naked cuticle homolog 2 (Drosophila)	82	Targeting to the basolateral cell membrane.				exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(3)|large_intestine(1)|lung(8)|pancreas(1)	14	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			CGAGCACCCGGGACAACTCCT	0.682000													8	0					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32634732	32634732	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:32634732C>T	ENST00000242310.4	-	1	935	c.846G>A	c.(844-846)agG>agA	p.R282R	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	282					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GATGCTTCTTCCTCTTTCTCC	0.463000													58	10					0	0	1	0	0
CPA6	57094	broad.mit.edu	37	8	68658323	68658323	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:68658323G>A	ENST00000297770.4	-	1	257	c.42C>T	c.(40-42)ttC>ttT	p.F14F	CPA6_ENST00000297769.4_5'UTR|CPA6_ENST00000518549.1_Silent_p.F14F	NM_020361.4	NP_065094.3	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6	14					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(5)	26			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			AAAGAGGCAGGAAAGCAGCTG	0.532000													42	56					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71139735	71139735	+	Silent	SNP	G	G	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:71139735G>C	ENST00000283228.2	-	6	1322	c.870C>G	c.(868-870)gtC>gtG	p.V290V	PTPRR_ENST00000378778.1_Silent_p.V84V|PTPRR_ENST00000342084.4_Silent_p.V178V|PTPRR_ENST00000440835.2_Silent_p.V45V|PTPRR_ENST00000549308.1_Silent_p.V45V	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	290					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GCTCAGGTTGGACCATGCTGT	0.522000													7	42					0	0	1	0	0
BZW2	28969	broad.mit.edu	37	7	16744257	16744257	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:16744257G>A	ENST00000433922.2	+	11	1372	c.1194G>A	c.(1192-1194)atG>atA	p.M398I	AC073333.8_ENST00000418907.1_RNA|BZW2_ENST00000405202.1_Missense_Mutation_p.M322I|BZW2_ENST00000407633.1_Missense_Mutation_p.M204I|BZW2_ENST00000258761.3_Missense_Mutation_p.M398I	NM_001159767.1	NP_001153239.1	Q9Y6E2	BZW2_HUMAN	basic leucine zipper and W2 domains 2	398	W2.				cell differentiation|nervous system development|RNA metabolic process		protein binding			cervix(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	15	Lung NSC(10;0.0367)|all_lung(11;0.0837)			UCEC - Uterine corpus endometrioid carcinoma (126;0.199)		TTGACCAGATGAAGAAATTTG	0.333000													19	24					0	0	1	0	0
CATSPER2P1	440278	broad.mit.edu	37	15	44028197	44028197	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:44028197G>A	ENST00000381680.2	-	0	1587					NR_002318.2																						ggctggtctcgaactcctgac	0.478000													20	4					0	0	1	0	0
CLIP4	79745	broad.mit.edu	37	2	29368177	29368177	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:29368177G>A	ENST00000320081.5	+	8	1220	c.965G>A	c.(964-966)gGa>gAa	p.G322E	CLIP4_ENST00000401617.2_Missense_Mutation_p.G215E|CLIP4_ENST00000404424.1_Missense_Mutation_p.G322E|CLIP4_ENST00000401605.1_Missense_Mutation_p.G322E	NM_024692.4	NP_078968.3	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family, member 4	322	CAP-Gly 1.									endometrium(4)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(1)	26	Acute lymphoblastic leukemia(172;0.155)					GAACCAGAAGGAAAAAATAAT	0.348000													29	32					0	0	1	0	0
HTR7	3363	broad.mit.edu	37	10	92509303	92509303	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:92509303C>T	ENST00000371721.3	-	2	830	c.588G>A	c.(586-588)ggG>ggA	p.G196G	HTR7_ENST00000277874.6_Silent_p.G196G|HTR7_ENST00000336152.3_Silent_p.G196G|HTR7_ENST00000371719.2_Silent_p.G196G			P34969	5HT7R_HUMAN	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	196					blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	CCATGCATTTCCCATTCTGCC	0.488000													46	15					0	0	1	0	0
MS4A8	83661	broad.mit.edu	37	11	60482508	60482508	+	Silent	SNP	G	G	A	rs142632950		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:60482508G>A	ENST00000300226.2	+	6	752	c.549G>A	c.(547-549)gcG>gcA	p.A183A		NM_031457.1	NP_113645.1			membrane-spanning 4-domains, subfamily A, member 8									p.A183A(1)									CTGGAATGGCGATTTCTGGCG	0.577000													51	70					0	0	1	0	0
DUSP3	1845	broad.mit.edu	37	17	41847127	41847127	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:41847127G>A	ENST00000226004.3	-	3	471	c.408C>T	c.(406-408)atC>atT	p.I136I	DUSP3_ENST00000397937.2_Silent_p.I95I	NM_004090.3	NP_004081.1	P51452	DUS3_HUMAN	dual specificity phosphatase 3	136	Tyrosine-protein phosphatase.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of JNK cascade|negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of mitotic cell cycle|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|immunological synapse|nucleoplasm	MAP kinase phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	7		Breast(137;0.00725)		BRCA - Breast invasive adenocarcinoma(366;0.116)		TGAGGTAGGCGATAACTAGCG	0.612000													32	53					0	0	1	0	0
JUP	3728	broad.mit.edu	37	17	39914700	39914700	+	Missense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:39914700A>T	ENST00000393931.3	-	10	1842	c.1724T>A	c.(1723-1725)aTg>aAg	p.M575K	JUP_ENST00000310706.5_Missense_Mutation_p.M575K|JUP_ENST00000540235.1_Intron|JUP_ENST00000393930.1_Missense_Mutation_p.M575K	NM_002230.2	NP_002221.1	P14923	PLAK_HUMAN	junction plakoglobin	575					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		CATGCGGTTCATGGGGTCCCG	0.622000													43	48					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196963290	196963290	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:196963290T>C	ENST00000367414.5	+	4	639	c.583T>C	c.(583-585)Ttg>Ctg	p.L195L	CFHR5_ENST00000256785.4_Silent_p.L171L	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	171	Sushi 3.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						TGGAGACGTGTTGAAATTCTC	0.353000													70	77					0	0	1	0	0
ZNF92	168374	broad.mit.edu	37	7	64864515	64864515	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:64864515T>A	ENST00000328747.7	+	4	1687	c.1488T>A	c.(1486-1488)ttT>ttA	p.F496L	ZNF92_ENST00000450302.2_Missense_Mutation_p.F427L|ZNF92_ENST00000357512.2_Missense_Mutation_p.F464L|ZNF92_ENST00000431504.1_Missense_Mutation_p.F420L	NM_152626.2	NP_689839.1	Q03936	ZNF92_HUMAN	zinc finger protein 92	496						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|skin(1)|stomach(1)	13		Lung NSC(55;0.159)				CCTCAATTTTTACTAAACATA	0.338000													27	31					0	0	1	0	0
SLFN12	55106	broad.mit.edu	37	17	33738475	33738475	+	Missense_Mutation	SNP	C	C	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:33738475C>G	ENST00000394562.1	-	6	2142	c.1619G>C	c.(1618-1620)aGa>aCa	p.R540T	SLFN12_ENST00000452764.3_Missense_Mutation_p.R540T|SLFN12_ENST00000460530.1_5'UTR|SLFN12_ENST00000304905.5_Missense_Mutation_p.R540T			Q8IYM2	SLN12_HUMAN	schlafen family member 12	540							ATP binding			breast(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGACTTGAGTCTCTTTAAGGC	0.348000													38	52					0	0	1	0	0
TBC1D10C	374403	broad.mit.edu	37	11	67171788	67171788	+	Missense_Mutation	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:67171788C>A	ENST00000312390.5	+	2	144	c.115C>A	c.(115-117)Cgc>Agc	p.R39S	TBC1D10C_ENST00000542590.1_Missense_Mutation_p.R39S|TBC1D10C_ENST00000526387.1_Missense_Mutation_p.R39S	NM_198517.3	NP_940919.1	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	39						intracellular	Rab GTPase activator activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CCAGGCCGACCGCTATGGATT	0.667000													23	27					1.66031e-10	1.6689e-10	1	1	0
CCDC158	339965	broad.mit.edu	37	4	77317509	77317509	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:77317509G>A	ENST00000388914.3	-	3	353	c.201C>T	c.(199-201)atC>atT	p.I67I	CCDC158_ENST00000504868.1_5'UTR|CCDC158_ENST00000434846.2_Silent_p.I67I	NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	67										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						GAGATGGGATGATTTTTCTAG	0.373000													39	52					0	0	1	0	0
ASH2L	9070	broad.mit.edu	37	8	37985811	37985811	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:37985811C>T	ENST00000343823.6	+	11	1477	c.1168C>T	c.(1168-1170)Ccc>Tcc	p.P390S	ASH2L_ENST00000428278.2_Missense_Mutation_p.P296S|ASH2L_ENST00000250635.7_Missense_Mutation_p.P296S|ASH2L_ENST00000521652.1_Missense_Mutation_p.P296S|ASH2L_ENST00000545394.1_Missense_Mutation_p.P251S	NM_004674.4	NP_004665.2	Q9UBL3	ASH2L_HUMAN	ash2 (absent, small, or homeotic)-like (Drosophila)	390	B30.2/SPRY.				hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|stomach(1)	19	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				CACCGCAGCTCCCCAGTTAAA	0.448000													17	2					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100170018	100170018	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:100170018G>A	ENST00000524871.1	+	20	2800	c.2510G>A	c.(2509-2511)cGa>cAa	p.R837Q	CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000528682.1_Missense_Mutation_p.R837Q|CNTN5_ENST00000279463.3_Missense_Mutation_p.R837Q|CNTN5_ENST00000418526.2_Missense_Mutation_p.R763Q|CNTN5_ENST00000527185.1_Missense_Mutation_p.R837Q	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	837	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding	p.R837Q(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TTCATTTATCGAGATGAAAGT	0.433000													30	45					0	0	1	0	0
LMTK2	22853	broad.mit.edu	37	7	97822244	97822244	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:97822244G>A	ENST00000297293.5	+	11	2760	c.2467G>A	c.(2467-2469)Gaa>Aaa	p.E823K		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	823					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CTTCGAAACAGAAGAAACGCC	0.542000													66	98					0	0	1	0	0
CDR1	1038	broad.mit.edu	37	X	139866349	139866349	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:139866349C>T	ENST00000370532.2	-	1	374	c.183G>A	c.(181-183)acG>acA	p.T61T		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	61	23 X 6 AA approximate repeats.									breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CCAGGAAATCCGTGTCTTCCA	0.443000													76	13					0	0	1	0	0
HERC3	8916	broad.mit.edu	37	4	89597509	89597509	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:89597509C>T	ENST00000402738.1	+	18	2199	c.1960C>T	c.(1960-1962)Cct>Tct	p.P654S	HERC3_ENST00000543130.1_Missense_Mutation_p.P98S|HERC3_ENST00000264345.3_Missense_Mutation_p.P654S	NM_001271602.1|NM_014606.1	NP_001258531.1|NP_055421.1	Q15034	HERC3_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 3	654					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|prostate(2)|skin(2)	45				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		TTGTTCCTACCCTTTCATCTT	0.318000													33	60					0	0	1	0	0
SUPT16H	11198	broad.mit.edu	37	14	21837440	21837440	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:21837440G>A	ENST00000216297.2	-	6	1043	c.705C>T	c.(703-705)gaC>gaT	p.D235D		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	235					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CAGTAGAAGGGTCTGCCCCAG	0.418000													39	30					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906263	164906263	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:164906263C>T	ENST00000475390.1	-	2	2799	c.2356G>A	c.(2356-2358)Gga>Aga	p.G786R	SLITRK3_ENST00000241274.3_Missense_Mutation_p.G786R			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	786						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						TCACCCATTCCCGGTGGTTGT	0.562000										HNSCC(40;0.11)			61	66					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62289219	62289219	+	Missense_Mutation	SNP	G	G	A	rs143211270	by1000genomes	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:62289219G>A	ENST00000519846.1	+	4	983	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K	CLVS1_ENST00000518592.1_5'UTR|CLVS1_ENST00000325897.4_Missense_Mutation_p.E171K			Q8IUQ0	CLVS1_HUMAN	clavesin 1	171	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity	p.E171K(1)		endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						AGTCCTAATCGAAGATCCGGA	0.438000													64	78					0	0	1	0	0
FFAR3	2865	broad.mit.edu	37	19	35849909	35849909	+	Silent	SNP	C	C	T	rs148149328		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:35849909C>T	ENST00000327809.4	+	2	318	c.117C>T	c.(115-117)ttC>ttT	p.F39F	FFAR3_ENST00000594310.1_Silent_p.F39F	NM_005304.3	NP_005295.1	O14843	FFAR3_HUMAN	free fatty acid receptor 3	39						integral to plasma membrane	G-protein coupled receptor activity|lipid binding	p.F39F(1)		endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|stomach(1)	17	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			TGGTGGTCTTCGTGGGCAAGC	0.637000													68	256					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55889948	55889948	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:55889948C>T	ENST00000313472.3	+	1	100	c.100C>T	c.(100-102)Ctc>Ttc	p.L34F		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L34I(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					GCTATTTCTCCTCATATACCT	0.453000													114	147					0	0	1	0	0
PIGV	55650	broad.mit.edu	37	1	27121213	27121213	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:27121213C>T	ENST00000374145.1	+	3	1370	c.688C>T	c.(688-690)Cct>Tct	p.P230S	PIGV_ENST00000078527.4_Missense_Mutation_p.P230S|PIGV_ENST00000449950.2_Intron	NM_001202554.1	NP_001189483.1	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class V	230					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	14		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		GATGCTGAATCCTCTGAGACA	0.498000													58	83					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890376	229890376	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:229890376G>A	ENST00000392054.3	-	4	1058	c.719C>T	c.(718-720)tCc>tTc	p.S240F	PID1_ENST00000482518.2_Intron|PID1_ENST00000392055.3_Missense_Mutation_p.S209F|PID1_ENST00000409462.1_Missense_Mutation_p.S160F|PID1_ENST00000354069.6_Missense_Mutation_p.S242F	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	242	PID.					cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		CAATTCCTGGGAAACCTCTTC	0.512000													42	104					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40770556	40770556	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:40770556G>A	ENST00000373198.3	-	19	3070	c.2836_splice	c.e19+1	p.S945_splice	PTPRT_ENST00000373190.1_Splice_Site_p.S922_splice|PTPRT_ENST00000373187.1_Splice_Site_p.S923_splice|PTPRT_ENST00000373201.1_Splice_Site_p.S913_splice|PTPRT_ENST00000373184.1_Splice_Site_p.S913_splice|PTPRT_ENST00000356100.2_Splice_Site_p.S932_splice|PTPRT_ENST00000373193.3_Splice_Site_p.S926_splice	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	923	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGCACCTACAGGATATGATGT	0.453000													74	111					0	0	1	0	0
ARID3C	138715	broad.mit.edu	37	9	34623571	34623571	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:34623571C>T	ENST00000378909.2	-	4	808	c.716G>A	c.(715-717)gGg>gAg	p.G239E		NM_001017363.1	NP_001017363.1	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT-like)	239					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	14	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		AGGGGGCGGCCCTGCCAAGCC	0.746000													20	6					0	0	1	0	0
SLC18A1	6570	broad.mit.edu	37	8	20022394	20022394	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:20022394G>A	ENST00000440926.1	-	11	1471	c.1001C>T	c.(1000-1002)cCc>cTc	p.P334L	SLC18A1_ENST00000265808.7_Intron|SLC18A1_ENST00000276373.5_Missense_Mutation_p.P334L|SLC18A1_ENST00000381608.4_Missense_Mutation_p.P334L|SLC18A1_ENST00000519026.1_Intron|SLC18A1_ENST00000437980.1_Missense_Mutation_p.P334L	NM_001135691.2	NP_001129163.1	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 1	334					neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29				Colorectal(74;0.0747)		CTGCCACTTGGGGGAGCACAT	0.602000													31	4					0	0	1	0	0
CYP7B1	9420	broad.mit.edu	37	8	65527784	65527784	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:65527784G>A	ENST00000310193.3	-	4	1029	c.856C>T	c.(856-858)Cat>Tat	p.H286Y	CYP7B1_ENST00000523954.1_5'UTR	NM_004820.3	NP_004811.1	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B, polypeptide 1	286					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				AAGCCTAAATGATGTGCTGGG	0.423000													22	24					0	0	1	0	0
AHRR	57491	broad.mit.edu	37	5	428049	428049	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:428049C>T	ENST00000316418.5	+	9	946	c.902C>T	c.(901-903)gCg>gTg	p.A301V	AHRR_ENST00000505113.1_Missense_Mutation_p.A283V|AHRR_ENST00000506456.1_Missense_Mutation_p.A139V|AHRR_ENST00000512529.1_Missense_Mutation_p.A129V	NM_020731.4	NP_065782.2	A9YTQ3	AHRR_HUMAN	aryl-hydrocarbon receptor repressor	283					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity	p.A297V(1)		breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			CCCTCCGCAGCGGAGATGAAA	0.617000													10	14					0	0	1	0	0
SMYD1	150572	broad.mit.edu	37	2	88390598	88390598	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:88390598C>T	ENST00000419482.2	+	4	681	c.596C>T	c.(595-597)cCc>cTc	p.P199L	SMYD1_ENST00000444564.2_Missense_Mutation_p.P199L|SMYD1_ENST00000438570.1_Intron	NM_198274.3	NP_938015.1	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	199	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	41						GGCATCTTCCCCAACCTGGGC	0.507000													81	83					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114379241	114379241	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:114379241C>T	ENST00000312719.5	-	5	1409	c.221G>A	c.(220-222)gGc>gAc	p.G74D	RP3-399L15.3_ENST00000523087.1_RNA|RP3-399L15.3_ENST00000519104.1_RNA|RP3-399L15.3_ENST00000519270.1_RNA|HS3ST5_ENST00000411826.1_Missense_Mutation_p.G74D			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	74					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding	p.G74V(1)		breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GGAAGCGTTGCCCTTCCGGAA	0.607000													14	33					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906264	164906264	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:164906264C>T	ENST00000475390.1	-	2	2798	c.2355G>A	c.(2353-2355)ccG>ccA	p.P785P	SLITRK3_ENST00000241274.3_Silent_p.P785P			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	785						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CACCCATTCCCGGTGGTTGTG	0.557000										HNSCC(40;0.11)			61	67					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7568235	7568235	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:7568235C>T	ENST00000340209.4	+	2	426	c.129C>T	c.(127-129)ccC>ccT	p.P43P	RBFOX1_ENST00000355637.4_Silent_p.P58P|RBFOX1_ENST00000422070.4_Silent_p.P81P|RBFOX1_ENST00000550418.1_Silent_p.P38P|RBFOX1_ENST00000547338.1_Silent_p.P38P|RBFOX1_ENST00000436368.2_Silent_p.P58P|RBFOX1_ENST00000311745.5_Silent_p.P58P|RBFOX1_ENST00000553186.1_Silent_p.P38P|RBFOX1_ENST00000535565.2_Silent_p.P74P|RBFOX1_ENST00000547372.1_Silent_p.P81P|RBFOX1_ENST00000552089.1_Silent_p.P74P			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	38					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						ACGGTATCCCCGCGGAATACA	0.607000													103	83					0	0	1	0	0
PITX1	5307	broad.mit.edu	37	5	134364829	134364829	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:134364829G>A	ENST00000265340.7	-	3	1001	c.585C>T	c.(583-585)tcC>tcT	p.S195S	PITX1_ENST00000506438.1_Silent_p.S195S	NM_002653.4	NP_002644.4	P78337	PITX1_HUMAN	paired-like homeodomain 1	195	Interacts with PIT-1 (By similarity).					nucleolus	sequence-specific DNA binding			central_nervous_system(1)|cervix(3)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	READ - Rectum adenocarcinoma(2;0.0607)		AGCTCTTGGTGGAGAGCGGCG	0.627000													24	41					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31600107	31600107	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:31600107C>T	ENST00000376033.2	+	16	3891	c.3657C>T	c.(3655-3657)tcC>tcT	p.S1219S	PRRC2A_ENST00000376007.4_Silent_p.S1219S	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	1219	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						GGCCTCTGTCCCCTGTGGCGC	0.607000													13	48					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898910	36898910	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:36898910C>T	ENST00000301807.6	-	12	2418	c.521G>A	c.(520-522)gGa>gAa	p.G174E	TRANK1_ENST00000429976.2_Missense_Mutation_p.G724E|TRANK1_ENST00000428977.2_Missense_Mutation_p.G174E	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	724					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						ATCTTTCTTTCCTTCTTTGCC	0.562000													43	56					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10080284	10080284	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:10080284C>T	ENST00000264828.3	-	56	4150	c.4065G>A	c.(4063-4065)ggG>ggA	p.G1355G		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1355	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GACCCTCAGGCCCCACACGTC	0.677000													8	29					0	0	1	0	0
SEMG2	6407	broad.mit.edu	37	20	43851810	43851810	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:43851810C>T	ENST00000372769.3	+	2	1627	c.1537C>T	c.(1537-1539)Cct>Tct	p.P513S		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	513	Repeat-rich region.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				GACACCAAATCCTAATCAAGA	0.403000													43	37					0	0	1	0	0
FAM49B	51571	broad.mit.edu	37	8	130864455	130864455	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:130864455G>A	ENST00000519824.2	-	8	859	c.586C>T	c.(586-588)Cca>Tca	p.P196S	FAM49B_ENST00000522250.1_Missense_Mutation_p.P50S|FAM49B_ENST00000522941.1_Missense_Mutation_p.P50S|FAM49B_ENST00000519540.1_Missense_Mutation_p.P196S|FAM49B_ENST00000517654.1_Missense_Mutation_p.P196S|FAM49B_ENST00000522746.1_Missense_Mutation_p.P196S|FAM49B_ENST00000401979.2_Missense_Mutation_p.P196S|FAM49B_ENST00000519110.1_Missense_Mutation_p.P196S|FAM49B_ENST00000523509.1_Missense_Mutation_p.P196S	NM_016623.4	NP_057707.3	Q9NUQ9	FA49B_HUMAN	family with sequence similarity 49, member B	196										kidney(1)|large_intestine(6)|lung(4)|prostate(1)	12	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			TTCAGCATTGGAGTTGCCTCA	0.413000													55	60					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228128574	228128574	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:228128574G>A	ENST00000396578.3	+	21	1391	c.1229G>A	c.(1228-1230)gGa>gAa	p.G410E	AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000437673.1_RNA|AC097662.2_ENST00000396588.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	410	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGCCGCCCAGGAAAGGATGCC	0.572000													33	74					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24835074	24835074	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:24835074G>A	ENST00000376454.3	+	21	5683	c.5653G>A	c.(5653-5655)Ggc>Agc	p.G1885S	KIAA1217_ENST00000376451.2_3'UTR|KIAA1217_ENST00000376452.3_Missense_Mutation_p.G1316S|KIAA1217_ENST00000376462.1_Missense_Mutation_p.G1206S|KIAA1217_ENST00000396445.1_3'UTR|KIAA1217_ENST00000458595.1_Missense_Mutation_p.G1291S	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	1885	Ser-rich.				embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						GAGTCAAAATGGCCGAGCAcc	0.522000													45	12					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179504007	179504007	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:179504007C>T	ENST00000367618.3	+	25	3328	c.2941C>T	c.(2941-2943)Caa>Taa	p.Q981*		NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	981	Glu-rich.									NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						gaaagaaaatcaagatgaaag	0.328000													25	35					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35965804	35965804	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:35965804C>T	ENST00000274278.3	-	4	884	c.527G>A	c.(526-528)gGg>gAg	p.G176E	UGT3A1_ENST00000507113.1_Missense_Mutation_p.G142E|UGT3A1_ENST00000503189.1_Missense_Mutation_p.G176E|UGT3A1_ENST00000513233.1_Intron|UGT3A1_ENST00000333811.4_Missense_Mutation_p.G122E	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	176						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCTTGGTAGCCCAAAATCCAA	0.438000													12	44					0	0	1	0	0
USP53	54532	broad.mit.edu	37	4	120193171	120193171	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:120193171A>G	ENST00000450251.1	+	12	2700	c.2156A>G	c.(2155-2157)aAa>aGa	p.K719R	USP53_ENST00000274030.6_Missense_Mutation_p.K719R			Q70EK8	UBP53_HUMAN	ubiquitin specific peptidase 53	719					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	27						AGTGGTGTTAAAGAAACAGTA	0.343000													36	81					0	0	1	0	0
TSPAN32	10077	broad.mit.edu	37	11	2338704	2338704	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:2338704G>A	ENST00000182290.4	+	9	987	c.850G>A	c.(850-852)Gag>Aag	p.E284K	TSPAN32_ENST00000451520.2_Missense_Mutation_p.E273K|TSPAN32_ENST00000381121.3_Intron	NM_139022.2	NP_620591.3	Q96QS1	TSN32_HUMAN	tetraspanin 32	284					cell-cell signaling	integral to membrane				breast(1)|central_nervous_system(1)|lung(4)|ovary(1)|skin(1)	8		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		GTGGCTGCAGGAGAGCGATGC	0.622000													12	11					0	0	1	0	0
GDF3	9573	broad.mit.edu	37	12	7848234	7848234	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:7848234G>A	ENST00000329913.3	-	1	138	c.91C>T	c.(91-93)Caa>Taa	p.Q31*		NM_020634.1	NP_065685.1	Q9NR23	GDF3_HUMAN	growth differentiation factor 3	31					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						CCCAGAAATTGGAGAAAGACA	0.478000													14	24					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771783	143771783	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:143771783C>T	ENST00000408898.2	+	1	509	c.471C>T	c.(469-471)gtC>gtT	p.V157V		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					TGGCCCTTGTCCATCTAGTGT	0.453000													86	105					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36938934	36938934	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:36938934C>T	ENST00000262865.4	+	4	517	c.428C>T	c.(427-429)tCc>tTc	p.S143F	CTD-2308N23.2_ENST00000437016.1_RNA	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	143					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				GAAGGCATGTCCATTTCGGCT	0.507000													37	51					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113295346	113295346	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:113295346C>T	ENST00000362072.3	-	2	372	c.28G>A	c.(28-30)Gat>Aat	p.D10N	DRD2_ENST00000542968.1_Missense_Mutation_p.D10N|DRD2_ENST00000346454.3_Missense_Mutation_p.D10N|DRD2_ENST00000544518.1_Missense_Mutation_p.D10N|DRD2_ENST00000538967.1_Missense_Mutation_p.D10N|DRD2_ENST00000355319.2_Missense_Mutation_p.D10N	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	10					activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	AGATCATCATCATACCAGGAC	0.582000													41	45					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589520	140589520	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:140589520C>T	ENST00000239450.2	+	1	1230	c.1041C>T	c.(1039-1041)atC>atT	p.I347I	PCDHB12_ENST00000541609.1_Silent_p.I10I	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		347	Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCTGAAATCACTGTGTCAT	0.438000													43	24					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95481750	95481750	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:95481750C>T	ENST00000432432.2	-	0	1610					NR_040113.1																						TTATGAAAATCCTAAATAAAA	0.303000													52	103					0	0	1	0	0
ZFX	7543	broad.mit.edu	37	X	24228975	24228975	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:24228975C>T	ENST00000379177.1	+	11	2327	c.1900C>T	c.(1900-1902)Cag>Tag	p.Q634*	ZFX_ENST00000338565.3_Nonsense_Mutation_p.Q584*|ZFX_ENST00000540034.1_Nonsense_Mutation_p.Q673*|ZFX_ENST00000539115.1_Nonsense_Mutation_p.Q405*|ZFX_ENST00000379188.3_Nonsense_Mutation_p.Q634*|ZFX_ENST00000304543.5_Nonsense_Mutation_p.Q634*	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	634				Missing (in Ref. 5).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						CAAAACACACCAGTGTTTGCA	0.423000													73	10					0	0	1	0	0
PRELP	5549	broad.mit.edu	37	1	203453155	203453155	+	Missense_Mutation	SNP	G	G	T	rs146499921	by1000genomes	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:203453155G>T	ENST00000343110.2	+	2	970	c.843G>T	c.(841-843)agG>agT	p.R281S		NM_002725.3|NM_201348.1	NP_002716.1|NP_958505.1	P51888	PRELP_HUMAN	proline/arginine-rich end leucine-rich repeat protein	281					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			BRCA - Breast invasive adenocarcinoma(75;0.109)			TGACAGACAGGGGACTCCCCA	0.498000													50	71					1.02067e-35	1.03805e-35	1	1	0
CCDC63	160762	broad.mit.edu	37	12	111342456	111342456	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:111342456G>A	ENST00000308208.5	+	11	1649	c.1407G>A	c.(1405-1407)gtG>gtA	p.V469V	CCDC63_ENST00000552694.1_Silent_p.V390V|CCDC63_ENST00000545036.1_Silent_p.V429V	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	469										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						TCCTGGAAGTGGAAGGGGCAG	0.577000													31	62					0	0	1	0	0
ZNF525	170958	broad.mit.edu	37	19	53885228	53885228	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:53885228C>T	ENST00000467003.1	+	4	1489	c.1288C>T	c.(1288-1290)Cct>Tct	p.P430S	ZNF525_ENST00000475179.1_Intron|ZNF525_ENST00000593918.1_Intron|ZNF525_ENST00000355326.3_Missense_Mutation_p.P184S|ZNF525_ENST00000474037.1_Missense_Mutation_p.P466S					zinc finger protein 525											endometrium(3)|kidney(3)|lung(3)	9						TGGAGAGAAACCTTGCAAGTG	0.373000													17	21					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82816726	82816726	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:82816726G>A	ENST00000265077.3	+	7	3166	c.2601G>A	c.(2599-2601)gaG>gaA	p.E867E	VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Intron|VCAN_ENST00000342785.4_Silent_p.E867E|VCAN_ENST00000512590.2_Silent_p.E819E	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	867	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AGTTAGAGGAGGTTACTGATG	0.383000													43	88					0	0	1	0	0
SGK1	6446	broad.mit.edu	37	6	134491532	134491532	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:134491532G>A	ENST00000367858.5	-	14	2052	c.1455C>T	c.(1453-1455)acC>acT	p.T485T	SGK1_ENST00000475719.2_Silent_p.T346T|SGK1_ENST00000528577.1_Silent_p.T418T|SGK1_ENST00000367857.5_Silent_p.T380T|SGK1_ENST00000237305.7_Silent_p.T390T|SGK1_ENST00000413996.3_Silent_p.T404T	NM_001143676.1	NP_001137148.1	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1	390					apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(21)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(4)|stomach(1)	46	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		CAGGCTCTTCGGTAAACTCGG	0.557000													28	30					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58084492	58084492	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:58084492C>T	ENST00000357272.4	+	8	1367	c.1202C>T	c.(1201-1203)aCc>aTc	p.T401I	FLNB_ENST00000419752.2_Missense_Mutation_p.T232I|FLNB_ENST00000493452.1_Missense_Mutation_p.T232I|FLNB_ENST00000490882.1_Missense_Mutation_p.T401I|FLNB_ENST00000358537.3_Missense_Mutation_p.T401I|FLNB_ENST00000348383.5_Missense_Mutation_p.T401I|FLNB_ENST00000429972.2_Missense_Mutation_p.T401I|FLNB_ENST00000295956.4_Missense_Mutation_p.T401I			O75369	FLNB_HUMAN	filamin B, beta	401					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGGAAGAACACCGTGGAGTTG	0.532000													45	53					0	0	1	0	0
MLH1	4292	broad.mit.edu	37	3	37067303	37067303	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:37067303C>T	ENST00000231790.2	+	12	1430	c.1214C>T	c.(1213-1215)tCc>tTc	p.S405F	MLH1_ENST00000435176.1_Missense_Mutation_p.S307F|MLH1_ENST00000455445.2_Missense_Mutation_p.S164F|MLH1_ENST00000458205.2_Missense_Mutation_p.S164F|MLH1_ENST00000536378.1_Missense_Mutation_p.S164F|MLH1_ENST00000539477.1_Missense_Mutation_p.S164F	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	405					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						AAACCCCTGTCCAGTCAGCCC	0.522000		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				75	71					0	0	1	0	0
C5AR1	728	broad.mit.edu	37	19	47823172	47823172	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:47823172C>T	ENST00000355085.3	+	2	160	c.138C>T	c.(136-138)gtC>gtT	p.V46V		NM_001736.3	NP_001727.1	P21730	C5AR_HUMAN	complement component 5a receptor 1	46					activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity	p.V46V(1)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)	20		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		TCTTTGCAGTCGTCTTCCTGG	0.552000													43	60					0	0	1	0	0
PHKA1	5255	broad.mit.edu	37	X	71895930	71895930	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:71895930C>T	ENST00000373545.3	-	6	1046	c.608G>A	c.(607-609)gGa>gAa	p.G203E	PHKA1_ENST00000339490.3_Missense_Mutation_p.G203E|PHKA1_ENST00000541944.1_Missense_Mutation_p.G203E|PHKA1_ENST00000373539.3_Missense_Mutation_p.G203E|PHKA1_ENST00000373542.4_Missense_Mutation_p.G203E			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	203					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					CTTTGCCATTCCAACTGAACT	0.418000													31	3					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34881076	34881076	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:34881076C>T	ENST00000431794.3	-	6	919	c.397G>A	c.(397-399)Gag>Aag	p.E133K	MYO19_ENST00000544606.1_Intron|MYO19_ENST00000268852.9_Missense_Mutation_p.E133K|MYO19_ENST00000586007.1_Missense_Mutation_p.E133K	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	133	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GCACCACTCTCTCCACTGACA	0.527000													105	111					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91804390	91804390	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:91804390C>T	ENST00000389857.6	-	10	1095	c.1009G>A	c.(1009-1011)Gag>Aag	p.E337K		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	337					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TGCAGCTTCTCCTTGCAGCGG	0.627000													31	29					0	0	1	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24980025	24980025	+	Missense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:24980025A>T	ENST00000289968.6	-	5	410	c.341T>A	c.(340-342)tTt>tAt	p.F114Y	ARHGAP17_ENST00000303665.5_Missense_Mutation_p.F114Y|ARHGAP17_ENST00000575975.1_5'UTR|ARHGAP17_ENST00000441763.2_Missense_Mutation_p.F114Y	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	114	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		CTTCTCAACAAAGACTTCGTG	0.557000													58	81					0	0	1	0	0
SGK1	6446	broad.mit.edu	37	6	134491533	134491533	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:134491533G>A	ENST00000367858.5	-	14	2051	c.1454C>T	c.(1453-1455)aCc>aTc	p.T485I	SGK1_ENST00000475719.2_Missense_Mutation_p.T346I|SGK1_ENST00000528577.1_Missense_Mutation_p.T418I|SGK1_ENST00000367857.5_Missense_Mutation_p.T380I|SGK1_ENST00000237305.7_Missense_Mutation_p.T390I|SGK1_ENST00000413996.3_Missense_Mutation_p.T404I	NM_001143676.1	NP_001137148.1	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1	390					apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(21)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(4)|stomach(1)	46	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		AGGCTCTTCGGTAAACTCGGG	0.552000													29	30					0	0	1	0	0
SPEM1	374768	broad.mit.edu	37	17	7324546	7324546	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:7324546C>T	ENST00000323675.3	+	3	577	c.552C>T	c.(550-552)acC>acT	p.T184T	RP11-104H15.7_ENST00000575310.1_RNA	NM_199339.2	NP_955371.2	Q8N4L4	SPEM1_HUMAN	spermatid maturation 1	184					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	12		Prostate(122;0.173)				TCCAGCCTACCGTAGAGGAAA	0.612000													34	9					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68264870	68264870	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:68264870G>A	ENST00000347230.4	-	11	2247	c.2109C>T	c.(2107-2109)agC>agT	p.S703S	ZFYVE26_ENST00000555452.1_Silent_p.S703S	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	703					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TCTCAGGAGGGCTGCGGCTAC	0.522000													40	21					0	0	1	0	0
SPERT	220082	broad.mit.edu	37	13	46287415	46287415	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:46287415G>A	ENST00000378966.3	+	2	563	c.147G>A	c.(145-147)gcG>gcA	p.A49A	SPERT_ENST00000310521.1_Silent_p.A85A			Q8NA61	SPERT_HUMAN	spermatid associated	85						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		GCAGGATGGCGAGCCAGCACT	0.672000													23	104					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30977214	30977214	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:30977214C>T	ENST00000295055.8	-	9	1059	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K	CAPN13_ENST00000534090.2_Missense_Mutation_p.E295K	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	295	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TCACAGGTTTCCTCCCACTCC	0.448000													10	9					0	0	1	0	0
RORC	6097	broad.mit.edu	37	1	151789199	151789199	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:151789199C>T	ENST00000356728.6	-	3	330	c.176G>A	c.(175-177)cGa>cAa	p.R59Q	RORC_ENST00000318247.6_Missense_Mutation_p.R80Q|RORC_ENST00000392697.3_Missense_Mutation_p.R134Q	NM_001001523.1	NP_001001523.1	P51449	RORG_HUMAN	RAR-related orphan receptor C	80					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCATCGGTTTCGGCTGGTGCG	0.652000													9	7					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152644623	152644623	+	Missense_Mutation	SNP	G	G	A	rs149215868		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:152644623G>A	ENST00000367255.5	-	82	16508	c.15907C>T	c.(15907-15909)Cgg>Tgg	p.R5303W	SYNE1_ENST00000265368.4_Missense_Mutation_p.R5303W|SYNE1_ENST00000423061.1_Missense_Mutation_p.R5232W|SYNE1_ENST00000341594.5_Missense_Mutation_p.R4996W|SYNE1_ENST00000448038.1_Missense_Mutation_p.R5232W	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5303					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCAGGCACCGATCTTGCATG	0.537000										HNSCC(10;0.0054)			32	31					0	0	1	0	0
ZC3H12A	80149	broad.mit.edu	37	1	37949106	37949106	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:37949106C>T	ENST00000373087.6	+	6	1810	c.1694C>T	c.(1693-1695)cCc>cTc	p.P565L		NM_025079.2	NP_079355.2	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	565					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGTGTGTTTCCCCCGCACCTG	0.667000													43	46					0	0	1	0	0
PLA1A	51365	broad.mit.edu	37	3	119328347	119328347	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:119328347C>T	ENST00000273371.4	+	4	558	c.486C>T	c.(484-486)atC>atT	p.I162I	PLA1A_ENST00000494440.1_Silent_p.I146I|PLA1A_ENST00000488919.1_5'UTR|PLA1A_ENST00000495992.1_Silent_p.I146I	NM_015900.3	NP_056984.1	Q53H76	PLA1A_HUMAN	phospholipase A1 member A	162					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CAATCCACATCATTGGTGTTA	0.587000													61	78					0	0	1	0	0
SCAP	22937	broad.mit.edu	37	3	47470067	47470067	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:47470067G>A	ENST00000265565.5	-	4	758	c.346C>T	c.(346-348)Cgt>Tgt	p.R116C	SCAP_ENST00000545718.1_Intron|SCAP_ENST00000441517.2_Intron	NM_012235.2	NP_036367.2	Q12770	SCAP_HUMAN	SREBF chaperone	116					cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	26				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		AAAGGTGAACGAAATACATCT	0.557000													68	98					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118753067	118753067	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:118753067G>A	ENST00000376300.2	-	6	611	c.474C>T	c.(472-474)ttC>ttT	p.F158F	CCDC93_ENST00000319432.5_Silent_p.F158F|CCDC93_ENST00000460781.1_5'UTR	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	158										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						TTCTCTTTATGAAGTCATCAT	0.423000													51	56					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196799458	196799458	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:196799458C>T	ENST00000312428.6	-	21	3428	c.3328G>A	c.(3328-3330)Gaa>Aaa	p.E1110K		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1110	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCTAAAGTTTCCGTAAATTCT	0.378000													75	46					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86468435	86468435	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:86468435A>G	ENST00000361669.2	+	4	2704	c.1605A>G	c.(1603-1605)gaA>gaG	p.E535E	GRM3_ENST00000546348.1_Silent_p.E127E|GRM3_ENST00000536043.1_Silent_p.E407E|GRM3_ENST00000394720.2_Intron|GRM3_ENST00000439827.1_Intron	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	535					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TCCCCTGTGAACCCTACGAAT	0.532000													67	94					0	0	1	0	0
TTC37	9652	broad.mit.edu	37	5	94820512	94820512	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:94820512G>A	ENST00000358746.2	-	38	4267	c.3969C>T	c.(3967-3969)tcC>tcT	p.S1323S		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1323							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						ACTTTTCAAGGGACTGGTTGT	0.343000													40	37					0	0	1	0	0
CFAP221	200373	broad.mit.edu	37	2	120362840	120362840	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:120362840G>A	ENST00000602047.1	+	12	1362	c.250G>A	c.(250-252)Gaa>Aaa	p.E84K	PCDP1_ENST00000597189.1_3'UTR|PCDP1_ENST00000413369.3_Missense_Mutation_p.E370K			Q4G0U5	PCDP1_HUMAN		370						cilium	calmodulin binding					Colorectal(110;0.196)					GGACATTCACGAAGAGATGGA	0.378000													26	33					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58711097	58711097	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:58711097C>T	ENST00000300079.5	+	2	156	c.106C>T	c.(106-108)Cca>Tca	p.P36S	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_5'UTR	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	0						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	cctgcaggatccaattgtgtc	0.468000													22	40					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49168499	49168499	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:49168499G>A	ENST00000418109.1	-	8	963	c.799C>T	c.(799-801)Cga>Tga	p.R267*	LAMB2_ENST00000305544.4_Nonsense_Mutation_p.R267*	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	267	Laminin N-terminal.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TACTTCTCTCGGATCTCCCTC	0.582000													47	57					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103471423	103471423	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:103471423G>A	ENST00000358392.2	-	18	2169	c.1852C>T	c.(1852-1854)Ccg>Tcg	p.P618S	COL11A1_ENST00000461720.1_5'UTR|COL11A1_ENST00000353414.4_Missense_Mutation_p.P567S|COL11A1_ENST00000512756.1_Missense_Mutation_p.P490S|COL11A1_ENST00000370096.3_Missense_Mutation_p.P606S	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	606	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGCAGACCCGGAAGTCCATCA	0.363000													52	74					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18524145	18524145	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:18524145C>T	ENST00000433979.1	+	12	1773	c.1657C>T	c.(1657-1659)Cca>Tca	p.P553S	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.P553S|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.P594S	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	553					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				AAAGTCACTTCCAAGGGAATC	0.368000													6	8					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18376202	18376202	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:18376202C>T	ENST00000392413.3	-	3	2363	c.2148G>A	c.(2146-2148)atG>atA	p.M716I	KIAA1683_ENST00000600328.2_Missense_Mutation_p.M716I|KIAA1683_ENST00000600359.2_Missense_Mutation_p.M670I	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	716						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						TCTGGGAATGCATCTTGCTCA	0.627000													41	52					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4772483	4772483	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:4772483C>T	ENST00000378191.4	+	2	934	c.553C>T	c.(553-555)Ccc>Tcc	p.P185S	AJAP1_ENST00000378190.3_Missense_Mutation_p.P185S	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	185	Thr-rich.				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CGCCTGGGGGCCCACGGGGGA	0.652000													13	5					0	0	1	0	0
PDILT	204474	broad.mit.edu	37	16	20384393	20384393	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:20384393C>T	ENST00000302451.4	-	6	981	c.733G>A	c.(733-735)Gaa>Aaa	p.E245K		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	245					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						CGATTGAGTTCCTGTTTGTTG	0.423000													35	81					0	0	1	0	0
ABTB1	80325	broad.mit.edu	37	3	127395238	127395238	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:127395238G>A	ENST00000468137.1	+	4	634	c.18G>A	c.(16-18)tgG>tgA	p.W6*	ABTB1_ENST00000453791.2_Nonsense_Mutation_p.W6*|ABTB1_ENST00000232744.8_Nonsense_Mutation_p.W148*|ABTB1_ENST00000393363.3_Nonsense_Mutation_p.W6*			Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	148						cytoplasm|nucleolus|plasma membrane	translation elongation factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	10						ACACCAAATGGAAGGGCAAGA	0.577000													45	58					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41652581	41652581	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:41652581G>A	ENST00000313860.7	+	13	1891	c.1837G>A	c.(1837-1839)Gag>Aag	p.E613K	LIMCH1_ENST00000381753.4_Missense_Mutation_p.E447K|LIMCH1_ENST00000514096.1_Missense_Mutation_p.E454K|LIMCH1_ENST00000503057.1_Missense_Mutation_p.E998K|LIMCH1_ENST00000512946.1_Missense_Mutation_p.E613K|LIMCH1_ENST00000509277.1_Missense_Mutation_p.E447K|LIMCH1_ENST00000508501.1_Missense_Mutation_p.E613K|LIMCH1_ENST00000396595.3_Missense_Mutation_p.E459K|LIMCH1_ENST00000512820.1_Missense_Mutation_p.E601K|LIMCH1_ENST00000512632.1_Missense_Mutation_p.E613K|LIMCH1_ENST00000511496.1_Missense_Mutation_p.E454K|LIMCH1_ENST00000513024.1_Missense_Mutation_p.E442K	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	613					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						CGGTAGCATCGAGATCAACAT	0.502000													24	23					0	0	1	0	0
KCNJ10	3766	broad.mit.edu	37	1	160011957	160011957	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:160011957G>A	ENST00000368089.3	-	2	592	c.366C>T	c.(364-366)tcC>tcT	p.S122S	KCNJ10_ENST00000509700.1_5'UTR	NM_002241.4	NP_002232.2	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 10	122						integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)	17	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGGATTCAAGGGAGAAGAGGA	0.577000													43	75					0	0	1	0	0
LRRFIP2	9209	broad.mit.edu	37	3	37190414	37190414	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:37190414C>T	ENST00000421307.1	-	3	483	c.61G>A	c.(61-63)Gat>Aat	p.D21N	LRRFIP2_ENST00000354379.4_Missense_Mutation_p.D21N|LRRFIP2_ENST00000336686.4_Missense_Mutation_p.D21N|LRRFIP2_ENST00000421276.2_Missense_Mutation_p.D21N|LRRFIP2_ENST00000396428.2_Missense_Mutation_p.D21N|LRRFIP2_ENST00000440230.1_Missense_Mutation_p.D21N	NM_006309.2	NP_006300.1	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting protein 2	21	DVL3-binding.				Wnt receptor signaling pathway		LRR domain binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						AAAGCTTCATCTTCTGCAGAA	0.393000													49	66					0	0	1	0	0
USP17L2	377630	broad.mit.edu	37	8	11994905	11994905	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:11994905G>A	ENST00000333796.3	-	1	1681	c.1365C>T	c.(1363-1365)gtC>gtT	p.V455V	FAM66D_ENST00000434078.2_RNA	NM_001256869.1|NM_001256871.1|NM_001256872.1|NM_001256873.1|NM_001256874.1|NM_201402.2	NP_001243798.1|NP_001243800.1|NP_001243801.1|NP_001243802.1|NP_001243803.1|NP_958804.2	Q6R6M4	U17L2_HUMAN	ubiquitin specific peptidase 17-like family member 2	455					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(1)|kidney(1)|large_intestine(11)|liver(1)|lung(8)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	29						GGGTACCTTCGACTTTTCTGA	0.473000													37	98					0	0	1	0	0
OLFML2B	25903	broad.mit.edu	37	1	161989809	161989809	+	Missense_Mutation	SNP	G	G	A	rs142774017		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:161989809G>A	ENST00000294794.3	-	2	761	c.338C>T	c.(337-339)tCg>tTg	p.S113L	OLFML2B_ENST00000367940.2_Missense_Mutation_p.S113L	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	113										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			ACACTTGCACGACGAGCCTGA	0.617000													41	45					0	0	1	0	0
FAM198B	51313	broad.mit.edu	37	4	159091743	159091743	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:159091743G>A	ENST00000296530.8	-	2	1406	c.785C>T	c.(784-786)cCt>cTt	p.P262L	FAM198B_ENST00000589306.1_Intron|FAM198B_ENST00000585682.1_Missense_Mutation_p.P262L|FAM198B_ENST00000592057.1_Missense_Mutation_p.P262L|FAM198B_ENST00000393807.5_Missense_Mutation_p.P262L	NM_016613.6	NP_057697.2	Q6UWH4	F198B_HUMAN	family with sequence similarity 198, member B	262						Golgi membrane|integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(14)|skin(2)|urinary_tract(1)	26						ACAGGGGCTAGGGCCACAGCG	0.657000											OREG0016378	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	55					0	0	1	0	0
FAM114A1	92689	broad.mit.edu	37	4	38907208	38907208	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:38907208G>A	ENST00000358869.2	+	5	678	c.502G>A	c.(502-504)Gga>Aga	p.G168R	FAM114A1_ENST00000515037.1_5'UTR	NM_138389.2	NP_612398.2	Q8IWE2	NXP20_HUMAN	family with sequence similarity 114, member A1	168						cytoplasm				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	20						TGTAAATTCTGGATCTTCTGA	0.433000													66	78					0	0	1	0	0
ATF4P4	100127952	broad.mit.edu	37	11	113660285	113660285	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:113660285G>A	ENST00000393544.2	+	0	333																											CCACCAGAAGGAGCTAGGCAA	0.617000													17	20					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132498056	132498056	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:132498056C>T	ENST00000333577.4	+	19	3850	c.3741C>T	c.(3739-3741)atC>atT	p.I1247I	EP400_ENST00000389561.2_Silent_p.I1211I|EP400_ENST00000389562.2_Silent_p.I1210I|EP400_ENST00000332482.4_Silent_p.I1174I|EP400_ENST00000330386.6_Silent_p.I1211I			Q96L91	EP400_HUMAN	E1A binding protein p400	1247	Helicase ATP-binding.|Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TGCTTCTGATCGACTCGCCGC	0.582000													22	64					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48349628	48349628	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:48349628G>A	ENST00000435803.1	+	24	9430	c.9406G>A	c.(9406-9408)Gaa>Aaa	p.E3136K		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3136					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TCCCAAAGGGGAAAAATCTTG	0.483000													74	97					0	0	1	0	0
DOHH	83475	broad.mit.edu	37	19	3492321	3492321	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:3492321G>A	ENST00000427575.1	-	4	979	c.528C>T	c.(526-528)taC>taT	p.Y176Y	DOHH_ENST00000250937.3_Silent_p.Y176Y	NM_001145165.1	NP_001138637.1	Q9BU89	DOHH_HUMAN	deoxyhypusine hydroxylase/monooxygenase	176					peptidyl-lysine modification to hypusine|post-translational protein modification	cytosol	deoxyhypusine monooxygenase activity|metal ion binding|protein binding			central_nervous_system(1)|large_intestine(1)|lung(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		ACATGGCGCGGTATCGCTCGA	0.741000													10	6					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103861	53103861	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:53103861C>T	ENST00000408890.4	+	1	513	c.497C>T	c.(496-498)gCc>gTc	p.A166V		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	166										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						cgccccgccgcccAGGAGCTC	0.721000													11	12					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141740567	141740567	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:141740567C>T	ENST00000475668.2	+	21	2473	c.2419C>T	c.(2419-2421)Cct>Tct	p.P807S	MGAM_ENST00000549489.2_Missense_Mutation_p.P807S			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	807	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity	p.P807S(2)		cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GATGGAACTTCCTGGAGACAA	0.488000													21	19					0	0	1	0	0
TSHB	7252	broad.mit.edu	37	1	115576117	115576117	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:115576117C>T	ENST00000256592.1	+	2	202	c.134C>T	c.(133-135)aCc>aTc	p.T45I	TSHB_ENST00000369517.1_Missense_Mutation_p.T45I	NM_000549.3|NM_001277991.1	NP_000540.2|NP_001264920.1	P01222	TSHB_HUMAN	thyroid stimulating hormone, beta	45					anatomical structure morphogenesis|cell-cell signaling|cellular nitrogen compound metabolic process|G-protein coupled receptor protein signaling pathway|hormone biosynthetic process|peptide hormone processing	extracellular region	hormone activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7	Lung SC(450;0.211)	all_cancers(81;3.22e-07)|all_epithelial(167;1.4e-06)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		ATCAACACCACCATCTGTGCT	0.408000													55	103					0	0	1	0	0
LOC100631378	100631378	broad.mit.edu	37	19	38314532	38314532	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:38314532G>A	ENST00000592640.1	-	0	1545				CTD-2554C21.2_ENST00000590433.1_lincRNA	NR_040015.1																						GAAGAAAAAGGAAGATGGTGT	0.398000													13	8					0	0	1	0	0
ATP13A3	79572	broad.mit.edu	37	3	194147832	194147832	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:194147832A>G	ENST00000439040.1	-	29	3888	c.3097T>C	c.(3097-3099)Tgg>Cgg	p.W1033R	ATP13A3_ENST00000256031.4_Missense_Mutation_p.W1033R			Q9H7F0	AT133_HUMAN	ATPase type 13A3	1033					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		ACTTCATACCAAGGTTGCTGT	0.348000													29	42					0	0	1	0	0
OR2T10	127069	broad.mit.edu	37	1	248756846	248756846	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:248756846G>A	ENST00000330500.2	-	1	254	c.224C>T	c.(223-225)tCt>tTt	p.S75F		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GACAGTGACAGAAATATATGT	0.448000													27	2					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34620245	34620245	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:34620245G>A	ENST00000374789.3	-	19	2967	c.2642C>T	c.(2641-2643)tCc>tTc	p.S881F	PARD3_ENST00000374794.3_Missense_Mutation_p.S806F|PARD3_ENST00000374790.3_Missense_Mutation_p.S821F|PARD3_ENST00000374788.3_Missense_Mutation_p.S878F|PARD3_ENST00000374776.1_Missense_Mutation_p.S835F|PARD3_ENST00000544292.1_Missense_Mutation_p.S594F|PARD3_ENST00000346874.4_Missense_Mutation_p.S881F|PARD3_ENST00000350537.4_Missense_Mutation_p.S835F|PARD3_ENST00000374773.1_Missense_Mutation_p.S848F|PARD3_ENST00000545260.1_Missense_Mutation_p.S791F|PARD3_ENST00000545693.1_Missense_Mutation_p.S865F|PARD3_ENST00000340077.5_Missense_Mutation_p.S878F|PARD3_ENST00000466092.1_5'UTR	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	881	Interacts with PRKCZ (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding	p.P880_G883del(1)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				CAGACCCAGGGAAGGACCCAC	0.483000													38	8					0	0	1	0	0
OR4K14	122740	broad.mit.edu	37	14	20483167	20483167	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:20483167G>A	ENST00000305045.2	-	1	185	c.186C>T	c.(184-186)ttC>ttT	p.F62F		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TCCCCAGCAGGAAGTACATAG	0.468000													20	23					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103889	53103889	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:53103889G>A	ENST00000408890.4	+	1	541	c.525G>A	c.(523-525)cgG>cgA	p.R175R		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	175										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CCTGCACCCGGGAGACTCTGC	0.716000													15	15					0	0	1	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138200427	138200427	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:138200427T>C	ENST00000237289.4	+	7	1911	c.1845T>C	c.(1843-1845)ttT>ttC	p.F615F		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	615	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		GCGTGTATTTTGGGACTCCAG	0.547000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								46	37					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13735353	13735353	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:13735353G>A	ENST00000265104.4	-	68	11752	c.11648C>T	c.(11647-11649)gCt>gTt	p.A3883V		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3883					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCCTCGGGCAGCATACTTATA	0.443000									Kartagener syndrome				9	53					0	0	1	0	0
FOXJ3	22887	broad.mit.edu	37	1	42647663	42647663	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:42647663G>A	ENST00000372572.1	-	14	1989	c.1678C>T	c.(1678-1680)Cct>Tct	p.P560S	FOXJ3_ENST00000372571.1_Missense_Mutation_p.P74S|FOXJ3_ENST00000545068.1_Missense_Mutation_p.P560S|FOXJ3_ENST00000372573.1_Missense_Mutation_p.P560S|FOXJ3_ENST00000361776.1_Missense_Mutation_p.P526S|FOXJ3_ENST00000361346.1_Missense_Mutation_p.P560S	NM_001198851.1	NP_001185780.1	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	560					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ACTGAAGGAGGGAGATTTTGC	0.428000													16	21					0	0	1	0	0
ARSJ	79642	broad.mit.edu	37	4	114824378	114824378	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:114824378G>A	ENST00000315366.7	-	2	1718	c.852C>T	c.(850-852)tcC>tcT	p.S284S	ARSJ_ENST00000541197.1_Silent_p.S284S	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	284						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		TGTTGATAATGGATCGGTAGT	0.408000													60	75					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12124262	12124262	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:12124262C>T	ENST00000379388.2	+	4	4566	c.4234C>T	c.(4234-4236)Cga>Tga	p.R1412*		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1412					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TTCACCTTCTCGAGTGGGAGT	0.498000													60	94					0	0	1	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45885983	45885983	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:45885983G>A	ENST00000418234.2	-	12	2328	c.2248_splice	c.e12-1	p.D750_splice	PPP1R13L_ENST00000360957.5_Splice_Site_p.D750_splice	NM_001142502.1	NP_001135974.1	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13 like	750					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		TCTGCTCGACGTCTGAAACAT	0.647000													30	43					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39230053	39230053	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:39230053G>A	ENST00000340369.3	-	2	1112	c.884C>T	c.(883-885)tCc>tTc	p.S295F	XIRP1_ENST00000396251.1_Missense_Mutation_p.S295F|XIRP1_ENST00000421646.1_Intron	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	295							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CTCCTCCAGGGAAATCCCCCG	0.637000													30	40					0	0	1	0	0
RIPK4	54101	broad.mit.edu	37	21	43161141	43161141	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:43161141C>T	ENST00000352483.2	-	9	2420	c.2356G>A	c.(2356-2358)Gcg>Acg	p.A786T	RIPK4_ENST00000332512.3_Missense_Mutation_p.A738T|RIPK4_ENST00000544709.1_Missense_Mutation_p.A675T|AP001615.9_ENST00000423276.1_RNA|RIPK4_ENST00000542057.1_Missense_Mutation_p.A675T			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	738						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						AGGTGCAGCGCGCTGAGCCCC	0.687000													101	14					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55942356	55942356	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:55942356G>A	ENST00000244728.5	-	18	2225	c.1828C>T	c.(1828-1830)Cct>Tct	p.P610S	COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Missense_Mutation_p.P10S|COL21A1_ENST00000535941.1_Missense_Mutation_p.P610S|COL21A1_ENST00000370819.1_Missense_Mutation_p.P607S	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	610	Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CGGTTTCCAGGAAATCCTGGG	0.313000													6	6					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47367742	47367742	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:47367742C>T	ENST00000285039.7	-	35	4993	c.4694G>A	c.(4693-4695)gGg>gAg	p.G1565E	MYO5B_ENST00000324581.6_Missense_Mutation_p.G680E|MYO5B_ENST00000592688.1_Missense_Mutation_p.G135E|SCARNA17_ENST00000589499.1_RNA	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1565	Dilute.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CACCTCATCCCCGCTGTACTG	0.507000													93	130					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13029765	13029765	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:13029765G>A	ENST00000399002.2	+	2	564	c.290G>A	c.(289-291)aGa>aAa	p.R97K	SPTLC3_ENST00000378194.4_Missense_Mutation_p.R97K|SPTLC3_ENST00000476791.1_3'UTR	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	97					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	GCTGTGGAAAGAAAAGAACAA	0.428000													60	54					0	0	1	0	0
CTNNA1	1495	broad.mit.edu	37	5	138163296	138163296	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:138163296C>T	ENST00000302763.7	+	7	1041	c.951C>T	c.(949-951)gcC>gcT	p.A317A	CTNNA1_ENST00000518825.1_Silent_p.A317A|CTNNA1_ENST00000355078.5_Silent_p.A214A	NM_001903.2	NP_001894.2	P35221	CTNA1_HUMAN	catenin (cadherin-associated protein), alpha 1, 102kDa	317					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			NS(1)|breast(7)|cervix(2)|endometrium(4)|kidney(6)|large_intestine(16)|lung(9)|oesophagus(2)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	52			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTGGGGCTGCCTTGATGGCCG	0.577000													21	55					0	0	1	0	0
NMT1	4836	broad.mit.edu	37	17	43138778	43138778	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:43138778T>C	ENST00000592782.1	+	2	212	c.81T>C	c.(79-81)caT>caC	p.H27H	NMT1_ENST00000258960.2_Silent_p.H27H|NMT1_ENST00000590114.1_3'UTR			P30419	NMT1_HUMAN	N-myristoyltransferase 1	27					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)	8		Prostate(33;0.155)				GGAACGGCCATGAGCACTGCA	0.607000													15	25					0	0	1	0	0
DENND1C	79958	broad.mit.edu	37	19	6481703	6481703	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:6481703C>T	ENST00000381480.2	-	1	116	c.4G>A	c.(4-6)Gaa>Aaa	p.E2K	DENND1C_ENST00000543576.1_5'UTR|DENND1C_ENST00000591030.1_5'UTR	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	2						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						GCTCTGGATTCCATGGTCCCT	0.677000													15	24					0	0	1	0	0
AGAP2	116986	broad.mit.edu	37	12	58127820	58127820	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:58127820A>G	ENST00000257897.3	-	5	615	c.530T>C	c.(529-531)gTg>gCg	p.V177A	AGAP2_ENST00000547588.1_Missense_Mutation_p.V513A	NM_014770.3	NP_055585.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	513					axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						TTGTGTCCCCACCAGTGCCAA	0.582000													9	29					0	0	1	0	0
XRCC2	7516	broad.mit.edu	37	7	152346416	152346416	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:152346416T>C	ENST00000359321.1	-	3	239	c.154A>G	c.(154-156)Aca>Gca	p.T52A	XRCC2_ENST00000495707.1_5'UTR	NM_005431.1	NP_005422.1	O43543	XRCC2_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 2	52					meiosis	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity			NS(1)|breast(1)|large_intestine(5)|liver(1)|lung(1)|prostate(2)	11		all_hematologic(28;0.0592)|Prostate(32;0.081)	OV - Ovarian serous cystadenocarcinoma(82;0.0423)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0429)		GTTTTTCCTGTTCCTTCTGGG	0.363000								Homologous recombination					34	38					0	0	1	0	0
C16orf92	146378	broad.mit.edu	37	16	30035385	30035385	+	Missense_Mutation	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:30035385C>A	ENST00000300575.2	+	3	376	c.355C>A	c.(355-357)Ctt>Att	p.L119I		NM_001109659.1|NM_001109660.1	NP_001103129.1|NP_001103130.1	Q96LL3	CP092_HUMAN	chromosome 16 open reading frame 92	119						integral to membrane				breast(3)|lung(3)	6						CTTCTTTCTCCTTTTCCAGTT	0.587000													51	87					7.34454e-26	7.43551e-26	1	1	0
NAF1	92345	broad.mit.edu	37	4	164050306	164050306	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:164050306G>A	ENST00000274054.2	-	8	1421	c.1228C>T	c.(1228-1230)Cct>Tct	p.P410S	NAF1_ENST00000422287.2_Intron|NAF1_ENST00000509434.1_Intron	NM_138386.2	NP_612395.2	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 ribonucleoprotein	410					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(10)|ovary(2)	21	all_hematologic(180;0.166)	Prostate(90;0.109)				CTCTGAGAAGGAAATCCTGAA	0.483000													37	29					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9520184	9520184	+	Silent	SNP	G	G	A	rs141553527		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:9520184G>A	ENST00000378429.3	-	11	2631	c.2085C>T	c.(2083-2085)ctC>ctT	p.L695L	PAK7_ENST00000378423.1_Silent_p.L695L|PAK7_ENST00000353224.5_Silent_p.L695L	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	695	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			ATGGATGTCCGAGGAGTTCCT	0.512000													122	146					0	0	1	0	0
GRAMD3	65983	broad.mit.edu	37	5	125816343	125816343	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:125816343A>G	ENST00000285689.3	+	8	1140	c.679A>G	c.(679-681)Aat>Gat	p.N227D	GRAMD3_ENST00000515200.1_Missense_Mutation_p.N204D|GRAMD3_ENST00000513040.1_Missense_Mutation_p.N242D|RP11-517I3.1_ENST00000515808.1_RNA|GRAMD3_ENST00000502348.1_Missense_Mutation_p.N118D|GRAMD3_ENST00000511134.1_Missense_Mutation_p.N211D|GRAMD3_ENST00000543198.1_Missense_Mutation_p.N204D|GRAMD3_ENST00000544396.1_Missense_Mutation_p.N123D|RP11-517I3.1_ENST00000512500.1_RNA|GRAMD3_ENST00000542322.1_Missense_Mutation_p.N235D	NM_023927.2	NP_076416.2	Q96HH9	GRAM3_HUMAN	GRAM domain containing 3	227										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0401)|OV - Ovarian serous cystadenocarcinoma(64;0.0604)|all cancers(49;0.108)		TAACAGTCCCAATCCATCTTC	0.388000													24	42					0	0	1	0	0
PHTF1	10745	broad.mit.edu	37	1	114255996	114255996	+	Missense_Mutation	SNP	G	G	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:114255996G>C	ENST00000369604.1	-	8	1171	c.688C>G	c.(688-690)Cat>Gat	p.H230D	PHTF1_ENST00000393357.2_Missense_Mutation_p.H230D|PHTF1_ENST00000357783.2_Missense_Mutation_p.H230D|PHTF1_ENST00000474926.1_5'UTR|PHTF1_ENST00000447664.2_Intron|PHTF1_ENST00000369598.1_Missense_Mutation_p.H185D|PHTF1_ENST00000369600.1_Missense_Mutation_p.H177D|PHTF1_ENST00000369596.2_Missense_Mutation_p.H177D			Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	230						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATGATAGGATGGACACAACTT	0.333000													37	49					0	0	1	0	0
TRIM13	10206	broad.mit.edu	37	13	50586079	50586079	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:50586079G>A	ENST00000356017.4	+	4	400	c.12G>A	c.(10-12)atG>atA	p.M4I	TRIM13_ENST00000378182.3_Start_Codon_SNP_p.M1I|TRIM13_ENST00000457662.2_Start_Codon_SNP_p.M1I|TRIM13_ENST00000478111.1_Intron|TRIM13_ENST00000298772.5_Missense_Mutation_p.M4I|TRIM13_ENST00000420995.2_Start_Codon_SNP_p.M1I			O60858	TRI13_HUMAN	tripartite motif containing 13	1					anatomical structure morphogenesis|ER-associated protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination	cytoplasm|endoplasmic reticulum membrane|integral to membrane	protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(5)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	10		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.53e-10)|COAD - Colon adenocarcinoma(199;0.205)		AGGATGTGATGGAGCTGCTTG	0.378000													54	126					0	0	1	0	0
INTS4P1	285905	broad.mit.edu	37	7	64601707	64601707	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:64601707C>T	ENST00000587624.1	+	0	105																											ATCGGCATCTCCATTGGCAGC	0.697000													7	7					0	0	1	0	0
PRMT5	10419	broad.mit.edu	37	14	23393690	23393690	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:23393690G>A	ENST00000324366.8	-	10	1297	c.1074C>T	c.(1072-1074)gtC>gtT	p.V358V	PRMT5-AS1_ENST00000599580.1_RNA|PRMT5-AS1_ENST00000595662.1_RNA|PRMT5-AS1_ENST00000590290.1_RNA|PRMT5-AS1_ENST00000587245.2_RNA|PRMT5_ENST00000397440.4_Silent_p.V187V|PRMT5_ENST00000216350.8_Silent_p.V297V|PRMT5_ENST00000397441.2_Silent_p.V341V|PRMT5_ENST00000538452.1_Silent_p.V252V|PRMT5_ENST00000553897.1_Silent_p.V314V	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	358					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		GCACTCACTGGACATTGGTAT	0.468000													23	58					0	0	1	0	0
SYT5	6861	broad.mit.edu	37	19	55689594	55689594	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:55689594C>T	ENST00000354308.3	-	3	591	c.222G>A	c.(220-222)gtG>gtA	p.V74V	SYT5_ENST00000590851.1_Intron|SYT5_ENST00000537500.1_Silent_p.V74V	NM_003180.2	NP_003171.2	O00445	SYT5_HUMAN	synaptotagmin V	74					energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity			kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CCAGCCCCTTCACTTCCTGAA	0.622000													6	14					0	0	1	0	0
GAPVD1	26130	broad.mit.edu	37	9	128111772	128111772	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:128111772C>T	ENST00000470056.1	+	18	3352	c.3192C>T	c.(3190-3192)caC>caT	p.H1064H	GAPVD1_ENST00000312123.9_Silent_p.H1070H|GAPVD1_ENST00000394104.2_Silent_p.H1109H|GAPVD1_ENST00000394105.2_Silent_p.H1118H|GAPVD1_ENST00000495955.1_Silent_p.H1109H|GAPVD1_ENST00000297933.6_Silent_p.H1091H|GAPVD1_ENST00000394083.2_Silent_p.H1043H|GAPVD1_ENST00000265956.4_Silent_p.H1083H			Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	1109					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						AAGCAGCCCACCCGCAGGATT	0.483000													40	5					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40421497	40421497	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:40421497G>A	ENST00000221347.6	-	5	2431	c.2424C>T	c.(2422-2424)ctC>ctT	p.L808L		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	808	Cys-rich.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGCCCGGAGCGAGCTGGAGAC	0.706000													8	9					0	0	1	0	0
LMOD3	56203	broad.mit.edu	37	3	69171427	69171427	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:69171427C>T	ENST00000420581.2	-	1	290	c.111G>A	c.(109-111)tcG>tcA	p.S37S	LMOD3_ENST00000475434.1_Silent_p.S37S|LMOD3_ENST00000489031.1_Silent_p.S37S	NM_198271.3	NP_938012.2	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	37						cytoplasm|cytoskeleton	tropomyosin binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)	13		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		CTTCCATTTCCGACTGCAGTT	0.443000													9	15					0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4968024	4968024	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:4968024C>T	ENST00000380373.2	-	1	332	c.307G>A	c.(307-309)Gaa>Aaa	p.E103K	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	103					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGAAGAATTCCTGGGCAAAG	0.443000													64	152					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141754666	141754666	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:141754666C>T	ENST00000475668.2	+	27	3326	c.3272C>T	c.(3271-3273)cCa>cTa	p.P1091L	MGAM_ENST00000549489.2_Missense_Mutation_p.P1091L			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1091	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AAGAAGAATCCATTTGGGATT	0.488000													53	56					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76456121	76456121	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:76456121G>A	ENST00000396423.2	+	2	288	c.164G>A	c.(163-165)aGa>aAa	p.R55K	HNF4G_ENST00000354370.1_Missense_Mutation_p.R18K	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	18					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TGTGGGGACAGAGCAACAGGA	0.453000													48	65					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61601727	61601727	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:61601727G>A	ENST00000583023.1	+	2	315	c.304G>A	c.(304-306)Gat>Aat	p.D102N	KCNH6_ENST00000580652.1_Missense_Mutation_p.D102N|KCNH6_ENST00000456941.2_Missense_Mutation_p.D102N|KCNH6_ENST00000314672.5_Missense_Mutation_p.D102N|KCNH6_ENST00000581784.1_Missense_Mutation_p.D102N	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	102	PAC.				regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	CTACCGCAAGGATGGTGAGGC	0.647000													33	34					0	0	1	0	0
LIN28A	79727	broad.mit.edu	37	1	26737876	26737876	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:26737876G>A	ENST00000326279.6	+	2	145		c.e2-1		LIN28A_ENST00000254231.4_Splice_Site	NM_024674.4	NP_078950.1	Q9H9Z2	LN28A_HUMAN	lin-28 homolog A (C. elegans)						miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)	8						CCTCTCTCCAGGTGGCTGCGC	0.736000													6	11					0	0	1	0	0
PRAMEF6	440561	broad.mit.edu	37	1	13001267	13001267	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:13001267G>A	ENST00000376189.1	-	3	515	c.416C>T	c.(415-417)cCa>cTa	p.P139L	PRAMEF6_ENST00000376192.5_Intron|PRAMEF6_ENST00000415464.2_Missense_Mutation_p.P139L	NM_001010889.2	NP_001010889.1	Q5VXH4	PRAM6_HUMAN	PRAME family member 6	139								p.P139Q(1)		NS(1)|kidney(1)|lung(5)|urinary_tract(2)	9	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCTCATCCTTGGACAGTCCTG	0.512000													39	759					0	0	1	0	0
PDLIM3	27295	broad.mit.edu	37	4	186456496	186456496	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:186456496C>T	ENST00000284767.5	-	1	160	c.93_splice	c.e1+1	p.R31_splice	PDLIM3_ENST00000284771.6_Splice_Site_p.R31_splice|PDLIM3_ENST00000284770.5_Splice_Site_p.R31_splice			Q53GG5	PDLI3_HUMAN	PDZ and LIM domain 3	31	PDZ.					sarcomere	zinc ion binding			breast(2)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		CGACACCTACCCTGGTGATGA	0.682000													9	12					0	0	1	0	0
CHRDL2	25884	broad.mit.edu	37	11	74414401	74414401	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:74414401G>A	ENST00000376332.3	-	8	1391	c.895C>T	c.(895-897)Ccc>Tcc	p.P299S	CHRDL2_ENST00000263671.5_Missense_Mutation_p.P299S|CHRDL2_ENST00000534159.1_5'UTR	NM_001278473.1	NP_001265402.1	Q6WN34	CRDL2_HUMAN	chordin-like 2	299	VWFC 3.				cartilage development|cell differentiation|ossification	extracellular region|mitochondrion				endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)|skin(2)	15	Hepatocellular(1;0.098)					TGACGGCAGGGGTACTCGGTG	0.657000													26	34					0	0	1	0	0
SRI	6717	broad.mit.edu	37	7	87838680	87838680	+	Missense_Mutation	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:87838680C>A	ENST00000265729.2	-	6	537	c.485G>T	c.(484-486)tGc>tTc	p.C162F	SRI_ENST00000431660.1_Missense_Mutation_p.C147F|SRI_ENST00000490437.1_Missense_Mutation_p.C119F|SRI_ENST00000419179.1_Missense_Mutation_p.C122F|SRI_ENST00000394641.3_Missense_Mutation_p.C147F	NM_003130.3	NP_003121.1	P30626	SORCN_HUMAN	sorcin	162	EF-hand 4.				heart development|intracellular sequestering of iron ion|muscle organ development|regulation of action potential|regulation of heart contraction|regulation of striated muscle contraction|signal transduction	sarcoplasmic reticulum membrane	calcium channel regulator activity|calcium ion binding|receptor binding			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	5	Esophageal squamous(14;0.00202)					TTTGACGCAGCAGGCGATGTA	0.443000													33	51					4.34311e-12	4.36842e-12	1	1	0
NYNRIN	57523	broad.mit.edu	37	14	24886501	24886501	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:24886501C>T	ENST00000382554.3	+	9	5864	c.5546C>T	c.(5545-5547)cCc>cTc	p.P1849L		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1849					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TGGGTGGGTCCCTTCTATATC	0.572000													11	11					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052817	15052817	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:15052817G>A	ENST00000248072.3	+	1	517	c.517G>A	c.(517-519)Gaa>Aaa	p.E173K		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					CACAAATATGGAAATTCCGCA	0.473000													79	115					0	0	1	0	0
LOC728323	728323	broad.mit.edu	37	2	243064452	243064452	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:243064452C>T	ENST00000456398.1	+	0	571																											AGGACAAATTCGAGCATCTTA	0.378000													20	16					0	0	1	0	0
SLC1A7	6512	broad.mit.edu	37	1	53608038	53608038	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:53608038G>A	ENST00000371494.4	-	1	211	c.84C>T	c.(82-84)atC>atT	p.I28I	SLC1A7_ENST00000371491.4_Silent_p.I28I	NM_006671.4	NP_006662.3	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter), member 7	28						integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	GGCAGCCCACGATGACAGACA	0.652000													9	6					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64375003	64375003	+	Missense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:64375003A>T	ENST00000265459.6	-	23	5265	c.4804T>A	c.(4804-4806)Tca>Aca	p.S1602T	NRXN2_ENST00000377551.1_Missense_Mutation_p.S1602T|NRXN2_ENST00000301894.2_Missense_Mutation_p.S556T|NRXN2_ENST00000409571.1_Missense_Mutation_p.S1595T|NRXN2_ENST00000377559.3_Missense_Mutation_p.S1532T	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1602					cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CCGGGGGCTGAGGTCACGCCG	0.751000													3	16					0	0	1	0	0
TULP1	7287	broad.mit.edu	37	6	35479494	35479494	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:35479494C>T	ENST00000229771.6	-	4	359	c.280G>A	c.(280-282)Gac>Aac	p.D94N	TULP1_ENST00000322263.4_Intron	NM_003322.3	NP_003313.3	O00294	TULP1_HUMAN	tubby like protein 1	94					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						GCCTCGGGGTCCCTGAGGAAC	0.731000													4	5					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106899245	106899245	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:106899245G>A	ENST00000369701.3	+	8	1529		c.e8+1			NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3							integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GTTGCCAAAGGTACTGCATGC	0.507000													48	3					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12656048	12656048	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:12656048C>T	ENST00000425538.1	+	10	1643	c.1443C>T	c.(1441-1443)tcC>tcT	p.S481S	MYOCD_ENST00000395988.1_Silent_p.S385S|MYOCD_ENST00000343344.4_Silent_p.S481S	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	481	Ser-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CCTCCCCCTCCTTCGGCCTGC	0.632000													46	55					0	0	1	0	0
GTF2E2	2961	broad.mit.edu	37	8	30469831	30469831	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:30469831G>A	ENST00000355904.4	-	5	816	c.534C>T	c.(532-534)tcC>tcT	p.S178S	GTF2E2_ENST00000522833.1_5'UTR	NM_002095.4	NP_002086.1	P29084	T2EB_HUMAN	general transcription factor IIE, polypeptide 2, beta 34kDa	178					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIE complex	DNA binding|protein binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(542;0.113)|Kidney(114;0.135)		CAGCTTTCTGGGAATTGGGCA	0.348000													25	9					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62393590	62393590	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:62393590C>T	ENST00000346178.4	-	24	2753	c.2738G>A	c.(2737-2739)cGg>cAg	p.R913Q	GANAB_ENST00000356638.3_Missense_Mutation_p.R891Q|GANAB_ENST00000540933.1_Missense_Mutation_p.R794Q|GANAB_ENST00000534779.1_Missense_Mutation_p.R799Q	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	891					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						TATCACCACCCGCTCAATCCA	0.527000													163	214					0	0	1	0	0
TCEAL5	340543	broad.mit.edu	37	X	102529337	102529337	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:102529337C>T	ENST00000372680.1	-	3	449	c.155G>A	c.(154-156)gGa>gAa	p.G52E		NM_001012979.2	NP_001012997.1	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	52	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	11						ctctcgctttccctcgcattc	0.522000													68	8					0	0	1	0	0
PRKD3	23683	broad.mit.edu	37	2	37543423	37543423	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:37543423A>G	ENST00000379066.1	-	2	1007	c.245T>C	c.(244-246)tTa>tCa	p.L82S	PRKD3_ENST00000234179.2_Missense_Mutation_p.L82S			O94806	KPCD3_HUMAN	protein kinase D3	82					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				GACAGCAGATAAAGACAGTTC	0.398000													76	74					0	0	1	0	0
MKX	283078	broad.mit.edu	37	10	28030399	28030399	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:28030399G>A	ENST00000375790.5	-	3	655	c.223C>T	c.(223-225)Cgg>Tgg	p.R75W	MKX_ENST00000419761.1_Missense_Mutation_p.R75W			Q8IYA7	MKX_HUMAN	mohawk homeobox	75					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16						AGGGCCTGCCGCTTGTGCCTC	0.662000													40	10					0	0	1	0	0
SLC12A4	6560	broad.mit.edu	37	16	67991661	67991661	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:67991661G>A	ENST00000422611.2	-	4	573	c.534C>T	c.(532-534)acC>acT	p.T178T	SLC12A4_ENST00000576616.1_Silent_p.T176T|SLC12A4_ENST00000572010.1_5'UTR|SLC12A4_ENST00000537830.2_Silent_p.T170T|SLC12A4_ENST00000316341.3_Silent_p.T176T|SLC12A4_ENST00000572037.1_Silent_p.T128T|SLC12A4_ENST00000338335.3_Silent_p.T176T|SLC12A4_ENST00000541864.2_Silent_p.T145T	NM_001145962.1	NP_001139434.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4	176					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|prostate(4)|skin(2)|urinary_tract(3)	29		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCACACCGTTGGTGGCGATGG	0.637000													19	26					0	0	1	0	0
DDX3X	1654	broad.mit.edu	37	X	41198333	41198333	+	Nonsense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:41198333A>T	ENST00000399959.2	+	3	1003	c.148A>T	c.(148-150)Aaa>Taa	p.K50*	DDX3X_ENST00000478993.1_3'UTR|DDX3X_ENST00000457138.2_Intron|DDX3X_ENST00000441189.2_Nonsense_Mutation_p.K50*|DDX3X_ENST00000542215.1_Nonsense_Mutation_p.K94*	NM_001193416.1|NM_001193417.1|NM_001356.3	NP_001180345.1|NP_001180346.1|NP_001347.3	O00571	DDX3X_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	50				K -> R (in Ref. 3; AAC51830/AAC51829).	interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			NS(3)|breast(8)|central_nervous_system(36)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84						AGAAGCTACTAAAGGTAGGTC	0.353000										HNSCC(61;0.18)			36	1					0	0	1	0	0
FAF1	11124	broad.mit.edu	37	1	51061849	51061849	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:51061849G>A	ENST00000396153.2	-	9	1235	c.784C>T	c.(784-786)Cga>Tga	p.R262*	FAF1_ENST00000371778.4_Nonsense_Mutation_p.R262*|FAF1_ENST00000472808.1_5'UTR|FAF1_ENST00000545823.1_Nonsense_Mutation_p.R20*	NM_007051.2	NP_008982.1	Q9UNN5	FAF1_HUMAN	Fas (TNFRSF6) associated factor 1	262					apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity	p.0?(1)		breast(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|pancreas(2)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		ACTGTAAGTCGATGGCAGGGA	0.453000													34	19					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242144280	242144280	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:242144280G>A	ENST00000274979.8	+	10	1155	c.1051_splice	c.e10-1	p.G351_splice	ANO7_ENST00000402430.3_Splice_Site_p.G350_splice	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	351						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						CTCTCTACAGGGTTTTACACA	0.617000													29	25					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	3990781	3990781	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:3990781G>A	ENST00000381638.2	-	14	2413	c.2289C>T	c.(2287-2289)ttC>ttT	p.F763F	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	763							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						CAAGACCCGCGAAGTCCAGAA	0.303000													40	48					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167420055	167420055	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:167420055C>T	ENST00000519204.1	+	4	809	c.691C>T	c.(691-693)Ctg>Ttg	p.L231L	TENM2_ENST00000545108.1_Silent_p.L352L|TENM2_ENST00000518659.1_Silent_p.L352L|TENM2_ENST00000403607.2_Silent_p.L185L|TENM2_ENST00000520394.1_Silent_p.L161L					teneurin transmembrane protein 2																		GCCCCGCCTGCTGCCCAGGAA	0.597000													27	70					0	0	1	0	0
NR5A2	2494	broad.mit.edu	37	1	200017327	200017327	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:200017327G>A	ENST00000367362.3	+	5	737	c.491G>A	c.(490-492)gGa>gAa	p.G164E	NR5A2_ENST00000236914.3_Missense_Mutation_p.G118E|NR5A2_ENST00000544748.1_Missense_Mutation_p.G92E	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	164					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					ATGCGTGGAGGAAGGAATAAG	0.483000													47	68					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075646	9075646	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:9075646G>A	ENST00000397910.4	-	3	12003	c.11800C>T	c.(11800-11802)Cct>Tct	p.P3934S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3935	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GACTCAGAAGGGGCAATTCTC	0.483000													14	29					0	0	1	0	0
SNORD115-42	100033816	broad.mit.edu	37	15	25492538	25492538	+	RNA	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:25492538T>C	ENST00000364273.1	+	0	47					NR_003357.1																						AGGTGATGACTTAAAAATCAT	0.498000													151	41					0	0	1	0	0
NKAIN2	154215	broad.mit.edu	37	6	124125348	124125348	+	Translation_Start_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:124125348G>A	ENST00000368417.1	+	1	63	c.3G>A	c.(1-3)atG>atA	p.M1I	NKAIN2_ENST00000476571.1_3'UTR|NKAIN2_ENST00000368416.1_Start_Codon_SNP_p.M1I|NKAIN2_ENST00000546092.1_Start_Codon_SNP_p.M1I	NM_001040214.1	NP_001035304.1	Q5VXU1	NKAI2_HUMAN	Na+/K+ transporting ATPase interacting 2	1						integral to membrane|plasma membrane				cervix(1)|endometrium(1)|large_intestine(3)|lung(12)|skin(2)	19				GBM - Glioblastoma multiforme(226;0.104)		CGGAAACCATGGGTTATTGCA	0.532000													22	68					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108011990	108011990	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:108011990T>A	ENST00000280758.5	+	10	2815	c.2287T>A	c.(2287-2289)Tcc>Acc	p.S763T	BTBD11_ENST00000420571.2_Intron|BTBD11_ENST00000490090.2_Missense_Mutation_p.S763T|BTBD11_ENST00000357167.4_Missense_Mutation_p.S300T	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	763						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						TGATATCCTGTCCCTGGAGGA	0.587000													33	23					0	0	1	0	0
SEC14L5	9717	broad.mit.edu	37	16	5064878	5064878	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:5064878G>A	ENST00000251170.7	+	16	2178	c.1998G>A	c.(1996-1998)ctG>ctA	p.L666L	RP11-165E7.1_ENST00000588778.1_RNA	NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	666	Ser-rich.					integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						TGTCCAGCCTGGAATCCTGCA	0.637000													30	37					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82579147	82579147	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:82579147G>A	ENST00000423517.2	-	6	11094	c.10757C>T	c.(10756-10758)cCa>cTa	p.P3586L	PCLO_ENST00000437081.1_Missense_Mutation_p.P306L|PCLO_ENST00000333891.8_Missense_Mutation_p.P3586L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3517					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GTCTTTGGGTGGAGATGTGGC	0.473000													22	48					0	0	1	0	0
AKAP14	158798	broad.mit.edu	37	X	119037261	119037261	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:119037261G>A	ENST00000371431.3	+	3	349	c.75G>A	c.(73-75)ccG>ccA	p.P25P	AKAP14_ENST00000334356.2_Silent_p.P25P|AKAP14_ENST00000371422.1_Silent_p.P25P|AKAP14_ENST00000371423.2_Silent_p.P25P|AKAP14_ENST00000394594.2_Silent_p.P25P|AKAP14_ENST00000371425.4_Silent_p.P25P	NM_178813.5	NP_848928.1	Q86UN6	AKA28_HUMAN	A kinase (PRKA) anchor protein 14	25						cytoplasm		p.P25P(1)		endometrium(4)|large_intestine(1)|lung(8)	13						AAACAATGCCGAATACACAAG	0.403000													3	44					0	0	1	0	0
CPXM1	56265	broad.mit.edu	37	20	2777928	2777928	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:2777928C>T	ENST00000380605.2	-	6	806	c.742G>A	c.(742-744)Gtg>Atg	p.V248M		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	248	F5/8 type C.				cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						AAGCGGGCCACCTGGGGCTCC	0.642000													4	6					0	0	1	0	0
ITGA3	3675	broad.mit.edu	37	17	48153768	48153768	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:48153768C>T	ENST00000320031.8	+	13	2083	c.1753C>T	c.(1753-1755)Cgg>Tgg	p.R585W	ITGA3_ENST00000544892.1_3'UTR|ITGA3_ENST00000007722.7_Missense_Mutation_p.R585W	NM_002204.2|NM_005501.2	NP_002195.1|NP_005492.1	P26006	ITA3_HUMAN	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	585					blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	31						CGATCGCCCCCGGCTGGGGCT	0.622000													119	177					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	21592356	21592356	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:21592356C>T	ENST00000298925.5	+	19	2264	c.2111C>T	c.(2110-2112)cCa>cTa	p.P704L	NELL1_ENST00000325319.5_Missense_Mutation_p.P619L|NELL1_ENST00000532434.1_Missense_Mutation_p.P629L|NELL1_ENST00000529218.1_3'UTR|NELL1_ENST00000357134.5_Missense_Mutation_p.P676L			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	676	VWFC 4.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						TGCCAGAATCCAAGTGCTGAC	0.438000													63	71					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94344033	94344033	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:94344033G>A	ENST00000282020.4	+	10	1717	c.1459G>A	c.(1459-1461)Gaa>Aaa	p.E487K	GRID2_ENST00000510992.1_Missense_Mutation_p.E392K	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	487					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity	p.E487Q(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TTTTAACTACGAAATTTACGT	0.418000													31	39					0	0	1	0	0
ELAVL3	1995	broad.mit.edu	37	19	11569355	11569355	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:11569355G>A	ENST00000359227.3	-	4	829	c.405C>T	c.(403-405)acC>acT	p.T135T	ELAVL3_ENST00000438662.2_Silent_p.T135T	NM_001420.3|NM_032281.2	NP_001411.2|NP_115657.2	Q14576	ELAV3_HUMAN	ELAV like neuron-specific RNA binding protein 3	135	RRM 2.				cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15						TCTGGCTCATGGTCTTGGGGA	0.607000													58	100					0	0	1	0	0
PABPN1L	390748	broad.mit.edu	37	16	88931527	88931527	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:88931527C>T	ENST00000419291.2	-	4	480	c.469G>A	c.(469-471)Ggg>Agg	p.G157R	PABPN1L_ENST00000411789.2_Missense_Mutation_p.G157R|PABPN1L_ENST00000427766.1_Intron|PABPN1L_ENST00000378358.4_Missense_Mutation_p.G157R	NM_001080487.2	NP_001073956.2	A6NDY0	EPAB2_HUMAN	poly(A) binding protein, nuclear 1-like (cytoplasmic)	157	RRM.					cytoplasm	nucleotide binding|RNA binding			kidney(1)	1						GCGGAGCCCCCGTAGTCCACC	0.637000													5	10					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3426136	3426136	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:3426136C>T	ENST00000529482.1	+	0	845																											AGAAGCATTTCCAGCACATCC	0.607000													40	50					0	0	1	0	0
CLVS2	134829	broad.mit.edu	37	6	123369775	123369775	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:123369775C>T	ENST00000275162.4	+	4	1908	c.573C>T	c.(571-573)ttC>ttT	p.F191F	CLVS2_ENST00000368438.1_Silent_p.F45F	NM_001010852.2	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2	191	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						AGGATAGTTTCCCAGCGCGAT	0.373000													48	53					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116631994	116631994	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:116631994G>A	ENST00000395715.3	-	3	908	c.331C>T	c.(331-333)Ccc>Tcc	p.P111S	TRPS1_ENST00000519674.1_Missense_Mutation_p.P98S|TRPS1_ENST00000520276.1_Missense_Mutation_p.P102S|TRPS1_ENST00000220888.5_Missense_Mutation_p.P98S|TRPS1_ENST00000519076.1_Intron	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	98					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GGAAAGGAGGGAAAGTTTCCT	0.488000									Langer-Giedion syndrome				53	81					0	0	1	0	0
CPEB1	64506	broad.mit.edu	37	15	83226581	83226581	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:83226581G>A	ENST00000563800.1	-	4	2341	c.616C>T	c.(616-618)Cga>Tga	p.R206*	CPEB1_ENST00000450751.2_Nonsense_Mutation_p.R104*|CPEB1_ENST00000423133.2_Nonsense_Mutation_p.R104*|RP11-379H8.1_ENST00000568285.1_Intron|CPEB1_ENST00000568757.1_Nonsense_Mutation_p.R104*|CPEB1_ENST00000568128.1_Nonsense_Mutation_p.R179*|CPEB1_ENST00000564522.1_Nonsense_Mutation_p.R104*|CPEB1_ENST00000562019.1_Nonsense_Mutation_p.R179*|CPEB1_ENST00000398591.2_Nonsense_Mutation_p.R104*|CPEB1_ENST00000398592.2_Intron|CPEB1_ENST00000261723.6_Nonsense_Mutation_p.R182*			Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding protein 1	179	Ser-rich.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(1)|skin(1)	28			BRCA - Breast invasive adenocarcinoma(143;0.229)			CTGCTAGATCGAGAGTCCAGG	0.532000													35	56					0	0	1	0	0
KCNH8	131096	broad.mit.edu	37	3	19384153	19384153	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:19384153C>T	ENST00000328405.2	+	4	783	c.517C>T	c.(517-519)Cac>Tac	p.H173Y		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	173						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						AGTCCTTTATCACATCTCTGG	0.448000													29	48					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141113930	141113930	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:141113930C>T	ENST00000389484.3	-	75	12482	c.11511G>A	c.(11509-11511)atG>atA	p.M3837I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3837	EGF-like 8.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTCTGTTTTTCATGTTTCTCT	0.353000										TSP Lung(27;0.18)			34	43					0	0	1	0	0
CTSW	1521	broad.mit.edu	37	11	65650791	65650791	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:65650791G>A	ENST00000528419.1	+	9	920	c.916G>A	c.(916-918)Ggg>Agg	p.G306R	CTSW_ENST00000307886.3_Missense_Mutation_p.G306R			P56202	CATW_HUMAN	cathepsin W	306					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(5)	9				READ - Rectum adenocarcinoma(159;0.168)		GTCAGAGGAGGGGATATGGGC	0.602000													69	116					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21178791	21178791	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:21178791C>T	ENST00000377122.4	-	3	637	c.241G>A	c.(241-243)Ggt>Agt	p.G81S	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377119.1_Missense_Mutation_p.G81S|NEBL_ENST00000377159.4_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	81					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						ATAAAAGCACCGATATTTTTT	0.318000													28	4					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88966266	88966266	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:88966266T>C	ENST00000333190.4	+	4	4579	c.3970T>C	c.(3970-3972)Tgc>Cgc	p.C1324R		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1324						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TCAAGATTTTTGCCATCATTC	0.393000										HNSCC(36;0.09)			77	77					0	0	1	0	0
MLNR	2862	broad.mit.edu	37	13	49795297	49795297	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:49795297G>A	ENST00000398307.1	+	1	824	c.824G>A	c.(823-825)tGg>tAg	p.W275*	MLNR_ENST00000218721.1_Nonsense_Mutation_p.W275*			O43193	MTLR_HUMAN	motilin receptor	275					digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity			endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)	14		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		CGGGAGCTGTGGAGCAGCCGG	0.711000													7	55					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29231565	29231565	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:29231565G>A	ENST00000441381.1	+	0	79																											GTGAAAAGTTGAAAAGCACAG	0.428000													58	148					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255991	140255991	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:140255991G>A	ENST00000398631.2	+	1	934	c.934G>A	c.(934-936)Gag>Aag	p.E312K	PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATTTTGAAGAGAATAATGC	0.393000													22	92					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101892298	101892298	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:101892298G>A	ENST00000360264.3	+	24	4547	c.4527G>A	c.(4525-4527)gaG>gaA	p.E1509E	CUX1_ENST00000437600.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000556210.1_Silent_p.E1340E|CUX1_ENST00000546411.2_Silent_p.E1396E|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000292535.7_Silent_p.E1498E|CUX1_ENST00000549414.2_Silent_p.E1476E|CUX1_ENST00000550008.2_Silent_p.E1442E|CUX1_ENST00000560541.1_Intron	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	1498					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						CCAGCCGGGAGGAACCTATCG	0.726000													3	9					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8374650	8374650	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:8374650C>T	ENST00000538603.1	-	7	1721	c.1163G>A	c.(1162-1164)gGg>gAg	p.G388E	FAM90A1_ENST00000307435.6_Missense_Mutation_p.G388E	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	388							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		AGGCTGGGCCCCATCATGGCT	0.647000													8	38					0	0	1	0	0
OR4K15	81127	broad.mit.edu	37	14	20443712	20443712	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:20443712C>T	ENST00000305051.5	+	1	110	c.35C>T	c.(34-36)cCt>cTt	p.P12L		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTTTCTCTCCTATTCAGGTA	0.378000													19	38					0	0	1	0	0
SMG5	23381	broad.mit.edu	37	1	156222768	156222768	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:156222768G>A	ENST00000361813.5	-	18	2748	c.2604C>T	c.(2602-2604)ctC>ctT	p.L868L	SMG5_ENST00000368267.4_Intron	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	868					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					GGATGACAGGGAGATGGTGGC	0.572000													11	13					0	0	1	0	0
KDM8	79831	broad.mit.edu	37	16	27221524	27221524	+	Missense_Mutation	SNP	C	C	T	rs34614782	byFrequency	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:27221524C>T	ENST00000286096.4	+	2	253	c.80C>T	c.(79-81)cCg>cTg	p.P27L	KDM8_ENST00000380948.2_Missense_Mutation_p.P27L|KDM8_ENST00000568965.1_Missense_Mutation_p.P27L|KDM8_ENST00000441782.2_Missense_Mutation_p.P65L	NM_024773.2	NP_079049.2	Q8N371	KDM8_HUMAN	lysine (K)-specific demethylase 8	27					G2/M transition of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|histone demethylase activity (H3-K36 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen										GCGCTCCTGCCGCACAGTAAA	0.622000													41	55					0	0	1	0	0
LRP10	26020	broad.mit.edu	37	14	23346598	23346598	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:23346598C>T	ENST00000359591.4	+	7	2695	c.2004C>T	c.(2002-2004)ccC>ccT	p.P668P	LRP10_ENST00000546834.1_Intron|LRP10_ENST00000470660.1_Intron	NM_014045.3	NP_054764.2	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein 10	668	Pro-rich.				endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		GCCTGGGGCCCCCAGGACCAA	0.677000													58	46					0	0	1	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103566802	103566802	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:103566802C>T	ENST00000380069.3	+	1	322	c.246C>T	c.(244-246)tcC>tcT	p.S82S		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	82										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						GCTCCTGCTCCCTGTTCCGGT	0.667000													23	18					0	0	1	0	0
STK19	8859	broad.mit.edu	37	6	31940093	31940093	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:31940093G>A	ENST00000375331.2	+	2	401	c.235G>A	c.(235-237)Gag>Aag	p.E79K	STK19_ENST00000375333.2_Missense_Mutation_p.E79K	NM_004197.1	NP_004188.1	P49842	STK19_HUMAN	serine/threonine kinase 19	79						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(5)|upper_aerodigestive_tract(2)	7						GACGCCCGGGGAGACCGTACG	0.602000													46	92					0	0	1	0	0
CERKL	375298	broad.mit.edu	37	2	182468676	182468676	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:182468676G>A	ENST00000410087.3	-	2	469	c.369C>T	c.(367-369)ttC>ttT	p.F123F	CERKL_ENST00000374969.2_Silent_p.F123F|CERKL_ENST00000479558.1_5'UTR|CERKL_ENST00000409440.3_Silent_p.F123F|CERKL_ENST00000374970.2_Silent_p.F123F|CERKL_ENST00000339098.5_Silent_p.F123F	NM_001030311.2|NM_201548.4	NP_001025482.1|NP_963842.1	Q49MI3	CERKL_HUMAN	ceramide kinase-like	123					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|Golgi apparatus|nucleolus	diacylglycerol kinase activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TCAAGCAGATGAAGAGTGTGA	0.328000													50	20					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29885295	29885295	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:29885295G>A	ENST00000310624.6	+	4	1699	c.1666G>A	c.(1666-1668)Gaa>Aaa	p.E556K		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	556	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						TCCAGCAAAGGAAGAGGCAAA	0.572000													154	80					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56344924	56344924	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:56344924C>T	ENST00000262290.4	+	12	2224	c.1908C>T	c.(1906-1908)ttC>ttT	p.F636F	LPO_ENST00000543544.1_Silent_p.F577F|LPO_ENST00000421678.2_Silent_p.F553F|LPO_ENST00000582328.1_Silent_p.F553F	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	636					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						GCAAGCAGTTCCAGCAGATCC	0.642000													23	21					0	0	1	0	0
TCTE1	202500	broad.mit.edu	37	6	44248076	44248076	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:44248076C>T	ENST00000371505.4	-	5	1470	c.1348G>A	c.(1348-1350)Gaa>Aaa	p.E450K	TCTE1_ENST00000371504.1_Missense_Mutation_p.E147K|TCTE1_ENST00000371503.3_Missense_Mutation_p.E147K|TMEM151B_ENST00000438774.2_Intron	NM_182539.3	NP_872345.2	Q5JU00	TCTE1_HUMAN	t-complex-associated-testis-expressed 1	450										breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AAGTCAAATTCCAGGAGGGTC	0.577000													20	77					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32912282	32912282	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:32912282A>G	ENST00000544455.1	+	11	4017	c.3790A>G	c.(3790-3792)Aaa>Gaa	p.K1264E	BRCA2_ENST00000380152.3_Missense_Mutation_p.K1264E	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1264					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		ATCTTCAAGTAAATGTCATGA	0.284000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			21	47					0	0	1	0	0
DGKH	160851	broad.mit.edu	37	13	42763238	42763238	+	Missense_Mutation	SNP	C	C	T	rs147089288		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:42763238C>T	ENST00000379274.2	+	15	1726	c.1297C>T	c.(1297-1299)Cct>Tct	p.P433S	DGKH_ENST00000498255.2_3'UTR|DGKH_ENST00000536612.1_Missense_Mutation_p.P433S|DGKH_ENST00000538674.1_Missense_Mutation_p.P324S|DGKH_ENST00000540693.1_Missense_Mutation_p.P569S|DGKH_ENST00000337343.4_Missense_Mutation_p.P569S|DGKH_ENST00000261491.4_Missense_Mutation_p.P569S			Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta	569	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		CCAGGCTGCGCCTGTTCTCCC	0.507000													19	88					0	0	1	0	0
LHB	3972	broad.mit.edu	37	19	49519937	49519937	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:49519937C>T	ENST00000221421.2	-	2	49	c.50G>A	c.(49-51)gGg>gAg	p.G17E		NM_000894.2	NP_000885.1	P01229	LSHB_HUMAN	luteinizing hormone beta polypeptide	17					cell-cell signaling|cellular nitrogen compound metabolic process|male gonad development|peptide hormone processing|progesterone biosynthetic process|signal transduction	extracellular region|soluble fraction	hormone activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	8		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)	Lutropin alfa(DB00044)|Menotropins(DB00032)	TGCCCATGCCCCGCCCATGCT	0.652000													43	78					0	0	1	0	0
PUSL1	126789	broad.mit.edu	37	1	1244489	1244489	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:1244489C>T	ENST00000379031.5	+	3	236	c.159C>T	c.(157-159)tcC>tcT	p.S53S	PUSL1_ENST00000470520.1_3'UTR	NM_153339.1	NP_699170.1	Q8N0Z8	PUSL1_HUMAN	pseudouridylate synthase-like 1	53					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			lung(3)|skin(1)|urinary_tract(1)	5	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGCTGAATTCCGTGGAGCCGG	0.766000													4	2					0	0	1	0	0
ANKH	56172	broad.mit.edu	37	5	14769258	14769258	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:14769258C>T	ENST00000284268.6	-	2	469	c.139G>A	c.(139-141)Gag>Aag	p.E47K		NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	47					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						GCCAGCATCTCGACTGCATCC	0.522000													22	5					0	0	1	0	0
EEF1A1	1915	broad.mit.edu	37	6	74229070	74229070	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:74229070C>T	ENST00000316292.9	-	2	1305	c.314G>A	c.(313-315)gGg>gAg	p.G105E	EEF1A1_ENST00000491404.1_5'UTR|EEF1A1_ENST00000309268.6_Missense_Mutation_p.G105E|EEF1A1_ENST00000331523.2_Missense_Mutation_p.G105E	NM_001402.5	NP_001393.1	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha 1	105						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity	p.G105A(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(6)|prostate(2)|skin(3)	18						CTGAGATGTCCCTGTAATCAT	0.398000											OREG0003890	type=REGULATORY REGION|Gene=LOC477388|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	46	57					0	0	1	0	0
SPATA5	166378	broad.mit.edu	37	4	123868494	123868494	+	Missense_Mutation	SNP	G	G	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:123868494G>C	ENST00000274008.3	+	9	1634	c.1565G>C	c.(1564-1566)gGa>gCa	p.G522A	SPATA5_ENST00000422835.2_3'UTR	NM_145207.2	NP_660208.2	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	522					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24						ATTGAGATTGGAGTTCCCAAT	0.512000													53	49					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37622203	37622203	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:37622203G>A	ENST00000434837.2	-	6	2007	c.829C>T	c.(829-831)Cat>Tat	p.H277Y	MDGA1_ENST00000505425.1_Missense_Mutation_p.H277Y|MDGA1_ENST00000297153.7_Missense_Mutation_p.H277Y	NM_153487.3	NP_705691.1	Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	277	Ig-like 3.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						CCAGGCCCATGGGACCACTGC	0.642000													11	36					0	0	1	0	0
MYL2	4633	broad.mit.edu	37	12	111350935	111350935	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:111350935G>A	ENST00000228841.8	-	6	414	c.367C>T	c.(367-369)Ctg>Ttg	p.L123L	MYL2_ENST00000548438.1_Silent_p.L109L	NM_000432.3	NP_000423.2	P10916	MLRV_HUMAN	myosin, light chain 2, regulatory, cardiac, slow	123	EF-hand 2.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)	12						TGCGTGGTCAGCATTTCCCGA	0.597000													70	31					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71606214	71606214	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:71606214C>T	ENST00000355962.4	-	6	714	c.581G>A	c.(580-582)tGg>tAg	p.W194*	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	194					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	GTCAATTTCCCAAGATTTCTC	0.398000													26	39					0	0	1	0	0
PDYN	5173	broad.mit.edu	37	20	1961530	1961530	+	Missense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:1961530A>T	ENST00000217305.2	-	4	429	c.204T>A	c.(202-204)ttT>ttA	p.F68L	RP4-684O24.5_ENST00000446562.1_RNA|PDYN_ENST00000540134.1_Missense_Mutation_p.F68L|PDYN_ENST00000539905.1_Missense_Mutation_p.F68L	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	68					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AGGGGGTGAAAAAAGACAGAA	0.562000													60	61					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132490833	132490833	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:132490833C>T	ENST00000333577.4	+	15	3329	c.3220C>T	c.(3220-3222)Cgg>Tgg	p.R1074W	EP400_ENST00000389561.2_Missense_Mutation_p.R1038W|EP400_ENST00000389562.2_Missense_Mutation_p.R1037W|EP400_ENST00000332482.4_Missense_Mutation_p.R1001W|EP400_ENST00000330386.6_Missense_Mutation_p.R1038W			Q96L91	EP400_HUMAN	E1A binding protein p400	1074	Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GGGCAGTGCTCGGGTCACAAC	0.552000													10	43					0	0	1	0	0
DOHH	83475	broad.mit.edu	37	19	3492320	3492320	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:3492320G>A	ENST00000427575.1	-	4	980	c.529C>T	c.(529-531)Cgc>Tgc	p.R177C	DOHH_ENST00000250937.3_Missense_Mutation_p.R177C	NM_001145165.1	NP_001138637.1	Q9BU89	DOHH_HUMAN	deoxyhypusine hydroxylase/monooxygenase	177					peptidyl-lysine modification to hypusine|post-translational protein modification	cytosol	deoxyhypusine monooxygenase activity|metal ion binding|protein binding			central_nervous_system(1)|large_intestine(1)|lung(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		AACATGGCGCGGTATCGCTCG	0.736000													10	6					0	0	1	0	0
ZC3H10	84872	broad.mit.edu	37	12	56514527	56514527	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:56514527C>T	ENST00000257940.2	+	3	457	c.181C>T	c.(181-183)Cca>Tca	p.P61S	RP11-603J24.5_ENST00000549438.1_RNA|RP11-603J24.5_ENST00000550947.1_RNA	NM_032786.1	NP_116175.1	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	61							nucleic acid binding|zinc ion binding	p.P61S(1)		breast(1)|endometrium(4)|large_intestine(1)|lung(2)|prostate(2)|skin(1)	11			OV - Ovarian serous cystadenocarcinoma(18;0.12)			ATATCGCCACCCAGACATGAG	0.557000													55	40					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245704205	245704205	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:245704205C>T	ENST00000366518.4	+	2	264	c.160C>T	c.(160-162)Ctg>Ttg	p.L54L	KIF26B_ENST00000407071.2_Silent_p.L435L			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	435					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CCCACCCTGCCTGCTGAGGGC	0.622000													36	46					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51254847	51254847	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:51254847C>T	ENST00000404971.1	-	2	1904	c.565G>A	c.(565-567)Gtc>Atc	p.V189I	NRXN1_ENST00000405581.1_Missense_Mutation_p.V189I|NRXN1_ENST00000406859.3_Missense_Mutation_p.V189I|NRXN1_ENST00000401669.2_Missense_Mutation_p.V189I|NRXN1_ENST00000406316.2_Missense_Mutation_p.V189I|NRXN1_ENST00000402717.3_Missense_Mutation_p.V189I|NRXN1_ENST00000405472.3_Missense_Mutation_p.V189I	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	189	Laminin G-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GAGGAGTTGACCCTCACGTCA	0.721000													4	3					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10130136	10130136	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:10130136C>T	ENST00000287647.3	+	35	3563	c.3470C>T	c.(3469-3471)tCc>tTc	p.S1157F	FANCD2_ENST00000419585.1_Missense_Mutation_p.S1157F|FANCD2_ENST00000383807.1_Missense_Mutation_p.S1157F|FANCD2_ENST00000383806.1_Missense_Mutation_p.S1157F|FANCD2OS_ENST00000436517.1_Intron|FANCD2OS_ENST00000524279.1_Intron	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	1157					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		CTAACAGCTTCCCTTGCCAGA	0.423000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				35	49					0	0	1	0	0
PSEN2	5664	broad.mit.edu	37	1	227081808	227081808	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:227081808C>T	ENST00000366782.1	+	12	1772	c.1272C>T	c.(1270-1272)tgC>tgT	p.C424C	PSEN2_ENST00000422240.2_Silent_p.C390C|PSEN2_ENST00000391872.2_Silent_p.C424C|PSEN2_ENST00000340188.4_Silent_p.C358C|PSEN2_ENST00000366783.3_Silent_p.C391C|PSEN2_ENST00000471728.1_3'UTR|PSEN2_ENST00000472139.2_Silent_p.C247C			P49810	PSN2_HUMAN	presenilin 2 (Alzheimer disease 4)	391					amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|urinary_tract(1)	20		Prostate(94;0.0771)				CGCTGGCCTGCTTCGTGGCCA	0.657000													25	28					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	65032667	65032667	+	Silent	SNP	T	T	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:65032667T>G	ENST00000394156.3	-	4	774	c.321A>C	c.(319-321)tcA>tcC	p.S107S	CDH11_ENST00000268603.4_Silent_p.S107S|CDH11_ENST00000566827.1_5'UTR			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	107	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GAATGTTCCCTGATTTGTCAT	0.488000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			22	38					0	0	1	0	0
C7orf63	79846	broad.mit.edu	37	7	89901167	89901167	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:89901167C>T	ENST00000389297.4	+	8	1006	c.755C>T	c.(754-756)cCc>cTc	p.P252L	C7orf63_ENST00000316089.8_Missense_Mutation_p.P252L|C7orf63_ENST00000463311.1_Intron|C7orf63_ENST00000497910.1_Missense_Mutation_p.P234L	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	252							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						GACCCAGATCCCTCTGGACAG	0.338000													11	19					0	0	1	0	0
OR10K2	391107	broad.mit.edu	37	1	158390503	158390503	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:158390503C>T	ENST00000314902.2	-	1	153	c.154G>A	c.(154-156)Gac>Aac	p.D52N		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					AGGGCCCTGTCCAGGACAATG	0.502000													57	75					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454410	84454410	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:84454410G>A	ENST00000377084.2	-	1	2118	c.1233C>T	c.(1231-1233)atC>atT	p.I411I		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	411						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CTACAGTAGCGATGTTATTGT	0.458000													29	242					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54917697	54917697	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:54917697C>T	ENST00000293373.6	+	20	2192	c.2113C>T	c.(2113-2115)Cct>Tct	p.P705S	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.P655S	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	705					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TACTATCTTCCCTTCTGAGTA	0.443000													18	47					0	0	1	0	0
GRAMD1C	54762	broad.mit.edu	37	3	113634687	113634687	+	Splice_Site	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:113634687T>C	ENST00000358160.4	+	10	1582		c.e10+2		GRAMD1C_ENST00000479212.1_Splice_Site|GRAMD1C_ENST00000472026.1_Splice_Site|GRAMD1C_ENST00000452134.2_Splice_Site|GRAMD1C_ENST00000440446.2_Splice_Site	NM_017577.4	NP_060047.3	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C							integral to membrane				NS(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	26						ATATAATAGGTTAGTCCTTGT	0.323000													27	41					0	0	1	0	0
KIR2DL4	3805	broad.mit.edu	37	19	55320288	55320288	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:55320288G>A	ENST00000396284.2	+	5	650	c.649_splice	c.e5-1	p.G217_splice	KIR2DL4_ENST00000396293.1_Intron|KIR2DL4_ENST00000346587.4_Splice_Site_p.G124_splice|KIR2DL4_ENST00000345540.5_Splice_Site_p.G219_splice|KIR2DL4_ENST00000359085.4_Splice_Site_p.G219_splice|KIR2DL4_ENST00000463062.1_Intron|KIR2DL4_ENST00000357494.4_Intron|KIR3DL1_ENST00000402254.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron					killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4											NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(2)|ovary(2)|prostate(3)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		CGTGTTCTAGGAAACCCTTCT	0.468000													149	15					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55110948	55110948	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:55110948C>T	ENST00000314721.2	+	1	322	c.272C>T	c.(271-273)tCc>tTc	p.S91F		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						ATCGCTATTTCCTTGTCAGCT	0.438000													113	169					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16150146	16150146	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:16150146C>T	ENST00000399408.2	+	12	1846	c.1671C>T	c.(1669-1671)ccC>ccT	p.P557P	ABCC1_ENST00000349029.5_Silent_p.P557P|ABCC1_ENST00000345148.5_Silent_p.P557P|ABCC1_ENST00000399410.3_Silent_p.P557P|ABCC1_ENST00000351154.5_Silent_p.P557P|ABCC1_ENST00000346370.5_Silent_p.P557P			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	557	ABC transmembrane type-1 1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TCTGCACGCCCTTTCTGGTGA	0.502000													20	19					0	0	1	0	0
ITFG3	83986	broad.mit.edu	37	16	314957	314957	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:314957G>A	ENST00000399932.3	+	13	2046	c.1595G>A	c.(1594-1596)gGg>gAg	p.G532E	ITFG3_ENST00000301678.3_Missense_Mutation_p.G532E|ITFG3_ENST00000301679.2_Intron|ITFG3_ENST00000442458.2_Intron|ITFG3_ENST00000600536.1_Intron|ITFG3_ENST00000450082.2_Intron			Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	532						integral to membrane				central_nervous_system(3)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				GGTGAGGGTGGGCCAGACAGT	0.667000													25	47					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50211045	50211045	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:50211045C>T	ENST00000284509.6	-	19	2167	c.2026G>A	c.(2026-2028)Gac>Aac	p.D676N	ATP8B4_ENST00000559829.1_Missense_Mutation_p.D676N	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	676					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CCTTGTTTGTCTCCTGTTAGG	0.333000													44	13					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231106160	231106160	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:231106160G>A	ENST00000392045.3	+	4	562	c.448G>A	c.(448-450)Gat>Aat	p.D150N	SP140_ENST00000486687.2_Missense_Mutation_p.D150N|SP140_ENST00000343805.6_Missense_Mutation_p.D150N|SP140_ENST00000417495.3_Missense_Mutation_p.D150N|SP140_ENST00000350136.5_Missense_Mutation_p.D130N|SP140_ENST00000420434.3_Missense_Mutation_p.D150N	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	150					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TAATGTAAACGATTTAGAAGA	0.378000													32	25					0	0	1	0	0
KCNK4	50801	broad.mit.edu	37	11	64064723	64064723	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:64064723G>A	ENST00000539216.1	+	3	806	c.446G>A	c.(445-447)gGc>gAc	p.G149D	KCNK4_ENST00000394525.2_Missense_Mutation_p.G149D|RP11-783K16.10_ENST00000539086.1_RNA|KCNK4_ENST00000422670.2_Missense_Mutation_p.G149D|KCNK4_ENST00000538767.1_Missense_Mutation_p.A83T|KCNK4_ENST00000539651.1_3'UTR			Q9NYG8	KCNK4_HUMAN	potassium channel, subfamily K, member 4	149						integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(2)|large_intestine(2)|lung(3)|prostate(2)|urinary_tract(1)	10						CTGCGCCATGGCATCGGTCAC	0.627000													45	42					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46867382	46867382	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:46867382G>A	ENST00000393382.3	-	10	1452	c.1311C>T	c.(1309-1311)atC>atT	p.I437I	TTLL6_ENST00000433608.2_Silent_p.I130I	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	389						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						TTTCCAGGTTGATCAGGACTA	0.512000													28	55					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3248173	3248173	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:3248173G>A	ENST00000217939.6	-	4	749	c.595C>T	c.(595-597)Cct>Tct	p.P199S		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	199						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ATGCTGGCAGGAAGAGTTCTA	0.483000													17	2					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152443716	152443716	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:152443716G>A	ENST00000367255.5	-	146	26850	c.26249C>T	c.(26248-26250)cCc>cTc	p.P8750L	SYNE1_ENST00000265368.4_Missense_Mutation_p.P8750L|ESR1_ENST00000544394.1_Intron|SYNE1_ENST00000356820.4_Missense_Mutation_p.P3274L|SYNE1_ENST00000539504.1_Missense_Mutation_p.P905L|SYNE1_ENST00000354674.4_Missense_Mutation_p.P928L|SYNE1_ENST00000423061.1_Missense_Mutation_p.P8702L|SYNE1_ENST00000341594.5_Missense_Mutation_p.P8362L|SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000448038.1_Missense_Mutation_p.P8702L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8750	KASH.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AAGCTGAAGGGGAAGAGCTGC	0.597000										HNSCC(10;0.0054)			25	52					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35066004	35066004	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:35066004C>T	ENST00000382002.5	-	10	1482	c.1056G>A	c.(1054-1056)ggG>ggA	p.G352G	PRLR_ENST00000513753.1_Intron|PRLR_ENST00000511486.1_Silent_p.G251G|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000231423.3_Intron|PRLR_ENST00000310101.5_Intron|PRLR_ENST00000342362.5_Silent_p.G251G|PRLR_ENST00000542609.1_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	352					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TGTCACAGCTCCCCCGGCCTG	0.498000													21	46					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	120387862	120387862	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:120387862G>A	ENST00000331113.4	+	6	2808	c.1843G>A	c.(1843-1845)Gaa>Aaa	p.E615K	RP4-797C5.2_ENST00000450480.1_RNA	NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	615					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					CGATAGGCCAGAATCCCCTGA	0.423000													25	24					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14852198	14852198	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:14852198G>A	ENST00000358984.4	+	36	4078	c.3898G>A	c.(3898-3900)Gag>Aag	p.E1300K		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1385										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						GGAGTCTCTGGAGCAGAAATT	0.353000													8	7					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64607904	64607904	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:64607904G>A	ENST00000498707.1	-	18	2998	c.2656C>T	c.(2656-2658)Cca>Tca	p.P886S	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.P858S	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	886	TSP type-1 2.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GCTTGCCATGGCCCATGACTG	0.373000													34	45					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27693801	27693801	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:27693801A>G	ENST00000260570.3	-	16	1789	c.1686T>C	c.(1684-1686)acT>acC	p.T562T		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	562					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					ATACCCTAATAGTGAACATGG	0.488000													26	31					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91714203	91714203	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:91714203C>T	ENST00000359028.2	+	35	9018	c.8793C>T	c.(8791-8793)ggC>ggT	p.G2931G	AKAP9_ENST00000358100.2_Intron|AKAP9_ENST00000356239.3_Silent_p.G2927G			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2931					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CATCAGAAGGCCGAGGAGAAG	0.353000			T	BRAF	papillary thyroid								74	101					0	0	1	0	0
ST6GALNAC3	256435	broad.mit.edu	37	1	77093151	77093151	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:77093151C>T	ENST00000328299.3	+	4	786	c.638C>T	c.(637-639)tCa>tTa	p.S213L		NM_152996.2	NP_694541.2	Q8NDV1	SIA7C_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	213					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|ovary(3)|prostate(1)|skin(2)	36						CAGTCTGGCTCATATCTCAGC	0.438000													54	90					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9258458	9258458	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:9258458C>T	ENST00000383440.2	+	8	5381	c.5124C>T	c.(5122-5124)atC>atT	p.I1708I	ANKRD12_ENST00000400020.3_Silent_p.I1708I|ANKRD12_ENST00000262126.3_Silent_p.I1731I	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	1731						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						AAAACCAAATCCCTCAAAGAA	0.338000													20	25					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6719397	6719397	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:6719397G>A	ENST00000245907.6	-	2	184	c.92C>T	c.(91-93)cCc>cTc	p.P31L		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	31					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CAAGATGTTGGGGGTGATGAT	0.617000													30	44					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78369253	78369253	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:78369253C>T	ENST00000278550.7	-	34	8622	c.8160G>A	c.(8158-8160)tgG>tgA	p.W2720*		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		CCCCCTCTGTCCAGGCCCGCA	0.662000													54	66					0	0	1	0	0
TRAV9-2	28677	broad.mit.edu	37	14	22409834	22409834	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:22409834C>T	ENST00000390441.2	+	0	380																											CGGTGTACTTCTGTGCTCTGA	0.537000													30	35					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84642162	84642162	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:84642162C>T	ENST00000284136.6	-	15	1747	c.1703_splice	c.e15-1	p.R568_splice	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	568	PSI.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						GTCTAGCTCTCCTGCGGAAAG	0.408000													44	44					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193029693	193029693	+	Missense_Mutation	SNP	C	C	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:193029693C>G	ENST00000342358.4	-	20	2474	c.2357G>C	c.(2356-2358)cGt>cCt	p.R786P	ATP13A5-AS1_ENST00000414634.1_RNA|ATP13A5_ENST00000495496.1_5'UTR	NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	786					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TCCTTCCCCACGAGGGGTTGA	0.413000													36	42					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8415576	8415576	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:8415576A>G	ENST00000337907.3	-	23	5204	c.4570T>C	c.(4570-4572)Tcg>Ccg	p.S1524P	RERE_ENST00000377464.1_Missense_Mutation_p.S1256P|RERE_ENST00000476556.1_Missense_Mutation_p.S970P|RERE_ENST00000400908.2_Missense_Mutation_p.S1524P|RERE_ENST00000400907.2_Missense_Mutation_p.S542P	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1524					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		AGCTCGGCCGACTGGGCATGC	0.627000													22	22					0	0	1	0	0
KRTAP5-1	387264	broad.mit.edu	37	11	1606189	1606189	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:1606189C>T	ENST00000382171.2	-	1	324	c.291G>A	c.(289-291)ggG>ggA	p.G97G	KRTAP5-AS1_ENST00000534077.1_RNA|KRTAP5-AS1_ENST00000532922.1_RNA|KRTAP5-AS1_ENST00000524947.1_RNA|KRTAP5-AS1_ENST00000424148.1_RNA	NM_001005922.1	NP_001005922.1	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	97	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(3)|kidney(1)|lung(9)|skin(2)|upper_aerodigestive_tract(1)	16		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGCCACAACCCCCCTTGGATC	0.677000													52	39					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100129904	100129904	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:100129904G>A	ENST00000394897.1	-	6	831	c.749C>T	c.(748-750)cCc>cTc	p.P250L	ADH6_ENST00000237653.7_Missense_Mutation_p.P250L|ADH6_ENST00000504257.1_5'UTR|RP11-696N14.1_ENST00000506160.1_RNA|RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000407820.2_Missense_Mutation_p.P41L|ADH6_ENST00000394899.2_Missense_Mutation_p.P250L			P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	250					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	TTCTTGAATGGGTTTCTTTAA	0.438000													193	271					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3432467	3432467	+	Splice_Site	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:3432467C>A	ENST00000602557.1	-	11	1902	c.1347_splice	c.e11+1	p.K449_splice	CSMD1_ENST00000539096.1_Splice_Site_p.K448_splice|CSMD1_ENST00000537824.1_Splice_Site_p.K448_splice|CSMD1_ENST00000542608.1_Splice_Site_p.K448_splice|CSMD1_ENST00000602723.1_Splice_Site_p.K449_splice|CSMD1_ENST00000400186.3_Splice_Site_p.K449_splice|CSMD1_ENST00000520002.1_Splice_Site_p.K449_splice			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	449	CUB 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGAGCCTTACCTTGTCCGGGT	0.522000													52	10					1.59911e-31	1.62103e-31	1	1	0
DGKI	9162	broad.mit.edu	37	7	137206704	137206704	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:137206704G>A	ENST00000453654.1	-	21	1795	c.1256C>T	c.(1255-1257)tCt>tTt	p.S419F	DGKI_ENST00000288490.5_Missense_Mutation_p.S719F|DGKI_ENST00000446122.1_Missense_Mutation_p.S719F|DGKI_ENST00000424189.2_Missense_Mutation_p.S740F			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	719	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						ATCTGGGACAGACTGGGGACT	0.453000													18	20					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38997970	38997970	+	Silent	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:38997970C>A	ENST00000359357.3	+	91	13529	c.13275C>A	c.(13273-13275)ctC>ctA	p.L4425L	DNAH8_ENST00000441566.1_Silent_p.L4389L					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CCAAGGTACTCTTCACGCAGT	0.517000											OREG0017409	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	68					0.000229342	0.000229637	1	1	0
CLEC16A	23274	broad.mit.edu	37	16	11065064	11065064	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:11065064C>T	ENST00000409790.1	+	5	805	c.575C>T	c.(574-576)aCc>aTc	p.T192I	CLEC16A_ENST00000409552.3_Missense_Mutation_p.T192I	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	192										breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GCTGTAAGAACCATAACTTTG	0.433000											OREG0023609	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	20					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76463644	76463644	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:76463644G>A	ENST00000396423.2	+	4	498	c.374G>A	c.(373-375)aGa>aAa	p.R125K	HNF4G_ENST00000354370.1_Missense_Mutation_p.R88K	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	88					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			GAACGTGACAGAATAAGCACC	0.418000													38	45					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99932104	99932104	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:99932104C>T	ENST00000524871.1	+	10	1431	c.1141C>T	c.(1141-1143)Cgt>Tgt	p.R381C	CNTN5_ENST00000528682.1_Missense_Mutation_p.R381C|CNTN5_ENST00000279463.3_Missense_Mutation_p.R381C|CNTN5_ENST00000418526.2_Missense_Mutation_p.R307C|CNTN5_ENST00000527185.1_Missense_Mutation_p.R381C	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	381	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AAATTCCTTTCGTGGACAATT	0.393000													29	40					0	0	1	0	0
NFE2	4778	broad.mit.edu	37	12	54686213	54686213	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:54686213G>A	ENST00000540264.2	-	2	1576	c.1067C>T	c.(1066-1068)gCc>gTc	p.A356V	NFE2_ENST00000312156.4_Missense_Mutation_p.A356V|NFE2_ENST00000435572.2_Missense_Mutation_p.A356V|RP11-968A15.8_ENST00000553061.1_RNA|NFE2_ENST00000553070.1_Missense_Mutation_p.A356V			Q16621	NFE2_HUMAN	nuclear factor, erythroid 2	356					blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(7)|upper_aerodigestive_tract(2)	16						GGTCCCATCGGCAGCCTGTTG	0.577000													19	60					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359170	66359170	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:66359170G>A	ENST00000333861.3	-	1	1384	c.1317C>T	c.(1315-1317)gtC>gtT	p.V439V		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	439										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CCTGGACCACGACCTCATTTC	0.552000													57	58					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167793728	167793728	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:167793728G>A	ENST00000367848.1	-	28	4259	c.3762C>T	c.(3760-3762)ctC>ctT	p.L1254L	ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Silent_p.L1346L|ADCY10_ENST00000545172.1_Silent_p.L1193L			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1346					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TGTTCAGAAGGAGACATCTGC	0.468000													112	141					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966399	41966399	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:41966399C>T	ENST00000298919.7	+	10	1426	c.1038C>T	c.(1036-1038)ctC>ctT	p.L346L	PDZRN4_ENST00000539469.2_Silent_p.L348L|PDZRN4_ENST00000402685.2_Silent_p.L606L			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	606							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				ATGAGAGCCTCGTATCTGGTG	0.488000													24	24					0	0	1	0	0
FOCAD	54914	broad.mit.edu	37	9	20981651	20981651	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:20981651G>A	ENST00000380249.1	+	40	4968	c.4604G>A	c.(4603-4605)gGg>gAg	p.G1535E	FOCAD_ENST00000605086.1_Missense_Mutation_p.G971E|FOCAD_ENST00000338382.6_Missense_Mutation_p.G1535E	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	1535						integral to membrane	binding										GAAGCTACTGGGAAAATTTTT	0.463000													28	6					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93101730	93101730	+	Missense_Mutation	SNP	G	G	A	rs138829125		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:93101730G>A	ENST00000359558.2	-	7	739	c.440C>T	c.(439-441)tCc>tTc	p.S147F	CALCR_ENST00000421592.1_Missense_Mutation_p.S129F|CALCR_ENST00000394441.1_Missense_Mutation_p.S129F|CALCR_ENST00000360249.4_Missense_Mutation_p.S129F|CALCR_ENST00000426151.1_Missense_Mutation_p.S129F	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	129					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	AGTATAGTTGGACCAGGTTCG	0.338000													42	75					0	0	1	0	0
TRA2A	29896	broad.mit.edu	37	7	23555982	23555982	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:23555982C>T	ENST00000297071.4	-	3	552	c.336_splice	c.e3+1	p.R112_splice	TRA2A_ENST00000538367.1_Splice_Site_p.R11_splice|TRA2A_ENST00000474586.1_5'UTR|TRA2A_ENST00000392502.4_Splice_Site_p.R11_splice	NM_013293.3	NP_037425.1	Q13595	TRA2A_HUMAN	transformer 2 alpha homolog (Drosophila)	112	Arg/Ser-rich (RS1 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	10						AACCACGTACCCTGCTGCCAG	0.433000													21	35					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119031618	119031618	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:119031618G>A	ENST00000307417.3	+	15	2107	c.1743G>A	c.(1741-1743)acG>acA	p.T581T	ABCG4_ENST00000531739.1_Silent_p.T581T|ABCG4_ENST00000449422.2_Silent_p.T581T	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	581	ABC transmembrane type-2.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity	p.T581T(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TGATCCTGACGATCTATGGCA	0.572000													22	23					0	0	1	0	0
TOX	9760	broad.mit.edu	37	8	59851926	59851926	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:59851926G>A	ENST00000361421.1	-	3	566	c.346C>T	c.(346-348)Cct>Tct	p.P116S		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	116						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				GTGATTTCAGGGAGGTCCATG	0.478000													66	56					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16711089	16711089	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:16711089G>A	ENST00000513610.1	-	21	2551	c.2097C>T	c.(2095-2097)gtC>gtT	p.V699V	MYO10_ENST00000505695.1_Silent_p.V38V|MYO10_ENST00000274203.9_Silent_p.V56V|MYO10_ENST00000512061.1_5'UTR|MYO10_ENST00000427430.2_Silent_p.V56V|MYO10_ENST00000515803.1_Silent_p.V38V	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	699	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						ACTTCCCTCGGACGTCCTCAG	0.557000													15	4					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183600941	183600941	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:183600941C>T	ENST00000511685.1	+	8	1572	c.1449C>T	c.(1447-1449)atC>atT	p.I483I	TENM3_ENST00000406950.2_Silent_p.I483I					teneurin transmembrane protein 3																		CCGGCTTTATCCAGTACTTGG	0.502000													21	32					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107569953	107569953	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:107569953C>T	ENST00000393561.1	-	28	4905	c.4721G>A	c.(4720-4722)cGa>cAa	p.R1574Q	LAMB1_ENST00000474380.1_5'UTR|LAMB1_ENST00000222399.6_Missense_Mutation_p.R1550Q			P07942	LAMB1_HUMAN	laminin, beta 1	1550	Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTTTCAACTCGTTCACGTAT	0.418000													43	67					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42532485	42532485	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:42532485G>A	ENST00000282030.5	+	4	3476	c.3180G>A	c.(3178-3180)atG>atA	p.M1060I		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	1060						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CAATGCCTATGATGAACCTTG	0.488000									Schinzel-Giedion syndrome				21	33					0	0	1	0	0
YBX3	8531	broad.mit.edu	37	12	10856714	10856714	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:10856714G>A	ENST00000228251.4	-	7	1014	c.814C>T	c.(814-816)Cca>Tca	p.P272S	YBX3_ENST00000279550.7_Missense_Mutation_p.P203S|YBX3_ENST00000546164.1_5'UTR	NM_003651.4	NP_003642.3			Y box binding protein 3																		GCTCCCTCTGGGACTCCATCC	0.507000													41	31					0	0	1	0	0
CASP10	843	broad.mit.edu	37	2	202082378	202082378	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:202082378G>A	ENST00000286186.6	+	10	1918	c.1483G>A	c.(1483-1485)Gga>Aga	p.G495R	CASP10_ENST00000346817.5_Missense_Mutation_p.G452R|CASP10_ENST00000492363.1_3'UTR|CASP10_ENST00000272879.5_Intron|CASP10_ENST00000313728.7_Missense_Mutation_p.G428R|CASP10_ENST00000360132.3_3'UTR|CASP10_ENST00000448480.1_Intron	NM_032977.3	NP_116759.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	0					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						GGACAAACAGGGAACAAAGAA	0.403000													51	109					0	0	1	0	0
MCPH1	79648	broad.mit.edu	37	8	6302682	6302682	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:6302682C>T	ENST00000344683.5	+	8	1515	c.1439C>T	c.(1438-1440)aCc>aTc	p.T480I	MCPH1_ENST00000522905.1_Missense_Mutation_p.T432I|MCPH1_ENST00000519480.1_Missense_Mutation_p.T480I	NM_024596.3	NP_078872.2	Q8NEM0	MCPH1_HUMAN	microcephalin 1	480						microtubule organizing center			AGPAT5/MCPH1(2)	central_nervous_system(1)|large_intestine(4)|skin(1)	6		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		ACAGCAAAAACCATCTCCAGT	0.443000													34	13					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119474366	119474366	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:119474366C>T	ENST00000369429.3	-	2	304	c.295G>A	c.(295-297)Gct>Act	p.A99T	TBX15_ENST00000207157.3_5'UTR			Q96SF7	TBX15_HUMAN	T-box 15	99						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GGGCCTGCAGCACCAGAGGCC	0.532000													21	27					0	0	1	0	0
NKAIN3	286183	broad.mit.edu	37	8	63659497	63659497	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:63659497G>A	ENST00000523211.1	+	4	412	c.280G>A	c.(280-282)Gat>Aat	p.D94N	NKAIN3_ENST00000519049.1_3'UTR|NKAIN3_ENST00000328472.5_Missense_Mutation_p.D94N	NM_173688.2	NP_775959.1	Q8N8D7	NKAI3_HUMAN	Na+/K+ transporting ATPase interacting 3	94						integral to membrane|plasma membrane				kidney(3)|large_intestine(2)|lung(8)	13	Breast(64;0.127)	Lung NSC(129;0.187)				CTAGGACACCGATCTAATGAC	0.448000													45	32					0	0	1	0	0
CACHD1	57685	broad.mit.edu	37	1	65141605	65141605	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:65141605C>T	ENST00000371073.2	+	21	2914	c.2914C>T	c.(2914-2916)Cct>Tct	p.P972S	CACHD1_ENST00000290039.5_Missense_Mutation_p.P921S|CACHD1_ENST00000495994.1_3'UTR			Q5VU97	CAHD1_HUMAN	cache domain containing 1	972	Cys-rich.				calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						ATGTGAATGTCCTTGTGAGTG	0.358000													12	22					0	0	1	0	0
JAK1	3716	broad.mit.edu	37	1	65310460	65310460	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:65310460G>A	ENST00000342505.4	-	16	2476	c.2228C>T	c.(2227-2229)cCc>cTc	p.P743L	JAK1_ENST00000465376.1_5'UTR	NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	743	Protein kinase 1.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		CACCGTAATGGGGATGCCGGG	0.597000			Mis		ALL								35	36					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179477716	179477716	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179477716C>T	ENST00000589042.1	-	265	49956	c.49732G>A	c.(49732-49734)Gat>Aat	p.D16578N	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D14937N|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D7638N|TTN_ENST00000342992.6_Missense_Mutation_p.D14010N|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D7513N|TTN_ENST00000342175.6_Missense_Mutation_p.D7705N|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589234.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14937	Fibronectin type-III 20.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCACCTCCATCATGTTCTGGT	0.458000													60	35					0	0	1	0	0
TREM1	54210	broad.mit.edu	37	6	41248702	41248702	+	Missense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:41248702A>T	ENST00000591620.1	-	3	622	c.596T>A	c.(595-597)aTc>aAc	p.I199N	TREM1_ENST00000244709.4_Missense_Mutation_p.I199N|TREM1_ENST00000589614.1_Missense_Mutation_p.I199N|TREM1_ENST00000334475.6_Intron	NM_001242589.1	NP_001229518.1	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	199					blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			NS(1)|breast(2)|endometrium(2)|large_intestine(5)|lung(5)|skin(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	ACTATACCTGATGATATCTGT	0.512000													19	43					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86959202	86959202	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:86959202C>T	ENST00000234701.3	+	11	1951	c.1600C>T	c.(1600-1602)Ccc>Tcc	p.P534S	CLCA1_ENST00000394711.1_Missense_Mutation_p.P534S			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	534					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		TCTCTGGGATCCCAGTGGACA	0.488000													44	52					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4735308	4735308	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:4735308C>T	ENST00000354582.6	+	33	4514	c.4164C>T	c.(4162-4164)gtC>gtT	p.V1388V	ITPR1_ENST00000357086.4_Silent_p.V1379V|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000456211.2_Silent_p.V1364V|ITPR1_ENST00000443694.2_Silent_p.V1373V|ITPR1_ENST00000302640.8_Silent_p.V1373V|ITPR1_ENST00000423119.2_Silent_p.V1379V			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	1388					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TCCACTTGGTCGAGCTCCTGG	0.552000													35	48					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55279598	55279598	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:55279598C>T	ENST00000358193.3	+	7	928	c.874C>T	c.(874-876)Cct>Tct	p.P292S	C1orf177_ENST00000371273.3_Missense_Mutation_p.P292S	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	292										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						CCCGAAAACCCCTACAGAGAG	0.507000													47	99					0	0	1	0	0
PCOLCE2	26577	broad.mit.edu	37	3	142539803	142539803	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:142539803C>T	ENST00000295992.3	-	8	1340	c.1034G>A	c.(1033-1035)gGa>gAa	p.G345E	PCOLCE2_ENST00000485766.1_Silent_p.G265G	NM_013363.3	NP_037495.1	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	345	NTR.					extracellular region	collagen binding|heparin binding|peptidase activator activity	p.G345E(1)		NS(1)|endometrium(1)|large_intestine(11)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	32						CGCCAAATTTCCCTCTTTGTA	0.507000													24	40					0	0	1	0	0
PODXL2	50512	broad.mit.edu	37	3	127379952	127379952	+	Missense_Mutation	SNP	G	G	A	rs151077692		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:127379952G>A	ENST00000342480.6	+	3	1120	c.1081G>A	c.(1081-1083)Gaa>Aaa	p.E361K		NM_015720.2	NP_056535.1	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2	361					leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	26						GCAGCTCCTAGAAGGGCAGGC	0.567000													37	35					0	0	1	0	0
STEAP2	261729	broad.mit.edu	37	7	89861844	89861844	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:89861844G>A	ENST00000287908.3	+	5	1772	c.1379G>A	c.(1378-1380)cGa>cAa	p.R460Q	STEAP2_ENST00000402625.2_Intron|STEAP2_ENST00000394622.2_Missense_Mutation_p.R460Q|STEAP2_ENST00000394632.1_Intron|STEAP2_ENST00000394621.2_Missense_Mutation_p.R460Q|STEAP2_ENST00000394626.1_Intron|STEAP2_ENST00000394629.2_Intron	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	460					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					AAGCTAAAACGAATTAAAAAA	0.398000													21	24					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14284353	14284353	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:14284353G>A	ENST00000310358.7	+	0	2627							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GATCCAAATGGAGCCTCAGTT	0.537000													17	26					0	0	1	0	0
HEATR6	63897	broad.mit.edu	37	17	58144812	58144812	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:58144812G>A	ENST00000184956.6	-	8	1237	c.1221C>T	c.(1219-1221)ggC>ggT	p.G407G	HEATR6_ENST00000585976.1_Silent_p.G407G	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	407							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			TACTCTGCATGCCTCCTTCAG	0.393000													55	58					0	0	1	0	0
GGH	8836	broad.mit.edu	37	8	63936713	63936713	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:63936713G>A	ENST00000260118.6	-	6	934	c.532C>T	c.(532-534)Cct>Tct	p.P178S	GGH_ENST00000518113.1_5'UTR	NM_003878.2	NP_003869.1	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	178	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity			breast(1)|kidney(1)|large_intestine(1)|liver(1)|lung(6)|stomach(1)	11	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	AACTCAGTAGGAAAATTCTGG	0.353000													33	47					0	0	1	0	0
HPSE2	60495	broad.mit.edu	37	10	100374730	100374730	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:100374730G>A	ENST00000370552.3	-	9	1310	c.1251C>T	c.(1249-1251)gtC>gtT	p.V417V	HPSE2_ENST00000404542.1_Silent_p.V305V|HPSE2_ENST00000370546.1_Silent_p.V417V|HPSE2_ENST00000370549.1_Silent_p.V359V	NM_021828.4	NP_068600.4	Q8WWQ2	HPSE2_HUMAN	heparanase 2	417					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	40				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		GCCGTATCACGACATCAATGC	0.388000													59	11					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109605814	109605814	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:109605814C>T	ENST00000338432.7	+	4	1019	c.900C>T	c.(898-900)acC>acT	p.T300T	ACACB_ENST00000377854.5_Silent_p.T300T|ACACB_ENST00000377848.3_Silent_p.T300T			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	300	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	TGATGGTGACCCCCGAGGACC	0.627000													15	44					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058985	152058985	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:152058985C>T	ENST00000368806.1	-	3	1237	c.1173G>A	c.(1171-1173)agG>agA	p.R391R		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	391							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TCCTCTCTTTCCTTTCATCTC	0.473000													111	127					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77377180	77377180	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:77377180C>T	ENST00000451710.3	-	26	4644	c.4407G>A	c.(4405-4407)aaG>aaA	p.K1469K	TRPM6_ENST00000449912.2_Silent_p.K1464K|TRPM6_ENST00000376864.4_Silent_p.K1469K|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000360774.1_Silent_p.K1469K|TRPM6_ENST00000361255.3_Silent_p.K1464K|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1469					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K1469K(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						GCCACTTTTTCTTGATGCTAA	0.488000													72	6					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48744443	48744443	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:48744443T>A	ENST00000314191.2	-	61	8250	c.8194A>T	c.(8194-8196)Atg>Ttg	p.M2732L	PRKDC_ENST00000338368.3_Missense_Mutation_p.M2732L|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2733	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGGTCCCTCATAAACCGTCTG	0.547000								Non-homologous end-joining					171	217					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157454325	157454325	+	Missense_Mutation	SNP	C	C	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:157454325C>G	ENST00000346085.5	+	8	2536	c.2535C>G	c.(2533-2535)agC>agG	p.S845R	ARID1B_ENST00000367148.1_Missense_Mutation_p.S832R|ARID1B_ENST00000350026.5_Missense_Mutation_p.S832R|ARID1B_ENST00000275248.4_Missense_Mutation_p.S774R	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	832					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CACAGATGAGCCAGTATGGAC	0.448000													14	30					0	0	1	0	0
SEC63	11231	broad.mit.edu	37	6	108224095	108224095	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:108224095G>A	ENST00000369002.4	-	12	1341	c.1162C>T	c.(1162-1164)Cct>Tct	p.P388S		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	388	SEC63 1.				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TCAATATGAGGGAGCTGCAGA	0.423000													43	87					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201058480	201058480	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:201058480T>C	ENST00000362061.3	-	6	1032	c.806A>G	c.(805-807)aAc>aGc	p.N269S	CACNA1S_ENST00000367338.3_Missense_Mutation_p.N269S	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	269					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GATGCCATGGTTGGGCCCTGG	0.622000													20	28					0	0	1	0	0
ADH4	127	broad.mit.edu	37	4	100047751	100047751	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:100047751C>T	ENST00000508393.1	-	9	1334	c.1169G>A	c.(1168-1170)gGa>gAa	p.G390E	ADH4_ENST00000505590.1_Missense_Mutation_p.G390E|ADH4_ENST00000265512.7_Missense_Mutation_p.G371E|ADH4_ENST00000423445.1_Missense_Mutation_p.G390E|RP11-696N14.1_ENST00000500358.2_RNA			P08319	ADH4_HUMAN	alcohol dehydrogenase 4 (class II), pi polypeptide	371					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			NS(1)|cervix(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)|skin(2)	18				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	GTACCTTTTTCCTTGGTTCAT	0.343000													39	50					0	0	1	0	0
KIAA0895L	653319	broad.mit.edu	37	16	67213944	67213944	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:67213944C>T	ENST00000290881.7	-	3	1496	c.570_splice	c.e3+1	p.Q190_splice	KIAA0895L_ENST00000561621.1_Splice_Site_p.Q190_splice|KIAA0895L_ENST00000563902.1_Splice_Site_p.Q190_splice|KIAA0895L_ENST00000563831.2_Intron			Q68EN5	K895L_HUMAN	KIAA0895-like	190										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						CTGGACTGACCTGATGGATGA	0.582000													31	47					0	0	1	0	0
RAD51B	5890	broad.mit.edu	37	14	68331730	68331730	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:68331730C>T	ENST00000487270.1	+	5	374	c.326C>T	c.(325-327)cCa>cTa	p.P109L	RAD51B_ENST00000488612.1_Missense_Mutation_p.P109L|RAD51B_ENST00000471583.1_Missense_Mutation_p.P109L|RAD51B_ENST00000487861.1_Missense_Mutation_p.P109L|RAD51B_ENST00000390683.3_Missense_Mutation_p.P109L	NM_133509.3	NP_598193.2	O15315	RA51B_HUMAN	RAD51 paralog B	109					blood coagulation|DNA repair|reciprocal meiotic recombination	nucleoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity		HMGA2/RAD51B(11)	breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	11						ATTACAGGTCCACCAGGTTGT	0.313000								Direct reversal of damage					5	8					0	0	1	0	0
RGS8	85397	broad.mit.edu	37	1	182615927	182615927	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:182615927G>A	ENST00000483095.2	-	7	743	c.486C>T	c.(484-486)ttC>ttT	p.F162F	RGS8_ENST00000367556.1_Silent_p.F162F|RGS8_ENST00000367557.4_Silent_p.F162F|RGS8_ENST00000258302.4_Silent_p.F180F			P57771	RGS8_HUMAN	regulator of G-protein signaling 8	162	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	5						TGGACCTCAGGAACCTGGGGT	0.522000													67	85					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94029571	94029571	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:94029571G>A	ENST00000297268.6	+	5	667	c.196G>A	c.(196-198)Ggt>Agt	p.G66S		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	66					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TGGTCCACCTGGTCCTCCTGG	0.502000										HNSCC(75;0.22)			63	47					0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164507036	164507036	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:164507036G>A	ENST00000503008.1	-	6	1264	c.288C>T	c.(286-288)ccC>ccT	p.P96P	MARCH1_ENST00000514618.1_Silent_p.P352P|MARCH1_ENST00000274056.7_Silent_p.P96P|MARCH1_ENST00000339875.5_Silent_p.P79P	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	96					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGCAGCGACAGGGTGTGATGA	0.542000													26	49					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89772259	89772259	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:89772259G>A	ENST00000264344.5	-	7	1126	c.919C>T	c.(919-921)Cag>Tag	p.Q307*	FAM13A_ENST00000511976.1_Intron|FAM13A_ENST00000502459.1_5'UTR	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	307					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						AAGCTGAGCTGAGGAATGCCA	0.468000													76	104					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65266269	65266269	+	RNA	SNP	T	T	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:65266269T>G	ENST00000534336.1	+	0	1037					NR_002819.2																						ATGATTTCCATGTTTCTTTTG	0.363000													92	114					0	0	1	0	0
RASSF6	166824	broad.mit.edu	37	4	74459252	74459252	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:74459252C>T	ENST00000307439.5	-	4	497	c.203G>A	c.(202-204)cGa>cAa	p.R68Q	RASSF6_ENST00000395777.2_Missense_Mutation_p.R68Q|RASSF6_ENST00000342081.3_Missense_Mutation_p.R100Q|RASSF6_ENST00000335049.5_Missense_Mutation_p.R56Q	NM_001270391.1|NM_177532.4	NP_001257320.1|NP_803876.1	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family member 6	100					apoptosis|signal transduction		protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|pancreas(2)|skin(2)	17	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			CTGTATAGGTCGTTTTACTCC	0.363000													61	59					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71913605	71913605	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:71913605G>A	ENST00000258104.3	+	55	6503	c.6226G>A	c.(6226-6228)Gtg>Atg	p.V2076M	DYSF_ENST00000409744.1_Missense_Mutation_p.V2084M|DYSF_ENST00000409651.1_Missense_Mutation_p.V2108M|DYSF_ENST00000409762.1_Missense_Mutation_p.V2093M|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000409366.1_Missense_Mutation_p.V2098M|DYSF_ENST00000413539.2_Missense_Mutation_p.V2107M|DYSF_ENST00000429174.2_Missense_Mutation_p.V2097M|DYSF_ENST00000410041.1_Missense_Mutation_p.V2094M|DYSF_ENST00000409582.3_Missense_Mutation_p.V2114M|DYSF_ENST00000410020.3_Missense_Mutation_p.V2115M|DYSF_ENST00000394120.2_Missense_Mutation_p.V2077M	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	2076						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CATGAAGCTGGTGAAGCCCTT	0.657000													87	121					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110530694	110530694	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:110530694G>A	ENST00000378402.5	+	73	12092	c.11988G>A	c.(11986-11988)gaG>gaA	p.E3996E		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3996					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTGAAATAGAGATTGGAGACC	0.398000										HNSCC(38;0.096)			40	43					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1250322	1250322	+	Silent	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:1250322C>A	ENST00000348261.5	+	7	1118	c.870C>A	c.(868-870)atC>atA	p.I290I	CACNA1H_ENST00000358590.4_Silent_p.I290I|CACNA1H_ENST00000565831.1_Silent_p.I290I	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	290					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	ACCCGTTCATCTGCTCCTCAC	0.652000													11	3					9.70103e-10	9.74495e-10	1	1	0
C11orf88	399949	broad.mit.edu	37	11	111407520	111407520	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:111407520G>A	ENST00000332814.6	+	7	559	c.559G>A	c.(559-561)Gag>Aag	p.E187K	C11orf88_ENST00000529167.1_3'UTR|C11orf88_ENST00000375618.4_Missense_Mutation_p.E160K	NM_207430.2	NP_997313.2	Q6PI97	CK088_HUMAN	chromosome 11 open reading frame 88	160										endometrium(1)|large_intestine(3)|lung(2)	6						GTCAGATAAAGAGGACCAAGA	0.403000													28	39					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113379462	113379462	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:113379462G>A	ENST00000316407.4	-	7	1477	c.1067C>T	c.(1066-1068)cCa>cTa	p.P356L	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Missense_Mutation_p.P356L	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	356					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						AATGCTCATTGGAGAAGAATC	0.473000													25	47					0	0	1	0	0
SMYD3	64754	broad.mit.edu	37	1	245912889	245912889	+	Silent	SNP	G	G	A	rs139195102	by1000genomes	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:245912889G>A	ENST00000490107.1	-	12	1302	c.1086C>T	c.(1084-1086)tgC>tgT	p.C362C	SMYD3_ENST00000388985.4_Silent_p.C421C|SMYD3_ENST00000541742.1_Silent_p.C362C|SMYD3_ENST00000366517.1_5'UTR	NM_001167740.1	NP_001161212.1	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	421						cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding	p.C362C(1)		breast(3)|large_intestine(5)|lung(8)|skin(1)	17	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		TGTTGGCGTCGCATTCTTCTA	0.433000													5	70					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113308503	113308503	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:113308503C>T	ENST00000401783.2	-	3	1192	c.856G>A	c.(856-858)Gac>Aac	p.D286N	SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000302728.8_Missense_Mutation_p.D286N|SVEP1_ENST00000374461.1_Missense_Mutation_p.D263N|SVEP1_ENST00000374469.1_Missense_Mutation_p.D263N	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	286					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TCACAGCAGTCCTTGCCTTCA	0.438000													8	1					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873570	36873570	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:36873570C>T	ENST00000301807.6	-	21	7619	c.5722G>A	c.(5722-5724)Gat>Aat	p.D1908N	TRANK1_ENST00000429976.2_Missense_Mutation_p.D2458N|TRANK1_ENST00000428977.2_Missense_Mutation_p.D1908N	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2458					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GAGAACACATCCCCAAGCTCC	0.502000													55	74					0	0	1	0	0
PGLYRP3	114771	broad.mit.edu	37	1	153276366	153276366	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:153276366G>A	ENST00000290722.1	-	4	548	c.496C>T	c.(496-498)Ctg>Ttg	p.L166L		NM_052891.1	NP_443123.1	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3	166					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(1)|liver(1)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	28	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGAGGGTCCAGGCAGGTCTCT	0.537000													33	48					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28672105	28672105	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:28672105C>T	ENST00000280904.6	-	3	756	c.313G>A	c.(313-315)Gaa>Aaa	p.E105K	DSC2_ENST00000251081.6_Missense_Mutation_p.E105K	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	105					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TTCTTCTTTTCTTGGTTCTCA	0.323000													51	56					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46924403	46924403	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:46924403G>A	ENST00000429979.1	-	11	2018	c.1414C>T	c.(1414-1416)Cct>Tct	p.P472S	KIAA0226L_ENST00000378787.3_Missense_Mutation_p.P472S|KIAA0226L_ENST00000378797.2_Missense_Mutation_p.P472S|KIAA0226L_ENST00000409879.2_Missense_Mutation_p.P315S|KIAA0226L_ENST00000378784.4_Missense_Mutation_p.P405S|KIAA0226L_ENST00000378781.3_3'UTR|KIAA0226L_ENST00000389908.3_Missense_Mutation_p.P472S|KIAA0226L_ENST00000322896.6_Missense_Mutation_p.P315S|KIAA0226L_ENST00000534925.1_Missense_Mutation_p.P337S	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	472										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						ATTCGGGCAGGGATGCACGAC	0.498000													5	10					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234452443	234452443	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:234452443G>A	ENST00000366618.3	+	5	1069	c.924G>A	c.(922-924)gtG>gtA	p.V308V	SLC35F3_ENST00000366617.3_Silent_p.V239V	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	239					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			CACTGGTGGTGGCCTCAGCAT	0.602000													91	116					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	96025626	96025626	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:96025626C>T	ENST00000260766.3	+	16	4826	c.4192C>T	c.(4192-4194)Ctc>Ttc	p.L1398F	PLCE1_ENST00000371380.2_Missense_Mutation_p.L1398F|PLCE1_ENST00000371385.3_Missense_Mutation_p.L1090F|PLCE1_ENST00000371375.1_Missense_Mutation_p.L1090F	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1398	PI-PLC X-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				GCAGCTACCCCTCTCATACTA	0.413000													39	13					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3141982	3141982	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:3141982G>A	ENST00000400569.3	-	14	2313	c.1980C>T	c.(1978-1980)ccC>ccT	p.P660P	MYOM1_ENST00000356443.4_Silent_p.P660P|MYOM1_ENST00000261606.7_Silent_p.P660P			P52179	MYOM1_HUMAN	myomesin 1	660	Fibronectin type-III 2.					striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GCTGGCCAGGGGGCTTCCAGC	0.498000													44	67					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19486690	19486690	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:19486690G>A	ENST00000375267.2	-	39	5495	c.5492C>T	c.(5491-5493)gCc>gTc	p.A1831V	UBR4_ENST00000375254.3_Missense_Mutation_p.A1831V|UBR4_ENST00000375226.2_Missense_Mutation_p.A1831V|UBR4_ENST00000375217.2_Missense_Mutation_p.A1831V			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	1831					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GCTCCCGACGGCTGAAGCTTG	0.517000													32	28					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40727112	40727112	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:40727112G>A	ENST00000373198.3	-	28	4096	c.3861C>T	c.(3859-3861)ttC>ttT	p.F1287F	PTPRT_ENST00000373190.1_Silent_p.F1264F|PTPRT_ENST00000373187.1_Silent_p.F1265F|PTPRT_ENST00000373201.1_Silent_p.F1255F|PTPRT_ENST00000373184.1_Silent_p.F1275F|PTPRT_ENST00000356100.2_Silent_p.F1274F|PTPRT_ENST00000373193.3_Silent_p.F1268F	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1265	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity	p.F1287F(1)		NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGTTGTAATCGAACACCAGCC	0.592000													41	53					0	0	1	0	0
SERTAD3	29946	broad.mit.edu	37	19	40947746	40947746	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:40947746G>A	ENST00000322354.3	-	2	738	c.242C>T	c.(241-243)cCc>cTc	p.P81L	SERTAD3_ENST00000392028.4_Missense_Mutation_p.P81L	NM_203344.2	NP_976219.1	Q9UJW9	SRTD3_HUMAN	SERTA domain containing 3	81					negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			kidney(1)|large_intestine(4)|lung(2)	7			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CAGGAAGAGGGGCTCGGGGGG	0.642000													31	28					0	0	1	0	0
BCO2	83875	broad.mit.edu	37	11	112084482	112084482	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:112084482G>A	ENST00000357685.5	+	9	1365	c.1230G>A	c.(1228-1230)agG>agA	p.R410R	BCO2_ENST00000438022.1_Silent_p.R376R|BCO2_ENST00000393032.2_Silent_p.R376R|BCO2_ENST00000361053.4_Silent_p.R337R|BCO2_ENST00000531169.1_Silent_p.R376R|BCO2_ENST00000526088.1_Silent_p.R376R|BCO2_ENST00000532593.1_Silent_p.R305R			Q9BYV7	BCDO2_HUMAN	beta-carotene oxygenase 2	410					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)	16						TCCCTCGAAGGTTTGTTTTGC	0.413000													87	142					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76528873	76528873	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:76528873C>T	ENST00000307431.8	+	15	2529	c.2144C>T	c.(2143-2145)tCg>tTg	p.S715L	CNTNAP4_ENST00000377504.4_Missense_Mutation_p.S667L|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.S643L|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.S719L|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	716	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding	p.S691L(2)|p.S643L(2)		breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GGAGGTTCTTCGCCTGATCTT	0.423000													52	70					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54958874	54958874	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:54958874C>T	ENST00000273286.5	-	2	538	c.376G>A	c.(376-378)Gag>Aag	p.E126K	CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000490478.1_Intron|LRTM1_ENST00000493075.1_Missense_Mutation_p.E50K|CACNA2D3_ENST00000474759.1_Intron|CACNA2D3_ENST00000288197.5_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	126						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		AAATCAAGCTCCCTCAGCTGA	0.463000													36	48					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29779929	29779929	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:29779929C>T	ENST00000375398.2	-	24	4488	c.4039G>A	c.(4039-4041)Gag>Aag	p.E1347K	SVIL_ENST00000535393.1_Missense_Mutation_p.E261K|SVIL_ENST00000355867.4_Missense_Mutation_p.E1347K|SVIL_ENST00000375400.3_Missense_Mutation_p.E921K|SVIL_ENST00000538146.1_Missense_Mutation_p.E139K			O95425	SVIL_HUMAN	supervillin	1347					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding	p.E1347K(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CGCTTGTGCTCGGCCACGGAA	0.592000													7	20					0	0	1	0	0
SRL	6345	broad.mit.edu	37	16	4254582	4254582	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:4254582C>T	ENST00000399609.3	-	2	127	c.115G>A	c.(115-117)Gag>Aag	p.E39K	SRL_ENST00000537996.1_5'UTR	NM_001098814.1	NP_001092284.1	Q86TD4	SRCA_HUMAN	sarcalumenin	498	Acidic domain, probably binds calcium (By similarity).					sarcoplasmic reticulum lumen	GTP binding|GTPase activity	p.E39K(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(3)	21						AGGGTCTTCTCGATGTGGGAG	0.572000													34	64					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458252	248458252	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:248458252G>A	ENST00000317996.1	-	1	628	c.629C>T	c.(628-630)tCc>tTc	p.S210F		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			CAGGATGAGGGAAAAGGGGAC	0.547000													35	12					0	0	1	0	0
ARID5A	10865	broad.mit.edu	37	2	97217908	97217908	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:97217908C>T	ENST00000454558.2	+	7	2616	c.1439C>T	c.(1438-1440)gCc>gTc	p.A480V	ARID5A_ENST00000357485.3_Missense_Mutation_p.A548V			Q03989	ARI5A_HUMAN	AT rich interactive domain 5A (MRF1-like)	548					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|skin(1)|urinary_tract(2)	14						TCGCCCATGGCCGCTGGCCTG	0.697000													90	141					0	0	1	0	0
HELQ	113510	broad.mit.edu	37	4	84337938	84337938	+	Missense_Mutation	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:84337938C>A	ENST00000295488.3	-	17	3306	c.3144G>T	c.(3142-3144)agG>agT	p.R1048S	HELQ_ENST00000510985.1_Missense_Mutation_p.R981S	NM_133636.2	NP_598375.2	Q8TDG4	HELQ_HUMAN	helicase, POLQ-like	1048							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(17)|ovary(2)|skin(2)	38						GATCAATTGTCCTTACGAGCA	0.363000								Other identified genes with known or suspected DNA repair function					62	70					6.20203e-27	6.28295e-27	1	1	0
CDH6	1004	broad.mit.edu	37	5	31317546	31317546	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:31317546C>T	ENST00000265071.2	+	10	1842	c.1577C>T	c.(1576-1578)tCc>tTc	p.S526F	CDH6_ENST00000514738.1_Missense_Mutation_p.S471F	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	526	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TTTTCGTTTTCCTTGGCCCCT	0.413000													54	37					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16597413	16597413	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:16597413C>T	ENST00000502640.1	-	3	469	c.321G>A	c.(319-321)tcG>tcA	p.S107S	LDB2_ENST00000503829.1_5'UTR|LDB2_ENST00000441778.2_Silent_p.S107S|LDB2_ENST00000503178.2_5'UTR|LDB2_ENST00000515064.1_Silent_p.S107S|LDB2_ENST00000304523.5_Silent_p.S107S			O43679	LDB2_HUMAN	LIM domain binding 2	107							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						ATGACTCTTTCGAGTGTTTGA	0.527000													38	45					0	0	1	0	0
ERAS	3266	broad.mit.edu	37	X	48687974	48687974	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:48687974C>T	ENST00000338270.1	+	1	692	c.441C>T	c.(439-441)gtC>gtT	p.V147V		NM_181532.2	NP_853510.1	Q7Z444	RASE_HUMAN	ES cell expressed Ras	147					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			endometrium(2)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	14						AGCCCCTTGTCCTCGTGGGCA	0.642000													23	1					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70224280	70224280	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:70224280C>T	ENST00000253925.7	+	26	3744	c.3529C>T	c.(3529-3531)Cca>Tca	p.P1177S	AP000487.5_ENST00000500185.2_RNA|PPFIA1_ENST00000530548.1_3'UTR|AP000487.5_ENST00000530690.1_RNA|PPFIA1_ENST00000389547.3_Missense_Mutation_p.P1177S	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	1177					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CTCTATGCAGCCAAAGAAGAT	0.478000													36	50					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171083269	171083269	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:171083269C>T	ENST00000367755.4	+	7	1061	c.950C>T	c.(949-951)aCc>aTc	p.T317I	FMO3_ENST00000538429.1_Missense_Mutation_p.T254I|FMO3_ENST00000542847.1_Missense_Mutation_p.T297I|FMO3_ENST00000392085.2_Missense_Mutation_p.T317I	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	317					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GAGGATGGGACCATATTTGAG	0.443000													32	35					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95511667	95511667	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:95511667C>T	ENST00000297591.5	-	17	4240	c.4165G>A	c.(4165-4167)Gac>Aac	p.D1389N	KIAA1429_ENST00000437199.1_Intron	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1389					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TCTCCTGTGTCCTTACTAAAT	0.318000													16	33					0	0	1	0	0
PPP6R3	55291	broad.mit.edu	37	11	68321647	68321647	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:68321647T>A	ENST00000393799.2	+	7	920	c.653T>A	c.(652-654)aTt>aAt	p.I218N	PPP6R3_ENST00000534534.1_Intron|PPP6R3_ENST00000265637.4_Missense_Mutation_p.I218N|PPP6R3_ENST00000529710.1_Missense_Mutation_p.I218N|PPP6R3_ENST00000527403.2_Missense_Mutation_p.I218N|PPP6R3_ENST00000524904.1_Missense_Mutation_p.I218N|PPP6R3_ENST00000524845.1_Missense_Mutation_p.I218N|PPP6R3_ENST00000393800.2_Missense_Mutation_p.I218N|PPP6R3_ENST00000393801.3_Missense_Mutation_p.I218N|PPP6R3_ENST00000265636.5_Missense_Mutation_p.I218N			Q5H9R7	PP6R3_HUMAN	protein phosphatase 6, regulatory subunit 3	218					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(10)|liver(2)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						CTTTGTGAAATTGTTCGCCTG	0.348000													37	36					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55043454	55043454	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:55043454C>T	ENST00000474759.1	+	34	2907	c.2859C>T	c.(2857-2859)tcC>tcT	p.S953S	CACNA2D3_ENST00000415676.2_Silent_p.S953S|CACNA2D3_ENST00000490478.1_Silent_p.S859S|CACNA2D3_ENST00000478261.1_3'UTR|CACNA2D3_ENST00000288197.5_Silent_p.S953S	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	953						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GGTGGCACTCCGATATGACAG	0.493000													19	24					0	0	1	0	0
ARL11	115761	broad.mit.edu	37	13	50204683	50204683	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:50204683G>A	ENST00000282026.1	+	2	435	c.100G>A	c.(100-102)Ggc>Agc	p.G34S	ARL11_ENST00000490932.1_Intron	NM_138450.5	NP_612459.1	Q969Q4	ARL11_HUMAN	ADP-ribosylation factor-like 11	34					small GTPase mediated signal transduction	intracellular	GTP binding|protein binding			kidney(1)|large_intestine(4)|ovary(1)	6		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.119)|Kidney(9;0.169)	GBM - Glioblastoma multiforme(99;1.67e-09)		CAAGCTGAAGGGCCACCAGCT	0.602000													50	86					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92600370	92600370	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:92600370C>T	ENST00000298047.6	+	21	12139	c.12122C>T	c.(12121-12123)tCg>tTg	p.S4041L	FAT3_ENST00000525166.1_Missense_Mutation_p.S3891L|FAT3_ENST00000409404.2_Missense_Mutation_p.S4041L|FAT3_ENST00000533797.1_Missense_Mutation_p.S376L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4041	EGF-like 2.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGCCTGCCATCGGGGGGTGAG	0.672000										TCGA Ovarian(4;0.039)			3	7					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43047117	43047117	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:43047117A>G	ENST00000428554.2	+	15	2295	c.1152A>G	c.(1150-1152)gaA>gaG	p.E384E	CCDC30_ENST00000340612.4_Silent_p.E384E|CCDC30_ENST00000390640.4_Silent_p.E173E|CCDC30_ENST00000342022.4_Silent_p.E384E|CCDC30_ENST00000507855.1_Silent_p.E173E			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	384										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						AGCTAGAGGAAAAGATAAAAG	0.383000													29	42					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68992704	68992704	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:68992704G>A	ENST00000288368.4	+	16	1946	c.1669G>A	c.(1669-1671)Gaa>Aaa	p.E557K	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	557	DEP 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						ATTCAAAGATGAACCCCTACT	0.328000													35	61					0	0	1	0	0
PPIC	5480	broad.mit.edu	37	5	122361498	122361498	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:122361498C>T	ENST00000306442.4	-	4	606	c.491G>A	c.(490-492)gGa>gAa	p.G164E		NM_000943.4	NP_000934.1	P45877	PPIC_HUMAN	peptidylprolyl isomerase C (cyclophilin C)	164	PPIase cyclophilin-type.				protein folding|signal transduction	cytoplasm	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	6		all_cancers(142;0.0168)|Prostate(80;0.0322)|Lung NSC(810;0.102)|all_lung(232;0.163)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000331)|Epithelial(69;0.000553)|all cancers(49;0.00505)	L-Proline(DB00172)	AATGACTTTTCCAAACACCAC	0.393000													31	26					0	0	1	0	0
HRG	3273	broad.mit.edu	37	3	186395101	186395101	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:186395101G>A	ENST00000232003.4	+	7	1087	c.1007G>A	c.(1006-1008)gGg>gAg	p.G336E		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	336					fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		GGCACAAATGGGGCCCAAAGA	0.498000													31	50					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32513747	32513747	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:32513747G>A	ENST00000286827.3	-	22	4022	c.3551C>T	c.(3550-3552)tCg>tTg	p.S1184L	TIAM1_ENST00000541036.1_Missense_Mutation_p.S1124L	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1184	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GATGAGGTACGACTCCAGCGT	0.567000													94	24					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64673805	64673805	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:64673805C>T	ENST00000421419.2	-	21	3298		c.e21+1		ATG2A_ENST00000377264.3_Splice_Site			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A								protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						CAAGCCCATACCTTCACATTC	0.697000													43	72					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150324824	150324824	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:150324824C>T	ENST00000328902.5	-	3	1078	c.862G>A	c.(862-864)Ggg>Agg	p.G288R	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	288							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCAGCCTTCCCCAGCAGGCAT	0.587000													51	60					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149501461	149501461	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:149501461C>T	ENST00000261799.4	-	16	2795	c.2326G>A	c.(2326-2328)Gat>Aat	p.D776N		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	776	Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	ACGTAGTTATCGTAAGGGGCC	0.517000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								25	65					0	0	1	0	0
SHQ1	55164	broad.mit.edu	37	3	72799677	72799677	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:72799677C>T	ENST00000325599.8	-	11	1631	c.1492G>A	c.(1492-1494)Gaa>Aaa	p.E498K	SHQ1_ENST00000468371.1_5'UTR|SHQ1_ENST00000463369.1_Missense_Mutation_p.E470K	NM_018130.2	NP_060600.2	Q6PI26	SHQ1_HUMAN	SHQ1, H/ACA ribonucleoprotein assembly factor	498					ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		GCACTGCTTTCTTCAAGAAAG	0.478000													56	78					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107415299	107415299	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:107415299G>A	ENST00000340010.5	-	16	1880	c.1696C>T	c.(1696-1698)Cga>Tga	p.R566*	SLC26A3_ENST00000422236.2_Nonsense_Mutation_p.R531*	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	566	STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						CGTAGAATTCGAAGTGGACTA	0.398000													46	69					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29599894	29599894	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:29599894C>T	ENST00000431530.3	+	1	1147	c.1089C>T	c.(1087-1089)caC>caT	p.H363H		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	353						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GGGAAGCACACCCGGAAGCCA	0.567000													41	10					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85707259	85707259	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:85707259G>A	ENST00000322366.6	-	24	4342	c.3935C>T	c.(3934-3936)tCc>tTc	p.S1312F	WDFY3_ENST00000295888.4_Missense_Mutation_p.S1312F			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1312						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TGACACAGGGGATGGCACCAC	0.388000													46	47					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25023485	25023485	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:25023485C>T	ENST00000400382.1	+	12	1862	c.1107C>T	c.(1105-1107)taC>taT	p.Y369Y	GGT1_ENST00000406383.2_Silent_p.Y369Y|GGT1_ENST00000404920.1_Silent_p.Y25Y|GGT1_ENST00000403838.1_Silent_p.Y25Y|GGT1_ENST00000401885.1_Silent_p.Y25Y|GGT1_ENST00000466310.1_3'UTR|GGT1_ENST00000400383.1_Silent_p.Y369Y|GGT1_ENST00000404532.1_Silent_p.Y25Y|GGT1_ENST00000248923.4_Silent_p.Y369Y|GGT1_ENST00000400380.1_Silent_p.Y369Y|GGT1_ENST00000404223.1_Silent_p.Y25Y			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	369					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding			breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	TCTCCTACTACAAGCCCGAGT	0.627000													40	56					0	0	1	0	0
EFHB	151651	broad.mit.edu	37	3	19924107	19924107	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:19924107G>A	ENST00000295824.9	-	12	2424	c.2263C>T	c.(2263-2265)Cct>Tct	p.P755S	EFHB_ENST00000344838.4_Missense_Mutation_p.P625S	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	755					signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						AAAATGGTAGGATATAGTAGT	0.393000													9	15					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50350844	50350844	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:50350844G>A	ENST00000376020.2	-	6	3323	c.3298C>T	c.(3298-3300)Cct>Tct	p.P1100S	SHROOM4_ENST00000289292.7_Missense_Mutation_p.P1100S|SHROOM4_ENST00000460112.3_Missense_Mutation_p.P984S	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1100	Poly-Pro.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					CGAGGAGGAGGAAAGGCCTTC	0.602000													34	4					0	0	1	0	0
OR6B3	150681	broad.mit.edu	37	2	240984558	240984558	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:240984558G>A	ENST00000319423.4	-	1	931	c.932C>T	c.(931-933)gCc>gTc	p.A311V		NM_173351.1	NP_775486.1	Q8NGW1	OR6B3_HUMAN	olfactory receptor, family 6, subfamily B, member 3	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(10)|lung(4)|ovary(2)|prostate(1)	18		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;1.05e-29)|all cancers(36;3.52e-28)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		CCCCTCTACGGCGCAGCTCGT	0.468000													172	90					0	0	1	0	0
PLS1	5357	broad.mit.edu	37	3	142413348	142413348	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:142413348G>A	ENST00000337777.3	+	11	1428	c.1215G>A	c.(1213-1215)atG>atA	p.M405I	PLS1_ENST00000497002.1_Missense_Mutation_p.M405I|PLS1_ENST00000457734.2_Missense_Mutation_p.M405I	NM_002670.2	NP_002661.2	Q14651	PLSI_HUMAN	plastin 1	405	Actin-binding 2.|CH 3.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	27						GGAACTGGATGAATTCCTTGG	0.393000													29	51					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23825131	23825131	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:23825131G>A	ENST00000354639.3	+	18	2578	c.2114G>A	c.(2113-2115)cGa>cAa	p.R705Q	STK31_ENST00000428484.1_Missense_Mutation_p.R705Q|STK31_ENST00000433467.2_Missense_Mutation_p.R728Q|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000355870.3_Missense_Mutation_p.R728Q	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	728							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						AGCTTGGAACGAGATCTTCTT	0.403000													66	76					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80735823	80735823	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:80735823G>A	ENST00000458043.2	+	43	5125	c.5119G>A	c.(5119-5121)Gaa>Aaa	p.E1707K	OTOGL_ENST00000547103.1_Missense_Mutation_p.E1695K	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TGAGAGCTGGGAAATTGAGAA	0.333000													10	8					0	0	1	0	0
ENO1	2023	broad.mit.edu	37	1	8926471	8926471	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:8926471G>A	ENST00000234590.4	-	7	653	c.534C>T	c.(532-534)ttC>ttT	p.F178F		NM_001428.3	NP_001419.1	P06733	ENOA_HUMAN	enolase 1, (alpha)	178	Required for repression of c-myc promoter activity.				gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity	p.F178F(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		TGGCTTCCCTGAAGTTTGCTG	0.527000													80	92					0	0	1	0	0
RPL13AP3	645683	broad.mit.edu	37	14	56233096	56233096	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:56233096C>T	ENST00000554458.1	+	0	75				RPL13AP3_ENST00000494676.1_RNA																							CAACCCTTTTCGAAGCGCCTA	0.572000													16	3					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586059	20586059	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:20586059C>T	ENST00000315543.4	+	1	494	c.494C>T	c.(493-495)aCc>aTc	p.T165I		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CACTACATGACCATCATGAAC	0.453000													52	33					0	0	1	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27766345	27766345	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:27766345G>A	ENST00000451261.2	+	5	1732	c.1333G>A	c.(1333-1335)Gat>Aat	p.D445N		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						CAATGATGACGATATTTACCT	0.423000													28	5					0	0	1	0	0
MYCN	4613	broad.mit.edu	37	2	16085834	16085834	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:16085834C>T	ENST00000281043.3	+	3	1307	c.1010C>T	c.(1009-1011)cCc>cTc	p.P337L		NM_005378.4	NP_005369.2	P04198	MYCN_HUMAN	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog	337					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	31	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			GCCCCCTCTCCCTACGTGGAG	0.602000			A		neuroblastoma								22	35					0	0	1	0	0
CDC7	8317	broad.mit.edu	37	1	91979528	91979528	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:91979528C>T	ENST00000428239.1	+	8	1105	c.846C>T	c.(844-846)gtC>gtT	p.V282V	CDC7_ENST00000234626.6_Silent_p.V282V|CDC7_ENST00000430031.2_Silent_p.V254V	NM_001134420.1	NP_001127892.1	O00311	CDC7_HUMAN	cell division cycle 7	282	Protein kinase.				cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|stomach(2)	23		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		GCCTTTCTGTCCAGCGCTCTG	0.388000													25	40					0	0	1	0	0
NRSN1	140767	broad.mit.edu	37	6	24145856	24145856	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:24145856C>T	ENST00000378491.4	+	4	571	c.270C>T	c.(268-270)atC>atT	p.I90I		NM_080723.4	NP_542454.3	Q8IZ57	NRSN1_HUMAN	neurensin 1	90					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle				breast(1)|endometrium(2)|large_intestine(2)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	22						CCCCCAAAATCGAAGCATTTG	0.488000													54	76					0	0	1	0	0
DEF6	50619	broad.mit.edu	37	6	35280512	35280512	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:35280512G>A	ENST00000316637.5	+	5	775	c.770G>A	c.(769-771)aGg>aAg	p.R257K	DEF6_ENST00000542066.1_Intron	NM_022047.3	NP_071330.3	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog (mouse)	257	PH.					cytoplasm|nucleus|plasma membrane				cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	15						AAAGAGAAAAGGGGCATTATC	0.602000													3	26					0	0	1	0	0
FSCN3	29999	broad.mit.edu	37	7	127239446	127239446	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:127239446G>A	ENST00000265825.5	+	5	1351	c.1132G>A	c.(1132-1134)Gaa>Aaa	p.E378K	FSCN3_ENST00000420086.2_Missense_Mutation_p.E244K	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	378						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						CCCAAATGAGGAATTTGGGAT	0.498000													43	61					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106116852	106116852	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:106116852C>T	ENST00000357242.5	+	21	3194	c.3020C>T	c.(3019-3021)cCt>cTt	p.P1007L	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.P1001L	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	1007						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CATGAGGACCCTGAAGAAGAA	0.373000													45	1					0	0	1	0	0
ICK	22858	broad.mit.edu	37	6	52876952	52876952	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:52876952G>A	ENST00000356971.3	-	11	1715	c.1226C>T	c.(1225-1227)tCc>tTc	p.S409F	ICK_ENST00000350082.5_Missense_Mutation_p.S409F	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	409					intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					TGTTGACCTGGAAATAAGACC	0.453000													35	48					0	0	1	0	0
TRAV2	28691	broad.mit.edu	37	14	22180973	22180973	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:22180973G>A	ENST00000390424.2	+	0	255																											CAGCAGGGACGATACAACATG	0.512000													38	101					0	0	1	0	0
C14orf105	55195	broad.mit.edu	37	14	57949829	57949829	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:57949829C>T	ENST00000216445.3	-	3	483	c.347G>A	c.(346-348)gGa>gAa	p.G116E	C14orf105_ENST00000422976.2_Missense_Mutation_p.G116E|C14orf105_ENST00000534126.1_Missense_Mutation_p.G116E|C14orf105_ENST00000526336.1_3'UTR	NM_018168.2	NP_060638.2	Q9NVL8	CN105_HUMAN	chromosome 14 open reading frame 105	116										breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)	11						CAGGAGTCTTCCTGAAGTAAT	0.502000													37	4					0	0	1	0	0
LARS2	23395	broad.mit.edu	37	3	45557692	45557692	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:45557692G>A	ENST00000415258.1	+	16	2109	c.1968G>A	c.(1966-1968)caG>caA	p.Q656Q	LARS2_ENST00000467936.1_3'UTR|LARS2_ENST00000414984.1_Silent_p.Q613Q|LARS2_ENST00000265537.3_Silent_p.Q656Q			Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	656					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	TTGTGGAGCAGTATGGGATCG	0.483000													50	59					0	0	1	0	0
GPR39	2863	broad.mit.edu	37	2	133402744	133402744	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:133402744A>G	ENST00000329321.3	+	2	1396	c.927A>G	c.(925-927)aaA>aaG	p.K309K	LYPD1_ENST00000397463.2_3'UTR|GPR39_ENST00000470071.1_3'UTR	NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	309						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CTGCGGCCAAACCCAAGCACG	0.582000													40	41					0	0	1	0	0
DUXA	503835	broad.mit.edu	37	19	57670611	57670611	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:57670611G>A	ENST00000554048.2	-	3	215	c.216C>T	c.(214-216)ttC>ttT	p.F72F		NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A	72						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		GTCTTTTCTGGAATCCGTGCC	0.418000													49	65					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91804391	91804391	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:91804391C>T	ENST00000389857.6	-	10	1094	c.1008G>A	c.(1006-1008)aaG>aaA	p.K336K		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	336					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				GCAGCTTCTCCTTGCAGCGGG	0.632000													30	29					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	31023498	31023498	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:31023498G>A	ENST00000399914.1	-	6	1415	c.894C>T	c.(892-894)tcC>tcT	p.S298S	GRIK1_ENST00000389125.3_Silent_p.S298S|GRIK1_ENST00000399907.1_Silent_p.S298S|GRIK1_ENST00000389124.2_Silent_p.S298S|GRIK1_ENST00000399913.1_Silent_p.S298S|GRIK1_ENST00000309434.7_Silent_p.S298S|GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000535441.1_Silent_p.S298S|GRIK1_ENST00000327783.4_Silent_p.S298S|GRIK1_ENST00000399909.1_Silent_p.S298S			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	298					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GTCTCTCCATGGACCACTTCT	0.468000													68	8					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170965688	170965688	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:170965688G>A	ENST00000367759.4	+	14	1532	c.1378G>A	c.(1378-1380)Gga>Aga	p.G460R	MROH9_ENST00000367758.3_Missense_Mutation_p.G460R	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		GAATTGTTCTGGACTGCAACA	0.413000													39	74					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101818765	101818765	+	Missense_Mutation	SNP	C	C	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:101818765C>G	ENST00000263468.8	+	4	668	c.398C>G	c.(397-399)tCc>tGc	p.S133C		NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	133							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TCTTTAGTTTCCCGAAAACCA	0.333000													27	33					0	0	1	0	0
OR4K15	81127	broad.mit.edu	37	14	20443711	20443711	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:20443711C>T	ENST00000305051.5	+	1	109	c.34C>T	c.(34-36)Cct>Tct	p.P12S		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGTTTCTCTCCTATTCAGGT	0.378000													19	38					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212495235	212495235	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:212495235C>T	ENST00000342788.4	-	17	2341	c.2031G>A	c.(2029-2031)agG>agA	p.R677R	ERBB4_ENST00000402597.1_Silent_p.R667R|ERBB4_ENST00000436443.1_Silent_p.R677R	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	677					cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TGATGCTCTTCCTTCTAACAT	0.418000										TSP Lung(8;0.080)			91	56					0	0	1	0	0
SLC9A5	6553	broad.mit.edu	37	16	67289320	67289320	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:67289320T>C	ENST00000299798.11	+	4	744	c.679T>C	c.(679-681)Ttt>Ctt	p.F227L	SLC9A5_ENST00000561472.2_3'UTR	NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	227					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CTGCAACTCCTTTGTGGAGAT	0.597000													63	68					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30680705	30680705	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:30680705G>A	ENST00000376406.3	-	5	1661	c.1014C>T	c.(1012-1014)atC>atT	p.I338I	MDC1-AS1_ENST00000442150.1_RNA|MDC1_ENST00000376405.2_Silent_p.I338I	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	338	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						GGGTTGCTGGGATCCTCTCTT	0.552000								Other conserved DNA damage response genes					67	87					0	0	1	0	0
JPH4	84502	broad.mit.edu	37	14	24040407	24040407	+	Silent	SNP	G	G	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:24040407G>C	ENST00000397118.3	-	6	2435	c.1533C>G	c.(1531-1533)ggC>ggG	p.G511G	JPH4_ENST00000544177.1_Silent_p.G176G|JPH4_ENST00000356300.4_Silent_p.G511G	NM_032452.2	NP_115828.2	Q96JJ6	JPH4_HUMAN	junctophilin 4	511					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				endometrium(1)|large_intestine(2)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		CAGCCTCATAGCCAGCTAGTT	0.657000													160	103					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123848276	123848276	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:123848276G>A	ENST00000531945.1	-	1	212	c.123C>T	c.(121-123)ttC>ttT	p.F41F		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGAAGAGGAGGAAGAAGAGGC	0.517000													30	26					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227895221	227895221	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:227895221C>T	ENST00000396625.3	-	41	4118	c.3911G>A	c.(3910-3912)gGc>gAc	p.G1304D	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1304D	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1304	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GCCTGGTGGGCCAGGGGGACC	0.552000													25	113					0	0	1	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27766047	27766047	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:27766047C>T	ENST00000451261.2	+	5	1434	c.1035C>T	c.(1033-1035)acC>acT	p.T345T		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						TTGTCTTCACCATTGACCTCA	0.478000													19	5					0	0	1	0	0
PRRT3	285368	broad.mit.edu	37	3	9991428	9991428	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:9991428G>A	ENST00000412055.1	-	2	501	c.372C>T	c.(370-372)tcC>tcT	p.S124S	PRRT3-AS1_ENST00000431558.1_RNA|PRRT3_ENST00000411976.2_Silent_p.S124S	NM_207351.3	NP_997234.3	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3	124						integral to membrane				NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)|stomach(2)	13						TCCAGCCGTGGGAGCTTGGTC	0.592000													51	76					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179650466	179650466	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179650466T>C	ENST00000589042.1	-	15	2598	c.2374A>G	c.(2374-2376)Aag>Gag	p.K792E	TTN_ENST00000591111.1_Missense_Mutation_p.K792E|TTN_ENST00000359218.5_Missense_Mutation_p.K746E|TTN_ENST00000342992.6_Missense_Mutation_p.K792E|TTN_ENST00000460472.2_Missense_Mutation_p.K746E|TTN_ENST00000342175.6_Missense_Mutation_p.K746E|TTN_ENST00000360870.5_Missense_Mutation_p.K792E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	792							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTAGTTTTCTTGATCTGCATT	0.413000													67	46					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072794	17072794	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:17072794G>A	ENST00000359963.3	-	1	906	c.647C>T	c.(646-648)tCc>tTc	p.S216F		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	216					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GAGGAGGCAGGAATCCTCCAG	0.612000													140	67					0	0	1	0	0
GPR180	160897	broad.mit.edu	37	13	95264488	95264488	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:95264488C>T	ENST00000376958.4	+	3	374	c.349C>T	c.(349-351)Ccg>Tcg	p.P117S		NM_180989.5	NP_851320.1	Q86V85	GP180_HUMAN	G protein-coupled receptor 180	117						integral to membrane				breast(1)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	10	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					GTCCCAGATTCCGTCTCCACA	0.393000													85	130					0	0	1	0	0
F2	2147	broad.mit.edu	37	11	46747708	46747708	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:46747708G>A	ENST00000311907.5	+	7	915	c.859G>A	c.(859-861)Gac>Aac	p.D287N	F2_ENST00000530231.1_Missense_Mutation_p.D287N	NM_000506.3	NP_000497.1	P00734	THRB_HUMAN	coagulation factor II (thrombin)	287	Kringle 2.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	27		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	TGGGTACTGCGACCTCAACTA	0.582000													62	9					0	0	1	0	0
NUDT16L1	84309	broad.mit.edu	37	16	4743802	4743802	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:4743802C>T	ENST00000405142.1	+	1	84	c.75C>T	c.(73-75)agC>agT	p.S25S	NUDT16L1_ENST00000304301.6_Silent_p.S25S|NUDT16L1_ENST00000586536.1_Silent_p.S25S|NUDT16L1_ENST00000586252.1_Silent_p.S25S			Q9BRJ7	SDOS_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1	25						cytoplasm	hydrolase activity			endometrium(1)|large_intestine(1)|lung(1)|skin(1)	4						CGGGCTGGAGCCACTCGTGCC	0.716000													4	7					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86469000	86469000	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:86469000G>A	ENST00000361669.2	+	4	3269	c.2170G>A	c.(2170-2172)Gaa>Aaa	p.E724K	GRM3_ENST00000546348.1_Missense_Mutation_p.E316K|GRM3_ENST00000536043.1_Missense_Mutation_p.E596K|GRM3_ENST00000394720.2_Intron|GRM3_ENST00000439827.1_Intron	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	724					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AGAGAAGCGGGAAACAGTCAT	0.498000													24	31					0	0	1	0	0
CCDC110	256309	broad.mit.edu	37	4	186379979	186379979	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:186379979A>G	ENST00000307588.3	-	6	1837	c.1762T>C	c.(1762-1764)Tta>Cta	p.L588L	CCDC110_ENST00000393540.3_Silent_p.L551L|CCDC110_ENST00000510617.1_Silent_p.L588L	NM_152775.3	NP_689988.1	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110	588						nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(9)	30		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TTTTTCTCTAACATTTCTTTT	0.308000													31	41					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151171382	151171382	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:151171382G>A	ENST00000282466.3	-	3	504	c.505C>T	c.(505-507)Cac>Tac	p.H169Y		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	169					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTATCTGGGTGGAGCTTAGTG	0.418000													47	55					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36229804	36229804	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:36229804C>T	ENST00000400445.3	+	54	8751	c.8217C>T	c.(8215-8217)atC>atT	p.I2739I	NBEA_ENST00000379922.3_Silent_p.I317I|NBEA_ENST00000310336.4_Silent_p.I2739I|NBEA_ENST00000537702.1_Silent_p.I532I|NBEA_ENST00000379939.2_Silent_p.I2736I|NBEA_ENST00000540320.1_Silent_p.I2739I	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	2739						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ACTGCTACATCGTGTCCGGAT	0.512000													49	167					0	0	1	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338663	13338663	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:13338663G>A	ENST00000602906.1	+	0	451																				kidney(3)|lung(1)	4						CCTTAAAGAAGATCAGACAGA	0.488000													25	30					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20037429	20037429	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:20037429C>T	ENST00000245957.5	+	2	208	c.132C>T	c.(130-132)atC>atT	p.I44I	C20orf26_ENST00000377306.1_Silent_p.I44I|C20orf26_ENST00000451767.2_Silent_p.I44I|C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000389656.3_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	44										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		AGCTAAATATCATCTATCTTC	0.368000													48	76					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141736713	141736713	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:141736713C>T	ENST00000475668.2	+	18	2221	c.2167C>T	c.(2167-2169)Cta>Tta	p.L723L	MGAM_ENST00000549489.2_Silent_p.L723L			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	723	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ATTGCCCTACCTATACACCCT	0.512000													115	155					0	0	1	0	0
ELF4	2000	broad.mit.edu	37	X	129201425	129201425	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:129201425C>T	ENST00000308167.5	-	9	1642	c.1263G>A	c.(1261-1263)acG>acA	p.T421T	ELF4_ENST00000335997.7_Silent_p.T421T	NM_001421.3	NP_001412.1	Q99607	ELF4_HUMAN	E74-like factor 4 (ets domain transcription factor)	421					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	22						TCAGTGGGATCGTCTGCAGGG	0.592000			T	ERG	AML								55	4					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55027362	55027362	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:55027362C>T	ENST00000371336.3	+	5	1331	c.1130C>T	c.(1129-1131)gCg>gTg	p.A377V	CASS4_ENST00000360314.3_Missense_Mutation_p.A377V|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	377	Ser-rich.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						GAGAATTCCGCGGGCCATAAT	0.502000													30	35					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19483499	19483499	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:19483499C>T	ENST00000507958.1	-	14	2783	c.1793G>A	c.(1792-1794)cGg>cAg	p.R598Q	CDH18_ENST00000502796.1_Missense_Mutation_p.G562R|CDH18_ENST00000382275.1_Missense_Mutation_p.R598Q|CDH18_ENST00000274170.4_Missense_Mutation_p.R598Q|CDH18_ENST00000506372.1_Missense_Mutation_p.G563R			Q13634	CAD18_HUMAN	cadherin 18, type 2	598	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					ATGGCAGGTCCGCACACGCCC	0.527000													17	2					0	0	1	0	0
NIPAL4	348938	broad.mit.edu	37	5	156898686	156898686	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:156898686C>T	ENST00000311946.7	+	5	749	c.633C>T	c.(631-633)ttC>ttT	p.F211F	ADAM19_ENST00000430702.2_Intron|NIPAL4_ENST00000435489.2_Silent_p.F192F	NM_001099287.1	NP_001092757.1	Q0D2K0	NIPA4_HUMAN	NIPA-like domain containing 4	211						integral to membrane	receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|prostate(1)|skin(1)	22						CCTCATATTTCCTGAGGGAGA	0.547000											OREG0016979	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	8					0	0	1	0	0
CRMP1	1400	broad.mit.edu	37	4	5868433	5868433	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:5868433G>A	ENST00000324989.7	-	2	520	c.432C>T	c.(430-432)tcC>tcT	p.S144S	CRMP1_ENST00000397890.2_Silent_p.S30S|CRMP1_ENST00000511535.1_5'UTR|CRMP1_ENST00000512574.1_Silent_p.S28S	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	30					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		CAGCATAAAGGGATTGGTCAT	0.478000													38	61					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154393573	154393573	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:154393573G>A	ENST00000435029.4	+	1	314	c.154G>A	c.(154-156)Gat>Aat	p.D52N		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	52	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CTTCACCTACGATTTTGTGTT	0.483000													36	18					0	0	1	0	0
SDR16C5	195814	broad.mit.edu	37	8	57228786	57228786	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:57228786C>T	ENST00000396721.2	-	2	251	c.121G>A	c.(121-123)Gaa>Aaa	p.E41K	SDR16C5_ENST00000522671.1_Missense_Mutation_p.E41K|SDR16C5_ENST00000303749.3_Missense_Mutation_p.E41K			Q8N3Y7	RDHE2_HUMAN	short chain dehydrogenase/reductase family 16C, member 5	41					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)	16						AGGACTATTTCACCAGCAACG	0.448000													48	79					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83065753	83065753	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:83065753G>A	ENST00000566620.1	+	3	586	c.296G>A	c.(295-297)cGg>cAg	p.R99Q	CDH13_ENST00000268613.10_Missense_Mutation_p.R146Q|CDH13_ENST00000446376.2_Missense_Mutation_p.R99Q|CDH13_ENST00000431540.3_Missense_Mutation_p.R99Q|CDH13_ENST00000428848.3_Missense_Mutation_p.R99Q|CDH13_ENST00000569454.1_3'UTR|CDH13_ENST00000565636.1_Missense_Mutation_p.R99Q	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	99					adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		GTCCATGCACGGACCCCCCAT	0.512000													11	15					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	172357894	172357894	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:172357894G>A	ENST00000358155.4	+	20	2643	c.2467G>A	c.(2467-2469)Gga>Aga	p.G823R	DNM3_ENST00000367731.1_Missense_Mutation_p.G819R|DNM3_ENST00000355305.5_Missense_Mutation_p.G829R	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	829					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TGACTCCTTCGGAGCCCCTCC	0.622000													10	16					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20482414	20482414	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:20482414C>T	ENST00000573854.1	+	5	730	c.616C>T	c.(616-618)Cac>Tac	p.H206Y	ACSM2A_ENST00000396104.2_Missense_Mutation_p.H206Y|ACSM2A_ENST00000417235.2_Missense_Mutation_p.H127Y|ACSM2A_ENST00000536134.1_Silent_p.I7I|ACSM2A_ENST00000575690.1_Missense_Mutation_p.H206Y|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000219054.6_Missense_Mutation_p.H206Y	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	206					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						CACCACTCATCACTGTGTGGA	0.507000													52	41					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	84028139	84028139	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:84028139C>T	ENST00000280241.8	-	1	49	c.50G>A	c.(49-51)gGg>gAg	p.G17E	DLG2_ENST00000543673.1_Intron|DLG2_ENST00000398309.2_Intron|DLG2_ENST00000532653.1_Intron|DLG2_ENST00000524982.1_Intron|DLG2_ENST00000376104.2_Intron|DLG2_ENST00000398301.2_Missense_Mutation_p.G17E	NM_001206769.1	NP_001193698.1	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	0						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GGCATCCATCCCATCGGACCC	0.572000													89	110					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453137	140453137	+	Missense_Mutation	SNP	C	C	T	rs121913227		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:140453137C>T	ENST00000288602.6	-	15	1858	c.1798G>A	c.(1798-1800)Gtg>Atg	p.V600M		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600K(252)|p.V600R(44)|p.V600M(21)|p.V600L(9)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600Q(2)|p.T599_V600insT(2)|p.T599_V600insTT(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	CGAGATTTCACTGTAGCTAGA	0.363000	V600M(IGR1_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				37	45					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179441841	179441841	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179441841G>A	ENST00000589042.1	-	324	69445	c.69221C>T	c.(69220-69222)tCc>tTc	p.S23074F	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.S21433F|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|RP11-171I2.5_ENST00000604215.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S14134F|TTN_ENST00000342992.6_Missense_Mutation_p.S20506F|TTN_ENST00000460472.2_Missense_Mutation_p.S14009F|TTN_ENST00000342175.6_Missense_Mutation_p.S14201F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21433			P -> L.				ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGTATATAGGACTTAATTGG	0.453000													35	96					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87674195	87674195	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:87674195C>T	ENST00000436978.1	+	20	3680	c.3200C>T	c.(3199-3201)tCc>tTc	p.S1067F	PTPN13_ENST00000316707.6_Intron|PTPN13_ENST00000427191.2_Intron|PTPN13_ENST00000411767.2_Missense_Mutation_p.S1067F|PTPN13_ENST00000511467.1_Missense_Mutation_p.S1067F	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	1067						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AACTCTTCATCCCAAGTACCC	0.348000													17	18					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96827158	96827158	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:96827158G>A	ENST00000539050.1	-	2	591	c.30C>T	c.(28-30)ttC>ttT	p.F10F	CYP2C8_ENST00000535898.1_Intron|CYP2C8_ENST00000371270.3_Intron			P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	169					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	CACAGCCAAGGAAGAAAGTGC	0.478000													26	8					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56094762	56094762	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:56094762G>A	ENST00000257880.7	-	4	810	c.591C>T	c.(589-591)tgC>tgT	p.C197C	ITGA7_ENST00000257879.6_Silent_p.C197C|ITGA7_ENST00000394229.2_Silent_p.C197C|ITGA7_ENST00000553804.1_Silent_p.C197C|ITGA7_ENST00000394230.2_Silent_p.C197C|ITGA7_ENST00000555728.1_Silent_p.C197C|ITGA7_ENST00000347027.6_Silent_p.C197C|ITGA7_ENST00000452168.2_Silent_p.C100C			Q13683	ITA7_HUMAN	integrin, alpha 7	197					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						TGCCCTGCTGGCAGAACCCAA	0.587000													18	21					0	0	1	0	0
ATP2B1	490	broad.mit.edu	37	12	89998001	89998001	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:89998001G>A	ENST00000428670.3	-	16	3021	c.2565C>T	c.(2563-2565)ttC>ttT	p.F855F	ATP2B1_ENST00000261173.2_Silent_p.F855F|ATP2B1_ENST00000359142.3_Silent_p.F855F|ATP2B1_ENST00000393164.2_Silent_p.F598F|ATP2B1_ENST00000348959.3_Silent_p.F855F			P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	855					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						GGAACTGAAGGAATTTTGAGA	0.383000													32	22					0	0	1	0	0
DTX3	196403	broad.mit.edu	37	12	58002893	58002893	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:58002893G>A	ENST00000548198.1	+	5	2506	c.1002G>A	c.(1000-1002)cgG>cgA	p.R334R	DTX3_ENST00000548804.1_Silent_p.R334R|DTX3_ENST00000337737.3_Silent_p.R334R|DTX3_ENST00000551632.1_Silent_p.R337R			Q8N9I9	DTX3_HUMAN	deltex homolog 3 (Drosophila)	334					Notch signaling pathway	cytoplasm	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)|urinary_tract(1)	12	Melanoma(17;0.122)					ACCTGACCCGGGTGCAAGAGG	0.547000													13	42					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52344001	52344001	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:52344001C>T	ENST00000354831.7	-	1	476	c.287G>A	c.(286-288)aGt>aAt	p.S96N	NRD1_ENST00000352171.7_Missense_Mutation_p.S96N|NRD1_ENST00000544028.1_Intron	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	96					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						CCCAGCATTACTGAGAGACCC	0.612000													34	51					0	0	1	0	0
PATZ1	23598	broad.mit.edu	37	22	31738942	31738942	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:31738942C>T	ENST00000266269.5	-	2	1905	c.1276G>A	c.(1276-1278)Gat>Aat	p.D426N	PATZ1_ENST00000351933.4_Missense_Mutation_p.D426N|PATZ1_ENST00000405309.3_Missense_Mutation_p.D426N|PATZ1_ENST00000215919.3_Missense_Mutation_p.D426N	NM_014323.2	NP_055138.2	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	426					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	12						TTCAAGTGATCAGGCCTGGAA	0.527000													38	121					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128320017	128320017	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:128320017G>A	ENST00000368227.3	-	17	2929	c.2563C>T	c.(2563-2565)Cgc>Tgc	p.R855C	PTPRK_ENST00000368215.3_Missense_Mutation_p.R842C|PTPRK_ENST00000368210.3_Missense_Mutation_p.R855C|PTPRK_ENST00000532331.1_Missense_Mutation_p.R859C|PTPRK_ENST00000368213.5_Missense_Mutation_p.R843C|PTPRK_ENST00000368226.4_Missense_Mutation_p.R843C|PTPRK_ENST00000368207.3_Missense_Mutation_p.R869C			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	842					cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TCTAGAAGGCGACTGGACTCT	0.448000													15	28					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141722156	141722156	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:141722156G>A	ENST00000475668.2	+	7	853	c.799G>A	c.(799-801)Gga>Aga	p.G267R	MGAM_ENST00000549489.2_Missense_Mutation_p.G267R			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	267	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity	p.G267*(4)		cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GTATGGCCTGGGAGAGCATGT	0.502000													61	53					0	0	1	0	0
IL17RE	132014	broad.mit.edu	37	3	9945716	9945716	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:9945716G>A	ENST00000454190.2	+	3	234	c.148_splice	c.e3-1	p.G50_splice	IL17RE_ENST00000295980.3_Splice_Site_p.G50_splice|IL17RE_ENST00000421412.1_Splice_Site_p.G83_splice|IL17RE_ENST00000383814.3_Splice_Site_p.G50_splice	NM_001193380.1	NP_001180309.1	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E	50						cytoplasm|extracellular region|integral to membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(11)|skin(1)	21				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		TCTTTCCCAGGAAGTTCTGCC	0.537000													102	124					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6265192	6265192	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:6265192G>A	ENST00000379936.2	+	6	1396	c.1281G>A	c.(1279-1281)ggG>ggA	p.G427G		NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	427					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACATGTCTGGGAACCGCCGCA	0.562000													29	41					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48311748	48311748	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:48311748G>A	ENST00000435803.1	+	17	2509	c.2485G>A	c.(2485-2487)Gaa>Aaa	p.E829K		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	829					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						AATACTTTTTGAAATTAATCC	0.318000													14	12					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48448477	48448477	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:48448477G>A	ENST00000358536.4	-	35	6378	c.6109C>T	c.(6109-6111)Ctg>Ttg	p.L2037L	PLXNB1_ENST00000456774.1_Silent_p.L1854L|PLXNB1_ENST00000448774.2_Silent_p.L648L|PLXNB1_ENST00000358459.4_Silent_p.L1854L|PLXNB1_ENST00000296440.6_Silent_p.L2037L	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	2037					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGTGCATACAGAAGTTTGTTG	0.572000													37	51					0	0	1	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44221313	44221313	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:44221313C>T	ENST00000371554.1	+	12	2367	c.2153C>T	c.(2152-2154)tCt>tTt	p.S718F	HSP90AB1_ENST00000371646.5_Missense_Mutation_p.S718F|HSP90AB1_ENST00000353801.3_Missense_Mutation_p.S718F			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	718					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GAGGATGCGTCTCGCATGGAA	0.512000											OREG0017471	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	80					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18573875	18573875	+	Splice_Site	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:18573875T>C	ENST00000433979.1	+	16	2309	c.2192_splice	c.e16-1	p.S731_splice	PIK3C2G_ENST00000266497.5_Splice_Site_p.S731_splice|PIK3C2G_ENST00000538779.1_Splice_Site_p.S772_splice	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	731					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				TGTGTATTAGTTTTCCAGATC	0.373000													33	30					0	0	1	0	0
CEP135	9662	broad.mit.edu	37	4	56890737	56890737	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:56890737C>T	ENST00000257287.4	+	25	3515	c.3391C>T	c.(3391-3393)Cct>Tct	p.P1131S		NM_025009.4	NP_079285.2	Q66GS9	CP135_HUMAN	centrosomal protein 135kDa	1131					centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(26)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	50	Glioma(25;0.08)|all_neural(26;0.101)					TCTGAGGTCTCCTTCACATTC	0.398000													109	155					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94707102	94707102	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:94707102C>T	ENST00000304338.3	+	9	1100	c.946C>T	c.(946-948)Cat>Tat	p.H316Y		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	316						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						TTTATCTTTCCATTTAGGAAA	0.289000													14	17					0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29910607	29910607	+	Silent	SNP	G	G	C	rs72555397		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:29910607G>C	ENST00000396634.1	+	4	488	c.147G>C	c.(145-147)gtG>gtC	p.V49V	HLA-A_ENST00000376802.2_Silent_p.V49V|HLA-A_ENST00000376806.5_Silent_p.V49V|HLA-A_ENST00000376809.5_Silent_p.V49V			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	49	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.V49V(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TCATCGCCGTGGGCTACGTGG	0.692000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			4	55					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138442555	138442555	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:138442555G>A	ENST00000344876.4	-	4	3422	c.3036C>T	c.(3034-3036)ttC>ttT	p.F1012F	PCDH18_ENST00000511115.1_Silent_p.F192F|PCDH18_ENST00000412923.2_Silent_p.F1011F|PCDH18_ENST00000510305.1_Silent_p.F223F|PCDH18_ENST00000507846.1_Silent_p.F791F	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	1012	Interaction with DAB1 (By similarity).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					AGAGACGCTGGAACACACTGC	0.532000													45	48					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24835075	24835075	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:24835075G>A	ENST00000376454.3	+	21	5684	c.5654G>A	c.(5653-5655)gGc>gAc	p.G1885D	KIAA1217_ENST00000376451.2_3'UTR|KIAA1217_ENST00000376452.3_Missense_Mutation_p.G1316D|KIAA1217_ENST00000376462.1_Missense_Mutation_p.G1206D|KIAA1217_ENST00000396445.1_3'UTR|KIAA1217_ENST00000458595.1_Missense_Mutation_p.G1291D	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	1885	Ser-rich.				embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						AGTCAAAATGGCCGAGCAccc	0.517000													46	12					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167217996	167217996	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:167217996C>T	ENST00000308378.3	-	14	2225	c.1920G>A	c.(1918-1920)agG>agA	p.R640R	WDR49_ENST00000476376.1_Silent_p.R465R|WDR49_ENST00000479765.1_Intron|WDR49_ENST00000453925.2_Silent_p.R605R	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	640										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CTGGTTCTTTCCTAAAGTATT	0.438000													118	134					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30701013	30701013	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:30701013C>T	ENST00000256246.2	-	1	5595	c.5521G>A	c.(5521-5523)Gac>Aac	p.D1841N		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1841										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTAGGAGAGTCCCCACATACA	0.358000													63	17					0	0	1	0	0
IFT43	112752	broad.mit.edu	37	14	76488722	76488722	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:76488722C>T	ENST00000556742.1	+	3	203	c.200C>T	c.(199-201)tCc>tTc	p.S67F	IFT43_ENST00000238628.6_Missense_Mutation_p.S67F|IFT43_ENST00000553338.1_3'UTR|IFT43_ENST00000314067.6_Missense_Mutation_p.S67F	NM_001255995.1	NP_001242924.1	Q96FT9	IFT43_HUMAN	intraflagellar transport 43 homolog (Chlamydomonas)	67					cilium morphogenesis|intraflagellar retrograde transport					endometrium(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						GCAGGTGATTCCGTGAAGGCT	0.478000													32	78					0	0	1	0	0
C17orf70	80233	broad.mit.edu	37	17	79514225	79514225	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:79514225G>A	ENST00000537152.1	-	5	1955	c.1430C>T	c.(1429-1431)cCc>cTc	p.P477L	C17orf70_ENST00000425898.2_Missense_Mutation_p.P277L|C17orf70_ENST00000327787.8_Missense_Mutation_p.P628L	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	628					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			GACGTCGGAGGGGCACTCATC	0.662000													55	56					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19856954	19856954	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:19856954C>T	ENST00000548109.1	+	0	72																											TAAACATGCTCCCTATTTCTG	0.383000													12	33					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207647184	207647184	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:207647184C>T	ENST00000367057.3	+	12	2383	c.2194C>T	c.(2194-2196)Cca>Tca	p.P732S	CR2_ENST00000458541.2_Missense_Mutation_p.P646S|CR2_ENST00000367059.3_Missense_Mutation_p.P673S|CR2_ENST00000367058.3_Missense_Mutation_p.P673S	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	794	Sushi 12.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TCAAGAACTTCCAGCTGGTTC	0.423000													53	75					0	0	1	0	0
KCTD12	115207	broad.mit.edu	37	13	77459429	77459429	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:77459429G>A	ENST00000377474.2	-	1	1096	c.855C>T	c.(853-855)tcC>tcT	p.S285S	KCTD12_ENST00000317765.2_Silent_p.S285S	NM_138444.3	NP_612453.1	Q96CX2	KCD12_HUMAN	potassium channel tetramerization domain containing 12	285						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			kidney(1)|large_intestine(1)|lung(1)|ovary(1)	4		Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.0499)		AGCCCGACTCGGACAGCTTGT	0.637000											OREG0022449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	7					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55418737	55418737	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:55418737C>T	ENST00000312422.2	+	1	358	c.358C>T	c.(358-360)Cgt>Tgt	p.R120C		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R120C(1)		endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				GGCCTATGATCGTTATGTGGC	0.428000													99	142					0	0	1	0	0
FOXI2	399823	broad.mit.edu	37	10	129536903	129536903	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:129536903A>G	ENST00000388920.4	+	2	670	c.631A>G	c.(631-633)Agc>Ggc	p.S211G		NM_207426.2	NP_997309.2	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	211					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|lung(3)	4		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				GGGAGCCAGGAGCGTGGGAGG	0.697000													5	1					0	0	1	0	0
RNF40	9810	broad.mit.edu	37	16	30774532	30774532	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:30774532C>T	ENST00000324685.6	+	3	661	c.226C>T	c.(226-228)Cga>Tga	p.R76*	RNF40_ENST00000563683.1_Nonsense_Mutation_p.R76*|RNF40_ENST00000357890.5_Nonsense_Mutation_p.R76*|RNF40_ENST00000402121.3_Nonsense_Mutation_p.R76*	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586.1	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	76					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			ACTCCGAGAACGAATTGAGAA	0.517000													29	44					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037210	75037210	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:75037210C>T	ENST00000326665.5	-	14	4402	c.4184G>A	c.(4183-4185)gGa>gAa	p.G1395E	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1395	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TGCTGTTTTTCCTACTAACTC	0.498000													62	80					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1994045	1994045	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:1994045G>A	ENST00000382722.5	-	11	1523	c.1161C>T	c.(1159-1161)ttC>ttT	p.F387F	CACNA2D4_ENST00000588077.1_Silent_p.F323F|CACNA2D4_ENST00000585732.1_Silent_p.F303F|CACNA2D4_ENST00000587995.1_Silent_p.F387F|CACNA2D4_ENST00000585708.1_Silent_p.F323F|CACNA2D4_ENST00000586184.1_Silent_p.F387F	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	387	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TGGCCTCTTGGAACTGTGTAG	0.612000													11	23					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48389734	48389734	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:48389734C>T	ENST00000224600.4	-	1	1257	c.1144G>A	c.(1144-1146)Gat>Aat	p.D382N		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	382	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	AGCCTGGGATCCTCAGACGCA	0.647000													26	9					0	0	1	0	0
LGI1	9211	broad.mit.edu	37	10	95518009	95518009	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:95518009A>G	ENST00000371418.4	+	1	368	c.108A>G	c.(106-108)aaA>aaG	p.K36K	LGI1_ENST00000478763.1_3'UTR|LGI1_ENST00000371413.3_Silent_p.K36K|LGI1_ENST00000542308.1_Silent_p.K36K	NM_005097.2	NP_005088.1	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1	36	LRRNT.				axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(18)|ovary(2)|skin(1)	29		Colorectal(252;0.124)				AGGGGAAGAAACCAGCGAAGC	0.453000													67	7					0	0	1	0	0
KAT5	10524	broad.mit.edu	37	11	65484175	65484175	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:65484175T>C	ENST00000341318.4	+	9	1301	c.1067T>C	c.(1066-1068)tTc>tCc	p.F356S	KAT5_ENST00000530446.1_Missense_Mutation_p.F304S|KAT5_ENST00000534650.1_Missense_Mutation_p.F112S|KAT5_ENST00000352980.4_Missense_Mutation_p.F271S|KAT5_ENST00000377046.3_Missense_Mutation_p.F323S	NM_182710.2	NP_874369.1	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5	323					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)	21						GCCAAGTGTTTCCTTGACCAT	0.498000													78	97					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128484918	128484918	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:128484918C>T	ENST00000325888.8	+	21	3660	c.3399C>T	c.(3397-3399)atC>atT	p.I1133I	FLNC_ENST00000346177.6_Silent_p.I1133I	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1133					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CCATCAACATCCTGTTTGCTG	0.627000													57	81					0	0	1	0	0
DDX11	1663	broad.mit.edu	37	12	31236892	31236892	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:31236892C>T	ENST00000251758.5	+	3	541	c.290C>T	c.(289-291)tCc>tTc	p.S97F	DDX11_ENST00000545668.1_Missense_Mutation_p.S97F|DDX11_ENST00000228264.6_Missense_Mutation_p.S71F|DDX11_ENST00000407793.2_Missense_Mutation_p.S97F|DDX11_ENST00000350437.4_Missense_Mutation_p.S97F|DDX11_ENST00000542838.1_Missense_Mutation_p.S97F			Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	97	Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CTGTCTTCTTCCTGCGAAGGG	0.537000										Multiple Myeloma(12;0.14)			74	61					0	0	1	0	0
PIK3R5	23533	broad.mit.edu	37	17	8784239	8784239	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:8784239G>A	ENST00000447110.1	-	18	2602	c.2478C>T	c.(2476-2478)atC>atT	p.I826I	PIK3R5_ENST00000584803.1_Silent_p.I825I|PIK3R5_ENST00000581552.1_Silent_p.I826I	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	826					platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						CACTCTGCAGGATCTTTCTCT	0.572000													36	8					0	0	1	0	0
CCDC170	80129	broad.mit.edu	37	6	151936701	151936701	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:151936701G>A	ENST00000367290.5	+	10	1944	c.1855G>A	c.(1855-1857)Gaa>Aaa	p.E619K	CCDC170_ENST00000239374.7_Missense_Mutation_p.E612K			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	612																	GGATACCACAGAACATGAGGC	0.398000													84	76					0	0	1	0	0
CNN3	1266	broad.mit.edu	37	1	95367312	95367312	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:95367312A>G	ENST00000370206.4	-	5	797	c.414T>C	c.(412-414)atT>atC	p.I138I	CNN3_ENST00000487539.1_5'UTR|CNN3_ENST00000545882.1_Silent_p.I97I|CNN3_ENST00000538964.1_Silent_p.I138I|CNN3_ENST00000394202.4_Silent_p.I92I	NM_001839.3	NP_001830.1	Q15417	CNN3_HUMAN	calponin 3, acidic	138					actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|stomach(1)|urinary_tract(2)	18		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		CTCCAATGTCAATGGTTGTAT	0.368000													14	32					0	0	1	0	0
HTR1E	3354	broad.mit.edu	37	6	87725856	87725856	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:87725856C>T	ENST00000305344.4	+	2	1507	c.804C>T	c.(802-804)ttC>ttT	p.F268F	HTR1E_ENST00000369584.1_Silent_p.F268F	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	268					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	TCCCCCCCTTCGACAATGATC	0.507000													43	100					0	0	1	0	0
CAMK2G	818	broad.mit.edu	37	10	75576875	75576875	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:75576875C>T	ENST00000423381.1	-	21	1563	c.1439_splice	c.e21-1	p.T480_splice	CAMK2G_ENST00000305762.7_Splice_Site_p.T421_splice|CAMK2G_ENST00000351293.3_Splice_Site_p.T387_splice|CAMK2G_ENST00000322680.3_Splice_Site_p.T448_splice|CAMK2G_ENST00000472912.1_5'UTR|CAMK2G_ENST00000394762.2_Splice_Site_p.T425_splice|CAMK2G_ENST00000372765.1_Splice_Site_p.T408_splice|CAMK2G_ENST00000322635.3_Splice_Site_p.T419_splice	NM_001204492.1	NP_001191421.1	Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II gamma	450					insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity			kidney(2)|large_intestine(2)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	15	Prostate(51;0.0112)					CACAAATCTTCCTACAGGGAG	0.473000													67	22					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70224281	70224281	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:70224281C>T	ENST00000253925.7	+	26	3745	c.3530C>T	c.(3529-3531)cCa>cTa	p.P1177L	AP000487.5_ENST00000500185.2_RNA|PPFIA1_ENST00000530548.1_3'UTR|AP000487.5_ENST00000530690.1_RNA|PPFIA1_ENST00000389547.3_Missense_Mutation_p.P1177L	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	1177					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TCTATGCAGCCAAAGAAGATG	0.473000													35	49					0	0	1	0	0
SOX30	11063	broad.mit.edu	37	5	157065365	157065365	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:157065365G>A	ENST00000265007.6	-	4	2094	c.1753C>T	c.(1753-1755)Ccc>Tcc	p.P585S	SOX30_ENST00000519442.1_Missense_Mutation_p.P280S|SOX30_ENST00000311371.5_Intron	NM_178424.1	NP_848511.1	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30	585	Pro-rich.				regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	23	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGTGGAATGGGAGAAGCCTGG	0.547000													30	22					0	0	1	0	0
CCL22	6367	broad.mit.edu	37	16	57397432	57397432	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:57397432G>A	ENST00000219235.4	+	3	259	c.214G>A	c.(214-216)Gat>Aat	p.D72N		NM_002990.4	NP_002981.2	O00626	CCL22_HUMAN	chemokine (C-C motif) ligand 22	72					cell-cell signaling|chemotaxis|immune response|inflammatory response|response to virus|signal transduction	extracellular space	chemokine activity			large_intestine(1)|lung(1)|prostate(1)|skin(1)	4						AACCTTCAGGGATAAGGAGAT	0.522000													14	32					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167060703	167060703	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:167060703C>T	ENST00000375387.4	-	26	4879	c.4539G>A	c.(4537-4539)gtG>gtA	p.V1513V	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Silent_p.V1501V|SCN9A_ENST00000409435.1_Silent_p.V1512V|SCN9A_ENST00000303354.6_Silent_p.V1513V			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1512						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	CTTGATTTGTCACTAGGTCAA	0.328000													30	59					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131955666	131955666	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:131955666C>T	ENST00000286355.5	-	4	3376	c.1284G>A	c.(1282-1284)acG>acA	p.T428T	ADCY8_ENST00000377928.3_Silent_p.T428T|RP11-737F9.1_ENST00000523318.1_RNA	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	428					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CAGACAAGGTCGTGGAGAGGT	0.453000										HNSCC(32;0.087)			25	41					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20598203	20598203	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:20598203G>A	ENST00000504154.1	+	32	3738	c.3486G>A	c.(3484-3486)gtG>gtA	p.V1162V	SLIT2_ENST00000273739.5_Silent_p.V1175V|SLIT2_ENST00000503823.1_Silent_p.V1154V|SLIT2_ENST00000503837.1_Silent_p.V1158V	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1162	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TGGTTAGTGTGAATTTTATAA	0.403000													30	38					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121415582	121415582	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:121415582G>A	ENST00000393667.3	-	13	3898	c.3788C>T	c.(3787-3789)tCt>tTt	p.S1263F	GOLGB1_ENST00000340645.5_Missense_Mutation_p.S1258F	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	1258					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TGGAGTGGAAGAACACGATTC	0.453000													55	70					0	0	1	0	0
KCNJ8	3764	broad.mit.edu	37	12	21926284	21926284	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:21926284G>A	ENST00000240662.2	-	2	612	c.267C>T	c.(265-267)atC>atT	p.I89I		NM_004982.3	NP_004973.1	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 8	89						voltage-gated potassium channel complex				cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28					Levosimendan(DB00922)	GCCACCACATGATAGCGAAGA	0.512000											OREG0021704	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	51	34					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52569741	52569741	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:52569741C>T	ENST00000395489.2	-	14	1921	c.1525G>A	c.(1525-1527)Gaa>Aaa	p.E509K	A1CF_ENST00000373997.3_Missense_Mutation_p.E508K|ASAH2B_ENST00000483649.1_Intron|A1CF_ENST00000395495.1_Missense_Mutation_p.E461K|A1CF_ENST00000373993.1_Missense_Mutation_p.E516K|A1CF_ENST00000374001.1_Missense_Mutation_p.E508K|A1CF_ENST00000373995.3_Missense_Mutation_p.E516K|A1CF_ENST00000282641.2_Missense_Mutation_p.E516K	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	516					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding	p.E516K(1)|p.E508K(1)		NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						AGGGTGTATTCGGCTGCATAC	0.527000													33	8					0	0	1	0	0
EDNRA	1909	broad.mit.edu	37	4	148463691	148463691	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:148463691G>A	ENST00000324300.5	+	8	1720	c.1205G>A	c.(1204-1206)gGa>gAa	p.G402E	EDNRA_ENST00000511804.1_Missense_Mutation_p.G177E|EDNRA_ENST00000339690.5_3'UTR|EDNRA_ENST00000503721.1_3'UTR|EDNRA_ENST00000506066.1_Missense_Mutation_p.G293E|EDNRA_ENST00000358556.4_Missense_Mutation_p.G293E	NM_001957.3	NP_001948.1	P25101	EDNRA_HUMAN	endothelin receptor type A	402					activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)	17	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	CCCATGAACGGAACAAGCATC	0.532000													46	49					0	0	1	0	0
NFE2	4778	broad.mit.edu	37	12	54686212	54686212	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:54686212G>A	ENST00000540264.2	-	2	1577	c.1068C>T	c.(1066-1068)gcC>gcT	p.A356A	NFE2_ENST00000312156.4_Silent_p.A356A|NFE2_ENST00000435572.2_Silent_p.A356A|RP11-968A15.8_ENST00000553061.1_RNA|NFE2_ENST00000553070.1_Silent_p.A356A			Q16621	NFE2_HUMAN	nuclear factor, erythroid 2	356					blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(7)|upper_aerodigestive_tract(2)	16						TGGTCCCATCGGCAGCCTGTT	0.577000													18	61					0	0	1	0	0
CCR2	729230	broad.mit.edu	37	3	46399575	46399575	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:46399575C>T	ENST00000292301.4	+	2	1042	c.557C>T	c.(556-558)tCt>tTt	p.S186F	CCR2_ENST00000400888.2_Missense_Mutation_p.S186F|CCR2_ENST00000445132.2_Missense_Mutation_p.S186F|CCR2_ENST00000465202.1_Intron	NM_001123041.2	NP_001116513.2	P41597	CCR2_HUMAN	chemokine (C-C motif) receptor 2	186					astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|JAK-STAT cascade|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production|T-helper 17 cell chemotaxis	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			breast(3)|endometrium(1)|large_intestine(1)|liver(2)|lung(7)	14				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		AAAGAAGATTCTGTTTATGTC	0.468000													144	169					0	0	1	0	0
FNIP2	57600	broad.mit.edu	37	4	159790119	159790119	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:159790119C>T	ENST00000264433.6	+	13	2406	c.2331C>T	c.(2329-2331)tgC>tgT	p.C777C	FNIP2_ENST00000379346.3_Silent_p.C800C	NM_020840.1	NP_065891.1	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	777	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		AGAATGTTTGCTGTCCTCAGA	0.552000													71	53					0	0	1	0	0
ABAT	18	broad.mit.edu	37	16	8858601	8858601	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:8858601C>T	ENST00000396600.2	+	8	1392	c.454C>T	c.(454-456)Ccc>Tcc	p.P152S	ABAT_ENST00000425191.2_Missense_Mutation_p.P152S|ABAT_ENST00000268251.8_Missense_Mutation_p.P152S|ABAT_ENST00000569156.1_Missense_Mutation_p.P152S|ABAT_ENST00000567812.1_Missense_Mutation_p.P167S	NM_000663.4	NP_000654.2	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase	152					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	26					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	ACAGGTGGCTCCCAAAGGGAT	0.597000													35	69					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169535147	169535147	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:169535147C>T	ENST00000306268.6	+	2	730	c.669C>T	c.(667-669)tcC>tcT	p.S223S	FOXI1_ENST00000449804.2_Intron			Q12951	FOXI1_HUMAN	forkhead box I1	223					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGATGTTTCCTCTAGCACAG	0.512000									Pendred syndrome				18	47					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53678728	53678728	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:53678728A>G	ENST00000396424.3	-	3	201	c.112T>C	c.(112-114)Ttg>Ctg	p.L38L	ZNF665_ENST00000600412.1_Intron	NM_024733.3	NP_079009.3	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		TAATTCTCCAACATGACGTCC	0.468000													98	98					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24774618	24774618	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:24774618G>A	ENST00000221166.5	+	3	2032	c.1250G>A	c.(1249-1251)gGa>gAa	p.G417E	NEFM_ENST00000518131.1_Missense_Mutation_p.G417E|NEFM_ENST00000433454.2_Missense_Mutation_p.G41E|NEFM_ENST00000521540.1_3'UTR|NEFM_ENST00000437366.2_Missense_Mutation_p.G417E			P07197	NFM_HUMAN	neurofilament, medium polypeptide	417	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		ACATTTGCAGGAAGCATCACT	0.438000													29	6					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62257029	62257029	+	Missense_Mutation	SNP	T	T	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:62257029T>G	ENST00000261517.5	-	31	3156	c.3083A>C	c.(3082-3084)cAa>cCa	p.Q1028P	VPS13C_ENST00000395896.4_Missense_Mutation_p.Q1028P|VPS13C_ENST00000249837.3_Missense_Mutation_p.Q985P|VPS13C_ENST00000395898.3_Missense_Mutation_p.Q985P	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	1028					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						AGCTTGTGTTTGCAGCAACAG	0.363000													46	50					0	0	1	0	0
MAB21L1	4081	broad.mit.edu	37	13	36049891	36049891	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:36049891G>A	ENST00000379919.4	-	1	941	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	NBEA_ENST00000310336.4_Intron|NBEA_ENST00000400445.3_Intron|NBEA_ENST00000379939.2_Intron|NBEA_ENST00000540320.1_Intron	NM_005584.4	NP_005575.1	Q13394	MB211_HUMAN	mab-21-like 1 (C. elegans)	129					anatomical structure morphogenesis	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	20		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		AACCTGGACCGGATTTTGCGC	0.577000													17	61					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125058037	125058037	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:125058037G>A	ENST00000522917.1	+	21	2825	c.2619G>A	c.(2617-2619)tgG>tgA	p.W873*	FER1L6_ENST00000399018.1_Nonsense_Mutation_p.W873*	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	873	C2 3.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CTCCGACCTGGAACCAGATGC	0.502000													163	189					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143018858	143018858	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:143018858G>A	ENST00000343257.2	+	5	700	c.613G>A	c.(613-615)Gaa>Aaa	p.E205K	CLCN1_ENST00000495612.1_3'UTR	NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	205					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					TGTCCTGAAGGAATACCTCAC	0.532000													28	16					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100346061	100346061	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:100346061G>A	ENST00000542585.1	+	0	1365				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCCGTCCATGGCATGGGCCCT	0.582000													10	19					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76532518	76532518	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:76532518C>T	ENST00000307431.8	+	16	2674	c.2289C>T	c.(2287-2289)atC>atT	p.I763I	CNTNAP4_ENST00000377504.4_Silent_p.I715I|CNTNAP4_ENST00000478060.1_Silent_p.I691I|CNTNAP4_ENST00000476707.1_Silent_p.I767I|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	764	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						TAACTAAGATCGTGATTACAG	0.403000													14	37					0	0	1	0	0
DYM	54808	broad.mit.edu	37	18	46812894	46812894	+	Missense_Mutation	SNP	G	G	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:46812894G>T	ENST00000269445.6	-	9	1313	c.856C>A	c.(856-858)Ctg>Atg	p.L286M	DYM_ENST00000442713.2_Missense_Mutation_p.L96M	NM_017653.3	NP_060123.3	Q7RTS9	DYM_HUMAN	dymeclin	286						Golgi apparatus				NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	18						AGCAGAAGCAGGAGACTCTGG	0.547000													56	64					2.27459e-33	2.30879e-33	1	1	0
SPTBN2	6712	broad.mit.edu	37	11	66457360	66457360	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:66457360C>T	ENST00000533211.1	-	29	6196	c.5865G>A	c.(5863-5865)gaG>gaA	p.E1955E	SPTBN2_ENST00000529997.1_Silent_p.E1955E|SPTBN2_ENST00000309996.2_Silent_p.E1955E			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1955					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						GGGCCTCTATCTCTGCCTTGA	0.632000													56	50					0	0	1	0	0
MTTP	4547	broad.mit.edu	37	4	100518276	100518276	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:100518276C>T	ENST00000457717.1	+	9	1218	c.962C>T	c.(961-963)tCc>tTc	p.S321F	MTTP_ENST00000265517.5_Missense_Mutation_p.S321F|MTTP_ENST00000511045.1_Missense_Mutation_p.S348F|RP11-766F14.1_ENST00000508578.1_RNA	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	321	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	GACAACCTTTCCAAGGCTGAG	0.483000													76	81					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247769160	247769160	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:247769160G>A	ENST00000320002.2	+	1	305	c.273G>A	c.(271-273)acG>acA	p.T91T	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CAAAGAAGACGATCACTTACG	0.463000													156	31					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54373514	54373514	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:54373514C>T	ENST00000306888.2	-	3	708	c.457G>A	c.(457-459)Gaa>Aaa	p.E153K	LNX1-AS1_ENST00000514364.1_RNA|LNX1-AS1_ENST00000510785.1_RNA|LNX1-AS1_ENST00000511989.1_RNA|LNX1_ENST00000263925.7_Missense_Mutation_p.E249K|FIP1L1_ENST00000507166.1_Intron	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	249						cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TCAGAATTTTCCCTGCCCTGG	0.488000													53	59					0	0	1	0	0
AMY2A	279	broad.mit.edu	37	1	104160207	104160207	+	Missense_Mutation	SNP	C	C	A	rs147709536		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:104160207C>A	ENST00000414303.2	+	1	209	c.145C>A	c.(145-147)Ccg>Acg	p.P49T		NM_000699.2	NP_000690.1	P04746	AMYP_HUMAN	amylase, alpha 2A (pancreatic)	49					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			endometrium(3)|kidney(1)|large_intestine(5)|liver(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	ATATTTAGCTCCGAAGGGATT	0.413000													134	147					2.92151e-79	2.97711e-79	1	1	0
ARHGEF18	23370	broad.mit.edu	37	19	7527133	7527133	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:7527133C>T	ENST00000359920.6	+	11	2237	c.1984C>T	c.(1984-1986)Ctg>Ttg	p.L662L	ARHGEF18_ENST00000319670.9_Silent_p.L504L|CTD-2207O23.3_ENST00000593531.1_Silent_p.T619T	NM_001130955.1	NP_001124427.1	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 18	662					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	23		Renal(5;0.0902)				CCTCGAAGACCTGCCCCAGCC	0.602000													59	68					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117691547	117691547	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:117691547G>A	ENST00000317775.6	-	17	3229	c.2544C>T	c.(2542-2544)gtC>gtT	p.V848V	NOS1_ENST00000338101.4_Silent_p.V882V|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	848	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TGTTGAATCGGACCTTGTAGC	0.547000													36	34					0	0	1	0	0
STXBP5	134957	broad.mit.edu	37	6	147646216	147646216	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:147646216G>A	ENST00000367481.3	+	17	2032	c.1924G>A	c.(1924-1926)Gga>Aga	p.G642R	STXBP5_ENST00000321680.6_Missense_Mutation_p.G642R|STXBP5_ENST00000367480.3_Missense_Mutation_p.G642R|STXBP5_ENST00000179882.6_Missense_Mutation_p.G313R	NM_139244.4	NP_640337.3	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn)	642					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	42		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		TTCTTCCTATGGACTGTAAGT	0.363000													31	23					0	0	1	0	0
HNF1A	6927	broad.mit.edu	37	12	121431475	121431475	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:121431475G>A	ENST00000257555.6	+	3	905	c.679G>A	c.(679-681)Gag>Aag	p.E227K	HNF1A_ENST00000543427.1_Missense_Mutation_p.E110K|HNF1A_ENST00000538626.1_Intron|HNF1A_ENST00000402929.1_Missense_Mutation_p.E227K|HNF1A_ENST00000400024.2_Missense_Mutation_p.E227K|HNF1A_ENST00000541395.1_Missense_Mutation_p.E227K|HNF1A_ENST00000544413.1_Missense_Mutation_p.E227K			P20823	HNF1A_HUMAN	HNF1 homeobox A	227					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(8)|large_intestine(19)|liver(175)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	221	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCCTAGCAAGGAGGAGCGAGA	0.602000									Hepatic Adenoma, Familial Clustering of				20	21					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112647831	112647831	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:112647831T>A	ENST00000550722.1	-	50	7812	c.7417A>T	c.(7417-7419)Acc>Tcc	p.T2473S	HECTD4_ENST00000430131.2_Missense_Mutation_p.T2197S|HECTD4_ENST00000377560.5_Missense_Mutation_p.T2447S	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TGCTGAGCGGTGGCCACGGCA	0.532000													10	16					0	0	1	0	0
IGSF8	93185	broad.mit.edu	37	1	160061620	160061620	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:160061620T>A	ENST00000368086.1	-	6	2051	c.1835A>T	c.(1834-1836)aAa>aTa	p.K612I	IGSF8_ENST00000314485.7_Missense_Mutation_p.K612I			Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	612					cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(19)|pancreas(1)|prostate(1)|skin(1)	33	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GGATCACCGTTTTCGAAGCCT	0.557000													36	48					0	0	1	0	0
DMPK	1760	broad.mit.edu	37	19	46275920	46275920	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:46275920C>T	ENST00000600757.1	-	9	2025	c.1338G>A	c.(1336-1338)tcG>tcA	p.S446S	DMPK_ENST00000291270.4_Silent_p.S441S|DMPK_ENST00000447742.2_Silent_p.S436S|DMPK_ENST00000343373.4_Silent_p.S451S|DMPK_ENST00000354227.5_Silent_p.S436S|DMPK_ENST00000458663.2_Silent_p.S436S			Q09013	DMPK_HUMAN	dystrophia myotonica-protein kinase	451					regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(5)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)|urinary_tract(2)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		GTGGGGACACCGAGGGCTCCA	0.642000													11	24					0	0	1	0	0
HCN3	57657	broad.mit.edu	37	1	155257005	155257005	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:155257005C>T	ENST00000368358.3	+	7	1527	c.1519C>T	c.(1519-1521)Cgg>Tgg	p.R507W	HCN3_ENST00000496230.1_Intron	NM_020897.1	NP_065948.1	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 3	507						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGCCAGTGTTCGGGCTGACAC	0.577000													31	35					0	0	1	0	0
HPS5	11234	broad.mit.edu	37	11	18319221	18319221	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:18319221G>A	ENST00000396253.3	-	10	1328	c.866C>T	c.(865-867)tCt>tTt	p.S289F	HPS5_ENST00000531848.1_Missense_Mutation_p.S289F|HPS5_ENST00000438420.2_Missense_Mutation_p.S289F|HPS5_ENST00000349215.3_Missense_Mutation_p.S403F	NM_007216.3	NP_009147.3	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5	403						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						GTCCAGCTGAGATTTCAAATG	0.353000									Hermansky-Pudlak syndrome				58	42					0	0	1	0	0
USP53	54532	broad.mit.edu	37	4	120193172	120193172	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:120193172A>G	ENST00000450251.1	+	12	2701	c.2157A>G	c.(2155-2157)aaA>aaG	p.K719K	USP53_ENST00000274030.6_Silent_p.K719K			Q70EK8	UBP53_HUMAN	ubiquitin specific peptidase 53	719					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	27						GTGGTGTTAAAGAAACAGTAT	0.348000													36	83					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123848215	123848215	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:123848215C>T	ENST00000531945.1	-	1	273	c.184G>A	c.(184-186)Gtg>Atg	p.V62M		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TCAGAGCCCACAGTTAGGAGG	0.527000													12	20					0	0	1	0	0
MUTYH	4595	broad.mit.edu	37	1	45798487	45798487	+	Missense_Mutation	SNP	G	G	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:45798487G>C	ENST00000450313.1	-	7	739	c.524C>G	c.(523-525)gCt>gGt	p.A175G	MUTYH_ENST00000355498.2_Missense_Mutation_p.A147G|MUTYH_ENST00000372104.1_Missense_Mutation_p.A147G|MUTYH_ENST00000529984.1_Silent_p.G45G|MUTYH_ENST00000354383.6_Missense_Mutation_p.A148G|MUTYH_ENST00000372115.3_Missense_Mutation_p.A161G|MUTYH_ENST00000372098.3_Missense_Mutation_p.A172G|MUTYH_ENST00000528332.2_Silent_p.G59G|MUTYH_ENST00000456914.2_Missense_Mutation_p.A147G|MUTYH_ENST00000531105.1_Intron|MUTYH_ENST00000372100.5_Missense_Mutation_p.A158G|MUTYH_ENST00000488731.2_Silent_p.G45G|MUTYH_ENST00000372110.3_Missense_Mutation_p.A162G|MUTYH_ENST00000448481.1_Missense_Mutation_p.A158G	NM_001128425.1|NM_012222.2	NP_001121897.1|NP_036354.1	Q9UIF7	MUTYH_HUMAN	mutY homolog	172					depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					GCCCAGGCCAGCCCAGAGTTG	0.577000			Mis			colorectal		Base excision repair (BER), DNA glycosylases	MUTYH-associated polyposis				33	132					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32183145	32183145	+	Missense_Mutation	SNP	G	G	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:32183145G>T	ENST00000375023.3	-	12	2017	c.1879C>A	c.(1879-1881)Ccc>Acc	p.P627T		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	627	EGF-like 16.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GCACACAGGGGAACCTCACAG	0.557000													3	14					2.56e-06	2.56661e-06	1	1	0
SEC14L5	9717	broad.mit.edu	37	16	5046880	5046880	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:5046880C>T	ENST00000251170.7	+	8	985	c.805C>T	c.(805-807)Cgg>Tgg	p.R269W		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	269						integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						GCACATCCTTCGGTTCCTGCG	0.547000													14	15					0	0	1	0	0
DHRS7C	201140	broad.mit.edu	37	17	9680577	9680577	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:9680577C>T	ENST00000330255.4	-	4	519	c.507G>A	c.(505-507)cgG>cgA	p.R169R	DHRS7C_ENST00000571134.1_Silent_p.R168R	NM_001220493.1	NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	169						extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						GGCCTGTTCTCCGGGAGATCA	0.458000													24	30					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22729163	22729163	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:22729163G>A	ENST00000508166.1	+	0	160				GBA3_ENST00000511446.1_RNA|GBA3_ENST00000503442.1_RNA	NM_020973.4	NP_066024.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TCTCTGGAGTGATAGGCTTCT	0.448000													142	168					0	0	1	0	0
DIO2	1734	broad.mit.edu	37	14	80669068	80669068	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:80669068G>A	ENST00000557010.1	-	4	1171	c.786C>T	c.(784-786)ttC>ttT	p.F262F	DIO2_ENST00000422005.3_3'UTR|DIO2_ENST00000557125.1_3'UTR|DIO2_ENST00000555750.1_Silent_p.F298F|DIO2_ENST00000438257.4_Silent_p.F262F	NM_000793.5|NM_001242502.1|NM_001242503.1	NP_000784.2|NP_001229431.1|NP_001229432.1	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II	262					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(14)|skin(1)|stomach(1)	25				BRCA - Breast invasive adenocarcinoma(234;0.0281)		ATCTCTTGCTGAAATTCTTCT	0.383000													12	12					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				38	43					0	0	1	0	0
AMDHD2	51005	broad.mit.edu	37	16	2577827	2577827	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:2577827G>A	ENST00000302956.4	+	5	563	c.469G>A	c.(469-471)Gag>Aag	p.E157K	AMDHD2_ENST00000413459.3_Missense_Mutation_p.E157K|AMDHD2_ENST00000293971.6_Missense_Mutation_p.E157K|ATP6C_ENST00000569317.1_Missense_Mutation_p.110_110insK|CEMP1_ENST00000382350.1_Intron|AMDHD2_ENST00000565570.1_Intron			Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2	157					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(3)|skin(2)|urinary_tract(2)	19						CGCGCACCCCGAGGCCCACCT	0.697000													11	17					0	0	1	0	0
COL9A2	1298	broad.mit.edu	37	1	40771393	40771393	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:40771393C>T	ENST00000372748.3	-	21	1197	c.1101G>A	c.(1099-1101)ggG>ggA	p.G367G		NM_001852.3	NP_001843.1	Q14055	CO9A2_HUMAN	collagen, type IX, alpha 2	367	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(4)|stomach(2)|urinary_tract(2)	22	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			TTACCTCTTTCCCAGGGGGAC	0.617000													30	45					0	0	1	0	0
LDHAL6A	160287	broad.mit.edu	37	11	18498019	18498019	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:18498019G>A	ENST00000280706.2	+	5	1478	c.681G>A	c.(679-681)tgG>tgA	p.W227*	LDHAL6A_ENST00000396213.3_Nonsense_Mutation_p.W227*|TSG101_ENST00000536719.1_Intron	NM_144972.4	NP_659409.2	Q6ZMR3	LDH6A_HUMAN	lactate dehydrogenase A-like 6A	227					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity			large_intestine(3)|lung(9)|urinary_tract(1)	13					NADH(DB00157)	CTGAGCAGTGGGAAAATGTCC	0.418000													44	60					0	0	1	0	0
H2AFY2	55506	broad.mit.edu	37	10	71835473	71835473	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:71835473G>A	ENST00000373255.4	+	2	323	c.59G>A	c.(58-60)gGt>gAt	p.G20D		NM_018649.2	NP_061119.1	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	20	Histone H2A.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(4)|skin(1)	15						GCTAGGGCAGGTGTCATCTTT	0.557000													30	8					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6527122	6527122	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:6527122C>T	ENST00000263125.5	-	10	1109	c.1010G>A	c.(1009-1011)gGa>gAa	p.G337E	PRKCQ_ENST00000539722.1_Missense_Mutation_p.G212E|PRKCQ_ENST00000397176.2_Missense_Mutation_p.G337E	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	337					axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						ACCTCTTTTTCCCGGTGTCGG	0.433000													74	23					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106116851	106116851	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:106116851C>T	ENST00000357242.5	+	21	3193	c.3019C>T	c.(3019-3021)Cct>Tct	p.P1007S	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.P1001S	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	1007						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TCATGAGGACCCTGAAGAAGA	0.368000													47	1					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67320515	67320515	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:67320515C>T	ENST00000360461.5	+	15	5235	c.2700C>T	c.(2698-2700)ttC>ttT	p.F900F	PLEKHG4_ENST00000450733.1_Silent_p.F819F|PLEKHG4_ENST00000427155.2_Silent_p.F900F|PLEKHG4_ENST00000379344.3_Silent_p.F900F	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	900	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		TTGTGCACTTCCAGCTGCGGC	0.662000													4	7					0	0	1	0	0
TRMT10B	158234	broad.mit.edu	37	9	37762051	37762051	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:37762051C>T	ENST00000297994.3	+	2	188	c.123C>T	c.(121-123)atC>atT	p.I41I	TRMT10B_ENST00000377754.2_5'UTR|TRMT10B_ENST00000377753.2_Silent_p.I41I|TRMT10B_ENST00000537911.1_Silent_p.I41I|RP11-613M10.9_ENST00000540557.1_Intron	NM_144964.2	NP_659401.2			tRNA methyltransferase 10 homolog B (S. cerevisiae)																		TTCTGCAGATCGATGCGGAAG	0.567000													17	3					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186544635	186544635	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:186544635G>A	ENST00000431808.1	-	14	2499	c.1936C>T	c.(1936-1938)Cac>Tac	p.H646Y	SORBS2_ENST00000418609.1_Missense_Mutation_p.H550Y|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000284776.7_Missense_Mutation_p.H646Y|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000355634.5_Missense_Mutation_p.H746Y|SORBS2_ENST00000393528.3_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	646	His-rich.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		tggtggtggtggtgatggtgg	0.527000													45	59					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169511839	169511839	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:169511839G>A	ENST00000367796.3	-	13	2705	c.2504C>T	c.(2503-2505)cCa>cTa	p.P835L	F5_ENST00000367797.3_Missense_Mutation_p.P830L			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	830	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TTCAGAATATGGGCTGGAATG	0.488000													100	132					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233898955	233898955	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:233898955G>A	ENST00000233840.3	+	2	331	c.331G>A	c.(331-333)Gag>Aag	p.E111K		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	111							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		GCAAGTCACGGAGCAACAGCA	0.627000													77	49					0	0	1	0	0
CLEC17A	388512	broad.mit.edu	37	19	14706128	14706128	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:14706128G>A	ENST00000547437.1	+	8	522		c.e8+1		CLEC17A_ENST00000397439.2_Splice_Site|CLEC17A_ENST00000417570.1_Splice_Site	NM_207390.3	NP_997273.3	Q6ZS10	CL17A_HUMAN	C-type lectin domain family 17, member A							cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity										TCCCTGGCCGGTAAGTGTCCT	0.502000													104	141					0	0	1	0	0
UXT	8409	broad.mit.edu	37	X	47516988	47516988	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:47516988G>A	ENST00000335890.2	-	3	420	c.267C>T	c.(265-267)ttC>ttT	p.F89F	UXT_ENST00000333119.3_Silent_p.F77F	NM_153477.2	NP_705582.1	Q9UBK9	UXT_HUMAN	ubiquitously-expressed, prefoldin-like chaperone	77					centrosome organization|mitochondrion transport along microtubule|protein folding	centrosome|nucleus|prefoldin complex	beta-tubulin binding|microtubule binding|unfolded protein binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(1)	6						TGTCAACGAAGAAGTTACAGC	0.498000													15	2					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037945	75037945	+	Missense_Mutation	SNP	T	T	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:75037945T>G	ENST00000326665.5	-	14	3667	c.3449A>C	c.(3448-3450)aAa>aCa	p.K1150T	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1150	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CACTGTCTCTTTTAGTGAATC	0.473000													39	57					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92523233	92523233	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:92523233G>A	ENST00000298047.6	+	7	4477	c.4460G>A	c.(4459-4461)aGa>aAa	p.R1487K	FAT3_ENST00000525166.1_Missense_Mutation_p.R1337K|FAT3_ENST00000409404.2_Missense_Mutation_p.R1487K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1487	Cadherin 14.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCCACAGATAGAGATGAGAAG	0.473000										TCGA Ovarian(4;0.039)			85	111					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69796478	69796478	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:69796478G>A	ENST00000251566.4	-	5	1120	c.1090C>T	c.(1090-1092)Ccc>Tcc	p.P364S	UGT2A3_ENST00000420231.2_Missense_Mutation_p.P75S	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	364						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TTGGTTTTGGGATGACCTAGT	0.358000													37	27					0	0	1	0	0
EEF1G	1937	broad.mit.edu	37	11	62327780	62327780	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:62327780G>A	ENST00000378019.3	-	8	1244	c.1154C>T	c.(1153-1155)aCc>aTc	p.T385I	EEF1G_ENST00000329251.4_Missense_Mutation_p.T335I|MIR3654_ENST00000496634.2_3'UTR			P26641	EF1G_HUMAN	eukaryotic translation elongation factor 1 gamma	335	EF-1-gamma C-terminal.				response to virus	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GCTCATGAAGGTCTGAGTGAG	0.493000													17	18					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28276434	28276434	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:28276434C>T	ENST00000305242.5	-	3	355	c.263G>A	c.(262-264)gGa>gAa	p.G88E		NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	88							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						CAAAGGCTGTCCATTTTTATC	0.343000													6	31					0	0	1	0	0
AGXT2	64902	broad.mit.edu	37	5	35014124	35014124	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:35014124C>T	ENST00000231420.6	-	10	1264	c.1064G>A	c.(1063-1065)gGc>gAc	p.G355D		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	355					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	CATGGGAAAGCCATTCCCAAT	0.527000													69	36					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771784	143771784	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:143771784C>T	ENST00000408898.2	+	1	510	c.472C>T	c.(472-474)Cat>Tat	p.H158Y		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					GGCCCTTGTCCATCTAGTGTT	0.453000													86	106					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38227207	38227207	+	Nonsense_Mutation	SNP	G	G	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:38227207G>T	ENST00000373048.4	-	3	719	c.720C>A	c.(718-720)tgC>tgA	p.C240*	EPHA10_ENST00000319637.6_Nonsense_Mutation_p.C240*|EPHA10_ENST00000427468.2_Nonsense_Mutation_p.C240*	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	240						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGTGCGCCACGCACGTTCCGG	0.726000													18	25					8.28177e-16	8.35711e-16	1	1	0
CASK	8573	broad.mit.edu	37	X	41524605	41524605	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:41524605G>A	ENST00000318588.9	-	7	678	c.633C>T	c.(631-633)atC>atT	p.I211I	CASK_ENST00000378163.1_Silent_p.I211I|CASK_ENST00000378166.4_Silent_p.I211I|CASK_ENST00000378154.1_Silent_p.I211I|CASK_ENST00000421587.2_Silent_p.I211I|CASK_ENST00000442742.2_Silent_p.I211I|CASK_ENST00000378158.1_Silent_p.I211I|CASK_ENST00000361962.4_Silent_p.I211I			O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	211	Protein kinase.				cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|ovary(3)|prostate(1)|stomach(1)	32						CACTGAGCAGGATAAAAAGGA	0.418000													13	2					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72685590	72685590	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:72685590C>T	ENST00000425256.1	-	0	68					NR_002164.1																						ATTTCCGTTTCGCCCGAGTGG	0.433000													70	84					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11561564	11561564	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:11561564C>T	ENST00000294484.6	+	2	653	c.515C>T	c.(514-516)cCc>cTc	p.P172L	PTCHD2_ENST00000389575.3_Missense_Mutation_p.P172L	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	172					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TCCCGAGCCCCCCGCGTCATC	0.672000													20	18					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78399234	78399234	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:78399234G>A	ENST00000278550.7	-	29	5587	c.5125C>T	c.(5125-5127)Cct>Tct	p.P1709S		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TGGCCAGTAGGGAAGGTCACA	0.507000													80	124					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36779975	36779975	+	Missense_Mutation	SNP	G	G	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:36779975G>C	ENST00000416516.2	-	2	666	c.176C>G	c.(175-177)aCc>aGc	p.T59S		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	59						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						GCTCTTGGGGGTCTCGGTCTC	0.612000													60	83					0	0	1	0	0
SLC4A11	83959	broad.mit.edu	37	20	3211214	3211214	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:3211214G>A	ENST00000380059.3	-	12	1592	c.1491C>T	c.(1489-1491)ttC>ttT	p.F497F	SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000380056.3_Silent_p.F470F|SLC4A11_ENST00000539553.1_Silent_p.F454F	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	470	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						AAAGCGCAAGGAAGAAACTAT	0.547000													82	80					0	0	1	0	0
LARP1	23367	broad.mit.edu	37	5	154183801	154183801	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:154183801C>T	ENST00000336314.4	+	14	2273	c.2249C>T	c.(2248-2250)cCc>cTc	p.P750L		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	827							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCAAACCCACCCTTGGAGAGC	0.532000													22	104					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411646	126411646	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:126411646G>A	ENST00000394329.3	+	17	13682	c.13669G>A	c.(13669-13671)Gat>Aat	p.D4557N	FAT4_ENST00000335110.5_Missense_Mutation_p.D2798N	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4557					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CGTTGCTTTTGATGACCCTGA	0.473000													50	67					0	0	1	0	0
ITFG3	83986	broad.mit.edu	37	16	314958	314958	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:314958G>A	ENST00000399932.3	+	13	2047	c.1596G>A	c.(1594-1596)ggG>ggA	p.G532G	ITFG3_ENST00000301678.3_Silent_p.G532G|ITFG3_ENST00000301679.2_Intron|ITFG3_ENST00000442458.2_Intron|ITFG3_ENST00000600536.1_Intron|ITFG3_ENST00000450082.2_Intron			Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	532						integral to membrane				central_nervous_system(3)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				GTGAGGGTGGGCCAGACAGTG	0.662000													25	47					0	0	1	0	0
SLC4A7	9497	broad.mit.edu	37	3	27436502	27436502	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:27436502G>A	ENST00000295736.5	-	19	2851	c.2781C>T	c.(2779-2781)atC>atT	p.I927I	SLC4A7_ENST00000445684.1_Silent_p.I923I|SLC4A7_ENST00000446700.1_Silent_p.I919I|SLC4A7_ENST00000428386.1_Silent_p.I803I|SLC4A7_ENST00000388777.4_Silent_p.I477I|SLC4A7_ENST00000437179.1_Silent_p.I808I|SLC4A7_ENST00000435667.2_Silent_p.I812I|SLC4A7_ENST00000425128.2_3'UTR|SLC4A7_ENST00000440156.1_Silent_p.I923I|SLC4A7_ENST00000454389.1_Silent_p.I936I|SLC4A7_ENST00000455077.1_Silent_p.I808I	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	927						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						GATCCATAAAGATGAGAATGG	0.383000													25	26					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176008463	176008463	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:176008463G>A	ENST00000510636.1	+	17	2212	c.1938G>A	c.(1936-1938)ggG>ggA	p.G646G	CDHR2_ENST00000506348.1_Silent_p.G646G|CDHR2_ENST00000261944.5_Silent_p.G646G	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	646	Cadherin 6.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding	p.G646G(1)		breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						GAAACCTGGGGCCCCTGGACA	0.632000													18	37					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89400085	89400085	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:89400085C>T	ENST00000439576.2	+	12	4643	c.4269C>T	c.(4267-4269)gcC>gcT	p.A1423A	ACAN_ENST00000559004.1_Silent_p.A1423A|ACAN_ENST00000561243.1_Silent_p.A1423A|ACAN_ENST00000352105.7_Silent_p.A1423A	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1423					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGACTACTGCCCCTGGAGTAG	0.532000													122	175					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325190	150325190	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:150325190C>T	ENST00000328902.5	-	3	712	c.496G>A	c.(496-498)Gaa>Aaa	p.E166K	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	166							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCCAGGTCTTCCTTCCGGGTG	0.627000													126	168					0	0	1	0	0
ZNF687	57592	broad.mit.edu	37	1	151259006	151259006	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:151259006C>T	ENST00000368879.2	+	2	337	c.239C>T	c.(238-240)tCt>tTt	p.S80F		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	80					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCAGACATTTCTGTAGTCAGT	0.602000													31	43					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179441255	179441255	+	Splice_Site	SNP	C	C	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179441255C>G	ENST00000589042.1	-	325	69940		c.e325+1		TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Splice_Site|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Splice_Site|TTN_ENST00000342992.6_Splice_Site|TTN_ENST00000460472.2_Splice_Site|TTN_ENST00000342175.6_Splice_Site	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAATACTAACATGCTGCATC	0.398000													83	54					0	0	1	0	0
PRKAG3	53632	broad.mit.edu	37	2	219693314	219693314	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:219693314C>T	ENST00000439262.2	-	5	663	c.568G>A	c.(568-570)Gcc>Acc	p.A190T	PRKAG3_ENST00000392098.3_Missense_Mutation_p.A215T|PRKAG3_ENST00000529249.1_Missense_Mutation_p.A215T|PRKAG3_ENST00000545803.1_Missense_Mutation_p.A31T	NM_017431.2	NP_059127.2	Q9UGI9	AAKG3_HUMAN	protein kinase, AMP-activated, gamma 3 non-catalytic subunit	215					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			large_intestine(7)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCAAAGAAGGCCTTCTTGATC	0.627000													12	37					0	0	1	0	0
PDZD9	255762	broad.mit.edu	37	16	21995787	21995787	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:21995787C>T	ENST00000286143.6	-	5	731	c.410G>A	c.(409-411)gGa>gAa	p.G137E	PDZD9_ENST00000424898.2_Missense_Mutation_p.G199E|PDZD9_ENST00000537222.2_Missense_Mutation_p.G139E			Q8IXQ8	PDZD9_HUMAN	PDZ domain containing 9	199										breast(3)|endometrium(2)|lung(3)|pancreas(1)	9						AATGTCTTTTCCTACACTAAT	0.433000													69	81					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603475	111603475	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:111603475C>T	ENST00000431670.2	+	2	962	c.551C>T	c.(550-552)tCc>tTc	p.S184F	PHLDB2_ENST00000477695.1_Missense_Mutation_p.S184F|PHLDB2_ENST00000393923.3_Missense_Mutation_p.S211F|PHLDB2_ENST00000412622.1_Missense_Mutation_p.S184F|PHLDB2_ENST00000481953.1_Missense_Mutation_p.S184F|PHLDB2_ENST00000478922.1_Missense_Mutation_p.S184F|PHLDB2_ENST00000393925.3_Missense_Mutation_p.S184F	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	184						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						AATGGAAGTTCCCTGAGTGAT	0.547000													31	37					0	0	1	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254404	30254404	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:30254404C>T	ENST00000361644.2	+	5	1100	c.363C>T	c.(361-363)ttC>ttT	p.F121F	MAGEB3_ENST00000378986.1_Silent_p.F121F	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	121	MAGE.									NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						TGGTGCAGTTCCTGATGGAAA	0.393000													37	5					0	0	1	0	0
MCHR2	84539	broad.mit.edu	37	6	100395759	100395759	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:100395759G>A	ENST00000281806.2	-	3	585	c.271C>T	c.(271-273)Cac>Tac	p.H91Y	MCHR2_ENST00000445970.1_Missense_Mutation_p.H91Y|MCHR2_ENST00000369212.1_Missense_Mutation_p.H91Y	NM_001040179.1	NP_001035269.1	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	91						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.H91Y(2)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	39		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		GCCCATTGGTGAATAAGAAAA	0.483000													48	54					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70071292	70071292	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:70071292T>C	ENST00000370598.1	+	29	4948	c.4127T>C	c.(4126-4128)tTg>tCg	p.L1376S	BAI3_ENST00000238918.8_Missense_Mutation_p.L582S|BAI3_ENST00000546190.1_Missense_Mutation_p.L340S	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1376					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				ATGCAGAATTTGCCCTTTGAA	0.418000													58	48					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158637763	158637763	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:158637763C>T	ENST00000368148.3	-	15	2103	c.1923G>A	c.(1921-1923)caG>caA	p.Q641Q	SPTA1_ENST00000368147.3_Silent_p.Q641Q	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	641					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GGCCAGTTTTCTGTATGTTTT	0.473000													55	84					0	0	1	0	0
PTBP1	5725	broad.mit.edu	37	19	805537	805537	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:805537T>A	ENST00000356948.6	+	9	1361	c.938T>A	c.(937-939)tTc>tAc	p.F313Y	PTBP1_ENST00000350092.4_Intron|PTBP1_ENST00000394601.4_Missense_Mutation_p.F306Y|PTBP1_ENST00000349038.4_Intron	NM_002819.4	NP_002810.1	P26599	PTBP1_HUMAN	polypyrimidine tract binding protein 1	297					negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)	19		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGCTGGTTTCCCTCCCACC	0.562000													75	128					0	0	1	0	0
ANKRD22	118932	broad.mit.edu	37	10	90588368	90588368	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:90588368T>A	ENST00000371930.4	-	3	479	c.269A>T	c.(268-270)tAt>tTt	p.Y90F		NM_144590.2	NP_653191.2	Q5VYY1	ANR22_HUMAN	ankyrin repeat domain 22	90										NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(3)	10		Colorectal(252;0.0163)		Colorectal(12;6.29e-05)|COAD - Colon adenocarcinoma(12;7.69e-05)		AATTAGTAGATAATCAATGAA	0.338000													83	16					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56297162	56297162	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:56297162G>A	ENST00000443188.1	-	12	3641	c.2931C>T	c.(2929-2931)atC>atT	p.I977I	NLRP11_ENST00000589093.1_Silent_p.I977I|NLRP11_ENST00000360133.3_Silent_p.I923I|NLRP11_ENST00000592953.1_Silent_p.I878I|NLRP11_ENST00000589824.2_Silent_p.I923I	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	977							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CAGACAGAAAGATCAAACTGG	0.418000													43	52					0	0	1	0	0
ZNF525	170958	broad.mit.edu	37	19	53885229	53885229	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:53885229C>T	ENST00000467003.1	+	4	1490	c.1289C>T	c.(1288-1290)cCt>cTt	p.P430L	ZNF525_ENST00000475179.1_Intron|ZNF525_ENST00000593918.1_Intron|ZNF525_ENST00000355326.3_Missense_Mutation_p.P184L|ZNF525_ENST00000474037.1_Missense_Mutation_p.P466L					zinc finger protein 525											endometrium(3)|kidney(3)|lung(3)	9						GGAGAGAAACCTTGCAAGTGT	0.373000													15	22					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39963692	39963692	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:39963692C>T	ENST00000599117.1	+	24	2563	c.2196C>T	c.(2194-2196)gcC>gcT	p.A732A	SUPT5H_ENST00000402194.2_Silent_p.A728A|SUPT5H_ENST00000432763.2_Silent_p.A732A|SUPT5H_ENST00000359191.6_Silent_p.A728A|SUPT5H_ENST00000598725.1_Silent_p.A732A			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	732	KOW 5.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity	p.A732A(1)		breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AGTCCACGGCCCGTGTGGAGC	0.677000													29	54					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138452990	138452990	+	Nonsense_Mutation	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:138452990C>A	ENST00000344876.4	-	1	639	c.253G>T	c.(253-255)Gaa>Taa	p.E85*	PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000412923.2_Nonsense_Mutation_p.E85*|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000507846.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	85	Cadherin 1.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					ATGCTGATTTCCCCATTATCC	0.433000													66	129					1.85135e-42	1.88411e-42	1	1	0
DAAM1	23002	broad.mit.edu	37	14	59797987	59797987	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:59797987C>T	ENST00000395125.1	+	13	1644	c.1621C>T	c.(1621-1623)Cct>Tct	p.P541S	DAAM1_ENST00000351081.1_Missense_Mutation_p.P541S|DAAM1_ENST00000360909.3_Missense_Mutation_p.P541S	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	541	FH1.|Pro-rich.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		AGGGCCCTTTCCTTCCTCTGT	0.592000													24	85					0	0	1	0	0
PDE7B	27115	broad.mit.edu	37	6	136476860	136476860	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:136476860G>A	ENST00000308191.6	+	8	978	c.675G>A	c.(673-675)ttG>ttA	p.L225L	RP13-143G15.4_ENST00000591521.1_RNA|RP13-143G15.4_ENST00000585946.1_RNA|RP13-143G15.4_ENST00000417643.1_RNA	NM_018945.3	NP_061818.1	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	225	Catalytic (By similarity).				signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	AGCCATTTTTGATAAAAACTA	0.542000													25	21					0	0	1	0	0
CORT	1325	broad.mit.edu	37	1	10510203	10510203	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:10510203C>T	ENST00000320498.4	+	1	233	c.73C>T	c.(73-75)Ccc>Tcc	p.P25S	APITD1-CORT_ENST00000465026.1_Intron|APITD1_ENST00000602296.1_Intron|CORT_ENST00000377049.3_5'UTR|APITD1-CORT_ENST00000400900.2_Intron|APITD1-CORT_ENST00000470413.2_Intron|APITD1_ENST00000602787.1_Intron					cortistatin											breast(1)|endometrium(1)|stomach(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0487)		GACCCAAGTCCCCAAAACATT	0.522000													90	155					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162421170	162421170	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:162421170G>A	ENST00000306100.5	-	12	1892	c.1456C>T	c.(1456-1458)Cag>Tag	p.Q486*	FSTL5_ENST00000427802.2_Nonsense_Mutation_p.Q476*|FSTL5_ENST00000379164.4_Nonsense_Mutation_p.Q485*|FSTL5_ENST00000536695.1_Nonsense_Mutation_p.Q485*	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	486						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ATACTTGCCTGAAATCCAAGG	0.318000													10	15					0	0	1	0	0
FCRL4	83417	broad.mit.edu	37	1	157557280	157557280	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:157557280G>A	ENST00000271532.1	-	5	768	c.633C>T	c.(631-633)agC>agT	p.S211S	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	211	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GTGTTTCACAGCTCAGGTTTA	0.502000													92	102					0	0	1	0	0
MIER1	57708	broad.mit.edu	37	1	67428787	67428787	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:67428787C>T	ENST00000357692.2	+	9	865	c.608C>T	c.(607-609)tCc>tTc	p.S203F	MIER1_ENST00000371014.1_Missense_Mutation_p.S239F|MIER1_ENST00000371018.3_Missense_Mutation_p.S203F|MIER1_ENST00000401042.3_Missense_Mutation_p.S186F|MIER1_ENST00000355356.3_Missense_Mutation_p.S186F|MIER1_ENST00000355977.6_Missense_Mutation_p.S123F|MIER1_ENST00000371016.1_Missense_Mutation_p.S203F|MIER1_ENST00000401041.1_Missense_Mutation_p.S239F	NM_001146110.1	NP_001139582.1	Q8N108	MIER1_HUMAN	mesoderm induction early response 1, transcriptional regulator	210	Glu-rich.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|urinary_tract(3)	15						ATGGTGGGCTCCATGTTTCAA	0.308000													21	31					0	0	1	0	0
ARSG	22901	broad.mit.edu	37	17	66391313	66391313	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:66391313C>T	ENST00000448504.2	+	10	1987	c.1191C>T	c.(1189-1191)ggC>ggT	p.G397G	ARSG_ENST00000582154.1_3'UTR|ARSG_ENST00000452479.2_Silent_p.G233G	NM_014960.4	NP_055775.2	Q96EG1	ARSG_HUMAN	arylsulfatase G	397					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			NS(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	26			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGCTCTTTGGCCGGTCACAGC	0.587000													41	63					0	0	1	0	0
NCAPG	64151	broad.mit.edu	37	4	17839387	17839387	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:17839387G>A	ENST00000251496.2	+	16	2605	c.2429G>A	c.(2428-2430)gGa>gAa	p.G810E		NM_022346.3	NP_071741.2	Q9BPX3	CND3_HUMAN	non-SMC condensin I complex, subunit G	810					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	27				STAD - Stomach adenocarcinoma(129;0.18)		AGACCAAGTGGATTAAATCCT	0.418000													74	86					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63970294	63970294	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:63970294C>T	ENST00000443617.2	-	37	6907	c.6820G>A	c.(6820-6822)Gag>Aag	p.E2274K	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	2274					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TCTTTGCTCTCCTTCTCCTCT	0.473000													29	30					0	0	1	0	0
LMOD2	442721	broad.mit.edu	37	7	123302538	123302538	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:123302538G>A	ENST00000458573.2	+	2	1055	c.898G>A	c.(898-900)Gag>Aag	p.E300K	LMOD2_ENST00000456238.2_Intron	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	300						cytoskeleton	actin binding|tropomyosin binding										GGTGCTCACGGAGCTGCGTTT	0.537000													49	53					0	0	1	0	0
TCERG1	10915	broad.mit.edu	37	5	145886624	145886624	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:145886624C>T	ENST00000296702.5	+	19	2802	c.2764C>T	c.(2764-2766)Cgt>Tgt	p.R922C	TCERG1_ENST00000394421.2_Missense_Mutation_p.R901C	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	922	FF 4.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTCTGATACTCGTAGGACCCT	0.393000													44	118					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56094071	56094071	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:56094071G>A	ENST00000257880.7	-	5	996	c.777C>T	c.(775-777)atC>atT	p.I259I	ITGA7_ENST00000257879.6_Intron|ITGA7_ENST00000394229.2_Intron|ITGA7_ENST00000553804.1_Silent_p.I259I|ITGA7_ENST00000394230.2_Silent_p.I259I|ITGA7_ENST00000555728.1_Silent_p.I259I|ITGA7_ENST00000347027.6_Intron|ITGA7_ENST00000452168.2_Silent_p.I162I			Q13683	ITA7_HUMAN	integrin, alpha 7	259					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CAGGGACCGGGATGAGGCGGG	0.647000													11	14					0	0	1	0	0
GABRG2	2566	broad.mit.edu	37	5	161524644	161524644	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:161524644G>A	ENST00000356592.3	+	4	788	c.327_splice	c.e4-1	p.E110_splice	GABRG2_ENST00000414552.2_Splice_Site_p.E110_splice|GABRG2_ENST00000361925.4_Splice_Site_p.E110_splice|GABRG2_ENST00000393933.4_Splice_Site_p.E15_splice	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	110					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		ATTAAAACAGGAATACACTAT	0.313000													33	27					0	0	1	0	0
GPATCH1	55094	broad.mit.edu	37	19	33592450	33592450	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:33592450C>T	ENST00000170564.2	+	9	1364	c.1050C>T	c.(1048-1050)tcC>tcT	p.S350S		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	350						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					ATGGATTTTCCTTGGCTTCTA	0.303000													20	37					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26286821	26286821	+	Missense_Mutation	SNP	C	C	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:26286821C>G	ENST00000335473.7	+	26	4663	c.4413C>G	c.(4411-4413)ttC>ttG	p.F1471L	CTA-125H2.2_ENST00000600211.1_RNA|MYO18B_ENST00000407587.2_Missense_Mutation_p.F1472L|CTA-125H2.2_ENST00000453457.2_RNA|MYO18B_ENST00000536101.1_Missense_Mutation_p.F1471L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1471	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TACAGGCCTTCCGGGAGGTCC	0.607000													19	17					0	0	1	0	0
OR4Q3	441669	broad.mit.edu	37	14	20216483	20216483	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:20216483G>A	ENST00000331723.1	+	1	897	c.897G>A	c.(895-897)atG>atA	p.M299I		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	299					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGACAGCTATGAAGAAGCTGA	0.388000													21	29					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61619602	61619602	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:61619602G>A	ENST00000583023.1	+	9	1966	c.1954_splice	c.e9-1	p.G652_splice	KCNH6_ENST00000456941.2_Splice_Site_p.G599_splice|KCNH6_ENST00000581784.1_Splice_Site_p.G599_splice|KCNH6_ENST00000314672.5_Splice_Site_p.G652_splice	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	652					regulation of transcription, DNA-dependent|signal transduction			p.G652E(1)		breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	TGGCTGGCAGGAAAGAATGAC	0.587000													30	44					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152697585	152697585	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:152697585G>A	ENST00000367255.5	-	58	9856	c.9255C>T	c.(9253-9255)atC>atT	p.I3085I	SYNE1_ENST00000265368.4_Silent_p.I3085I|SYNE1_ENST00000423061.1_Silent_p.I3092I|SYNE1_ENST00000341594.5_Silent_p.I3124I|SYNE1_ENST00000448038.1_Silent_p.I3092I	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3085					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGCGGTAGTGATTTTTGCAT	0.378000										HNSCC(10;0.0054)			40	25					0	0	1	0	0
ZNF347	84671	broad.mit.edu	37	19	53644336	53644336	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:53644336G>A	ENST00000452676.2	-	5	2174	c.1748C>T	c.(1747-1749)tCa>tTa	p.S583L	ZNF347_ENST00000334197.7_Missense_Mutation_p.S582L|ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000601469.2_Missense_Mutation_p.S583L	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	582					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		TGCAAGGTGTGAATTCTGAGT	0.408000													100	138					0	0	1	0	0
KRTAP4-12	83755	broad.mit.edu	37	17	39280338	39280338	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:39280338G>A	ENST00000394014.1	-	1	81	c.37C>T	c.(37-39)Cag>Tag	p.Q13*		NM_031854.2	NP_114060.1	Q9BQ66	KR412_HUMAN	keratin associated protein 4-12	13	31 X 5 AA repeats of C-C-[GRQVIL]-[SPTR]- [VSTQPC].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			CCACAGCCCTGGTCAGAGCAC	0.612000													67	95					0	0	1	0	0
TUSC3	7991	broad.mit.edu	37	8	15398068	15398068	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:15398068G>A	ENST00000382020.4	+	1	337	c.129G>A	c.(127-129)aaG>aaA	p.K43K	TUSC3_ENST00000509380.1_Silent_p.K43K|TUSC3_ENST00000506802.1_Silent_p.K43K|TUSC3_ENST00000503731.1_Silent_p.K43K|TUSC3_ENST00000503191.1_Intron	NM_178234.2	NP_839952.1	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3	43					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(10)|ovary(2)	28				Colorectal(111;0.113)		GAGGACAGAAGAAAAAGGAGG	0.677000													25	10					0	0	1	0	0
GIPC1	10755	broad.mit.edu	37	19	14591413	14591413	+	Missense_Mutation	SNP	A	A	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:14591413A>C	ENST00000393033.4	-	5	735	c.466T>G	c.(466-468)Ttc>Gtc	p.F156V	GIPC1_ENST00000393029.3_Missense_Mutation_p.F59V|GIPC1_ENST00000591349.1_Missense_Mutation_p.F59V|GIPC1_ENST00000393028.1_Missense_Mutation_p.F59V|GIPC1_ENST00000586027.1_Missense_Mutation_p.F156V|GIPC1_ENST00000345425.2_Missense_Mutation_p.F156V	NM_005716.3	NP_005707.1	O14908	GIPC1_HUMAN	GIPC PDZ domain containing family, member 1	156	PDZ.				endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding			endometrium(1)|lung(4)|upper_aerodigestive_tract(1)	6						ACCTTGATGAAGGCGTAGCCA	0.662000											OREG0025316	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	62	56					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	119988939	119988939	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:119988939G>A	ENST00000341846.5	-	7	2040	c.1619C>T	c.(1618-1620)tCc>tTc	p.S540F	TRIM29_ENST00000525887.1_5'UTR|TRIM29_ENST00000524816.3_Missense_Mutation_p.S106F|TRIM29_ENST00000529044.1_Missense_Mutation_p.S279F|TRIM29_ENST00000528870.1_Missense_Mutation_p.S73F|TRIM29_ENST00000541857.1_Missense_Mutation_p.S273F	NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	540					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		ACCTTTCAGGGAGAAGGAGGA	0.602000													16	14					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135430955	135430955	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:135430955C>T	ENST00000394143.1	+	6	5381	c.5090C>T	c.(5089-5091)tCa>tTa	p.S1697L	GPR112_ENST00000287534.4_Missense_Mutation_p.S1634L|GPR112_ENST00000412101.1_Missense_Mutation_p.S1492L|GPR112_ENST00000394141.1_Missense_Mutation_p.S1492L|GPR112_ENST00000370652.1_Missense_Mutation_p.S1697L	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1697					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					ACCACATTTTCACCATTTCTA	0.448000													102	10					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	107012560	107012560	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:107012560C>T	ENST00000369701.3	+	23	3360	c.3133C>T	c.(3133-3135)Ctc>Ttc	p.L1045F		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1045						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGACCAGATCCTCATTGCCGT	0.527000													48	12					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4878583	4878583	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:4878583G>A	ENST00000354582.6	+	60	8459	c.8109G>A	c.(8107-8109)acG>acA	p.T2703T	ITPR1_ENST00000357086.4_Silent_p.T2670T|ITPR1_ENST00000544951.1_Silent_p.T681T|ITPR1_ENST00000456211.2_Silent_p.T2655T|ITPR1_ENST00000443694.2_Silent_p.T2703T|ITPR1_ENST00000302640.8_Silent_p.T2703T|ITPR1_ENST00000423119.2_Silent_p.T2670T|AC018816.3_ENST00000441894.1_Intron|AC018816.3_ENST00000449914.1_Intron|ITPR1_ENST00000463980.1_3'UTR			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2718					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding	p.T2703T(1)|p.T2670T(1)|p.T2655T(1)		NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AACTTGTCACGAACCTTTCTG	0.502000													11	21					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38903998	38903998	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:38903998C>T	ENST00000274276.3	+	8	1408	c.1006C>T	c.(1006-1008)Cct>Tct	p.P336S		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	336	Fibronectin type-III 1.				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					TTTAATGAATCCTTTTAGTGT	0.299000													8	25					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9066367	9066367	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:9066367C>T	ENST00000397910.4	-	3	21282	c.21079G>A	c.(21079-21081)Gaa>Aaa	p.E7027K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7029	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGGTCATTTCTGCTGATTCT	0.498000													98	136					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19396038	19396038	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:19396038G>A	ENST00000263208.5	-	3	435	c.179C>T	c.(178-180)cCc>cTc	p.P60L	HIRA_ENST00000464189.1_5'UTR|HIRA_ENST00000546308.1_Missense_Mutation_p.P16L|HIRA_ENST00000340170.4_Missense_Mutation_p.P60L|HIRA_ENST00000541063.1_Missense_Mutation_p.P16L	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	60					chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					AAGCATCTTGGGAATATTTTC	0.483000													47	34					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120599834	120599834	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:120599834G>A	ENST00000300648.6	-	21	2204	c.2192C>T	c.(2191-2193)tCc>tTc	p.S731F		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	731					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGACAGGACGGAAAGGGAGCC	0.617000													13	21					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110453598	110453598	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:110453598G>A	ENST00000378402.5	+	34	4298	c.4194G>A	c.(4192-4194)ggG>ggA	p.G1398G		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1398	IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CCAACAATGGGAAAGATTCAG	0.289000										HNSCC(38;0.096)			14	13					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117696239	117696239	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:117696239C>T	ENST00000317775.6	-	16	3179	c.2494G>A	c.(2494-2496)Gaa>Aaa	p.E832K	NOS1_ENST00000338101.4_Missense_Mutation_p.E832K|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	832	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TGCCTCATTTCCATCAAAGCA	0.498000													4	22					0	0	1	0	0
MMP16	4325	broad.mit.edu	37	8	89058988	89058988	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:89058988C>T	ENST00000286614.6	-	9	1679	c.1398G>A	c.(1396-1398)atG>atA	p.M466I		NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	466	Hemopexin-like 3.				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						CCATTGTTTTCATTTCTTCAC	0.368000													45	62					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69682021	69682021	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:69682021G>A	ENST00000265403.7	+	1	311	c.284G>A	c.(283-285)aGa>aAa	p.R95K	UGT2B10_ENST00000458688.2_Missense_Mutation_p.R95K	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	95					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						TTGGTTAAGAGATTGTCAGAA	0.308000													43	70					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150832782	150832782	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:150832782G>A	ENST00000370357.4	+	11	1278	c.1033G>A	c.(1033-1035)Gac>Aac	p.D345N		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	345						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					GGATCCAGAGGACTCAGTGGA	0.592000													38	2					0	0	1	0	0
PHKG1	5260	broad.mit.edu	37	7	56149894	56149894	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:56149894C>T	ENST00000452681.2	-	8	845	c.696G>A	c.(694-696)atG>atA	p.M232I	PHKG1_ENST00000537360.1_Missense_Mutation_p.M146I|PHKG1_ENST00000297373.2_Missense_Mutation_p.M200I	NM_001258459.1	NP_001245388.1	Q16816	PHKG1_HUMAN	phosphorylase kinase, gamma 1 (muscle)	200	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			endometrium(1)|large_intestine(1)|lung(5)	7	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GGTCCTCATTCATGGAGCACT	0.607000													40	69					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12125433	12125433	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:12125433T>C	ENST00000379388.2	+	4	5737	c.5405T>C	c.(5404-5406)gTt>gCt	p.V1802A		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1802					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GTGAGACAGGTTTGTACTACA	0.398000													50	166					0	0	1	0	0
RIT2	6014	broad.mit.edu	37	18	40503664	40503664	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:40503664G>A	ENST00000589109.1	-	4	470	c.299C>T	c.(298-300)tCc>tTc	p.S100F	RIT2_ENST00000590910.1_Missense_Mutation_p.P121S|RIT2_ENST00000326695.5_Missense_Mutation_p.S100F|RIT2_ENST00000282028.4_Missense_Mutation_p.S100F	NM_001272077.1	NP_001259006.1	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	100					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GTCAGTGACGGAGTAGCAGAT	0.478000													135	158					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43683098	43683098	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:43683098G>A	ENST00000599812.1	-	3	737	c.642C>T	c.(640-642)ccC>ccT	p.P214P	PSG5_ENST00000404580.1_Intron|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000342951.6_Intron|PSG5_ENST00000366175.3_Intron|PSG5_ENST00000407356.1_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	119	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				CACATTCATAGGGTCCTGCAA	0.502000													131	246					0	0	1	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42279460	42279460	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:42279460G>A	ENST00000399518.3	-	17	2431	c.1945C>T	c.(1945-1947)Cgg>Tgg	p.R649W	CTD-2382E5.1_ENST00000499478.2_RNA|PLA2G4E_ENST00000413860.2_Missense_Mutation_p.R620W	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	637	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		ACGAAGGACCGATGGGTAAGG	0.517000													36	8					0	0	1	0	0
GPR88	54112	broad.mit.edu	37	1	101004699	101004699	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:101004699C>T	ENST00000315033.4	+	2	616	c.177C>T	c.(175-177)ttC>ttT	p.F59F		NM_022049.2	NP_071332.2	Q9GZN0	GPR88_HUMAN	G protein-coupled receptor 88	59						integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|skin(1)	3		all_epithelial(167;1.19e-05)|all_lung(203;0.00159)|Lung NSC(277;0.00171)		Epithelial(280;0.0372)|all cancers(265;0.0558)|COAD - Colon adenocarcinoma(174;0.141)|Colorectal(144;0.156)|Lung(183;0.189)		TGTCGTCCTTCCGAAAGCTGC	0.682000													9	21					0	0	1	0	0
MPZL1	9019	broad.mit.edu	37	1	167742490	167742490	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:167742490C>T	ENST00000359523.2	+	4	692	c.490C>T	c.(490-492)Cca>Tca	p.P164S	MPZL1_ENST00000474859.1_Missense_Mutation_p.P164S|MPZL1_ENST00000392121.3_Intron	NM_003953.5|NM_024569.4	NP_003944.1|NP_078845.3	O95297	MPZL1_HUMAN	myelin protein zero-like 1	164					cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(2)	15	all_hematologic(923;0.215)					GCCTGTGTTTCCAGTTTGGGT	0.388000													59	83					0	0	1	0	0
SERTAD3	29946	broad.mit.edu	37	19	40947745	40947745	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:40947745G>A	ENST00000322354.3	-	2	739	c.243C>T	c.(241-243)ccC>ccT	p.P81P	SERTAD3_ENST00000392028.4_Silent_p.P81P	NM_203344.2	NP_976219.1	Q9UJW9	SRTD3_HUMAN	SERTA domain containing 3	81					negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			kidney(1)|large_intestine(4)|lung(2)	7			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCAGGAAGAGGGGCTCGGGGG	0.642000													31	29					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35823575	35823575	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:35823575G>A	ENST00000085219.5	+	3	226	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	CD22_ENST00000595419.1_3'UTR|CD22_ENST00000536635.2_Missense_Mutation_p.E54K|CD22_ENST00000270311.6_5'UTR|CD22_ENST00000419549.2_5'UTR|CD22_ENST00000341773.6_Missense_Mutation_p.E54K|CD22_ENST00000544992.2_Missense_Mutation_p.E54K|CD22_ENST00000594250.1_Missense_Mutation_p.E54K	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	54	Ig-like V-type.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	TGGTGACCTGGAAAGCTTCAT	0.507000													48	55					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124402732	124402732	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:124402732C>T	ENST00000368909.3	+	53	7166	c.7060C>T	c.(7060-7062)Ccc>Tcc	p.P2354S	DMBT1_ENST00000368955.3_Missense_Mutation_p.P2344S|DMBT1_ENST00000359586.6_Missense_Mutation_p.P1074S|DMBT1_ENST00000330163.4_Missense_Mutation_p.P1726S|DMBT1_ENST00000368956.2_Missense_Mutation_p.P1726S|DMBT1_ENST00000344338.3_Missense_Mutation_p.P2344S|DMBT1_ENST00000338354.3_Missense_Mutation_p.P2354S	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2354	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GAACCGCTTCCCCTCCGTGTA	0.587000													52	9					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220156203	220156203	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:220156203G>A	ENST00000295718.2	-	20	2958	c.2718C>T	c.(2716-2718)atC>atT	p.I906I	PTPRN_ENST00000423636.2_Silent_p.I816I|PTPRN_ENST00000409251.3_Silent_p.I877I|PTPRN_ENST00000497977.1_5'UTR	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	906	Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		TGCAGTGCACGATGATGGGGC	0.597000													24	53					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179729488	179729488	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:179729488C>T	ENST00000253778.8	-	18	2108	c.1939G>A	c.(1939-1941)Ggc>Agc	p.G647S		NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	647	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	CTCAGGATGCCCTGGAGGCAG	0.532000													51	39					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101549045	101549045	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:101549045C>T	ENST00000284395.5	+	8	1157	c.757C>T	c.(757-759)Ctc>Ttc	p.L253F	LRRK1_ENST00000388948.3_Missense_Mutation_p.L256F			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	256					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CCACCAGGCTCTCCGTGTGAA	0.532000											OREG0023521	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	31					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169644879	169644879	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:169644879G>A	ENST00000428432.2	+	6	1218	c.829G>A	c.(829-831)Gat>Aat	p.D277N	SAMD7_ENST00000335556.3_Missense_Mutation_p.D277N	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	277										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GGCCTGGGACGATGGGAAAGA	0.567000													35	56					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89480345	89480345	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:89480345C>T	ENST00000336596.2	+	13	2407	c.2182C>T	c.(2182-2184)Cga>Tga	p.R728*	EPHA3_ENST00000494014.1_Nonsense_Mutation_p.R728*	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	728	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GGGGATGCTTCGAGGGATAGC	0.433000										TSP Lung(6;0.00050)			29	33					0	0	1	0	0
TPRG1	285386	broad.mit.edu	37	3	188925281	188925281	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:188925281G>A	ENST00000345063.3	+	2	275	c.108G>A	c.(106-108)ccG>ccA	p.P36P	TPRG1_ENST00000433971.1_Silent_p.P36P	NM_198485.3	NP_940887.1	Q6ZUI0	TPRG1_HUMAN	tumor protein p63 regulated 1	36								p.P36P(1)		endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|skin(2)|urinary_tract(1)	16	all_cancers(143;6.12e-12)|all_hematologic(3;0.0359)|Ovarian(172;0.0925)	all_lung(153;8.23e-09)|Lung NSC(153;3.55e-06)|all_neural(597;0.0019)|Myeloproliferative disorder(1037;0.0255)	Lung(62;6.93e-06)	GBM - Glioblastoma multiforme(93;4.77e-14)		AAGAGGACCCGATGCCAAGAC	0.478000													60	57					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7981752	7981752	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:7981752G>A	ENST00000328600.2	-	2	1568	c.1407C>T	c.(1405-1407)ttC>ttT	p.F469F		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	469	NACHT.						ATP binding	p.F469F(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AAAAGTCCTGGAAGCTGATGT	0.512000													66	81					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54735297	54735297	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:54735297G>A	ENST00000306858.7	+	2	369	c.253G>A	c.(253-255)Gat>Aat	p.D85N		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	85										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TTCCTGTGATGATACCTTATC	0.433000													62	77					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47913603	47913603	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:47913603C>T	ENST00000289672.2	-	24	3840	c.3790G>A	c.(3790-3792)Gtt>Att	p.V1264I		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1264	REJ.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TCAGTGGAAACCATGACTGTG	0.512000													17	11					0	0	1	0	0
KLF3	51274	broad.mit.edu	37	4	38696384	38696384	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:38696384T>C	ENST00000261438.5	+	5	1018	c.713T>C	c.(712-714)aTc>aCc	p.I238T		NM_016531.5	NP_057615.3	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	238	Pro-rich.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(5)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18						CCTTCGGTCATCGTGCAGCCT	0.463000													75	81					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34125558	34125558	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:34125558C>T	ENST00000297161.2	+	14	1973	c.1599C>T	c.(1597-1599)ttC>ttT	p.F533F	BMPER_ENST00000426693.1_Silent_p.F533F	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	533	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						CCAATGAGTTCTGCAACAGAC	0.473000													38	56					0	0	1	0	0
PYGM	5837	broad.mit.edu	37	11	64514754	64514754	+	Missense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:64514754A>T	ENST00000164139.3	-	18	2652	c.2254T>A	c.(2254-2256)Tcc>Acc	p.S752T	PYGM_ENST00000377432.3_Missense_Mutation_p.S664T	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	752					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	TGTTTGGGGGAGAAGAAGCCA	0.577000													43	64					0	0	1	0	0
IDO1	3620	broad.mit.edu	37	8	39780114	39780114	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:39780114A>G	ENST00000518237.1	+	6	1120	c.481A>G	c.(481-483)Aaa>Gaa	p.K161E	IDO1_ENST00000522495.1_Missense_Mutation_p.K161E|RP11-44K6.3_ENST00000517623.1_RNA	NM_002164.5	NP_002155.1	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	161					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(2)	12					L-Tryptophan(DB00150)	AGACTGCAGTAAAGGATTCTT	0.368000													38	9					0	0	1	0	0
CSHL1	1444	broad.mit.edu	37	17	61988214	61988214	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:61988214G>A	ENST00000392824.4	-	2	142	c.81C>T	c.(79-81)gtC>gtT	p.V27V	CSHL1_ENST00000309894.5_Silent_p.V27V|CSHL1_ENST00000561003.1_Intron|CSHL1_ENST00000450719.3_Intron|CSHL1_ENST00000558099.1_5'UTR|CSHL1_ENST00000259003.10_Intron|CSHL1_ENST00000438387.2_Intron|CSHL1_ENST00000346606.6_Intron			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	27						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						GAACGGTTTGGACGGCACCAG	0.582000													55	79					0	0	1	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545374	234545374	+	Missense_Mutation	SNP	C	C	T	rs146289100	byFrequency	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:234545374C>T	ENST00000344644.5	+	1	275	c.206C>T	c.(205-207)tCa>tTa	p.S69L	UGT1A10_ENST00000373445.1_Missense_Mutation_p.S69L|UGT1A8_ENST00000373450.4_Intron	NM_019075.2	NP_061948.1														endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		CTGGAAAGATCACTGAATTGC	0.498000													138	90					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27680737	27680737	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:27680737G>A	ENST00000260570.3	-	28	3185	c.3082C>T	c.(3082-3084)Ctc>Ttc	p.L1028F		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	1028					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					GTATCACTGAGGAGATCTGGA	0.517000													36	42					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118353182	118353182	+	Missense_Mutation	SNP	T	T	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:118353182T>G	ENST00000534358.1	+	8	4081	c.4058T>G	c.(4057-4059)aTc>aGc	p.I1353S	KMT2A_ENST00000389506.5_Missense_Mutation_p.I1353S|KMT2A_ENST00000354520.4_Missense_Mutation_p.I1353S|KMT2A_ENST00000420751.2_Intron	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		CGCCCAAGTATCCCTGTAAAA	0.403000													11	80					0	0	1	0	0
PTH1R	5745	broad.mit.edu	37	3	46944016	46944016	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:46944016G>A	ENST00000449590.1	+	14	1415	c.1211_splice	c.e14-1	p.R404_splice	PTH1R_ENST00000418619.1_Splice_Site_p.R404_splice|PTH1R_ENST00000430002.2_Splice_Site_p.R404_splice|PTH1R_ENST00000313049.5_Splice_Site_p.R404_splice	NM_000316.2	NP_000307.1	Q03431	PTH1R_HUMAN	parathyroid hormone 1 receptor	404						cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(2)|stomach(1)|urinary_tract(2)	19						GCTGGCCCAGGAAGCTGCTCA	0.617000													15	21					0	0	1	0	0
WDR7	23335	broad.mit.edu	37	18	54363643	54363643	+	Missense_Mutation	SNP	G	G	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:54363643G>T	ENST00000254442.3	+	12	1739	c.1528G>T	c.(1528-1530)Gtt>Ttt	p.V510F	WDR7_ENST00000589935.1_Intron|WDR7_ENST00000357574.3_Missense_Mutation_p.V510F	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	510										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		TATCTTCTGTGTTCATGGTGG	0.353000													38	17					3.09479e-21	3.13108e-21	1	1	0
GRIA1	2890	broad.mit.edu	37	5	153175112	153175112	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:153175112G>A	ENST00000340592.5	+	14	2420	c.2347G>A	c.(2347-2349)Gat>Aat	p.D783N	GRIA1_ENST00000285900.5_Intron|GRIA1_ENST00000521843.2_Intron|GRIA1_ENST00000518142.1_Intron|GRIA1_ENST00000518783.1_Intron|GRIA1_ENST00000448073.4_Missense_Mutation_p.D793N	NM_001114183.1|NM_001258020.1	NP_001107655.1|NP_001244949.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	783					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	ATGGTGGTACGATAAAGGGGA	0.483000													16	14					0	0	1	0	0
CDHR5	53841	broad.mit.edu	37	11	621829	621829	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:621829C>T	ENST00000358353.3	-	5	710	c.388G>A	c.(388-390)Gag>Aag	p.E130K	CDHR5_ENST00000397542.2_Missense_Mutation_p.E130K|CDHR5_ENST00000349570.7_Missense_Mutation_p.E130K			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	130	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						ACCCTTATCTCCTTGGTCTTA	0.642000													29	58					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142881181	142881181	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:142881181T>C	ENST00000446620.1	+	1	670	c.670T>C	c.(670-672)Ttc>Ctc	p.F224L		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	224					sensory perception of taste	integral to membrane	G-protein coupled receptor activity	p.F224L(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					TCTGATCATGTTCATCCTGAC	0.507000													54	62					0	0	1	0	0
REST	5978	broad.mit.edu	37	4	57798003	57798003	+	Silent	SNP	T	T	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:57798003T>G	ENST00000309042.7	+	4	3293	c.2979T>G	c.(2977-2979)ccT>ccG	p.P993P		NM_001193508.1|NM_005612.4	NP_001180437.1|NP_005603.3	Q13127	REST_HUMAN	RE1-silencing transcription factor	993					cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	50	Glioma(25;0.08)|all_neural(26;0.181)					TGGCATCACCTCCTGCTACAA	0.458000													29	33					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424775	125424775	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:125424775C>T	ENST00000373686.1	+	1	931	c.931C>T	c.(931-933)Cag>Tag	p.Q311*				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						TCTCTATTTTCAGCCCCTGTC	0.413000													131	19					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810580	65810580	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:65810580C>T	ENST00000312006.4	-	3	975	c.694G>A	c.(694-696)Gag>Aag	p.E232K	GAL3ST3_ENST00000527878.1_Missense_Mutation_p.E232K	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	232					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						AAAACCTCCTCCACCTGGCGG	0.662000													42	48					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31287013	31287013	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:31287013G>A	ENST00000544665.3	+	9	1073	c.1002G>A	c.(1000-1002)gcG>gcA	p.A334A	ITGAM_ENST00000287497.8_Silent_p.A334A	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	334					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						AGATCTTTGCGATCGAGGGTG	0.542000													24	19					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21793427	21793427	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:21793427G>A	ENST00000206660.6	+	15	2252	c.2252G>A	c.(2251-2253)tGg>tAg	p.W751*	RPGRIP1_ENST00000307974.4_Nonsense_Mutation_p.W110*|RPGRIP1_ENST00000553500.1_3'UTR|RPGRIP1_ENST00000382933.4_Intron|RPGRIP1_ENST00000400017.2_Nonsense_Mutation_p.W751*|RPGRIP1_ENST00000557771.1_Nonsense_Mutation_p.W713*|RPGRIP1_ENST00000556336.1_Intron			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	751					response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CTAGAGTACTGGATGAGGCTG	0.522000													20	9					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34191094	34191094	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:34191094C>T	ENST00000373381.4	-	17	2727	c.2551G>A	c.(2551-2553)Ggg>Agg	p.G851R		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	811	CUB 5.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TAAGTCCGCCCATCGCGTACT	0.493000													26	33					0	0	1	0	0
OR51B6	390058	broad.mit.edu	37	11	5373581	5373581	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:5373581C>T	ENST00000380219.1	+	1	844	c.844C>T	c.(844-846)Cca>Tca	p.P282S	HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron	NM_001004750.1	NP_001004750.1	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B, member 6	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	21		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTCCTTTTCCCACCTTTTAT	0.388000													58	85					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50657167	50657167	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:50657167G>A	ENST00000248846.5	-	21	4890	c.4786C>T	c.(4786-4788)Ccg>Tcg	p.P1596S	TUBGCP6_ENST00000491449.1_5'UTR|TUBGCP6_ENST00000439308.2_3'UTR			Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1596					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGCACATCCGGGGCGTTGGGG	0.677000													22	55					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32193847	32193847	+	Missense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:32193847A>T	ENST00000373658.3	-	31	4792	c.4451T>A	c.(4450-4452)cTc>cAc	p.L1484H	BAI2_ENST00000527361.1_Missense_Mutation_p.L1450H|BAI2_ENST00000398538.1_Missense_Mutation_p.L1472H|BAI2_ENST00000465256.1_5'UTR|BAI2_ENST00000398542.1_Missense_Mutation_p.L1384H|BAI2_ENST00000398547.1_Missense_Mutation_p.L1417H|BAI2_ENST00000398556.3_Missense_Mutation_p.L1399H|BAI2_ENST00000257070.4_Missense_Mutation_p.L1450H|BAI2_ENST00000373655.2_Missense_Mutation_p.L1483H|BAI2_ENST00000440175.2_Missense_Mutation_p.L1093H	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	1484					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		CTCGTGGTAGAGTTCTGAATG	0.642000													34	37					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150697629	150697629	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:150697629C>T	ENST00000297494.3	+	10	1532	c.1175C>T	c.(1174-1176)tCc>tTc	p.S392F	NOS3_ENST00000461406.1_Missense_Mutation_p.S186F|NOS3_ENST00000467517.1_Missense_Mutation_p.S392F|NOS3_ENST00000484524.1_Missense_Mutation_p.S392F	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	392	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	ACCACCTCGTCCCTGTGGAAA	0.602000													37	49					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50084407	50084407	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:50084407G>A	ENST00000281631.5	+	10	879	c.721G>A	c.(721-723)Gga>Aga	p.G241R	PARP8_ENST00000505697.2_Missense_Mutation_p.G241R|PARP8_ENST00000503750.2_Missense_Mutation_p.G241R|PARP8_ENST00000505554.1_Missense_Mutation_p.G220R|PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000514067.2_Missense_Mutation_p.G241R|PARP8_ENST00000514342.2_5'UTR	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	241						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				ATTTGGATTGGGACATCAGCT	0.343000													8	17					0	0	1	0	0
C9orf129	445577	broad.mit.edu	37	9	96081391	96081391	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:96081391C>T	ENST00000375419.1	-	4	794	c.431G>A	c.(430-432)aGg>aAg	p.R144K	WNK2_ENST00000395475.2_Intron|WNK2_ENST00000349097.3_Intron|WNK2_ENST00000356055.3_Intron|WNK2_ENST00000395477.2_Intron|WNK2_ENST00000471076.1_Intron	NM_001098808.1	NP_001092278.1	Q5T035	CI129_HUMAN	chromosome 9 open reading frame 129	144										endometrium(2)|large_intestine(1)|lung(1)|ovary(2)	6						ACCTGTCCCCCTTGCCTGTGA	0.512000													61	6					0	0	1	0	0
GRXCR2	643226	broad.mit.edu	37	5	145252487	145252487	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:145252487T>C	ENST00000377976.1	-	1	44	c.45A>G	c.(43-45)aaA>aaG	p.K15K		NM_001080516.1	NP_001073985.1	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	15										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						CTTTCCGGGGTTTGCCATCAC	0.502000													27	82					0	0	1	0	0
LRRC18	474354	broad.mit.edu	37	10	50121703	50121703	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:50121703G>A	ENST00000374160.3	-	1	574	c.498C>T	c.(496-498)ctC>ctT	p.L166L	WDFY4_ENST00000325239.5_Intron|LRRC18_ENST00000298124.3_Silent_p.L166L|WDFY4_ENST00000413659.2_Intron|RP11-523O18.7_ENST00000430438.1_RNA	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	166						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						TCAGCTTGGGGAGCTTGGAGA	0.537000													20	3					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174541	150174541	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:150174541G>A	ENST00000307271.3	+	5	2245	c.1671G>A	c.(1669-1671)acG>acA	p.T557T		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	557						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CAGACTTTACGAAATACGCGA	0.493000													53	75					0	0	1	0	0
NOTCH2NL	388677	broad.mit.edu	37	1	145290442	145290442	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:145290442C>T	ENST00000344859.3	+	5	1010	c.648C>T	c.(646-648)atC>atT	p.I216I	NBPF10_ENST00000369339.2_5'UTR|RP11-458D21.5_ENST00000468030.1_Intron|NOTCH2NL_ENST00000479995.2_3'UTR			Q7Z3S9	NT2NL_HUMAN	notch 2 N-terminal like	0	EGF-like 6.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	27						CATGGCCAATCTTTCCTAAGC	0.368000													17	323					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77542398	77542398	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:77542398G>A	ENST00000461745.1	+	5	1571	c.671G>A	c.(670-672)cGa>cAa	p.R224Q	ROBO2_ENST00000332191.8_Missense_Mutation_p.R224Q|ROBO2_ENST00000487694.3_Missense_Mutation_p.R240Q	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	224					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding	p.R224Q(1)		NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TTTCAAGAACGACCCACATTT	0.363000													27	49					0	0	1	0	0
CENPK	64105	broad.mit.edu	37	5	64838670	64838670	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:64838670G>A	ENST00000396679.1	-	6	461	c.247C>T	c.(247-249)Ccc>Tcc	p.P83S	CENPK_ENST00000510693.1_Missense_Mutation_p.P53S|CENPK_ENST00000508421.1_Missense_Mutation_p.P53S|CENPK_ENST00000506282.2_5'UTR|CENPK_ENST00000242872.3_Missense_Mutation_p.P83S|CENPK_ENST00000514814.1_Missense_Mutation_p.P83S	NM_022145.4	NP_071428.2	Q9BS16	CENPK_HUMAN	centromere protein K	83					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm				breast(1)|endometrium(1)|large_intestine(3)|lung(5)	10		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00466)		TCAGTCAAGGGAATTGCTACA	0.299000													32	19					0	0	1	0	0
FANCI	55215	broad.mit.edu	37	15	89837175	89837175	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:89837175T>C	ENST00000310775.7	+	23	2489	c.2403T>C	c.(2401-2403)agT>agC	p.S801S	FANCI_ENST00000300027.8_Silent_p.S801S	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	801					cell cycle|DNA repair	nucleoplasm	protein binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					ACAAGACAAGTGATAGTCTTT	0.398000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				34	77					0	0	1	0	0
STAR	6770	broad.mit.edu	37	8	38003836	38003836	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:38003836C>T	ENST00000276449.4	-	4	882	c.436G>A	c.(436-438)Gag>Aag	p.E146K		NM_000349.2	NP_000340.2	P49675	STAR_HUMAN	steroidogenic acute regulatory protein	146	START.				C21-steroid hormone biosynthetic process	mitochondrial intermembrane space	cholesterol transporter activity			breast(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	11	Colorectal(12;0.000442)	all_lung(54;0.0151)|Lung NSC(58;0.0295)		READ - Rectum adenocarcinoma(644;0.188)		GGGTTCCACTCCCCCATTGCT	0.587000													54	8					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11190804	11190804	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:11190804C>T	ENST00000361445.4	-	39	5471	c.5395G>A	c.(5395-5397)Gaa>Aaa	p.E1799K	MTOR_ENST00000376838.1_Missense_Mutation_p.E4K	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1799	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity	p.E1799K(4)		breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						AGCACAGCTTCGAAGTTCATC	0.582000													8	11					0	0	1	0	0
BACH2	60468	broad.mit.edu	37	6	90642326	90642326	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:90642326G>A	ENST00000257749.4	-	9	3034	c.2327C>T	c.(2326-2328)cCc>cTc	p.P776L	BACH2_ENST00000537989.1_Missense_Mutation_p.P776L|BACH2_ENST00000343122.3_Missense_Mutation_p.P776L	NM_021813.2	NP_068585.1	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 2	776						nucleus	protein dimerization activity|sequence-specific DNA binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	45		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		GGGTCCGGGGGGAGCCGCGCC	0.627000													46	58					0	0	1	0	0
RSF1	51773	broad.mit.edu	37	11	77404608	77404608	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:77404608G>A	ENST00000308488.6	-	8	3066	c.2764C>T	c.(2764-2766)Cgc>Tgc	p.R922C	RSF1_ENST00000360355.2_Missense_Mutation_p.R891C|RSF1_ENST00000480887.1_Missense_Mutation_p.R670C			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	922					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			AGAGGAGGGCGAAGGCAGGCA	0.443000													13	21					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21627600	21627600	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:21627600T>C	ENST00000425654.2	+	19	2947	c.2467T>C	c.(2467-2469)Ttc>Ctc	p.F823L	CNKSR2_ENST00000543067.1_Missense_Mutation_p.F804L|CNKSR2_ENST00000279451.4_Missense_Mutation_p.F853L|CNKSR2_ENST00000379510.3_Missense_Mutation_p.F853L	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	853					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						AGATAGCGGGTTCAACCATTG	0.542000													58	7					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107432324	107432324	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:107432324G>A	ENST00000340010.5	-	4	517	c.333C>T	c.(331-333)ttC>ttT	p.F111F	SLC26A3_ENST00000422236.2_Silent_p.F76F	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	111					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TTATGGCTGGGAAAAAGGATG	0.443000													45	55					0	0	1	0	0
VPS4A	27183	broad.mit.edu	37	16	69352604	69352604	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:69352604A>G	ENST00000254950.11	+	4	489	c.333A>G	c.(331-333)gaA>gaG	p.E111E	RP11-343C2.3_ENST00000570054.2_Silent_p.E135E|VPS4A_ENST00000569775.1_Intron	NM_013245.2	NP_037377.1	Q9UN37	VPS4A_HUMAN	vacuolar protein sorting 4 homolog A (S. cerevisiae)	111					cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(3)	7		Ovarian(137;0.101)				AACTGCAAGAACAGCTGATGG	0.622000													19	23					0	0	1	0	0
PTPN21	11099	broad.mit.edu	37	14	88946333	88946333	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:88946333T>C	ENST00000556564.1	-	13	1726	c.1442A>G	c.(1441-1443)tAc>tGc	p.Y481C	PTPN21_ENST00000328736.3_Missense_Mutation_p.Y481C	NM_007039.3	NP_008970.2	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type 21	481						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|liver(1)|lung(7)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						GCTGTAGGCGTACGAGCTGCC	0.657000													17	41					0	0	1	0	0
PHKB	5257	broad.mit.edu	37	16	47627449	47627449	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:47627449C>T	ENST00000455779.1	+	12	1271	c.1086C>T	c.(1084-1086)ttC>ttT	p.F362F	PHKB_ENST00000299167.8_Silent_p.F369F|PHKB_ENST00000566044.1_Silent_p.F362F|PHKB_ENST00000323584.5_Silent_p.F369F			Q93100	KPBB_HUMAN	phosphorylase kinase, beta	369					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|liver(1)|lung(18)|ovary(1)|skin(1)	41		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				CCATATTTTTCCTTTATATGA	0.254000													15	25					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	14012	14012	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrM:14012A>G	ENST00000361567.2	+	1	1676	c.1676A>G	c.(1675-1677)gAa>gGa	p.E559G				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	559					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	AACCTGACTAGAAAAGCTATT	0.443000													82	69					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	169099271	169099271	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:169099271C>T	ENST00000494292.1	-	2	176	c.79G>A	c.(79-81)Gaa>Aaa	p.E27K	MECOM_ENST00000485957.1_5'UTR	NM_004991.3	NP_004982.2	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	27							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GGCATTTCTTCCAAAGGTATT	0.418000													14	15					0	0	1	0	0
ACSM4	341392	broad.mit.edu	37	12	7470723	7470723	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:7470723G>A	ENST00000399422.4	+	5	914	c.866G>A	c.(865-867)gGa>gAa	p.G289E		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	289					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						TGGCTGTGTGGAGCCTGTGTT	0.473000													47	27					0	0	1	0	0
GRK6	2870	broad.mit.edu	37	5	176862086	176862086	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:176862086A>G	ENST00000355472.5	+	11	1189	c.1021A>G	c.(1021-1023)Acc>Gcc	p.T341A	GRK6_ENST00000507633.1_Missense_Mutation_p.T341A|GRK6_ENST00000355958.5_Missense_Mutation_p.T341A|GRK6_ENST00000393576.3_Missense_Mutation_p.T307A|GRK6_ENST00000528793.1_Missense_Mutation_p.T341A	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	341	Protein kinase.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGAGGGCCAGACCATCAAAGG	0.622000													29	19					0	0	1	0	0
CAMK2A	815	broad.mit.edu	37	5	149602638	149602638	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:149602638C>T	ENST00000348628.6	-	17	2012	c.1347G>A	c.(1345-1347)tcG>tcA	p.S449S	CAMK2A_ENST00000398376.3_Silent_p.S460S|CAMK2A_ENST00000351010.6_5'UTR	NM_015981.3|NM_171825.2	NP_057065.2|NP_741960.1	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II alpha	449					interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)	15		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGTCTCCTCCGACTGGGCGG	0.647000													21	61					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26085919	26085919	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:26085919G>A	ENST00000313735.6	-	26	3575	c.3342C>T	c.(3340-3342)ttC>ttT	p.F1114F		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	1114					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	TGAGCTGAAAGAAATAGTCCT	0.612000													9	18					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63176292	63176292	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:63176292C>T	ENST00000279178.3	+	9	1791	c.1542C>T	c.(1540-1542)ctC>ctT	p.L514L	SLC22A9_ENST00000310969.4_3'UTR	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	514					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						TTGCTTTCCTCCTCCTTCCTG	0.517000													46	63					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34148365	34148365	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:34148365C>T	ENST00000346193.3	-	1	2082	c.2031G>A	c.(2029-2031)agG>agA	p.R677R		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	677										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						TGTGGAATTTCCTGCCCCAGT	0.433000													67	6					0	0	1	0	0
OR1N2	138882	broad.mit.edu	37	9	125315495	125315495	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:125315495G>A	ENST00000373688.2	+	1	105	c.47G>A	c.(46-48)gGa>gAa	p.G16E		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						CAAGGGATGGGAAAACCAGGC	0.448000													75	12					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106768868	106768868	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:106768868G>A	ENST00000276185.4	+	2	78	c.78G>A	c.(76-78)caG>caA	p.Q26Q	FRMPD3-AS1_ENST00000415252.1_RNA			Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	26						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						CTGGCCAACAGGAACTCTTTT	0.463000													39	1					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10411879	10411879	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:10411879G>A	ENST00000226207.5	-	16	1792	c.1698C>T	c.(1696-1698)ttC>ttT	p.F566F	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	566	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TGGGCTTCTGGAAGTTATTGG	0.502000													54	66					0	0	1	0	0
AGAP1	116987	broad.mit.edu	37	2	236715901	236715901	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:236715901C>T	ENST00000409538.1	+	9	2267	c.1771C>T	c.(1771-1773)Cca>Tca	p.P591S	AGAP1_ENST00000336665.5_Missense_Mutation_p.P326S|AGAP1_ENST00000428334.2_Missense_Mutation_p.P165S|AGAP1_ENST00000304032.7_Missense_Mutation_p.P326S|AGAP1_ENST00000409457.1_Missense_Mutation_p.P326S			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	326					protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						AGGGAGCGACCCAGACAAAGA	0.567000													102	87					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29408446	29408446	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:29408446G>A	ENST00000444197.2	+	1	1364	c.654G>A	c.(652-654)ggG>ggA	p.G218G	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	218					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						GCTCCTACGGGCGTATCCTCG	0.577000													126	169					0	0	1	0	0
ZSCAN5A	79149	broad.mit.edu	37	19	56736206	56736206	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:56736206A>G	ENST00000587340.1	-	4	905	c.210T>C	c.(208-210)caT>caC	p.H70H	ZSCAN5A_ENST00000587492.1_Intron|ZSCAN5A_ENST00000254165.3_Intron|ZSCAN5A_ENST00000592355.1_Silent_p.H70H|ZSCAN5A_ENST00000391713.1_Silent_p.H70H			Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	70	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						TCAGCCACAGATGGCACAGCT	0.567000													19	38					0	0	1	0	0
OTUD4	54726	broad.mit.edu	37	4	146065533	146065533	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:146065533T>C	ENST00000454497.2	-	15	1418	c.1281A>G	c.(1279-1281)agA>agG	p.R427R	OTUD4_ENST00000455611.2_5'UTR|OTUD4_ENST00000447906.2_Silent_p.R492R	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	491							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					GTGATGATTTTCTCTGGACAC	0.383000													107	117					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66461281	66461281	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:66461281C>T	ENST00000533211.1	-	23	4886	c.4555G>A	c.(4555-4557)Gac>Aac	p.D1519N	SPTBN2_ENST00000529997.1_Missense_Mutation_p.D1519N|SPTBN2_ENST00000309996.2_Missense_Mutation_p.D1519N			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1519					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						CTGGGCAGGTCCTTGCCATGC	0.592000													14	26					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23527584	23527584	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:23527584G>A	ENST00000296682.3	+	11	2569	c.2387G>A	c.(2386-2388)aGg>aAg	p.R796K		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	796					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGTCACCAGAGGACACACACA	0.572000										HNSCC(3;0.000094)			90	23					0	0	1	0	0
RLF	6018	broad.mit.edu	37	1	40656453	40656453	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:40656453C>T	ENST00000372771.4	+	3	429	c.402C>T	c.(400-402)ttC>ttT	p.F134F		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	134					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			GGAGTTGTTTCGAATTACTGC	0.323000													29	30					0	0	1	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276890	71276890	+	Missense_Mutation	SNP	C	C	T	rs36179995		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:71276890C>T	ENST00000398531.1	+	1	282	c.257C>T	c.(256-258)tCc>tTc	p.S86F	KRTAP5-10_ENST00000376536.4_Intron	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	86	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						GGCTGTGGTTCCTGTGGGGGC	0.687000													52	81					0	0	1	0	0
BMP3	651	broad.mit.edu	37	4	81974625	81974625	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:81974625G>A	ENST00000282701.2	+	3	1674	c.1354G>A	c.(1354-1356)Gaa>Aaa	p.E452K		NM_001201.2	NP_001192.2	P12645	BMP3_HUMAN	bone morphogenetic protein 3	452					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	29						ATTCTTTGATGAAAATAAGAA	0.408000													55	90					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21188850	21188850	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:21188850C>T	ENST00000255882.6	-	3	453	c.367_splice	c.e3+1	p.G123_splice	PI4KA_ENST00000572273.1_Splice_Site_p.G65_splice	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	65					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			ATACAATTACCTCTGCCTTTC	0.373000													74	154					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65267689	65267689	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:65267689G>A	ENST00000534336.1	+	0	2457					NR_002819.2																						GCTTTTGGAAGAGTTAGAAGA	0.333000													19	11					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51329169	51329169	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:51329169G>A	ENST00000326856.4	-	6	780	c.651C>T	c.(649-651)atC>atT	p.I217I	KLK15_ENST00000598239.1_Silent_p.I218I|KLK15_ENST00000416184.1_Silent_p.I133I|KLK15_ENST00000301421.2_3'UTR|KLK15_ENST00000596931.1_3'UTR	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	218	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		TGCCCTGCAGGATGCCCCCAC	0.557000													29	24					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242142881	242142881	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:242142881G>A	ENST00000274979.8	+	9	1122	c.1019G>A	c.(1018-1020)gGg>gAg	p.G340E	ANO7_ENST00000402430.3_Missense_Mutation_p.G339E	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	340						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						AGGTACTTCGGGGAGAAGGTG	0.647000													5	8					0	0	1	0	0
KRTAP5-1	387264	broad.mit.edu	37	11	1606190	1606190	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:1606190C>T	ENST00000382171.2	-	1	323	c.290G>A	c.(289-291)gGg>gAg	p.G97E	KRTAP5-AS1_ENST00000534077.1_RNA|KRTAP5-AS1_ENST00000532922.1_RNA|KRTAP5-AS1_ENST00000524947.1_RNA|KRTAP5-AS1_ENST00000424148.1_RNA	NM_001005922.1	NP_001005922.1	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	97	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(3)|kidney(1)|lung(9)|skin(2)|upper_aerodigestive_tract(1)	16		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCCACAACCCCCCTTGGATCC	0.677000													53	40					0	0	1	0	0
ETV7	51513	broad.mit.edu	37	6	36334429	36334429	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:36334429G>A	ENST00000373738.1	-	7	1699	c.854C>T	c.(853-855)tCt>tTt	p.S285F	ETV7_ENST00000373737.4_Missense_Mutation_p.S263F|ETV7_ENST00000340181.4_Missense_Mutation_p.S340F|ETV7_ENST00000339796.5_Intron|ETV7_ENST00000538992.1_Missense_Mutation_p.S189F	NM_001207036.1	NP_001193965.1	Q9Y603	ETV7_HUMAN	ets variant 7	340					organ morphogenesis|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|skin(4)	10						CCCTCACGGAGAGATTTCTGG	0.612000													35	126					0	0	1	0	0
AFP	174	broad.mit.edu	37	4	74315155	74315155	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:74315155G>A	ENST00000395792.2	+	9	1262	c.1162G>A	c.(1162-1164)Gaa>Aaa	p.E388K	AFP_ENST00000226359.2_Missense_Mutation_p.E388K	NM_001134.1	NP_001125.1	P02771	FETA_HUMAN	alpha-fetoprotein	388	Albumin 2.				transport		metal ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|urinary_tract(1)	22	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTTCCAGACTGAAAACCCTCT	0.368000									Alpha-Fetoprotein, Hereditary Persistence of				32	44					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63966673	63966673	+	Missense_Mutation	SNP	T	T	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:63966673T>G	ENST00000443617.2	-	38	7801	c.7714A>C	c.(7714-7716)Aag>Cag	p.K2572Q		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	2572					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						ACTGCTCGCTTCACCATGTGT	0.493000													17	29					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7608228	7608228	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:7608228G>A	ENST00000256861.6	-	13	2370	c.2292C>T	c.(2290-2292)atC>atT	p.I764I	ITIH5_ENST00000397146.2_Intron|ITIH5_ENST00000298441.6_Silent_p.I550I|ITIH5_ENST00000446830.2_Silent_p.I546I	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	764					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						CACCATCCAAGATGACTCTGC	0.562000													16	4					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29101160	29101160	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:29101160C>T	ENST00000261590.8	+	5	686	c.477C>T	c.(475-477)ttC>ttT	p.F159F	DSG2_ENST00000585206.1_Silent_p.F159F	NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	159	Cadherin 1.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AACCAGTGTTCACACAGGATG	0.368000													38	55					0	0	1	0	0
RFX1	5989	broad.mit.edu	37	19	14077481	14077481	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:14077481G>A	ENST00000254325.4	-	13	2049	c.1815C>T	c.(1813-1815)atC>atT	p.I605I		NM_002918.4	NP_002909.4	P22670	RFX1_HUMAN	regulatory factor X, 1 (influences HLA class II expression)	605					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			GGAAGGCTTTGATGTCCCCGG	0.677000													59	57					0	0	1	0	0
WISP1	8840	broad.mit.edu	37	8	134232939	134232939	+	Silent	SNP	A	A	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:134232939A>C	ENST00000250160.6	+	3	571	c.465A>C	c.(463-465)ccA>ccC	p.P155P	WISP1_ENST00000517423.1_Intron|WISP1_ENST00000519433.1_Intron|WISP1_ENST00000220856.6_Intron|WISP1_ENST00000377863.2_Intron	NM_003882.3	NP_003873.1	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	155	VWFC.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	21	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			GCTGCACACCACTGTGCCTCC	0.662000													75	107					0	0	1	0	0
SLC25A52	147407	broad.mit.edu	37	18	29340393	29340393	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:29340393G>A	ENST00000269205.5	-	1	450	c.262C>T	c.(262-264)Cga>Tga	p.R88*	SLC25A52_ENST00000579441.2_Nonsense_Mutation_p.R78*	NM_001034172.2	NP_001029344.3	Q3SY17	MCAR2_HUMAN	solute carrier family 25, member 52	78					transport	integral to membrane|mitochondrial inner membrane											TACAAATTTCGAAATCCATCC	0.463000													64	71					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6697724	6697724	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:6697724C>T	ENST00000245907.6	-	20	2614	c.2522G>A	c.(2521-2523)cGa>cAa	p.R841Q		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	841					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding	p.R841Q(1)		breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTGCTCGTTTCGAACAACAGA	0.572000													24	35					0	0	1	0	0
ADRA2A	150	broad.mit.edu	37	10	112838510	112838510	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:112838510C>T	ENST00000280155.2	+	1	1721	c.756C>T	c.(754-756)gaC>gaT	p.D252D		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	237					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding			breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	GGGGTCCGGACGCCGTCGCCG	0.751000													3	1					0	0	1	0	0
TUBB4A	10382	broad.mit.edu	37	19	6496198	6496198	+	Missense_Mutation	SNP	C	C	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:6496198C>G	ENST00000601152.1	-	4	361	c.236G>C	c.(235-237)gGc>gCc	p.G79A	TUBB4A_ENST00000598006.1_Missense_Mutation_p.G90A|TUBB4A_ENST00000264071.2_Silent_p.G104G|TUBB4A_ENST00000596926.1_3'UTR|TUBB4A_ENST00000540257.1_Silent_p.G104G			P04350	TBB4_HUMAN	tubulin, beta 4A class IVa	0					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity										CCGTGTAGTGCCCCTTTGCCC	0.627000													41	67					0	0	1	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47253710	47253710	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:47253710C>T	ENST00000296861.2	-	2	1111	c.718G>A	c.(718-720)Gaa>Aaa	p.E240K		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	240					cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			GAAGGGACTTCATGGGTTTCC	0.517000													26	41					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58253474	58253474	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:58253474C>T	ENST00000249750.4	-	11	2037	c.1270G>A	c.(1270-1272)Gaa>Aaa	p.E424K	ALDH1A2_ENST00000537372.1_Missense_Mutation_p.E403K|ALDH1A2_ENST00000559517.1_Missense_Mutation_p.E328K|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.E386K|ALDH1A2_ENST00000558231.1_Missense_Mutation_p.E395K	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	424					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CTCAAAATTTCCTGAACAGGG	0.393000													29	4					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95090106	95090106	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:95090106G>A	ENST00000553947.1	+	8	2190	c.1302G>A	c.(1300-1302)caG>caA	p.Q434Q	SERPINA3_ENST00000393078.3_Silent_p.Q409Q|SERPINA3_ENST00000482740.1_Silent_p.Q191Q|SERPINA3_ENST00000393080.4_Silent_p.Q409Q|SERPINA3_ENST00000467132.1_Silent_p.Q409Q			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	409					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		CAGACACCCAGAACATCTTCT	0.488000													30	88					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703858	4703858	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:4703858G>A	ENST00000396950.3	-	2	323	c.84C>T	c.(82-84)ttC>ttT	p.F28F		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		AAAGGAGGGGGAAGCCAACCC	0.502000													26	35					0	0	1	0	0
MUC15	143662	broad.mit.edu	37	11	26586830	26586830	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:26586830G>A	ENST00000436318.2	-	2	790	c.657C>T	c.(655-657)acC>acT	p.T219T	MUC15_ENST00000281268.8_Silent_p.T219T|ANO3_ENST00000525139.1_Intron|ANO3_ENST00000537978.1_Intron|MUC15_ENST00000527569.1_Silent_p.T219T|MUC15_ENST00000529533.1_Silent_p.T219T|MUC15_ENST00000455601.2_Silent_p.T192T|ANO3_ENST00000256737.3_Intron|ANO3_ENST00000531568.1_Intron			Q8N387	MUC15_HUMAN	mucin 15, cell surface associated	192						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25						CACTGTTTGTGGTAAGCCATC	0.398000													44	54					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907847	12907847	+	Missense_Mutation	SNP	C	C	T	rs150230498		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:12907847C>T	ENST00000317869.6	-	2	521	c.296G>A	c.(295-297)cGa>cAa	p.R99Q		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						CGCTGCTGATCGTTTCACACC	0.488000													27	96					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52886952	52886952	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:52886952G>A	ENST00000330722.6	-	1	89	c.21C>T	c.(19-21)acC>acT	p.T7T		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	7	Head.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		GGCTCCTGATGGTGGTGGATG	0.622000													18	15					0	0	1	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276889	71276889	+	Missense_Mutation	SNP	T	T	A	rs36179995		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:71276889T>A	ENST00000398531.1	+	1	281	c.256T>A	c.(256-258)Tcc>Acc	p.S86T	KRTAP5-10_ENST00000376536.4_Intron	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	86	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						GGGCTGTGGTTCCTGTGGGGG	0.687000													56	85					0	0	1	0	0
NARS2	79731	broad.mit.edu	37	11	78277273	78277273	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:78277273G>A	ENST00000281038.5	-	4	793	c.418C>T	c.(418-420)Cga>Tga	p.R140*	NARS2_ENST00000528850.1_5'UTR	NM_001243251.1|NM_024678.5	NP_001230180.1|NP_078954.4	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial (putative)	140					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)	27	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	GGATATTGTCGCAGATACTCC	0.373000													45	49					0	0	1	0	0
NBPF14	25832	broad.mit.edu	37	1	148004572	148004572	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:148004572C>T	ENST00000369219.1	-	22	2758	c.2742G>A	c.(2740-2742)caG>caA	p.Q914Q				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	914	NBPF 10.					cytoplasm				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					TGACTCCCATCTGGAACACCA	0.458000													49	367					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3081376	3081376	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:3081376C>T	ENST00000602557.1	-	29	4917	c.4362G>A	c.(4360-4362)ggG>ggA	p.G1454G	CSMD1_ENST00000539096.1_Silent_p.G1453G|CSMD1_ENST00000537824.1_Silent_p.G1453G|CSMD1_ENST00000542608.1_Silent_p.G1453G|CSMD1_ENST00000602723.1_Silent_p.G1454G|CSMD1_ENST00000400186.3_Silent_p.G1454G|CSMD1_ENST00000520002.1_Silent_p.G1454G|CSMD1_ENST00000523387.1_5'UTR			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1454	CUB 9.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCGTCAGATTCCCTCCACAAG	0.502000													20	4					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179427525	179427525	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179427525C>T	ENST00000589042.1	-	326	83558	c.83334G>A	c.(83332-83334)gtG>gtA	p.V27778V	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.V26137V|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Silent_p.V18838V|TTN_ENST00000342992.6_Silent_p.V25210V|TTN_ENST00000460472.2_Silent_p.V18713V|TTN_ENST00000342175.6_Silent_p.V18905V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	26137	Fibronectin type-III 102.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTCTTTCTTCACTTCTCTTA	0.398000													38	18					0	0	1	0	0
TSEN2	80746	broad.mit.edu	37	3	12546690	12546690	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:12546690C>T	ENST00000284995.6	+	6	1256	c.869C>T	c.(868-870)cCa>cTa	p.P290L	TSEN2_ENST00000454502.2_Missense_Mutation_p.P231L|TSEN2_ENST00000383797.5_Missense_Mutation_p.P290L|TSEN2_ENST00000402228.3_Missense_Mutation_p.P290L|TSEN2_ENST00000314571.7_Intron|TSEN2_ENST00000444864.1_Intron|TSEN2_ENST00000415684.1_Intron	NM_025265.3	NP_079541.1	Q8NCE0	SEN2_HUMAN	TSEN2 tRNA splicing endonuclease subunit	290					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)	19						AGAAGAAATCCATATAGGATC	0.348000													35	28					0	0	1	0	0
TMEM198	130612	broad.mit.edu	37	2	220412676	220412676	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:220412676C>T	ENST00000344458.2	+	4	1200	c.615C>T	c.(613-615)ctC>ctT	p.L205L	TMEM198_ENST00000373883.3_Silent_p.L205L			Q66K66	TM198_HUMAN	transmembrane protein 198	205	Leu-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	16		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		TGGAGCGACTCCGGGCTGCTC	0.687000													12	7					0	0	1	0	0
KIN	22944	broad.mit.edu	37	10	7801817	7801817	+	Missense_Mutation	SNP	A	A	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:7801817A>C	ENST00000543003.1	-	11	1116	c.837T>G	c.(835-837)aaT>aaG	p.N279K	KIN_ENST00000463666.1_Intron|KIN_ENST00000535925.1_Intron|KIN_ENST00000379562.3_Intron			O60870	KIN17_HUMAN	KIN, antigenic determinant of recA protein homolog (mouse)	0					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						TTTTTAAAGCATTTTGAAATT	0.299000													13	3					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10398395	10398395	+	Silent	SNP	C	C	T	rs148989691	byFrequency	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:10398395C>T	ENST00000226207.5	-	37	5413	c.5319G>A	c.(5317-5319)ctG>ctA	p.L1773L	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1773						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GTTCCTTCTTCAGCTCCTCAG	0.498000													96	111					0	0	1	0	0
COL8A2	1296	broad.mit.edu	37	1	36564446	36564446	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:36564446C>T	ENST00000397799.1	-	4	1060	c.836G>A	c.(835-837)gGt>gAt	p.G279D	COL8A2_ENST00000481785.1_Missense_Mutation_p.G214D|COL8A2_ENST00000303143.4_Missense_Mutation_p.G279D			P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2	279	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			NS(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GACTCCCACACCGTCTACTCC	0.706000													24	30					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152768689	152768689	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:152768689C>T	ENST00000367255.5	-	29	4174	c.3573G>A	c.(3571-3573)ttG>ttA	p.L1191L	SYNE1_ENST00000265368.4_Silent_p.L1191L|SYNE1_ENST00000367248.3_Silent_p.L1181L|SYNE1_ENST00000423061.1_Silent_p.L1198L|SYNE1_ENST00000367253.4_Silent_p.L1191L|SYNE1_ENST00000341594.5_Silent_p.L1257L|SYNE1_ENST00000448038.1_Silent_p.L1198L|SYNE1_ENST00000413186.2_Silent_p.L1191L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1191					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AAACTTCTGTCAAAACTTTCA	0.458000										HNSCC(10;0.0054)			23	30					0	0	1	0	0
LOC93432	93432	broad.mit.edu	37	7	141896542	141896542	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:141896542G>A	ENST00000477922.3	+	40	4612	c.4558G>A	c.(4558-4560)Gag>Aag	p.E1520K																	endometrium(1)|lung(5)	6						TGCTGAATATGAGATGTGTGT	0.478000													14	16					0	0	1	0	0
CTHRC1	115908	broad.mit.edu	37	8	104388112	104388112	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:104388112G>A	ENST00000330295.5	+	2	439	c.297G>A	c.(295-297)gaG>gaA	p.E99E	CTHRC1_ENST00000520337.1_Silent_p.E85E|CTHRC1_ENST00000415886.2_Silent_p.E99E	NM_138455.3	NP_612464.1	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	99						collagen				endometrium(1)|large_intestine(5)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)			AAAGCTTTGAGGAGTCCTGGA	0.473000													47	60					0	0	1	0	0
TMEM101	84336	broad.mit.edu	37	17	42090521	42090521	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:42090521G>A	ENST00000589334.1	-	4	636	c.321C>T	c.(319-321)gtC>gtT	p.V107V	TMEM101_ENST00000206380.3_Silent_p.V107V|TMEM101_ENST00000587529.1_Silent_p.V107V|TMEM101_ENST00000542039.1_Silent_p.V49V			Q96IK0	TM101_HUMAN	transmembrane protein 101	107					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		Breast(137;0.0264)|Prostate(33;0.0861)		BRCA - Breast invasive adenocarcinoma(366;0.113)		AGTACATACGGACCTAGGCCG	0.617000													11	16					0	0	1	0	0
TMEM108	66000	broad.mit.edu	37	3	133099842	133099842	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:133099842C>T	ENST00000515826.1	+	3	1410	c.1287C>T	c.(1285-1287)ttC>ttT	p.F429F	TMEM108_ENST00000393130.3_Silent_p.F429F|TMEM108_ENST00000508711.1_Intron|TMEM108_ENST00000321871.6_Silent_p.F429F			Q6UXF1	TM108_HUMAN	transmembrane protein 108	429						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						CAGGCAATTTCCTCAACCGCC	0.622000													31	57					0	0	1	0	0
DDX43	55510	broad.mit.edu	37	6	74119003	74119003	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:74119003G>A	ENST00000370336.4	+	10	1370	c.1212G>A	c.(1210-1212)atG>atA	p.M404I	DDX43_ENST00000479773.1_3'UTR	NM_018665.2	NP_061135.2	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	404	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						TGTTGGACATGGGATTTGAAC	0.383000													45	74					0	0	1	0	0
XPO4	64328	broad.mit.edu	37	13	21417936	21417936	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:21417936G>A	ENST00000400602.2	-	5	581	c.546C>T	c.(544-546)ttC>ttT	p.F182F	XPO4_ENST00000255305.6_Silent_p.F182F	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	182					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		AGTTACCATGGAATTCCATGC	0.333000													31	62					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79067089	79067089	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:79067089G>A	ENST00000388820.4	-	12	1963	c.1753C>T	c.(1753-1755)Cgc>Tgc	p.R585C	ADAMTS7_ENST00000566303.1_Intron	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	585	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						TTGCAGAGGCGGAAGCGCTTG	0.637000													14	86					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	70800616	70800616	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:70800616G>A	ENST00000333538.5	+	2	953	c.319G>A	c.(319-321)Gaa>Aaa	p.E107K	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	107						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TTCCCCGGCTGAAGAAGAAAA	0.488000													23	48					0	0	1	0	0
GAA	2548	broad.mit.edu	37	17	78085843	78085843	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:78085843C>T	ENST00000302262.3	+	12	1917	c.1698C>T	c.(1696-1698)tcC>tcT	p.S566S	GAA_ENST00000390015.3_Silent_p.S566S	NM_000152.3	NP_000143.2	P10253	LYAG_HUMAN	glucosidase, alpha; acid	566			S -> P (in GSD2; infantile form).		cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	AGTTTCTCTCCACACACTACA	0.662000													48	70					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067508	9067508	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:9067508C>T	ENST00000397910.4	-	3	20141	c.19938G>A	c.(19936-19938)agG>agA	p.R6646R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6648	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCATCTCAATCCTTGTAATCT	0.502000													54	71					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1093537	1093537	+	Nonsense_Mutation	SNP	A	A	T	rs80200693		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:1093537A>T	ENST00000441003.2	+	30	5383	c.5356A>T	c.(5356-5358)Aag>Tag	p.K1786*	MUC2_ENST00000359061.5_Nonsense_Mutation_p.1742_1742ins*|MUC2_ENST00000333592.6_Nonsense_Mutation_p.K74*|MUC2_ENST00000361558.6_Intron	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1778						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	caccagcacaaagagtacaac	0.602000													13	17					0	0	1	0	0
BAK1	578	broad.mit.edu	37	6	33543609	33543609	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:33543609G>A	ENST00000374467.3	-	3	415	c.167C>T	c.(166-168)gCc>gTc	p.A56V	BAK1_ENST00000360661.5_Missense_Mutation_p.A56V|BAK1_ENST00000442998.2_Missense_Mutation_p.A56V	NM_001188.3	NP_001179.1	Q16611	BAK_HUMAN	BCL2-antagonist/killer 1	56					activation of pro-apoptotic gene products|cellular response to mechanical stimulus|cellular response to UV|establishment or maintenance of transmembrane electrochemical gradient|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|release of cytochrome c from mitochondria	integral to mitochondrial outer membrane|pore complex	metal ion binding|protein heterodimerization activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4						CTCTGGGTCGGCAGGGGCAGC	0.592000													33	87					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133799649	133799649	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:133799649G>A	ENST00000321016.8	-	12	1778	c.1548C>T	c.(1546-1548)gtC>gtT	p.V516V	IGSF9B_ENST00000533871.2_Silent_p.V516V			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	516	Fibronectin type-III 1.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCTGGACCCGGACACTGCCCG	0.597000													29	39					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33291520	33291520	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:33291520G>A	ENST00000280979.4	+	13	4671	c.4501G>A	c.(4501-4503)Ggt>Agt	p.G1501S	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1501					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CCTGCTTCGTGGTTTTTATTT	0.383000													15	50					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151165537	151165537	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:151165537G>A	ENST00000282466.3	-	4	2231	c.2232C>T	c.(2230-2232)ttC>ttT	p.F744F		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	744					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAGAGGGAGGGAAATGCCTCC	0.473000													32	45					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109687221	109687221	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:109687221A>G	ENST00000277225.5	+	3	1317	c.1028A>G	c.(1027-1029)tAc>tGc	p.Y343C	ZNF462_ENST00000457913.1_Missense_Mutation_p.Y343C			Q96JM2	ZN462_HUMAN	zinc finger protein 462	343					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						CCCATGTCTTACCCTCAGATG	0.483000													33	4					0	0	1	0	0
HIST1H1B	3009	broad.mit.edu	37	6	27835053	27835053	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:27835053C>T	ENST00000331442.3	-	1	306	c.255G>A	c.(253-255)ctG>ctA	p.L85L		NM_005322.2	NP_005313.1	P16401	H15_HUMAN	histone cluster 1, H1b	85	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(12)|prostate(2)|upper_aerodigestive_tract(2)	24						TCTTGAGGCCCAGCTTAATGC	0.572000													90	238					0	0	1	0	0
KRT37	8688	broad.mit.edu	37	17	39580293	39580293	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:39580293G>A	ENST00000225550.3	-	1	482	c.483C>T	c.(481-483)ctC>ctT	p.L161L	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	161	Coil 1B.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				CCTTCTGCTGGAGCTCCTCGA	0.577000													44	66					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974695	49974695	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:49974695C>T	ENST00000555099.1	+	1	753	c.721C>T	c.(721-723)Cac>Tac	p.H241Y		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	241					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H241N(1)		autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						CTGTGTCTCCCACATCACAGT	0.463000													61	19					0	0	1	0	0
SLAMF9	89886	broad.mit.edu	37	1	159923229	159923229	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:159923229G>A	ENST00000368093.3	-	2	377	c.261C>T	c.(259-261)agC>agT	p.S87S	SLAMF9_ENST00000368092.3_Silent_p.S87S|SLAMF9_ENST00000466773.1_Intron	NM_033438.3	NP_254273.2	Q96A28	SLAF9_HUMAN	SLAM family member 9	87						integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGTCCAGGAAGCTCACTTGGC	0.522000													42	45					0	0	1	0	0
TMEM198	130612	broad.mit.edu	37	2	220412677	220412677	+	Missense_Mutation	SNP	C	C	T	rs146753639		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:220412677C>T	ENST00000344458.2	+	4	1201	c.616C>T	c.(616-618)Cgg>Tgg	p.R206W	TMEM198_ENST00000373883.3_Missense_Mutation_p.R206W			Q66K66	TM198_HUMAN	transmembrane protein 198	206	Leu-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	16		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GGAGCGACTCCGGGCTGCTCC	0.687000													12	7					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36779381	36779381	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:36779381G>A	ENST00000361475.2	-	4	685	c.512C>T	c.(511-513)tCg>tTg	p.S171L	TGM2_ENST00000536724.1_Missense_Mutation_p.S111L|TGM2_ENST00000536701.1_Missense_Mutation_p.S90L	NM_004613.2|NM_198951.1	NP_004604.2|NP_945189.1	P21980	TGM2_HUMAN	transglutaminase 2	171					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			endometrium(2)|large_intestine(11)|liver(1)|lung(7)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	GAACTTGGCCGAGCCCTGGTA	0.577000													76	104					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150327218	150327218	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:150327218C>T	ENST00000328902.5	-	2	229	c.13G>A	c.(13-15)Gaa>Aaa	p.E5K	GIMAP6_ENST00000493969.1_Missense_Mutation_p.E5K	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	5							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGTTCATATTCTTCTTCCTCC	0.423000													43	67					0	0	1	0	0
TRBV6-8	28599	broad.mit.edu	37	7	142124391	142124391	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:142124391G>A	ENST00000390376.2	-	0	86																											TCAGGATGTGGAATTTTGGGG	0.522000													41	66					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57181116	57181116	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:57181116G>A	ENST00000504228.1	+	6	1553	c.1448G>A	c.(1447-1449)aGa>aAa	p.R483K	KIAA1211_ENST00000264229.6_Missense_Mutation_p.R483K|KIAA1211_ENST00000541073.1_Missense_Mutation_p.R476K			Q6ZU35	K1211_HUMAN	KIAA1211	483	Glu-rich.									endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					GAGGAAAAGAGAGAAGAAGGG	0.642000													3	14					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159653645	159653645	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:159653645C>T	ENST00000297267.9	+	11	2301	c.2101C>T	c.(2101-2103)Ccc>Tcc	p.P701S	FNDC1_ENST00000340366.6_Missense_Mutation_p.P638S	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	701	Ser-rich.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CCGGAGGACCCCCCATTCAGG	0.692000													8	14					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111757899	111757899	+	Missense_Mutation	SNP	A	A	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:111757899A>C	ENST00000261726.6	+	17	2240	c.2086A>C	c.(2086-2088)Atc>Ctc	p.I696L		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	696						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CATCAAGAGCATCCTGGAGCA	0.726000													3	8					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751397	140751397	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:140751397C>T	ENST00000576222.1	+	1	1567	c.1436C>T	c.(1435-1437)cCc>cTc	p.P479L	PCDHGA5_ENST00000518069.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCTCGGATCCCGACTTGGGA	0.612000													27	79					0	0	1	0	0
HSPA6	3310	broad.mit.edu	37	1	161496362	161496362	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:161496362C>T	ENST00000309758.4	+	1	2327	c.1914C>T	c.(1912-1914)atC>atT	p.I638I		NM_002155.3	NP_002146.2	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	638					response to unfolded protein		ATP binding			endometrium(3)|large_intestine(5)|lung(9)|prostate(2)|skin(2)	21	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CCGGCCCCATCATTGAGGAGG	0.597000													15	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179449496	179449496	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179449496C>T	ENST00000589042.1	-	310	65096	c.64872G>A	c.(64870-64872)ctG>ctA	p.L21624L	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.L19983L|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Silent_p.L12684L|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000342992.6_Silent_p.L19056L|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000460472.2_Silent_p.L12559L|TTN_ENST00000342175.6_Silent_p.L12751L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19983	Fibronectin type-III 57.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCCTGGGATCAGCTTTCCAA	0.498000													254	168					0	0	1	0	0
NME8	51314	broad.mit.edu	37	7	37936623	37936623	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:37936623C>T	ENST00000199447.4	+	17	2068	c.1696C>T	c.(1696-1698)Cat>Tat	p.H566Y	NME8_ENST00000440017.1_Missense_Mutation_p.H566Y|EPDR1_ENST00000476620.1_Intron	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	566	NDK 3.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										AAACATTGTCCATGGAGCATC	0.413000													28	33					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121780261	121780261	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:121780261T>C	ENST00000261367.7	+	10	2995	c.1567T>C	c.(1567-1569)Ttg>Ctg	p.L523L	CTC-210G5.1_ENST00000509993.1_RNA|SNCAIP_ENST00000261368.8_Silent_p.L476L|SNCAIP_ENST00000379538.3_Silent_p.L110L|SNCAIP_ENST00000503116.2_3'UTR|SNCAIP_ENST00000542191.1_Silent_p.L34L|CTC-210G5.1_ENST00000503529.1_RNA|SNCAIP_ENST00000379533.2_Silent_p.L523L|CTC-210G5.1_ENST00000510972.1_RNA|SNCAIP_ENST00000414317.2_Silent_p.L78L|SNCAIP_ENST00000379536.2_Silent_p.L416L|CTC-210G5.1_ENST00000506053.1_RNA|SNCAIP_ENST00000504884.2_3'UTR			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	476					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CTGACAGACCTTGGTTGAATA	0.478000													27	77					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11651059	11651059	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:11651059C>T	ENST00000262442.3	+	32	6654	c.6586C>T	c.(6586-6588)Cca>Tca	p.P2196S	DNAH9_ENST00000454412.2_Missense_Mutation_p.P2196S	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2196	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CATCATCAATCCAGCCACAGG	0.527000													26	38					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231157442	231157442	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:231157442G>A	ENST00000392045.3	+	20	2021	c.1907G>A	c.(1906-1908)aGa>aAa	p.R636K	SP140_ENST00000486687.2_Missense_Mutation_p.R560K|SP140_ENST00000343805.6_Missense_Mutation_p.R576K|SP140_ENST00000417495.3_Missense_Mutation_p.R522K|SP140_ENST00000350136.5_Missense_Mutation_p.R505K|SP140_ENST00000420434.3_Missense_Mutation_p.R609K	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	636	SAND.				defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GGCCATGCAAGATCAAAGAAC	0.512000													67	54					0	0	1	0	0
DTL	51514	broad.mit.edu	37	1	212273912	212273912	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:212273912C>T	ENST00000366991.4	+	14	1894	c.1580C>T	c.(1579-1581)cCg>cTg	p.P527L	DTL_ENST00000475419.1_3'UTR|DTL_ENST00000542077.1_Missense_Mutation_p.P485L	NM_016448.2	NP_057532.2	Q9NZJ0	DTL_HUMAN	denticleless E3 ubiquitin protein ligase homolog (Drosophila)	527					DNA replication|G2/M transition DNA damage checkpoint|protein monoubiquitination|protein polyubiquitination|response to UV|translesion synthesis|ubiquitin-dependent protein catabolic process	centrosome|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|nuclear membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(81;0.00796)|all cancers(67;0.0385)|Epithelial(68;0.102)		ATCATGTCTCCGAGAAAAGCC	0.493000													32	56					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57209892	57209892	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:57209892C>T	ENST00000343433.6	-	10	1515	c.1435G>A	c.(1435-1437)Ggg>Agg	p.G479R	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	479										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						TTAGAGACCCCTAGGTCTGGA	0.433000													44	66					0	0	1	0	0
DRGX	644168	broad.mit.edu	37	10	50574190	50574190	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:50574190C>T	ENST00000374139.2	-	6	773	c.763G>A	c.(763-765)Gaa>Aaa	p.E255K	DRGX_ENST00000434016.1_Missense_Mutation_p.E260K			C9JW76	C9JW76_HUMAN	dorsal root ganglia homeobox	260					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	11						TCGCTCTGTTCCTTGGTGGGA	0.667000													26	9					0	0	1	0	0
CELF4	56853	broad.mit.edu	37	18	34854307	34854307	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:34854307G>A	ENST00000420428.2	-	6	1163	c.768C>T	c.(766-768)atC>atT	p.I256I	CELF4_ENST00000591287.1_Silent_p.I255I|CELF4_ENST00000601019.1_Silent_p.I255I|CELF4_ENST00000591282.1_Silent_p.I256I|CELF4_ENST00000361795.5_Silent_p.I255I|CELF4_ENST00000412753.1_Silent_p.I256I|CELF4_ENST00000334919.5_Silent_p.I246I|CELF4_ENST00000588597.1_Silent_p.I245I|CELF4_ENST00000603232.1_Silent_p.I256I|RP11-797E24.3_ENST00000588766.1_RNA	NM_020180.3	NP_064565.1	Q9BZC1	CELF4_HUMAN	CUGBP, Elav-like family member 4	256	Necessary for TNNT2 exon 5 inclusion.|Sufficient for RNA-binding and MSE- dependent splicing activity.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	44						CCCCGAAAGGGATGGCCATGG	0.647000													55	81					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394181	233394181	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:233394181C>T	ENST00000258229.8	-	5	1661	c.1427G>A	c.(1426-1428)gGa>gAa	p.G476E	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	476						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GATGGCATTTCCCCCCTCCCC	0.547000													21	24					0	0	1	0	0
NUDT2	318	broad.mit.edu	37	9	34343206	34343206	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:34343206C>T	ENST00000379158.2	+	5	570	c.212C>T	c.(211-213)aCc>aTc	p.T71I	NUDT2_ENST00000379155.5_Missense_Mutation_p.T71I|NUDT2_ENST00000346365.4_Missense_Mutation_p.T71I	NM_001161.4	NP_001152.1	P50583	AP4A_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 2	71	Nudix hydrolase.				induction of apoptosis|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity|bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity|GTP binding			lung(3)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		GGCCAGCTGACCATTATTGAG	0.507000													94	24					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63256279	63256279	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:63256279C>T	ENST00000323865.3	-	1	1501	c.1268G>A	c.(1267-1269)tGa>tAa	p.*423*	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	0					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CCTCCGTCATCACTGGCGGCA	0.478000													55	146					0	0	1	0	0
PPP1CA	5499	broad.mit.edu	37	11	67167056	67167056	+	Nonsense_Mutation	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:67167056C>A	ENST00000376745.4	-	4	647	c.499G>T	c.(499-501)Gaa>Taa	p.E167*	PPP1CA_ENST00000532446.1_5'UTR|PPP1CA_ENST00000312989.7_Nonsense_Mutation_p.E178*|PPP1CA_ENST00000358239.4_Nonsense_Mutation_p.E123*	NM_001008709.1|NM_002708.3	NP_001008709.1|NP_002699.1	P62136	PP1A_HUMAN	protein phosphatase 1, catalytic subunit, alpha isozyme	167					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	cytosol|MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|lung(2)|pancreas(1)|urinary_tract(3)	7			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			AAGATCTTTTCGTCCACTATG	0.597000													22	39					2.44723e-14	2.46789e-14	1	1	0
ABCC3	8714	broad.mit.edu	37	17	48761318	48761318	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:48761318C>T	ENST00000285238.8	+	28	4043	c.3963C>T	c.(3961-3963)atC>atT	p.I1321I		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1321	ABC transporter 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	AGGTGGGGATCGTGGGCCGCA	0.612000													19	26					0	0	1	0	0
ATP6V0A1	535	broad.mit.edu	37	17	40618525	40618525	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:40618525C>T	ENST00000343619.4	+	3	319	c.196_splice	c.e3+1	p.R66_splice	ATP6V0A1_ENST00000393829.2_Splice_Site_p.R66_splice|ATP6V0A1_ENST00000264649.6_Splice_Site_p.R66_splice|ATP6V0A1_ENST00000537728.1_Splice_Site_p.R66_splice|ATP6V0A1_ENST00000585525.1_Splice_Site_p.R66_splice|ATP6V0A1_ENST00000546249.1_Splice_Site_p.R66_splice|ATP6V0A1_ENST00000544137.1_Intron	NM_001130021.1	NP_001123493.1	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	66					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|urinary_tract(3)	26		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		TCGAAAGCTTCGTATGTGCAC	0.318000													39	47					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118199193	118199193	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:118199193G>A	ENST00000425217.1	-	4	576	c.522C>T	c.(520-522)tcC>tcT	p.S174S	KSR2_ENST00000339824.5_Silent_p.S203S	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	203					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGACGCACTTGGACGGGACCC	0.677000													24	19					0	0	1	0	0
CDKL5	6792	broad.mit.edu	37	X	18622845	18622845	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:18622845C>T	ENST00000379989.3	+	13	2086	c.1801C>T	c.(1801-1803)Ccc>Tcc	p.P601S	CDKL5_ENST00000463994.1_3'UTR|CDKL5_ENST00000379996.3_Missense_Mutation_p.P601S	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	601					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					CTACACCAGCCCCTTTTCTTC	0.512000													112	17					0	0	1	0	0
SLC4A1	6521	broad.mit.edu	37	17	42340231	42340231	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:42340231C>T	ENST00000262418.6	-	2	159	c.4G>A	c.(4-6)Gag>Aag	p.E2K	AC003043.1_ENST00000597382.1_Intron	NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1	2					bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	40		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TGCAGCTCCTCCATGGCGTGG	0.637000													75	72					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947150	237947150	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:237947150G>A	ENST00000366574.2	+	90	12455	c.12138G>A	c.(12136-12138)agG>agA	p.R4046R	RYR2_ENST00000360064.6_Silent_p.R4052R|RYR2_ENST00000542537.1_Silent_p.R4030R	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4046	EF-hand.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTCCAAGAGGGACTTCCACA	0.423000													15	25					0	0	1	0	0
PABPN1L	390748	broad.mit.edu	37	16	88931526	88931526	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:88931526C>T	ENST00000419291.2	-	4	481	c.470G>A	c.(469-471)gGg>gAg	p.G157E	PABPN1L_ENST00000411789.2_Missense_Mutation_p.G157E|PABPN1L_ENST00000427766.1_Intron|PABPN1L_ENST00000378358.4_Missense_Mutation_p.G157E	NM_001080487.2	NP_001073956.2	A6NDY0	EPAB2_HUMAN	poly(A) binding protein, nuclear 1-like (cytoplasmic)	157	RRM.					cytoplasm	nucleotide binding|RNA binding			kidney(1)	1						GGCGGAGCCCCCGTAGTCCAC	0.637000													6	10					0	0	1	0	0
PTPN21	11099	broad.mit.edu	37	14	88936315	88936315	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:88936315A>G	ENST00000556564.1	-	16	3235	c.2951T>C	c.(2950-2952)aTg>aCg	p.M984T	PTPN21_ENST00000328736.3_Missense_Mutation_p.M984T	NM_007039.3	NP_008970.2	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type 21	984	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|liver(1)|lung(7)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						TTCCCATACCATCTGCCAAAA	0.403000													40	36					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233490631	233490631	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:233490631C>T	ENST00000366624.3	+	4	1446	c.1185C>T	c.(1183-1185)ctC>ctT	p.L395L	MLK4_ENST00000366623.3_Silent_p.L395L	NM_032435.2	NP_115811.2																					CCTTAATTCTCGAACAGTTGA	0.383000													57	71					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189873729	189873729	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:189873729C>T	ENST00000304636.3	+	48	3775	c.3605C>T	c.(3604-3606)gCc>gTc	p.A1202V	COL3A1_ENST00000317840.5_Missense_Mutation_p.A899V	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1202	Nonhelical region (C-terminal).				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGTGTTGGAGCCGCTGCCATT	0.542000													103	53					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656040	19656040	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:19656040C>T	ENST00000586018.1	+	8	2806	c.2704C>T	c.(2704-2706)Cac>Tac	p.H902Y	CILP2_ENST00000291495.4_Missense_Mutation_p.H896Y			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	896						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GACTGCCAGCCACTTCCGCTT	0.692000													23	41					0	0	1	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44221314	44221314	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:44221314T>C	ENST00000371554.1	+	12	2368	c.2154T>C	c.(2152-2154)tcT>tcC	p.S718S	HSP90AB1_ENST00000371646.5_Silent_p.S718S|HSP90AB1_ENST00000353801.3_Silent_p.S718S			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	718					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AGGATGCGTCTCGCATGGAAG	0.517000											OREG0017471	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	80					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49211993	49211993	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:49211993C>T	ENST00000327979.2	-	16	2362	c.1951G>A	c.(1951-1953)Gaa>Aaa	p.E651K	FAM65C_ENST00000535356.1_Missense_Mutation_p.E655K|FAM65C_ENST00000045083.2_Missense_Mutation_p.E651K			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	651										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GCCACTTCTTCCAGGAGGCAT	0.517000													79	86					0	0	1	0	0
DEPDC1	55635	broad.mit.edu	37	1	68944879	68944879	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:68944879G>A	ENST00000456315.2	-	10	2174	c.2060C>T	c.(2059-2061)tCt>tTt	p.S687F	DEPDC1_ENST00000370966.5_Missense_Mutation_p.S403F|RP4-694A7.2_ENST00000425820.1_RNA	NM_001114120.1	NP_001107592.1	Q5TB30	DEP1A_HUMAN	DEP domain containing 1	687					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		CTGTAAGTAAGAGGGTACTTG	0.373000													34	39					0	0	1	0	0
DAP3	7818	broad.mit.edu	37	1	155697499	155697499	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:155697499C>T	ENST00000368336.5	+	7	697	c.573C>T	c.(571-573)ttC>ttT	p.F191F	MSTO1_ENST00000538143.1_Intron|DAP3_ENST00000535183.1_Silent_p.F150F|DAP3_ENST00000343043.3_Silent_p.F191F|MSTO1_ENST00000452804.2_Intron|DAP3_ENST00000471214.1_3'UTR|DAP3_ENST00000421487.2_Silent_p.F157F	NM_001199849.1|NM_004632.3	NP_001186778.1|NP_004623.1	P51398	RT29_HUMAN	death associated protein 3	191					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	24	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TGAAGAATTTCAAAACTACAA	0.448000													47	69					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106194	55106194	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:55106194G>A	ENST00000453777.1	+	4	305	c.135G>A	c.(133-135)gtG>gtA	p.V45V	LILRA1_ENST00000251372.3_Silent_p.V45V|LILRB1_ENST00000418536.2_Intron|LILRA1_ENST00000473156.1_3'UTR|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	45	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GGAGTCCCGTGACCCTCTGGT	0.542000													68	78					0	0	1	0	0
CEL	1056	broad.mit.edu	37	9	135945903	135945903	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:135945903C>T	ENST00000372080.4	+	10	1367	c.1351C>T	c.(1351-1353)Ccc>Tcc	p.P451S	CEL_ENST00000351304.7_Intron	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	448					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		GCCCGTCTACCCCAAATGGGT	0.617000													49	15					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73676435	73676435	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:73676435C>T	ENST00000264448.6	+	8	2889	c.2778C>T	c.(2776-2778)ttC>ttT	p.F926F	ALMS1_ENST00000409009.1_Silent_p.F884F|ALMS1_ENST00000377715.1_Silent_p.F926F	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	926	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						ACTTTCTTTTCCCTGAAGAAG	0.468000													46	77					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134993468	134993468	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:134993468C>T	ENST00000535938.1	+	17	2290	c.2123C>T	c.(2122-2124)tCa>tTa	p.S708L	SAGE1_ENST00000537770.1_Missense_Mutation_p.S332L|SAGE1_ENST00000370709.3_Missense_Mutation_p.S708L|SAGE1_ENST00000324447.3_Missense_Mutation_p.S708L	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	708										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					GCTGGTATTTCATGCAGAAGT	0.458000													74	10					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144943093	144943093	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:144943093G>A	ENST00000525985.1	-	2	4400	c.4329C>T	c.(4327-4329)gaC>gaT	p.D1443D				P58107	EPIPL_HUMAN	epiplakin 1	1443						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGGTGTGGTCGTCCACCTCAA	0.617000													26	49					0	0	1	0	0
BRD1	23774	broad.mit.edu	37	22	50217206	50217206	+	Missense_Mutation	SNP	C	C	T	rs147334124		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:50217206C>T	ENST00000216267.8	-	1	1246	c.760G>A	c.(760-762)Ggc>Agc	p.G254S	BRD1_ENST00000457780.2_Missense_Mutation_p.G254S|BRD1_ENST00000404760.1_Missense_Mutation_p.G254S|BRD1_ENST00000404034.1_Missense_Mutation_p.G254S	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	254					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGCCACTGGCCCTCGGGGATG	0.637000													52	29					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													4	67					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72267064	72267064	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:72267064C>T	ENST00000340726.3	-	3	716	c.77G>A	c.(76-78)gGt>gAt	p.G26D	EYA1_ENST00000388743.2_Missense_Mutation_p.G26D|EYA1_ENST00000388742.4_Missense_Mutation_p.G26D|EYA1_ENST00000303824.7_Missense_Mutation_p.G26D|EYA1_ENST00000388741.2_Intron|EYA1_ENST00000419131.1_Missense_Mutation_p.G26D|EYA1_ENST00000388740.3_Intron	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	26					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			ATGAGAGTTACCGAGTTTGGG	0.463000													107	153					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179650464	179650464	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179650464C>T	ENST00000589042.1	-	15	2600	c.2376G>A	c.(2374-2376)aaG>aaA	p.K792K	TTN_ENST00000591111.1_Silent_p.K792K|TTN_ENST00000359218.5_Silent_p.K746K|TTN_ENST00000342992.6_Silent_p.K792K|TTN_ENST00000460472.2_Silent_p.K746K|TTN_ENST00000342175.6_Silent_p.K746K|TTN_ENST00000360870.5_Silent_p.K792K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	792							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTAGTTTTCTTGATCTGCA	0.418000													66	46					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10405196	10405196	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:10405196G>A	ENST00000226207.5	-	25	3238	c.3144C>T	c.(3142-3144)atC>atT	p.I1048I	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1048						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GATCCATCCGGATTTTCTTTT	0.348000													13	30					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14763884	14763884	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:14763884G>A	ENST00000358984.4	+	7	1200	c.1020G>A	c.(1018-1020)ttG>ttA	p.L340L	ANKRD30B_ENST00000447268.2_Silent_p.L340L|ANKRD30B_ENST00000579292.1_Intron	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	340										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						GGAAAATTTTGAGGCCTACAA	0.403000													16	20					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38592577	38592577	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:38592577G>A	ENST00000413689.1	-	28	5479	c.5286C>T	c.(5284-5286)atC>atT	p.I1762I	SCN5A_ENST00000425664.1_Silent_p.I1744I|SCN5A_ENST00000414099.2_Silent_p.I1744I|SCN5A_ENST00000423572.2_Silent_p.I1761I|SCN5A_ENST00000455624.2_Silent_p.I1729I|SCN5A_ENST00000451551.2_Silent_p.I1708I|SCN5A_ENST00000333535.4_Silent_p.I1762I|SCN5A_ENST00000450102.2_Silent_p.I1708I|SCN5A_ENST00000443581.1_Silent_p.I1761I|SCN5A_ENST00000449557.2_Silent_p.I1708I	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1762					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGTTGACCACGATGAGGAAGG	0.572000													62	69					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32026129	32026129	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:32026129C>T	ENST00000375244.3	-	22	7732	c.7531G>A	c.(7531-7533)Gaa>Aaa	p.E2511K	TNXB_ENST00000375247.2_Missense_Mutation_p.E2511K			P22105	TENX_HUMAN	tenascin XB	2571	Fibronectin type-III 17.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GTGCCTGGTTCTGTAGGGCTG	0.592000													18	31					0	0	1	0	0
EEF2	1938	broad.mit.edu	37	19	3980661	3980661	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:3980661G>A	ENST00000309311.6	-	9	1285	c.1197C>T	c.(1195-1197)tcC>tcT	p.S399S		NM_001961.3	NP_001952.1	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	399						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACCATTTTGGAAATATACA	0.532000													24	34					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160788098	160788098	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:160788098G>A	ENST00000263285.5	+	6	1463	c.1433G>A	c.(1432-1434)cGa>cAa	p.R478Q	LY9_ENST00000341032.4_Missense_Mutation_p.R388Q|LY9_ENST00000368040.1_Missense_Mutation_p.R130Q|LY9_ENST00000368041.2_Missense_Mutation_p.R348Q|LY9_ENST00000368035.1_Missense_Mutation_p.R130Q	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	478					cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ATTTGGAAGCGAAAAGGACGG	0.522000													28	30					0	0	1	0	0
LOXL4	84171	broad.mit.edu	37	10	100013540	100013540	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:100013540C>T	ENST00000260702.3	-	11	1755	c.1605G>A	c.(1603-1605)ctG>ctA	p.L535L	RP11-34A14.3_ENST00000433374.1_RNA	NM_032211.6	NP_115587.6	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4	535	Lysyl-oxidase like.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(8)|ovary(4)|prostate(1)|skin(2)	26		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		CGTTCATCACCAGGTCTGGTG	0.622000													25	7					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69095033	69095033	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:69095033C>T	ENST00000332644.5	-	8	1049	c.888G>A	c.(886-888)atG>atA	p.M296I		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	296	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						CTGAGAGCTTCATTTTGGCTT	0.378000													44	62					0	0	1	0	0
TMEM92	162461	broad.mit.edu	37	17	48356586	48356586	+	Missense_Mutation	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:48356586C>A	ENST00000300433.3	+	6	507	c.397C>A	c.(397-399)Ccc>Acc	p.P133T	TMEM92_ENST00000507382.1_Missense_Mutation_p.P133T	NM_001168215.1	NP_001161687.1	Q6UXU6	TMM92_HUMAN	transmembrane protein 92	133	Pro-rich.					integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(1)	7						GGGCCCAACTCCCACAGAGCC	0.607000													110	202					4.09656e-53	4.17178e-53	1	1	0
FPR1	2357	broad.mit.edu	37	19	52249975	52249975	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:52249975C>T	ENST00000595042.1	-	3	414	c.273G>A	c.(271-273)tgG>tgA	p.W91*	FPR1_ENST00000304748.4_Nonsense_Mutation_p.W91*	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	91					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	AGCCGAAAGGCCAATGTCCTC	0.522000													39	63					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179604915	179604915	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:179604915C>T	ENST00000444136.1	+	9	1663	c.1413C>T	c.(1411-1413)tcC>tcT	p.S471S	TDRD5_ENST00000294848.8_Silent_p.S471S|TDRD5_ENST00000367614.1_Silent_p.S471S	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	471					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						ACACCAGTTCCCTCATAGGGG	0.458000													34	47					0	0	1	0	0
HLA-B	3106	broad.mit.edu	37	6	31323289	31323289	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:31323289G>A	ENST00000412585.2	-	4	728	c.700C>T	c.(700-702)Cct>Tct	p.P234S		NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B									p.P234A(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						ATCTCCGCAGGGTAGAAACCC	0.582000									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				52	102					0	0	1	0	0
CDKL5	6792	broad.mit.edu	37	X	18622846	18622846	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:18622846C>T	ENST00000379989.3	+	13	2087	c.1802C>T	c.(1801-1803)cCc>cTc	p.P601L	CDKL5_ENST00000463994.1_3'UTR|CDKL5_ENST00000379996.3_Missense_Mutation_p.P601L	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	601					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					TACACCAGCCCCTTTTCTTCC	0.512000													113	17					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187194302	187194302	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:187194302C>T	ENST00000264692.4	+	4	629	c.296C>T	c.(295-297)tCt>tTt	p.S99F	F11_ENST00000403665.2_Missense_Mutation_p.S99F|F11_ENST00000492972.2_Missense_Mutation_p.S99F			P03951	FA11_HUMAN	coagulation factor XI	99	Apple 1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity	p.S99F(1)		NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	TCTGGGTATTCTTTCAAGCAA	0.383000													33	38					0	0	1	0	0
ANKRD34A	284615	broad.mit.edu	37	1	145473962	145473962	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:145473962G>A	ENST00000323397.4	+	4	1927	c.634G>A	c.(634-636)Gac>Aac	p.D212N		NM_001039888.2	NP_001034977.1	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34A	212								p.D212Y(1)		endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	20	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGAGAAGCGGGACGTATTTGA	0.602000													64	91					0	0	1	0	0
DTL	51514	broad.mit.edu	37	1	212273911	212273911	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:212273911C>T	ENST00000366991.4	+	14	1893	c.1579C>T	c.(1579-1581)Ccg>Tcg	p.P527S	DTL_ENST00000475419.1_3'UTR|DTL_ENST00000542077.1_Missense_Mutation_p.P485S	NM_016448.2	NP_057532.2	Q9NZJ0	DTL_HUMAN	denticleless E3 ubiquitin protein ligase homolog (Drosophila)	527					DNA replication|G2/M transition DNA damage checkpoint|protein monoubiquitination|protein polyubiquitination|response to UV|translesion synthesis|ubiquitin-dependent protein catabolic process	centrosome|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|nuclear membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(81;0.00796)|all cancers(67;0.0385)|Epithelial(68;0.102)		GATCATGTCTCCGAGAAAAGC	0.488000													32	57					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17108134	17108134	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:17108134C>T	ENST00000443236.1	-	11	1054	c.1023G>A	c.(1021-1023)cgG>cgA	p.R341R	CPAMD8_ENST00000388925.4_Silent_p.R294R	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	294						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						TGTCGAAGTCCCGGGAGCCGA	0.602000													5	10					0	0	1	0	0
TTC17	55761	broad.mit.edu	37	11	43380505	43380505	+	Translation_Start_Site	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:43380505A>G	ENST00000039989.4	+	1	15	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	TTC17_ENST00000299240.6_Start_Codon_SNP_p.M1V|RP11-484D2.2_ENST00000526220.1_RNA	NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	1							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						GGGGGGCAAGATGGCGGCGGC	0.706000													12	4					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73759262	73759262	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:73759262G>A	ENST00000334126.7	-	28	5709	c.5483C>T	c.(5482-5484)tCc>tTc	p.S1828F	C2CD3_ENST00000313663.7_Missense_Mutation_p.S1828F			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1828						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					CCCAGGAGAGGAGAAATCAAG	0.458000													13	17					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423667	56423667	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:56423667C>T	ENST00000588751.1	-	5	1540	c.1516G>A	c.(1516-1518)Gag>Aag	p.E506K	NLRP13_ENST00000342929.3_Missense_Mutation_p.E506K			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	506	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TCCAGGCCCTCGATCTCAGTG	0.473000													35	58					0	0	1	0	0
GLYCTK	132158	broad.mit.edu	37	3	52324415	52324415	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:52324415C>T	ENST00000354773.4	+	2	153	c.57C>T	c.(55-57)ctC>ctT	p.L19L	GLYCTK_ENST00000473032.1_Silent_p.L19L|GLYCTK-AS1_ENST00000493616.1_RNA|GLYCTK_ENST00000477382.1_Silent_p.L19L|GLYCTK_ENST00000461183.1_Intron|GLYCTK_ENST00000436784.2_Silent_p.L19L|GLYCTK_ENST00000471180.1_Intron|GLYCTK_ENST00000305690.8_Silent_p.L19L	NM_001144951.1	NP_001138423.1	Q8IVS8	GLCTK_HUMAN	glycerate kinase	19					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding	p.L19L(1)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		TGCATCCACTCCTCTGGCGGG	0.682000													12	37					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64600308	64600308	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:64600308C>T	ENST00000342711.5	-	25	2854	c.2855G>A	c.(2854-2856)gGc>gAc	p.G952D		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	952	PH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						CGACAGAAAGCCCTCATAGGC	0.692000													4	6					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1261264	1261264	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:1261264C>T	ENST00000348261.5	+	22	4568	c.4320C>T	c.(4318-4320)ttC>ttT	p.F1440F	CACNA1H_ENST00000358590.4_Silent_p.F1440F|CACNA1H_ENST00000565831.1_Silent_p.F1440F	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1440					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GCTGCGCCTTCTTCATCATTT	0.632000													62	81					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059304	9059304	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:9059304G>A	ENST00000397910.4	-	3	28345	c.28142C>T	c.(28141-28143)aCc>aTc	p.T9381I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9383	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAAGGTAAAGGTACCCTGCGA	0.507000													65	95					0	0	1	0	0
PRDM10	56980	broad.mit.edu	37	11	129814821	129814821	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:129814821G>A	ENST00000358825.5	-	6	838	c.607C>T	c.(607-609)Cgg>Tgg	p.R203W	PRDM10_ENST00000360871.3_Missense_Mutation_p.R203W|PRDM10_ENST00000423662.2_Missense_Mutation_p.R117W|PRDM10_ENST00000528746.1_Missense_Mutation_p.R177W|PRDM10_ENST00000304538.6_Missense_Mutation_p.R117W|PRDM10_ENST00000526082.1_Missense_Mutation_p.R117W	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R203W(1)		breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		GCCCTGGCCCGGGTGAGCACC	0.642000													49	61					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38819412	38819412	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:38819412G>A	ENST00000359357.3	+	37	5031	c.4777G>A	c.(4777-4779)Gaa>Aaa	p.E1593K	DNAH8_ENST00000449981.2_Missense_Mutation_p.E1810K|DNAH8_ENST00000441566.1_Missense_Mutation_p.E1593K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGTTCTCCTGGAAATTCTTGG	0.373000													22	46					0	0	1	0	0
PRKAG2	51422	broad.mit.edu	37	7	151273500	151273500	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:151273500G>A	ENST00000287878.4	-	7	1407	c.903C>T	c.(901-903)gtC>gtT	p.V301V	PRKAG2_ENST00000433631.2_Silent_p.V176V|PRKAG2_ENST00000418337.2_Silent_p.V60V|PRKAG2_ENST00000392801.2_Silent_p.V257V|PRKAG2_ENST00000492843.1_Silent_p.V177V	NM_016203.3	NP_057287.2	Q9UGJ0	AAKG2_HUMAN	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	301	CBS 1.				ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|upper_aerodigestive_tract(1)	26	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		GCGCTGCTCGGACACCGTTGG	0.413000													19	18					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54873332	54873332	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:54873332C>T	ENST00000333896.5	+	22	4932	c.4545_splice	c.e22-1	p.T1516_splice	SPTBN1_ENST00000356805.4_Splice_Site_p.T1529_splice	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	1529					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			TCCCTCCAGACCCTCCAGAAA	0.527000													82	124					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78927929	78927929	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:78927929C>T	ENST00000261751.3	-	2	167	c.55_splice	c.e2-1	p.G19_splice	CHRNB4_ENST00000412074.2_Splice_Site_p.G19_splice|CHRNB4_ENST00000560511.1_5'UTR	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	19					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						GCGGCAGTTCCCTGAGAAAAC	0.592000													122	182					0	0	1	0	0
RAF1	5894	broad.mit.edu	37	3	12641300	12641300	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:12641300C>T	ENST00000251849.4	-	10	1437	c.998G>A	c.(997-999)cGt>cAt	p.R333H	RAF1_ENST00000534997.1_Missense_Mutation_p.R118H|RAF1_ENST00000442415.2_Missense_Mutation_p.R353H|RAF1_ENST00000542177.1_Missense_Mutation_p.R252H	NM_002880.3	NP_002871.1	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog 1	333					activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|RAF1/DAZL(2)|SRGAP3/RAF1(6)	biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	32					Sorafenib(DB00398)	TCTCTGTCCACGAGGCCTCTG	0.408000			T	SRGAP3	pilocytic astrocytoma				Noonan syndrome				19	71					0	0	1	0	0
BRD1	23774	broad.mit.edu	37	22	50187788	50187788	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:50187788G>A	ENST00000216267.8	-	6	2739	c.2253C>T	c.(2251-2253)ctC>ctT	p.L751L	BRD1_ENST00000342989.5_Silent_p.L346L|BRD1_ENST00000542442.1_Silent_p.L439L|BRD1_ENST00000457780.2_Silent_p.L751L|BRD1_ENST00000404760.1_Silent_p.L751L|BRD1_ENST00000404034.1_Silent_p.L751L	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	751					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GCTTGTTTCGGAGAAGGGCAA	0.642000													31	68					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168312101	168312101	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:168312101A>G	ENST00000366806.2	+	15	2111	c.1969A>G	c.(1969-1971)Aca>Gca	p.T657A	MLLT4_ENST00000447894.2_Missense_Mutation_p.T657A|MLLT4_ENST00000392112.1_Missense_Mutation_p.T641A|MLLT4_ENST00000351017.4_Missense_Mutation_p.T657A|MLLT4_ENST00000400822.3_Missense_Mutation_p.T656A|MLLT4_ENST00000392108.3_Missense_Mutation_p.T657A|MLLT4_ENST00000344191.4_Missense_Mutation_p.T657A			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	657					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CATCAGCCCTACAGAGCGCAC	0.483000			T	MLL	AL								24	44					0	0	1	0	0
YY2	404281	broad.mit.edu	37	X	21875397	21875397	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:21875397C>T	ENST00000429584.2	+	1	1293	c.795C>T	c.(793-795)ttC>ttT	p.F265F	MBTPS2_ENST00000379484.5_Intron|MBTPS2_ENST00000465888.1_3'UTR|MBTPS2_ENST00000365779.2_Intron	NM_206923.3	NP_996806.2	O15391	TYY2_HUMAN	YY2 transcription factor	265	Mediates transcriptional repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(2)	19						AAAAGATGTTCCGGGATTACG	0.488000													149	16					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140594475	140594475	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:140594475C>T	ENST00000341948.4	+	1	967	c.780C>T	c.(778-780)ttC>ttT	p.F260F		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		260	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGTAGGCTTCCTGGTTGTGA	0.473000													52	131					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157516962	157516962	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:157516962G>A	ENST00000361835.3	-	3	235	c.78C>T	c.(76-78)ttC>ttT	p.F26F	FCRL5_ENST00000356953.4_Silent_p.F26F|FCRL5_ENST00000368189.3_Silent_p.F26F|FCRL5_ENST00000368188.2_Silent_p.F26F|FCRL5_ENST00000368190.3_Silent_p.F26F|FCRL5_ENST00000368191.3_Intron	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	26	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity	p.F26L(1)		breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GAGGCTGGAGGAAAATAATGG	0.537000													54	79					0	0	1	0	0
TMEM145	284339	broad.mit.edu	37	19	42828940	42828940	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:42828940C>T	ENST00000301204.3	+	15	1494	c.1453C>T	c.(1453-1455)Cgg>Tgg	p.R485W		NM_173633.2	NP_775904.2	Q8NBT3	TM145_HUMAN	transmembrane protein 145	485						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				CCGTGACCTCCGGCCCCCTGG	0.726000													17	17					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126882995	126882995	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:126882995C>T	ENST00000339582.2	-	2	1072	c.264G>A	c.(262-264)aaG>aaA	p.K88K	GRM8_ENST00000405249.1_Silent_p.K88K|GRM8_ENST00000358373.3_Silent_p.K88K|GRM8_ENST00000444921.2_Silent_p.K88K			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	88					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GATCAGGGTCCTTGTTAATCT	0.522000										HNSCC(24;0.065)			17	31					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96796894	96796894	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:96796894G>A	ENST00000371270.3	-	9	1558	c.1464C>T	c.(1462-1464)atC>atT	p.I488I	CYP2C8_ENST00000535898.1_Silent_p.I386I	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	488					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	TTCAGACAGGGATGAAGCAGA	0.428000													30	6					0	0	1	0	0
LHFPL5	222662	broad.mit.edu	37	6	35773582	35773582	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:35773582C>T	ENST00000360215.1	+	1	512	c.135C>T	c.(133-135)atC>atT	p.I45I	LHFPL5_ENST00000373853.1_Silent_p.I45I	NM_182548.3	NP_872354.1	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	45						integral to membrane				endometrium(4)|large_intestine(4)|lung(7)|prostate(2)|skin(2)|urinary_tract(1)	20						CCCTCTTCATCCAGCCCTACT	0.582000													92	159					0	0	1	0	0
HMOX2	3163	broad.mit.edu	37	16	4559640	4559640	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:4559640G>A	ENST00000570646.1	+	6	1439	c.834G>A	c.(832-834)gaG>gaA	p.E278E	HMOX2_ENST00000575120.1_Silent_p.E249E|HMOX2_ENST00000414777.1_Silent_p.E278E|HMOX2_ENST00000458134.3_Silent_p.E278E|HMOX2_ENST00000398595.3_Silent_p.E278E|HMOX2_ENST00000219700.6_Silent_p.E278E|HMOX2_ENST00000406590.2_Silent_p.E278E	NM_002134.3	NP_002125.3	P30519	HMOX2_HUMAN	heme oxygenase (decycling) 2	278					cellular iron ion homeostasis|heme catabolic process|heme oxidation|response to hypoxia|transmembrane transport	endoplasmic reticulum membrane|microsome|plasma membrane	electron carrier activity|heme oxygenase (decyclizing) activity|metal ion binding|protein binding			endometrium(1)|large_intestine(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	8					NADH(DB00157)	GTGCCCTGGAGGGCAGCAGCT	0.617000													52	93					0	0	1	0	0
RSRC1	51319	broad.mit.edu	37	3	158261191	158261191	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:158261191C>T	ENST00000464171.1	+	8	778	c.653C>T	c.(652-654)cCa>cTa	p.P218L	RSRC1_ENST00000312179.6_Missense_Mutation_p.P218L|RSRC1_ENST00000295930.3_Missense_Mutation_p.P276L|RSRC1_ENST00000480820.1_Missense_Mutation_p.P276L|RSRC1_ENST00000475278.2_Intron	NM_001271834.1	NP_001258763.1	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	276					nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding			cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|upper_aerodigestive_tract(1)	18			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			GTTGCTGATCCACCCAGTACT	0.408000													33	44					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33338002	33338002	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:33338002G>A	ENST00000374796.2	-	10	4566	c.1996C>T	c.(1996-1998)Ccg>Tcg	p.P666S	NCOA6_ENST00000359003.2_Missense_Mutation_p.P666S			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	666	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						TTTTGGCTCGGGGGGTTCACC	0.567000													45	54					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16945385	16945385	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:16945385G>A	ENST00000412962.1	-	0	2134																											CCGCCAGATGGGATGCTGGAA	0.602000													6	39					0	0	1	0	0
OR8S1	341568	broad.mit.edu	37	12	48921815	48921815	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:48921815C>T	ENST00000310194.1	+	2	1009	c.1009C>T	c.(1009-1011)Ccg>Tcg	p.P337S	OR8S1_ENST00000551654.1_3'UTR	NM_001005203.2	NP_001005203.2	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S, member 1	337					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|skin(4)	22						GCTGAGCATTCCGGTCACGCC	0.677000													6	15					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109661650	109661650	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:109661650G>A	ENST00000338432.7	+	27	3942	c.3823G>A	c.(3823-3825)Gac>Aac	p.D1275N	ACACB_ENST00000377854.5_Missense_Mutation_p.D1205N|ACACB_ENST00000377848.3_Missense_Mutation_p.D1275N			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1275					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	AACCATCTTCGACGTCCTGCC	0.428000													156	143					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100126624	100126624	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:100126624C>T	ENST00000524871.1	+	17	2428	c.2138C>T	c.(2137-2139)tCc>tTc	p.S713F	CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000528682.1_Missense_Mutation_p.S713F|CNTN5_ENST00000279463.3_Missense_Mutation_p.S713F|CNTN5_ENST00000418526.2_Missense_Mutation_p.S639F|CNTN5_ENST00000527185.1_Missense_Mutation_p.S713F	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	713	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGCCCATTTTCCCTGGGCTGG	0.493000													30	47					0	0	1	0	0
MTMR2	8898	broad.mit.edu	37	11	95598807	95598807	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:95598807C>T	ENST00000393223.3	-	5	666	c.4G>A	c.(4-6)Gaa>Aaa	p.E2K	MTMR2_ENST00000409459.1_Missense_Mutation_p.E2K|MTMR2_ENST00000352297.7_Missense_Mutation_p.E2K|MTMR2_ENST00000484818.1_5'UTR|MTMR2_ENST00000346299.5_Missense_Mutation_p.E74K	NM_001243571.1|NM_201278.2	NP_001230500.1|NP_958435.1	Q13614	MTMR2_HUMAN	myotubularin related protein 2	74						nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	19		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GGTGGTTCTTCCATTTCTGCT	0.383000													69	85					0	0	1	0	0
RP11-909M7.3	0	broad.mit.edu	37	14	101435304	101435304	+	RNA	SNP	A	A	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:101435304A>C	ENST00000554693.2	+	0	212				SNORD114-12_ENST00000365400.1_RNA																							GATGACAAATACCGGCGTATG	0.353000													20	58					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196791224	196791224	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:196791224C>T	ENST00000312428.6	-	22	3638	c.3538G>A	c.(3538-3540)Gga>Aga	p.G1180R		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1180	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ACAGTCTGTCCAGGCCAATCC	0.363000													33	80					0	0	1	0	0
F10	2159	broad.mit.edu	37	13	113798329	113798329	+	Missense_Mutation	SNP	A	A	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:113798329A>C	ENST00000375559.3	+	6	705	c.667A>C	c.(667-669)Acg>Ccg	p.T223P	F10_ENST00000409306.1_Missense_Mutation_p.T223P|F10_ENST00000375551.3_Missense_Mutation_p.T223P	NM_000504.3	NP_000495.1	P00742	FA10_HUMAN	coagulation factor X	223					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(4)|lung(10)|pancreas(1)|stomach(1)	18	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTTCAACCAGACGCAGCCTGA	0.612000													28	115					0	0	1	0	0
SLC16A2	6567	broad.mit.edu	37	X	73641833	73641833	+	Missense_Mutation	SNP	G	G	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:73641833G>T	ENST00000276033.5	+	1	749	c.583G>T	c.(583-585)Gtc>Ttc	p.V195F	SLC16A2_ENST00000587091.1_Missense_Mutation_p.V121F			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	121						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	CCATAACTCTGTCGGGATCCT	0.602000													13	1					7.93312e-07	7.95874e-07	1	1	0
HCLS1	3059	broad.mit.edu	37	3	121354584	121354584	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:121354584G>A	ENST00000314583.3	-	9	780	c.689C>T	c.(688-690)gCc>gTc	p.A230V	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Missense_Mutation_p.A193V	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	230					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		AGCCTCACCGGCTTCTATGGG	0.512000													49	57					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13851	13851	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrM:13851C>T	ENST00000361567.2	+	1	1515	c.1515C>T	c.(1513-1515)aaC>aaT	p.N505N				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	505					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	CTAGACCTCAACTACCTAACC	0.463000													70	80					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196659125	196659125	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:196659125G>A	ENST00000312428.6	-	57	10753	c.10653C>T	c.(10651-10653)atC>atT	p.I3551I	DNAH7_ENST00000409063.1_Silent_p.I34I	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3551	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATGATCGAATGATATTAGCCC	0.453000													81	66					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11097598	11097598	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:11097598C>T	ENST00000470054.1	-	0	271									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ggggactcctccttcatcagc	0.542000													4	47					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38793944	38793944	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:38793944G>A	ENST00000449082.2	-	11	1520	c.1521C>T	c.(1519-1521)ttC>ttT	p.F507F		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	507					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CAGGGGACCGGAAATGGAACA	0.572000													30	29					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115524003	115524003	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:115524003T>C	ENST00000369522.3	+	29	2669	c.2429T>C	c.(2428-2430)tTg>tCg	p.L810S	SYCP1_ENST00000369518.1_Missense_Mutation_p.L810S|SYCP1_ENST00000477590.1_3'UTR	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	810					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TATTGGAAATTGGATTCTAAA	0.323000													50	55					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168112875	168112875	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:168112875G>A	ENST00000519560.1	-	31	3791	c.3372C>T	c.(3370-3372)gaC>gaT	p.D1124D	SLIT3_ENST00000404867.3_Silent_p.D1124D|SLIT3_ENST00000332966.8_Silent_p.D1131D	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1124	EGF-like 6.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACTCGTACTGGTCGCATGGGC	0.642000													10	17					0	0	1	0	0
ADA	100	broad.mit.edu	37	20	43251687	43251687	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:43251687G>A	ENST00000372874.4	-	7	773	c.639C>T	c.(637-639)gtC>gtT	p.V213V	ADA_ENST00000537820.1_Intron|PKIG_ENST00000372882.3_Intron|ADA_ENST00000464097.1_5'UTR|PKIG_ENST00000372887.1_Intron	NM_000022.2	NP_000013.2	P00813	ADA_HUMAN	adenosine deaminase	213					adenosine catabolic process|cell adhesion|hypoxanthine salvage|inosine biosynthetic process|negative regulation of adenosine receptor signaling pathway|purine nucleotide salvage|purine ribonucleoside monophosphate biosynthetic process|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation	cell junction|cytoplasmic membrane-bounded vesicle lumen|cytosol|external side of plasma membrane|lysosome	adenosine deaminase activity|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|pancreas(2)|prostate(3)|skin(2)|urinary_tract(1)	18		all_lung(126;1.24e-07)|Lung NSC(126;1.94e-07)|Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)		Adenosine(DB00640)|Cladribine(DB00242)|Dipyridamole(DB00975)|Erythromycin(DB00199)|Fludarabine(DB01073)|Idoxuridine(DB00249)|Nelarabine(DB01280)|Pentostatin(DB00552)|Theophylline(DB00277)|Vidarabine(DB00194)	CCCCGGCGTGGACAGTACGGT	0.652000									Adenosine Deaminase Deficiency				41	66					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3765828	3765828	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:3765828C>T	ENST00000324932.7	-	12	1739	c.1319G>A	c.(1318-1320)gGa>gAa	p.G440E	NUP98_ENST00000397004.4_Missense_Mutation_p.G440E|NUP98_ENST00000397007.4_Missense_Mutation_p.G457E|NUP98_ENST00000359171.4_Missense_Mutation_p.G440E|NUP98_ENST00000355260.3_Missense_Mutation_p.G440E	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	457	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AAGAGGCCCTCCAATCTTAGG	0.512000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								31	51					0	0	1	0	0
SNAPC4	6621	broad.mit.edu	37	9	139290162	139290162	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:139290162G>A	ENST00000298532.2	-	3	606	c.238C>T	c.(238-240)Cct>Tct	p.P80S		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	80					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GGGTCTTCAGGGAGGGTTTTA	0.567000													183	21					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60461843	60461843	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:60461843G>A	ENST00000373886.3	+	3	251	c.247G>A	c.(247-249)Gaa>Aaa	p.E83K		NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	83					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						GATCATGGAGGAAACAAATAC	0.328000													10	9					0	0	1	0	0
SPICE1	152185	broad.mit.edu	37	3	113184512	113184512	+	Missense_Mutation	SNP	G	G	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:113184512G>C	ENST00000295872.4	-	11	1534	c.1275C>G	c.(1273-1275)aaC>aaG	p.N425K		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	425					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						GTGTAGCAGCGTTTTCTTCTC	0.388000													59	86					0	0	1	0	0
SPHK2	56848	broad.mit.edu	37	19	49132706	49132706	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:49132706C>T	ENST00000443164.1	+	5	2532	c.1827C>T	c.(1825-1827)agC>agT	p.S609S	SPHK2_ENST00000340932.3_Silent_p.S509S|SPHK2_ENST00000245222.4_Silent_p.S547S|SPHK2_ENST00000599029.1_Silent_p.S511S|SPHK2_ENST00000600537.1_Silent_p.S488S|SPHK2_ENST00000598088.1_Silent_p.S547S|SPHK2_ENST00000599748.1_Silent_p.S511S			Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	547					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		TCTCGCCCAGCCACCTAGGCG	0.711000													15	17					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79947382	79947382	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:79947382G>A	ENST00000373275.4	-	30	3637	c.3421C>T	c.(3421-3423)Cat>Tat	p.H1141Y	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1141										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						TCTCTGGAATGAGCCCCCCAC	0.478000													21	0					0	0	1	0	0
SERPINI2	5276	broad.mit.edu	37	3	167159941	167159941	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:167159941G>A	ENST00000476257.1	-	10	1472	c.1174C>T	c.(1174-1176)Cct>Tct	p.P392S	SERPINI2_ENST00000471111.1_Missense_Mutation_p.P392S|SERPINI2_ENST00000264677.4_Missense_Mutation_p.P392S|SERPINI2_ENST00000461846.1_Missense_Mutation_p.P392S			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	392					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						TGGGTGTCAGGATTTGTCACT	0.323000													16	29					0	0	1	0	0
MT-ATP6	4508	broad.mit.edu	37	MT	8947	8947	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrM:8947C>T	ENST00000361899.2	+	1	421	c.421C>T	c.(421-423)Cta>Tta	p.L141L						mitochondrially encoded ATP synthase 6											breast(2)|endometrium(7)|kidney(8)|prostate(1)	18						TTATCCCCATACTAGTTATTA	0.483000													82	64					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71026984	71026984	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:71026984G>A	ENST00000318789.4	-	15	1868	c.1343C>T	c.(1342-1344)tCg>tTg	p.S448L	FOXP1_ENST00000498215.1_Missense_Mutation_p.S448L|FOXP1_ENST00000475937.1_Missense_Mutation_p.S448L|FOXP1_ENST00000484350.1_Missense_Mutation_p.S372L|FOXP1_ENST00000491238.1_Missense_Mutation_p.S450L|FOXP1_ENST00000493089.1_Missense_Mutation_p.S448L|FOXP1_ENST00000468577.1_Missense_Mutation_p.S448L	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	448					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		TCTACCTGACGAAATGGGCAC	0.488000			T	PAX5	ALL								47	67					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189931159	189931159	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:189931159C>T	ENST00000374866.3	-	23	1794	c.1520G>A	c.(1519-1521)gGt>gAt	p.G507D		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	507					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TCCTGGGTCACCTCTGGGACC	0.478000													120	289					0	0	1	0	0
C2orf54	79919	broad.mit.edu	37	2	241829509	241829509	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:241829509C>T	ENST00000307486.8	-	3	458	c.360G>A	c.(358-360)ctG>ctA	p.L120L	C2orf54_ENST00000402775.2_Silent_p.L101L|C2orf54_ENST00000388934.4_Silent_p.L269L			Q08AI8	CB054_HUMAN	chromosome 2 open reading frame 54	269										haematopoietic_and_lymphoid_tissue(1)|lung(4)|prostate(1)	6		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		AGAGGCTGTCCAGGCGATGAC	0.672000													63	28					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55889947	55889947	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:55889947C>T	ENST00000313472.3	+	1	99	c.99C>T	c.(97-99)ctC>ctT	p.L33L		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					TGCTATTTCTCCTCATATACC	0.453000													111	149					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140588530	140588530	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:140588530C>T	ENST00000239450.2	+	1	240	c.51C>T	c.(49-51)ttC>ttT	p.F17F	PCDHB12_ENST00000541609.1_Intron	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		17					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding	p.F17L(1)		NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTGCTTTTCTTTGTTTTGC	0.483000													56	44					0	0	1	0	0
ADPRHL2	54936	broad.mit.edu	37	1	36557639	36557639	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:36557639C>T	ENST00000373178.4	+	4	675	c.645C>T	c.(643-645)ctC>ctT	p.L215L		NM_017825.2	NP_060295.1	Q9NX46	ARHL2_HUMAN	ADP-ribosylhydrolase like 2	215						cytoplasm|nucleus	metal ion binding|poly(ADP-ribose) glycohydrolase activity			cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|pancreas(1)	8		Myeloproliferative disorder(586;0.0393)				TCAAGCAACTCCTGGGCCACA	0.612000													40	50					0	0	1	0	0
TUBB4B	10383	broad.mit.edu	37	9	140137801	140137801	+	Silent	SNP	G	G	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:140137801G>T	ENST00000340384.4	+	4	1279	c.1131G>T	c.(1129-1131)ctG>ctT	p.L377L		NM_006088.5	NP_006079.1	P68371	TBB2C_HUMAN	tubulin, beta 4B class IVb	377					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding										TCCAGGAGCTGTTCAAGCGCA	0.592000													171	19					2.21559e-100	2.25924e-100	1	1	0
PRSS35	167681	broad.mit.edu	37	6	84233841	84233841	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:84233841G>A	ENST00000536636.1	+	3	1026	c.681G>A	c.(679-681)gcG>gcA	p.A227A	PRSS35_ENST00000369700.3_Silent_p.A227A	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	227	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		GGGAGAGAGCGAAGGGTGGGA	0.542000													24	20					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	162206911	162206911	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:162206911G>A	ENST00000366898.1	-	7	866	c.764C>T	c.(763-765)tCc>tTc	p.S255F	PARK2_ENST00000366896.1_Missense_Mutation_p.S106F|PARK2_ENST00000338468.3_Missense_Mutation_p.S64F|PARK2_ENST00000366897.1_Missense_Mutation_p.S227F|PARK2_ENST00000366892.1_Missense_Mutation_p.S255F|PARK2_ENST00000366894.1_Missense_Mutation_p.S64F	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	255					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CACGTGGCGGGAGTTGCACTG	0.502000													11	8					0	0	1	0	0
GOLGA6L7P	728310	broad.mit.edu	37	15	29091047	29091047	+	RNA	SNP	T	T	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:29091047T>G	ENST00000569815.1	-	0	385					NR_047567.1																						TCCACTCACCTCTAGCTGCCT	0.493000													12	3					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76753933	76753933	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:76753933C>T	ENST00000536229.3	+	1	2252	c.1543C>T	c.(1543-1545)Ccg>Tcg	p.P515S	SALL3_ENST00000575389.2_Missense_Mutation_p.P648S|SALL3_ENST00000537592.2_Missense_Mutation_p.P648S			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	648					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GGCCCAGTTTCCGTTCGGGGG	0.652000													12	2					0	0	1	0	0
ANKRD28	23243	broad.mit.edu	37	3	15762511	15762511	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:15762511A>G	ENST00000399451.2	-	8	1184	c.817T>C	c.(817-819)Ttt>Ctt	p.F273L	ANKRD28_ENST00000497037.1_5'UTR|ANKRD28_ENST00000383777.1_Missense_Mutation_p.F306L	NM_001195098.1|NM_001195099.1|NM_015199.3	NP_001182027.1|NP_001182028.1|NP_056014.2	O15084	ANR28_HUMAN	ankyrin repeat domain 28	273						nucleoplasm	protein binding			breast(2)|endometrium(1)|large_intestine(2)|prostate(1)	6						AAAGGAGTAAATCCTTTTTCA	0.393000													80	122					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33133751	33133751	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:33133751C>T	ENST00000341947.2	-	62	4666	c.4439G>A	c.(4438-4440)gGa>gAa	p.G1480E	COL11A2_ENST00000357486.1_Missense_Mutation_p.G1459E|COL11A2_ENST00000361917.1_Missense_Mutation_p.G1373E|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000374714.1_Missense_Mutation_p.G1454E|COL11A2_ENST00000374713.1_Missense_Mutation_p.G1433E|COL11A2_ENST00000374712.1_Missense_Mutation_p.G1399E|COL11A2_ENST00000374708.4_Missense_Mutation_p.G1394E|COL11A2_ENST00000395197.1_Missense_Mutation_p.G1420E	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1480	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TCCCTTGGGTCCGCCTGGGCC	0.597000													9	46					0	0	1	0	0
YIF1B	90522	broad.mit.edu	37	19	38799698	38799698	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:38799698C>T	ENST00000392124.3	-	3	624		c.e3-1		YIF1B_ENST00000587361.1_Splice_Site|YIF1B_ENST00000591755.1_Splice_Site|YIF1B_ENST00000329420.8_Splice_Site|YIF1B_ENST00000591784.1_Splice_Site|YIF1B_ENST00000592694.1_Splice_Site|YIF1B_ENST00000592246.1_Splice_Site|YIF1B_ENST00000339413.6_Splice_Site|YIF1B_ENST00000337679.8_Splice_Site	NM_033557.3	NP_291035.1	Q5BJH7	YIF1B_HUMAN	Yip1 interacting factor homolog B (S. cerevisiae)							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|prostate(1)	10	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CTTCCCAGTCCTGCGGGGATG	0.662000													9	21					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201355545	201355545	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:201355545C>T	ENST00000391967.2	-	3	1245	c.944G>A	c.(943-945)gGg>gAg	p.G315E	LAD1_ENST00000367313.3_Missense_Mutation_p.G329E	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	315						basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						CAGGTTCTTCCCAGGGAGGGC	0.677000													36	38					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102900862	102900862	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:102900862A>G	ENST00000359520.7	+	9	1934	c.1708A>G	c.(1708-1710)Atg>Gtg	p.M570V	TECPR2_ENST00000558678.1_Missense_Mutation_p.M570V	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	570							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						TAGAACTGAAATGCCACACTG	0.532000													19	36					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	124999969	124999969	+	Splice_Site	SNP	G	G	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:124999969G>T	ENST00000431078.1	+	3	744	c.381_splice	c.e3+1	p.W127_splice		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	127	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		GACAGCATCTGGGTAGGACAT	0.428000													10	9					4.68919e-08	4.70738e-08	1	1	0
PHF21B	112885	broad.mit.edu	37	22	45309780	45309780	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:45309780G>A	ENST00000313237.5	-	5	903	c.753C>T	c.(751-753)ccC>ccT	p.P251P	PHF21B_ENST00000403565.1_Silent_p.P47P|PHF21B_ENST00000447824.3_Silent_p.P197P|PHF21B_ENST00000404079.2_Silent_p.P197P|PHF21B_ENST00000396103.3_Silent_p.P209P	NM_138415.4	NP_612424.1	Q96EK2	PF21B_HUMAN	PHD finger protein 21B	251							zinc ion binding	p.P251P(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(14)|ovary(2)|prostate(1)|skin(2)	25		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		GCTCCTCTGTGGGCGGCCGCG	0.627000													73	188					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95481655	95481655	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:95481655C>T	ENST00000432432.2	-	0	1705					NR_040113.1																						TGTCATTTTTCATTGTACATA	0.299000													47	97					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7288061	7288061	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:7288061C>T	ENST00000537408.1	+	3	1096	c.558C>T	c.(556-558)tcC>tcT	p.S186S	CLSTN3_ENST00000266546.6_Silent_p.S174S			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	174	Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						GTGACTGCTCCCCCCAGTACA	0.577000													42	82					0	0	1	0	0
SEZ6	124925	broad.mit.edu	37	17	27287921	27287921	+	Nonsense_Mutation	SNP	G	G	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:27287921G>T	ENST00000317338.12	-	6	1739	c.1311C>A	c.(1309-1311)taC>taA	p.Y437*	SEZ6_ENST00000360295.9_Nonsense_Mutation_p.Y437*|SEZ6_ENST00000442608.3_Nonsense_Mutation_p.Y437*|PIPOX_ENST00000583215.1_Intron|SEZ6_ENST00000335960.6_Nonsense_Mutation_p.Y437*			Q53EL9	SEZ6_HUMAN	seizure related 6 homolog (mouse)	437	CUB 1.					integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	29	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			GGTTGTTGCTGTAGTTGCCCG	0.597000													88	121					6.88379e-33	6.98271e-33	1	1	0
ZNF99	7652	broad.mit.edu	37	19	22941624	22941624	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:22941624G>A	ENST00000397104.3	-	5	813	c.814C>T	c.(814-816)Cat>Tat	p.H272Y	ZNF99_ENST00000596209.1_Missense_Mutation_p.H363Y					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TCTTCAGTATGAATTATCTCA	0.363000													45	50					0	0	1	0	0
ADHFE1	137872	broad.mit.edu	37	8	67372616	67372616	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:67372616C>T	ENST00000396623.3	+	13	1267	c.1236C>T	c.(1234-1236)ttC>ttT	p.F412F	ADHFE1_ENST00000415254.1_Silent_p.F364F|ADHFE1_ENST00000496501.1_3'UTR|C8orf46_ENST00000482608.2_3'UTR	NM_144650.2	NP_653251.2	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	412					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding	p.F364F(2)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	29		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			AATTCTTATTCGATCTGGATG	0.537000											OREG0018808	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	89	120					0	0	1	0	0
SPG20	23111	broad.mit.edu	37	13	36888548	36888548	+	Missense_Mutation	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:36888548C>A	ENST00000451493.1	-	6	1516	c.1299G>T	c.(1297-1299)tgG>tgT	p.W433C	SPG20_ENST00000355182.4_Missense_Mutation_p.W433C|SPG20_ENST00000438666.2_Missense_Mutation_p.W433C|SPG20_ENST00000494062.2_Missense_Mutation_p.W433C	NM_001142295.1	NP_001135767.1	Q8N0X7	SPG20_HUMAN	spastic paraplegia 20 (Troyer syndrome)	433					cell death	cytoplasm	ubiquitin protein ligase binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	27		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		CCCAACTCACCCAGGAAGCAC	0.363000													75	58					1.15773e-35	1.17667e-35	1	1	0
OR5P3	120066	broad.mit.edu	37	11	7846728	7846728	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:7846728G>A	ENST00000328375.1	-	1	791	c.792C>T	c.(790-792)tcC>tcT	p.S264S	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTGAGTAGCTGGACTTGGGCA	0.522000													42	57					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38228490	38228490	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:38228490G>A	ENST00000373048.4	-	2	137	c.138C>T	c.(136-138)gcC>gcT	p.A46A	EPHA10_ENST00000319637.6_Silent_p.A46A|EPHA10_ENST00000427468.2_Silent_p.A46A	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	46						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGCCCAGCTCGGCCTGGGAGG	0.532000													4	1					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52523879	52523879	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:52523879G>A	ENST00000242839.4	-	12	2940	c.2784C>T	c.(2782-2784)atC>atT	p.I928I	ATP7B_ENST00000400366.3_Silent_p.I817I|ATP7B_ENST00000418097.2_Silent_p.I928I|ATP7B_ENST00000344297.5_Intron|ATP7B_ENST00000400370.3_Silent_p.I498I|ATP7B_ENST00000417240.2_Silent_p.I200I|ATP7B_ENST00000482841.1_Intron|ATP7B_ENST00000448424.2_Silent_p.I850I	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	928					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		ACATGATGATGATAAATGGGA	0.403000									Wilson disease				48	121					0	0	1	0	0
HIPK1	204851	broad.mit.edu	37	1	114510562	114510562	+	Silent	SNP	C	C	T	rs139567945		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:114510562C>T	ENST00000369558.1	+	12	2788	c.2556C>T	c.(2554-2556)gtC>gtT	p.V852V	HIPK1_ENST00000369553.1_Silent_p.V458V|HIPK1_ENST00000340480.4_Silent_p.V478V|HIPK1_ENST00000369554.2_Silent_p.V807V|HIPK1_ENST00000369555.2_Silent_p.V807V|HIPK1_ENST00000426820.2_Silent_p.V852V|HIPK1_ENST00000369559.4_Silent_p.V852V|HIPK1_ENST00000406344.1_Silent_p.V458V|HIPK1_ENST00000369561.4_Silent_p.V818V			Q86Z02	HIPK1_HUMAN	homeodomain interacting protein kinase 1	852					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|prostate(2)	39	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGCTCCAGTCTCTTCCAAGT	0.428000													20	31					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55135721	55135721	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:55135721C>T	ENST00000314706.3	+	1	362	c.362C>T	c.(361-363)tCc>tTc	p.S121F		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						AAGACCATTTCCTTTCAGGGT	0.388000													96	116					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140358908	140358908	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:140358908C>T	ENST00000406427.1	-	27	3376	c.3039_splice	c.e27-1	p.G1014_splice	PNPLA7_ENST00000277531.4_Splice_Site_p.G989_splice|PNPLA7_ENST00000492278.1_5'UTR|PNPLA7_ENST00000371457.1_Splice_Site_p.G595_splice	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	989	Patatin.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GACGTCATGCCCTGGGGCCAC	0.602000													100	14					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57290105	57290105	+	Missense_Mutation	SNP	T	T	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:57290105T>G	ENST00000543872.2	+	4	2185	c.1921T>G	c.(1921-1923)Tgt>Ggt	p.C641G	SMG8_ENST00000300917.5_Missense_Mutation_p.C641G|SMG8_ENST00000580498.1_3'UTR|CTD-2510F5.6_ENST00000577660.1_Intron			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	641					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						GGAAGAAAAGTGTTGTGGAAA	0.338000													82	147					0	0	1	0	0
ANGPT1	284	broad.mit.edu	37	8	108334292	108334292	+	Missense_Mutation	SNP	C	C	T	rs149379021		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:108334292C>T	ENST00000520734.1	-	3	325	c.40G>A	c.(40-42)Gaa>Aaa	p.E14K	ANGPT1_ENST00000520052.1_Missense_Mutation_p.E14K			Q15389	ANGP1_HUMAN	angiopoietin 1	214					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding	p.E214K(1)		NS(1)|breast(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(13)|ovary(4)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	43	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TCTTTCTCTTCCTTTAAGGTG	0.353000													47	48					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195517473	195517473	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:195517473C>T	ENST00000463781.3	-	2	1437	c.978G>A	c.(976-978)caG>caA	p.Q326Q	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Silent_p.Q326Q|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	331					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CGCTCTGAGTCTGGTGGTTCT	0.458000													62	95					0	0	1	0	0
DOK4	55715	broad.mit.edu	37	16	57509062	57509062	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:57509062C>T	ENST00000566936.1	-	4	656	c.359G>A	c.(358-360)aGt>aAt	p.S120N	DOK4_ENST00000561918.1_5'UTR|DOK4_ENST00000340099.4_Missense_Mutation_p.S120N|DOK4_ENST00000569548.1_Missense_Mutation_p.S120N			Q8TEW6	DOK4_HUMAN	docking protein 4	120							insulin receptor binding			kidney(1)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(2)	6						TTCTCCCAGACTGATGTCGTT	0.602000													71	79					0	0	1	0	0
ANGPTL2	23452	broad.mit.edu	37	9	129870544	129870544	+	Missense_Mutation	SNP	G	G	A	rs145149714	by1000genomes	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:129870544G>A	ENST00000373425.3	-	2	1084	c.467C>T	c.(466-468)tCc>tTc	p.S156F	RALGPS1_ENST00000394022.3_Intron|RALGPS1_ENST00000259351.5_Intron|RALGPS1_ENST00000373436.1_Intron|ANGPTL2_ENST00000373417.1_Intron|RALGPS1_ENST00000424082.2_Intron|RALGPS1_ENST00000373434.1_Intron	NM_012098.2	NP_036230.1	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2	156					multicellular organismal development|signal transduction	extracellular space	receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|urinary_tract(1)	18						CTCCAGCTGGGAGAGCTCCAA	0.602000													51	9					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26273949	26273949	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:26273949G>A	ENST00000335473.7	+	25	4498	c.4248G>A	c.(4246-4248)cgG>cgA	p.R1416R	MYO18B_ENST00000407587.2_Silent_p.R1417R|MYO18B_ENST00000536101.1_Silent_p.R1416R	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1416						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CGCTAAGACGGAAGCTAGAAA	0.478000													3	9					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28972152	28972152	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:28972152C>T	ENST00000359747.4	+	8	883	c.854C>T	c.(853-855)tCg>tTg	p.S285L	DSG4_ENST00000308128.4_Missense_Mutation_p.S285L|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	285	Cadherin 3.		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding	p.S285L(1)		NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TGTTTAAGTTCGGAACTGATA	0.338000													43	64					0	0	1	0	0
CLIP2	7461	broad.mit.edu	37	7	73811453	73811453	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:73811453C>T	ENST00000223398.6	+	14	3097	c.2770C>T	c.(2770-2772)Cca>Tca	p.P924S	CLIP2_ENST00000395060.1_Missense_Mutation_p.P924S|CLIP2_ENST00000361545.5_Missense_Mutation_p.P889S	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	924						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						TCGTCACTCCCCAGGGCCGGA	0.627000													32	52					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7070991	7070991	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:7070991G>A	ENST00000299481.4	+	6	2559	c.2213G>A	c.(2212-2214)gGg>gAg	p.G738E		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	738					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GACCTAAAAGGGAGTGATATA	0.383000													99	93					0	0	1	0	0
DIAPH3	81624	broad.mit.edu	37	13	60545101	60545101	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:60545101G>A	ENST00000400324.4	-	16	2064	c.1844C>T	c.(1843-1845)cCc>cTc	p.P615L	DIAPH3_ENST00000400319.1_Missense_Mutation_p.P545L|DIAPH3_ENST00000465066.1_5'UTR|DIAPH3_ENST00000400320.1_Missense_Mutation_p.P569L|DIAPH3_ENST00000377908.2_Missense_Mutation_p.P604L|DIAPH3_ENST00000400330.1_Missense_Mutation_p.P615L|DIAPH3_ENST00000267215.4_Missense_Mutation_p.P615L	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	615	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GAATCCCAGGGGAGGTGGTGG	0.537000													9	67					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247051698	247051698	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:247051698G>A	ENST00000366508.1	-	18	2507	c.2371C>T	c.(2371-2373)Cat>Tat	p.H791Y	AHCTF1_ENST00000326225.3_Missense_Mutation_p.H765Y|AHCTF1_ENST00000470300.1_5'UTR|AHCTF1_ENST00000391829.2_Missense_Mutation_p.H756Y			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	756	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			AAACCTACATGCAGACTAGCA	0.453000													39	48					0	0	1	0	0
TNFSF13B	10673	broad.mit.edu	37	13	108922766	108922766	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:108922766G>A	ENST00000375887.4	+	2	596	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K	TNFSF13B_ENST00000430559.1_Missense_Mutation_p.E140K|TNFSF13B_ENST00000479435.1_3'UTR|TNFSF13B_ENST00000542136.1_Missense_Mutation_p.E140K	NM_006573.4	NP_006564.1	Q9Y275	TN13B_HUMAN	tumor necrosis factor (ligand) superfamily, member 13b	140					cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding			large_intestine(1)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			GGGTCCAGAAGAAACAGGTAT	0.473000													41	65					0	0	1	0	0
RSG1	79363	broad.mit.edu	37	1	16558656	16558656	+	Missense_Mutation	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:16558656C>A	ENST00000375599.3	-	5	1083	c.664G>T	c.(664-666)Gct>Tct	p.A222S		NM_030907.3	NP_112169.2	Q9BU20	RSG1_HUMAN	REM2 and RAB-like small GTPase 1	222	Small GTPase-like.				cellular protein localization|cilium assembly|exocytosis|protein transport|regulation of exocytosis|regulation of vesicle fusion|small GTPase mediated signal transduction	cilium|microtubule basal body	GTP binding			large_intestine(2)|lung(2)|pancreas(1)|prostate(1)	6						GCCAGCCCAGCCCGCCCGTCC	0.697000													37	44					2.40579e-17	2.43084e-17	1	1	0
RBM48	84060	broad.mit.edu	37	7	92158880	92158880	+	Silent	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:92158880T>C	ENST00000481551.1	+	2	243	c.202T>C	c.(202-204)Tta>Cta	p.L68L	RBM48_ENST00000265732.5_Silent_p.L68L			Q5RL73	CG064_HUMAN	RNA binding motif protein 48	68							nucleotide binding										GCGATTCGCTTTATATGGTGC	0.343000													33	45					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102399	168102399	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:168102399C>T	ENST00000409195.1	+	9	4586	c.4497C>T	c.(4495-4497)ttC>ttT	p.F1499F	XIRP2_ENST00000295237.9_Silent_p.F1499F|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Silent_p.F1277F	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1324					actin cytoskeleton organization	cell junction	actin binding	p.F1499F(1)		NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATCGAACTTTCGATTCTATTA	0.388000													37	112					0	0	1	0	0
WDR62	284403	broad.mit.edu	37	19	36590396	36590396	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:36590396C>T	ENST00000401500.2	+	22	2651	c.2616C>T	c.(2614-2616)ccC>ccT	p.P872P	WDR62_ENST00000270301.7_Silent_p.P872P	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	872					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GCCAAGAGCCCCTCAAGACCA	0.612000													69	87					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754437	49754437	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:49754437G>A	ENST00000304801.3	-	1	616	c.464C>T	c.(463-465)tCc>tTc	p.S155F		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	155					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity	p.S155F(1)		autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					CCCTAGCTTGGAAAGTGATGC	0.498000													23	82					0	0	1	0	0
FAM131B	9715	broad.mit.edu	37	7	143057241	143057241	+	Splice_Site	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:143057241C>T	ENST00000443739.2	-	2	178	c.28_splice	c.e2-1	p.G10_splice	FAM131B_ENST00000409408.1_5'UTR|FAM131B_ENST00000409222.3_5'UTR|FAM131B_ENST00000409578.1_Splice_Site_p.G10_splice|FAM131B_ENST00000409346.1_5'UTR	NM_001031690.2|NM_001278297.1	NP_001026860.2|NP_001265226.1	Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	0										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					TCACCTCATTCCCTGAGGGGG	0.622000													11	14					0	0	1	0	0
FCRL6	343413	broad.mit.edu	37	1	159779228	159779228	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:159779228G>A	ENST00000321935.6	+	6	748	c.662G>A	c.(661-663)gGg>gAg	p.G221E	FCRL6_ENST00000392235.3_Missense_Mutation_p.G119E|FCRL6_ENST00000339348.5_Missense_Mutation_p.G214E|FCRL6_ENST00000368106.3_Missense_Mutation_p.G214E			Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	214	Ig-like C2-type 3.					integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					CTGCACCACGGGCCTGCTGAC	0.617000													36	43					0	0	1	0	0
SCGN	10590	broad.mit.edu	37	6	25652673	25652673	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:25652673C>T	ENST00000377961.2	+	1	210	c.42C>T	c.(40-42)gcC>gcT	p.A14A	SCGN_ENST00000334979.6_Silent_p.A14A	NM_006998.3	NP_008929.2	O76038	SEGN_HUMAN	secretagogin, EF-hand calcium binding protein	14	EF-hand 1.					extracellular region|transport vesicle membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						GCTTGGACGCCGCTGGCTTCT	0.612000													31	80					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688565	26688565	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:26688565C>T	ENST00000529632.2	+	2	484	c.288C>T	c.(286-288)atC>atT	p.I96I	SEZ6L_ENST00000404234.3_Silent_p.I96I|SEZ6L_ENST00000403121.1_5'UTR|SEZ6L_ENST00000360929.3_Silent_p.I96I|SEZ6L_ENST00000248933.6_Silent_p.I96I|SEZ6L_ENST00000343706.4_Silent_p.I96I|SEZ6L_ENST00000402979.1_5'UTR	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	96						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						ATCACGACATCCCAGCCCTGT	0.632000													16	15					0	0	1	0	0
ZNF205	7755	broad.mit.edu	37	16	3169792	3169792	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:3169792C>T	ENST00000382192.3	+	7	1336	c.1131C>T	c.(1129-1131)tcC>tcT	p.S377S	ZNF205_ENST00000219091.4_Silent_p.S377S|RP11-473M20.14_ENST00000576490.1_RNA|RP11-473M20.14_ENST00000575139.1_RNA	NM_001278158.1|NM_003456.2	NP_001265087.1|NP_003447.2	O95201	ZN205_HUMAN	zinc finger protein 205	377					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20						GCCACCACTCCACGCTGATTC	0.662000													91	78					0	0	1	0	0
CLDN4	1364	broad.mit.edu	37	7	73246094	73246094	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:73246094G>A	ENST00000435050.1	+	2	3243	c.563G>A	c.(562-564)cGc>cAc	p.R188H	CLDN4_ENST00000340958.2_Missense_Mutation_p.R188H|CLDN4_ENST00000431918.1_Missense_Mutation_p.R188H			O14493	CLD4_HUMAN	claudin 4	188					calcium-independent cell-cell adhesion	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity|transmembrane receptor activity			kidney(2)|lung(4)|urinary_tract(1)	7		Lung NSC(55;0.159)				TGTCCACCCCGCACAGACAAG	0.642000													58	65					0	0	1	0	0
CLIP2	7461	broad.mit.edu	37	7	73811452	73811452	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:73811452C>T	ENST00000223398.6	+	14	3096	c.2769C>T	c.(2767-2769)tcC>tcT	p.S923S	CLIP2_ENST00000395060.1_Silent_p.S923S|CLIP2_ENST00000361545.5_Silent_p.S888S	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	923						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						ATCGTCACTCCCCAGGGCCGG	0.632000													33	53					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179412599	179412599	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179412599C>T	ENST00000589042.1	-	339	93978	c.93754G>A	c.(93754-93756)Gaa>Aaa	p.E31252K	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E29611K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E22312K|TTN_ENST00000342992.6_Missense_Mutation_p.E28684K|TTN_ENST00000460472.2_Missense_Mutation_p.E22187K|TTN_ENST00000342175.6_Missense_Mutation_p.E22379K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29611							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCATTTCTTCCAGTTTCCAT	0.438000													50	33					0	0	1	0	0
ANPEP	290	broad.mit.edu	37	15	90328730	90328730	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:90328730C>T	ENST00000300060.6	-	21	3067	c.2754G>A	c.(2752-2754)ctG>ctA	p.L918L		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	918	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	TGAACTGCTCCAGCTGCCAGA	0.557000													70	90					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39895171	39895171	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:39895171G>A	ENST00000373186.4	-	1	284	c.147C>T	c.(145-147)ttC>ttT	p.F49F	MOCS1_ENST00000308559.7_Silent_p.F49F|MOCS1_ENST00000373195.3_Intron|MOCS1_ENST00000373188.2_Silent_p.F49F|MOCS1_ENST00000432280.2_Silent_p.F20F|MOCS1_ENST00000425303.2_Silent_p.F49F|MOCS1_ENST00000373175.4_Silent_p.F20F|MOCS1_ENST00000340692.5_Silent_p.F49F	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	49	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					GCTCCCGCAGGAACTGCCTCC	0.657000													6	35					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28194582	28194582	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:28194582C>T	ENST00000302326.4	-	1	2904	c.1950G>A	c.(1948-1950)tcG>tcA	p.S650S		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	650							binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						CGGGCAGACCCGAGCCGCCCA	0.736000			T	ETV6	"""AML, meningioma"""								4	4					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25886754	25886754	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:25886754G>A	ENST00000376351.3	+	11	2558	c.2199G>A	c.(2197-2199)atG>atA	p.M733I	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	733						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.M733I(1)		breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GAAAGAAGATGATCACAAACA	0.448000													96	27					0	0	1	0	0
KRTAP3-2	83897	broad.mit.edu	37	17	39155982	39155982	+	Silent	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:39155982A>G	ENST00000391587.1	-	1	156	c.124T>C	c.(124-126)Tta>Cta	p.L42L		NM_031959.2	NP_114165.1	Q9BYR7	KRA32_HUMAN	keratin associated protein 3-2	42	3 X 5 AA repeats of C-C-X(3).					keratin filament	structural molecule activity			endometrium(1)|large_intestine(1)|lung(1)	3		Breast(137;0.00043)				GGCTCCAGTAACCAAACTGTG	0.627000													36	58					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70505181	70505181	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:70505181G>A	ENST00000310961.5	+	22	3993	c.3575G>A	c.(3574-3576)gGa>gAa	p.G1192E	LRRC7_ENST00000035383.5_Missense_Mutation_p.G1187E|LRRC7_ENST00000415775.2_Missense_Mutation_p.G471E			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1187						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						GCTCAGGCGGGAAGTTTTCCG	0.493000													28	35					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55152070	55152070	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:55152070C>T	ENST00000257290.5	+	18	2833	c.2502C>T	c.(2500-2502)atC>atT	p.I834I	FIP1L1_ENST00000507166.1_Silent_p.I594I	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	834	Protein kinase.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TTGTGAAGATCTGTGACTTTG	0.507000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			85	91					0	0	1	0	0
MT-ND1	4535	broad.mit.edu	37	MT	4061	4061	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrM:4061C>T	ENST00000361390.2	+	1	755	c.755C>T	c.(754-756)cCt>cTt	p.252_252insL						mitochondrially encoded NADH dehydrogenase 1											breast(1)|endometrium(13)|kidney(17)|lung(2)|prostate(1)	34						CGCACTCTCCCCTGAACTCTA	0.438000													11	139					0	0	1	0	0
ODF2L	57489	broad.mit.edu	37	1	86847984	86847984	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:86847984G>A	ENST00000359242.3	-	7	846	c.565C>T	c.(565-567)Cta>Tta	p.L189L	ODF2L_ENST00000370567.1_Silent_p.L189L|ODF2L_ENST00000294678.2_Silent_p.L189L|ODF2L_ENST00000317336.7_Silent_p.L189L|ODF2L_ENST00000394731.1_Silent_p.L58L|ODF2L_ENST00000370566.3_Silent_p.L189L	NM_001007022.2	NP_001007023.2	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like	189						centrosome				endometrium(2)|kidney(2)|large_intestine(10)|lung(6)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	24				all cancers(265;0.0313)|Epithelial(280;0.0611)		TGGATCTGTAGTCGTTCATGT	0.294000													17	78					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50161585	50161585	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:50161585C>T	ENST00000360565.3	+	11	3992	c.3868C>T	c.(3868-3870)Ccc>Tcc	p.P1290S		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	1290	Necessary for interaction with the CTD domain of POLR2A.|Pro-rich.				mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		CCCCCCAGGGCCCCCACGGCC	0.706000													6	10					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30702494	30702494	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:30702494C>T	ENST00000256246.2	-	1	4114	c.4040G>A	c.(4039-4041)gGa>gAa	p.G1347E		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1347										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TGAAGATTCTCCCTCACTATC	0.408000													63	13					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27216676	27216676	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:27216676C>T	ENST00000230582.3	+	3	303	c.288C>T	c.(286-288)ttC>ttT	p.F96F	PRSS16_ENST00000421826.2_Intron	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	96					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						GACCCATATTCCTGCATCTAG	0.557000													11	58					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94747176	94747176	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:94747176G>A	ENST00000399300.2	-	3	1676	c.1463C>T	c.(1462-1464)tCt>tTt	p.S488F	RBM12B_ENST00000517700.1_Missense_Mutation_p.S488F|RBM12B_ENST00000520961.1_Intron	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	488							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GGACATCACAGAAAAATTTAC	0.408000													140	151					0	0	1	0	0
PTEN	5728	broad.mit.edu	37	10	89720671	89720671	+	Nonsense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:89720671G>A	ENST00000371953.3	+	8	2179	c.822G>A	c.(820-822)tgG>tgA	p.W274*	PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	274	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.R55fs*1(5)|p.W274*(3)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.W274_F341del(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TTCACTTTTGGGTAAATACAT	0.269000		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			28	6					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17428444	17428444	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:17428444G>A	ENST00000302539.4	-	25	3281	c.3156C>T	c.(3154-3156)tcC>tcT	p.S1052S	ABCC8_ENST00000389817.3_Silent_p.S1051S	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1051	ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CCTGGCTGAGGGAGCAGTTCC	0.642000													44	63					0	0	1	0	0
CD300LF	146722	broad.mit.edu	37	17	72691365	72691365	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:72691365G>A	ENST00000326165.6	-	7	854	c.743C>T	c.(742-744)tCc>tTc	p.S248F	CD300LF_ENST00000301573.9_3'UTR|CD300LF_ENST00000464910.1_Missense_Mutation_p.S251F|CD300LF_ENST00000469092.1_3'UTR|RAB37_ENST00000340415.3_Intron|CD300LF_ENST00000361254.4_3'UTR|RAB37_ENST00000402449.4_Intron|CD300LF_ENST00000583937.1_Missense_Mutation_p.S263F|CD300LF_ENST00000343125.4_3'UTR	NM_139018.3	NP_620587.2	Q8TDQ1	CLM1_HUMAN	CD300 molecule-like family member f	248						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						AGATGCATAGGAAATGTCCTC	0.637000													30	53					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95511668	95511668	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:95511668C>T	ENST00000297591.5	-	17	4239	c.4164G>A	c.(4162-4164)aaG>aaA	p.K1388K	KIAA1429_ENST00000437199.1_Intron	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1388					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CTCCTGTGTCCTTACTAAATG	0.318000													16	34					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15740003	15740003	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:15740003G>A	ENST00000441682.2	+	0	1459							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						TGGCCCCCAGGAACTGCATCG	0.667000													8	18					0	0	1	0	0
CYP3A5	1577	broad.mit.edu	37	7	99270229	99270229	+	Missense_Mutation	SNP	A	A	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:99270229A>T	ENST00000343703.5	-	5	648	c.262T>A	c.(262-264)Tgt>Agt	p.C88S	CYP3A5_ENST00000480723.1_5'UTR|CYP3A5_ENST00000439761.1_Missense_Mutation_p.C98S|CYP3A5_ENST00000339843.2_3'UTR|CYP3A5_ENST00000222982.4_Missense_Mutation_p.C98S					cytochrome P450, family 3, subfamily A, polypeptide 5											NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)					ACAGAATAACATTCTTTCACT	0.368000													81	97					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42227360	42227360	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:42227360G>A	ENST00000541110.1	-	9	2614	c.2046C>T	c.(2044-2046)ttC>ttT	p.F682F	TRERF1_ENST00000372917.4_Silent_p.F579F|TRERF1_ENST00000354325.2_Silent_p.F579F|TRERF1_ENST00000372922.4_Silent_p.F662F|TRERF1_ENST00000340840.2_Silent_p.F579F			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	662	Interacts with CREBBP.|Pro-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GCGGCGGGATGAAGAGAGGTT	0.667000													29	95					0	0	1	0	0
SRPK1	6732	broad.mit.edu	37	6	35840461	35840461	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:35840461G>A	ENST00000373825.2	-	8	915	c.630C>T	c.(628-630)atC>atT	p.I210I	SRPK1_ENST00000423325.2_Silent_p.I194I|SRPK1_ENST00000373822.1_Silent_p.I103I			Q96SB4	SRPK1_HUMAN	SRSF protein kinase 1	210	Protein kinase.			I -> T (in Ref. 4; AAH38292).	cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(10)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21						TGTCAGTGTGGATGATACGGC	0.443000													10	16					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83129150	83129150	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:83129150G>A	ENST00000329312.4	+	4	1471	c.1434G>A	c.(1432-1434)aaG>aaA	p.K478K		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	478					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						AGGATGCAAAGAAAAATGCAG	0.353000													21	1					0	0	1	0	0
LPAR4	2846	broad.mit.edu	37	X	78011008	78011008	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:78011008C>T	ENST00000435339.2	+	2	1047	c.642C>T	c.(640-642)atC>atT	p.I214I	LPAR4_ENST00000373301.2_Silent_p.I214I	NM_005296.2	NP_005287.1	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	214						integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			breast(3)|endometrium(3)|kidney(4)|large_intestine(4)|lung(16)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	38						TTGGGTTTATCATTCCTCTAA	0.398000													28	4					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131848648	131848648	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:131848648G>A	ENST00000286355.5	-	12	4642	c.2550C>T	c.(2548-2550)ttC>ttT	p.F850F	ADCY8_ENST00000377928.3_Silent_p.F719F	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	850					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TCAGCCGGAGGAAAACTGCAC	0.547000										HNSCC(32;0.087)			64	65					0	0	1	0	0
FERMT2	10979	broad.mit.edu	37	14	53348116	53348116	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:53348116G>A	ENST00000395631.2	-	5	814	c.598C>T	c.(598-600)Ccc>Tcc	p.P200S	FERMT2_ENST00000341590.3_Missense_Mutation_p.P200S|FERMT2_ENST00000343279.4_Missense_Mutation_p.P200S|FERMT2_ENST00000553373.1_Missense_Mutation_p.P200S|FERMT2_ENST00000399304.3_Missense_Mutation_p.P200S			Q96AC1	FERM2_HUMAN	fermitin family member 2	200	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding	p.P200S(1)	ERO1L/FERMT2(2)	NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Breast(41;0.0342)					GGTGACAAGGGGCTTCCATCA	0.418000													68	58					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107041010	107041010	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:107041010G>A	ENST00000409886.3	-	20	3500	c.3413C>T	c.(3412-3414)tCt>tTt	p.S1138F	RGPD3_ENST00000304514.7_Missense_Mutation_p.S1138F	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1138	RanBD1 1.				intracellular transport		binding	p.S1138Y(2)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						ATCACCATCAGAGAAATCACT	0.448000													113	85					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131190990	131190990	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:131190990C>T	ENST00000337057.3	-	15	2501	c.2320G>A	c.(2320-2322)Gaa>Aaa	p.E774K	EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000531410.1_Intron|EPB41L2_ENST00000524581.1_Missense_Mutation_p.E152K|EPB41L2_ENST00000529208.1_Missense_Mutation_p.E704K|EPB41L2_ENST00000530757.1_Intron|EPB41L2_ENST00000527659.1_Missense_Mutation_p.E704K|EPB41L2_ENST00000368128.2_Missense_Mutation_p.E774K|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000527411.1_Missense_Mutation_p.E704K|EPB41L2_ENST00000528282.1_Intron|EPB41L2_ENST00000525193.1_Intron|EPB41L2_ENST00000530481.1_Missense_Mutation_p.E704K|EPB41L2_ENST00000445890.2_Intron	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	774					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		ACCTCTTCTTCATACTCCTGT	0.612000													81	86					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43702403	43702403	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:43702403G>A	ENST00000405312.3	-	3	692	c.455C>T	c.(454-456)tCc>tTc	p.S152F	PSG4_ENST00000433626.2_Intron|PSG4_ENST00000244295.9_Missense_Mutation_p.S152F	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	152	Ig-like C2-type 1.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				GTTGCTGCTGGAGATGGAGGG	0.512000													111	148					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28713941	28713941	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:28713941C>T	ENST00000257197.3	-	13	2290	c.2029G>A	c.(2029-2031)Gat>Aat	p.D677N	DSC1_ENST00000257198.5_Missense_Mutation_p.D677N|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	677	Cadherin 5.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GTACTTTTATCCTTCATTCTA	0.353000													50	90					0	0	1	0	0
STAM	8027	broad.mit.edu	37	10	17750894	17750894	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:17750894C>T	ENST00000377524.3	+	13	1544	c.1329C>T	c.(1327-1329)gtC>gtT	p.V443V	STAM_ENST00000540523.1_Silent_p.V332V	NM_003473.3	NP_003464.1	Q92783	STAM1_HUMAN	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	443					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	26						AGGCAGTGGTCCCACCATCCG	0.547000													64	10					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162459366	162459366	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:162459366C>T	ENST00000306100.5	-	10	1700	c.1264G>A	c.(1264-1266)Gat>Aat	p.D422N	FSTL5_ENST00000427802.2_Missense_Mutation_p.D421N|FSTL5_ENST00000379164.4_Missense_Mutation_p.D421N|FSTL5_ENST00000536695.1_Missense_Mutation_p.D421N	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	422	Ig-like 2.					extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ATGTCTTCATCCACTCCTGCT	0.423000													79	115					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117730798	117730798	+	Missense_Mutation	SNP	G	G	A	rs150941257		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:117730798G>A	ENST00000368508.3	-	4	434	c.236C>T	c.(235-237)tCg>tTg	p.S79L	ROS1_ENST00000368507.3_Missense_Mutation_p.S88L|GOPC_ENST00000467125.1_Intron	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	79					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AACCTCACACGACTCCCGCTG	0.468000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								13	22					0	0	1	0	0
CAPN11	11131	broad.mit.edu	37	6	44137169	44137169	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:44137169C>T	ENST00000542245.1	+	3	278	c.240C>T	c.(238-240)ttC>ttT	p.F80F	CAPN11_ENST00000398776.1_Silent_p.F80F			Q9UMQ6	CAN11_HUMAN	calpain 11	80	Calpain catalytic.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	36	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGGAGCTCTTCGAGGACCCCT	0.587000													7	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615146	179615146	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179615146G>A	ENST00000360870.5	-	46	12203	c.11981C>T	c.(11980-11982)tCg>tTg	p.S3994L	TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000578746.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9810							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTTCCAACGAATGAATGAT	0.323000													28	83					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6078218	6078218	+	Missense_Mutation	SNP	C	C	T	rs146180696	byFrequency	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:6078218C>T	ENST00000217289.4	-	7	1698	c.910G>A	c.(910-912)Gaa>Aaa	p.E304K	FERMT1_ENST00000536936.1_Missense_Mutation_p.E47K	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	304	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						CAATCAATTTCTTCTAAGAGA	0.413000													48	70					0	0	1	0	0
FCRL1	115350	broad.mit.edu	37	1	157772254	157772254	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:157772254T>A	ENST00000358292.3	-	4	571	c.520A>T	c.(520-522)Agg>Tgg	p.R174W	FCRL1_ENST00000491942.1_Missense_Mutation_p.R174W|FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000368176.3_Missense_Mutation_p.R174W	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	174	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TCACTCTCCCTCACTGAAGGA	0.483000													46	57					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181700323	181700323	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:181700323G>A	ENST00000357570.5	+	19	2418	c.2106G>A	c.(2104-2106)agG>agA	p.R702R	CACNA1E_ENST00000367570.1_Silent_p.R751R|CACNA1E_ENST00000367567.4_Silent_p.R358R|CACNA1E_ENST00000360108.3_Intron|CACNA1E_ENST00000358338.5_Intron|CACNA1E_ENST00000526775.1_Intron|CACNA1E_ENST00000367573.2_Silent_p.R751R			Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	751					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GAGACAGAAGGAGAAGACACC	0.537000													20	31					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85546801	85546801	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:85546801G>A	ENST00000393217.2	+	21	4480		c.e21-1			NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TTTGTGAAAAGATTCCTGGAA	0.294000													32	21					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23706574	23706574	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:23706574C>T	ENST00000256797.4	-	15	2059	c.1891G>A	c.(1891-1893)Gga>Aga	p.G631R	ERN2_ENST00000457008.2_Missense_Mutation_p.G531R	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	583	Protein kinase.				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AACTGGGGTCCCCGCTCGGTG	0.637000													39	25					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45262624	45262624	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:45262624G>A	ENST00000303230.4	-	8	2129	c.2072C>T	c.(2071-2073)tCa>tTa	p.S691L		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	691						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CAGGATGGCTGATGGCTGGGG	0.637000													23	20					0	0	1	0	0
POMP	51371	broad.mit.edu	37	13	29246530	29246530	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:29246530G>A	ENST00000380842.4	+	5	400	c.319G>A	c.(319-321)Ggt>Agt	p.G107S	POMP_ENST00000460403.1_3'UTR	NM_015932.5	NP_057016.1	Q9Y244	POMP_HUMAN	proteasome maturation protein	107					proteasome assembly	cytosol|endoplasmic reticulum|membrane|microsome|nucleus|proteasome complex				endometrium(2)|kidney(1)|large_intestine(1)	4		Lung SC(185;0.0367)		all cancers(112;0.141)|OV - Ovarian serous cystadenocarcinoma(117;0.216)		TGTTTTGAGGGGTAATGATGA	0.388000													16	117					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141802458	141802458	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:141802458G>A	ENST00000475668.2	+	69	8046	c.7992G>A	c.(7990-7992)ttG>ttA	p.L2664L	MGAM_ENST00000549489.2_Silent_p.L1768L			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1768					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TCTATTACTTGGCCAGCTTTT	0.413000													17	19					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143996128	143996128	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:143996128G>A	ENST00000323110.2	-	4	794	c.792C>T	c.(790-792)ttC>ttT	p.F264F		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	264					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CACCGTACTGGAAGATGCAGT	0.607000									Familial Hyperaldosteronism type I				17	17					0	0	1	0	0
TNPO1	3842	broad.mit.edu	37	5	72201150	72201150	+	Missense_Mutation	SNP	T	T	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:72201150T>A	ENST00000337273.5	+	24	3036	c.2610T>A	c.(2608-2610)aaT>aaA	p.N870K	TNPO1_ENST00000454282.1_Missense_Mutation_p.N820K|TNPO1_ENST00000506351.2_Missense_Mutation_p.N862K|TNPO1_ENST00000523768.1_Missense_Mutation_p.N820K	NM_002270.3	NP_002261.3	Q92973	TNPO1_HUMAN	transportin 1	870					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(6)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	36		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		GATTTAAAAATCAAGTTGGCG	0.353000													37	79					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21826269	21826269	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:21826269C>T	ENST00000328843.6	+	60	9677	c.9646C>T	c.(9646-9648)Ccc>Tcc	p.P3216S	DNAH11_ENST00000409508.3_Missense_Mutation_p.P3209S			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3216	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GAAAGCCTTTCCCAACCCTCC	0.512000									Kartagener syndrome				51	69					0	0	1	0	0
SPNS3	201305	broad.mit.edu	37	17	4352618	4352618	+	Missense_Mutation	SNP	G	G	A	rs151081415	byFrequency	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:4352618G>A	ENST00000355530.2	+	7	1139	c.859G>A	c.(859-861)Gag>Aag	p.E287K	SPNS3_ENST00000333476.2_Missense_Mutation_p.E160K|SPNS3_ENST00000576069.1_Intron	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	287					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						GTTTCTGCTCGAGGCACGCGT	0.677000													59	63					0	0	1	0	0
SLC36A2	153201	broad.mit.edu	37	5	150696403	150696403	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:150696403G>A	ENST00000335244.4	-	10	1556	c.1427C>T	c.(1426-1428)tCc>tTc	p.S476F	SLC36A2_ENST00000450886.1_Missense_Mutation_p.S200F	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	476					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTGGAGTTGGAAAAGGGGTG	0.493000													38	25					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138442227	138442227	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:138442227C>T	ENST00000344876.4	-	4	3750	c.3364G>A	c.(3364-3366)Gtg>Atg	p.V1122M	PCDH18_ENST00000511115.1_Missense_Mutation_p.V302M|PCDH18_ENST00000412923.2_Missense_Mutation_p.V1121M|PCDH18_ENST00000510305.1_Missense_Mutation_p.V333M|PCDH18_ENST00000507846.1_Missense_Mutation_p.V901M	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	1122	Interaction with DAB1 (By similarity).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					ATCTCTGCCACCAGTTCACTG	0.423000													24	28					0	0	1	0	0
TTLL10	254173	broad.mit.edu	37	1	1115515	1115515	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:1115515C>T	ENST00000379290.1	+	6	474	c.301C>T	c.(301-303)Ctg>Ttg	p.L101L	TTLL10_ENST00000379288.3_Silent_p.L28L|TTLL10_ENST00000379289.1_Silent_p.L101L			Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	101					protein modification process		ATP binding|tubulin-tyrosine ligase activity			haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TGGGCCGGACCTGGAGGGGGC	0.692000													9	18					0	0	1	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95107114	95107114	+	RNA	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:95107114C>T	ENST00000469935.1	+	0	53					NR_015340.1																						tgagtgtgctccgtgcatgat	0.592000													7	3					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58723113	58723113	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:58723113G>A	ENST00000300079.5	+	7	665	c.615G>A	c.(613-615)ctG>ctA	p.L205L	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_Silent_p.L174L	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	174						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	ATGCCCAGCTGGATGTCTCTT	0.458000													37	66					0	0	1	0	0
C16orf46	123775	broad.mit.edu	37	16	81095088	81095088	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:81095088G>A	ENST00000378611.4	-	3	981	c.866C>T	c.(865-867)tCc>tTc	p.S289F	RP11-303E16.8_ENST00000564536.1_RNA|C16orf46_ENST00000299578.5_Missense_Mutation_p.S289F	NM_001100873.1	NP_001094343.1	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46	289										NS(1)|endometrium(2)|large_intestine(3)|lung(9)|prostate(1)|stomach(1)|urinary_tract(1)	18						GGTCAGCAGGGATATCTGGGC	0.582000													78	74					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179427731	179427731	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:179427731C>T	ENST00000589042.1	-	326	83352	c.83128G>A	c.(83128-83130)Gaa>Aaa	p.E27710K	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E26069K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E18770K|TTN_ENST00000342992.6_Missense_Mutation_p.E25142K|TTN_ENST00000460472.2_Missense_Mutation_p.E18645K|TTN_ENST00000342175.6_Missense_Mutation_p.E18837K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	26069	Fibronectin type-III 102.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGCCTTTTCCCATTTAACT	0.453000													125	78					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67800231	67800231	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:67800231G>A	ENST00000544246.1	-	2	3033	c.2342C>T	c.(2341-2343)gCc>gTc	p.A781V	PCDH9_ENST00000377865.2_Missense_Mutation_p.A781V|PCDH9_ENST00000456367.1_Missense_Mutation_p.A781V|PCDH9_ENST00000377861.3_Missense_Mutation_p.A781V|PCDH9_ENST00000328454.5_Missense_Mutation_p.A781V	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	781	Cadherin 7.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GATATAGGAGGCATTTCCAGC	0.463000													124	77					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	482707	482707	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:482707C>T	ENST00000264938.3	-	7	1321	c.1312G>A	c.(1312-1314)Gtc>Atc	p.V438I	SLC9A3_ENST00000514375.1_Missense_Mutation_p.V438I	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	438						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GTGGTGCTGACGAACAGGTTC	0.652000													22	31					0	0	1	0	0
BRAP	8315	broad.mit.edu	37	12	112119504	112119504	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:112119504G>A	ENST00000419234.4	-	3	573	c.380C>T	c.(379-381)tCa>tTa	p.S127L	BRAP_ENST00000327551.6_Missense_Mutation_p.S97L|BRAP_ENST00000539060.1_5'UTR	NM_006768.3	NP_006759.3	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	127					MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	20						ACTGAAGAATGAAATCTGGTC	0.418000													46	28					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137653805	137653805	+	Missense_Mutation	SNP	C	C	T	rs149912828		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:137653805C>T	ENST00000371817.3	+	19	2384	c.1970C>T	c.(1969-1971)cCg>cTg	p.P657L		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	657	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCAGGACCTCCGGGAGACGAT	0.597000													55	12					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12642635	12642635	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:12642635C>T	ENST00000425538.1	+	7	907	c.707C>T	c.(706-708)gCt>gTt	p.A236V	MYOCD_ENST00000395988.1_Missense_Mutation_p.A140V|MYOCD_ENST00000343344.4_Missense_Mutation_p.A236V	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	236					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GCCGTGCATGCTGCTGTAAAG	0.582000													43	39					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33154460	33154460	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:33154460G>A	ENST00000341947.2	-	5	969	c.742C>T	c.(742-744)Cca>Tca	p.P248S	COL11A2_ENST00000357486.1_Missense_Mutation_p.P248S|COL11A2_ENST00000361917.1_Missense_Mutation_p.P248S|COL11A2_ENST00000395194.1_Missense_Mutation_p.P248S|COL11A2_ENST00000374714.1_Missense_Mutation_p.P248S|COL11A2_ENST00000374713.1_Missense_Mutation_p.P248S|COL11A2_ENST00000374712.1_Missense_Mutation_p.P248S|COL11A2_ENST00000374708.4_Missense_Mutation_p.P248S|COL11A2_ENST00000395197.1_Missense_Mutation_p.P248S	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	248	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TGCTGCTGTGGAGATCTCTGG	0.572000													67	81					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101624273	101624273	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:101624273A>G	ENST00000311812.2	-	7	716	c.566T>C	c.(565-567)cTt>cCt	p.L189P	SNX31_ENST00000428383.2_Missense_Mutation_p.L90P	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	189					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			AGAACTTCCAAGACTAACATA	0.433000													54	39					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13768457	13768457	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:13768457G>A	ENST00000279593.3	-	6	1679	c.1470C>T	c.(1468-1470)atC>atT	p.I490I		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	490					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGGTTCCATTGATTTTCTTCC	0.373000													93	50					0	0	1	0	0
SOS2	6655	broad.mit.edu	37	14	50619804	50619804	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:50619804G>A	ENST00000216373.5	-	13	2419	c.2145C>T	c.(2143-2145)ttC>ttT	p.F715F	SOS2_ENST00000543680.1_Silent_p.F682F	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	715	N-terminal Ras-GEF.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					CACTTGAAATGAAGGATTCTA	0.289000													49	49					0	0	1	0	0
COPA	1314	broad.mit.edu	37	1	160261901	160261901	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:160261901G>A	ENST00000241704.7	-	29	3277	c.3048C>T	c.(3046-3048)ctC>ctT	p.L1016L	COPA_ENST00000368069.3_Silent_p.L1025L	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	1016					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CAACTGTGGTGAGCTGGTAGC	0.493000											OREG0013929	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	124	174					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166237144	166237144	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:166237144C>T	ENST00000375437.2	+	24	4641	c.4351C>T	c.(4351-4353)Ctt>Ttt	p.L1451F	SCN2A_ENST00000283256.6_Missense_Mutation_p.L1451F|SCN2A_ENST00000375427.2_Missense_Mutation_p.L1451F|SCN2A_ENST00000357398.3_Missense_Mutation_p.L1451F	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1451					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GTACATGTATCTTTATTTTGT	0.289000													31	49					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113479873	113479873	+	Silent	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr13:113479873G>A	ENST00000487903.1	+	11	1090	c.1002G>A	c.(1000-1002)gaG>gaA	p.E334E	ATP11A_ENST00000375630.2_Silent_p.E334E|ATP11A_ENST00000375645.3_Silent_p.E334E|ATP11A_ENST00000283558.8_Silent_p.E334E			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	334					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				AGAAAACGGAGTCGGAAAGGC	0.468000													10	64					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136567284	136567284	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:136567284G>A	ENST00000264162.2	-	8	2643	c.2633C>T	c.(2632-2634)tCc>tTc	p.S878F		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	878	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		TTTAGCCTTGGAGGGCACCTC	0.502000													82	98					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371668	240371668	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:240371668C>T	ENST00000319653.9	+	5	3786	c.3556C>T	c.(3556-3558)Cct>Tct	p.P1186S		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1186	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GGGAATACCTCCTCCGCCCCC	0.682000													13	18					0	0	1	0	0
ZFP91	80829	broad.mit.edu	37	11	58384275	58384275	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:58384275G>A	ENST00000316059.6	+	10	1360	c.1189G>A	c.(1189-1191)Gag>Aag	p.E397K	ZFP91-CNTF_ENST00000389919.4_Missense_Mutation_p.E397K	NM_001197051.1|NM_053023.4	NP_001183980.1|NP_444251.1	Q96JP5	ZFP91_HUMAN	ZFP91 zinc finger protein	397					activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	26		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				TCACACTGGCGAGAAGCCATT	0.423000													26	36					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897029	175897029	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:175897029C>T	ENST00000359240.3	+	5	1023	c.353C>T	c.(352-354)aCc>aTc	p.T118I	ADAM29_ENST00000404450.4_Missense_Mutation_p.T118I|ADAM29_ENST00000445694.1_Missense_Mutation_p.T118I|ADAM29_ENST00000514159.1_Missense_Mutation_p.T118I	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	118					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TCCCTCAGTACCTGTTTTGGG	0.438000													29	53					0	0	1	0	0
WNT9A	7483	broad.mit.edu	37	1	228111913	228111913	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:228111913C>T	ENST00000272164.5	-	3	551	c.541G>A	c.(541-543)Gaa>Aaa	p.E181K	WNT9A_ENST00000497852.1_Intron	NM_003395.2	NP_003386.1	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family, member 9A	181					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Prostate(94;0.0405)				CCCAGGAATTCCTTGACGAAC	0.622000													76	109					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218712673	218712673	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:218712673G>A	ENST00000171887.4	-	17	2644	c.2192C>T	c.(2191-2193)tCc>tTc	p.S731F	TNS1_ENST00000430930.1_Missense_Mutation_p.S731F|TNS1_ENST00000419504.1_Missense_Mutation_p.S731F	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	731						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GACACTCTGGGACTTGTGTAG	0.617000													50	36					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2290832	2290832	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:2290832C>T	ENST00000381458.5	+	3	253	c.190C>T	c.(190-192)Ccc>Tcc	p.P64S		NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	64					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	AGGGCCTTACCCCTCAGAGTC	0.547000													57	102					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100678057	100678057	+	Silent	SNP	C	C	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:100678057C>A	ENST00000306151.4	+	3	3424	c.3360C>A	c.(3358-3360)acC>acA	p.T1120T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1120	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AGGCTAGCACCCTTTCCACAA	0.517000													114	925					4.34595e-34	4.41416e-34	1	1	0
CUZD1	50624	broad.mit.edu	37	10	124600703	124600703	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr10:124600703G>A	ENST00000368904.1	-	4	1173	c.224C>T	c.(223-225)tCc>tTc	p.S75F	CUZD1_ENST00000545804.1_Missense_Mutation_p.S75F|CUZD1_ENST00000392790.1_Missense_Mutation_p.S75F			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	75	CUB 1.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		CTGGACATAGGAAAAGATAAT	0.438000													26	8					0	0	1	0	0
GOLGA8EP	390535	broad.mit.edu	37	15	23444038	23444038	+	RNA	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:23444038G>A	ENST00000526079.1	+	0	1682					NR_027407.1|NR_033350.1																						ACAGTGAGGGGGAGGAGGCAC	0.612000													12	48					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102056169	102056169	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:102056169C>T	ENST00000549145.1	+	20	2130	c.2030C>T	c.(2029-2031)tCc>tTc	p.S677F	MYBPC1_ENST00000360610.2_Missense_Mutation_p.S664F|MYBPC1_ENST00000545503.2_Missense_Mutation_p.S664F|MYBPC1_ENST00000553190.1_Missense_Mutation_p.S664F|MYBPC1_ENST00000551300.1_Missense_Mutation_p.S565F|MYBPC1_ENST00000361685.2_Missense_Mutation_p.S689F|MYBPC1_ENST00000361466.2_Missense_Mutation_p.S689F|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000550270.1_Missense_Mutation_p.S664F|MYBPC1_ENST00000547509.1_Missense_Mutation_p.S650F|MYBPC1_ENST00000547405.1_Missense_Mutation_p.S638F|MYBPC1_ENST00000541119.1_Missense_Mutation_p.S652F|MYBPC1_ENST00000536007.1_Missense_Mutation_p.S645F|MYBPC1_ENST00000452455.2_Missense_Mutation_p.S664F|MYBPC1_ENST00000441232.1_Missense_Mutation_p.S664F|MYBPC1_ENST00000392934.3_Missense_Mutation_p.S651F			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	664	Fibronectin type-III 1.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						AAACAAAGCTCCAGGTGGATG	0.393000													7	34					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34094868	34094868	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:34094868C>T	ENST00000297161.2	+	10	1254	c.880C>T	c.(880-882)Ccc>Tcc	p.P294S	BMPER_ENST00000426693.1_Missense_Mutation_p.P294S	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	294					blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						CCTACGAGTGCCCCCAGAAGA	0.507000													76	91					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2783710	2783710	+	Missense_Mutation	SNP	A	A	G			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:2783710A>G	ENST00000399655.1	+	39	4995	c.4730A>G	c.(4729-4731)aAc>aGc	p.N1577S	CACNA1C_ENST00000399637.1_Missense_Mutation_p.N1596S|CACNA1C_ENST00000399597.1_Missense_Mutation_p.N1577S|CACNA1C_ENST00000399629.1_Missense_Mutation_p.N1594S|CACNA1C_ENST00000399621.1_Missense_Mutation_p.N1596S|CACNA1C_ENST00000399641.1_Missense_Mutation_p.N1577S|CACNA1C_ENST00000399638.1_Missense_Mutation_p.N1605S|CACNA1C_ENST00000399634.1_Missense_Mutation_p.N1577S|CACNA1C_ENST00000406454.3_Missense_Mutation_p.N1577S|CACNA1C_ENST00000399644.1_Missense_Mutation_p.N1577S|CACNA1C_ENST00000399595.1_Missense_Mutation_p.N1585S|CACNA1C_ENST00000399649.1_Missense_Mutation_p.N1583S|CACNA1C_ENST00000327702.7_Missense_Mutation_p.N1577S|CACNA1C_ENST00000399601.1_Missense_Mutation_p.N1577S|CACNA1C_ENST00000344100.3_Missense_Mutation_p.N1618S|CACNA1C_ENST00000399603.1_Missense_Mutation_p.N1577S|CACNA1C_ENST00000402845.3_Missense_Mutation_p.N1596S|CACNA1C_ENST00000347598.4_Missense_Mutation_p.N1625S|CACNA1C_ENST00000399591.1_Missense_Mutation_p.N1585S|CACNA1C_ENST00000335762.5_Missense_Mutation_p.N1602S|CACNA1C_ENST00000399617.1_Missense_Mutation_p.N1577S|CACNA1C_ENST00000399606.1_Missense_Mutation_p.N1597S	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1625					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CCTGCAGGGAACCTAGAACAA	0.612000													3	5					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104449092	104449092	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:104449092C>T	ENST00000361820.3	-	2	1690	c.1090G>A	c.(1090-1092)Gaa>Aaa	p.E364K		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	364					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GTCCTCAGTTCCTCCACATTC	0.512000													24	8					0	0	1	0	0
IL36B	27177	broad.mit.edu	37	2	113786574	113786574	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:113786574C>T	ENST00000259213.4	-	4	310	c.203G>A	c.(202-204)gGa>gAa	p.G68E	IL36B_ENST00000327407.2_Missense_Mutation_p.G68E	NM_014438.3	NP_055253.2	Q9NZH7	IL36B_HUMAN	interleukin 36, beta	68					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			kidney(1)|ovary(1)|pancreas(1)	3						GAGATCTTTTCCCTTGATTCC	0.418000													30	43					0	0	1	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213414585	213414585	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:213414585C>T	ENST00000366960.3	+	11	1916	c.1766C>T	c.(1765-1767)tCc>tTc	p.S589F	RPS6KC1_ENST00000543354.1_Missense_Mutation_p.S292F|RPS6KC1_ENST00000366959.3_Missense_Mutation_p.S577F|RPS6KC1_ENST00000543470.1_Missense_Mutation_p.S377F|RPS6KC1_ENST00000490299.1_3'UTR	NM_012424.3	NP_036556.2	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide 1	589					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		ACATCAGATTCCCTCAGTAGA	0.463000													24	28					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73014975	73014975	+	Missense_Mutation	SNP	T	T	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:73014975T>C	ENST00000261180.4	+	14	2518	c.2422T>C	c.(2422-2424)Tac>Cac	p.Y808H		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	808					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TCAAGCATCCTACCAACATGA	0.353000													7	49					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	124999970	124999970	+	Splice_Site	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:124999970G>A	ENST00000431078.1	+	3	745	c.381_splice	c.e3+1	p.W127_splice		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	127	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		ACAGCATCTGGGTAGGACATC	0.423000													10	9					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													4	124					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79032714	79032714	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr5:79032714C>T	ENST00000446378.2	+	2	8157	c.8126C>T	c.(8125-8127)cCt>cTt	p.P2709L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2709						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CAACCACGTCCTTTAGAAGAA	0.403000													32	20					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424653	125424653	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:125424653G>A	ENST00000373686.1	+	1	809	c.809G>A	c.(808-810)aGa>aAa	p.R270K				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						TCTTATTTAAGAATCCTCATC	0.423000													172	28					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129566555	129566555	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:129566555C>T	ENST00000422113.2	-	7	1998	c.1672G>A	c.(1672-1674)Gag>Aag	p.E558K	TMEM132D_ENST00000389441.4_Missense_Mutation_p.E96K	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	558						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCATCCTCCTCCTCTTCACTG	0.642000													16	57					0	0	1	0	0
SLC2A11	66035	broad.mit.edu	37	22	24210750	24210750	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:24210750C>T	ENST00000345044.6	+	3	471	c.203C>T	c.(202-204)tCc>tTc	p.S68F	SLC2A11_ENST00000403208.3_Missense_Mutation_p.S68F|SLC2A11_ENST00000398356.2_Missense_Mutation_p.S75F|SLC2A11_ENST00000316185.8_Missense_Mutation_p.S71F|SLC2A11_ENST00000467660.1_3'UTR|AP000350.10_ENST00000433835.3_Missense_Mutation_p.S33F|SLC2A11_ENST00000405847.1_Missense_Mutation_p.S68F			Q9BYW1	GTR11_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 11	68						integral to membrane|plasma membrane	sugar transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	12						CTTATGTGGTCCCTCATCGTG	0.562000													58	69					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153692027	153692027	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:153692027G>A	ENST00000369682.3	+	6	1716	c.1541G>A	c.(1540-1542)cGa>cAa	p.R514Q		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	514					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGTGTGCTGCGACACAGGTGA	0.731000													7	1					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50936947	50936947	+	Nonsense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:50936947C>T	ENST00000442544.2	+	20	3677	c.3061C>T	c.(3061-3063)Cga>Tga	p.R1021*	DCC_ENST00000581580.1_Nonsense_Mutation_p.R656*|DCC_ENST00000412726.1_Nonsense_Mutation_p.R849*	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1021	Fibronectin type-III 6.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GTATTACTTTCGAATTCAAGC	0.378000													39	11					0	0	1	0	0
TSC2	7249	broad.mit.edu	37	16	2129087	2129087	+	Silent	SNP	C	C	T	rs137854287		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:2129087C>T	ENST00000219476.3	+	27	3651	c.3021C>T	c.(3019-3021)tcC>tcT	p.S1007S	TSC2_ENST00000439673.2_Silent_p.S927S|TSC2_ENST00000401874.2_Silent_p.S963S|TSC2_ENST00000382538.6_Silent_p.S915S|TSC2_ENST00000568454.1_Silent_p.S974S|TSC2_ENST00000350773.4_Silent_p.S1007S|TSC2_ENST00000568366.1_3'UTR|TSC2_ENST00000353929.4_Silent_p.S964S	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	1007					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				ATGAGAACTCCGTGGCCCAGG	0.602000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				59	65					0	0	1	0	0
OR9A4	130075	broad.mit.edu	37	7	141618998	141618998	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr7:141618998G>A	ENST00000548136.1	+	1	382	c.323G>A	c.(322-324)gGg>gAg	p.G108E	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					CTTGCTGTGGGGACAACAGAG	0.493000													61	98					0	0	1	0	0
BRD1	23774	broad.mit.edu	37	22	50217205	50217205	+	Missense_Mutation	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr22:50217205C>T	ENST00000216267.8	-	1	1247	c.761G>A	c.(760-762)gGc>gAc	p.G254D	BRD1_ENST00000457780.2_Missense_Mutation_p.G254D|BRD1_ENST00000404760.1_Missense_Mutation_p.G254D|BRD1_ENST00000404034.1_Missense_Mutation_p.G254D	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	254					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GAGCCACTGGCCCTCGGGGAT	0.637000													52	29					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33293957	33293957	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:33293957G>A	ENST00000280979.4	+	13	7108	c.6938G>A	c.(6937-6939)cGa>cAa	p.R2313Q	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	2313					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CATGAAAAACGACATAGAAAT	0.413000													64	48					0	0	1	0	0
IGSF9	57549	broad.mit.edu	37	1	159897662	159897662	+	Silent	SNP	C	C	T			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:159897662C>T	ENST00000368094.1	-	20	3443	c.3246G>A	c.(3244-3246)gtG>gtA	p.V1082V	IGSF9_ENST00000493195.1_5'UTR|IGSF9_ENST00000361509.3_Silent_p.V1066V	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	1082						cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			AGTTCTCGTCCACAGATGTGT	0.488000													22	41					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363276	22363276	+	Missense_Mutation	SNP	G	G	A			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:22363276G>A	ENST00000397121.2	-	3	1560	c.1243C>T	c.(1243-1245)Cat>Tat	p.H415Y		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	415					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TCTCCAGTATGAATTCTCTTA	0.433000													48	57					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16945182	16945184	+	RNA	DEL	AAT	AAT	-	rs59197507		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr1:16945182_16945184delAAT	ENST00000412962.1	-	0	2335_2337																											TACTGATGAAAATAATAACAGAT	0.325													2	4	---	---	---	---					
LOC102724691	102724691	broad.mit.edu	37	2	105625936	105625936	+	RNA	DEL	T	T	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:105625936delT	ENST00000456519.1	-	0	43																											gatgaataactcaaatatctg	0.308													2	4	---	---	---	---					
RP11-105N14.2	0	broad.mit.edu	37	2	214135072	214135072	+	RNA	DEL	A	A	-	rs78003063		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr2:214135072delA	ENST00000606960.1	-	0	81																											actccgtctcaaaaaaaaaaa	0.398													2	4	---	---	---	---					
FAM157A	728262	broad.mit.edu	37	3	197895603	197895603	+	RNA	DEL	G	G	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr3:197895603delG	ENST00000437428.2	+	0	903							C9JC47	F157A_HUMAN												NS(1)|skin(1)	2						TCCACACCATGCCCTATCACT	0.408													2	4	---	---	---	---					
ADH5	128	broad.mit.edu	37	4	99996084	99996100	+	Frame_Shift_Del	DEL	CCATGTGCGACCTGTTA	CCATGTGCGACCTGTTA	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:99996084_99996100delCCATGTGCGACCTGTTA	ENST00000296412.8	-	7	976_992	c.926_942delTAACAGGTCGCACATGG	c.(925-942)gfs	p.VTGRTW309fs		NM_000671.3	NP_000662.3	P11766	ADHX_HUMAN	alcohol dehydrogenase 5 (class III), chi polypeptide	309			V -> I (in dbSNP:rs28730628).		ethanol oxidation|response to redox state		alcohol dehydrogenase (NAD) activity|electron carrier activity|fatty acid binding|formaldehyde dehydrogenase activity|S-(hydroxymethyl)glutathione dehydrogenase activity|zinc ion binding	p.T313T(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)	13				OV - Ovarian serous cystadenocarcinoma(123;2.5e-07)	NADH(DB00157)	CAGTGCCTTTCCATGTGCGACCTGTTACCAGCTGGAA	0.488													81	213	---	---	---	---					
ADH1C	126	broad.mit.edu	37	4	100264434	100264434	+	RNA	DEL	A	A	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr4:100264434delA	ENST00000515683.1	-	0	919				ADH1C_ENST00000510055.1_RNA	NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	tcatctggggagctttaaaaa	0.423													2	4	---	---	---	---					
RP1-223B1.1	0	broad.mit.edu	37	6	3617092	3617092	+	RNA	DEL	T	T	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:3617092delT	ENST00000443445.1	-	0	500																											aagagctctcttttgccactt	0.582													2	4	---	---	---	---					
LOC101928663	101928663	broad.mit.edu	37	6	25250394	25250395	+	RNA	DEL	TA	TA	-	rs9393631	by1000genomes	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr6:25250394_25250395delTA	ENST00000413898.2	-	0	635																											cttttttttttatttttgagat	0.450													2	4	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130474495	130474496	+	RNA	DEL	CC	CC	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr8:130474495_130474496delCC	ENST00000446592.3	-	0	360																											acgtgaccctccaggatcatgg	0.406													2	4	---	---	---	---					
LINC01410	103352539	broad.mit.edu	37	9	66458154	66458155	+	RNA	INS	-	-	C	rs142957926		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr9:66458154_66458155insC	ENST00000424345.1	+	0	67				RNA5SP283_ENST00000365604.1_RNA																							agcctacggtaccgctattacc	0.619													7	12	---	---	---	---					
ADM	133	broad.mit.edu	37	11	10328106	10328108	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:10328106_10328108delCGG	ENST00000528655.1	+	3	1093_1095	c.476_478delCGG	c.(475-480)cgt>c	p.PG159del	ADM_ENST00000278175.5_In_Frame_Del_p.PG159del|ADM_ENST00000530439.1_In_Frame_Del_p.PG91del|ADM_ENST00000525063.1_In_Frame_Del_p.PG159del|ADM_ENST00000534464.1_In_Frame_Del_p.PG112del			P35318	ADML_HUMAN	adrenomedullin	159					blood circulation|cAMP biosynthetic process|female pregnancy|negative regulation of vasoconstriction|progesterone biosynthetic process|response to wounding	cytoplasm|extracellular space|soluble fraction	hormone activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(1)	6				all cancers(16;3.51e-65)|Epithelial(150;1.52e-62)|BRCA - Breast invasive adenocarcinoma(625;0.0257)		gaggccggcccgggTCGGACTCT	0.655													25	29	---	---	---	---					
LOC101928989	101928989	broad.mit.edu	37	11	81919405	81919405	+	RNA	DEL	T	T	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr11:81919405delT	ENST00000500502.1	-	0	431																											cctatttttattatatttggt	0.358													2	4	---	---	---	---					
RP11-408B11.2	0	broad.mit.edu	37	12	85713278	85713278	+	RNA	DEL	C	C	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr12:85713278delC	ENST00000555596.1	+	0	78																											cccttcctctcccccctacat	0.547													2	4	---	---	---	---					
RP11-754I20.1	0	broad.mit.edu	37	14	19115150	19115151	+	RNA	INS	-	-	T	rs149486110	by1000genomes	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:19115150_19115151insT	ENST00000553170.1	+	0	245																											TTTCCCACCTGTTTTTTTTTTC	0.277													2	4	---	---	---	---					
MAP4K5	11183	broad.mit.edu	37	14	50930796	50930796	+	Frame_Shift_Del	DEL	T	T	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr14:50930796delT	ENST00000013125.4	-	12	1111	c.793delA	c.(793-795)gafs	p.R265fs		NM_006575.4|NM_198794.2	NP_006566.2|NP_942089.1	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase kinase 5	265	Protein kinase.				activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity	p.R265fs*8(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_epithelial(31;0.000415)|Breast(41;0.0102)					GCAGTTGGTCTTTTTTTTGGG	0.308													3	5	---	---	---	---					
B2M	567	broad.mit.edu	37	15	45003799	45003813	+	Splice_Site	DEL	GAGGCTATCCAGCGT	GAGGCTATCCAGCGT	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:45003799_45003813delGAGGCTATCCAGCGT	ENST00000558401.1	+	1	125_137	c.67_splice	c.e1+1	p.19_splice	B2M_ENST00000559916.1_Splice_Site_p.19_splice|B2M_ENST00000544417.1_Splice_Site_p.19_splice	NM_004048.2	NP_004039.1	P61769	B2MG_HUMAN	beta-2-microglobulin	19					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding	p.?(2)		breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		TTCTGGCCTGGAGGCTATCCAGCGTGAGTCTCTCC	0.628													36	12	---	---	---	---					
RP11-66B24.5	0	broad.mit.edu	37	15	101263087	101263087	+	RNA	DEL	A	A	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr15:101263087delA	ENST00000559755.1	+	0	123																											TCCCTAAGGGAAAAAAAAAAC	0.418													3	4	---	---	---	---					
CDH1	999	broad.mit.edu	37	16	68835626	68835627	+	Frame_Shift_Ins	INS	-	-	C			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr16:68835626_68835627insC	ENST00000261769.5	+	3	408_409	c.217_218insC	c.(217-219)ccgfs	p.P73fs	CDH1_ENST00000562836.1_3'UTR|CDH1_ENST00000422392.2_Frame_Shift_Ins_p.P73fs	NM_004360.3	NP_004351.1	P12830	CADH1_HUMAN	cadherin 1, type 1, E-cadherin (epithelial)	73					adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.?(2)		NS(6)|biliary_tract(8)|breast(161)|central_nervous_system(4)|endometrium(9)|kidney(4)|large_intestine(13)|lung(13)|oesophagus(3)|ovary(2)|prostate(3)|soft_tissue(2)|stomach(76)|thyroid(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	311		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TTCCCTCGACACCCGATTCAAA	0.465			"""Mis, N, F, S"""		"""lobular breast, gastric"""	gastric			Hereditary Diffuse Gastric Cancer				82	95	---	---	---	---					
FLJ36000	284124	broad.mit.edu	37	17	21909654	21909654	+	RNA	DEL	C	C	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:21909654delC	ENST00000581223.2	+	0	379					NR_027084.1																						GCACTTCGCACCCCTCCTGTT	0.582													2	4	---	---	---	---					
RP11-697E22.2	0	broad.mit.edu	37	17	36003614	36003615	+	RNA	DEL	TT	TT	-	rs10543338		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr17:36003614_36003615delTT	ENST00000586163.1	+	0	590				RP11-697E22.2_ENST00000586950.1_RNA																							ATTAtttatctttttttttttt	0.505													3	4	---	---	---	---					
CTD-2015H3.2	0	broad.mit.edu	37	18	1730321	1730322	+	RNA	INS	-	-	GGGATTAA	rs144546207	by1000genomes	TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:1730321_1730322insGGGATTAA	ENST00000580524.1	+	0	408																											ggggggccatggggattAAGAC	0.386													3	6	---	---	---	---					
DYM	54808	broad.mit.edu	37	18	46858341	46858341	+	Frame_Shift_Del	DEL	A	A	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr18:46858341delA	ENST00000269445.6	-	8	1113	c.656delT	c.(655-657)tafs	p.L219fs	DYM_ENST00000578396.1_Frame_Shift_Del_p.L64fs|DYM_ENST00000442713.2_Intron	NM_017653.3	NP_060123.3	Q7RTS9	DYM_HUMAN	dymeclin	219						Golgi apparatus				NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	18						AAAGTTATATAATAAGGTCTT	0.398													32	31	---	---	---	---					
SPPL2B	56928	broad.mit.edu	37	19	2348975	2348976	+	RNA	DEL	TC	TC	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr19:2348975_2348976delTC	ENST00000452401.2	+	0	1431				AC005258.3_ENST00000590001.1_RNA			Q8TCT7	PSL1_HUMAN	signal peptide peptidase like 2B							Golgi membrane|integral to membrane	aspartic-type endopeptidase activity						Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGATTCCGTTCTCTCTCCACA	0.520													3	5	---	---	---	---					
CRNKL1	51340	broad.mit.edu	37	20	20020266	20020266	+	Frame_Shift_Del	DEL	A	A	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:20020266delA	ENST00000377340.2	-	12	2046	c.2015delT	c.(2014-2016)tafs	p.L672fs	CRNKL1_ENST00000377327.4_Frame_Shift_Del_p.L660fs|CRNKL1_ENST00000536226.1_Frame_Shift_Del_p.L511fs	NM_001278628.1|NM_016652.4	NP_001265557.1|NP_057736.4	Q9BZJ0	CRNL1_HUMAN	crooked neck pre-mRNA splicing factor 1	672					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			breast(2)|cervix(2)|endometrium(7)|large_intestine(11)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(6)	45						TGGCATGTCTAAACGTGGCTG	0.378													76	103	---	---	---	---					
ADNP	23394	broad.mit.edu	37	20	49509856	49509856	+	Frame_Shift_Del	DEL	G	G	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr20:49509856delG	ENST00000396029.3	-	5	1962	c.1395delC	c.(1393-1395)ttfs	p.F465fs	ADNP_ENST00000396032.3_Frame_Shift_Del_p.F465fs|ADNP_ENST00000349014.3_Frame_Shift_Del_p.F465fs|ADNP_ENST00000371602.4_Frame_Shift_Del_p.F465fs	NM_015339.2	NP_056154.1	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector homeobox	465						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.F465F(1)		NS(1)|breast(4)|endometrium(7)|kidney(1)|large_intestine(13)|lung(7)|ovary(2)|prostate(2)|skin(2)	39						GTTCTTTTTCGAAGTGCACAC	0.388													167	207	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11058816	11058817	+	RNA	INS	-	-	AAC	rs151011637		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:11058816_11058817insAAC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTCACAAAAAAAAAACTACATA	0.277													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11065298	11065299	+	RNA	INS	-	-	AGC	rs56754608		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:11065298_11065299insAGC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ataacaaataGAGCAGCATTTC	0.337													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11065360	11065360	+	RNA	DEL	T	T	-	rs148837406		TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chr21:11065360delT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATTTTTAAGATTTTTTTTTAC	0.308													4	5	---	---	---	---					
MAGEB17	645864	broad.mit.edu	37	X	16188527	16188527	+	Frame_Shift_Del	DEL	A	A	-			TCGA-OD-A75X-06A-12D-A32N-08	TCGA-OD-A75X-10A-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c5aa9b-2524-4f8b-890a-4bddf7948fa6	f91db11c-f0d3-44b5-bb18-d650ef59558f	g.chrX:16188527delA	ENST00000400004.2	+	2	374	c.22delA	c.(22-24)agfs	p.K8fs	MAGEB17_ENST00000329538.5_Frame_Shift_Del_p.8fs|MAGEB17_ENST00000400003.1_Frame_Shift_Del_p.K8fs|RP11-431J24.2_ENST00000435789.1_RNA	NM_001277307.1	NP_001264236.1			melanoma antigen family B, 17																		TCAGGCGAGTAAGCGCCGTGC	0.627													2	4	---	---	---	---