Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NEUROG2	63973	broad.mit.edu	37	4	113436004	113436004	+	Missense_Mutation	SNP	G	G	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr4:113436004G>A	ENST00000313341.3	-	2	954	c.628C>T	c.(628-630)Ccc>Tcc	p.P210S		NM_024019.3	NP_076924.1	Q9H2A3	NGN2_HUMAN	neurogenin 2	210	Ser-rich.				positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent	nucleus	E-box binding			central_nervous_system(1)|large_intestine(3)|lung(6)|skin(2)	12		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00168)		GTGGAGGCGGGCGAGGGGCTG	0.721000													11	10					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73040894	73040894	+	RNA	SNP	T	T	G			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chrX:73040894T>G	ENST00000604411.1	+	0	28855				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						AGTTACTTTCTTCTTTCCATT	0.368000													21	10					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811099	140811099	+	Splice_Site	SNP	C	C	T			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr4:140811099C>T	ENST00000398940.1	-	1	107	c.108_splice	c.e1+1	p.Q36_splice	MAML3_ENST00000509479.2_Silent_p.Q497Q|MAML3_ENST00000327122.5_Silent_p.Q341Q			Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	497					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity	p.Q497Q(2)		breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.542000													3	42					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49735489	49735489	+	Silent	SNP	A	A	G			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr3:49735489A>G	ENST00000327697.6	+	7	546	c.402A>G	c.(400-402)aaA>aaG	p.K134K	RNF123_ENST00000432042.1_5'UTR	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	134	B30.2/SPRY.					cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		TTCCAGGGAAATGGCTCTACG	0.582000													28	55					0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198267483	198267483	+	Missense_Mutation	SNP	C	C	T			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr2:198267483C>T	ENST00000335508.5	-	14	1965	c.1874G>A	c.(1873-1875)cGt>cAt	p.R625H		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	625					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding	p.R625L(9)|p.R625P(2)|p.R625H(1)		NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGTTGTGTTACGGACATACTC	0.438000			Mis		myelodysplastic syndrome								22	25					0	0	1	0	0
NUDT22	84304	broad.mit.edu	37	11	63995065	63995065	+	Missense_Mutation	SNP	A	A	C			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr11:63995065A>C	ENST00000279206.3	+	3	662	c.506A>C	c.(505-507)cAg>cCg	p.Q169P	NUDT22_ENST00000441250.2_Intron	NM_001128612.2|NM_032344.2	NP_001122084.1|NP_115720.1	Q9BRQ3	NUD22_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 22	169	Nudix hydrolase.						hydrolase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)	8						GGCAGCCCCCAGCACCAGGAC	0.617000													24	37					0	0	1	0	0
STAP1	26228	broad.mit.edu	37	4	68424566	68424566	+	Silent	SNP	G	G	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr4:68424566G>A	ENST00000265404.2	+	1	121	c.39G>A	c.(37-39)agG>agA	p.R13R	STAP1_ENST00000396225.1_Silent_p.R13R	NM_012108.2	NP_036240.1	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	13					cellular membrane fusion|intracellular protein transport	cytoplasm				NS(1)|large_intestine(1)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	12						CCCCTCGCAGGATCTTCCAGG	0.428000													42	42					0	0	1	0	0
GPR97	222487	broad.mit.edu	37	16	57719755	57719755	+	Missense_Mutation	SNP	T	T	G			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr16:57719755T>G	ENST00000333493.4	+	11	1618	c.1457T>G	c.(1456-1458)gTg>gGg	p.V486G	GPR97_ENST00000450388.3_Missense_Mutation_p.V366G|GPR97_ENST00000327655.6_Missense_Mutation_p.V276G|RP11-405F3.4_ENST00000563062.1_RNA	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	486					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TCGAGCCTGGTGGGTGTGACA	0.602000													27	33					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153583052	153583052	+	Nonsense_Mutation	SNP	G	G	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chrX:153583052G>A	ENST00000422373.1	-	31	5469	c.5221C>T	c.(5221-5223)Cag>Tag	p.Q1741*	FLNA_ENST00000369856.3_5'UTR|FLNA_ENST00000360319.4_Nonsense_Mutation_p.Q1741*|FLNA_ENST00000344736.4_Intron|FLNA_ENST00000369850.3_Nonsense_Mutation_p.Q1749*	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1749	Hinge 1.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGAGGGGGCTGCACCGAGGGC	0.677000													3	14					0	0	1	0	0
RALGDS	5900	broad.mit.edu	37	9	135984119	135984119	+	Missense_Mutation	SNP	C	C	T			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr9:135984119C>T	ENST00000393160.3	-	5	907	c.554G>A	c.(553-555)cGt>cAt	p.R185H	RALGDS_ENST00000372050.3_Missense_Mutation_p.R240H|RALGDS_ENST00000542690.1_Missense_Mutation_p.R311H|RALGDS_ENST00000372062.3_Missense_Mutation_p.R211H|RALGDS_ENST00000393157.3_Missense_Mutation_p.R239H|RALGDS_ENST00000469972.1_5'UTR|RALGDS_ENST00000372047.3_Missense_Mutation_p.R228H	NM_001042368.1	NP_001035827.1	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	240	N-terminal Ras-GEF.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		AAGGTGGGCACGGCGCTCCAG	0.622000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								3	51					0	0	1	0	0
TEAD4	7004	broad.mit.edu	37	12	3103971	3103971	+	Nonsense_Mutation	SNP	G	G	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr12:3103971G>A	ENST00000359864.2	+	3	229	c.39G>A	c.(37-39)tgG>tgA	p.W13*	TEAD4_ENST00000358409.2_Nonsense_Mutation_p.W13*|TEAD4_ENST00000397122.2_Intron	NM_003213.3	NP_003204.2	Q15561	TEAD4_HUMAN	TEA domain family member 4	13					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			CCAACGAGTGGAGCTCTCCCA	0.662000													36	38					0	0	1	0	0
HBS1L	10767	broad.mit.edu	37	6	135287507	135287507	+	Missense_Mutation	SNP	C	C	T			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr6:135287507C>T	ENST00000367837.5	-	17	2209	c.2003G>A	c.(2002-2004)cGt>cAt	p.R668H	HBS1L_ENST00000367824.4_Missense_Mutation_p.R504H|HBS1L_ENST00000415177.2_Missense_Mutation_p.R603H|HBS1L_ENST00000445176.2_Missense_Mutation_p.R392H|HBS1L_ENST00000367826.2_Missense_Mutation_p.R626H|HBS1L_ENST00000527578.1_Missense_Mutation_p.R504H	NM_001145158.1|NM_006620.3	NP_001138630.1|NP_006611.1	Q9Y450	HBS1L_HUMAN	HBS1-like (S. cerevisiae)	668					signal transduction		GTP binding|GTPase activity|translation elongation factor activity	p.R668P(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	20	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0046)|GBM - Glioblastoma multiforme(68;0.00702)		ACCACCGTAACGTAGCATGAA	0.378000													41	34					0	0	1	0	0
TGM1	7051	broad.mit.edu	37	14	24723923	24723923	+	Missense_Mutation	SNP	C	C	T			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr14:24723923C>T	ENST00000206765.6	-	13	2158	c.2035G>A	c.(2035-2037)Gtg>Atg	p.V679M	TGM1_ENST00000544573.1_Missense_Mutation_p.V237M	NM_000359.2	NP_000350.1	P22735	TGM1_HUMAN	transglutaminase 1	679					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)	24				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	TTGGCCAGCACCTGCCCGCTC	0.617000													17	42					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114123222	114123222	+	Silent	SNP	C	C	T	rs141978579	byFrequency	TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr1:114123222C>T	ENST00000369615.1	+	3	554	c.492C>T	c.(490-492)tcC>tcT	p.S164S	MAGI3_ENST00000307546.9_Silent_p.S164S|MAGI3_ENST00000486456.1_3'UTR|MAGI3_ENST00000369617.4_Silent_p.S164S|MAGI3_ENST00000369611.4_Silent_p.S164S	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	164	Guanylate kinase-like.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATTTCATTTCCGTTGAACAGT	0.393000													9	72					0	0	1	0	0
GNAQ	2776	broad.mit.edu	37	9	80409488	80409488	+	Missense_Mutation	SNP	T	T	G	rs121913492		TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr9:80409488T>G	ENST00000286548.4	-	5	848	c.626A>C	c.(625-627)cAa>cCa	p.Q209P	GNAQ_ENST00000397476.3_Missense_Mutation_p.Q7P	NM_002072.3	NP_002063.2	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein), q polypeptide	209					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity	p.Q209L(87)|p.Q209P(64)|p.Q209Y(1)|p.Q209R(1)		NS(1)|endometrium(3)|eye(229)|kidney(1)|large_intestine(4)|lung(6)|meninges(11)|ovary(1)|prostate(1)|skin(44)|upper_aerodigestive_tract(1)	302						CTCTGACCTTTGGCCCCCTAC	0.348000			Mis		uveal melanoma								17	20					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134146968	134146968	+	Missense_Mutation	SNP	C	C	T			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr8:134146968C>T	ENST00000220616.4	+	48	8277	c.8237C>T	c.(8236-8238)aCg>aTg	p.T2746M	TG_ENST00000377869.1_Missense_Mutation_p.T2689M|TG_ENST00000519543.1_Missense_Mutation_p.T879M|TG_ENST00000542445.1_Missense_Mutation_p.T1116M	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2746					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GAGGAGTTGACGGCTGGATCT	0.547000													9	20					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108384832	108384832	+	Nonsense_Mutation	SNP	G	G	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr11:108384832G>A	ENST00000265843.4	-	6	1512	c.1402C>T	c.(1402-1404)Cga>Tga	p.R468*	EXPH5_ENST00000525344.1_Nonsense_Mutation_p.R461*|EXPH5_ENST00000524840.1_5'UTR|EXPH5_ENST00000428840.1_Nonsense_Mutation_p.R392*|EXPH5_ENST00000443411.1_Nonsense_Mutation_p.R280*	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	468					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TCTCCGCTTCGTCCAAAGGTA	0.438000													45	62					0	0	1	0	0
AFTPH	54812	broad.mit.edu	37	2	64778732	64778732	+	Missense_Mutation	SNP	G	G	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr2:64778732G>A	ENST00000422803.1	+	2	438	c.124G>A	c.(124-126)Gta>Ata	p.V42I	AFTPH_ENST00000409933.1_Missense_Mutation_p.V42I|AFTPH_ENST00000238856.4_Missense_Mutation_p.V42I|AFTPH_ENST00000238855.7_Missense_Mutation_p.V42I			Q6ULP2	AFTIN_HUMAN	aftiphilin	42					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						CCCTTCTGGTGTAGGGTTTGT	0.408000													5	116					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977342	29977342	+	RNA	SNP	A	A	T	rs116382006	by1000genomes	TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr6:29977342A>T	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA																							TGGGACTGAGAGGCAAGATTT	0.438000													4	61					0	0	1	0	0
AMELX	265	broad.mit.edu	37	X	11316686	11316686	+	Missense_Mutation	SNP	G	G	C			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chrX:11316686G>C	ENST00000380712.3	+	6	273	c.205G>C	c.(205-207)Gag>Cag	p.E69Q	ARHGAP6_ENST00000380718.1_Intron|ARHGAP6_ENST00000380732.3_Intron|ARHGAP6_ENST00000337414.4_Intron|AMELX_ENST00000380714.3_Missense_Mutation_p.E55Q|ARHGAP6_ENST00000413512.3_Intron|AMELX_ENST00000348912.4_Missense_Mutation_p.E39Q|ARHGAP6_ENST00000380736.1_Intron	NM_182680.1	NP_872621.1	Q99217	AMELX_HUMAN	amelogenin, X-linked	55					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel			endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	15						CTATGGTTACGAGCCCATGGG	0.547000													56	53					0	0	1	0	0
OR9I1	219954	broad.mit.edu	37	11	57886445	57886445	+	Silent	SNP	G	G	A			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr11:57886445G>A	ENST00000302610.1	-	1	471	c.472C>T	c.(472-474)Ctg>Ttg	p.L158L	OR9Q1_ENST00000335397.3_Intron	NM_001005211.1	NP_001005211.1	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I, member 1	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|liver(1)|lung(15)|pancreas(1)|skin(1)|urinary_tract(1)	23		Breast(21;0.0589)				GTGGTACGCAGGATGGCTCCT	0.547000													15	20					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14284600	14284600	+	RNA	DEL	A	A	-	rs79477301		TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr11:14284600delA	ENST00000310358.7	+	0	2795				RP11-21L19.1_ENST00000534587.1_RNA			Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GGACCTGTTTaaaaaaaaaaa	0.463													5	8	---	---	---	---					
PEAK1	79834	broad.mit.edu	37	15	77472300	77472300	+	Frame_Shift_Del	DEL	T	T	-			TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr15:77472300delT	ENST00000560626.2	-	4	2444	c.1969delA	c.(1969-1971)ccfs	p.T658fs	PEAK1_ENST00000312493.4_Frame_Shift_Del_p.T658fs|PEAK1_ENST00000558305.1_Frame_Shift_Del_p.T658fs			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	658					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										ACACTTGTGGTTTTTTCCTTC	0.363													31	72	---	---	---	---					
LOC101927755	101927755	broad.mit.edu	37	17	58050841	58050841	+	RNA	DEL	T	T	-	rs74362551		TCGA-RP-A690-06A-11D-A30X-08	TCGA-RP-A690-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd4bd518-af5a-4a40-beaa-42f91cdf8e90	c215c258-85e4-4673-963d-7e296b5f2ac9	g.chr17:58050841delT	ENST00000586209.1	+	0	158																											acagggtttcTTTTTTTTTTT	0.413													5	10	---	---	---	---