Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
MTF2	22823	broad.mit.edu	37	1	93594899	93594899	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr1:93594899C>T	uc009wdj.2	+	11	1346	c.1054C>T	c.(1054-1056)CCT>TCT	p.P352S	MTF2_uc010oth.1_Missense_Mutation_p.P250S|MTF2_uc009wdk.2_Intron|MTF2_uc001dpi.3_Missense_Mutation_p.P79S|MTF2_uc010oti.1_Missense_Mutation_p.P250S|MTF2_uc001dpj.3_Missense_Mutation_p.P250S|MTF2_uc001dpl.3_Missense_Mutation_p.P250S|MTF2_uc001dpm.3_Missense_Mutation_p.P21S	NM_007358	NP_031384	Q9Y483	MTF2_HUMAN	metal response element binding transcription	352						nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)		TCGTGTTCCTCCTGTGCCACC	0.323000												
WNT2B	7482	broad.mit.edu	37	1	113058764	113058764	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr1:113058764A>G	uc001ecb.2	+	3	921	c.406A>G	c.(406-408)AGC>GGC	p.S136G	WNT2B_uc001eca.2_Missense_Mutation_p.S117G|WNT2B_uc009wgg.2_Missense_Mutation_p.S44G	NM_024494	NP_078613	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family,	136					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			ovary(2)|breast(2)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTCTCTAGGTAGCCGAGAGGC	0.517000												
PTGFRN	5738	broad.mit.edu	37	1	117491914	117491914	+	Silent	SNP	C	C	T	rs140719535		TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr1:117491914C>T	uc001egv.1	+	4	1070	c.933C>T	c.(931-933)CCC>CCT	p.P311P		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	311	Ig-like C2-type 3.|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		ACGTCCGGCCCGAGGTGACGT	0.607000												
PIAS3	10401	broad.mit.edu	37	1	145584516	145584516	+	Silent	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr1:145584516C>T	uc001eoc.1	+	12	1574	c.1483C>T	c.(1483-1485)CTA>TTA	p.L495L	NBPF10_uc001emp.3_Intron|PIAS3_uc001eod.1_Silent_p.L164L	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	495					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATCCTCGGTGCTAAGGAGCCC	0.607000												
OTUD7B	56957	broad.mit.edu	37	1	149921651	149921651	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr1:149921651T>C	uc001etn.2	-	9	1360	c.1004A>G	c.(1003-1005)TAT>TGT	p.Y335C		NM_020205	NP_064590	Q6GQQ9	OTU7B_HUMAN	zinc finger protein Cezanne	335	Catalytic.|OTU.|TRAF-binding.				negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			CAAAGGCAGATAGATTCCTCC	0.532000												
ZNF248	57209	broad.mit.edu	37	10	38121178	38121178	+	Missense_Mutation	SNP	G	G	T	rs137877519		TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr10:38121178G>T	uc001izd.1	-	6	1604	c.1105C>A	c.(1105-1107)CAG>AAG	p.Q369K	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Missense_Mutation_p.Q369K	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTCCGAAGCTGGGTAAGATGT	0.408000												
GRID1	2894	broad.mit.edu	37	10	87407072	87407072	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr10:87407072T>C	uc001kdl.1	-	13	2181	c.2080A>G	c.(2080-2082)AAG>GAG	p.K694E	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.K265E|uc001kdm.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	694	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TTGGTGCCCTTGGCTCGGAAG	0.537000										Multiple Myeloma(13;0.14)		
LOXL4	84171	broad.mit.edu	37	10	100015439	100015439	+	Missense_Mutation	SNP	G	G	A	rs149982668		TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr10:100015439G>A	uc001kpa.1	-	10	1637	c.1486C>T	c.(1486-1488)CGC>TGC	p.R496C		NM_032211	NP_115587	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4 precursor	496	SRCR 4.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			ovary(3)|breast(1)|skin(1)	5		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		CCTGAGCAGCGCACCCCACTC	0.637000												
HPSE2	60495	broad.mit.edu	37	10	100481463	100481463	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr10:100481463C>A	uc001kpn.1	-	5	967	c.907G>T	c.(907-909)GGC>TGC	p.G303C	HPSE2_uc009xwc.1_Missense_Mutation_p.G293C|HPSE2_uc001kpo.1_Missense_Mutation_p.G235C|HPSE2_uc009xwd.1_Missense_Mutation_p.G181C	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	303					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		ATATTAGGGCCATATAAGCTG	0.468000												
CNNM2	54805	broad.mit.edu	37	10	104679833	104679833	+	Silent	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr10:104679833C>T	uc001kwm.2	+	1	1720	c.1596C>T	c.(1594-1596)GAC>GAT	p.D532D	CNNM2_uc001kwn.2_Silent_p.D532D|CNNM2_uc001kwl.2_Silent_p.D532D	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	532	CBS 2.				ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CCAAGTTGGACGCTATGCTGG	0.458000												
SLK	9748	broad.mit.edu	37	10	105750529	105750529	+	Silent	SNP	T	T	C			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr10:105750529T>C	uc001kxo.1	+	2	281	c.247T>C	c.(247-249)TTA>CTA	p.L83L	SLK_uc001kxp.1_Silent_p.L83L	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	83	Protein kinase.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GATTGACATATTAGCATCTTG	0.368000												
BTBD16	118663	broad.mit.edu	37	10	124089067	124089067	+	Silent	SNP	T	T	C			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr10:124089067T>C	uc001lgc.1	+	11	1235	c.984T>C	c.(982-984)CGT>CGC	p.R328R	BTBD16_uc001lgd.1_Silent_p.R327R	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	328										skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				TCTGCTTGCGTCTGCACGGCA	0.602000												
PPP2R2D	55844	broad.mit.edu	37	10	133761176	133761176	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr10:133761176G>A	uc001lks.2	+	6	1107	c.864G>A	c.(862-864)ATG>ATA	p.M288I	PPP2R2D_uc001lkr.2_Missense_Mutation_p.M94I|PPP2R2D_uc001lkt.2_Missense_Mutation_p.M94I|PPP2R2D_uc009yay.2_Missense_Mutation_p.M156I	NM_018461	NP_060931	Q66LE6	2ABD_HUMAN	protein phosphatase 2, regulatory subunit B,	321	WD 5.			M -> T (in Ref. 1; BAF85754).	cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			skin(1)	1		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)		ACCTCAACATGGAGAGCAGGC	0.498000												
MYOD1	4654	broad.mit.edu	37	11	17741344	17741344	+	Silent	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr11:17741344G>A	uc001mni.2	+	1	235	c.15G>A	c.(13-15)TCG>TCA	p.S5S		NM_002478	NP_002469	P15172	MYOD1_HUMAN	myogenic differentiation 1	5					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity			breast(2)|ovary(1)	3						AGCTACTGTCGCCACCGCTCC	0.667000												
CD44	960	broad.mit.edu	37	11	35243229	35243229	+	Silent	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr11:35243229G>A	uc001mvu.2	+	17	2408	c.1974G>A	c.(1972-1974)TTG>TTA	p.L658L	CD44_uc001mvv.2_Silent_p.L615L|CD44_uc001mvw.2_Silent_p.L409L|CD44_uc001mvx.2_Silent_p.L277L|CD44_uc001mvy.2_Intron|CD44_uc001mwc.3_Silent_p.L345L|CD44_uc010rer.1_Silent_p.L256L|CD44_uc009ykh.2_RNA	NM_000610	NP_000601	P16070	CD44_HUMAN	CD44 antigen isoform 1 precursor	658	Helical; (Potential).				cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			pancreas(1)	1	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	CATCCCTCTTGGCCTTGGCTT	0.428000												
C2CD3	26005	broad.mit.edu	37	11	73789208	73789208	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr11:73789208C>T	uc001ouu.2	-	23	4782	c.4555G>A	c.(4555-4557)GAC>AAC	p.D1519N	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1519						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					CTGGCCAGGTCCACATAGGCT	0.493000												
CACNA1C	775	broad.mit.edu	37	12	2706664	2706664	+	Splice_Site	SNP	T	T	C			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr12:2706664T>C	uc009zdu.1	+	22	3226	c.2913_splice	c.e22+2	p.K971_splice	CACNA1C_uc009zdv.1_Intron|CACNA1C_uc001qkb.2_Splice_Site_p.K951_splice|CACNA1C_uc001qkc.2_Splice_Site_p.K951_splice|CACNA1C_uc001qke.2_Splice_Site_p.K951_splice|CACNA1C_uc001qkf.2_Splice_Site_p.K951_splice|CACNA1C_uc001qjz.2_Intron|CACNA1C_uc001qkd.2_Intron|CACNA1C_uc001qkg.2_Intron|CACNA1C_uc009zdw.1_Intron|CACNA1C_uc001qkh.2_Intron|CACNA1C_uc001qkl.2_Splice_Site_p.K971_splice|CACNA1C_uc001qkn.2_Splice_Site_p.K951_splice|CACNA1C_uc001qko.2_Splice_Site_p.K971_splice|CACNA1C_uc001qkp.2_Splice_Site_p.K951_splice|CACNA1C_uc001qkr.2_Splice_Site_p.K951_splice|CACNA1C_uc001qku.2_Splice_Site_p.K951_splice|CACNA1C_uc001qkq.2_Intron|CACNA1C_uc001qks.2_Intron|CACNA1C_uc001qkt.2_Intron|CACNA1C_uc001qka.1_Splice_Site_p.K486_splice|CACNA1C_uc001qki.1_Intron|CACNA1C_uc001qkj.1_Intron|CACNA1C_uc001qkk.1_Intron|CACNA1C_uc001qkm.1_Intron	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,						axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ATCCTTAAGGTAATGCAACCT	0.388000												
VWF	7450	broad.mit.edu	37	12	6122735	6122735	+	Silent	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr12:6122735G>A	uc001qnn.1	-	32	5782	c.5532C>T	c.(5530-5532)GGC>GGT	p.G1844G	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1844	VWFA 3; main binding site for collagens type I and III.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CGTTGGAGTCGCCTGCTGGGC	0.522000												
SCFD1	23256	broad.mit.edu	37	14	31191756	31191756	+	Silent	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr14:31191756C>T	uc001wqm.1	+	23	1851	c.1827C>T	c.(1825-1827)GAC>GAT	p.D609D	SCFD1_uc001wqn.1_Silent_p.D542D|SCFD1_uc010tpg.1_Silent_p.D550D|SCFD1_uc010tph.1_Silent_p.D424D|SCFD1_uc010amf.1_Silent_p.D424D|SCFD1_uc010tpi.1_Silent_p.D517D|SCFD1_uc010ame.1_Missense_Mutation_p.T531I	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	609					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		ATCTTGTTGACTACATAAAGG	0.328000												
C15orf55	256646	broad.mit.edu	37	15	34647250	34647250	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr15:34647250T>G	uc001zif.2	+	6	1462	c.1307T>G	c.(1306-1308)CTG>CGG	p.L436R	C15orf55_uc010ucc.1_Missense_Mutation_p.L464R|C15orf55_uc010ucd.1_Missense_Mutation_p.L454R	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	436						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CCTCAATTTCTGGCAGATCTG	0.478000			T	BRD3|BRD4	lethal midline carcinoma							
ADAMTSL3	57188	broad.mit.edu	37	15	84566718	84566718	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr15:84566718G>T	uc002bjz.3	+	14	1800	c.1576G>T	c.(1576-1578)GAA>TAA	p.E526*	ADAMTSL3_uc010bmt.1_Nonsense_Mutation_p.E526*|ADAMTSL3_uc010bmu.1_Nonsense_Mutation_p.E526*	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	526	TSP type-1 3.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			ACACATCAAAGAAGAATGTGT	0.453000												
SALL1	6299	broad.mit.edu	37	16	51175484	51175484	+	Missense_Mutation	SNP	C	C	T	rs140165636		TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr16:51175484C>T	uc010vgs.1	-	2	680	c.649G>A	c.(649-651)GGC>AGC	p.G217S	SALL1_uc010vgr.1_Missense_Mutation_p.G120S|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	217					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GAGGCCCCGCCGCACCTCGCT	0.592000												
SF3B3	23450	broad.mit.edu	37	16	70602310	70602310	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr16:70602310A>T	uc002ezf.2	+	22	3288	c.3077A>T	c.(3076-3078)GAT>GTT	p.D1026V		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	1026					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				ATCTTTGCTGATGATACCTAC	0.468000												
TM4SF5	9032	broad.mit.edu	37	17	4675218	4675218	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr17:4675218A>T	uc002fyw.1	+	1	32	c.1A>T	c.(1-3)ATG>TTG	p.M1L		NM_003963	NP_003954	O14894	T4S5_HUMAN	transmembrane 4 superfamily member 5	1	Cytoplasmic (Potential).					integral to plasma membrane				ovary(1)	1						ACACCTCACCATGTGTACGGG	0.567000												
TP53	7157	broad.mit.edu	37	17	7578208	7578208	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr17:7578208T>C	uc002gim.2	-	6	835	c.641A>G	c.(640-642)CAT>CGT	p.H214R	TP53_uc002gig.1_Missense_Mutation_p.H214R|TP53_uc002gih.2_Missense_Mutation_p.H214R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H82R|TP53_uc010cng.1_Missense_Mutation_p.H82R|TP53_uc002gii.1_Missense_Mutation_p.H82R|TP53_uc010cnh.1_Missense_Mutation_p.H214R|TP53_uc010cni.1_Missense_Mutation_p.H214R|TP53_uc002gij.2_Missense_Mutation_p.H214R|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H121R|TP53_uc002gio.2_Missense_Mutation_p.H82R|TP53_uc010vug.1_Missense_Mutation_p.H175R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	214	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> Y (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H214R(45)|p.0?(7)|p.H214Y(4)|p.H214Q(4)|p.H214D(3)|p.H214fs*5(2)|p.H214fs*33(2)|p.D208fs*1(1)|p.K164_P219del(1)|p.H214H(1)|p.H214fs*7(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213fs*32(1)|p.T211_S215delTFRHS(1)|p.H214_S215insX(1)|p.R209fs*6(1)|p.D208_V216delDRNTFRHSV(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACCACACTATGTCGAAAAGT	0.542000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
UBTF	7343	broad.mit.edu	37	17	42290195	42290195	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr17:42290195G>A	uc002igb.2	-	6	719	c.652C>T	c.(652-654)CGG>TGG	p.R218W	UBTF_uc002igc.2_Missense_Mutation_p.R218W|UBTF_uc010czs.2_Missense_Mutation_p.R218W|UBTF_uc002igd.2_Missense_Mutation_p.R218W|UBTF_uc010czt.2_Missense_Mutation_p.R218W|UBTF_uc002ige.2_Missense_Mutation_p.R218W	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	218	HMG box 2.				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		ACATCTGGCCGCACTTTGAGA	0.637000												
SIGLEC7	27036	broad.mit.edu	37	19	51645712	51645712	+	Missense_Mutation	SNP	C	C	T	rs140841032		TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr19:51645712C>T	uc002pvv.1	+	1	155	c.86C>T	c.(85-87)ACG>ATG	p.T29M	SIGLEC7_uc002pvw.1_Missense_Mutation_p.T29M|SIGLEC7_uc010eoq.1_RNA|SIGLEC7_uc010eor.1_Missense_Mutation_p.T29M	NM_014385	NP_055200	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7 isoform 1	29	Extracellular (Potential).				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			large_intestine(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		TACTCGCTGACGATGCAGAGT	0.493000												
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48848413	48848413	+	Silent	SNP	A	A	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr2:48848413A>T	uc010yol.1	+	4	2390	c.2343A>T	c.(2341-2343)ACA>ACT	p.T781T	STON1-GTF2A1L_uc002rwp.1_Silent_p.T781T|GTF2A1L_uc002rws.1_Silent_p.T77T|GTF2A1L_uc010yom.1_Silent_p.T43T|GTF2A1L_uc002rwt.2_Silent_p.T77T	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	781					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TGCACCAAACATTGCAATCGT	0.388000												
TSGA10	80705	broad.mit.edu	37	2	99725896	99725896	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr2:99725896G>A	uc002szg.3	-	4	635	c.7C>T	c.(7-9)CGA>TGA	p.R3*	TSGA10_uc002szh.3_Nonsense_Mutation_p.R3*|TSGA10_uc002szi.3_Nonsense_Mutation_p.R3*|TSGA10_uc010fin.1_Nonsense_Mutation_p.R3*|TSGA10_uc010yvn.1_Nonsense_Mutation_p.R3*	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	3					spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						GACCTACTTCGCATCATCTTT	0.393000												
IL18RAP	8807	broad.mit.edu	37	2	103059744	103059744	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr2:103059744C>A	uc002tbx.2	+	8	1365	c.881C>A	c.(880-882)TCT>TAT	p.S294Y	IL18RAP_uc010fiz.2_Missense_Mutation_p.S152Y	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	294	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						ATCAAAGATTCTGACCTAGAG	0.403000												
POTEE	445582	broad.mit.edu	37	2	131976213	131976213	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr2:131976213G>A	uc002tsn.2	+	1	290	c.238G>A	c.(238-240)GTG>ATG	p.V80M	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Translation_Start_Site|POTEE_uc002tsl.2_Translation_Start_Site	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	80							ATP binding				0						CAAGAGCAACGTGGGCGCTTC	0.602000												
LRP1B	53353	broad.mit.edu	37	2	141707814	141707814	+	Silent	SNP	A	A	G			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr2:141707814A>G	uc002tvj.1	-	20	4098	c.3126T>C	c.(3124-3126)TGT>TGC	p.C1042C	LRP1B_uc010fnl.1_Silent_p.C224C	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1042	Extracellular (Potential).|LDL-receptor class A 7.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTTCTTTAGTACAATTGATCT	0.363000										TSP Lung(27;0.18)		
SCN9A	6335	broad.mit.edu	37	2	167133781	167133781	+	Silent	SNP	T	T	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr2:167133781T>A	uc010fpl.2	-	16	2894	c.2553A>T	c.(2551-2553)TCA>TCT	p.S851S	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	862	II.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	GAGCCCCTACTGAGTTACCAA	0.413000												
ITGA4	3676	broad.mit.edu	37	2	182360534	182360534	+	Silent	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr2:182360534C>T	uc002unu.2	+	14	2173	c.1410C>T	c.(1408-1410)GAC>GAT	p.D470D	ITGA4_uc010frj.1_5'Flank	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	470	FG-GAP 7.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TAATTGTTGACGCTTCTTTAA	0.358000												
PMS1	5378	broad.mit.edu	37	2	190660534	190660534	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr2:190660534G>A	uc002urh.3	+	3	701	c.172G>A	c.(172-174)GGG>AGG	p.G58R	PMS1_uc010zga.1_Missense_Mutation_p.G58R|PMS1_uc010zgb.1_Intron|PMS1_uc002urk.3_Missense_Mutation_p.G58R|PMS1_uc002uri.3_Missense_Mutation_p.G58R|PMS1_uc010zgc.1_5'UTR|PMS1_uc010zgd.1_Intron|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Missense_Mutation_p.G58R|PMS1_uc010frz.2_Missense_Mutation_p.G58R|PMS1_uc010zfz.1_Missense_Mutation_p.G58R	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	58					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			GCGAGATAACGGGGAGGGTAT	0.328000			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR				
PYGB	5834	broad.mit.edu	37	20	25252030	25252030	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr20:25252030G>A	uc002wup.2	+	4	545	c.436G>A	c.(436-438)GAC>AAC	p.D146N		NM_002862	NP_002853	P11216	PYGB_HUMAN	brain glycogen phosphorylase	146					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					Pyridoxal Phosphate(DB00114)	GTGTTTCCTTGACTCAATGGC	0.502000												
L3MBTL	26013	broad.mit.edu	37	20	42169439	42169439	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr20:42169439G>A	uc010zwh.1	+	21	2358	c.2312G>A	c.(2311-2313)CGC>CAC	p.R771H	L3MBTL_uc002xkl.2_Missense_Mutation_p.R703H|L3MBTL_uc002xkm.2_Missense_Mutation_p.R703H|L3MBTL_uc010ggl.2_Missense_Mutation_p.R708H|L3MBTL_uc002xkn.1_Missense_Mutation_p.R462H|L3MBTL_uc002xko.2_Missense_Mutation_p.R355H|L3MBTL_uc002xkp.2_Missense_Mutation_p.R91H|SGK2_uc002xkq.1_5'UTR	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	703	SAM.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GACCAAGCACGCCTCTTCAAA	0.562000												
ADARB1	104	broad.mit.edu	37	21	46596225	46596225	+	Silent	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr21:46596225C>T	uc002zgy.2	+	4	1044	c.609C>T	c.(607-609)AGC>AGT	p.S203S	ADARB1_uc002zgr.2_Silent_p.S203S|ADARB1_uc002zgs.2_RNA|ADARB1_uc002zgw.2_Silent_p.S203S|ADARB1_uc002zgv.2_RNA|ADARB1_uc002zgt.2_Silent_p.S203S|ADARB1_uc010gpx.2_Intron|ADARB1_uc002zgq.2_RNA|ADARB1_uc002zgu.2_RNA|ADARB1_uc011afo.1_Silent_p.S252S	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2	203					adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		TCAGTTCCAGCGGGGACCTCA	0.597000												
SBF1	6305	broad.mit.edu	37	22	50893258	50893258	+	Silent	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr22:50893258C>T	uc003blh.2	-	35	4992	c.4797G>A	c.(4795-4797)GCG>GCA	p.A1599A	SBF1_uc003ble.2_Silent_p.A75A|SBF1_uc003blf.2_Silent_p.A75A|SBF1_uc011arx.1_Silent_p.A1237A	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1573	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CGTCCTCGGGCGCATACATGT	0.652000												
CD96	10225	broad.mit.edu	37	3	111264125	111264125	+	Silent	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr3:111264125G>A	uc003dxw.2	+	2	464	c.294G>A	c.(292-294)GGG>GGA	p.G98G	CD96_uc003dxv.2_Silent_p.G98G|CD96_uc003dxx.2_Silent_p.G98G|CD96_uc010hpy.1_Silent_p.G98G	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor	98	Extracellular (Potential).|Ig-like V-type 1.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						CTGAGAATGGGTCAAAATGGA	0.448000									Opitz_Trigonocephaly_syndrome			
CCDC80	151887	broad.mit.edu	37	3	112356885	112356885	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr3:112356885C>T	uc003dzf.2	-	2	2086	c.1868G>A	c.(1867-1869)CGA>CAA	p.R623Q	CCDC80_uc011bhv.1_Missense_Mutation_p.R623Q|CCDC80_uc003dzg.2_Missense_Mutation_p.R623Q|CCDC80_uc003dzh.1_Missense_Mutation_p.R623Q	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	623										ovary(2)	2						AAGGAGTCTTCGTTTGCCTTC	0.463000												
PLS1	5357	broad.mit.edu	37	3	142416830	142416830	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr3:142416830A>G	uc010huv.2	+	12	1451	c.1292A>G	c.(1291-1293)TAT>TGT	p.Y431C	PLS1_uc003euz.2_Missense_Mutation_p.Y431C|PLS1_uc003eva.2_Missense_Mutation_p.Y431C	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1	431	CH 3.|Actin-binding 2.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1						TTTCAGCTCTATGAGATGATC	0.433000												
PIGZ	80235	broad.mit.edu	37	3	196675340	196675340	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr3:196675340G>A	uc003fxh.2	-	3	575	c.428C>T	c.(427-429)GCC>GTC	p.A143V		NM_025163	NP_079439	Q86VD9	PIGZ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	143	Helical; (Potential).				GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			ovary(3)	3	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		GTGGTACACGGCCCCGTCCAG	0.672000												
CSN1S1	1446	broad.mit.edu	37	4	70810618	70810618	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr4:70810618C>G	uc003hep.1	+	15	502	c.453C>G	c.(451-453)TAC>TAG	p.Y151*	CSN1S1_uc003heq.1_Nonsense_Mutation_p.Y142*|CSN1S1_uc003her.1_Nonsense_Mutation_p.Y143*	NM_001890	NP_001881	P47710	CASA1_HUMAN	casein alpha s1 isoform 1	151						extracellular region	protein binding|transporter activity				0						CTGTTTGGTACTATCCACAAA	0.413000												
TIGD2	166815	broad.mit.edu	37	4	90034294	90034294	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr4:90034294A>G	uc003hsk.2	+	1	327	c.169A>G	c.(169-171)AAC>GAC	p.N57D	FAM13A_uc003hsh.1_5'Flank	NM_145715	NP_663761	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	57					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		AAACTATGCAAACAGTTCAGA	0.373000												
UFSP2	55325	broad.mit.edu	37	4	186329110	186329110	+	Silent	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr4:186329110C>T	uc003ixo.2	-	9	1218	c.1101G>A	c.(1099-1101)ACG>ACA	p.T367T	UFSP2_uc003ixn.2_Silent_p.T242T|UFSP2_uc003ixq.2_Silent_p.T257T|UFSP2_uc003ixp.2_RNA	NM_018359	NP_060829	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	367						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		GGATTTTTGACGTTATACCGA	0.373000												
GPR98	84059	broad.mit.edu	37	5	90074406	90074406	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr5:90074406C>T	uc003kju.2	+	63	12925	c.12829C>T	c.(12829-12831)CGA>TGA	p.R4277*	GPR98_uc003kjt.2_Nonsense_Mutation_p.R1983*|GPR98_uc003kjw.2_5'Flank	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4277	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGAGCAACTTCGAGTGTCAGA	0.413000												
ETF1	2107	broad.mit.edu	37	5	137844018	137844018	+	Silent	SNP	T	T	C			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr5:137844018T>C	uc003ldc.3	-	11	1455	c.1290A>G	c.(1288-1290)GAA>GAG	p.E430E	ETF1_uc011cyv.1_Silent_p.E416E|ETF1_uc010jex.2_RNA|ETF1_uc003ldd.3_Silent_p.E397E	NM_004730	NP_004721	P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	430					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GGTCAAAAAATTCATCGTCTC	0.488000												
CDYL	9425	broad.mit.edu	37	6	4892004	4892004	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr6:4892004C>T	uc003mwi.2	+	4	375	c.244C>T	c.(244-246)CGG>TGG	p.R82W	CDYL_uc003mwj.2_Missense_Mutation_p.R28W|CDYL_uc003mwk.2_Intron|CDYL_uc011dhx.1_5'UTR|CDYL_uc011dhy.1_5'UTR	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	82	Chromo.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		GTATTTGGTTCGGTGGAAAGG	0.408000												
HIST1H2AD	3013	broad.mit.edu	37	6	26199399	26199399	+	Nonsense_Mutation	SNP	G	G	A	rs140533379		TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr6:26199399G>A	uc003ngw.2	-	1	73	c.73C>T	c.(73-75)CAG>TAG	p.Q25*	HIST1H3D_uc003ngv.2_5'UTR|HIST1H2BF_uc003ngx.2_5'Flank	NM_021065	NP_066409	P20671	H2A1D_HUMAN	histone cluster 1, H2ad	25					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.196)				ACAGGGAACTGGAGTCCGGCC	0.612000												
TRERF1	55809	broad.mit.edu	37	6	42236873	42236873	+	Silent	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr6:42236873G>A	uc003osd.2	-	5	1019	c.456C>T	c.(454-456)AAC>AAT	p.N152N	TRERF1_uc011duq.1_Silent_p.N152N|TRERF1_uc003osb.2_5'UTR|TRERF1_uc003osc.2_5'UTR|TRERF1_uc003ose.2_Silent_p.N152N	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	152					cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GCAGGTTTTGGTTGGCAAACA	0.557000												
TPBG	7162	broad.mit.edu	37	6	83075655	83075655	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr6:83075655C>T	uc003pjn.3	+	3	1913	c.977C>T	c.(976-978)CCG>CTG	p.P326L	TPBG_uc010kbj.2_Missense_Mutation_p.P326L|TPBG_uc003pjo.2_Missense_Mutation_p.P326L	NM_006670	NP_006661	Q13641	TPBG_HUMAN	trophoblast glycoprotein precursor	326	Extracellular (Potential).|LRRCT.				cell adhesion	integral to plasma membrane				central_nervous_system(1)	1		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		TGTGCATATCCGGAAAAAATG	0.537000												
NPY	4852	broad.mit.edu	37	7	24325011	24325011	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr7:24325011C>T	uc003sww.1	+	2	238	c.152C>T	c.(151-153)GCG>GTG	p.A51V		NM_000905	NP_000896	P01303	NPY_HUMAN	neuropeptide Y precursor	51					adult feeding behavior|calcium ion transport|cell proliferation|cellular component movement|central nervous system neuron development|cerebral cortex development|digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|neuron projection development|neuropeptide signaling pathway|positive regulation of appetite|synaptic transmission	cell|extracellular space	calcium channel regulator activity|G-protein coupled receptor activity|neuropeptide hormone activity				0						TACTACTCGGCGCTGCGACAC	0.632000												
BUD31	8896	broad.mit.edu	37	7	99015162	99015162	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr7:99015162G>C	uc003uqf.2	+	5	529	c.328G>C	c.(328-330)GAC>CAC	p.D110H	BUD31_uc011kiu.1_Missense_Mutation_p.D110H|BUD31_uc011kiv.1_Missense_Mutation_p.D110H|BUD31_uc003uqg.3_Missense_Mutation_p.D110H	NM_003910	NP_003901	P41223	BUD31_HUMAN	G10 protein	110					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_cancers(62;1.76e-08)|all_epithelial(64;1.63e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TCAGACACGGGACACCAACTT	0.453000												
RBM28	55131	broad.mit.edu	37	7	127978360	127978360	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr7:127978360T>C	uc003vmp.2	-	5	600	c.485A>G	c.(484-486)AAA>AGA	p.K162R	RBM28_uc003vmo.2_5'Flank|RBM28_uc011koj.1_Intron|RBM28_uc011kok.1_Missense_Mutation_p.K109R	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	162	RRM 2.				mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						TAGGAGGTTTTTGAACTGAAC	0.418000												
RBM33	155435	broad.mit.edu	37	7	155534608	155534608	+	Silent	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr7:155534608G>A	uc010lqk.1	+	13	2513	c.2145G>A	c.(2143-2145)CCG>CCA	p.P715P	RBM33_uc011kvv.1_Silent_p.P524P	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	715							nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		CCATAGCGCCGTCACACGTGA	0.562000												
NEIL2	252969	broad.mit.edu	37	8	11643642	11643642	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr8:11643642C>T	uc003wug.2	+	5	1534	c.859C>T	c.(859-861)CAG>TAG	p.Q287*	NEIL2_uc003wue.2_Nonsense_Mutation_p.Q287*|NEIL2_uc003wuf.2_Nonsense_Mutation_p.Q226*|NEIL2_uc011kxd.1_Nonsense_Mutation_p.Q171*	NM_145043	NP_659480	Q969S2	NEIL2_HUMAN	nei like 2 isoform a	287	FPG-type.				base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding				0	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		ACAGGTCTACCAGAAAGAACA	0.622000								BER_DNA_glycosylases				
FDFT1	2222	broad.mit.edu	37	8	11687890	11687890	+	Silent	SNP	C	C	G			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr8:11687890C>G	uc003wui.2	+	6	992	c.840C>G	c.(838-840)CTC>CTG	p.L280L	FDFT1_uc003wuh.2_Silent_p.L216L|FDFT1_uc010lsa.1_Silent_p.L195L|FDFT1_uc011kxe.1_Silent_p.L216L|FDFT1_uc011kxf.1_Silent_p.L237L|FDFT1_uc011kxg.1_Silent_p.L113L|FDFT1_uc003wuj.2_Silent_p.L273L|FDFT1_uc010lsb.2_Silent_p.L216L|FDFT1_uc011kxh.1_Silent_p.L216L|FDFT1_uc011kxi.1_Intron|FDFT1_uc011kxj.1_Silent_p.L216L|FDFT1_uc003wuk.2_Silent_p.L339L|FDFT1_uc011kxk.1_Silent_p.L195L	NM_004462	NP_004453	P37268	FDFT_HUMAN	squalene synthase	280					cholesterol biosynthetic process|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	farnesyl-diphosphate farnesyltransferase activity|oxidoreductase activity|protein binding|squalene synthase activity				0	all_epithelial(15;0.234)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.18)		TTTCGAGACTCAGAAACCAGA	0.512000												
BRF2	55290	broad.mit.edu	37	8	37702081	37702081	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr8:37702081G>A	uc003xkk.2	-	4	1297	c.1187C>T	c.(1186-1188)CCT>CTT	p.P396L		NM_018310	NP_060780	Q9HAW0	BRF2_HUMAN	RNA polymerase III transcription initiation	396					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding				0		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			AACTTCCTGAGGGGTACGCAA	0.527000												
ZNF704	619279	broad.mit.edu	37	8	81553643	81553643	+	Silent	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr8:81553643G>A	uc003yby.1	-	9	1429	c.1197C>T	c.(1195-1197)ACC>ACT	p.T399T		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	399						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			AGCGGCAGGCGGTACACCACA	0.612000												
DCAF13	25879	broad.mit.edu	37	8	104452417	104452417	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr8:104452417C>T	uc003yln.2	+	9	1737	c.1460C>T	c.(1459-1461)TCT>TTT	p.S487F	DCAF13_uc003ylm.1_Missense_Mutation_p.S220F|DCAF13_uc003ylo.2_Missense_Mutation_p.S198F	NM_015420	NP_056235	Q9NV06	DCA13_HUMAN	WD repeats and SOF1 domain containing	335	WD 7.				rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				breast(1)	1						AAATGGACTTCTGACAGCAAG	0.348000												
IFNB1	3456	broad.mit.edu	37	9	21077680	21077680	+	Silent	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr9:21077680C>T	uc003zok.2	-	1	264	c.189G>A	c.(187-189)GAG>GAA	p.E63E		NM_002176	NP_002167	P01574	IFNB_HUMAN	interferon, beta 1, fibroblast precursor	63					activation of caspase activity|B cell proliferation|blood coagulation|cellular response to exogenous dsRNA|defense response to virus|induction of apoptosis|natural killer cell activation|negative regulation of cell proliferation|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of viral genome replication|negative regulation of viral transcription|negative regulation of virion penetration into host cell|positive regulation of innate immune response|positive regulation of transcription from RNA polymerase II promoter|regulation of MHC class I biosynthetic process|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding|transcription corepressor activity			ovary(1)|breast(1)|kidney(1)	3				GBM - Glioblastoma multiforme(5;7.45e-142)|Lung(24;2.42e-17)|LUSC - Lung squamous cell carcinoma(38;7.17e-11)	Interferon beta-1a(DB00060)|Interferon beta-1b(DB00068)	GCTTAATCTCCTCAGGGATGT	0.453000												
TEK	7010	broad.mit.edu	37	9	27158095	27158095	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr9:27158095C>T	uc003zqi.3	+	2	761	c.319C>T	c.(319-321)CGA>TGA	p.R107*	TEK_uc010mjc.1_Intron|TEK_uc011lnn.1_Nonsense_Mutation_p.R107*|TEK_uc011lno.1_Nonsense_Mutation_p.R107*|TEK_uc011lnp.1_Intron|TEK_uc003zqj.1_Nonsense_Mutation_p.R84*	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	107	Extracellular (Potential).|Ig-like C2-type 1.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		AGGGCGAGTTCGAGGAGAGGC	0.463000												
DCAF12	25853	broad.mit.edu	37	9	34089583	34089583	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr9:34089583G>A	uc003ztt.2	-	8	1372	c.1030C>T	c.(1030-1032)CGG>TGG	p.R344W		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	344	WD 4.					centrosome|CUL4 RING ubiquitin ligase complex					0						CTCACTGACCGGATTCCTGAA	0.488000												
FCN1	2219	broad.mit.edu	37	9	137805455	137805455	+	Silent	SNP	G	G	A	rs144127766		TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr9:137805455G>A	uc004cfi.2	-	5	404	c.312C>T	c.(310-312)GAC>GAT	p.D104D		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	104					opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		ACTGCCCAGCGTCTCCTGTGT	0.592000												
MAGEC1	9947	broad.mit.edu	37	X	140996328	140996328	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chrX:140996328A>C	uc004fbt.2	+	4	3424	c.3138A>C	c.(3136-3138)AAA>AAC	p.K1046N	MAGEC1_uc010nsl.1_Missense_Mutation_p.K113N	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1046	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCACTAAAGTTTGGGTGC	0.552000										HNSCC(15;0.026)		
PLXNA3	55558	broad.mit.edu	37	X	153698807	153698807	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chrX:153698807A>C	uc004flm.2	+	30	5182	c.5009A>C	c.(5008-5010)GAT>GCT	p.D1670A		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1670	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AAGTTCGTGGATGACCTCTTT	0.607000												
PRRX1	5396	broad.mit.edu	37	1	170688997	170688997	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr1:170688996_170688996GA>G	uc001ghf.3	+	1	418	c.371_371GA>G	c.(370-372)cgafs	p.R124fs	PRRX1_uc001ghe.3_Frame_Shift_Del_p.R124fs	NM_022716	NP_073207	P54821	PRRX1_HUMAN	Homo sapiens paired related homeobox 1 (PRRX1), transcript variant pmx-1b, mRNA.	124						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity	p.R124L(2)		large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCTTTTGTGCGAGAAGACCTT	0.547												
NFKBIZ	64332	broad.mit.edu	37	3	101572358	101572358	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr3:101572357_101572357TC>T	uc003dvp.3	+	4	1102	c.987_987TC>T	c.(985-987)ggtfs	p.G329fs	NFKBIZ_uc003dvo.3_Frame_Shift_Del_p.G229fs|NFKBIZ_uc010hpo.3_Frame_Shift_Del_p.G229fs|NFKBIZ_uc003dvq.3_Intron	NM_031419	NP_001005474	Q9BYH8	IKBZ_HUMAN	Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (NFKBIZ), transcript variant 1, mRNA.	329	Required for transcriptional activity (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24						TCTTTGATGGTCCAGAATCAC	0.473												
DOK5	55816	broad.mit.edu	37	20	53171572	53171574	+	In_Frame_Del	DEL	ATC	ATC	-			TCGA-BR-4255-01A-01D-1126-08	TCGA-BR-4255-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c499388-9598-428d-a9b1-1808ce877345	f818c68d-6465-4ea9-a617-1e95a6b5ad0b	g.chr20:53171571_53171573TATC>T	uc002xwy.3	+	1	386_388	c.166_168TATC>T	c.(166-168)tat>T	p.Y56del		NM_018431	NP_060901	Q9P104	DOK5_HUMAN	Homo sapiens docking protein 5 (DOK5), mRNA.	56	PH.						insulin receptor binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|skin(1)	19			Colorectal(105;0.202)			TTTCAGGTGTTATCATAAGGTAA	0.374