Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
PDPN	10630	broad.mit.edu	37	1	13940872	13940872	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr1:13940872G>A	uc001avd.2	+	5	725	c.676G>A	c.(676-678)GTT>ATT	p.V226I	PDPN_uc001avc.2_Missense_Mutation_p.V226I|PDPN_uc009vob.2_Missense_Mutation_p.V108I|PDPN_uc009voc.2_Missense_Mutation_p.V108I|PDPN_uc001ave.2_Missense_Mutation_p.V108I|PDPN_uc001avf.2_Missense_Mutation_p.V108I	NM_006474	NP_006465	Q86YL7	PDPN_HUMAN	lung type-I cell membrane-associated	150	Helical; (Potential).				cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				ovary(2)	2	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		TGCAATCATCGTTGTGGTTAT	0.423000												
LEPRE1	64175	broad.mit.edu	37	1	43228097	43228097	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr1:43228097C>T	uc001chv.2	-	2	628	c.515G>A	c.(514-516)GGC>GAC	p.G172D	LEPRE1_uc001chw.2_Missense_Mutation_p.G172D|LEPRE1_uc001chx.3_Missense_Mutation_p.G172D|LEPRE1_uc001chy.3_Missense_Mutation_p.G172D	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	172	TPR 2.				negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CTCAGGATTGCCCACGAAGAA	0.468000												
BEST4	266675	broad.mit.edu	37	1	45250412	45250412	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr1:45250412G>A	uc001cmm.2	-	8	1086	c.1037C>T	c.(1036-1038)CCC>CTC	p.P346L		NM_153274	NP_695006	Q8NFU0	BEST4_HUMAN	bestrophin 4	346	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					CTTCTCAGCGGGGGGAAGGTT	0.637000												
USH2A	7399	broad.mit.edu	37	1	216348749	216348749	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr1:216348749T>A	uc001hku.1	-	21	4859	c.4472A>T	c.(4471-4473)GAA>GTA	p.E1491V	USH2A_uc001hkv.2_Missense_Mutation_p.E1491V	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1491	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTCAGTTCTTCAGGTGGAAA	0.438000										HNSCC(13;0.011)		
FAS	355	broad.mit.edu	37	10	90774152	90774152	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr10:90774152T>A	uc001kfr.2	+	9	1299	c.953T>A	c.(952-954)ATT>AAT	p.I318N	FAS_uc010qna.1_RNA|FAS_uc001kfs.2_3'UTR|FAS_uc001kft.2_Missense_Mutation_p.I297N|FAS_uc010qnb.1_RNA|FAS_uc010qnc.1_RNA|FAS_uc001kfw.2_3'UTR|FAS_uc010qnd.1_RNA|FAS_uc010qne.1_RNA|FAS_uc009xtp.2_RNA	NM_000043	NP_000034	P25445	TNR6_HUMAN	tumor necrosis factor receptor superfamily,	318	Cytoplasmic (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			upper_aerodigestive_tract(1)|breast(1)	2		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		CTCAAGGACATTACTAGTGAC	0.338000									Autoimmune_Lymphoproliferative_syndrome_type_I			
LRRK2	120892	broad.mit.edu	37	12	40740652	40740652	+	Silent	SNP	T	T	G			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr12:40740652T>G	uc001rmg.3	+	42	6328	c.6207T>G	c.(6205-6207)ACT>ACG	p.T2069T	LRRK2_uc009zjw.2_Silent_p.T907T|LRRK2_uc001rmi.2_Silent_p.T902T	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2069	Protein kinase.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTTTGACAACTGGAGGTAGAA	0.363000												
NEDD1	121441	broad.mit.edu	37	12	97345236	97345236	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr12:97345236A>T	uc001teu.3	+	15	2177	c.1838A>T	c.(1837-1839)AAT>ATT	p.N613I	NEDD1_uc001tev.3_Missense_Mutation_p.N613I|NEDD1_uc010svc.1_Missense_Mutation_p.N524I|NEDD1_uc001tew.2_Missense_Mutation_p.N620I|NEDD1_uc001tex.2_Missense_Mutation_p.N524I	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	613					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						GACATTGTGAATTTGCAAGTG	0.289000												
SLC5A8	160728	broad.mit.edu	37	12	101603454	101603454	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr12:101603454G>A	uc001thz.3	-	1	563	c.173C>T	c.(172-174)GCG>GTG	p.A58V		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	58	Helical; (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						GAGGGACAGCGCCACGGGCAC	0.632000												
CCDC60	160777	broad.mit.edu	37	12	119954427	119954427	+	Splice_Site	SNP	G	G	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr12:119954427G>T	uc001txe.2	+	8	1349	c.884_splice	c.e8-1	p.N295_splice	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60											ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		ATTCTCATCAGATCTGCAGAA	0.537000												
TMEM132B	114795	broad.mit.edu	37	12	126137113	126137113	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr12:126137113C>T	uc001uhe.1	+	8	2034	c.2026C>T	c.(2026-2028)CGA>TGA	p.R676*	TMEM132B_uc001uhf.1_Nonsense_Mutation_p.R188*	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	676	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GCAGCCACACCGAGCAGACAA	0.612000												
ANKRD10	55608	broad.mit.edu	37	13	111532325	111532325	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr13:111532325C>G	uc001vrn.2	-	6	1057	c.922G>C	c.(922-924)GGA>CGA	p.G308R	ANKRD10_uc001vrm.2_Missense_Mutation_p.G45R|ANKRD10_uc001vrl.2_RNA	NM_017664	NP_060134	Q9NXR5	ANR10_HUMAN	ankyrin repeat domain 10	308										central_nervous_system(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)			CTGCTAATTCCGTTAGTTCCT	0.532000												
OR4K17	390436	broad.mit.edu	37	14	20586246	20586246	+	Silent	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr14:20586246G>A	uc001vwo.1	+	1	681	c.681G>A	c.(679-681)CAG>CAA	p.Q227Q		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		ATTTTGTACAGGTAGTCATTG	0.413000												
BRMS1L	84312	broad.mit.edu	37	14	36302313	36302313	+	Splice_Site	SNP	T	T	C			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr14:36302313T>C	uc001wtl.2	+	3	487	c.361_splice	c.e3+2	p.G121_splice	BRMS1L_uc010tpx.1_Splice_Site_p.G73_splice	NM_032352	NP_115728	Q5PSV4	BRM1L_HUMAN	breast cancer metastasis-suppressor 1-like						regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				skin(1)	1	Breast(36;0.137)|Hepatocellular(127;0.158)		Lung(8;1.7e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.00467)|all cancers(34;0.0157)|BRCA - Breast invasive adenocarcinoma(188;0.158)	GBM - Glioblastoma multiforme(112;0.0333)		AGGTAGCAGGTAGGAAAGTGA	0.358000												
OCA2	4948	broad.mit.edu	37	15	28096604	28096604	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr15:28096604G>C	uc001zbh.3	-	22	2372	c.2262C>G	c.(2260-2262)AAC>AAG	p.N754K	OCA2_uc010ayv.2_Missense_Mutation_p.N730K	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	754	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CGTGGCTCAGGTTCAGGAGCA	0.582000									Oculocutaneous_Albinism			
DUOX2	50506	broad.mit.edu	37	15	45388106	45388106	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr15:45388106G>A	uc010bea.2	-	30	4203	c.4000C>T	c.(4000-4002)CGG>TGG	p.R1334W	DUOX2_uc001zun.2_Missense_Mutation_p.R1334W	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	1334	Cytoplasmic (Potential).|FAD-binding FR-type.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CCCACTGCCCGGATGTGCAGG	0.642000												
ADAMTSL3	57188	broad.mit.edu	37	15	84442350	84442350	+	Silent	SNP	C	C	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr15:84442350C>A	uc002bjz.3	+	4	489	c.265C>A	c.(265-267)CGG>AGG	p.R89R	ADAMTSL3_uc002bjy.1_Silent_p.R89R|ADAMTSL3_uc010bmt.1_Silent_p.R89R|ADAMTSL3_uc010bmu.1_Silent_p.R89R	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	89	TSP type-1 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGACTGCTCCCGGACCTGTGG	0.502000												
CDH1	999	broad.mit.edu	37	16	68842728	68842728	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr16:68842728A>G	uc002ewg.1	+	5	788	c.664A>G	c.(664-666)AGA>GGA	p.R222G	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.R222G	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	222	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GCCTCTGGATAGAGAACGCAT	0.478000			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer			
CDH1	999	broad.mit.edu	37	16	68856129	68856129	+	Splice_Site	SNP	G	G	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr16:68856129G>T	uc002ewg.1	+	12	2060	c.1936_splice	c.e12+1	p.T646_splice	CDH1_uc010vlj.1_Splice_Site|CDH1_uc010cfg.1_Splice_Site_p.T585_splice	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein						adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		AACGACCCAAGTGGGTACCTG	0.488000			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer			
ADAMTS18	170692	broad.mit.edu	37	16	77393318	77393318	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr16:77393318A>C	uc002ffc.3	-	8	1638	c.1219T>G	c.(1219-1221)TTT>GTT	p.F407V	ADAMTS18_uc010chc.1_5'UTR|ADAMTS18_uc002ffe.1_Missense_Mutation_p.F103V|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	407	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						ATGGGGGCAAACCCTATTGAA	0.433000												
IMP5	162540	broad.mit.edu	37	17	43923421	43923421	+	Silent	SNP	G	G	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr17:43923421G>T	uc010wka.1	+	1	1149	c.1149G>T	c.(1147-1149)CTG>CTT	p.L383L	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	383	Helical; (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		TGGCCCTGCTGGCCTTTGATG	0.582000												
TRIM25	7706	broad.mit.edu	37	17	54981760	54981760	+	Silent	SNP	C	C	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr17:54981760C>T	uc002iut.2	-	3	843	c.783G>A	c.(781-783)AGG>AGA	p.R261R	TRIM25_uc010dcj.2_Silent_p.R53R	NM_005082	NP_005073	Q14258	TRI25_HUMAN	tripartite motif-containing 25	261	Interaction with influenza A virus NS1.|Potential.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			lung(1)|breast(1)|skin(1)	3	Breast(9;6.15e-08)					CCTTTATCTTCCTTGTCGAGG	0.478000												
KCNH6	81033	broad.mit.edu	37	17	61611421	61611421	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr17:61611421G>A	uc002jay.2	+	5	930	c.850G>A	c.(850-852)GAT>AAT	p.D284N	KCNH6_uc002jax.1_Missense_Mutation_p.D284N|KCNH6_uc010wpl.1_Missense_Mutation_p.D161N|KCNH6_uc010wpm.1_Missense_Mutation_p.D284N|KCNH6_uc002jaz.1_Missense_Mutation_p.D284N	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	284	Extracellular (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CCTGCTCAGCGATCAGGACGA	0.592000												
SMAD4	4089	broad.mit.edu	37	18	48591918	48591918	+	Missense_Mutation	SNP	C	C	T	rs80338963		TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr18:48591918C>T	uc010xdp.1	+	9	1619	c.1081C>T	c.(1081-1083)CGC>TGC	p.R361C	SMAD4_uc002lfb.3_Missense_Mutation_p.R206C	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	361	MH2.		R -> H (in a colorectal cancer sample; somatic mutation).|R -> C (in JPS).		BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.R361C(6)|p.R361H(3)|p.?(2)|p.R361S(1)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		TGGAGGAGATCGCTTTTGTTT	0.413000									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia			
MUC16	94025	broad.mit.edu	37	19	9089753	9089753	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr19:9089753A>G	uc002mkp.2	-	1	2266	c.2062T>C	c.(2062-2064)TCA>CCA	p.S688P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	688	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGAAAGCTGAGGACTGTAGA	0.502000												
NAPSA	9476	broad.mit.edu	37	19	50864332	50864332	+	Silent	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr19:50864332G>A	uc002prx.2	-	5	587	c.534C>T	c.(532-534)TTC>TTT	p.F178F	NR1H2_uc002prv.3_Intron	NM_004851	NP_004842	O96009	NAPSA_HUMAN	napsin A preproprotein	178					proteolysis	extracellular region	aspartic-type endopeptidase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		GGGCAAAAGCGAAGACCAGGC	0.527000												
LILRA4	23547	broad.mit.edu	37	19	54848675	54848675	+	Silent	SNP	G	G	A	rs142322002	byFrequency	TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr19:54848675G>A	uc002qfj.2	-	5	1005	c.948C>T	c.(946-948)ATC>ATT	p.I316I	LILRA4_uc002qfi.2_Silent_p.I250I	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	316	Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CCTCACCTGCGATCAGGATGT	0.692000												
USP29	57663	broad.mit.edu	37	19	57641825	57641825	+	Silent	SNP	C	C	T	rs35663514		TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr19:57641825C>T	uc002qny.2	+	4	2138	c.1782C>T	c.(1780-1782)CCC>CCT	p.P594P		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	594					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGGTTCTACCCGTTGAACCAG	0.488000												
B3GNT7	93010	broad.mit.edu	37	2	232263406	232263406	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr2:232263406G>A	uc002vrs.2	+	2	1156	c.976G>A	c.(976-978)GAC>AAC	p.D326N		NM_145236	NP_660279	Q8NFL0	B3GN7_HUMAN	UDP-GlcNAc:betaGal	326	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;3.22e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		CTACCCGATCGACGACGTCTT	0.677000												
PRIC285	85441	broad.mit.edu	37	20	62196078	62196078	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr20:62196078C>T	uc002yfm.2	-	9	4989	c.4097G>A	c.(4096-4098)TGC>TAC	p.C1366Y	PRIC285_uc002yfl.1_Missense_Mutation_p.C797Y	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1366					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			AGCCACCTCGCACCTGGGACC	0.672000												
CDC45	8318	broad.mit.edu	37	22	19492984	19492984	+	Silent	SNP	A	A	G			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr22:19492984A>G	uc002zpr.2	+	10	880	c.804A>G	c.(802-804)ACA>ACG	p.T268T	CDC45_uc011agz.1_Silent_p.T263T|CDC45_uc011aha.1_Silent_p.T300T|CDC45_uc002zps.2_Silent_p.T268T|CDC45_uc002zpt.2_Silent_p.T222T	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	268					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1						TGGACTGCACACGGATCTCCT	0.572000												
COL7A1	1294	broad.mit.edu	37	3	48621022	48621022	+	Silent	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr3:48621022G>A	uc003ctz.2	-	40	4369	c.4368C>T	c.(4366-4368)GGC>GGT	p.G1456G		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1456	Triple-helical region.|Interrupted collagenous region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTCCTGGGAGGCCTGGAGCTC	0.627000												
SEMA5B	54437	broad.mit.edu	37	3	122680090	122680090	+	Silent	SNP	C	C	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr3:122680090C>T	uc003efz.1	-	2	325	c.21G>A	c.(19-21)CCG>CCA	p.P7P	SEMA5B_uc011bju.1_Intron|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.P7P|SEMA5B_uc010hro.1_Intron|SEMA5B_uc010hrp.1_Intron	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	7	Extracellular (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CAACAGGAGACGGACTGAAGC	0.577000												
ZBTB38	253461	broad.mit.edu	37	3	141161551	141161551	+	Silent	SNP	C	C	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr3:141161551C>T	uc003etw.2	+	8	1303	c.321C>T	c.(319-321)CTC>CTT	p.L107L	ZBTB38_uc010hun.2_Silent_p.L104L|ZBTB38_uc010huo.2_Silent_p.L107L|ZBTB38_uc003ety.2_Silent_p.L107L|ZBTB38_uc010hup.2_Silent_p.L108L	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	107					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TCACTGATCTCGCAGCTGCAG	0.423000												
DCHS2	54798	broad.mit.edu	37	4	155250824	155250824	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr4:155250824G>A	uc003inw.2	-	11	2404	c.2404C>T	c.(2404-2406)CGG>TGG	p.R802W	DCHS2_uc003inx.2_Missense_Mutation_p.R1257W	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	802	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGGTGCCCCCGGTGCTCACGA	0.552000												
RXFP1	59350	broad.mit.edu	37	4	159560437	159560437	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr4:159560437A>G	uc003ipz.2	+	14	1151	c.1069A>G	c.(1069-1071)AAT>GAT	p.N357D	RXFP1_uc010iqj.1_Missense_Mutation_p.N186D|RXFP1_uc011cja.1_Missense_Mutation_p.N252D|RXFP1_uc010iqo.2_Missense_Mutation_p.N309D|RXFP1_uc011cjb.1_Missense_Mutation_p.N255D|RXFP1_uc010iqk.2_Missense_Mutation_p.N225D|RXFP1_uc011cjc.1_Missense_Mutation_p.N276D|RXFP1_uc011cjd.1_Missense_Mutation_p.N276D|RXFP1_uc010iql.2_Missense_Mutation_p.N201D|RXFP1_uc011cje.1_Missense_Mutation_p.N384D|RXFP1_uc010iqm.2_Missense_Mutation_p.N324D|RXFP1_uc011cjf.1_Missense_Mutation_p.N226D|RXFP1_uc010iqn.2_Missense_Mutation_p.N302D	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	357	Extracellular (Potential).|LRR 9.					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		TGAAATTTCAAATATCCAACA	0.284000												
BDP1	55814	broad.mit.edu	37	5	70759924	70759924	+	Silent	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr5:70759924G>A	uc003kbp.1	+	4	902	c.639G>A	c.(637-639)TCG>TCA	p.S213S	BDP1_uc003kbn.1_Silent_p.S213S|BDP1_uc003kbo.2_Silent_p.S213S	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	213	Interaction with ZBTB43.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AAAAGCCATCGACTCCAGTCC	0.264000												
ACOT12	134526	broad.mit.edu	37	5	80631636	80631636	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr5:80631636G>A	uc003khl.3	-	12	1268	c.1213C>T	c.(1213-1215)CGT>TGT	p.R405C	RNU5E_uc011cto.1_Intron	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	405	START.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		GACAAGAGACGATAAGCCAAA	0.348000												
HSD17B4	3295	broad.mit.edu	37	5	118861675	118861675	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr5:118861675A>G	uc003ksj.2	+	19	1760	c.1637A>G	c.(1636-1638)CAG>CGG	p.Q546R	HSD17B4_uc011cwg.1_Missense_Mutation_p.Q522R|HSD17B4_uc011cwh.1_Missense_Mutation_p.Q528R|HSD17B4_uc011cwi.1_Missense_Mutation_p.Q571R|HSD17B4_uc003ksk.3_Missense_Mutation_p.Q399R|HSD17B4_uc011cwj.1_Missense_Mutation_p.Q399R|HSD17B4_uc010jcn.1_Missense_Mutation_p.Q284R|HSD17B4_uc010jco.1_Missense_Mutation_p.S15G	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	546	MaoC-like.|Enoyl-CoA hydratase 2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	CGTGTGTTACAGCAGTTTGCA	0.348000												
PCDHGA7	56108	broad.mit.edu	37	5	140764604	140764604	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr5:140764604C>T	uc003lka.1	+	1	2138	c.2138C>T	c.(2137-2139)GCG>GTG	p.A713V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGB4_uc003lkc.1_5'Flank|PCDHGA7_uc003ljz.1_Missense_Mutation_p.A713V|PCDHGB4_uc011dav.1_5'Flank	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	713	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTACTGCTGGCGCTCAGGCTG	0.632000												
HSPA1L	3305	broad.mit.edu	37	6	31779057	31779057	+	Silent	SNP	A	A	G			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr6:31779057A>G	uc003nxh.2	-	2	876	c.693T>C	c.(691-693)GGT>GGC	p.G231G	HSPA1L_uc010jte.2_Silent_p.G231G	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	231					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						AGTCCTCCCCACCCAGGTGAG	0.507000												
KIFC1	3833	broad.mit.edu	37	6	33372771	33372771	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr6:33372771T>G	uc003oef.3	+	7	1349	c.899T>G	c.(898-900)CTG>CGG	p.L300R	KIFC1_uc011drf.1_Missense_Mutation_p.L292R	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	300	Potential.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						CGCCGGCGACTGCACAACCAG	0.642000												
RIMS1	22999	broad.mit.edu	37	6	73102406	73102406	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr6:73102406A>G	uc003pga.2	+	31	4589	c.4512A>G	c.(4510-4512)ATA>ATG	p.I1504M	RIMS1_uc011dyb.1_Missense_Mutation_p.I901M|RIMS1_uc003pgc.2_Missense_Mutation_p.I953M|RIMS1_uc010kaq.2_Missense_Mutation_p.I824M|RIMS1_uc011dyc.1_Missense_Mutation_p.I629M|RIMS1_uc010kar.2_Missense_Mutation_p.I572M|RIMS1_uc011dyd.1_Missense_Mutation_p.I638M|RIMS1_uc003pgf.2_Missense_Mutation_p.I504M|RIMS1_uc003pgg.2_Missense_Mutation_p.I400M|RIMS1_uc003pgi.2_Missense_Mutation_p.I320M|RIMS1_uc003pgh.2_Missense_Mutation_p.I371M|RIMS1_uc003pgd.2_Missense_Mutation_p.I570M|RIMS1_uc003pge.2_Missense_Mutation_p.I544M|RIMS1_uc011dye.1_Missense_Mutation_p.I310M|RIMS1_uc011dyf.1_Missense_Mutation_p.I128M|RIMS1_uc011dyg.1_Missense_Mutation_p.I31M	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1504					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				ATAGTTTAATATTTCCTGGAG	0.418000												
SYNE1	23345	broad.mit.edu	37	6	152631075	152631075	+	Silent	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr6:152631075G>A	uc010kiw.2	-	90	17699	c.17097C>T	c.(17095-17097)CCC>CCT	p.P5699P	SYNE1_uc010kiv.2_Silent_p.P223P|SYNE1_uc003qos.3_Silent_p.P223P|SYNE1_uc003qot.3_Silent_p.P5628P|SYNE1_uc003qou.3_Silent_p.P5699P	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5699	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCACATCCTCGGGGATCCGGA	0.557000										HNSCC(10;0.0054)		
LPA	4018	broad.mit.edu	37	6	161015130	161015130	+	Silent	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr6:161015130G>A	uc003qtl.2	-	23	3609	c.3489C>T	c.(3487-3489)CCC>CCT	p.P1163P		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3671	Kringle 33.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CCTGGACCCCGGGGCTTTGCT	0.468000												
C8orf58	541565	broad.mit.edu	37	8	22458519	22458519	+	Silent	SNP	C	C	T	rs138371466		TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr8:22458519C>T	uc003xce.2	+	2	277	c.165C>T	c.(163-165)GTC>GTT	p.V55V	C8orf58_uc011kzl.1_Silent_p.V55V|C8orf58_uc003xcf.2_Silent_p.V55V	NM_001013842	NP_001013864	Q8NAV2	CH058_HUMAN	hypothetical protein LOC541565	55										skin(1)	1		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00563)|Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		TCAGAGGTGTCGGCAGGGAGG	0.637000												
ENTPD4	9583	broad.mit.edu	37	8	23305223	23305223	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr8:23305223G>A	uc003xdl.2	-	4	546	c.382C>T	c.(382-384)CGA>TGA	p.R128*	ENTPD4_uc011kzu.1_Nonsense_Mutation_p.R128*|ENTPD4_uc003xdm.2_Nonsense_Mutation_p.R128*|ENTPD4_uc011kzv.1_Nonsense_Mutation_p.R128*|ENTPD4_uc011kzw.1_Nonsense_Mutation_p.R94*	NM_004901	NP_004892	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	128	Lumenal (Potential).				UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		ACTGGCTTTCGGTTTTTATCC	0.453000												
KIF13B	23303	broad.mit.edu	37	8	28999695	28999695	+	Silent	SNP	T	T	C			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr8:28999695T>C	uc003xhh.3	-	19	2372	c.2313A>G	c.(2311-2313)AAA>AAG	p.K771K		NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	771	Potential.				microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		CTTCACACTCTTTCCACTCCT	0.403000												
AP3M2	10947	broad.mit.edu	37	8	42012282	42012282	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr8:42012282G>A	uc003xop.2	+	3	368	c.77G>A	c.(76-78)CGT>CAT	p.R26H	AP3M2_uc003xoo.2_Missense_Mutation_p.R26H|AP3M2_uc010lxe.2_RNA|AP3M2_uc003xoq.1_5'UTR|AP3M2_uc003xor.1_Missense_Mutation_p.R26H	NM_001134296	NP_001127768	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	26					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus					0	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			GTGGTCAGCCGTTCTGTTTGT	0.453000												
TOP1MT	116447	broad.mit.edu	37	8	144400005	144400005	+	Silent	SNP	C	C	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr8:144400005C>T	uc003yxz.2	-	10	1237	c.1218G>A	c.(1216-1218)ACG>ACA	p.T406T	TOP1MT_uc011lkd.1_Silent_p.T308T|TOP1MT_uc011lke.1_Silent_p.T308T|TOP1MT_uc010mfb.2_Silent_p.T308T|TOP1MT_uc011lkf.1_Silent_p.T201T	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	406					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	TCAGGCTGGTCGTCTGGGGAG	0.602000												
AK3	50808	broad.mit.edu	37	9	4712977	4712977	+	Nonstop_Mutation	SNP	C	C	G			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr9:4712977C>G	uc003ziq.1	-	5	823	c.683G>C	c.(682-684)TGA>TCA	p.*228S	AK3_uc003zip.1_RNA|AK3_uc011lma.1_Nonstop_Mutation_p.*188S|AK3_uc003zir.1_Nonstop_Mutation_p.*158S	NM_016282	NP_057366	Q9UIJ7	KAD3_HUMAN	adenylate kinase 3	228					blood coagulation	mitochondrial matrix	ATP binding|GTP binding|nucleoside triphosphate adenylate kinase activity			ovary(2)	2	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0302)		CATTTCTCCTCATGGAGTAAC	0.383000												
CER1	9350	broad.mit.edu	37	9	14720137	14720137	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr9:14720137A>G	uc003zlj.2	-	2	800	c.755T>C	c.(754-756)ATC>ACC	p.I252T		NM_005454	NP_005445	O95813	CER1_HUMAN	cerberus 1 precursor	252					BMP signaling pathway	extracellular space	cytokine activity				0				GBM - Glioblastoma multiforme(50;3.16e-06)		AGCATGTAGGATGTGTCCATC	0.488000												
SPTAN1	6709	broad.mit.edu	37	9	131339474	131339474	+	Silent	SNP	C	C	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr9:131339474C>T	uc004bvl.3	+	7	965	c.852C>T	c.(850-852)GGC>GGT	p.G284G	SPTAN1_uc011mbg.1_Silent_p.G284G|SPTAN1_uc011mbh.1_Silent_p.G296G|SPTAN1_uc004bvm.3_Silent_p.G284G|SPTAN1_uc004bvn.3_Silent_p.G284G	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	284	Spectrin 4.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ATGATTTTGGCCGAGACCTGG	0.483000												
L1CAM	3897	broad.mit.edu	37	X	153129907	153129907	+	Silent	SNP	C	C	T	rs142563956	byFrequency	TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chrX:153129907C>T	uc004fjb.2	-	24	3300	c.3192G>A	c.(3190-3192)TCG>TCA	p.S1064S	L1CAM_uc004fjc.2_Silent_p.S1064S|L1CAM_uc010nuo.2_Silent_p.S1059S	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	1064	Fibronectin type-III 5.|Extracellular (Potential).				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CATACTGTGGCGAAAGGGAAG	0.607000												
ASH1L	55870	broad.mit.edu	37	1	155451843	155451844	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr1:155451842_155451843C>CT	uc009wqq.3	-	2	1298_1299	c.818_819G>AG	c.(817-819)aagfs	p.K273fs	ASH1L_uc001fkt.3_Frame_Shift_Ins_p.K273fs|ASH1L_uc009wqr.1_Frame_Shift_Ins_p.K273fs	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	Homo sapiens ash1 (absent, small, or homeotic)-like (Drosophila) (ASH1L), mRNA.	273					DNA packaging|cell-cell signaling|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|chromosome|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TGATGGTTGGCTTTTTTATTAA	0.416												
INPPL1	3636	broad.mit.edu	37	11	71948209	71948209	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr11:71948208_71948208GC>G	uc001osf.3	+	25	3067	c.2920_2920GC>G	c.(2920-2922)gccfs	p.A974fs	INPPL1_uc001osg.3_Frame_Shift_Del_p.A732fs	NM_001567	NP_001558	O15357	SHIP2_HUMAN	Homo sapiens inositol polyphosphate phosphatase-like 1 (INPPL1), mRNA.	974	Pro-rich.				actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	SH2 domain binding|SH3 domain binding|actin binding	p.P977fs*7(1)		breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						AGGGGTGGCGGCCCCCCCACC	0.632												
MON2	23041	broad.mit.edu	37	12	62954432	62954433	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr12:62954431_62954432AGT>A	uc001sre.3	+	25	3961_3962	c.3570_3571AGT>A	c.(3568-3573)gtagttfs	p.V1190fs	MON2_uc010ssn.2_Frame_Shift_Del_p.V1190fs|MON2_uc009zqj.3_Frame_Shift_Del_p.V1190fs|MON2_uc010ssl.2_Frame_Shift_Del_p.V1118fs|MON2_uc010ssm.2_Frame_Shift_Del_p.V1167fs|MON2_uc001srf.3_Frame_Shift_Del_p.V953fs|MON2_uc001srg.3_Frame_Shift_Del_p.V65fs	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	Homo sapiens MON2 homolog (S. cerevisiae) (MON2), mRNA.	1191					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		CACCACCTGTAGTTAATGTACC	0.426												
BRWD1	54014	broad.mit.edu	37	21	40587280	40587280	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4279-01A-01D-1126-08	TCGA-BR-4279-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee907395-2e2f-471b-8840-f8b261a8c8f6	39c01fd0-41e5-402a-9060-6052f32ea50a	g.chr21:40587279_40587279AG>A	uc002yxk.2	-	31	3964	c.3669_3669CT>T	c.(3667-3669)tctfs	p.S1223fs	BRWD1_uc010goc.1_5'UTR|BRWD1_uc021wjf.1_Frame_Shift_Del_p.S1223fs|BRWD1_uc010god.1_Frame_Shift_Del_p.S189fs	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	Homo sapiens bromodomain and WD repeat domain containing 1 (BRWD1), transcript variant 1, mRNA.	1223	Bromo 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				AAACTAACGCAGACAGCCTCC	0.353