Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
RPL11	6135	broad.mit.edu	37	1	24018320	24018320	+	Splice_Site	SNP	G	G	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr1:24018320G>T	uc001bhk.2	+	1	26	c.6_splice	c.e1+1	p.A2_splice	RPL11_uc001bhl.2_Splice_Site_p.A2_splice|RPL11_uc001bhm.2_5'Flank|RPL11_uc001bhn.1_5'Flank	NM_000975	NP_000966	P62913	RL11_HUMAN	ribosomal protein L11						endocrine pancreas development|protein localization to nucleus|protein targeting|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.13e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		CATCATGGCGGTGAGTAGCTG	0.607000											OREG0013231	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
PAQR7	164091	broad.mit.edu	37	1	26189730	26189730	+	Silent	SNP	G	G	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr1:26189730G>A	uc001bkx.2	-	2	1268	c.601C>T	c.(601-603)CTG>TTG	p.L201L		NM_178422	NP_848509	Q86WK9	MPRA_HUMAN	progestin and adipoQ receptor family member VII	201	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			breast(3)	3		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.16e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000724)|BRCA - Breast invasive adenocarcinoma(304;0.000965)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0136)|READ - Rectum adenocarcinoma(331;0.0649)		GTGCGGCCCAGCAGGCCTGGT	0.592000												
WDR65	149465	broad.mit.edu	37	1	43647330	43647330	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr1:43647330C>T	uc001cip.1	+	3	404	c.283C>T	c.(283-285)CGG>TGG	p.R95W	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Missense_Mutation_p.R84W|WDR65_uc001ciq.1_Missense_Mutation_p.R95W	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65	95										skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CATCCCTTGCCGGAAGCGCAA	0.448000												
PTGFR	5737	broad.mit.edu	37	1	78958499	78958499	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr1:78958499C>T	uc001din.2	+	2	337	c.71C>T	c.(70-72)ACG>ATG	p.T24M	PTGFR_uc001dim.2_Missense_Mutation_p.T24M	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	24	Extracellular (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	ACCTGCCAGACGGAAAACCGG	0.448000												
RPL5	6125	broad.mit.edu	37	1	93301861	93301861	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr1:93301861G>C	uc001doz.2	+	5	517	c.439G>C	c.(439-441)GAT>CAT	p.D147H	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_RNA|RPL5_uc001dpb.2_Missense_Mutation_p.D97H|RPL5_uc001dpd.2_5'UTR|SNORD21_uc001dpe.2_5'Flank	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5	147					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		CTGCTATTTGGATGCAGGCCT	0.488000												
DDX21	9188	broad.mit.edu	37	10	70716038	70716038	+	Silent	SNP	A	A	G			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr10:70716038A>G	uc001jov.1	+	1	147	c.57A>G	c.(55-57)AAA>AAG	p.K19K	DDX21_uc001jow.1_5'Flank	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	19						nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						CAATGAAAAAAGGGGAGACAC	0.607000												
PRF1	5551	broad.mit.edu	37	10	72360571	72360571	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr10:72360571C>G	uc009xqg.2	-	2	249	c.88G>C	c.(88-90)GAG>CAG	p.E30Q	PRF1_uc001jrf.3_Missense_Mutation_p.E30Q	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	30	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						CGCTTGCACTCTGAGCGTGCG	0.687000			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis			
OR51G2	81282	broad.mit.edu	37	11	4936743	4936743	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr11:4936743G>C	uc001lzr.1	-	1	151	c.151C>G	c.(151-153)CTT>GTT	p.L51V		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	51	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGATAAAAAGAATTGTGCAG	0.512000												
DENND5A	23258	broad.mit.edu	37	11	9225374	9225374	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr11:9225374T>G	uc001mhl.2	-	4	1037	c.782A>C	c.(781-783)AAG>ACG	p.K261T	DENND5A_uc010rbw.1_Missense_Mutation_p.K261T|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	261	DENN.									liver(1)	1						CCCAGAAAACTTCAAGGACCG	0.532000												
OR4C15	81309	broad.mit.edu	37	11	55321938	55321938	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr11:55321938G>C	uc010rig.1	+	1	156	c.156G>C	c.(154-156)TTG>TTC	p.L52F		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	Error:Variant_position_missing_in_Q8NGM1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TCTTTTCCTTGGGAAACATGC	0.358000										HNSCC(20;0.049)		
SHANK2	22941	broad.mit.edu	37	11	70332306	70332306	+	Silent	SNP	G	G	C			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr11:70332306G>C	uc001oqc.2	-	21	4170	c.4092C>G	c.(4090-4092)GCC>GCG	p.A1364A	SHANK2_uc010rqn.1_Silent_p.A776A|SHANK2_uc001opz.2_Silent_p.A769A|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	985					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGGGCTCGGGGGCAGCGGAGA	0.622000												
PCF11	51585	broad.mit.edu	37	11	82868552	82868552	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr11:82868552C>G	uc001ozx.3	+	1	416	c.71C>G	c.(70-72)TCA>TGA	p.S24*	PCF11_uc010rsu.1_Nonsense_Mutation_p.S24*|PCF11_uc001ozy.2_Nonsense_Mutation_p.S24*	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	24	CID.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						GATTATCAGTCATCGCTCGAA	0.637000												
PCF11	51585	broad.mit.edu	37	11	82868584	82868584	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr11:82868584C>G	uc001ozx.3	+	1	448	c.103C>G	c.(103-105)CCG>GCG	p.P35A	PCF11_uc010rsu.1_Missense_Mutation_p.P35A|PCF11_uc001ozy.2_Missense_Mutation_p.P35A	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	35	CID.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						CAATAGCAAGCCGCACATCAA	0.587000												
PCF11	51585	broad.mit.edu	37	11	82868592	82868592	+	Silent	SNP	C	C	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr11:82868592C>T	uc001ozx.3	+	1	456	c.111C>T	c.(109-111)ATC>ATT	p.I37I	PCF11_uc010rsu.1_Silent_p.I37I|PCF11_uc001ozy.2_Silent_p.I37I	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	37	CID.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						AGCCGCACATCAATATGCTGA	0.597000												
SIK3	23387	broad.mit.edu	37	11	116730231	116730231	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr11:116730231C>T	uc001ppy.2	-	19	2233	c.2197G>A	c.(2197-2199)GTG>ATG	p.V733M	SIK3_uc001ppz.2_Missense_Mutation_p.V632M|SIK3_uc001pqa.2_Missense_Mutation_p.V733M|SIK3_uc001ppw.2_Missense_Mutation_p.V150M|SIK3_uc001ppx.2_Missense_Mutation_p.V171M|SIK3_uc001pqb.2_Missense_Mutation_p.V36M	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	733	Gln-rich.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						GTTAGTGCCACGTTGGGAGGA	0.542000											OREG0003491	type=REGULATORY REGION|Gene=AK022302|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay
VWF	7450	broad.mit.edu	37	12	6128084	6128084	+	Silent	SNP	C	C	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr12:6128084C>T	uc001qnn.1	-	28	4750	c.4500G>A	c.(4498-4500)GCG>GCA	p.A1500A	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1500	VWFA 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CCAGGACGAACGCCACATCCA	0.587000												
FREM2	341640	broad.mit.edu	37	13	39264487	39264487	+	Silent	SNP	G	G	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr13:39264487G>A	uc001uwv.2	+	1	3315	c.3006G>A	c.(3004-3006)GAG>GAA	p.E1002E		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1002	CSPG 6.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TTCCAGCAGAGCAGTTTACTC	0.453000												
C14orf106	55320	broad.mit.edu	37	14	45693557	45693557	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr14:45693557T>C	uc001wwf.2	-	11	2692	c.2233A>G	c.(2233-2235)ACC>GCC	p.T745A		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	745					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						AATAGTCTGGTATTTTTCTTA	0.343000												
SMAD3	4088	broad.mit.edu	37	15	67479784	67479784	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr15:67479784A>G	uc002aqj.2	+	8	1389	c.1091A>G	c.(1090-1092)TAC>TGC	p.Y364C	SMAD3_uc010ujr.1_Missense_Mutation_p.Y259C|SMAD3_uc010ujs.1_Missense_Mutation_p.Y320C|SMAD3_uc010ujt.1_Missense_Mutation_p.Y169C	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	364	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		GAGGCTGTCTACCAGTTGACC	0.557000												
HAPLN3	145864	broad.mit.edu	37	15	89421430	89421430	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr15:89421430G>A	uc002bnc.2	-	5	982	c.854C>T	c.(853-855)GCC>GTC	p.A285V	HAPLN3_uc002bne.2_RNA|HAPLN3_uc002bnd.2_Missense_Mutation_p.A347V	NM_178232	NP_839946	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	285	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	Lung NSC(78;0.0392)|all_lung(78;0.077)					TTCCTGGCAGGCCTCCCTTGC	0.652000												
ALDH1A3	220	broad.mit.edu	37	15	101447328	101447328	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr15:101447328T>G	uc002bwn.3	+	11	1340	c.1236T>G	c.(1234-1236)ATT>ATG	p.I412M	ALDH1A3_uc010bpb.2_Missense_Mutation_p.I305M|uc002bwo.1_Intron	NM_000693	NP_000684	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1A3	412					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			central_nervous_system(2)|lung(1)|pancreas(1)	4	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	AATCATAGATTTTCGGGCCAG	0.408000												
SLC7A6	9057	broad.mit.edu	37	16	68330347	68330347	+	Missense_Mutation	SNP	C	C	A	rs149574667		TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr16:68330347C>A	uc002evt.1	+	10	1509	c.1200C>A	c.(1198-1200)TTC>TTA	p.F400L	SLC7A6_uc002evu.1_Missense_Mutation_p.F400L|SLC7A6_uc002evv.1_RNA|SLC7A6_uc010cfc.1_RNA	NM_001076785	NP_001070253	Q92536	YLAT2_HUMAN	solute carrier family 7 (cationic amino acid	400	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		ACTGGTTCTTCGTGGGCCTGT	0.577000												
CDH1	999	broad.mit.edu	37	16	68844172	68844172	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr16:68844172G>T	uc002ewg.1	+	6	884	c.760G>T	c.(760-762)GAT>TAT	p.D254Y	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.D254Y	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	254	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.?(2)|p.D254fs*9(1)|p.D254H(1)|p.D254Y(1)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		CACGGTAACCGATCAGAATGA	0.468000			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer			
GAN	8139	broad.mit.edu	37	16	81399030	81399030	+	Silent	SNP	G	G	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr16:81399030G>A	uc002fgo.2	+	9	1597	c.1449G>A	c.(1447-1449)CAG>CAA	p.Q483Q		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	483	Kelch 5.				cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)				AGGACGCCCAGGGTAGCGAGA	0.488000												
SLC13A5	284111	broad.mit.edu	37	17	6607292	6607292	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr17:6607292A>T	uc002gdj.2	-	4	540	c.452T>A	c.(451-453)ATC>AAC	p.I151N	SLC13A5_uc010vtf.1_Missense_Mutation_p.I151N|SLC13A5_uc010clq.2_Missense_Mutation_p.I108N|SLC13A5_uc002gdk.2_Missense_Mutation_p.I134N|SLC13A5_uc002gdl.1_Missense_Mutation_p.I133N	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	151						integral to membrane	citrate transmembrane transporter activity				0						GGCCTCCACGATGGGCACCAT	0.632000												
RGS9	8787	broad.mit.edu	37	17	63221598	63221598	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr17:63221598T>C	uc002jfe.2	+	18	1996	c.1886T>C	c.(1885-1887)GTA>GCA	p.V629A	RGS9_uc010dem.2_Missense_Mutation_p.V626A|RGS9_uc002jfd.2_Missense_Mutation_p.V626A|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Missense_Mutation_p.V400A	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	629					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						TCCAAGAGAGTAGCAAAGTAA	0.607000												
DCC	1630	broad.mit.edu	37	18	50592506	50592506	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr18:50592506A>G	uc002lfe.1	+	7	1818	c.1231A>G	c.(1231-1233)ACC>GCC	p.T411A	DCC_uc010xdr.1_Missense_Mutation_p.T259A|DCC_uc010dpf.1_Missense_Mutation_p.T66A	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	411	Extracellular (Potential).|Ig-like C2-type 4.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AAATGCCCAGACCAGTGCACA	0.443000												
EEF2	1938	broad.mit.edu	37	19	3982022	3982022	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr19:3982022T>C	uc002lze.2	-	6	903	c.820A>G	c.(820-822)AGC>GGC	p.S274G		NM_001961	NP_001952	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	274						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGACTTGCTGAACTTGCCG	0.602000												
ZNF93	81931	broad.mit.edu	37	19	20045214	20045214	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr19:20045214G>A	uc002non.2	+	4	1561	c.1450G>A	c.(1450-1452)GAA>AAA	p.E484K		NM_031218	NP_112495	P35789	ZNF93_HUMAN	zinc finger protein 93	484	C2H2-type 13.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1						CTACAAATGTGAAGAATGTGG	0.383000												
RBM42	79171	broad.mit.edu	37	19	36128216	36128216	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr19:36128216A>G	uc002oan.2	+	9	1368	c.1292A>G	c.(1291-1293)GAC>GGC	p.D431G	RBM42_uc010eef.2_Missense_Mutation_p.D377G|RBM42_uc002oao.2_Missense_Mutation_p.D409G|RBM42_uc002oap.2_Missense_Mutation_p.D401G|RBM42_uc002oaq.2_Missense_Mutation_p.D402G|RBM42_uc010eeg.2_Intron	NM_024321	NP_077297	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	431	Necessary for interaction with HNRNPK (By similarity).|RRM.					cytoplasm|nucleus	nucleotide binding|RNA binding				0	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			AGCTTCAAGGACCCCAGCGAC	0.647000												
SCN7A	6332	broad.mit.edu	37	2	167262220	167262220	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr2:167262220C>T	uc002udu.1	-	25	5046	c.4919G>A	c.(4918-4920)CGC>CAC	p.R1640H		NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1640					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TCGCCTCAAGCGGTAATTTTT	0.368000												
ELFN2	114794	broad.mit.edu	37	22	37771219	37771219	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr22:37771219G>A	uc003asq.3	-	3	1142	c.356C>T	c.(355-357)ACG>ATG	p.T119M		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	119	LRR 3.|Extracellular (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					CATGCCCTCCGTCAGGTTGCT	0.622000												
CARD10	29775	broad.mit.edu	37	22	37903838	37903838	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr22:37903838G>C	uc003asx.1	-	6	1192	c.1189C>G	c.(1189-1191)CAG>GAG	p.Q397E	CARD10_uc003ast.1_RNA|CARD10_uc003asw.1_Missense_Mutation_p.Q111E|CARD10_uc003asy.1_Missense_Mutation_p.Q397E	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	397	Potential.				activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					GGGCTCACCTGGTCTCGCTCC	0.597000												
HDAC10	83933	broad.mit.edu	37	22	50686482	50686482	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr22:50686482C>A	uc003bkg.2	-	13	1547	c.1174G>T	c.(1174-1176)GCA>TCA	p.A392S	HDAC10_uc003bke.2_Missense_Mutation_p.A118S|HDAC10_uc003bkf.2_Missense_Mutation_p.A118S|HDAC10_uc010hav.2_Missense_Mutation_p.A372S|HDAC10_uc003bkh.2_Missense_Mutation_p.A185S|HDAC10_uc003bki.2_Missense_Mutation_p.A342S|HDAC10_uc003bkj.2_RNA|HDAC10_uc003bkk.1_Missense_Mutation_p.A26S	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	392					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGTGCAGATGCAGCTGCCTTA	0.652000												
FAM3D	131177	broad.mit.edu	37	3	58625893	58625893	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr3:58625893C>T	uc003dkq.2	-	7	631	c.334G>A	c.(334-336)GCT>ACT	p.A112T		NM_138805	NP_620160	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	112					negative regulation of insulin secretion	extracellular region	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		CCCAGCACAGCTCCCGTGGTT	0.532000												
ACAD11	84129	broad.mit.edu	37	3	132350306	132350306	+	Silent	SNP	C	C	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr3:132350306C>T	uc003eov.3	-	6	1100	c.720G>A	c.(718-720)GTG>GTA	p.V240V	ACAD11_uc003eoy.2_Silent_p.V240V	NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	240						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1						CCCAATCCAGCACTGCTATAA	0.343000												
PDE4D	5144	broad.mit.edu	37	5	58273028	58273028	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr5:58273028A>G	uc003jsa.2	-	12	1869	c.1697T>C	c.(1696-1698)GTC>GCC	p.V566A	PDE4D_uc003jrx.2_Missense_Mutation_p.V430A|PDE4D_uc003jry.2_Missense_Mutation_p.V264A|PDE4D_uc003jrz.2_Missense_Mutation_p.V502A|PDE4D_uc003jsb.2_Missense_Mutation_p.V505A|PDE4D_uc003jrt.2_Missense_Mutation_p.V264A|PDE4D_uc003jru.2_Missense_Mutation_p.V342A|PDE4D_uc003jrv.2_Missense_Mutation_p.V436A|PDE4D_uc003jrw.2_Missense_Mutation_p.V444A|PDE4D_uc003jrs.2_Missense_Mutation_p.V275A	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	566					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	GATGTCAATGACCATTTTCCT	0.338000												
F2R	2149	broad.mit.edu	37	5	76029103	76029103	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr5:76029103T>A	uc003ken.3	+	2	1318	c.1053T>A	c.(1051-1053)TTT>TTA	p.F351L		NM_001992	NP_001983	P25116	PAR1_HUMAN	coagulation factor II receptor precursor	351	Helical; Name=7; (Potential).				activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			ovary(3)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	CTGCCTACTTTGCCTACCTCC	0.488000												
CDHR2	54825	broad.mit.edu	37	5	176017146	176017146	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr5:176017146C>T	uc003mem.1	+	25	3340	c.3274C>T	c.(3274-3276)CGG>TGG	p.R1092W	CDHR2_uc003men.1_Missense_Mutation_p.R1092W	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	1092	Extracellular (Potential).				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						TTCTGCAGCTCGGTGAGTGCC	0.587000												
IRF4	3662	broad.mit.edu	37	6	401655	401655	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr6:401655C>T	uc003msz.3	+	7	1090	c.977C>T	c.(976-978)GCG>GTG	p.A326V	IRF4_uc010jne.1_Missense_Mutation_p.A326V|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Missense_Mutation_p.A325V|IRF4_uc003mtc.1_Missense_Mutation_p.A156V	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	326					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		GGGCTCTATGCGAAAAGACTG	0.602000			T	IGH@	MM 							
ORC3L	23595	broad.mit.edu	37	6	88318928	88318928	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr6:88318928G>C	uc003pmh.2	+	7	738	c.694G>C	c.(694-696)GAC>CAC	p.D232H	ORC3L_uc011dzl.1_Missense_Mutation_p.D232H|ORC3L_uc011dzm.1_Missense_Mutation_p.D232H|ORC3L_uc011dzn.1_RNA|ORC3L_uc003pmg.2_Missense_Mutation_p.D232H|ORC3L_uc003pmi.2_Missense_Mutation_p.D232H|ORC3L_uc011dzo.1_Missense_Mutation_p.D89H|ORC3L_uc011dzp.1_Missense_Mutation_p.D89H	NM_012381	NP_036513	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3 isoform 2	232					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0		all_cancers(76;9.05e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.0469)		AGTACTACAAGACTTCATAAT	0.348000												
AMZ1	155185	broad.mit.edu	37	7	2740225	2740225	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr7:2740225C>T	uc003smr.1	+	2	501	c.140C>T	c.(139-141)GCC>GTC	p.A47V	AMZ1_uc003sms.1_Missense_Mutation_p.A47V|AMZ1_uc011jwa.1_5'Flank	NM_133463	NP_597720	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	47							metallopeptidase activity|zinc ion binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		CTGGCCGAGGCCTACAACCCG	0.667000												
PLXNA4	91584	broad.mit.edu	37	7	131883272	131883272	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr7:131883272A>C	uc003vra.3	-	13	2939	c.2710T>G	c.(2710-2712)TTA>GTA	p.L904V		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	904	IPT/TIG 1.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CCATCCACTAAAGGGCTGCAC	0.562000												
SSPO	23145	broad.mit.edu	37	7	149498906	149498906	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr7:149498906C>A	uc010lpk.2	+	51	7358	c.7358C>A	c.(7357-7359)GCC>GAC	p.A2453D		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2453					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCTACCATGGCCCTGCCTGGG	0.622000												
PENK	5179	broad.mit.edu	37	8	57354302	57354302	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr8:57354302C>A	uc003xsz.2	-	2	414	c.333G>T	c.(331-333)ATG>ATT	p.M111I	PENK_uc003xta.3_Missense_Mutation_p.M111I	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	111					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			CCATTTTCTTCATGAAGCCTC	0.488000												
SULF1	23213	broad.mit.edu	37	8	70488242	70488242	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr8:70488242G>A	uc010lza.1	+	6	927	c.210G>A	c.(208-210)ATG>ATA	p.M70I	SULF1_uc003xyd.2_Missense_Mutation_p.M70I|SULF1_uc003xye.2_Missense_Mutation_p.M70I|SULF1_uc003xyf.2_Missense_Mutation_p.M70I|SULF1_uc003xyg.2_Missense_Mutation_p.M70I	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	70					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			GAAAGATTATGGAACATGGGG	0.498000												
ZNF572	137209	broad.mit.edu	37	8	125989941	125989941	+	Silent	SNP	C	C	T			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr8:125989941C>T	uc003yrr.2	+	3	1586	c.1431C>T	c.(1429-1431)TTC>TTT	p.F477F		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	477	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			AGAAATGCTTCAGCAGAAGTG	0.458000										HNSCC(60;0.17)		
MLLT3	4300	broad.mit.edu	37	9	20346483	20346483	+	Silent	SNP	G	G	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr9:20346483G>A	uc003zoe.2	-	11	1924	c.1665C>T	c.(1663-1665)GTC>GTT	p.V555V	MLLT3_uc011lne.1_Silent_p.V523V|MLLT3_uc011lnf.1_Silent_p.V552V	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	555					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		GTAGTTTACGGACTGTGGTTT	0.353000			T	MLL	ALL							
TOPORS	10210	broad.mit.edu	37	9	32543727	32543727	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr9:32543727C>G	uc003zrb.2	-	3	963	c.796G>C	c.(796-798)GGT>CGT	p.G266R	TOPORS_uc003zrc.2_Missense_Mutation_p.G199R	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	266	Required for DNA-binding.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		ACTCGAGCACCAGCACGATAA	0.413000												
DBC1	1620	broad.mit.edu	37	9	121929759	121929759	+	Missense_Mutation	SNP	C	C	T	rs151087333		TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr9:121929759C>T	uc004bkc.2	-	8	2345	c.1889G>A	c.(1888-1890)CGA>CAA	p.R630Q		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	630					cell cycle arrest|cell death	cytoplasm	protein binding	p.R630Q(1)		skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						AGTCTCATTTCGCAGTAGGGT	0.537000												
CLCN5	1184	broad.mit.edu	37	X	49834605	49834605	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chrX:49834605C>A	uc004dos.1	+	2	273	c.25C>A	c.(25-27)CCT>ACT	p.P9T	CLCN5_uc004dor.1_Missense_Mutation_p.P79T|CLCN5_uc004doq.1_Missense_Mutation_p.P79T|CLCN5_uc004dot.1_Missense_Mutation_p.P9T	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	9	Cytoplasmic (By similarity).				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					GGAGCCAATCCCTGGTGTAGG	0.438000												
MAGED1	9500	broad.mit.edu	37	X	51640687	51640687	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chrX:51640687G>A	uc004dpm.2	+	6	1626	c.1531G>A	c.(1531-1533)GAA>AAA	p.E511K	MAGED1_uc004dpn.2_Missense_Mutation_p.E567K|MAGED1_uc004dpo.2_Missense_Mutation_p.E511K	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	511	MAGE.				apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)					TGTTTATCCAGAAATCATTGA	0.493000										Multiple Myeloma(10;0.10)		
ATRX	546	broad.mit.edu	37	X	76937284	76937284	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chrX:76937284G>C	uc004ecp.3	-	9	3696	c.3464C>G	c.(3463-3465)TCA>TGA	p.S1155*	ATRX_uc004ecq.3_Nonsense_Mutation_p.S1117*|ATRX_uc004eco.3_Nonsense_Mutation_p.S940*|ATRX_uc004ecr.2_Nonsense_Mutation_p.S1087*|ATRX_uc010nlx.1_Nonsense_Mutation_p.S1126*|ATRX_uc010nly.1_Nonsense_Mutation_p.S1100*	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1155	Poly-Ser.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AGCATCAGATGATGATGAGCC	0.333000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome					
FMR1	2332	broad.mit.edu	37	X	147007065	147007065	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chrX:147007065C>G	uc010nst.2	+	3	301	c.112C>G	c.(112-114)CCT>GCT	p.P38A	FMR1_uc011mwz.1_Missense_Mutation_p.P38A|FMR1_uc004fcj.2_Missense_Mutation_p.P38A|FMR1_uc004fck.3_Missense_Mutation_p.P38A|FMR1_uc004fcl.3_5'Flank	NM_002024	NP_002015	Q06787	FMR1_HUMAN	fragile X mental retardation 1	38					mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CAGCTGGCAGCCTGATAGGCA	0.368000									Fragile_X_syndrome			
RTN4RL2	349667	broad.mit.edu	37	11	57244172	57244175	+	Frame_Shift_Del	DEL	CTGC	CTGC	-			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr11:57244172_57244175delCTGC	uc010rjt.1	+	3	1051_1054	c.1051_1054delCTGC	c.(1051-1056)CTGCCTfs	p.L351fs		NM_178570	NP_848665	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2 precursor	351_352					axon regeneration	anchored to plasma membrane	receptor activity				0						CTACCGAGATCTGCCTGCCGAAGA	0.632												
INTS6	26512	broad.mit.edu	37	13	51956203	51956203	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr13:51956203delC	uc001vfk.2	-	10	1851	c.1237delG	c.(1237-1239)GAAfs	p.E413fs	INTS6_uc001vfi.2_Frame_Shift_Del_p.E97fs|INTS6_uc001vfj.2_Frame_Shift_Del_p.E400fs|INTS6_uc001vfl.2_Frame_Shift_Del_p.E235fs	NM_012141	NP_036273	Q9UL03	INT6_HUMAN	integrator complex subunit 6 isoform a	413					snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			ovary(1)|lung(1)	2		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		AAATAACTTTCAAATGACTGT	0.259												
PRB2	653247	broad.mit.edu	37	12	11546419	11546421	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-BR-8058-01A-31D-2340-08	TCGA-BR-8058-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd9d9fd4-0aff-4a7d-982f-d87fa38ca5b0	aee74947-0273-4f36-af55-09bc0df09fb1	g.chr12:11546418_11546420TGGA>T	uc010shk.1	-	2	627_629	c.592_594TCCA>A	c.(592-594)cca>A	p.P198del		NM_006248	NP_006239			Homo sapiens proline-rich protein BstNI subfamily 2 (PRB2), mRNA.											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GTGGCTTTCCTGGAGGAGGTGGG	0.586