Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
CAP1	10487	broad.mit.edu	37	1	40536131	40536131	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr1:40536131G>A	uc001cfa.3	+	11	1376	c.1147G>A	c.(1147-1149)GAT>AAT	p.D383N	CAP1_uc001cey.3_Missense_Mutation_p.D383N|CAP1_uc001cez.3_Missense_Mutation_p.D383N|CAP1_uc009vvz.2_Missense_Mutation_p.D383N|CAP1_uc010oje.1_Missense_Mutation_p.D300N	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	383	C-CAP/cofactor C-like.				activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCTGGTATTCGATGACGTGGT	0.378000												
SGIP1	84251	broad.mit.edu	37	1	67199453	67199453	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr1:67199453A>G	uc001dcr.2	+	21	2138	c.1921A>G	c.(1921-1923)AAT>GAT	p.N641D	SGIP1_uc010opd.1_Missense_Mutation_p.N241D|SGIP1_uc001dcs.2_Missense_Mutation_p.N241D|SGIP1_uc001dct.2_Missense_Mutation_p.N243D|SGIP1_uc009wat.2_Missense_Mutation_p.N435D|SGIP1_uc001dcu.2_Missense_Mutation_p.N146D	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	641					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						AAATGATGCCAATACCAAGGA	0.348000												
OR4X1	390113	broad.mit.edu	37	11	48286169	48286169	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr11:48286169T>A	uc010rht.1	+	1	757	c.757T>A	c.(757-759)TCC>ACC	p.S253T		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X,	253	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3						CATACCTTGCTCCTTGGTCTA	0.502000												
KIAA1199	57214	broad.mit.edu	37	15	81225778	81225778	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr15:81225778A>G	uc002bfw.1	+	22	3246	c.2986A>G	c.(2986-2988)ATT>GTT	p.I996V	KIAA1199_uc010unn.1_Missense_Mutation_p.I996V	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	996										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GAGAGGGGCCATTTGCAGTGG	0.483000												
CDH1	999	broad.mit.edu	37	16	68842463	68842463	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr16:68842463T>C	uc002ewg.1	+	4	648	c.524T>C	c.(523-525)CTG>CCG	p.L175P	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.L175P	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	175	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.V157_Q177del(1)|p.N174fs*38(1)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		CCTAAAAACCTGGTTCAGGTA	0.473000			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer			
ZNF521	25925	broad.mit.edu	37	18	22807194	22807194	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr18:22807194C>G	uc002kvk.2	-	4	935	c.688G>C	c.(688-690)GGC>CGC	p.G230R	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.G230R|ZNF521_uc002kvl.2_Missense_Mutation_p.G10R	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	230					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GACTGAGAGCCGTCCTTGTTC	0.512000			T	PAX5	ALL							
LPPR3	79948	broad.mit.edu	37	19	815788	815788	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr19:815788G>A	uc002lpx.1	-	3	203	c.139C>T	c.(139-141)CCG>TCG	p.P47S	LPPR3_uc010dru.1_5'Flank|LPPR3_uc002lpw.1_Missense_Mutation_p.P47S|LPPR3_uc002lpy.1_5'UTR	NM_024888	NP_079164	Q6T4P5	LPPR3_HUMAN	plasticity-related protein 2	47						integral to membrane	phosphatidate phosphatase activity				0						ACCTTGGCCGGCTTGAAGAGG	0.597000												
UPF1	5976	broad.mit.edu	37	19	18956872	18956872	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr19:18956872C>G	uc002nkg.2	+	2	590	c.315C>G	c.(313-315)TTC>TTG	p.F105L	UPF1_uc002nkf.2_Missense_Mutation_p.F105L	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	105	Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AGTTGAACTTCGAGGAAGATG	0.582000												
GPR39	2863	broad.mit.edu	37	2	133174712	133174712	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr2:133174712C>G	uc002ttl.2	+	1	566	c.97C>G	c.(97-99)CTT>GTT	p.L33V		NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	33	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						CAAAATCACCCTTATTCTGGT	0.537000												
SIGLEC1	6614	broad.mit.edu	37	20	3672111	3672111	+	Silent	SNP	G	G	A			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr20:3672111G>A	uc002wja.2	-	17	4467	c.4467C>T	c.(4465-4467)CAC>CAT	p.H1489H	SIGLEC1_uc002wjb.1_Silent_p.H128H|SIGLEC1_uc002wiz.3_Silent_p.H1489H	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1489	Ig-like C2-type 15.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						CAGGCTCCGCGTGCAGCCGCC	0.672000												
ITIH1	3697	broad.mit.edu	37	3	52819116	52819116	+	Silent	SNP	C	C	T			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr3:52819116C>T	uc003dfs.2	+	12	1488	c.1464C>T	c.(1462-1464)CCC>CCT	p.P488P	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Silent_p.P89P|ITIH1_uc010hmo.1_Silent_p.P42P|ITIH1_uc003dfu.2_5'Flank	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	488	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		TGCAGTACCCCCAGGATGCTG	0.562000												
PHLDB2	90102	broad.mit.edu	37	3	111692580	111692580	+	Silent	SNP	C	C	T			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr3:111692580C>T	uc010hqa.2	+	17	3948	c.3537C>T	c.(3535-3537)GAC>GAT	p.D1179D	PHLDB2_uc003dyc.2_Silent_p.D1163D|PHLDB2_uc003dyd.2_Silent_p.D1136D|PHLDB2_uc003dyg.2_Silent_p.D1179D|PHLDB2_uc003dyh.2_Silent_p.D1136D|PHLDB2_uc003dyi.2_Silent_p.D670D|PHLDB2_uc003dyj.2_Silent_p.D234D	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1179	PH.					cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						TCTTTGCAGACAAGCATGAAA	0.254000												
PIK3CB	5291	broad.mit.edu	37	3	138374293	138374293	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr3:138374293C>T	uc011bmq.1	-	22	3151	c.3151G>A	c.(3151-3153)GAA>AAA	p.E1051K	PIK3CB_uc011bmn.1_Missense_Mutation_p.E563K|PIK3CB_uc011bmo.1_Missense_Mutation_p.E502K|PIK3CB_uc011bmp.1_Missense_Mutation_p.E638K|PIK3CB_uc003est.1_RNA	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	1051	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GTCCAGCTTTCCCTGAGCGCC	0.423000												
PCDHB12	56124	broad.mit.edu	37	5	140588900	140588900	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr5:140588900G>C	uc003liz.2	+	1	610	c.421G>C	c.(421-423)GAA>CAA	p.E141Q	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	141	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATGCTCTTAGAAATCCCAGA	0.393000												
TTBK1	84630	broad.mit.edu	37	6	43214429	43214429	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr6:43214429G>A	uc003ouq.1	+	2	310	c.31G>A	c.(31-33)GAA>AAA	p.E11K		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	11						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CCTTAAGGACGAAACCAACAT	0.667000												
COL12A1	1303	broad.mit.edu	37	6	75884763	75884763	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr6:75884763T>C	uc003phs.2	-	13	2867	c.2701A>G	c.(2701-2703)ACA>GCA	p.T901A	COL12A1_uc003pht.2_Intron	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	901	Fibronectin type-III 5.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CCTTCAAGTGTTGTTCCTTCA	0.453000												
COL28A1	340267	broad.mit.edu	37	7	7412686	7412686	+	Silent	SNP	G	G	A			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr7:7412686G>A	uc003src.1	-	32	2968	c.2851C>T	c.(2851-2853)CTA>TTA	p.L951L	COL28A1_uc011jxe.1_Silent_p.L634L	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	951	VWFA 2.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GTAGCAATTAGATTCATTTCT	0.418000												
PHYHIP	9796	broad.mit.edu	37	8	22079030	22079030	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr8:22079030G>A	uc003xbk.3	-	6	1523	c.829C>T	c.(829-831)CGC>TGC	p.R277C	PHYHIP_uc003xbj.3_Missense_Mutation_p.R277C	NM_001099335	NP_001092805	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	277											0				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		TGGGCGTGGCGGAAGACCAGC	0.642000												
RIMS2	9699	broad.mit.edu	37	8	105257239	105257239	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr8:105257239C>T	uc003yls.2	+	24	3725	c.3484C>T	c.(3484-3486)CGA>TGA	p.R1162*	RIMS2_uc003ylp.2_Nonsense_Mutation_p.R1144*|RIMS2_uc003ylw.2_Nonsense_Mutation_p.R1151*|RIMS2_uc003ylq.2_Nonsense_Mutation_p.R958*|RIMS2_uc003ylr.2_Nonsense_Mutation_p.R983*	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1206					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ACAGGCAAGCCGAGAGTCTAC	0.507000										HNSCC(12;0.0054)		
IPPK	64768	broad.mit.edu	37	9	95396678	95396678	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr9:95396678G>A	uc004asl.1	-	11	1437	c.1160C>T	c.(1159-1161)GCG>GTG	p.A387V	IPPK_uc004ask.1_Missense_Mutation_p.A86V	NM_022755	NP_073592	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	387					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			ovary(2)	2						CTTCGTTAGCGCGAAGGCCAC	0.408000											OREG0019315	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
COL5A1	1289	broad.mit.edu	37	9	137622102	137622102	+	Silent	SNP	G	G	A	rs149123775		TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr9:137622102G>A	uc004cfe.2	+	7	1327	c.945G>A	c.(943-945)ACG>ACA	p.T315T		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	315	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CGACCCCCACGGAAGCTGCTC	0.642000												
PC	5091	broad.mit.edu	37	11	66639596	66639597	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr11:66639596_66639597delCT	uc001ojn.1	-	2	83_84	c.34_35delAG	c.(34-36)AGGfs	p.R12fs	PC_uc001ojo.1_Frame_Shift_Del_p.R12fs|PC_uc001ojp.1_Frame_Shift_Del_p.R12fs	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	12					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	TCCCAGGAGCCTCAGGCCCCCA	0.599												
AATK	9625	broad.mit.edu	37	17	79094536	79094536	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr17:79094536delG	uc010dia.2	-	11	3280	c.3200delC	c.(3199-3201)CCAfs	p.P1067fs	AATK_uc010dhz.2_Intron	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	1067	Pro-rich.					integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GCTGGGCTCTGGGGAGGACCC	0.706												
SIK1	150094	broad.mit.edu	37	21	44836942	44836942	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-8364-01A-11D-2340-08	TCGA-BR-8364-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31604e3a-9873-4f4c-9e47-e503ee4503ad	a48dc850-ad6d-4715-bf12-610020a4f411	g.chr21:44836942delG	uc002zdf.2	-	14	2159	c.2032delC	c.(2032-2034)CAGfs	p.Q678fs		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	678					anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7						GGGGCCGGCTGGGGGGCCTGG	0.736