Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
PTCHD2	57540	broad.mit.edu	37	1	11579842	11579842	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:11579842A>T	uc001ash.3	+	9	2243	c.2105A>T	c.(2104-2106)AAC>ATC	p.N702I	PTCHD2_uc001asi.1_Missense_Mutation_p.N702I	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	702	Cytoplasmic (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CCAGCCTCCAACACGGGCAGC	0.657												
RPE65	6121	broad.mit.edu	37	1	68910260	68910260	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:68910260T>A	uc001dei.1	-	5	503	c.449A>T	c.(448-450)AAC>ATC	p.N150I		NM_000329	NP_000320	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein	150					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			ovary(1)	1						TGTAATAAAGTTGGTCTCTGT	0.398												
AMY2B	280	broad.mit.edu	37	1	104122045	104122045	+	Missense_Mutation	SNP	G	G	A	rs150795802		TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:104122045G>A	uc001duq.2	+	12	2075	c.1459G>A	c.(1459-1461)GAT>AAT	p.D487N	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.D487N|AMY2B_uc001dus.1_Intron	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	487					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		CGTTTCTGACGATGGCAAAGC	0.338												
SF3B4	10262	broad.mit.edu	37	1	149898269	149898269	+	Silent	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:149898269T>C	uc001etj.1	-	3	756	c.705A>G	c.(703-705)CCA>CCG	p.P235P	SF3B4_uc001eti.1_5'Flank|SF3B4_uc001etk.1_Silent_p.P235P|SF3B4_uc009wll.1_Silent_p.P235P	NM_005850	NP_005841	Q15427	SF3B4_HUMAN	splicing factor 3b, subunit 4	235						nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			AAGCTTTACCTGGTGGAGGAA	0.517												
FCRL2	79368	broad.mit.edu	37	1	157738349	157738349	+	Silent	SNP	G	G	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:157738349G>T	uc001fre.2	-	5	797	c.738C>A	c.(736-738)ACC>ACA	p.T246T	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Silent_p.T246T|FCRL2_uc009wsp.2_Intron	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	246	Ig-like C2-type 3.|Extracellular (Potential).				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TTCCCATACTGGTTCCTGTGG	0.522												
CD5L	922	broad.mit.edu	37	1	157803288	157803288	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:157803288T>C	uc001frk.3	-	5	876	c.733A>G	c.(733-735)AGA>GGA	p.R245G		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	245	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCTACTAGTCTCAAGTCAAAG	0.478												
SLC9A11	284525	broad.mit.edu	37	1	173506170	173506170	+	Silent	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:173506170A>G	uc001giz.2	-	14	1989	c.1566T>C	c.(1564-1566)TTT>TTC	p.F522F	SLC9A11_uc009wwe.2_Silent_p.F80F|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	522					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						GCTGTTTTTCAAAGCTACTCT	0.333												
STX6	10228	broad.mit.edu	37	1	180957480	180957480	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:180957480A>C	uc010pnq.1	-	6	728	c.491T>G	c.(490-492)TTG>TGG	p.L164W	STX6_uc001goo.2_Missense_Mutation_p.L164W|STX6_uc010pnr.1_Missense_Mutation_p.L63W	NM_005819	NP_005810	O43752	STX6_HUMAN	syntaxin 6	164	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				Golgi vesicle transport|intracellular protein transport|vesicle fusion	clathrin-coated vesicle|early endosome|integral to membrane|perinuclear region of cytoplasm|plasma membrane|trans-Golgi network membrane	SNAP receptor activity			ovary(1)	1						TTCCACGATCAACTGGTGCCA	0.527												
NFASC	23114	broad.mit.edu	37	1	204944442	204944442	+	Silent	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:204944442A>G	uc001hbj.2	+	15	1930	c.1602A>G	c.(1600-1602)AGA>AGG	p.R534R	NFASC_uc001hbh.2_Silent_p.R534R|NFASC_uc010pqz.1_Silent_p.R528R|NFASC_uc010pra.1_Silent_p.R545R|NFASC_uc001hbi.2_Silent_p.R545R|NFASC_uc010prb.1_Silent_p.R545R|NFASC_uc010prc.1_Silent_p.R101R|NFASC_uc001hbk.1_Silent_p.R355R	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	534	Extracellular (Potential).|Ig-like C2-type 6.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGGTGGCCAGAAGGGGCACCA	0.622											OREG0014142	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
TGFB2	7042	broad.mit.edu	37	1	218520217	218520217	+	Silent	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:218520217T>G	uc001hlm.2	+	1	827	c.174T>G	c.(172-174)CCT>CCG	p.P58P	TGFB2_uc001hll.2_Silent_p.P58P|TGFB2_uc001hln.2_Silent_p.P58P|TGFB2_uc010pue.1_RNA|TGFB2_uc001hlo.2_RNA	NM_003238	NP_003229	P61812	TGFB2_HUMAN	transforming growth factor, beta 2 isoform 2	58					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding				0				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		AAGACTATCCTGAGCCCGAGG	0.627												
AHCTF1	25909	broad.mit.edu	37	1	247006019	247006019	+	Silent	SNP	C	C	T	rs143813373	byFrequency	TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:247006019C>T	uc001ibu.1	-	34	6592	c.6585G>A	c.(6583-6585)ACG>ACA	p.T2195T	AHCTF1_uc001ibv.1_Silent_p.T2204T|AHCTF1_uc009xgs.1_Intron	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	2195	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TTGTTTTTGACGTCCTGATTC	0.363												
VN1R5	317705	broad.mit.edu	37	1	247419884	247419884	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:247419884T>C	uc010pyu.1	+	2	511	c.511T>C	c.(511-513)TCA>CCA	p.S171P		NM_173858	NP_776257	Q7Z5H4	VN1R5_HUMAN	vomeronasal 1 receptor 5	171	Helical; Name=5; (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0	all_cancers(71;5.7e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)	all_cancers(173;0.0314)	OV - Ovarian serous cystadenocarcinoma(106;0.00854)			CTTCCTTTTCTCATGGGTCCT	0.498												
NLRP3	114548	broad.mit.edu	37	1	247588601	247588601	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:247588601A>C	uc001icr.2	+	5	1994	c.1856A>C	c.(1855-1857)AAA>ACA	p.K619T	NLRP3_uc001ics.2_Missense_Mutation_p.K619T|NLRP3_uc001icu.2_Missense_Mutation_p.K619T|NLRP3_uc001icw.2_Missense_Mutation_p.K619T|NLRP3_uc001icv.2_Missense_Mutation_p.K619T|NLRP3_uc010pyw.1_Missense_Mutation_p.K617T|NLRP3_uc001ict.1_Missense_Mutation_p.K617T	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	619					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GCCAAAGCTAAAAAGCTGCAG	0.483												
OR2G2	81470	broad.mit.edu	37	1	247752318	247752318	+	Silent	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr1:247752318C>T	uc010pyy.1	+	1	657	c.657C>T	c.(655-657)GTC>GTT	p.V219V		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	219	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TCATCCTGGTCTCCTCTGGCT	0.478												
NEBL	10529	broad.mit.edu	37	10	21101765	21101765	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr10:21101765G>T	uc001iqi.2	-	24	2848	c.2451C>A	c.(2449-2451)AGC>AGA	p.S817R	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Missense_Mutation_p.S154R	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	817	Nebulin 23.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						AGGCAGCATCGCTGACCACCT	0.517												
PTF1A	256297	broad.mit.edu	37	10	23482704	23482704	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr10:23482704G>T	uc001irp.2	+	2	856	c.856G>T	c.(856-858)GAA>TAA	p.E286*		NM_178161	NP_835455	Q7RTS3	PTF1A_HUMAN	pancreas specific transcription factor, 1a	286					endocrine pancreas development|exocrine pancreas development|regulation of transcription, DNA-dependent|tissue development|transcription, DNA-dependent	cytoplasm|transcription factor complex				pancreas(1)|skin(1)	2						ATGGACTGATGAAAAACAACT	0.498												
GPR158	57512	broad.mit.edu	37	10	25887234	25887234	+	Silent	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr10:25887234C>T	uc001isj.2	+	11	2739	c.2679C>T	c.(2677-2679)CAC>CAT	p.H893H	GPR158_uc001isk.2_Silent_p.H268H	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	893	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AAACTGGGCACCCACGAACAT	0.517												
ANKRD30A	91074	broad.mit.edu	37	10	37451723	37451723	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr10:37451723A>G	uc001iza.1	+	17	1880	c.1781A>G	c.(1780-1782)AAG>AGG	p.K594R		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	650						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GAAATGCAAAAGTCTGTCCCA	0.308												
ATRNL1	26033	broad.mit.edu	37	10	116930868	116930868	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr10:116930868A>C	uc001lcg.2	+	8	1552	c.1166A>C	c.(1165-1167)AAC>ACC	p.N389T	ATRNL1_uc001lce.2_RNA|ATRNL1_uc001lcf.2_Missense_Mutation_p.N389T|ATRNL1_uc009xyq.2_Missense_Mutation_p.T360P	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	389	Kelch 2.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TGGGTTTTTAACATACATAGT	0.343												
PNLIP	5406	broad.mit.edu	37	10	118321115	118321115	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr10:118321115C>T	uc001lcm.2	+	12	1344	c.1301C>T	c.(1300-1302)TCC>TTC	p.S434F		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	434	PLAT.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	GTGGGAGCATCCAAGATTATA	0.363												
HSPA12A	259217	broad.mit.edu	37	10	118435928	118435928	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr10:118435928T>C	uc001lct.2	-	11	1477	c.1372A>G	c.(1372-1374)AGC>GGC	p.S458G	HSPA12A_uc001lcu.2_Missense_Mutation_p.S375G	NM_025015	NP_079291	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	458							ATP binding			ovary(1)	1				all cancers(201;0.0158)		TCAATGATGCTATCGATGGTC	0.567												
RGS10	6001	broad.mit.edu	37	10	121285571	121285571	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr10:121285571A>C	uc001lee.2	-	2	204	c.204T>G	c.(202-204)GAT>GAG	p.D68E	RGS10_uc001lef.2_Missense_Mutation_p.D62E|RGS10_uc001leg.2_Missense_Mutation_p.D76E	NM_002925	NP_002916	O43665	RGS10_HUMAN	regulator of G-protein signaling 10 isoform b	68	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|protein binding|signal transducer activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00105)|GBM - Glioblastoma multiforme(135;0.195)		TTTTCTTAAAATCTTCACATG	0.323												
INPP5A	3632	broad.mit.edu	37	10	134563341	134563341	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr10:134563341G>A	uc001llp.2	+	11	1143	c.895G>A	c.(895-897)GGC>AGC	p.G299S	INPP5A_uc001llo.1_Missense_Mutation_p.G299S|INPP5A_uc001llq.2_Intron	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	299					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		AGACAACAACGGCACCGCGGT	0.562												
KCNQ1	3784	broad.mit.edu	37	11	2604770	2604770	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr11:2604770C>T	uc001lwn.2	+	7	1135	c.1027C>T	c.(1027-1029)CCA>TCA	p.P343S	KCNQ1_uc009ydp.1_Missense_Mutation_p.P127S|KCNQ1_uc001lwo.2_Missense_Mutation_p.P216S	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	343	Helical; Name=Segment S6; (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	CTTTGCGCTCCCAGCGGTAGG	0.632												
OR52I1	390037	broad.mit.edu	37	11	4615839	4615839	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr11:4615839T>G	uc010qyi.1	+	1	571	c.571T>G	c.(571-573)TTA>GTA	p.L191V		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTTGGCCAGGTTAGCATGTGC	0.493												
OR5D14	219436	broad.mit.edu	37	11	55563231	55563231	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr11:55563231A>G	uc010rim.1	+	1	200	c.200A>G	c.(199-201)CAC>CGC	p.H67R		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				TTCCTTAGTCACCTCTCTTTT	0.383												
RARRES3	5920	broad.mit.edu	37	11	63312231	63312231	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr11:63312231C>T	uc001nxf.3	+	3	325	c.257C>T	c.(256-258)CCA>CTA	p.P86L		NM_004585	NP_004576	Q9UL19	TIG3_HUMAN	retinoic acid receptor responder (tazarotene	86					lipid catabolic process|negative regulation of cell proliferation		hydrolase activity			ovary(1)	1						GAGTACCAACCACGGCCCGTG	0.537												
FOXM1	2305	broad.mit.edu	37	12	2968120	2968120	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr12:2968120A>G	uc001qlf.2	-	9	2241	c.1976T>C	c.(1975-1977)CTC>CCC	p.L659P	uc001qld.2_Intron|FOXM1_uc001qle.2_Missense_Mutation_p.L697P|FOXM1_uc001qlg.2_Missense_Mutation_p.L644P|FOXM1_uc009zea.2_Missense_Mutation_p.L644P|FOXM1_uc009zeb.2_Missense_Mutation_p.L643P	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	659					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			AGTGGTGCTGAGATCCATCAG	0.592												
VWF	7450	broad.mit.edu	37	12	6078421	6078421	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr12:6078421T>G	uc001qnn.1	-	45	7935	c.7685A>C	c.(7684-7686)CAG>CCG	p.Q2562P	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2562					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	ACAGCTCAGCTGAAAGCCCGA	0.587												
PDE3A	5139	broad.mit.edu	37	12	20523121	20523121	+	Silent	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr12:20523121C>T	uc001reh.1	+	1	925	c.903C>T	c.(901-903)TCC>TCT	p.S301S		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	301					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CCGAGATGTCCGGCTGCAGCA	0.587												
GYS2	2998	broad.mit.edu	37	12	21757519	21757519	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr12:21757519C>T	uc001rfb.2	-	1	263	c.8G>A	c.(7-9)CGA>CAA	p.R3Q		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	3					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						GGATCGGCCTCGAAGCATTCT	0.473												
LDHB	3945	broad.mit.edu	37	12	21807527	21807527	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr12:21807527C>T	uc001rfc.2	-	1	97	c.79G>A	c.(79-81)GTG>ATG	p.V27M	LDHB_uc001rfd.2_Missense_Mutation_p.V27M|LDHB_uc001rfe.2_Missense_Mutation_p.V27M	NM_002300	NP_002291	P07195	LDHB_HUMAN	L-lactate dehydrogenase B	27					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity			breast(2)|ovary(1)	3					NADH(DB00157)	CCAACACCCACTACAGTGATC	0.423												
CASC1	55259	broad.mit.edu	37	12	25264751	25264751	+	Silent	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr12:25264751G>A	uc001rgl.2	-	13	1798	c.1716C>T	c.(1714-1716)ATC>ATT	p.I572I	CASC1_uc001rgk.2_Silent_p.I578I|CASC1_uc001rgm.3_Silent_p.I636I|CASC1_uc001rgj.2_Silent_p.I532I|CASC1_uc010sje.1_Silent_p.I513I|CASC1_uc010sjf.1_Silent_p.I460I	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	572										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			TAGTAGGAAAGATATTCAGTC	0.318												
KRAS	3845	broad.mit.edu	37	12	25380275	25380275	+	Missense_Mutation	SNP	T	T	G	rs17851045		TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr12:25380275T>G	uc001rgp.1	-	3	364	c.183A>C	c.(181-183)CAA>CAC	p.Q61H	KRAS_uc001rgq.1_Missense_Mutation_p.Q61H	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	61	GTP.		Q -> R (in a colorectal cancer sample; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.Q61H(140)|p.Q61L(51)|p.Q61R(44)|p.Q61K(24)|p.Q61P(11)|p.Q61E(10)|p.Q61D(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TGTACTCCTCTTGACCTGCTG	0.423	Q61H(T3M4_PANCREAS)|Q61H(HS766T_PANCREAS)|Q61H(NCIH460_LUNG)|Q61H(NCIH1155_LUNG)|Q61H(CL11_LARGE_INTESTINE)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)		
KRT85	3891	broad.mit.edu	37	12	52754645	52754645	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr12:52754645A>G	uc001sag.2	-	9	1636	c.1516T>C	c.(1516-1518)TTT>CTT	p.F506L		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	506	Tail.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TACTAGGCAAAGCGGACCGAC	0.607												
ITGB7	3695	broad.mit.edu	37	12	53587072	53587072	+	Silent	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr12:53587072C>T	uc009zmv.2	-	11	1649	c.1578G>A	c.(1576-1578)GGG>GGA	p.G526G	ITGB7_uc001scc.2_Silent_p.G526G|ITGB7_uc010snz.1_Intron	NM_000889	NP_000880	P26010	ITB7_HUMAN	integrin, beta 7 precursor	526	Cysteine-rich tandem repeats.|Extracellular (Potential).|I.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|breast(1)	8						GAGCCCGGCACCCAGATTCCA	0.632												
TMCC3	57458	broad.mit.edu	37	12	94976127	94976127	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr12:94976127C>T	uc001tdj.2	-	2	384	c.266G>A	c.(265-267)CGC>CAC	p.R89H	TMCC3_uc001tdi.2_Missense_Mutation_p.R58H	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	89						integral to membrane				ovary(1)|skin(1)	2						ATTCCCATCGCGCGATGTTTG	0.448												
VPS29	51699	broad.mit.edu	37	12	110933945	110933945	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr12:110933945T>C	uc001tqy.2	-	2	127	c.67A>G	c.(67-69)AAA>GAA	p.K23E	VPS29_uc001tqw.2_RNA|VPS29_uc001tqx.2_Missense_Mutation_p.K27E|VPS29_uc001tqz.2_RNA	NM_016226	NP_057310	Q9UBQ0	VPS29_HUMAN	vacuolar protein sorting 29 isoform 1	23					protein transport	endosome membrane	metal ion binding|phosphoserine phosphatase activity				0						AGGAGTTTTTTGAATTTAGCT	0.423												
TMEM132B	114795	broad.mit.edu	37	12	126138782	126138782	+	Silent	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr12:126138782G>A	uc001uhe.1	+	9	2771	c.2763G>A	c.(2761-2763)GCG>GCA	p.A921A	TMEM132B_uc001uhf.1_Silent_p.A433A	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	921	Helical; (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		ACTGCGTGGCGTTTGCCTGGA	0.522												
MMP17	4326	broad.mit.edu	37	12	132326256	132326256	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr12:132326256T>C	uc001ujc.1	+	5	893	c.794T>C	c.(793-795)ATC>ACC	p.I265T	MMP17_uc001ujd.1_Missense_Mutation_p.I181T	NM_016155	NP_057239	Q9ULZ9	MMP17_HUMAN	matrix metalloproteinase 17 preproprotein	265					proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		GCACACTCCATCATGCGGCCG	0.642												
SGCG	6445	broad.mit.edu	37	13	23824817	23824817	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr13:23824817C>T	uc001uom.2	+	4	501	c.346C>T	c.(346-348)CGC>TGC	p.R116C	SGCG_uc009zzv.2_Missense_Mutation_p.R116C|SGCG_uc009zzw.2_Missense_Mutation_p.R116C	NM_000231	NP_000222	Q13326	SGCG_HUMAN	gamma sarcoglycan	116	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0		all_cancers(29;4.34e-23)|all_epithelial(30;4.4e-19)|all_lung(29;2.45e-18)|Lung SC(185;0.0228)|Breast(139;0.188)		all cancers(112;0.00255)|Epithelial(112;0.0129)|OV - Ovarian serous cystadenocarcinoma(117;0.0365)|Lung(94;0.205)		TGTAAATGCGCGCAACTCAGA	0.403												
MLNR	2862	broad.mit.edu	37	13	49795336	49795336	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr13:49795336G>A	uc010tgj.1	+	1	863	c.863G>A	c.(862-864)GGG>GAG	p.G288E		NM_001507	NP_001498	O43193	MTLR_HUMAN	motilin receptor	288	Cytoplasmic (Potential).				digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity				0		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		GCCGCCTCGGGGCGGGAGAGA	0.721												
OR11H12	440153	broad.mit.edu	37	14	19378049	19378049	+	Silent	SNP	T	T	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr14:19378049T>A	uc010tkp.1	+	1	456	c.456T>A	c.(454-456)ACT>ACA	p.T152T		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	152	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATATCATGACTGGGCATCTCT	0.478												
PYGL	5836	broad.mit.edu	37	14	51383390	51383390	+	Silent	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr14:51383390A>G	uc001wyu.2	-	9	1189	c.1062T>C	c.(1060-1062)TTT>TTC	p.F354F	PYGL_uc010tqq.1_Silent_p.F320F|PYGL_uc001wyv.2_Silent_p.F28F|PYGL_uc010anz.1_Silent_p.F157F	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	354					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	CAATATCCACAAAAATCCTCA	0.473												
MYO1E	4643	broad.mit.edu	37	15	59548485	59548485	+	Silent	SNP	G	G	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr15:59548485G>T	uc002aga.2	-	4	702	c.330C>A	c.(328-330)ATC>ATA	p.I110I		NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	110	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		CTTCATACCTGATAATGACGC	0.418												
RBPMS2	348093	broad.mit.edu	37	15	65041332	65041332	+	Silent	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr15:65041332G>A	uc002anq.2	-	5	537	c.285C>T	c.(283-285)CCC>CCT	p.P95P		NM_194272	NP_919248	Q6ZRY4	RBPS2_HUMAN	RNA binding protein with multiple splicing 2	95	RRM.						nucleic acid binding|nucleotide binding				0						GTGGATTTTCGGGATCAAAGC	0.512												
NEO1	4756	broad.mit.edu	37	15	73580780	73580780	+	Silent	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr15:73580780A>G	uc002avm.3	+	24	3679	c.3537A>G	c.(3535-3537)CCA>CCG	p.P1179P	NEO1_uc010ukx.1_Silent_p.P1168P|NEO1_uc010uky.1_Silent_p.P1179P|NEO1_uc010ukz.1_Silent_p.P592P|NEO1_uc002avn.3_Silent_p.P817P	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor	1179	Cytoplasmic (Potential).				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						ATAAGTCTCCAGACCCAAACC	0.448												
ARNT2	9915	broad.mit.edu	37	15	80743280	80743280	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr15:80743280G>A	uc002bfr.2	+	2	257	c.91G>A	c.(91-93)GGA>AGA	p.G31R	ARNT2_uc002bfq.2_Missense_Mutation_p.G31R|ARNT2_uc010unm.1_Missense_Mutation_p.G20R|ARNT2_uc002bfs.2_Missense_Mutation_p.G20R	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	31					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			GGCGGCCACCGGACAGGTGAG	0.552												
ARNT2	9915	broad.mit.edu	37	15	80867400	80867400	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr15:80867400T>C	uc002bfr.2	+	14	1628	c.1462T>C	c.(1462-1464)TCC>CCC	p.S488P	ARNT2_uc010unm.1_Missense_Mutation_p.S477P|ARNT2_uc002bfs.2_Missense_Mutation_p.S477P	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	488					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			TGCAATCTTCTCCCAGGAAAG	0.468												
ZNF592	9640	broad.mit.edu	37	15	85328011	85328011	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr15:85328011A>G	uc002bld.2	+	4	2441	c.2105A>G	c.(2104-2106)GAC>GGC	p.D702G	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	702					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTCTACCCAGACCCTGTGAGG	0.582												
WDR24	84219	broad.mit.edu	37	16	737013	737013	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr16:737013C>T	uc002ciz.1	-	3	1823	c.1063G>A	c.(1063-1065)GCC>ACC	p.A355T	JMJD8_uc002ciw.1_5'Flank|JMJD8_uc002cix.1_5'Flank|JMJD8_uc002ciy.1_5'Flank	NM_032259	NP_115635	Q96S15	WDR24_HUMAN	WD repeat domain 24	485										ovary(1)|central_nervous_system(1)	2		Hepatocellular(780;0.0218)				CTCTCCTTGGCGGCGAAGGCC	0.701												
IGFALS	3483	broad.mit.edu	37	16	1841347	1841347	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr16:1841347A>C	uc002cmy.2	-	2	1153	c.1072T>G	c.(1072-1074)TTC>GTC	p.F358V	IGFALS_uc010uvn.1_Missense_Mutation_p.F396V|IGFALS_uc010uvo.1_5'UTR	NM_004970	NP_004961	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid	358	LRR 12.				cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding				0						AGGCCGAGGAAAGCGCCCGCC	0.652												
ZNF598	90850	broad.mit.edu	37	16	2052383	2052383	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr16:2052383A>C	uc002cof.1	-	7	734	c.719T>G	c.(718-720)TTT>TGT	p.F240C	ZNF598_uc002coe.1_5'UTR	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	240						intracellular	zinc ion binding			lung(1)|breast(1)	2						CTCACACAGAAAGTGCTTCTC	0.657												
SEPT12	124404	broad.mit.edu	37	16	4835891	4835891	+	Splice_Site	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr16:4835891T>G	uc002cxq.2	-	4	434	c.293_splice	c.e4-1	p.V98_splice	SEPT12_uc002cxr.2_Splice_Site_p.V98_splice|SEPT12_uc010bty.2_Splice_Site|uc002cxt.2_5'Flank	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2						cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			skin(1)	1						CCTCTATGACTGTGGAGGGAG	0.458												
SNX29	92017	broad.mit.edu	37	16	12571649	12571649	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr16:12571649A>C	uc002dby.3	+	12	1012	c.956A>C	c.(955-957)AAG>ACG	p.K319T		NM_001080530	NP_001073999	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	319	PX.				cell communication		phosphatidylinositol binding			ovary(1)	1						TTGCACCACAAGTTACAAAAC	0.453												
MYH11	4629	broad.mit.edu	37	16	15818135	15818135	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr16:15818135A>C	uc002ddy.2	-	31	4355	c.4248T>G	c.(4246-4248)GAT>GAG	p.D1416E	MYH11_uc002ddv.2_Missense_Mutation_p.D1423E|MYH11_uc002ddw.2_Missense_Mutation_p.D1416E|MYH11_uc002ddx.2_Missense_Mutation_p.D1423E|MYH11_uc010bvg.2_Missense_Mutation_p.D1248E|NDE1_uc010uzy.1_3'UTR|NDE1_uc002dds.2_3'UTR|MYH11_uc010bvh.2_Missense_Mutation_p.D122E|NDE1_uc002ddz.1_RNA	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1416	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						TTTCCAGTTTATCATAAGCGG	0.537			T	CBFB	AML							
ABCC12	94160	broad.mit.edu	37	16	48173097	48173097	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr16:48173097A>G	uc002efc.1	-	5	1154	c.808T>C	c.(808-810)TAT>CAT	p.Y270H	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Missense_Mutation_p.Y270H|ABCC12_uc010vgj.1_Splice_Site	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	270	ABC transmembrane type-1 1.|Helical; (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				AATATGACATACACTGATATC	0.488												
NUP93	9688	broad.mit.edu	37	16	56857749	56857749	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr16:56857749T>G	uc002eka.2	+	8	906	c.785T>G	c.(784-786)CTT>CGT	p.L262R	NUP93_uc002ekb.2_Missense_Mutation_p.L139R|NUP93_uc010vhi.1_Missense_Mutation_p.L139R	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	262					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						TTGGCGTACCTTGAGCAGAGG	0.542												
NFATC3	4775	broad.mit.edu	37	16	68224974	68224974	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr16:68224974C>T	uc002evo.1	+	9	2612	c.2402C>T	c.(2401-2403)TCC>TTC	p.S801F	NFATC3_uc010vkl.1_Missense_Mutation_p.S322F|NFATC3_uc010vkm.1_Missense_Mutation_p.S322F|NFATC3_uc010vkn.1_Missense_Mutation_p.S322F|NFATC3_uc010vko.1_Missense_Mutation_p.S322F|NFATC3_uc010vkp.1_Missense_Mutation_p.S322F|NFATC3_uc010vkq.1_Missense_Mutation_p.S322F|NFATC3_uc002evl.2_Missense_Mutation_p.S322F|NFATC3_uc002evk.2_Missense_Mutation_p.S801F|NFATC3_uc002evm.1_Missense_Mutation_p.S801F|NFATC3_uc002evn.1_Missense_Mutation_p.S801F|NFATC3_uc010vkr.1_Missense_Mutation_p.S322F|NFATC3_uc010vks.1_Missense_Mutation_p.S322F|NFATC3_uc010vkt.1_Missense_Mutation_p.S322F|NFATC3_uc010vku.1_Missense_Mutation_p.S322F|NFATC3_uc010vkv.1_Missense_Mutation_p.S322F|NFATC3_uc010vkw.1_Missense_Mutation_p.S322F|NFATC3_uc010vkx.1_Missense_Mutation_p.S322F|NFATC3_uc010vky.1_Missense_Mutation_p.S322F|NFATC3_uc010vkz.1_Missense_Mutation_p.S322F|NFATC3_uc010vla.1_Missense_Mutation_p.S322F|NFATC3_uc010vlb.1_Missense_Mutation_p.S322F|NFATC3_uc010vlc.1_Missense_Mutation_p.S322F	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	801					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		GTGGGGTCTTCCTATCAGCCT	0.413												
ZFP1	162239	broad.mit.edu	37	16	75203884	75203884	+	Silent	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr16:75203884A>G	uc002fdo.2	+	4	1040	c.876A>G	c.(874-876)GGA>GGG	p.G292G	ZFP1_uc002fdp.2_Silent_p.G237G|ZFP1_uc010cgt.2_Silent_p.G259G|ZFP1_uc010cgs.2_Silent_p.G237G|ZFP1_uc002fdq.2_Silent_p.G292G	NM_153688	NP_710155	Q6P2D0	ZFP1_HUMAN	zinc finger protein 1 homolog	292					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						TTCATACAGGAGAGCGACCCT	0.428												
LRRC50	123872	broad.mit.edu	37	16	84189352	84189352	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr16:84189352T>G	uc002fhl.3	+	5	920	c.739T>G	c.(739-741)TTG>GTG	p.L247V	LRRC50_uc010chi.1_RNA	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	247					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						CATGCCCGATTTGGTAaaaaa	0.348									Kartagener_syndrome			
METT10D	79066	broad.mit.edu	37	17	2323552	2323552	+	Silent	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr17:2323552C>T	uc002fut.2	-	10	1549	c.1401G>A	c.(1399-1401)AGG>AGA	p.R467R	METT10D_uc002fuu.3_RNA|METT10D_uc010cka.2_RNA|METT10D_uc002fuv.2_Intron|METT10D_uc010vqx.1_RNA|METT10D_uc010vqy.1_Silent_p.R249R	NM_024086	NP_076991	Q86W50	MET16_HUMAN	methyltransferase 10 domain containing	467							methyltransferase activity				0						TTTCCTCACTCCTTTCATCCT	0.627												
GP1BA	2811	broad.mit.edu	37	17	4835939	4835939	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr17:4835939T>G	uc010vsq.1	+	2	115	c.40T>G	c.(40-42)TTA>GTA	p.L14V	uc002fzn.1_RNA	NM_000173	NP_000164	P07359	GP1BA_HUMAN	platelet glycoprotein Ib alpha polypeptide	14											0						GCCAAGCCCCTTACACCCCCA	0.607												
EIF4A1	1973	broad.mit.edu	37	17	7476162	7476162	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr17:7476162G>A	uc002gho.1	+	9	1328	c.3G>A	c.(1-3)ATG>ATA	p.M1I	EIF4A1_uc002ghr.1_Missense_Mutation_p.M1I|EIF4A1_uc002ghq.1_Missense_Mutation_p.M1I|EIF4A1_uc002ghp.1_Missense_Mutation_p.M1I|SNORA48_uc002ghs.1_5'Flank	NM_001416	NP_001407	P60842	IF4A1_HUMAN	eukaryotic translation initiation factor 4A	1					nuclear-transcribed mRNA poly(A) tail shortening	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA cap binding|translation initiation factor activity			ovary(1)	1						TAAGGATCATGTCTGCGAGCC	0.622												
MYH8	4626	broad.mit.edu	37	17	10322320	10322320	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr17:10322320A>C	uc002gmm.2	-	4	333	c.238T>G	c.(238-240)TTC>GTC	p.F80V	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	80	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TTCATAGGGAAGACTTGGTCT	0.368									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling			
SKAP1	8631	broad.mit.edu	37	17	46262125	46262125	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr17:46262125G>A	uc002ini.1	-	7	639	c.527C>T	c.(526-528)TCC>TTC	p.S176F	SKAP1_uc002inj.1_Missense_Mutation_p.S176F|SKAP1_uc010dbd.1_Missense_Mutation_p.S82F|SKAP1_uc010dbe.1_Missense_Mutation_p.S176F	NM_003726	NP_003717	Q86WV1	SKAP1_HUMAN	src kinase associated phosphoprotein 1 isoform	176	PH.				positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding				0						TTCAAAGCAGGATTCTTTCTT	0.522												
FTSJ3	117246	broad.mit.edu	37	17	61897524	61897524	+	Silent	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr17:61897524T>G	uc002jbz.2	-	19	2344	c.2266A>C	c.(2266-2268)AGG>CGG	p.R756R	FTSJ3_uc002jca.2_Silent_p.R756R	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	756					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						TGCTCCAGCCTCTTCAGCATC	0.572												
SLC16A6	9120	broad.mit.edu	37	17	66267274	66267274	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr17:66267274C>T	uc002jgz.1	-	5	1215	c.1027G>A	c.(1027-1029)GGA>AGA	p.G343R	ARSG_uc002jhc.2_Intron|SLC16A6_uc002jha.1_Missense_Mutation_p.G343R	NM_004694	NP_004685	O15403	MOT7_HUMAN	solute carrier family 16, member 6	343	Helical; (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity				0	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	CCGATCCTTCCGAAAACTTCT	0.468												
COLEC12	81035	broad.mit.edu	37	18	480739	480739	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr18:480739T>A	uc002kkm.2	-	2	241	c.26A>T	c.(25-27)GAG>GTG	p.E9V		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	9	Cytoplasmic (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				TTGCACCTCCTCCTCCTCTGC	0.542												
HRH4	59340	broad.mit.edu	37	18	22040828	22040828	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr18:22040828C>T	uc002kvi.2	+	1	236	c.136C>T	c.(136-138)CTT>TTT	p.L46F	HRH4_uc010xbd.1_Missense_Mutation_p.L46F|HRH4_uc010dlx.2_Missense_Mutation_p.L46F	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	46	Cytoplasmic (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	GGACAAAAACCTTAGACATCG	0.333												
SMAD4	4089	broad.mit.edu	37	18	48604747	48604748	+	Missense_Mutation	DNP	CT	CT	TA			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr18:48604747_48604748CT>TA	uc010xdp.1	+	12	2107_2108	c.1569_1570CT>TA	c.(1567-1572)TGCTGG>TGTAGG	p.W524R	SMAD4_uc002lfb.3_Missense_Mutation_p.W369R	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	524	MH2.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.C523W(2)|p.?(2)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		AAACACCTTGCTGGATTGAAAT	0.48									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia			
TLE2	7089	broad.mit.edu	37	19	3005565	3005565	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:3005565G>A	uc002lww.2	-	17	2029	c.1766C>T	c.(1765-1767)ACG>ATG	p.T589M	TLE2_uc010xhb.1_Missense_Mutation_p.T256M|TLE2_uc010dth.2_Missense_Mutation_p.T590M|TLE2_uc010xhc.1_Missense_Mutation_p.T467M|TLE2_uc010dti.2_Missense_Mutation_p.T603M	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	589	WD 4.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGCCGTCCGTGTGGCCCTG	0.662												
TBXA2R	6915	broad.mit.edu	37	19	3600235	3600235	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:3600235C>T	uc002lyg.1	-	2	612	c.398G>A	c.(397-399)GGT>GAT	p.G133D	TBXA2R_uc002lye.1_Intron	NM_001060	NP_001051	P21731	TA2R_HUMAN	thromboxane A2 receptor isoform alpha	133	Cytoplasmic (Potential).				platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)	CCGGGTGATACCCAGGTAGCG	0.736												
CCDC94	55702	broad.mit.edu	37	19	4249309	4249309	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:4249309G>A	uc002lzv.3	+	2	142	c.109G>A	c.(109-111)GCC>ACC	p.A37T		NM_018074	NP_060544	Q9BW85	CCD94_HUMAN	coiled-coil domain containing 94	37											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0348)|STAD - Stomach adenocarcinoma(1328;0.183)		GCGGCTGATGGCCCCCTTCAA	0.602												
ELAVL1	1994	broad.mit.edu	37	19	8056617	8056617	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:8056617G>A	uc002mjb.2	-	2	250	c.83C>T	c.(82-84)CCT>CTT	p.P28L		NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1	28	RRM 1.				3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0						CATGTTCTGAGGGAGGTAGTT	0.428												
ZNF441	126068	broad.mit.edu	37	19	11891663	11891663	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:11891663G>A	uc010dyj.2	+	4	1218	c.1024G>A	c.(1024-1026)GGG>AGG	p.G342R	ZNF441_uc002msn.3_Missense_Mutation_p.G298R	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	342	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TAAGTATTGTGGGAAAGCATT	0.403												
RTBDN	83546	broad.mit.edu	37	19	12940627	12940627	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:12940627G>T	uc002mvi.2	-	2	297	c.167C>A	c.(166-168)GCA>GAA	p.A56E	RTBDN_uc002mvh.1_Missense_Mutation_p.A88E|RTBDN_uc002mvj.2_Missense_Mutation_p.A88E	NM_001080997	NP_001074466	Q9BSG5	RTBDN_HUMAN	retbindin isoform 1	56						extracellular region					0						GTGCTCACCTGCCAGGTGCAG	0.587												
FAM129C	199786	broad.mit.edu	37	19	17664149	17664149	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:17664149T>C	uc010xpr.1	+	16	2009	c.1871T>C	c.(1870-1872)TTC>TCC	p.F624S	GLT25D1_uc002nhc.1_5'Flank	NM_173544	NP_775815	Q86XR2	NIBL2_HUMAN	B-cell novel protein 1 isoform a	624											0						GTGTCAAGTTTCCTGGCTGGG	0.463												
ZNF486	90649	broad.mit.edu	37	19	20295165	20295165	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:20295165G>A	uc002nou.2	+	2	88	c.31G>A	c.(31-33)GAA>AAA	p.E11K		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	11					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGTTTTTCAGGAATCATTGCA	0.393												
ZNF208	7757	broad.mit.edu	37	19	22157177	22157177	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:22157177T>C	uc002nqp.2	-	4	808	c.659A>G	c.(658-660)AAG>AGG	p.K220R	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATGAGCACTCTTATAATAAGT	0.358												
ZNF676	163223	broad.mit.edu	37	19	22362948	22362948	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:22362948T>G	uc002nqs.1	-	3	1889	c.1571A>C	c.(1570-1572)AAG>ACG	p.K524T		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	524	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				ATGAATTATCTTATGTTCAGT	0.398												
CD22	933	broad.mit.edu	37	19	35832422	35832422	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:35832422T>A	uc010edt.2	+	8	1761	c.1684T>A	c.(1684-1686)TCC>ACC	p.S562T	CD22_uc010xst.1_Missense_Mutation_p.S390T|CD22_uc010edu.2_Missense_Mutation_p.S474T|CD22_uc010edv.2_Missense_Mutation_p.S562T|CD22_uc002nzb.3_Missense_Mutation_p.S385T|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	562	Extracellular (Potential).|Ig-like C2-type 5.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	TGACTCCATCTCCCCAGAAGA	0.522												
APLP1	333	broad.mit.edu	37	19	36369820	36369820	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:36369820C>A	uc002oce.2	+	15	1814	c.1676C>A	c.(1675-1677)CCT>CAT	p.P559H	APLP1_uc010xsz.1_Missense_Mutation_p.P520H|APLP1_uc002ocf.2_Missense_Mutation_p.P560H|APLP1_uc002ocg.2_Missense_Mutation_p.P463H|APLP1_uc010xta.1_Missense_Mutation_p.P553H	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	559	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGGGGTTTCCCTTTCCACTCA	0.587												
TYROBP	7305	broad.mit.edu	37	19	36398163	36398163	+	Missense_Mutation	SNP	G	G	A	rs150310136		TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:36398163G>A	uc002ocm.2	-	4	289	c.233C>T	c.(232-234)GCG>GTG	p.A78V	TYROBP_uc002ocn.2_Missense_Mutation_p.A77V	NM_003332	NP_003323	O43914	TYOBP_HUMAN	TYRO protein tyrosine kinase binding protein	78	Cytoplasmic (Potential).				axon guidance|cell junction assembly|cellular defense response|intracellular signal transduction|regulation of immune response	integral to plasma membrane|intracellular	identical protein binding|receptor signaling protein activity				0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TTTCCGGGTCGCTGCTGGAGG	0.537												
ZNF566	84924	broad.mit.edu	37	19	36940481	36940481	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:36940481T>C	uc002oea.3	-	5	737	c.655A>G	c.(655-657)AAA>GAA	p.K219E	ZNF566_uc010xte.1_Missense_Mutation_p.K219E|ZNF566_uc010xtf.1_Missense_Mutation_p.K220E|ZNF566_uc002oeb.3_Missense_Mutation_p.K219E|ZNF566_uc002oec.3_Missense_Mutation_p.K115E|ZNF566_uc010xtg.1_Missense_Mutation_p.K115E	NM_032838	NP_116227	Q969W8	ZN566_HUMAN	zinc finger protein 566 isoform 1	219	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					GTATGAATTTTCTGATGATGA	0.388												
SNRPA	6626	broad.mit.edu	37	19	41263270	41263270	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:41263270A>G	uc002ooz.2	+	2	642	c.107A>G	c.(106-108)CAG>CGG	p.Q36R	SNRPA_uc002opa.2_5'UTR	NM_004596	NP_004587	P09012	SNRPA_HUMAN	small nuclear ribonucleoprotein polypeptide A	36	RRM 1.					nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding			skin(2)|ovary(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			ATCTTCTCCCAGTTTGGCCAG	0.527												
PSG6	5675	broad.mit.edu	37	19	43528974	43528974	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:43528974G>T	uc002ovh.1	-	2	406	c.317C>A	c.(316-318)ACA>AAA	p.T106K	PSG11_uc002ouw.2_Missense_Mutation_p.T106K|PSG10_uc002ouv.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.T106K|PSG11_uc002ovm.1_Missense_Mutation_p.T100K|PSG11_uc002ovn.1_Missense_Mutation_p.T106K|PSG11_uc002ovo.1_Intron|PSG11_uc002ovp.1_Intron			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	99	Ig-like V-type.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				GGAATATACTGTTTCTCGTCC	0.453												
SLC6A16	28968	broad.mit.edu	37	19	49813671	49813671	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:49813671C>A	uc002pmz.2	-	3	746	c.512G>T	c.(511-513)GGC>GTC	p.G171V	SLC6A16_uc002pna.2_Missense_Mutation_p.G171V|hsa-mir-4324|MI0015854_5'Flank	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	171						integral to membrane|intracellular	neurotransmitter:sodium symporter activity			skin(2)|ovary(1)|kidney(1)	4		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		TACACCCATGCCACCCTGACG	0.557												
KCNC3	3748	broad.mit.edu	37	19	50826555	50826555	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:50826555T>G	uc002pru.1	-	2	1950	c.1655A>C	c.(1654-1656)AAG>ACG	p.K552T	KCNC3_uc002prt.1_Missense_Mutation_p.K188T	NM_004977	NP_004968	Q14003	KCNC3_HUMAN	Shaw-related voltage-gated potassium channel	552	Cytoplasmic (Potential).				cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		CAGCTTCTGCTTGGCCATGGC	0.647												
ZNF331	55422	broad.mit.edu	37	19	54080139	54080139	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:54080139A>G	uc002qbx.1	+	7	1759	c.325A>G	c.(325-327)AAA>GAA	p.K109E	ZNF331_uc002qby.1_Missense_Mutation_p.K109E|ZNF331_uc002qbz.1_Missense_Mutation_p.K109E|ZNF331_uc002qca.1_Missense_Mutation_p.K109E|ZNF331_uc010eqr.1_Missense_Mutation_p.K109E|ZNF331_uc002qcb.1_Missense_Mutation_p.K109E|ZNF331_uc002qcc.1_Missense_Mutation_p.K109E|ZNF331_uc002qcd.1_Missense_Mutation_p.K109E	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		CAATTATGTCAAAAGACCTGC	0.453			T	?	follicular thyroid adenoma							
KIR3DL1	3811	broad.mit.edu	37	19	55331283	55331283	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:55331283A>C	uc002qhk.3	+	4	534	c.471A>C	c.(469-471)AAA>AAC	p.K157N	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.K99N|KIR3DL1_uc010esf.2_Missense_Mutation_p.K62N|KIR3DL1_uc010yfo.1_Missense_Mutation_p.K99N|KIR3DL1_uc002qhl.3_Missense_Mutation_p.K157N	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	157	Extracellular (Potential).|Ig-like C2-type 2.				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		TTCTGCACAAAGAGGGGATCT	0.537												
PTPRH	5794	broad.mit.edu	37	19	55708037	55708037	+	Missense_Mutation	SNP	G	G	A	rs73619559	byFrequency	TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:55708037G>A	uc002qjq.2	-	10	2183	c.2110C>T	c.(2110-2112)CGG>TGG	p.R704W	PTPRH_uc010esv.2_Missense_Mutation_p.R526W|PTPRH_uc002qjs.2_Missense_Mutation_p.R711W	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	704	Extracellular (Potential).|Fibronectin type-III 8.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TGGGAGCCCCGCTGTCCTCCC	0.627												
ZNF551	90233	broad.mit.edu	37	19	58198809	58198809	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:58198809G>A	uc002qpw.3	+	3	1341	c.1118G>A	c.(1117-1119)AGG>AAG	p.R373K	ZNF551_uc002qpv.3_Missense_Mutation_p.R316K|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	389					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TCTGGAGAAAGGCCTTATCAG	0.448												
TMEM178	130733	broad.mit.edu	37	2	39944200	39944200	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr2:39944200G>A	uc002rrt.2	+	4	728	c.703G>A	c.(703-705)GAT>AAT	p.D235N	TMEM178_uc010fam.1_Missense_Mutation_p.D189N	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor	235	Extracellular (Potential).					integral to membrane					0		all_hematologic(82;0.248)				TATCTCGTATGATTTGAACCG	0.418												
SOCS5	9655	broad.mit.edu	37	2	46986595	46986595	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr2:46986595A>G	uc002rvf.2	+	2	1090	c.926A>G	c.(925-927)GAA>GGA	p.E309G	SOCS5_uc010yoe.1_Missense_Mutation_p.E278G|SOCS5_uc002rvg.2_Missense_Mutation_p.E309G	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	309					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			GGAATGACTGAAATAAGTGGG	0.453												
ERLEC1	27248	broad.mit.edu	37	2	54014465	54014465	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr2:54014465G>A	uc002rxl.2	+	1	398	c.118G>A	c.(118-120)GAC>AAC	p.D40N	ASB3_uc002rxg.1_5'Flank|ASB3_uc002rxh.1_5'Flank|ASB3_uc002rxi.3_Intron|ASB3_uc010yoo.1_5'Flank|ERLEC1_uc002rxm.2_Missense_Mutation_p.D40N|ERLEC1_uc002rxn.2_Missense_Mutation_p.D40N	NM_015701	NP_056516	Q96DZ1	ERLEC_HUMAN	erlectin isoform 1	40					ER-associated protein catabolic process	endoplasmic reticulum lumen	glycoprotein binding|protein binding			ovary(2)	2						ACTCAGCGATGACATCCCTTT	0.672												
EFEMP1	2202	broad.mit.edu	37	2	56144910	56144910	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr2:56144910T>G	uc002rzh.2	-	4	737	c.407A>C	c.(406-408)AAC>ACC	p.N136T	EFEMP1_uc002rzi.2_Missense_Mutation_p.N136T|EFEMP1_uc002rzj.2_Missense_Mutation_p.N136T|EFEMP1_uc010ypc.1_Missense_Mutation_p.N78T	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	136					negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GATGACAAAGTTATTTCGGCC	0.592												
RAB11FIP5	26056	broad.mit.edu	37	2	73303283	73303283	+	Silent	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr2:73303283G>A	uc002siu.3	-	4	1837	c.1596C>T	c.(1594-1596)GCC>GCT	p.A532A	RAB11FIP5_uc002sis.3_5'UTR|RAB11FIP5_uc002sit.3_Silent_p.A454A	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	532					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						CCACAGGGGCGGCACTGAGGG	0.607												
PROM2	150696	broad.mit.edu	37	2	95947106	95947106	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr2:95947106T>C	uc002suh.1	+	12	1677	c.1544T>C	c.(1543-1545)CTC>CCC	p.L515P	PROM2_uc002sui.2_Missense_Mutation_p.L515P|PROM2_uc002suj.2_Missense_Mutation_p.L169P|PROM2_uc002suk.2_Missense_Mutation_p.L515P|PROM2_uc002sul.2_Missense_Mutation_p.L41P|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	515	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						AACGGCGAGCTCTTTGAGGTA	0.642												
SLC9A2	6549	broad.mit.edu	37	2	103318883	103318883	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr2:103318883A>C	uc002tca.2	+	9	1909	c.1767A>C	c.(1765-1767)AAA>AAC	p.K589N		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	589	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						GTGAAGAAAAAATAAGGAAGG	0.303												
RANBP2	5903	broad.mit.edu	37	2	109383177	109383177	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr2:109383177A>T	uc002tem.3	+	20	6308	c.6182A>T	c.(6181-6183)AAA>ATA	p.K2061I		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2061	RanBD1 2.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						GGGAACTTAAAAATTCTCAAA	0.388												
MERTK	10461	broad.mit.edu	37	2	112786254	112786254	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr2:112786254G>A	uc002thk.1	+	19	2935	c.2813G>A	c.(2812-2814)TGG>TAG	p.W938*	MERTK_uc002thl.1_Nonsense_Mutation_p.W762*	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	938	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						AGTGAGGAATGGGAAGATCTG	0.542												
TUBA3D	113457	broad.mit.edu	37	2	132240409	132240409	+	Silent	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr2:132240409C>T	uc002tsu.3	+	5	1448	c.1341C>T	c.(1339-1341)GGC>GGT	p.G447G		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	447					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		CTGAAGAAGGCGAAGAATACT	0.547												
CSRNP3	80034	broad.mit.edu	37	2	166535277	166535277	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr2:166535277G>T	uc002udf.2	+	7	1148	c.772G>T	c.(772-774)GAA>TAA	p.E258*	CSRNP3_uc002udg.2_Nonsense_Mutation_p.E258*	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	258					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						AGGTAGAATTGAATTTAATCC	0.443												
TTN	7273	broad.mit.edu	37	2	179429558	179429558	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr2:179429558C>T	uc010zfg.1	-	275	73821	c.73597G>A	c.(73597-73599)GGC>AGC	p.G24533S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G18228S|TTN_uc010zfi.1_Missense_Mutation_p.G18161S|TTN_uc010zfj.1_Missense_Mutation_p.G18036S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25460							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTTGGTGCCTCCATCATTC	0.393												
FAM171B	165215	broad.mit.edu	37	2	187627498	187627498	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr2:187627498A>G	uc002ups.2	+	8	2541	c.2429A>G	c.(2428-2430)AAG>AGG	p.K810R	FAM171B_uc002upr.1_Missense_Mutation_p.K777R|FAM171B_uc002upt.2_Missense_Mutation_p.K279R	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	810	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						AGAGATAGCAAGACTAACATC	0.458												
ERGIC3	51614	broad.mit.edu	37	20	34136347	34136347	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr20:34136347C>T	uc002xct.2	+	6	616	c.547C>T	c.(547-549)CGG>TGG	p.R183W	ERGIC3_uc002xcr.1_Missense_Mutation_p.R183W|ERGIC3_uc010zvg.1_Missense_Mutation_p.R183W|ERGIC3_uc002xcs.2_Missense_Mutation_p.R183W|ERGIC3_uc002xcu.2_Missense_Mutation_p.R183W|ERGIC3_uc002xcv.2_Missense_Mutation_p.R146W	NM_015966	NP_057050	Q9Y282	ERGI3_HUMAN	serologically defined breast cancer antigen 84	183	Lumenal (Potential).				vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane	protein binding			large_intestine(2)|ovary(1)	3	Lung NSC(9;0.00489)|all_lung(11;0.00729)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			TGAGCAGTGCCGGCGAGAGGG	0.542												
ZNF831	128611	broad.mit.edu	37	20	57829765	57829765	+	Silent	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr20:57829765C>T	uc002yan.2	+	5	5001	c.5001C>T	c.(4999-5001)AGC>AGT	p.S1667S		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1667						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					ACACCAGCAGCGACGATGAAG	0.438												
ABCG1	9619	broad.mit.edu	37	21	43714709	43714709	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr21:43714709T>G	uc002zaq.2	+	14	1853	c.1747T>G	c.(1747-1749)TTC>GTC	p.F583V	ABCG1_uc002zan.2_Missense_Mutation_p.F573V|ABCG1_uc002zam.2_Missense_Mutation_p.F549V|ABCG1_uc002zao.2_Missense_Mutation_p.F568V|ABCG1_uc002zap.2_Missense_Mutation_p.F571V|ABCG1_uc002zar.2_Missense_Mutation_p.F582V|ABCG1_uc011aev.1_Missense_Mutation_p.F594V|ABCG1_uc010gpb.1_Missense_Mutation_p.L223R	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	583	ABC transmembrane type-2.|Helical; (Potential).				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	CTCGGGGTTCTTCGTCAGCTT	0.617												
ZNF280B	140883	broad.mit.edu	37	22	22842771	22842771	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr22:22842771T>G	uc002zwc.1	-	4	1729	c.953A>C	c.(952-954)AAT>ACT	p.N318T	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	318					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AAACTTAACATTTTTTAGAAC	0.463												
SEZ6L	23544	broad.mit.edu	37	22	26692998	26692998	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr22:26692998C>T	uc003acb.2	+	4	1270	c.1114C>T	c.(1114-1116)CGG>TGG	p.R372W	SEZ6L_uc003acc.2_Missense_Mutation_p.R372W|SEZ6L_uc011akc.1_Missense_Mutation_p.R372W|SEZ6L_uc003acd.2_Missense_Mutation_p.R372W|SEZ6L_uc011akd.1_Missense_Mutation_p.R372W|SEZ6L_uc003ace.2_Missense_Mutation_p.R372W|SEZ6L_uc003acf.1_Missense_Mutation_p.R145W|SEZ6L_uc010gvc.1_Missense_Mutation_p.R145W	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	372	CUB 1.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CGTCTACTTCCGGACCTTCCA	0.612												
NEFH	4744	broad.mit.edu	37	22	29884869	29884869	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr22:29884869G>A	uc003afo.2	+	4	1311	c.1240G>A	c.(1240-1242)GGC>AGC	p.G414S	NEFH_uc003afp.2_5'Flank	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	414	Tail.				cell death|nervous system development	neurofilament					0						GTGTCGGATTGGCTTTGGCCC	0.408												
MTMR3	8897	broad.mit.edu	37	22	30421750	30421750	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr22:30421750A>G	uc003agv.3	+	20	3885	c.3557A>G	c.(3556-3558)GAC>GGC	p.D1186G	MTMR3_uc003agu.3_Missense_Mutation_p.D1158G|MTMR3_uc003agw.3_Missense_Mutation_p.D1149G	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	1186					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TCCAGCATTGACCTTGAACTG	0.532												
SLC6A11	6538	broad.mit.edu	37	3	10975851	10975851	+	Missense_Mutation	SNP	C	C	T	rs61730121	byFrequency	TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr3:10975851C>T	uc003bvz.2	+	12	1608	c.1574C>T	c.(1573-1575)GCG>GTG	p.A525V		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	525	Helical; Name=11; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		GGGATCTGCGCGGTAAGGGCC	0.592												
ANKRD28	23243	broad.mit.edu	37	3	15778572	15778572	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr3:15778572A>T	uc003caj.1	-	5	573	c.430T>A	c.(430-432)TTA>ATA	p.L144I	ANKRD28_uc003cai.1_5'UTR|ANKRD28_uc011avz.1_5'UTR|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.L174I|ANKRD28_uc003cam.2_Missense_Mutation_p.L177I	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	144	ANK 4.					nucleoplasm	protein binding			breast(1)	1						GCATGATGTAATGCAGTCCTC	0.423												
ZNF167	55888	broad.mit.edu	37	3	44611431	44611431	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr3:44611431A>G	uc010hin.2	+	6	1217	c.829A>G	c.(829-831)AAG>GAG	p.K277E	ZNF167_uc003cnh.2_RNA|ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Missense_Mutation_p.K126E|ZNF167_uc003cnj.2_Missense_Mutation_p.K277E|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	277	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		GAACATGATGAAGGGTTCAGA	0.428												
CDCP1	64866	broad.mit.edu	37	3	45153868	45153868	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr3:45153868A>C	uc003com.2	-	3	497	c.362T>G	c.(361-363)CTC>CGC	p.L121R	CDCP1_uc003con.2_Missense_Mutation_p.L121R	NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	121	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		AGTTCTGTTGAGGGTAGGCAA	0.502												
SCAP	22937	broad.mit.edu	37	3	47456465	47456465	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr3:47456465C>A	uc003crh.1	-	20	3413	c.3158G>T	c.(3157-3159)AGT>ATT	p.S1053I	SCAP_uc011baz.1_Missense_Mutation_p.S797I|SCAP_uc003crg.2_Missense_Mutation_p.S660I|uc003cri.2_RNA	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	1053	Interaction with SREBF2 (By similarity).|Cytoplasmic (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		GGCAGGGGAACTGCCCCGCCC	0.592												
RHOA	387	broad.mit.edu	37	3	49413010	49413010	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr3:49413010G>A	uc003cwu.2	-	2	289	c.13C>T	c.(13-15)CGG>TGG	p.R5W	RHOA_uc010hku.2_Intron	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	5					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	AGTTTCTTCCGGATGGCAGCC	0.473												
CACNA2D3	55799	broad.mit.edu	37	3	55038842	55038842	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr3:55038842G>A	uc003dhf.2	+	32	2791	c.2743G>A	c.(2743-2745)GAT>AAT	p.D915N	CACNA2D3_uc003dhg.1_Missense_Mutation_p.D821N|CACNA2D3_uc003dhh.1_RNA	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	915	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GGAAAGCAGCGATGGCGCCCA	0.458												
BBX	56987	broad.mit.edu	37	3	107491699	107491699	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr3:107491699A>C	uc010hpr.2	+	11	1458	c.1131A>C	c.(1129-1131)CAA>CAC	p.Q377H	BBX_uc003dwk.3_Missense_Mutation_p.Q377H|BBX_uc003dwl.3_Intron|BBX_uc010hps.1_Missense_Mutation_p.Q398H|BBX_uc003dwm.3_Missense_Mutation_p.Q377H|BBX_uc003dwo.3_5'Flank	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	377					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			AGGCATTGCAAATAGATGACA	0.313												
GHSR	2693	broad.mit.edu	37	3	172162986	172162986	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr3:172162986A>G	uc003fib.1	-	2	1066	c.1066T>C	c.(1066-1068)TCT>CCT	p.S356P		NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	356	Cytoplasmic (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CAGGCCCGAGAACTTTCATCT	0.468												
PIK3CA	5290	broad.mit.edu	37	3	178917478	178917478	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr3:178917478G>A	uc003fjk.2	+	3	510	c.353G>A	c.(352-354)GGT>GAT	p.G118D		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	118					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G118D(6)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TTTATTAAAGGTTTTGCTATC	0.338		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)		
PIK3CA	5290	broad.mit.edu	37	3	178917669	178917669	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr3:178917669T>C	uc003fjk.2	+	3	701	c.544T>C	c.(544-546)TAT>CAT	p.Y182H		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	182	PI3K-RBD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AAAGCACATATATAATAAATT	0.313		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)		
D4S234E	27065	broad.mit.edu	37	4	4389469	4389469	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr4:4389469T>C	uc011bvz.1	+	5	1394	c.113T>C	c.(112-114)TTC>TCC	p.F38S	D4S234E_uc011bwa.1_Missense_Mutation_p.F38S|D4S234E_uc003ghz.2_Missense_Mutation_p.F38S|D4S234E_uc003gia.2_Missense_Mutation_p.F38S|D4S234E_uc003gib.2_Missense_Mutation_p.F38S	NM_014392	NP_055207	P42857	NSG1_HUMAN	brain neuron cytoplasmic protein 1	38	Cytoplasmic (Potential).				dopamine receptor signaling pathway	Golgi membrane|integral to membrane|nucleus	dopamine receptor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.166)		CAGCTGCAGTTCCCGCCCCCG	0.637												
SLC4A4	8671	broad.mit.edu	37	4	72316960	72316960	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr4:72316960G>A	uc003hfy.2	+	11	1381	c.1264G>A	c.(1264-1266)GAT>AAT	p.D422N	SLC4A4_uc010iic.2_Missense_Mutation_p.D422N|SLC4A4_uc010iib.2_Missense_Mutation_p.D422N|SLC4A4_uc003hfz.2_Missense_Mutation_p.D422N|SLC4A4_uc003hgc.3_Missense_Mutation_p.D378N|SLC4A4_uc010iid.2_5'UTR|SLC4A4_uc003hga.2_Missense_Mutation_p.D300N|SLC4A4_uc003hgb.3_Missense_Mutation_p.D378N	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	422	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TACGCCCCATGATGGAGGTCA	0.443												
CENPE	1062	broad.mit.edu	37	4	104030045	104030045	+	Silent	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr4:104030045A>C	uc003hxb.1	-	48	8016	c.7926T>G	c.(7924-7926)TCT>TCG	p.S2642S	CENPE_uc003hxc.1_Silent_p.S2521S	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	2642	Globular autoinhibitory domain (By similarity).				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		CAAAAAAACAAGATTTTGGTG	0.373												
NDST4	64579	broad.mit.edu	37	4	115998026	115998026	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr4:115998026T>G	uc003ibu.2	-	2	846	c.167A>C	c.(166-168)AAA>ACA	p.K56T	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	56	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TGGTAGAATTTTGATGTCAGT	0.413												
HSPA4L	22824	broad.mit.edu	37	4	128726362	128726362	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr4:128726362A>G	uc003ifm.2	+	9	1373	c.1120A>G	c.(1120-1122)AGA>GGA	p.R374G	HSPA4L_uc010iny.1_Missense_Mutation_p.R333G|HSPA4L_uc011cgr.1_Missense_Mutation_p.R341G	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	374					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						AGCTGTTGCAAGAGGATGTGC	0.343												
PCDH10	57575	broad.mit.edu	37	4	134072953	134072953	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr4:134072953C>T	uc003iha.2	+	1	2484	c.1658C>T	c.(1657-1659)GCG>GTG	p.A553V	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.A553V	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	553	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		AGCCCCCAGGCGCTGGCTGGT	0.602												
TRIM2	23321	broad.mit.edu	37	4	154216607	154216607	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr4:154216607A>G	uc003ing.2	+	6	1049	c.848A>G	c.(847-849)GAG>GGG	p.E283G	TRIM2_uc003inh.2_Missense_Mutation_p.E310G	NM_001130067	NP_001123539	Q9C040	TRIM2_HUMAN	tripartite motif-containing 2 isoform 2	283						cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		AAGCTGAACGAGCTGGCCGAC	0.587												
GALNT7	51809	broad.mit.edu	37	4	174169235	174169235	+	Silent	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr4:174169235A>G	uc003isz.3	+	2	314	c.231A>G	c.(229-231)GGA>GGG	p.G77G		NM_017423	NP_059119	Q86SF2	GALT7_HUMAN	polypeptide N-acetylgalactosaminyltransferase 7	77	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)	1		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		ATGTTGAAGGAGTAGAAGTGG	0.483												
WWC2	80014	broad.mit.edu	37	4	184233538	184233538	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr4:184233538G>C	uc010irx.2	+	22	3611	c.3429G>C	c.(3427-3429)GAG>GAC	p.E1143D	WWC2_uc003ivk.3_Missense_Mutation_p.E938D|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_Missense_Mutation_p.E825D|WWC2_uc003ivn.3_Missense_Mutation_p.E658D|WWC2_uc010irz.2_Missense_Mutation_p.E484D|WWC2_uc003ivo.3_Missense_Mutation_p.E271D	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	1143	Potential.									ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		TGAATGCAGAGAAGTTGATGA	0.498												
RAI14	26064	broad.mit.edu	37	5	34811167	34811167	+	Silent	SNP	C	C	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr5:34811167C>A	uc003jir.2	+	8	697	c.501C>A	c.(499-501)ATC>ATA	p.I167I	RAI14_uc010iur.2_Silent_p.I167I|RAI14_uc011coj.1_Silent_p.I167I|RAI14_uc010ius.1_Silent_p.I96I|RAI14_uc003jis.2_Silent_p.I170I|RAI14_uc003jit.2_Silent_p.I167I|RAI14_uc011cok.1_Silent_p.I159I	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	167	ANK 5.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					ACAGTGAGATCTGTCACTTTC	0.428												
PCDHB5	26167	broad.mit.edu	37	5	140516596	140516596	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr5:140516596A>G	uc003liq.2	+	1	1797	c.1580A>G	c.(1579-1581)GAG>GGG	p.E527G		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	527	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGGCGTTCGAGTTCCGCGTG	0.687												
PCDHB15	56121	broad.mit.edu	37	5	140627353	140627353	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr5:140627353T>A	uc003lje.2	+	1	2207	c.2207T>A	c.(2206-2208)CTG>CAG	p.L736Q		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	736	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCAGGGCATCTGGTGGACGTG	0.612												
PCDHGA2	56113	broad.mit.edu	37	5	140719560	140719560	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr5:140719560A>C	uc003ljk.1	+	1	1207	c.1022A>C	c.(1021-1023)AAT>ACT	p.N341T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.N341T	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	341	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGATGTGAATGACAATGCC	0.423												
LSM11	134353	broad.mit.edu	37	5	157181043	157181043	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr5:157181043A>C	uc003lxe.1	+	3	624	c.620A>C	c.(619-621)AAA>ACA	p.K207T	LSM11_uc003lxf.1_5'Flank	NM_173491	NP_775762	P83369	LSM11_HUMAN	LSM11, U7 small nuclear RNA associated	207					histone mRNA 3'-end processing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	histone pre-mRNA 3'end processing complex|nucleoplasm|U7 snRNP	protein binding|U7 snRNA binding				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACCTACCGAAAACCTGTCCTA	0.433												
TUBB2B	347733	broad.mit.edu	37	6	3226489	3226489	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr6:3226489G>A	uc003mvg.2	-	3	372	c.181C>T	c.(181-183)CCT>TCT	p.P61S	uc003mvi.1_5'Flank|TUBB2B_uc010jnj.2_Intron|TUBB2B_uc010jnk.2_5'UTR|TUBB2B_uc003mvh.2_Silent_p.F35F	NM_178012	NP_821080	Q9BVA1	TBB2B_HUMAN	tubulin, beta 2B	61					'de novo' posttranslational protein folding|microtubule-based movement|neuron migration|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			large_intestine(1)	1	Ovarian(93;0.0386)	all_hematologic(90;0.108)				ATGGCCCGAGGAACATATTTG	0.532												
RANBP9	10048	broad.mit.edu	37	6	13644914	13644914	+	Silent	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr6:13644914G>A	uc003nbb.2	-	6	1034	c.975C>T	c.(973-975)GTC>GTT	p.V325V	RANBP9_uc003nba.2_5'UTR	NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	325	B30.2/SPRY.				axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			AATTGGCATCGACCACTTCTC	0.388												
GABBR1	2550	broad.mit.edu	37	6	29574733	29574733	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr6:29574733T>C	uc003nmt.3	-	18	2494	c.2158A>G	c.(2158-2160)ATG>GTG	p.M720V	GABBR1_uc003nmp.3_Missense_Mutation_p.M603V|GABBR1_uc003nms.3_Missense_Mutation_p.M603V|GABBR1_uc003nmu.3_Missense_Mutation_p.M658V|GABBR1_uc011dlr.1_Missense_Mutation_p.M543V	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	720	Helical; Name=4; (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	AGGACATCCATGCCCACCAGC	0.567												
HCRTR2	3062	broad.mit.edu	37	6	55145185	55145185	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr6:55145185C>T	uc003pcl.2	+	6	1363	c.1048C>T	c.(1048-1050)CAC>TAC	p.H350Y	HCRTR2_uc010jzv.2_RNA	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	350	Helical; Name=7; (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TACCTTTTCACACTGGCTTGT	0.378												
C6orf204	387119	broad.mit.edu	37	6	118804953	118804953	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr6:118804953T>G	uc003pxz.1	-	7	2094	c.1506A>C	c.(1504-1506)AAA>AAC	p.K502N	C6orf204_uc003pya.1_Missense_Mutation_p.K505N	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	502	Potential.					centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		TCTGCTTTTCTTTGTTTTGTT	0.353												
EYA4	2070	broad.mit.edu	37	6	133846387	133846387	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr6:133846387A>G	uc003qec.3	+	19	2292	c.1834A>G	c.(1834-1836)AAA>GAA	p.K612E	EYA4_uc011ecq.1_Intron|EYA4_uc011ecr.1_Intron|EYA4_uc003qed.3_Intron|EYA4_uc003qee.3_Missense_Mutation_p.K589E|EYA4_uc011ecs.1_Missense_Mutation_p.K618E|uc003qeg.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	612					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		ACAGGCAGCAAAAAAGGTAAC	0.398												
RSPH3	83861	broad.mit.edu	37	6	159420551	159420551	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr6:159420551C>T	uc003qrx.2	-	1	648	c.458G>A	c.(457-459)CGG>CAG	p.R153Q	RSPH3_uc010kju.2_Missense_Mutation_p.R153Q|RSPH3_uc003qry.1_Missense_Mutation_p.R153Q	NM_031924	NP_114130	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog	153										ovary(1)|skin(1)	2		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		GCTCGGGGCCCGAGAGGTGCG	0.662												
TTLL2	83887	broad.mit.edu	37	6	167754950	167754950	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr6:167754950T>C	uc003qvs.1	+	3	1650	c.1562T>C	c.(1561-1563)CTC>CCC	p.L521P	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	521					protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CACAAGACACTCATGCCCTAC	0.572												
OSBPL3	26031	broad.mit.edu	37	7	24905028	24905028	+	Silent	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr7:24905028A>G	uc003sxf.2	-	7	1011	c.606T>C	c.(604-606)TCT>TCC	p.S202S	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Silent_p.S202S|OSBPL3_uc003sxh.2_Silent_p.S202S|OSBPL3_uc003sxi.2_Silent_p.S202S	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	202					lipid transport		lipid binding|protein binding			skin(1)	1						CACCACCACAAGAAAATGATA	0.403												
DPY19L1	23333	broad.mit.edu	37	7	35057571	35057571	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr7:35057571T>G	uc003tem.3	-	3	260	c.115A>C	c.(115-117)ACA>CCA	p.T39P		NM_015283	NP_056098	Q2PZI1	D19L1_HUMAN	dpy-19-like 1	39						integral to membrane					0						AAGAGGTGTGTTATATGGCTC	0.323												
GLI3	2737	broad.mit.edu	37	7	42005274	42005274	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr7:42005274C>T	uc011kbh.1	-	15	3488	c.3397G>A	c.(3397-3399)GGG>AGG	p.G1133R	GLI3_uc011kbg.1_Missense_Mutation_p.G1074R	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1133					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						TCTGGCAGCCCGGGCGCGTCA	0.642									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome			
ZSCAN21	7589	broad.mit.edu	37	7	99655484	99655484	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr7:99655484A>C	uc003uso.2	+	3	707	c.563A>C	c.(562-564)GAG>GCG	p.E188A	ZSCAN21_uc003usn.1_Missense_Mutation_p.E187A	NM_145914	NP_666019	Q9Y5A6	ZSC21_HUMAN	zinc finger protein 38	188					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GAGGAGCAGGAGTTCGCTCAA	0.542												
STAG3	10734	broad.mit.edu	37	7	99808704	99808704	+	Silent	SNP	G	G	A	rs147288707		TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr7:99808704G>A	uc003utx.1	+	30	3464	c.3309G>A	c.(3307-3309)CCG>CCA	p.P1103P	STAG3_uc011kjk.1_Silent_p.P1045P|GATS_uc003uty.3_Intron|GATS_uc003utz.3_Intron|GATS_uc003uua.3_Intron|GATS_uc010lgt.2_Intron|STAG3_uc003uub.1_Silent_p.P327P	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	1103					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ACAGCATCCCGCCCACGCCCA	0.572												
MET	4233	broad.mit.edu	37	7	116397506	116397506	+	Silent	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr7:116397506T>G	uc003vij.2	+	7	2065	c.1878T>G	c.(1876-1878)GTT>GTG	p.V626V	MET_uc010lkh.2_Silent_p.V626V|MET_uc011knd.1_Silent_p.V626V|MET_uc011kne.1_Silent_p.V598V|MET_uc011knf.1_Silent_p.V626V|MET_uc011kng.1_Silent_p.V626V|MET_uc011knh.1_Silent_p.V626V|MET_uc011kni.1_Silent_p.V626V|MET_uc011knj.1_Silent_p.V196V	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	626	Extracellular (Potential).|IPT/TIG 1.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AATGCACAGTTGGTCCTGCCA	0.353			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)			
AKR1B1	231	broad.mit.edu	37	7	134136460	134136460	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr7:134136460C>T	uc003vrp.1	-	2	186	c.112G>A	c.(112-114)GTC>ATC	p.V38I	AKR1B1_uc003vrq.1_RNA	NM_001628	NP_001619	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1	38					C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding			ovary(3)	3					NADH(DB00157)|Sulindac(DB00605)	CGGTACCCGACGTCAATGGCC	0.587												
BRAF	673	broad.mit.edu	37	7	140453133	140453133	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr7:140453133T>G	uc003vwc.3	-	15	1863	c.1802A>C	c.(1801-1803)AAA>ACA	p.K601T		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	601	Protein kinase.		K -> Q (in CFC syndrome).|K -> E (in colorectal cancer).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.K601E(47)|p.V600_K601>E(8)|p.K601N(7)|p.K601del(4)|p.K601Q(3)|p.T599_R603>I(2)|p.V600_W604del(1)|p.K601K(1)|p.K601L(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.K601I(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	CCATCGAGATTTCACTGTAGC	0.373		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome			
CLN8	2055	broad.mit.edu	37	8	1728422	1728422	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr8:1728422T>G	uc003wpo.3	+	3	855	c.550T>G	c.(550-552)TGG>GGG	p.W184G		NM_018941	NP_061764	Q9UBY8	CLN8_HUMAN	ceroid-lipofuscinosis, neuronal 8	184	TLC.				cell death|ceramide biosynthetic process|cholesterol metabolic process|lipid transport|negative regulation of proteolysis|phospholipid metabolic process	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.67e-05)|READ - Rectum adenocarcinoma(644;0.0913)		GCAGGCGGGCTGGTCCGAGTC	0.458												
WRN	7486	broad.mit.edu	37	8	30938688	30938688	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr8:30938688A>C	uc003xio.3	+	9	1933	c.1145A>C	c.(1144-1146)AAA>ACA	p.K382T	WRN_uc011lbd.1_Missense_Mutation_p.K85T|WRN_uc011lbe.1_5'Flank	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	382					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		GAAGACAACAAATTGAAAGAG	0.348			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome			
RP1	6101	broad.mit.edu	37	8	55542502	55542502	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr8:55542502T>G	uc003xsd.1	+	4	6208	c.6060T>G	c.(6058-6060)AAT>AAG	p.N2020K	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	2020					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGAAGGTAATTTAAAGAAAT	0.308												
ZFPM2	23414	broad.mit.edu	37	8	106813505	106813505	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr8:106813505C>T	uc003ymd.2	+	8	1218	c.1195C>T	c.(1195-1197)CAC>TAC	p.H399Y	ZFPM2_uc011lhs.1_Missense_Mutation_p.H130Y|uc003yme.1_5'Flank	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	399					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TGACATGGAACACTCTCCAAG	0.507												
CSMD3	114788	broad.mit.edu	37	8	113418874	113418874	+	Silent	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr8:113418874G>A	uc003ynu.2	-	35	5847	c.5688C>T	c.(5686-5688)GTC>GTT	p.V1896V	CSMD3_uc003yns.2_Silent_p.V1098V|CSMD3_uc003ynt.2_Silent_p.V1856V|CSMD3_uc011lhx.1_Silent_p.V1792V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1896	Sushi 10.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCGATGAACCGACTGCAAATT	0.403										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
COL14A1	7373	broad.mit.edu	37	8	121170389	121170389	+	Silent	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr8:121170389A>C	uc003yox.2	+	3	374	c.109A>C	c.(109-111)AGA>CGA	p.R37R		NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	37	Fibronectin type-III 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CACAAGGTTAAGATATAATGT	0.343												
NAPRT1	93100	broad.mit.edu	37	8	144658639	144658639	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr8:144658639G>A	uc003yym.3	-	7	1010	c.985C>T	c.(985-987)CAG>TAG	p.Q329*	NAPRT1_uc003yyn.3_Nonsense_Mutation_p.Q329*|NAPRT1_uc011lkh.1_Nonsense_Mutation_p.Q329*|NAPRT1_uc003yyo.3_Nonsense_Mutation_p.Q329*	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	329					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CGGATCTCCTGAGCCTGCTGT	0.657												
MLLT3	4300	broad.mit.edu	37	9	20414419	20414419	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr9:20414419G>A	uc003zoe.2	-	5	684	c.425C>T	c.(424-426)CCT>CTT	p.P142L	MLLT3_uc011lne.1_Missense_Mutation_p.P110L|MLLT3_uc011lnf.1_Missense_Mutation_p.P139L|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Missense_Mutation_p.P110L	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		ACTCCTATTAGGGTCCTGCAA	0.209			T	MLL	ALL							
PIGO	84720	broad.mit.edu	37	9	35091599	35091599	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr9:35091599G>A	uc003zwd.2	-	7	2681	c.2285C>T	c.(2284-2286)CCT>CTT	p.P762L	PIGO_uc003zwc.1_3'UTR|PIGO_uc003zwe.2_Intron|PIGO_uc003zwf.2_Intron|PIGO_uc003zwg.1_Missense_Mutation_p.P325L	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	762	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CACTGTCACAGGCTTCCAGAG	0.647												
INVS	27130	broad.mit.edu	37	9	103015323	103015323	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr9:103015323A>T	uc004bap.1	+	10	1581	c.1369A>T	c.(1369-1371)AGA>TGA	p.R457*	INVS_uc010mta.1_Nonsense_Mutation_p.R361*|INVS_uc011lve.1_Nonsense_Mutation_p.R361*|INVS_uc004bao.1_Nonsense_Mutation_p.R457*|INVS_uc004baq.1_Nonsense_Mutation_p.R361*|INVS_uc004bar.1_Nonsense_Mutation_p.R361*|INVS_uc010mtb.1_Nonsense_Mutation_p.R131*	NM_014425	NP_055240	Q9Y283	INVS_HUMAN	inversin isoform a	457	ANK 14.				negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.056)				TTATGCAGGAAGAACCCCTTT	0.418												
C9orf84	158401	broad.mit.edu	37	9	114454546	114454546	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr9:114454546T>G	uc004bfr.2	-	25	3654	c.3519A>C	c.(3517-3519)AAA>AAC	p.K1173N	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Missense_Mutation_p.K1134N|C9orf84_uc010mug.2_Missense_Mutation_p.K1084N	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	1173										ovary(2)	2						TTGAGATTTCTTTTAGTTCCA	0.358												
SLC46A2	57864	broad.mit.edu	37	9	115651953	115651953	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr9:115651953C>T	uc004bgk.2	-	1	1241	c.1009G>A	c.(1009-1011)GGT>AGT	p.G337S		NM_033051	NP_149040	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	337	Helical; Name=8; (Potential).					integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)	1						ACCAGGACACCCAGGAAGCTG	0.547												
TNC	3371	broad.mit.edu	37	9	117835903	117835903	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr9:117835903C>T	uc004bjj.3	-	10	3555	c.3193G>A	c.(3193-3195)GCA>ACA	p.A1065T	TNC_uc010mvf.2_Missense_Mutation_p.A1065T	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1065	Fibronectin type-III 5.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						TTCACACGTGCGGGCTTGCTC	0.542												
OR1B1	347169	broad.mit.edu	37	9	125391471	125391471	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr9:125391471A>G	uc011lyz.1	-	1	344	c.344T>C	c.(343-345)CTT>CCT	p.L115P		NM_001004450	NP_001004450	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGCAATGACAAGTGTATCTGT	0.502												
DBH	1621	broad.mit.edu	37	9	136516786	136516786	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr9:136516786G>A	uc004cel.2	+	7	1231	c.1222G>A	c.(1222-1224)GCC>ACC	p.A408T		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	408	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CCACATCTTCGCCTCTCAGCT	0.657												
SOHLH1	402381	broad.mit.edu	37	9	138588459	138588459	+	Silent	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr9:138588459T>C	uc004cgl.2	-	5	721	c.660A>G	c.(658-660)TCA>TCG	p.S220S	SOHLH1_uc010nbe.2_Silent_p.S220S	NM_001012415	NP_001012415	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic	220					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		AGGACTCACCTGAGAAAGGGG	0.657												
TAB3	257397	broad.mit.edu	37	X	30852177	30852177	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:30852177C>T	uc004dcj.2	-	10	2644	c.1981G>A	c.(1981-1983)GCT>ACT	p.A661T	TAB3_uc004dck.2_Missense_Mutation_p.A661T|TAB3_uc010ngl.2_Missense_Mutation_p.A633T	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	661	Poly-Ala.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						CCATCTGCAGCTGCTGCCTGG	0.433												
BCOR	54880	broad.mit.edu	37	X	39916463	39916463	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:39916463G>A	uc004den.3	-	11	4832	c.4540C>T	c.(4540-4542)CGA>TGA	p.R1514*	BCOR_uc004dep.3_Nonsense_Mutation_p.R1480*|BCOR_uc004deo.3_Nonsense_Mutation_p.R1462*|BCOR_uc010nhb.2_Nonsense_Mutation_p.R222*|BCOR_uc004dem.3_Nonsense_Mutation_p.R1480*	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1514	ANK 2.				heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						AGGAGGTGTCGCACAATGTTG	0.512												
MED14	9282	broad.mit.edu	37	X	40513617	40513617	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:40513617T>G	uc004dex.3	-	30	4430	c.4290A>C	c.(4288-4290)CAA>CAC	p.Q1430H	MED14_uc004dey.1_Missense_Mutation_p.Q332H	NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	1430					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						GTCATGTACCTTGTCGTGGTG	0.438												
USP9X	8239	broad.mit.edu	37	X	41027344	41027344	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:41027344A>G	uc004dfb.2	+	18	3142	c.2509A>G	c.(2509-2511)AAA>GAA	p.K837E	USP9X_uc004dfc.2_Missense_Mutation_p.K837E	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	837					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GGATGGTGACAAAGACAGTGT	0.383												
ITIH5L	347365	broad.mit.edu	37	X	54814956	54814956	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:54814956A>C	uc004dtj.2	-	5	773	c.743T>G	c.(742-744)GTT>GGT	p.V248G		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	248					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						ATCGTACTGAACCAGGAAGTC	0.577												
ATRX	546	broad.mit.edu	37	X	76918944	76918944	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:76918944G>T	uc004ecp.3	-	12	4279	c.4047C>A	c.(4045-4047)GAC>GAA	p.D1349E	ATRX_uc004ecq.3_Missense_Mutation_p.D1311E|ATRX_uc004eco.3_Missense_Mutation_p.D1134E|ATRX_uc004ecr.2_Missense_Mutation_p.D1281E	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1349					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CAGATTCTCCGTCACTCACAG	0.358			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome					
CYLC1	1538	broad.mit.edu	37	X	83128752	83128752	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:83128752G>T	uc004eei.1	+	4	1057	c.1036G>T	c.(1036-1038)GAT>TAT	p.D346Y	CYLC1_uc004eeh.1_Missense_Mutation_p.D345Y	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	346	3.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						tgaaaggaaagatacaaagaa	0.249												
RPA4	29935	broad.mit.edu	37	X	96139827	96139827	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:96139827G>A	uc004efv.3	+	1	816	c.518G>A	c.(517-519)CGT>CAT	p.R173H	DIAPH2_uc004eft.3_Intron|DIAPH2_uc004efu.3_Intron|DIAPH2_uc004efs.2_Intron	NM_013347	NP_037479	Q13156	RFA4_HUMAN	replication protein A4, 34kDa	173					DNA damage checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair	DNA replication factor A complex|nucleoplasm	single-stranded DNA binding				0						AAAGCCCGTCGTGATACCACT	0.468								Other_identified_genes_with_known_or_suspected_DNA_repair_function				
ZMAT1	84460	broad.mit.edu	37	X	101138752	101138752	+	Silent	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:101138752T>C	uc004eim.2	-	2	4632	c.1134A>G	c.(1132-1134)AAA>AAG	p.K378K	ZMAT1_uc011mrl.1_Silent_p.K549K|ZMAT1_uc004ein.2_Silent_p.K378K|ZMAT1_uc011mrm.1_Silent_p.K378K	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	378						nucleus	zinc ion binding			ovary(1)	1						CTGGCCTTTCTTTGCCTTCTT	0.393												
GLRA4	441509	broad.mit.edu	37	X	102978850	102978850	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:102978850A>T	uc011mse.1	-	5	932	c.511T>A	c.(511-513)TCC>ACC	p.S171T	GLRA4_uc010nou.2_Missense_Mutation_p.S171T	NM_001024452	NP_001019623	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4 precursor	171	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity				0						ATCAGGCAGGACAAAATGAGG	0.483												
AIFM1	9131	broad.mit.edu	37	X	129267364	129267364	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:129267364C>T	uc004evg.2	-	13	1550	c.1372G>A	c.(1372-1374)GCT>ACT	p.A458T	AIFM1_uc011mur.1_Missense_Mutation_p.A106T|AIFM1_uc011mus.1_3'UTR|AIFM1_uc004evh.2_Missense_Mutation_p.A454T|AIFM1_uc004evi.2_Missense_Mutation_p.A171T|AIFM1_uc004evk.2_RNA	NM_004208	NP_004199	O95831	AIFM1_HUMAN	programmed cell death 8 isoform 1	458	FAD-dependent oxidoreductase (By similarity).				activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(4)|central_nervous_system(1)	5						CTCACAACAGCGTGATCATGG	0.468												
SAGE1	55511	broad.mit.edu	37	X	134987488	134987488	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:134987488G>A	uc004ezh.2	+	5	558	c.391G>A	c.(391-393)GCT>ACT	p.A131T	SAGE1_uc010nry.1_Missense_Mutation_p.A100T|SAGE1_uc011mvv.1_Missense_Mutation_p.A131T	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	131										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CTTGTCAACTGCTCCACCACA	0.458												
SAGE1	55511	broad.mit.edu	37	X	134991106	134991106	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:134991106C>A	uc004ezh.2	+	13	1692	c.1525C>A	c.(1525-1527)CCA>ACA	p.P509T	SAGE1_uc010nry.1_Missense_Mutation_p.P478T|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	509										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AAATGATGCACCACAGCTTGG	0.423												
MAMLD1	10046	broad.mit.edu	37	X	149639020	149639020	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:149639020C>T	uc004fee.1	+	3	1251	c.1175C>T	c.(1174-1176)ACG>ATG	p.T392M	MAMLD1_uc011mxt.1_Missense_Mutation_p.T354M|MAMLD1_uc011mxu.1_Missense_Mutation_p.T367M|MAMLD1_uc011mxv.1_Missense_Mutation_p.T367M|MAMLD1_uc011mxw.1_Missense_Mutation_p.T319M	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	392					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					TCAAGCATGACGTCCAGCAGC	0.602												
GABRA3	2556	broad.mit.edu	37	X	151424324	151424324	+	Silent	SNP	T	T	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:151424324T>C	uc010ntk.1	-	5	717	c.477A>G	c.(475-477)TCA>TCG	p.S159S		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	159	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TATGAGCCACTGATTTCTTGC	0.498												
PLXNB3	5365	broad.mit.edu	37	X	153040751	153040751	+	Silent	SNP	G	G	A			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:153040751G>A	uc004fii.2	+	25	4401	c.4227G>A	c.(4225-4227)TCG>TCA	p.S1409S	PLXNB3_uc010nuk.2_Silent_p.S1432S|PLXNB3_uc011mzd.1_Silent_p.S1048S|PLXNB3_uc004fij.1_Intron|SRPK3_uc004fik.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1409	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CGCTGCTGTCGCTAGCGCTAC	0.627												
F8	2157	broad.mit.edu	37	X	154225316	154225316	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chrX:154225316A>C	uc004fmt.2	-	3	491	c.320T>G	c.(319-321)CTT>CGT	p.L107R	F8_uc011mzx.1_Missense_Mutation_p.L72R	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	107	Plastocyanin-like 1.|F5/8 type A 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CATGTTCTTAAGTGTAATGAC	0.458												
GSTA4	2941	broad.mit.edu	37	6	52852195	52852197	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr6:52852194_52852196ATTC>A	uc003pbf.3	-	2	248_250	c.98_100GAAT>T	c.(97-102)gaattt>gTtt	p.33_34EF>V	GSTA4_uc003pbd.3_Intron	NM_001512	NP_001503	O15217	GSTA4_HUMAN	Homo sapiens glutathione S-transferase alpha 4 (GSTA4), mRNA.	33	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity|protein homodimerization activity			endometrium(1)|lung(3)|skin(2)|urinary_tract(1)	7	Lung NSC(77;0.103)				Glutathione(DB00143)	GTTTCCAGAAATTCTTCATCAAA	0.310												
AOC3	8639	broad.mit.edu	37	17	41003597	41003598	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr17:41003596_41003597T>TG	uc002ibv.3	+	0	396_397	c.236_237T>TG	c.(235-237)ctgfs	p.L79fs		NM_003734	NP_003725	Q16853	AOC3_HUMAN	Homo sapiens amine oxidase, copper containing 3 (vascular adhesion protein 1) (AOC3), mRNA.	79					amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			breast(1)|central_nervous_system(4)|endometrium(4)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|skin(8)	41		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	ACCCAGCGGCTGGGGCCAGGGC	0.658												
LENG9	94059	broad.mit.edu	37	19	54973460	54973461	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-BR-8366-01A-11D-2340-08	TCGA-BR-8366-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1abcee1-9890-44fc-b2b3-e506b7a7328b	5f6c1c99-0981-4fbf-93b5-8ad581ab25b6	g.chr19:54973459_54973460CTG>C	uc010yez.2	-	0	1435_1436	c.1316_1317CAG>G	c.(1315-1317)cagfs	p.Q439fs		NM_198988	NP_945339	Q96B70	LENG9_HUMAN	Homo sapiens leukocyte receptor cluster (LRC) member 9 (LENG9), mRNA.	439					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)	11	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)		GCCCTGGAGACTGTAGTGTACT	0.644