Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
PRDM2	7799	broad.mit.edu	37	1	14142940	14142940	+	Silent	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr1:14142940G>A	uc001avi.2	+	9	5911	c.5055G>A	c.(5053-5055)GCG>GCA	p.A1685A	PRDM2_uc001avg.2_Missense_Mutation_p.R177H|PRDM2_uc009voe.2_RNA|PRDM2_uc009vof.2_RNA	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1685						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		TCCGCTTGGCGTCCCGATGCT	0.587												
HIVEP3	59269	broad.mit.edu	37	1	42047175	42047175	+	Silent	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr1:42047175G>A	uc001cgz.3	-	4	4507	c.3294C>T	c.(3292-3294)CCC>CCT	p.P1098P	HIVEP3_uc001cha.3_Silent_p.P1098P|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1098					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGCCTCCCGGGGGTCCACCAT	0.612												
INSRR	3645	broad.mit.edu	37	1	156816537	156816537	+	Silent	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr1:156816537G>A	uc010pht.1	-	8	1838	c.1584C>T	c.(1582-1584)AAC>AAT	p.N528N	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	528	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCTCTGTGGCGTTCTGGAATG	0.617												
LRRN2	10446	broad.mit.edu	37	1	204587773	204587773	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr1:204587773C>T	uc001hbe.1	-	3	1736	c.1348G>A	c.(1348-1350)GAA>AAA	p.E450K	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.E450K|LRRN2_uc009xbf.1_Missense_Mutation_p.E450K|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	450	Ig-like C2-type.|Extracellular (Potential).				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GGTTCGGGTTCGGCCAGTGCC	0.642												
SLK	9748	broad.mit.edu	37	10	105777982	105777982	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr10:105777982A>C	uc001kxo.1	+	14	2976	c.2942A>C	c.(2941-2943)CAG>CCG	p.Q981P	SLK_uc001kxp.1_Missense_Mutation_p.Q950P	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	981	Potential.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		ATCATCCAGCAGCAGAAGGCA	0.338												
TSSC4	10078	broad.mit.edu	37	11	2424220	2424220	+	Silent	SNP	C	C	T	rs142339475		TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr11:2424220C>T	uc001lwj.2	+	4	718	c.357C>T	c.(355-357)AAC>AAT	p.N119N	TSSC4_uc001lwi.2_Silent_p.N55N|TSSC4_uc001lwk.2_Silent_p.N119N|TSSC4_uc001lwl.2_Silent_p.N119N	NM_005706	NP_005697	Q9Y5U2	TSSC4_HUMAN	tumor suppressing subtransferable candidate 4	119											0		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.00145)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAGTGACAACGGAGGCTTCA	0.682												
UBQLN3	50613	broad.mit.edu	37	11	5530122	5530122	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr11:5530122A>G	uc001may.1	-	2	753	c.667T>C	c.(667-669)TTT>CTT	p.F223L	HBG2_uc001mak.1_Intron	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	223										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTACGTAAAAACTCCAGTGTC	0.507												
SCUBE2	57758	broad.mit.edu	37	11	9069615	9069615	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr11:9069615C>T	uc001mhh.1	-	14	1663	c.1583G>A	c.(1582-1584)CGC>CAC	p.R528H	SCUBE2_uc001mhi.1_Missense_Mutation_p.R557H|SCUBE2_uc001mhj.1_Intron	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	528						extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		GTTTACGTAGCGGAAGCTCTC	0.473												
OR5R1	219479	broad.mit.edu	37	11	56184809	56184809	+	Silent	SNP	G	G	C			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr11:56184809G>C	uc010rji.1	-	1	900	c.900C>G	c.(898-900)GCC>GCG	p.A300A		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CTTTCTTTGAGGCATCTTTCA	0.333												
SERPING1	710	broad.mit.edu	37	11	57373905	57373905	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr11:57373905C>T	uc001nkp.1	+	6	1105	c.914C>T	c.(913-915)CCC>CTC	p.P305L	SERPING1_uc001nkq.1_Missense_Mutation_p.P305L|SERPING1_uc010rju.1_Missense_Mutation_p.P253L|SERPING1_uc010rjv.1_Missense_Mutation_p.P310L|SERPING1_uc001nkr.1_Missense_Mutation_p.P305L|SERPING1_uc009ymi.1_Missense_Mutation_p.P314L|SERPING1_uc009ymj.1_Missense_Mutation_p.P305L|SERPING1_uc001nks.1_5'UTR	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	305					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						ACATTTGATCCCAAGAAAACC	0.438									Hereditary_Angioedema			
GRM5	2915	broad.mit.edu	37	11	88583181	88583181	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr11:88583181C>A	uc001pcq.2	-	2	1004	c.804G>T	c.(802-804)TTG>TTT	p.L268F	GRM5_uc009yvm.2_Missense_Mutation_p.L268F	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	268	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GGGCCTTGGGCAAGTGACTTG	0.552												
SPA17	53340	broad.mit.edu	37	11	124551345	124551345	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr11:124551345A>G	uc001qap.2	+	3	351	c.215A>G	c.(214-216)CAT>CGT	p.H72R		NM_017425	NP_059121	Q15506	SP17_HUMAN	sperm autoantigenic protein 17	72					binding of sperm to zona pellucida|ciliary or flagellar motility|signal transduction|spermatogenesis	cytoplasm|flagellum|membrane|motile cilium|primary cilium	cAMP-dependent protein kinase regulator activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0223)		TATAACAATCATGCATTCGAG	0.363												
SLC6A13	6540	broad.mit.edu	37	12	333238	333238	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr12:333238G>A	uc001qic.1	-	11	1284	c.1231C>T	c.(1231-1233)CGC>TGC	p.R411C	SLC6A13_uc009zdj.1_Missense_Mutation_p.R401C|SLC6A13_uc010sdl.1_Missense_Mutation_p.R319C	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	411					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			TTCTTCTTGCGGAACACGTGA	0.572												
FKBP3	2287	broad.mit.edu	37	14	45603647	45603647	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr14:45603647C>G	uc010tqf.1	-	1	86	c.13G>C	c.(13-15)GTT>CTT	p.V5L	FANCM_uc001wwc.2_5'Flank|FANCM_uc001wwd.3_5'Flank|FANCM_uc010anf.2_5'Flank	NM_002013	NP_002004	Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	5					protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity				0						CGCTGTGGAACGGCCGCCGCC	0.667												
PNMA1	9240	broad.mit.edu	37	14	74179980	74179980	+	Silent	SNP	A	A	G			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr14:74179980A>G	uc001xor.1	-	1	1149	c.363T>C	c.(361-363)CGT>CGC	p.R121R		NM_006029	NP_006020	Q8ND90	PNMA1_HUMAN	paraneoplastic antigen MA1	121					apoptosis|central nervous system development|inflammatory response to antigenic stimulus|spermatogenesis	cytoplasm|focal adhesion|nucleolus	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00331)|KIRC - Kidney renal clear cell carcinoma(182;0.0797)		acccaaggacacgggcaacat	0												
RHBDF1	64285	broad.mit.edu	37	16	112868	112868	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr16:112868G>A	uc002cfl.3	-	9	848	c.700C>T	c.(700-702)CGC>TGC	p.R234C	RHBDF1_uc010uty.1_Missense_Mutation_p.R257C|RHBDF1_uc010utz.1_Missense_Mutation_p.R234C|RHBDF1_uc010bqo.1_RNA	NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	234	Cytoplasmic (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				TGTGCCCGGCGAAAGGTGCCA	0.637												
ZSCAN10	84891	broad.mit.edu	37	16	3140332	3140332	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr16:3140332C>T	uc002ctv.1	-	5	1026	c.938G>A	c.(937-939)CGC>CAC	p.R313H	ZSCAN10_uc002cty.1_5'UTR|ZSCAN10_uc002ctw.1_Missense_Mutation_p.R231H|ZSCAN10_uc002ctx.1_Missense_Mutation_p.R241H	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	313	C2H2-type 1.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CGGGTGCGAGCGCAGCTGGTG	0.667												
SALL1	6299	broad.mit.edu	37	16	51174200	51174200	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr16:51174200G>C	uc010vgs.1	-	2	1964	c.1933C>G	c.(1933-1935)CCA>GCA	p.P645A	SALL1_uc010vgr.1_Missense_Mutation_p.P548A|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	645					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TCTGCCGCTGGGGAGCTCAGG	0.627												
CDH8	1006	broad.mit.edu	37	16	61687818	61687818	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr16:61687818C>A	uc002eog.1	-	12	2346	c.2094G>T	c.(2092-2094)AAG>AAT	p.K698N		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	698	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GTTTAATATCCTTACGGGGTA	0.423												
MINK1	50488	broad.mit.edu	37	17	4794803	4794803	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr17:4794803G>A	uc010vsl.1	+	16	1989	c.1793G>A	c.(1792-1794)CGA>CAA	p.R598Q	MINK1_uc010vsk.1_Missense_Mutation_p.R598Q|MINK1_uc010vsm.1_Intron|MINK1_uc010vsn.1_Missense_Mutation_p.R598Q|MINK1_uc010vso.1_Missense_Mutation_p.R543Q|MINK1_uc010vsp.1_Missense_Mutation_p.R88Q	NM_153827	NP_722549	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1 isoform 3	598					JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)|skin(1)	6						CCTGTACCCCGATCCCAGTCC	0.672												
GLP2R	9340	broad.mit.edu	37	17	9792816	9792816	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr17:9792816G>A	uc002gmd.1	+	13	1456	c.1456G>A	c.(1456-1458)GGC>AGC	p.G486S		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	486	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	GGAAGGAGATGGCGCTGAGAA	0.607												
PTRF	284119	broad.mit.edu	37	17	40556837	40556837	+	Silent	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr17:40556837G>A	uc002hzo.2	-	2	1200	c.1041C>T	c.(1039-1041)GAC>GAT	p.D347D	PTRF_uc010wgi.1_Silent_p.D329D	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	347					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		CCTCGTCGTCGTCGGCGCCCA	0.706												
SKAP1	8631	broad.mit.edu	37	17	46262101	46262101	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr17:46262101T>C	uc002ini.1	-	7	663	c.551A>G	c.(550-552)GAT>GGT	p.D184G	SKAP1_uc002inj.1_Missense_Mutation_p.D184G|SKAP1_uc010dbd.1_Missense_Mutation_p.D90G|SKAP1_uc010dbe.1_Missense_Mutation_p.D184G	NM_003726	NP_003717	Q86WV1	SKAP1_HUMAN	src kinase associated phosphoprotein 1 isoform	184	PH.				positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding				0						GCTGCGCCTATCCTGGGAGGT	0.522												
PRPSAP1	5635	broad.mit.edu	37	17	74309056	74309056	+	Silent	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr17:74309056C>T	uc010wta.1	-	9	1340	c.894G>A	c.(892-894)GCG>GCA	p.A298A	PRPSAP1_uc010wtb.1_Silent_p.A195A	NM_002766	NP_002757	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate	269					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			ovary(1)	1						TCAGGATCTCCGCGGCAGCAA	0.522												
KIAA0802	23255	broad.mit.edu	37	18	8784659	8784659	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr18:8784659G>A	uc002knr.2	+	6	1691	c.1549G>A	c.(1549-1551)GCC>ACC	p.A517T	KIAA0802_uc002knq.2_Missense_Mutation_p.A517T|KIAA0802_uc010dkw.1_Missense_Mutation_p.A355T	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	868											0						GACCATCAACGCCAAGATGAA	0.652												
NFIC	4782	broad.mit.edu	37	19	3452579	3452579	+	Missense_Mutation	SNP	G	G	A	rs140170107		TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr19:3452579G>A	uc010xhi.1	+	8	1246	c.1184G>A	c.(1183-1185)CGC>CAC	p.R395H	NFIC_uc002lxo.2_Missense_Mutation_p.R386H|NFIC_uc010xhh.1_Missense_Mutation_p.R386H|NFIC_uc002lxp.2_Missense_Mutation_p.R395H|NFIC_uc010xhj.1_Missense_Mutation_p.R395H	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	395					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		ACGGCCATCCGCTACCCACCT	0.662												
NPHS1	4868	broad.mit.edu	37	19	36322010	36322010	+	Silent	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr19:36322010C>T	uc002oby.2	-	27	3426	c.3426G>A	c.(3424-3426)CTG>CTA	p.L1142L	NPHS1_uc010eem.1_RNA	NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	1142	Cytoplasmic (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGAAGTCCCTCAGGGAGCGGT	0.587												
PSG7	5676	broad.mit.edu	37	19	43433795	43433795	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr19:43433795C>T	uc002ovl.3	-	4	610	c.508G>A	c.(508-510)GAT>AAT	p.D170N	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_5'Flank|PSG7_uc002out.1_5'UTR|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.D48N	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	170	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				GTCTCAGGATCACAGGTTAAA	0.527												
IRGQ	126298	broad.mit.edu	37	19	44097366	44097366	+	Silent	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr19:44097366G>A	uc002oww.2	-	2	802	c.684C>T	c.(682-684)GCC>GCT	p.A228A	IRGQ_uc010eiv.2_Silent_p.A228A	NM_001007561	NP_001007562	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	228							protein binding			ovary(1)|pancreas(1)	2		Prostate(69;0.0199)				TGCCAGCCACGGCCAGGTCTA	0.687												
ZNF432	9668	broad.mit.edu	37	19	52538109	52538109	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr19:52538109G>A	uc002pyk.2	-	5	1141	c.823C>T	c.(823-825)CGT>TGT	p.R275C		NM_014650	NP_055465	O94892	ZN432_HUMAN	zinc finger protein 432	275	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|pancreas(1)	3		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		TCAATCAGACGGCTCTTCATA	0.393												
ZNF480	147657	broad.mit.edu	37	19	52817468	52817468	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr19:52817468C>G	uc010ydl.1	+	3	205	c.135C>G	c.(133-135)GAC>GAG	p.D45E	ZNF480_uc002pyv.2_Intron|ZNF480_uc010ydm.1_Missense_Mutation_p.D45E|ZNF480_uc010epn.2_Intron|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	45	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		AATGCCTGGACCCTGCACAGA	0.502												
ZNF468	90333	broad.mit.edu	37	19	53344459	53344459	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr19:53344459A>G	uc002qaf.2	-	4	1239	c.1088T>C	c.(1087-1089)GTT>GCT	p.V363A	ZNF468_uc002qae.2_Missense_Mutation_p.V310A	NM_001008801	NP_001008801	Q5VIY5	ZN468_HUMAN	zinc finger protein ZNF468 isoform 2	363	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0358)		TCGATTAAAAACTTTGCCACA	0.378												
ZNF347	84671	broad.mit.edu	37	19	53644778	53644778	+	Missense_Mutation	SNP	C	C	T	rs146644074		TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr19:53644778C>T	uc002qbb.1	-	5	1372	c.1303G>A	c.(1303-1305)GGC>AGC	p.G435S	ZNF347_uc010eql.1_Missense_Mutation_p.G436S|ZNF347_uc002qbc.1_Missense_Mutation_p.G436S	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	435	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		AAGGCTTTGCCGCACTCATTA	0.428												
ZNF470	388566	broad.mit.edu	37	19	57088331	57088331	+	Silent	SNP	G	G	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr19:57088331G>T	uc002qnl.3	+	6	1210	c.534G>T	c.(532-534)GGG>GGT	p.G178G	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		ACAAATCTGGGACAGTTTTTC	0.313												
NEB	4703	broad.mit.edu	37	2	152385745	152385745	+	Silent	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr2:152385745G>A	uc010fnx.2	-	118	16802	c.16611C>T	c.(16609-16611)GAC>GAT	p.D5537D	NEB_uc002txr.2_Silent_p.D1960D|NEB_uc002txt.3_Silent_p.D42D	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5537	Nebulin 151.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTTTGTAGGCGTCCTTGGCTG	0.438												
TTN	7273	broad.mit.edu	37	2	179587650	179587650	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr2:179587650C>T	uc010zfg.1	-	73	18468	c.18244G>A	c.(18244-18246)GTT>ATT	p.V6082I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V2743I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7009							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTCCGTAACAAAATAAGGC	0.403												
PLCL1	5334	broad.mit.edu	37	2	198949579	198949579	+	Silent	SNP	A	A	C			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr2:198949579A>C	uc010fsp.2	+	2	1629	c.1338A>C	c.(1336-1338)GTA>GTC	p.V446V	PLCL1_uc002uuv.3_Silent_p.V367V	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	446	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	AACTCGATGTAAGTGATGGTT	0.393												
D2HGDH	728294	broad.mit.edu	37	2	242683123	242683123	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr2:242683123G>A	uc002wce.1	+	5	750	c.577G>A	c.(577-579)GGA>AGA	p.G193R	D2HGDH_uc010zpc.1_RNA|D2HGDH_uc010fzq.1_Missense_Mutation_p.G59R|D2HGDH_uc002wcg.1_RNA	NM_152783	NP_689996	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase precursor	193	FAD-binding PCMH-type.				2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		GCTGGACTTAGGAGCCAAGGG	0.607												
GTSE1	51512	broad.mit.edu	37	22	46725338	46725338	+	Silent	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr22:46725338C>T	uc011aqy.1	+	11	2222	c.2010C>T	c.(2008-2010)ATC>ATT	p.I670I	GTSE1_uc011aqz.1_Silent_p.I517I|GTSE1_uc003bhn.2_RNA|uc011ara.1_5'Flank|uc003bho.3_5'Flank	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	651					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		TTCCTCTCATCGACTTCTGCG	0.502												
TUBGCP6	85378	broad.mit.edu	37	22	50664332	50664332	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr22:50664332G>A	uc003bkb.1	-	10	2386	c.1874C>T	c.(1873-1875)TCG>TTG	p.S625L	TUBGCP6_uc010har.1_Missense_Mutation_p.S625L|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_5'Flank|TUBGCP6_uc003bkd.1_5'UTR	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	625					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GAAAATCACCGAGATCCGGGG	0.597												
TRAK1	22906	broad.mit.edu	37	3	42261066	42261066	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr3:42261066G>A	uc003cky.2	+	15	2260	c.2044G>A	c.(2044-2046)GAG>AAG	p.E682K	TRAK1_uc011azi.1_Missense_Mutation_p.E661K	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	682					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						TCCTTCAGATGAGCTCACTCG	0.557												
NBEAL2	23218	broad.mit.edu	37	3	47041809	47041809	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr3:47041809C>A	uc003cqp.2	+	27	4399	c.4220C>A	c.(4219-4221)TCC>TAC	p.S1407Y	NBEAL2_uc010hjm.1_Missense_Mutation_p.S784Y|NBEAL2_uc010hjn.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1407							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CGCCACAGCTCCAGTCTCTCC	0.667												
PROS1	5627	broad.mit.edu	37	3	93615512	93615512	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr3:93615512C>G	uc003drb.3	-	9	1214	c.873G>C	c.(871-873)TTG>TTC	p.L291F	PROS1_uc010hoo.2_Missense_Mutation_p.L160F|PROS1_uc003dqz.3_Missense_Mutation_p.L160F	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	291					leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TGTCAAGGTTCAAGGGAAGGC	0.368												
KALRN	8997	broad.mit.edu	37	3	123987823	123987823	+	Silent	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr3:123987823C>T	uc003ehg.2	+	5	811	c.684C>T	c.(682-684)GAC>GAT	p.D228D	KALRN_uc010hrv.1_Silent_p.D228D|KALRN_uc003ehf.1_Silent_p.D228D|KALRN_uc011bjy.1_Silent_p.D228D	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	228	Spectrin 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GGCTCATTGACGAACACACAC	0.642												
PLXND1	23129	broad.mit.edu	37	3	129325170	129325170	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr3:129325170G>A	uc003emx.2	-	1	413	c.313C>T	c.(313-315)CAC>TAC	p.H105Y		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	105	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGCGGAGCGTGACACAGCGGG	0.711												
CRIPAK	285464	broad.mit.edu	37	4	1388882	1388882	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr4:1388882G>A	uc003gdf.2	+	1	3543	c.583G>A	c.(583-585)GTG>ATG	p.V195M		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	195					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			ACGTGCCCATGTGGAGTGCTC	0.657												
PRMT10	90826	broad.mit.edu	37	4	148575180	148575180	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr4:148575180G>A	uc003ilc.2	-	9	2010	c.1868C>T	c.(1867-1869)TCT>TTT	p.S623F	PRMT10_uc003ilb.2_Missense_Mutation_p.S267F|PRMT10_uc003ild.2_Missense_Mutation_p.S510F	NM_138364	NP_612373	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10	623						cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2						ATTGGCTTCAGATATGAGGTC	0.443												
MRPL36	64979	broad.mit.edu	37	5	1798960	1798960	+	Silent	SNP	T	T	C			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr5:1798960T>C	uc003jcx.3	-	2	153	c.90A>G	c.(88-90)CTA>CTG	p.L30L	NDUFS6_uc003jcy.2_5'Flank	NM_032479	NP_115868	Q9P0J6	RM36_HUMAN	mitochondrial ribosomal protein L36 precursor	30					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0				GBM - Glioblastoma multiforme(108;0.241)		TGGATCCAAATAGAAATGTGG	0.562												
C5orf38	153571	broad.mit.edu	37	5	2752817	2752817	+	Silent	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr5:2752817C>T	uc003jdc.2	+	2	399	c.282C>T	c.(280-282)GTC>GTT	p.V94V	C5orf38_uc011cmg.1_Silent_p.V94V|C5orf38_uc011cmh.1_RNA|C5orf38_uc011cmi.1_RNA|C5orf38_uc011cmj.1_Intron	NM_178569	NP_848664	Q86SI9	CEI_HUMAN	hypothetical protein LOC153571 precursor	94						extracellular region					0				GBM - Glioblastoma multiforme(108;0.205)		CCAGTCACGTCGAGAACGGGC	0.597												
HSPB3	8988	broad.mit.edu	37	5	53751847	53751847	+	Silent	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr5:53751847C>T	uc003jph.1	+	1	403	c.228C>T	c.(226-228)GAC>GAT	p.D76D		NM_006308	NP_006299	Q12988	HSPB3_HUMAN	heat shock 27kDa protein 3	76					cell death|response to heat|response to unfolded protein	cytoplasm|nucleus					0		Lung NSC(810;0.00104)				TCCTGCTGGACGTGGTCCAGT	0.547												
SEMA6A	57556	broad.mit.edu	37	5	115783361	115783361	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr5:115783361C>T	uc010jck.2	-	19	2750	c.2041G>A	c.(2041-2043)GTG>ATG	p.V681M	SEMA6A_uc003krx.3_Missense_Mutation_p.V698M|SEMA6A_uc011cwe.1_Missense_Mutation_p.V60M|SEMA6A_uc003krv.3_Missense_Mutation_p.V108M|SEMA6A_uc003krw.3_Missense_Mutation_p.V158M|SEMA6A_uc010jcj.2_Missense_Mutation_p.V225M	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	681	Cytoplasmic (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		ACCACAGCCACGTCTTTGCGC	0.617												
ADAMTS19	171019	broad.mit.edu	37	5	128864285	128864285	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr5:128864285G>A	uc003kvb.1	+	6	1225	c.1225G>A	c.(1225-1227)GGC>AGC	p.G409S	ADAMTS19_uc003kvc.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	409	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		TGAAGAATTTGGCAAAAAGAA	0.373												
UNC5A	90249	broad.mit.edu	37	5	176301546	176301546	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr5:176301546C>T	uc003mey.2	+	8	1549	c.1357C>T	c.(1357-1359)CGG>TGG	p.R453W	UNC5A_uc010jkg.1_Missense_Mutation_p.R413W	NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	453	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTCGGGGGCCGGCTGATGAT	0.627												
HIST1H2AG	8969	broad.mit.edu	37	6	27101073	27101073	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr6:27101073A>T	uc003niw.2	+	1	257	c.223A>T	c.(223-225)AAG>TAG	p.K75*	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	75					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						CCGCGACAACAAGAAGACCCG	0.662												
OR2W1	26692	broad.mit.edu	37	6	29012864	29012864	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr6:29012864A>C	uc003nlw.2	-	1	89	c.89T>G	c.(88-90)GTT>GGT	p.V30G		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GATGGCGACAACTCCTGACAG	0.408												
SLC44A4	80736	broad.mit.edu	37	6	31838613	31838613	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr6:31838613C>T	uc010jti.2	-	10	979	c.913G>A	c.(913-915)GTG>ATG	p.V305M	SLC44A4_uc011dol.1_Missense_Mutation_p.V229M|SLC44A4_uc011dom.1_Missense_Mutation_p.V263M	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	305	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	GTCTCCTGCACGCTCTGGTAG	0.687												
TREML2	79865	broad.mit.edu	37	6	41160244	41160244	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr6:41160244C>A	uc010jxm.1	-	5	1066	c.887G>T	c.(886-888)AGC>ATC	p.S296I		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	296	Cytoplasmic (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					CATGCTGTAGCCTGCAAGAAA	0.592												
TMEM195	392636	broad.mit.edu	37	7	15425094	15425094	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr7:15425094C>T	uc003stb.1	-	10	1221	c.1051G>A	c.(1051-1053)GAA>AAA	p.E351K		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	351	Helical; (Potential).				ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						AAGGTCTCTTCATAAAATGCC	0.358												
AGR2	10551	broad.mit.edu	37	7	16841334	16841334	+	Silent	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr7:16841334G>A	uc003str.2	-	2	274	c.87C>T	c.(85-87)GCC>GCT	p.A29A	AGR2_uc011jxy.1_Silent_p.A29A	NM_006408	NP_006399	O95994	AGR2_HUMAN	anterior gradient 2 homolog precursor	29					mucus secretion	endoplasmic reticulum|extracellular region	protein binding				0	Lung NSC(10;0.0376)|all_lung(11;0.0855)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		TGTCCTTTTTGGCTCCAGGTT	0.493												
ZNF273	10793	broad.mit.edu	37	7	64388475	64388475	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr7:64388475C>T	uc003tto.2	+	4	845	c.769C>T	c.(769-771)CCT>TCT	p.P257S	ZNF273_uc003ttl.2_Missense_Mutation_p.P192S|ZNF273_uc003ttn.2_Missense_Mutation_p.P192S	NM_021148	NP_066971	Q14593	ZN273_HUMAN	zinc finger protein 273	257					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(55;0.0295)|all_lung(88;0.0691)				GATAATTCATCCTGAAGTGAA	0.328												
CRISPLD1	83690	broad.mit.edu	37	8	75932271	75932271	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr8:75932271G>A	uc003yan.2	+	12	1576	c.1201G>A	c.(1201-1203)GAA>AAA	p.E401K	CRISPLD1_uc011lfk.1_Missense_Mutation_p.E213K|CRISPLD1_uc011lfl.1_Missense_Mutation_p.E213K	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	401	LCCL 2.					extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			AACAACTGTGGAACAGCTCTG	0.408												
KCNS2	3788	broad.mit.edu	37	8	99441350	99441350	+	Silent	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr8:99441350C>T	uc003yin.2	+	2	1493	c.1143C>T	c.(1141-1143)GTC>GTT	p.V381V		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	381						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			GGGATGTGGTCCCAGGGACCA	0.592												
CSMD3	114788	broad.mit.edu	37	8	114186070	114186070	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr8:114186070C>T	uc003ynu.2	-	4	749	c.590G>A	c.(589-591)GGG>GAG	p.G197E	CSMD3_uc003ynt.2_Missense_Mutation_p.G157E|CSMD3_uc011lhx.1_Missense_Mutation_p.G197E|CSMD3_uc010mcx.1_Missense_Mutation_p.G197E	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	197	Extracellular (Potential).|Sushi 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GATCTTGTCCCCGACGTCGAA	0.458										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
TG	7038	broad.mit.edu	37	8	133900456	133900456	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr8:133900456C>A	uc003ytw.2	+	10	2445	c.2404C>A	c.(2404-2406)CTG>ATG	p.L802M		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	802	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GCCTGCCAAGCTGCTAGTGAA	0.522												
FLJ43860	389690	broad.mit.edu	37	8	142500353	142500353	+	Silent	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr8:142500353G>A	uc003ywi.2	-	5	642	c.561C>T	c.(559-561)GAC>GAT	p.D187D	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	187							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TGCTGGCCGCGTCCTGGTATA	0.632												
GABBR2	9568	broad.mit.edu	37	9	101148039	101148039	+	Silent	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr9:101148039C>T	uc004ays.2	-	11	1701	c.1545G>A	c.(1543-1545)TCG>TCA	p.S515S		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	515	Cytoplasmic (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	TGTATGGACTCGACATCTTTA	0.388												
TGFBR1	7046	broad.mit.edu	37	9	101904872	101904872	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr9:101904872C>T	uc004azc.2	+	5	936	c.860C>T	c.(859-861)TCC>TTC	p.S287F	TGFBR1_uc004azd.2_Missense_Mutation_p.S210F|TGFBR1_uc011lvc.1_Missense_Mutation_p.S218F	NM_004612	NP_004603	P36897	TGFR1_HUMAN	transforming growth factor, beta receptor I	287	Protein kinase.|Cytoplasmic (Potential).				activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			lung(2)|ovary(1)	3		Acute lymphoblastic leukemia(62;0.0559)				GAGCATGGATCCCTTTTTGAT	0.428												
UCK1	83549	broad.mit.edu	37	9	134404543	134404543	+	Silent	SNP	G	G	A	rs149130090	byFrequency	TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr9:134404543G>A	uc004cay.2	-	4	581	c.480C>T	c.(478-480)ACC>ACT	p.T160T	UCK1_uc010mzk.2_Silent_p.T151T|UCK1_uc004cba.2_Silent_p.T160T|UCK1_uc004caz.2_RNA	NM_031432	NP_113620	Q9HA47	UCK1_HUMAN	uridine-cytidine kinase 1 isoform a	160					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;2.34e-05)|Epithelial(140;0.000219)		CGTCGGAGTCGGTGTCCACGA	0.647												
RBM3	5935	broad.mit.edu	37	X	48433596	48433596	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chrX:48433596G>A	uc004dkf.1	+	2	167	c.28G>A	c.(28-30)GTG>ATG	p.V10M	RBM3_uc004dkd.1_RNA|RBM3_uc004dkg.2_Missense_Mutation_p.V10M	NM_006743	NP_006734	P98179	RBM3_HUMAN	RNA binding motif protein 3	10	RRM.				positive regulation of translation	dendrite|nucleus	nucleotide binding|RNA binding			ovary(1)	1						AAAGCTCTTCGTGGGAGGGCT	0.502											OREG0019765	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
CYSLTR1	10800	broad.mit.edu	37	X	77528391	77528391	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chrX:77528391C>A	uc004edb.2	-	3	1253	c.853G>T	c.(853-855)GCA>TCA	p.A285S	CYSLTR1_uc010nma.2_Missense_Mutation_p.A285S|CYSLTR1_uc010nmb.2_Missense_Mutation_p.A285S	NM_006639	NP_006630	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	285	Helical; Name=7; (Potential).				elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			ovary(1)	1					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)	CAATTGGATGCAGCCAGAGAC	0.418												
ACTRT1	139741	broad.mit.edu	37	X	127185061	127185061	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chrX:127185061G>T	uc004eum.2	-	1	1322	c.1125C>A	c.(1123-1125)TGC>TGA	p.C375*		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	375						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						ATCTTTAAAAGCACCTTCTTT	0.463												
RAB39B	116442	broad.mit.edu	37	X	154493546	154493546	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chrX:154493546G>A	uc004fne.2	-	1	307	c.28C>T	c.(28-30)CGG>TGG	p.R10W		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	10					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ACAATGAGCCGGAACTGGTAC	0.687												
ARID1A	8289	broad.mit.edu	37	1	27023449	27023449	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr1:27023449delG	uc001bmv.1	+	1	928	c.555delG	c.(553-555)CAGfs	p.Q185fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.Q185fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.Q185fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	185					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.Q185*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CAGCGCTGCAGAGCGGCGGCG	0.701			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC							
STRA8	346673	broad.mit.edu	37	7	134931359	134931360	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr7:134931359_134931360insC	uc011kpx.1	+	6	637_638	c.637_638insC	c.(637-639)GCCfs	p.A213fs		NM_182489	NP_872295	Q7Z7C7	STRA8_HUMAN	STRA8	213					DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus					0						CCTGGCGGAGGCCTGCCGAGAG	0.728												
PTGS2	5743	broad.mit.edu	37	1	186645221	186645222	+	Frame_Shift_Ins	INS	-	-	ACCCA			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr1:186645220_186645221T>TACCCA	uc001gsb.3	-	7	1203_1204	c.1066_1067A>TGGGTA	c.(1066-1068)caafs	p.Q356fs	PTGS2_uc009wyo.3_Frame_Shift_Ins_p.Q203fs	NM_000963	NP_000954	P35354	PGH2_HUMAN	Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2), mRNA.	356					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)|gamma-Homolinolenic acid(DB00154)	GTACTGGAATTGTTTGTTGAAA	0.381												
CAPN7	23473	broad.mit.edu	37	3	15271957	15271957	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr3:15271956_15271956TA>T	uc003bzn.3	+	8	1216	c.946_946TA>T	c.(946-948)tacfs	p.Y316fs		NM_014296	NP_055111	Q9Y6W3	CAN7_HUMAN	Homo sapiens calpain 7 (CAPN7), mRNA.	316	Calpain catalytic.				proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|skin(2)	22						AAGCATAATTTACCCTCAAAA	0.328												
SRP72	6731	broad.mit.edu	37	4	57357732	57357735	+	Frame_Shift_Del	DEL	AGGG	AGGG	-			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr4:57357731_57357734AAGGG>A	uc003hbv.3	+	15	1677_1680	c.1637_1640AAGGG>A	c.(1636-1641)caaggafs	p.Q546fs	SRP72_uc010ihe.3_Frame_Shift_Del_p.Q485fs	NM_006947	NP_008878	O76094	SRP72_HUMAN	Homo sapiens signal recognition particle 72kDa (SRP72), mRNA.	546					SRP-dependent cotranslational protein targeting to membrane|response to drug	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(7)|ovary(2)	22	Glioma(25;0.08)|all_neural(26;0.101)					CCAAAGGAACAAGGGTAATATTTT	0.328												
NCAPD3	23310	broad.mit.edu	37	11	134086906	134086907	+	Frame_Shift_Ins	INS	-	-	CA			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr11:134086905_134086906T>TCA	uc001qhd.1	-	2	912_913	c.306_307A>TGA	c.(304-309)aagaagfs	p.K102fs	NCAPD3_uc010scm.1_Non-coding_Transcript|NCAPD3_uc009zda.1_Non-coding_Transcript	NM_015261	NP_056076	P42695	CNDD3_HUMAN	Homo sapiens non-SMC condensin II complex, subunit D3 (NCAPD3), mRNA.	102					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		CTGACATTCTTCTTATGAACTA	0.411												
CDH1	999	broad.mit.edu	37	16	68845701	68845703	+	In_Frame_Del	DEL	TGT	TGT	-			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chr16:68845700_68845702ATGT>A	uc002ewg.1	+	6	1070_1072	c.946_948ATGT>A	c.(946-948)atg>A	p.M316del	CDH1_uc010vlj.1_Non-coding_Transcript|CDH1_uc010cfg.1_In_Frame_Del_p.M316del	NM_004360	NP_004351	P12830	CADH1_HUMAN	Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1), mRNA.	316	Cadherin 2.				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	Golgi apparatus|actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.N315S(3)|p.M316V(2)|p.?(1)		NS(6)|biliary_tract(8)|breast(161)|central_nervous_system(4)|endometrium(9)|kidney(4)|large_intestine(13)|lung(13)|oesophagus(3)|ovary(2)|prostate(3)|soft_tissue(2)|stomach(76)|thyroid(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	311		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TGACAAAAATATGTTCACCATTA	0.542			"""Mis, N, F, S"""		"""lobular breast, gastric"""	gastric			Hereditary Diffuse Gastric Cancer			
SLITRK2	84631	broad.mit.edu	37	X	144906323	144906326	+	Frame_Shift_Del	DEL	AACC	AACC	-			TCGA-BR-8677-01A-11D-2394-08	TCGA-BR-8677-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df4fb014-ac78-45f4-bf7d-6d3fb15af874	193fa960-f89a-404d-b0f4-a6c5743aed4c	g.chrX:144906322_144906325AAACC>A	uc022cfn.1	+	0	2379_2382	c.2379_2382AAACC>A	c.(2377-2382)caaaacfs	p.Q793fs	SLITRK2_uc004fcd.3_Frame_Shift_Del_p.Q793fs|SLITRK2_uc010nsp.3_Frame_Shift_Del_p.Q793fs|SLITRK2_uc010nso.3_Frame_Shift_Del_p.Q793fs|SLITRK2_uc011mwq.2_Frame_Shift_Del_p.Q793fs|SLITRK2_uc011mwr.2_Frame_Shift_Del_p.Q793fs|SLITRK2_uc011mws.2_Frame_Shift_Del_p.Q793fs|SLITRK2_uc004fcg.3_Frame_Shift_Del_p.Q793fs|SLITRK2_uc011mwt.2_Frame_Shift_Del_p.Q793fs|CXorf1_uc004fch.3_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	Homo sapiens SLIT and NTRK-like family, member 2 (SLITRK2), transcript variant 1, mRNA.	793						integral to membrane		p.R792G(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					CTCGACGCCAAAACCAAGACAGAA	0.466