Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
UBIAD1	29914	broad.mit.edu	37	1	11345936	11345936	+	Silent	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:11345936G>A	uc001asg.2	+	2	1099	c.765G>A	c.(763-765)ACG>ACA	p.T255T		NM_013319	NP_037451	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	255	Helical; (Potential).				menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		TCGGCCCCACGTTCTCCTACA	0.592												
VPS13D	55187	broad.mit.edu	37	1	12337907	12337907	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:12337907G>A	uc001atv.2	+	19	4403	c.4262G>A	c.(4261-4263)CGT>CAT	p.R1421H	VPS13D_uc001atw.2_Missense_Mutation_p.R1421H|VPS13D_uc001atx.2_Missense_Mutation_p.R609H	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1421					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGAAGTGACCGTCTGCAGGTG	0.493												
DHRS3	9249	broad.mit.edu	37	1	12677213	12677213	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:12677213C>T	uc001auc.2	-	1	608	c.141G>A	c.(139-141)GGG>GGA	p.G47G	DHRS3_uc001aub.2_5'Flank|DHRS3_uc009vnm.2_Silent_p.G47G|DHRS3_uc001aud.3_Silent_p.G47G	NM_004753	NP_004744	O75911	DHRS3_HUMAN	dehydrogenase/reductase (SDR family) member 3	47					retinol metabolic process|visual perception	integral to membrane	electron carrier activity|NADP-retinol dehydrogenase activity|nucleotide binding			skin(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.11e-05)|all_lung(284;4.58e-05)|Renal(390;0.000147)|Colorectal(325;0.000585)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|Colorectal(212;9.25e-07)|COAD - Colon adenocarcinoma(227;0.000326)|BRCA - Breast invasive adenocarcinoma(304;0.000344)|Kidney(185;0.00235)|KIRC - Kidney renal clear cell carcinoma(229;0.00656)|STAD - Stomach adenocarcinoma(313;0.00798)|READ - Rectum adenocarcinoma(331;0.0419)	Vitamin A(DB00162)	CGATGCCTCTCCCGCCGCCGG	0.692												
PRDM2	7799	broad.mit.edu	37	1	14108601	14108601	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:14108601C>T	uc001avi.2	+	8	5167	c.4311C>T	c.(4309-4311)AAC>AAT	p.N1437N	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Silent_p.N1437N|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Silent_p.N1236N|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1437	Arg/Lys-rich (basic).					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		TTCAGAAAAACAAATCTGCAA	0.383												
CROCC	9696	broad.mit.edu	37	1	17264229	17264229	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:17264229C>T	uc001azt.2	+	10	1356	c.1287C>T	c.(1285-1287)GCC>GCT	p.A429A	CROCC_uc009voy.1_Silent_p.A132A|CROCC_uc009voz.1_Silent_p.A192A|CROCC_uc001azu.2_5'Flank	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	429	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		AGCTTGAGGCCCTGGTGAGCT	0.612												
ATP13A2	23400	broad.mit.edu	37	1	17331968	17331968	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:17331968C>T	uc001baa.2	-	3	379	c.189G>A	c.(187-189)CTG>CTA	p.L63L	ATP13A2_uc001bab.2_Silent_p.L63L|ATP13A2_uc001bac.2_Silent_p.L63L	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	63	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		AACGGAAGAGCAGCAAAGGGA	0.612												
LUZP1	7798	broad.mit.edu	37	1	23415425	23415425	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:23415425C>T	uc001bgk.2	-	5	3578	c.3194G>A	c.(3193-3195)CGA>CAA	p.R1065Q	LUZP1_uc010odv.1_Missense_Mutation_p.R1065Q	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	1065						nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TGGCCGTAATCGTTCCTCGGC	0.617												
RPS6KA1	6195	broad.mit.edu	37	1	26888072	26888072	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:26888072G>A	uc001bmr.1	+	17	1671	c.1508G>A	c.(1507-1509)CGG>CAG	p.R503Q	RPS6KA1_uc010ofe.1_Missense_Mutation_p.R411Q|RPS6KA1_uc010off.1_Missense_Mutation_p.R487Q|RPS6KA1_uc001bms.1_Missense_Mutation_p.R512Q|RPS6KA1_uc009vsl.1_Missense_Mutation_p.R346Q	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	503	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		AAGATCCTGCGGCAGAAGTTC	0.572												
BMP8B	656	broad.mit.edu	37	1	40253912	40253912	+	Silent	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:40253912G>A	uc001cdz.1	-	1	622	c.246C>T	c.(244-246)CAC>CAT	p.H82H	BMP8B_uc001cea.1_Silent_p.H82H	NM_001720	NP_001711	P34820	BMP8B_HUMAN	bone morphogenetic protein 8B preproprotein	82					cartilage development|cell differentiation|growth|ossification	extracellular space	cytokine activity|growth factor activity				0	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CGGCCATGGCGTGGTACAGGT	0.338												
MUTYH	4595	broad.mit.edu	37	1	45799143	45799143	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:45799143C>T	uc001cnm.2	-	3	497	c.281G>A	c.(280-282)CGA>CAA	p.R94Q	MUTYH_uc009vxn.2_Intron|MUTYH_uc001cnf.2_Missense_Mutation_p.R69Q|MUTYH_uc009vxo.2_Missense_Mutation_p.R69Q|MUTYH_uc001cng.2_Missense_Mutation_p.R80Q|MUTYH_uc001cnj.2_5'UTR|MUTYH_uc001cni.2_Missense_Mutation_p.R69Q|MUTYH_uc001cnh.2_Missense_Mutation_p.R70Q|MUTYH_uc001cno.2_5'UTR|MUTYH_uc001cnk.2_5'UTR|MUTYH_uc010oll.1_Intron|MUTYH_uc001cnl.2_Missense_Mutation_p.R83Q|MUTYH_uc009vxp.2_Missense_Mutation_p.R97Q|MUTYH_uc001cnn.2_Missense_Mutation_p.R84Q	NM_012222	NP_036354	Q9UIF7	MUTYH_HUMAN	mutY homolog isoform 1	94					depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)					CAGGCTCCCTCGGAAGGCTGT	0.607			Mis			colorectal		BER_DNA_glycosylases	MUTYH-associated_polyposis			
FNDC7	163479	broad.mit.edu	37	1	109265047	109265047	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:109265047A>T	uc001dvx.2	+	5	689	c.689A>T	c.(688-690)AAT>ATT	p.N230I	FNDC7_uc010ova.1_5'UTR	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	231	Fibronectin type-III 3.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		GGAGCTTTCAATTATACTGTG	0.488												
HRNR	388697	broad.mit.edu	37	1	152188248	152188248	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:152188248G>A	uc001ezt.1	-	3	5933	c.5857C>T	c.(5857-5859)CGA>TGA	p.R1953*		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1953	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCCATGTCGGCCACGGCTA	0.612												
SPRR1B	6699	broad.mit.edu	37	1	153005026	153005026	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:153005026G>T	uc001fba.2	+	2	269	c.205G>T	c.(205-207)GTG>TTG	p.V69L	SPRR1B_uc009wnx.1_RNA	NM_003125	NP_003116	P22528	SPR1B_HUMAN	small proline-rich protein 1B	69	5.|6 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(1)	1	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCACCCCAAGGTGCCTGAGCC	0.627												
SPTA1	6708	broad.mit.edu	37	1	158627279	158627279	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:158627279T>G	uc001fst.1	-	19	2992	c.2793A>C	c.(2791-2793)GAA>GAC	p.E931D		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	931	Spectrin 10.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CAGCTGCTTCTTCATCAGCAC	0.448												
DCAF6	55827	broad.mit.edu	37	1	167944108	167944108	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:167944108T>C	uc001gew.2	+	4	535	c.293T>C	c.(292-294)TTT>TCT	p.F98S	DCAF6_uc001gev.2_Missense_Mutation_p.F98S|DCAF6_uc001gex.2_Missense_Mutation_p.F98S|DCAF6_uc010plk.1_Missense_Mutation_p.F67S|DCAF6_uc001gey.2_5'UTR	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	98	WD 2.				positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GCAAACATATTTAGTGCAAAG	0.343												
RGS18	64407	broad.mit.edu	37	1	192153619	192153619	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:192153619C>T	uc001gsg.2	+	5	819	c.643C>T	c.(643-645)CGA>TGA	p.R215*		NM_130782	NP_570138	Q9NS28	RGS18_HUMAN	regulator of G-protein signalling 18	215					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)	3						TCTTAGGAGACGATCACGCTC	0.358												
KCNT2	343450	broad.mit.edu	37	1	196250003	196250003	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:196250003A>T	uc001gtd.1	-	25	2957	c.2897T>A	c.(2896-2898)CTT>CAT	p.L966H	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.L892H|KCNT2_uc001gtf.1_Missense_Mutation_p.L942H|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.L942H|KCNT2_uc001gth.1_Missense_Mutation_p.L463H	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	966	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						AGATGTAGTAAGTTTCTGAGA	0.328												
CFH	3075	broad.mit.edu	37	1	196684775	196684775	+	Silent	SNP	A	A	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:196684775A>G	uc001gtj.3	+	11	1812	c.1572A>G	c.(1570-1572)ACA>ACG	p.T524T		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	524	Sushi 9.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						atgacttcacatggtttaagc	0.254												
CFHR5	81494	broad.mit.edu	37	1	196971772	196971772	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:196971772G>A	uc001gts.3	+	8	1436	c.1308G>A	c.(1306-1308)TGG>TGA	p.W436*		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	436	Sushi 7.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						ATGGACGATGGCAATCATTAC	0.333												
C1orf107	27042	broad.mit.edu	37	1	210012275	210012275	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:210012275C>T	uc001hhr.1	+	7	1160	c.1084C>T	c.(1084-1086)CGG>TGG	p.R362W	C1orf107_uc009xcu.1_Missense_Mutation_p.R77W	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	362					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		GGTGCCATTCCGGGAAGCTGC	0.512												
USH2A	7399	broad.mit.edu	37	1	216462716	216462716	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:216462716C>T	uc001hku.1	-	11	2264	c.1877G>A	c.(1876-1878)CGA>CAA	p.R626Q	USH2A_uc001hkv.2_Missense_Mutation_p.R626Q	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	626	Laminin EGF-like 2.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACCAACTTGTCGGAAAAAGTA	0.413										HNSCC(13;0.011)		
NUP133	55746	broad.mit.edu	37	1	229619858	229619858	+	Missense_Mutation	SNP	G	G	A	rs144974683		TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:229619858G>A	uc001htn.2	-	12	1627	c.1535C>T	c.(1534-1536)ACT>ATT	p.T512I		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	512					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				CTGGGCTATAGTTTCATTCTT	0.313												
KIAA1217	56243	broad.mit.edu	37	10	24820922	24820922	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr10:24820922G>T	uc001iru.3	+	15	3649	c.3246G>T	c.(3244-3246)AAG>AAT	p.K1082N	KIAA1217_uc001irs.2_Missense_Mutation_p.K1002N|KIAA1217_uc001irt.3_Missense_Mutation_p.K1047N|KIAA1217_uc010qcy.1_Missense_Mutation_p.K1046N|KIAA1217_uc010qcz.1_Missense_Mutation_p.K1047N|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Missense_Mutation_p.K765N|KIAA1217_uc001irz.2_Missense_Mutation_p.K765N|KIAA1217_uc001irx.2_Missense_Mutation_p.K765N|KIAA1217_uc001iry.2_Missense_Mutation_p.K765N	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1082					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						TCACCGCTAAGGTCTGATAGG	0.532												
TMEM72	643236	broad.mit.edu	37	10	45430339	45430339	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr10:45430339G>T	uc001jbn.2	+	5	782	c.585G>T	c.(583-585)AAG>AAT	p.K195N	uc001jbk.1_Intron|uc001jbl.2_Intron|TMEM72_uc009xmm.1_Missense_Mutation_p.K77N	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	transmembrane protein 72	195						integral to membrane					0						GGACTAAGAAGCCCAGTGCCC	0.582												
HPSE2	60495	broad.mit.edu	37	10	100481490	100481490	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr10:100481490G>A	uc001kpn.1	-	5	940	c.880C>T	c.(880-882)CGG>TGG	p.R294W	HPSE2_uc009xwc.1_Missense_Mutation_p.R284W|HPSE2_uc001kpo.1_Missense_Mutation_p.R226W|HPSE2_uc009xwd.1_Missense_Mutation_p.R172W	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	294					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		GAATAAATCCGGATGGGCTGC	0.498												
PKD2L1	9033	broad.mit.edu	37	10	102051174	102051174	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr10:102051174C>T	uc001kqx.1	-	12	2274	c.1891G>A	c.(1891-1893)GCA>ACA	p.A631T	PKD2L1_uc009xwm.1_Missense_Mutation_p.A584T	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	631	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		TCATGCTCTGCGTGTCCCAGT	0.483												
PDCD11	22984	broad.mit.edu	37	10	105200216	105200216	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr10:105200216G>A	uc001kwy.1	+	29	4405	c.4318G>A	c.(4318-4320)GAG>AAG	p.E1440K		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1440					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		gaaaaggaacgagaagaagaa	0.284												
ZDHHC6	64429	broad.mit.edu	37	10	114194103	114194103	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr10:114194103A>T	uc001kzv.2	-	7	1279	c.855T>A	c.(853-855)GAT>GAA	p.D285E	ZDHHC6_uc001kzw.2_Missense_Mutation_p.D281E|ZDHHC6_uc009xya.1_Missense_Mutation_p.D285E	NM_022494	NP_071939	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	285						integral to membrane	acyltransferase activity|zinc ion binding				0		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		ACTCAAGTCCATCTCCTTCAG	0.418												
PARVA	55742	broad.mit.edu	37	11	12525930	12525930	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr11:12525930C>G	uc001mki.2	+	6	660	c.611C>G	c.(610-612)CCA>CGA	p.P204R	PARVA_uc010rck.1_Missense_Mutation_p.P151R	NM_018222	NP_060692	Q9NVD7	PARVA_HUMAN	parvin, alpha	204					cell adhesion|cell junction assembly|cilium morphogenesis	actin cytoskeleton|cytosol|focal adhesion	actin binding			breast(3)	3				Epithelial(150;0.00624)		TTCCGCGCACCAATTCGACTC	0.468												
PAX6	5080	broad.mit.edu	37	11	31824271	31824271	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr11:31824271T>A	uc001mtd.3	-	4	1012	c.122A>T	c.(121-123)GAC>GTC	p.D41V	PAX6_uc001mte.3_Missense_Mutation_p.D41V|PAX6_uc001mtg.3_Missense_Mutation_p.D41V|PAX6_uc001mtf.3_Missense_Mutation_p.D41V|PAX6_uc001mth.3_Missense_Mutation_p.D41V|PAX6_uc009yjr.2_Missense_Mutation_p.D41V	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	41	Paired.				blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)					TCGGGAAATGTCGCACGGCCG	0.632									Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation			
OR4D6	219983	broad.mit.edu	37	11	59224503	59224503	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr11:59224503G>C	uc010rku.1	+	1	70	c.70G>C	c.(70-72)GAG>CAG	p.E24Q		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCGAGAGCTGGAGTTTTTCTT	0.473												
NRXN2	9379	broad.mit.edu	37	11	64416246	64416246	+	Silent	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr11:64416246G>A	uc001oar.2	-	17	3682	c.3243C>T	c.(3241-3243)GAC>GAT	p.D1081D	NRXN2_uc001oas.2_Silent_p.D1041D|NRXN2_uc001oaq.2_Silent_p.D748D	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane		p.D1081N(1)		upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						GGTGCAGGGCGTCGGCGATGA	0.647												
SLC25A45	283130	broad.mit.edu	37	11	65144451	65144451	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr11:65144451C>T	uc001odp.1	-	5	858	c.436G>A	c.(436-438)GGG>AGG	p.G146R	SLC25A45_uc009yqi.1_Missense_Mutation_p.G84R|SLC25A45_uc001odq.1_Missense_Mutation_p.G122R|SLC25A45_uc001odr.1_Missense_Mutation_p.G146R|SLC25A45_uc001ods.1_Missense_Mutation_p.G104R|SLC25A45_uc001odt.1_Missense_Mutation_p.G104R	NM_001077241	NP_001070709	Q8N413	S2545_HUMAN	solute carrier family 25, member 45 isoform b	146	Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						TGCACGGGCCCCTGGTACCGG	0.677												
RBM14	10432	broad.mit.edu	37	11	66392900	66392900	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr11:66392900C>G	uc001oit.2	+	2	1692	c.1553C>G	c.(1552-1554)ACT>AGT	p.T518S	RBM14_uc009yrh.2_Intron|RBM14_uc009yri.2_Intron|RBM4_uc009yrj.2_Intron|RBM4_uc009yrk.2_Intron	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	518	Ala-rich.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						CCTTACCGCACTCAGTCATCA	0.652												
PHOX2A	401	broad.mit.edu	37	11	71954983	71954983	+	Silent	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr11:71954983G>A	uc001osh.3	-	1	238	c.66C>T	c.(64-66)GGC>GGT	p.G22G		NM_005169	NP_005160	O14813	PHX2A_HUMAN	paired-like homeobox 2a	22					noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGCCAAAGTCGCCGTAGGCGG	0.617												
ATM	472	broad.mit.edu	37	11	108199886	108199886	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr11:108199886T>C	uc001pkb.1	+	49	7613	c.7228T>C	c.(7228-7230)TTT>CTT	p.F2410L	ATM_uc009yxr.1_Missense_Mutation_p.F2410L|C11orf65_uc010rvx.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.F1062L|ATM_uc001pkg.1_Missense_Mutation_p.F767L	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2410	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATCATCGGAATTTGAAAACAA	0.373			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)		
POU2F3	25833	broad.mit.edu	37	11	120180168	120180168	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr11:120180168T>C	uc001pxc.2	+	10	1043	c.941T>C	c.(940-942)ATT>ACT	p.I314T	POU2F3_uc010rzk.1_Missense_Mutation_p.I268T|POU2F3_uc010rzl.1_Missense_Mutation_p.I244T|POU2F3_uc001pxe.1_Missense_Mutation_p.I99T	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	314	Homeobox.				negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		ATCTCCATGATTGCAGAGCAG	0.557												
CHD4	1108	broad.mit.edu	37	12	6687229	6687229	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr12:6687229G>A	uc001qpo.2	-	36	5358	c.5194C>T	c.(5194-5196)CGG>TGG	p.R1732W	CHD4_uc001qpn.2_Missense_Mutation_p.R1725W|CHD4_uc001qpp.2_Missense_Mutation_p.R1757W|uc001qpq.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1732	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TAGTCATGCCGTCGATGCCAG	0.478												
PRB1	5542	broad.mit.edu	37	12	11506719	11506719	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr12:11506719G>C	uc001qzw.1	-	3	355	c.318C>G	c.(316-318)AAC>AAG	p.N106K	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	167	6.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			CTTGGGGCTGGTTACCTCCTT	0.612												
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	T	rs121913530		TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr12:25398285C>T	uc001rgp.1	-	2	215	c.34G>A	c.(34-36)GGT>AGT	p.G12S	KRAS_uc001rgq.1_Missense_Mutation_p.G12S|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)		
KRT7	3855	broad.mit.edu	37	12	52627391	52627391	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr12:52627391C>G	uc001saa.1	+	1	438	c.311C>G	c.(310-312)TCC>TGC	p.S104C	KRT7_uc009zmf.1_Missense_Mutation_p.S104C	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	104	Rod.|Coil 1A.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		AAGTTTGCCTCCTTCATCGAC	0.682												
ARHGAP9	64333	broad.mit.edu	37	12	57870956	57870956	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr12:57870956C>T	uc001sod.2	-	8	1259	c.1066G>A	c.(1066-1068)GAA>AAA	p.E356K	ARHGAP9_uc001sny.2_5'Flank|ARHGAP9_uc001snz.2_Missense_Mutation_p.E101K|ARHGAP9_uc001soa.2_5'UTR|ARHGAP9_uc001sob.2_Missense_Mutation_p.E285K|ARHGAP9_uc001soc.2_Missense_Mutation_p.E285K|ARHGAP9_uc001soe.1_Missense_Mutation_p.E364K|ARHGAP9_uc010sro.1_Missense_Mutation_p.E285K	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	285					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			TCAAGCGGTTCTGGGGTCCCT	0.517												
XPOT	11260	broad.mit.edu	37	12	64816815	64816815	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr12:64816815A>G	uc001ssb.2	+	10	1537	c.1111A>G	c.(1111-1113)AAT>GAT	p.N371D		NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	371	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		GCAAAAAGCTAATGTAGAGGT	0.294												
TPH2	121278	broad.mit.edu	37	12	72372834	72372834	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr12:72372834G>A	uc009zrw.1	+	7	1049	c.908G>A	c.(907-909)CGG>CAG	p.R303Q	TPH2_uc001swy.2_Missense_Mutation_p.R213Q	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	303			R -> W (in ADHD7; has severely reduced solubility and is completely inactive; loss of function may lead to a reduced serotonin synthesis which in turn makes the mutation carriers susceptible to ADHD and possibly other psychiatric disorders).		aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	CAGTACATCCGGCATGGCTCA	0.542												
PPFIA2	8499	broad.mit.edu	37	12	81768413	81768413	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr12:81768413C>T	uc001szo.1	-	11	1427	c.1266G>A	c.(1264-1266)AAG>AAA	p.K422K	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	348										ovary(3)|lung(2)|pancreas(1)	6						AGTGCAGTACCTTGGTTAGGG	0.398												
RNF17	56163	broad.mit.edu	37	13	25440297	25440297	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr13:25440297C>T	uc001upr.2	+	30	4158	c.4117C>T	c.(4117-4119)CAT>TAT	p.H1373Y	RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.H1369Y|RNF17_uc001ups.2_Missense_Mutation_p.H1312Y|RNF17_uc010aac.2_Missense_Mutation_p.H565Y|RNF17_uc010aad.2_Missense_Mutation_p.H383Y	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1373					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AAGATCAGATCATGATAAAAA	0.313												
ATP8A2	51761	broad.mit.edu	37	13	26343356	26343356	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr13:26343356G>A	uc001uqk.2	+	26	2699	c.2557G>A	c.(2557-2559)GCC>ACC	p.A853T	ATP8A2_uc010tdi.1_Missense_Mutation_p.A813T|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.A403T	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	813	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		CTCGGATTACGCCATCGCACA	0.587												
WASF3	10810	broad.mit.edu	37	13	27216523	27216523	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr13:27216523G>T	uc001uqv.2	+	3	341	c.116G>T	c.(115-117)CGC>CTC	p.R39L	WASF3_uc001uqw.2_Missense_Mutation_p.R39L	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	39					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		GCTATCATACGCCAGCTGAGC	0.423												
LCP1	3936	broad.mit.edu	37	13	46718575	46718575	+	Splice_Site	SNP	A	A	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr13:46718575A>T	uc001vaz.3	-	11	1379	c.1253_splice	c.e11+1	p.S418_splice	LCP1_uc010ack.2_5'Flank|LCP1_uc001vay.3_Intron|LCP1_uc001vba.3_Splice_Site_p.S418_splice	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin						regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		AAATATTCCTACCTGTACAAA	0.418			T	BCL6	NHL 							
PCDH8	5100	broad.mit.edu	37	13	53421450	53421450	+	Silent	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr13:53421450G>A	uc001vhi.2	-	1	1325	c.1122C>T	c.(1120-1122)GCC>GCT	p.A374A	PCDH8_uc001vhj.2_Silent_p.A374A	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	374	Extracellular (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CAGCGGCGGCGGCGGCAGCGG	0.761												
CDH24	64403	broad.mit.edu	37	14	23518308	23518308	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr14:23518308C>T	uc001wil.2	-	12	2148	c.1888G>A	c.(1888-1890)GCT>ACT	p.A630T	CDH24_uc001wik.3_RNA|CDH24_uc010akf.2_Missense_Mutation_p.A592T	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	630	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		GAGAGGTGAGCCTCAGGCCAG	0.647												
NPAS3	64067	broad.mit.edu	37	14	34270262	34270262	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr14:34270262G>A	uc001wru.2	+	12	2813	c.2749G>A	c.(2749-2751)GTC>ATC	p.V917I	NPAS3_uc001wrs.2_Missense_Mutation_p.V904I|NPAS3_uc001wrt.2_Missense_Mutation_p.V885I|NPAS3_uc001wrv.2_Missense_Mutation_p.V887I	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	917					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		GCCCTTCCCCGTCTACAGCAA	0.697												
EML5	161436	broad.mit.edu	37	14	89130844	89130844	+	Silent	SNP	A	A	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr14:89130844A>G	uc001xxg.2	-	24	3588	c.3402T>C	c.(3400-3402)GAT>GAC	p.D1134D	EML5_uc001xxf.2_5'UTR|EML5_uc001xxh.1_Silent_p.D273D	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1134						cytoplasm|microtubule				ovary(3)	3						TACCTCTAATATCCCAATCAA	0.308												
SMEK1	55671	broad.mit.edu	37	14	91937312	91937312	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr14:91937312G>A	uc001xzn.2	-	10	2351	c.1529C>T	c.(1528-1530)GCA>GTA	p.A510V	SMEK1_uc001xzm.2_Missense_Mutation_p.A497V|SMEK1_uc001xzo.2_Missense_Mutation_p.A497V|SMEK1_uc010atz.2_Missense_Mutation_p.A271V|SMEK1_uc001xzp.1_RNA	NM_032560	NP_115949	Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1	510						microtubule organizing center|nucleus	protein binding				0		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		CAATACAAGTGCCAATAGTTG	0.318												
KIAA1409	57578	broad.mit.edu	37	14	94063796	94063796	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr14:94063796C>T	uc001ybv.1	+	21	2834	c.2751C>T	c.(2749-2751)TGC>TGT	p.C917C	KIAA1409_uc001ybs.1_Silent_p.C917C	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1094						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		ATGCCTTCTGCTGCTTCCTGA	0.493												
RYR3	6263	broad.mit.edu	37	15	33936587	33936587	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr15:33936587A>G	uc001zhi.2	+	28	3702	c.3632A>G	c.(3631-3633)AAG>AGG	p.K1211R	RYR3_uc010bar.2_Missense_Mutation_p.K1211R	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1211	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGTACCTTCAAGTTTTATACC	0.517												
DMXL2	23312	broad.mit.edu	37	15	51763453	51763453	+	Silent	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr15:51763453G>A	uc002abf.2	-	29	7581	c.7356C>T	c.(7354-7356)CCC>CCT	p.P2452P	DMXL2_uc002abd.2_Silent_p.P523P|DMXL2_uc010ufy.1_Silent_p.P2453P|DMXL2_uc010bfa.2_Silent_p.P1816P	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2452						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TACTAAGTTCGGGAGGAATAA	0.408												
SNX1	6642	broad.mit.edu	37	15	64422454	64422454	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr15:64422454G>C	uc002amv.2	+	10	985	c.949G>C	c.(949-951)GAG>CAG	p.E317Q	SNX1_uc010bgv.2_Missense_Mutation_p.E31Q|SNX1_uc010uio.1_Missense_Mutation_p.E317Q|SNX1_uc002amw.2_Missense_Mutation_p.E317Q|SNX1_uc002amx.2_Missense_Mutation_p.E252Q|SNX1_uc002amy.2_Missense_Mutation_p.E246Q|SNX1_uc010bgw.2_Missense_Mutation_p.E219Q	NM_003099	NP_003090	Q13596	SNX1_HUMAN	sorting nexin 1 isoform a	317	BAR.				cell communication|early endosome to Golgi transport|endocytosis|intracellular protein transport	early endosome membrane|Golgi apparatus	phosphatidylinositol binding|protein binding|protein transporter activity				0						CCAGGAGGTAGAGTGTGAGGA	0.448												
RASGRF1	5923	broad.mit.edu	37	15	79339211	79339211	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr15:79339211T>G	uc002beq.2	-	5	1130	c.755A>C	c.(754-756)GAG>GCG	p.E252A	RASGRF1_uc002bep.2_Missense_Mutation_p.E252A|RASGRF1_uc010blm.1_Missense_Mutation_p.E174A|RASGRF1_uc002ber.3_Missense_Mutation_p.E252A	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	252	DH.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						GTACTCAGCCTCAGCCTCCAG	0.597												
CPEB1	64506	broad.mit.edu	37	15	83218272	83218272	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr15:83218272T>G	uc002bit.2	-	9	1669	c.1532A>C	c.(1531-1533)AAC>ACC	p.N511T	CPEB1_uc002biq.2_Missense_Mutation_p.N371T|CPEB1_uc002bir.2_Missense_Mutation_p.N376T|CPEB1_uc002bis.2_Missense_Mutation_p.N371T|CPEB1_uc010uod.1_Missense_Mutation_p.N220T|CPEB1_uc010uoe.1_Missense_Mutation_p.N449T|CPEB1_uc002biu.2_Missense_Mutation_p.N473T|CPEB1_uc010uof.1_Missense_Mutation_p.N371T|CPEB1_uc002biv.2_Missense_Mutation_p.N446T|CPEB1_uc002bip.2_Missense_Mutation_p.N220T	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	451	RRM 2.|Necessary for stress granule assembly and correct localization in dcp1 bodies.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			AAATAGGTCGTTCAAGATGGC	0.532												
MAN2A2	4122	broad.mit.edu	37	15	91459446	91459446	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr15:91459446G>A	uc010bnz.2	+	20	3069	c.2954G>A	c.(2953-2955)CGT>CAT	p.R985H	MAN2A2_uc002bqc.2_Missense_Mutation_p.R985H|MAN2A2_uc010uql.1_Missense_Mutation_p.R647H|MAN2A2_uc010uqm.1_Missense_Mutation_p.R564H|MAN2A2_uc010uqn.1_RNA	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	985					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			ACCTGCAACCGTTTCCGCCTC	0.652												
MSLN	10232	broad.mit.edu	37	16	817420	817420	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr16:817420G>A	uc002cjw.1	+	15	1621	c.1570G>A	c.(1570-1572)GTG>ATG	p.V524M	MSLN_uc002cjt.1_Missense_Mutation_p.V516M|MSLN_uc002cju.1_Missense_Mutation_p.V516M|MSLN_uc010brd.1_Missense_Mutation_p.V515M|MSLN_uc002cjv.1_Missense_Mutation_p.V516M|MSLN_uc002cjx.1_Missense_Mutation_p.V516M|MSLN_uc002cjy.1_Missense_Mutation_p.V181M|MIR662_hsa-mir-662|MI0003670_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	524					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				TCAGCAGAATGTGAGCATGGA	0.532												
A2BP1	54715	broad.mit.edu	37	16	7568167	7568167	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr16:7568167G>A	uc002cys.2	+	5	1034	c.46G>A	c.(46-48)GCT>ACT	p.A16T	A2BP1_uc010buf.1_Missense_Mutation_p.A16T|A2BP1_uc002cyr.1_Missense_Mutation_p.A16T|A2BP1_uc002cyt.2_Missense_Mutation_p.A16T|A2BP1_uc010uxz.1_Missense_Mutation_p.A59T|A2BP1_uc010uya.1_Missense_Mutation_p.A52T|A2BP1_uc002cyv.1_Missense_Mutation_p.A16T|A2BP1_uc010uyb.1_Missense_Mutation_p.A16T|A2BP1_uc002cyw.2_Missense_Mutation_p.A36T|A2BP1_uc002cyy.2_Missense_Mutation_p.A36T|A2BP1_uc002cyx.2_Missense_Mutation_p.A36T|A2BP1_uc010uyc.1_Missense_Mutation_p.A36T	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	16					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		GGAAGCAGCCGCTGCCCCTGA	0.592												
SMG1	23049	broad.mit.edu	37	16	18883833	18883833	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr16:18883833C>T	uc002dfm.2	-	14	2367	c.2004G>A	c.(2002-2004)TTG>TTA	p.L668L	SMG1_uc010bwb.2_Silent_p.L528L	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	668	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						AATGAGAATACAATGTGTAGA	0.358												
ZNF423	23090	broad.mit.edu	37	16	49671081	49671081	+	Missense_Mutation	SNP	T	T	G	rs145272522	by1000genomes	TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr16:49671081T>G	uc002efs.2	-	5	2280	c.1982A>C	c.(1981-1983)AAG>ACG	p.K661T	ZNF423_uc010vgn.1_Missense_Mutation_p.K544T	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	661					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GCACGCTTGCTTCCGCAGCAG	0.557												
SNX20	124460	broad.mit.edu	37	16	50709712	50709712	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr16:50709712C>G	uc002egk.2	-	3	424	c.251G>C	c.(250-252)CGC>CCC	p.R84P	SNX20_uc010vgp.1_Missense_Mutation_p.R84P|SNX20_uc002egi.3_Missense_Mutation_p.R84P	NM_182854	NP_878274	Q7Z614	SNX20_HUMAN	sorting nexin 20 isoform 1	84	PX.				cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			ovary(1)	1						CTCCTCGATGCGAGCTGAAGC	0.413												
MMP2	4313	broad.mit.edu	37	16	55519277	55519277	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr16:55519277C>T	uc002ehz.3	+	4	907	c.596C>T	c.(595-597)ACT>ATT	p.T199I	MMP2_uc010vhd.1_Missense_Mutation_p.T123I|MMP2_uc010ccc.2_Missense_Mutation_p.T149I	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	199	Collagenase-like 1.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	GCCCCAGGCACTGGTGTTGGG	0.567												
CDH3	1001	broad.mit.edu	37	16	68718510	68718510	+	Nonsense_Mutation	SNP	C	C	T	rs143523495	by1000genomes	TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr16:68718510C>T	uc002ewf.2	+	10	2339	c.1207C>T	c.(1207-1209)CAG>TAG	p.Q403*	CDH3_uc010vli.1_Nonsense_Mutation_p.Q348*	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	403	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		GGCCAAAAACCAGCACACCCT	0.522												
BCMO1	53630	broad.mit.edu	37	16	81298282	81298282	+	Missense_Mutation	SNP	C	C	T	rs119478057	byFrequency	TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr16:81298282C>T	uc002fgn.1	+	5	727	c.509C>T	c.(508-510)ACG>ATG	p.T170M	BCMO1_uc010vnp.1_Missense_Mutation_p.T101M	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	170			T -> M (in ADHVAD; has about 90% decreased enzyme activity compared to wild-type; no evidence for a dominant- negative effect; consistent with a loss- of-function mutation resulting in haploinsufficiency).		retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						AATCTGGCAACGTCACATCCC	0.403												
JPH3	57338	broad.mit.edu	37	16	87678559	87678559	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr16:87678559C>T	uc002fkd.2	+	2	1332	c.1078C>T	c.(1078-1080)CGC>TGC	p.R360C	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	360	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CAGCAAGATCCGCGAGAAGGT	0.672												
TP53	7157	broad.mit.edu	37	17	7578403	7578403	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr17:7578403C>A	uc002gim.2	-	5	721	c.527G>T	c.(526-528)TGC>TTC	p.C176F	TP53_uc002gig.1_Missense_Mutation_p.C176F|TP53_uc002gih.2_Missense_Mutation_p.C176F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C44F|TP53_uc010cng.1_Missense_Mutation_p.C44F|TP53_uc002gii.1_Missense_Mutation_p.C44F|TP53_uc010cnh.1_Missense_Mutation_p.C176F|TP53_uc010cni.1_Missense_Mutation_p.C176F|TP53_uc002gij.2_Missense_Mutation_p.C176F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C83F|TP53_uc002gio.2_Missense_Mutation_p.C44F|TP53_uc010vug.1_Missense_Mutation_p.C137F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	176	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	CP -> FS (in a sporadic cancer; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C176F(102)|p.C176Y(56)|p.C176S(19)|p.C176W(11)|p.C176R(8)|p.C176fs*71(7)|p.0?(7)|p.C176*(6)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.C176G(3)|p.C176fs*5(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176_P177delCP(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.C44Y(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R42fs*24(1)|p.C83Y(1)|p.C176fs*72(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.C176del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.C176fs*6(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGTGGGGGCAGCGCCTCAC	0.652		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
EVI2B	2124	broad.mit.edu	37	17	29631447	29631447	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr17:29631447G>T	uc002hgk.2	-	2	1336	c.1181C>A	c.(1180-1182)TCA>TAA	p.S394*	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Nonsense_Mutation_p.S409*	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	394	Cytoplasmic (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		CGGTGGAAATGATTGTATTAT	0.413												
C17orf98	388381	broad.mit.edu	37	17	36991500	36991500	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr17:36991500G>A	uc002hqv.2	-	3	407	c.407C>T	c.(406-408)CCA>CTA	p.P136L		NM_001080465	NP_001073934	A8MV24	CQ098_HUMAN	hypothetical protein LOC388381	136											0						ACGGAGGGCTGGAGTGTTCCT	0.527												
RUNDC1	146923	broad.mit.edu	37	17	41143004	41143004	+	Silent	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr17:41143004G>A	uc002ici.1	+	5	1125	c.1113G>A	c.(1111-1113)AGG>AGA	p.R371R	RUNDC1_uc010whi.1_Silent_p.R141R	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	371											0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		TGTGGCAGAGGGTCCAGGCTG	0.597												
FZD2	2535	broad.mit.edu	37	17	42636499	42636499	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr17:42636499C>T	uc002igx.1	+	1	1575	c.1443C>T	c.(1441-1443)TTC>TTT	p.F481F		NM_001466	NP_001457	Q14332	FZD2_HUMAN	frizzled 2 precursor	481	Helical; Name=6; (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CTTGCTACTTCTACGAGCAGG	0.647												
NFE2L1	4779	broad.mit.edu	37	17	46128574	46128574	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr17:46128574C>T	uc002imz.3	+	2	745	c.94C>T	c.(94-96)CTG>TTG	p.L32L	NFE2L1_uc002ina.3_Silent_p.L32L|NFE2L1_uc002inb.3_Silent_p.L32L|NFE2L1_uc002inc.1_Silent_p.L32L	NM_003204	NP_003195	Q14494	NF2L1_HUMAN	nuclear factor erythroid 2-like 1	32					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1						GGATACTTACCTGACCTCACA	0.507												
BZRAP1	9256	broad.mit.edu	37	17	56386420	56386420	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr17:56386420G>A	uc002ivx.3	-	22	5084	c.4213C>T	c.(4213-4215)CGG>TGG	p.R1405W	BZRAP1_uc002ivw.2_5'Flank|BZRAP1_uc010dcs.2_Missense_Mutation_p.R1345W|BZRAP1_uc010wnt.1_Missense_Mutation_p.R1405W	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1405						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCTCTCCTCCGGCTGCTTCCA	0.637												
BZRAP1	9256	broad.mit.edu	37	17	56396519	56396519	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr17:56396519A>G	uc002ivx.3	-	13	2502	c.1631T>C	c.(1630-1632)CTT>CCT	p.L544P	BZRAP1_uc010dcs.2_Missense_Mutation_p.L484P|BZRAP1_uc010wnt.1_Missense_Mutation_p.L544P	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	544						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCAGTCTCCAAGGCTCCCACA	0.647												
RGS9	8787	broad.mit.edu	37	17	63200369	63200369	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr17:63200369C>T	uc002jfe.2	+	15	1263	c.1153C>T	c.(1153-1155)CGC>TGC	p.R385C	RGS9_uc010dem.2_Missense_Mutation_p.R382C|RGS9_uc002jfd.2_Missense_Mutation_p.R382C|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Missense_Mutation_p.R156C	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	385	RGS.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						GCACCCCCACCGCTATGTGCT	0.587												
AXIN2	8313	broad.mit.edu	37	17	63532604	63532604	+	Missense_Mutation	SNP	G	G	A	rs142670753		TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr17:63532604G>A	uc002jfi.2	-	8	2264	c.1975C>T	c.(1975-1977)CGG>TGG	p.R659W	AXIN2_uc002jfh.2_Missense_Mutation_p.R594W	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	659					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						AGATGGTGCCGGCTGGCTCGT	0.632									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome			
GPRC5C	55890	broad.mit.edu	37	17	72428204	72428204	+	Silent	SNP	A	A	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr17:72428204A>G	uc002jkp.2	+	1	538	c.27A>G	c.(25-27)CAA>CAG	p.Q9Q	GPRC5C_uc002jkq.2_Silent_p.Q9Q|GPRC5C_uc002jkr.2_5'Flank	NM_022036	NP_071319	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor family C, group 5,	Error:Variant_position_missing_in_Q9NQ84_after_alignment						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			ovary(2)|prostate(1)|central_nervous_system(1)|pancreas(1)	5						GTCAACAGCAACAACCCACAC	0.682												
SLC14A2	8170	broad.mit.edu	37	18	43262407	43262407	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr18:43262407C>T	uc010dnj.2	+	21	3007	c.2686C>T	c.(2686-2688)CGC>TGC	p.R896C	SLC14A2_uc002lbe.2_Missense_Mutation_p.R896C	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	896						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						AGAGGCCAACCGCATCTACTA	0.512												
DCC	1630	broad.mit.edu	37	18	50994343	50994343	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr18:50994343G>T	uc002lfe.1	+	25	4286	c.3699G>T	c.(3697-3699)AAG>AAT	p.K1233N	DCC_uc010dpf.1_Missense_Mutation_p.K868N	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1233	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CCCGGGCCAAGCTCATGATTC	0.488												
MUC16	94025	broad.mit.edu	37	19	9010994	9010994	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:9010994C>T	uc002mkp.2	-	37	39128	c.38924G>A	c.(38923-38925)CGG>CAG	p.R12975Q	MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CACAGAGCTCCGATGGGTGAA	0.532												
MUC16	94025	broad.mit.edu	37	19	9073053	9073053	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:9073053G>A	uc002mkp.2	-	3	14597	c.14393C>T	c.(14392-14394)ACC>ATC	p.T4798I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4800	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGTGAACTGGTCACTGTTTC	0.453												
MUC16	94025	broad.mit.edu	37	19	9076960	9076960	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:9076960C>G	uc002mkp.2	-	3	10690	c.10486G>C	c.(10486-10488)GAG>CAG	p.E3496Q		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3497	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTCAGAGTCTCAAGCCCTATT	0.512												
TRMT1	55621	broad.mit.edu	37	19	13226181	13226181	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:13226181C>T	uc002mwj.2	-	4	803	c.553G>A	c.(553-555)GCC>ACC	p.A185T	NACC1_uc002mwm.2_5'Flank|TRMT1_uc002mwk.2_Missense_Mutation_p.A185T|TRMT1_uc002mwl.3_Missense_Mutation_p.A185T|TRMT1_uc010xmz.1_5'UTR	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	185							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		CGGGTGGAGGCATCGTTTGCA	0.602												
ZNF430	80264	broad.mit.edu	37	19	21240536	21240536	+	Silent	SNP	A	A	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:21240536A>T	uc002npj.2	+	5	1532	c.1422A>T	c.(1420-1422)GCA>GCT	p.A474A	ZNF430_uc002npk.2_Silent_p.A473A	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	474	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						AACTTACTGCACATAAGGTAA	0.373												
ANKRD27	84079	broad.mit.edu	37	19	33106644	33106644	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:33106644C>A	uc002ntn.1	-	22	2251	c.2095G>T	c.(2095-2097)GCG>TCG	p.A699S		NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	699					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					GTGTCCTCCGCATCCTCCAGG	0.547												
CEBPG	1054	broad.mit.edu	37	19	33870289	33870289	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:33870289C>T	uc002nup.2	+	2	433	c.144C>T	c.(142-144)CCC>CCT	p.P48P		NM_001806	NP_001797	P53567	CEBPG_HUMAN	CCAAT/enhancer binding protein gamma	48					B cell differentiation|enucleate erythrocyte differentiation|liver development|natural killer cell mediated cytotoxicity|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of DNA binding|positive regulation of DNA repair|positive regulation of interferon-gamma biosynthetic process|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0	Esophageal squamous(110;0.137)					CTGTGGCTCCCAGCAAGCAGA	0.557												
ZNF566	84924	broad.mit.edu	37	19	36940522	36940522	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:36940522C>A	uc002oea.3	-	5	696	c.614G>T	c.(613-615)GGA>GTA	p.G205V	ZNF566_uc010xte.1_Missense_Mutation_p.G205V|ZNF566_uc010xtf.1_Missense_Mutation_p.G206V|ZNF566_uc002oeb.3_Missense_Mutation_p.G205V|ZNF566_uc002oec.3_Missense_Mutation_p.G101V|ZNF566_uc010xtg.1_Missense_Mutation_p.G101V	NM_032838	NP_116227	Q969W8	ZN566_HUMAN	zinc finger protein 566 isoform 1	205	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					AAAGGACTTTCCACATTCCTT	0.363												
B9D2	80776	broad.mit.edu	37	19	41863923	41863923	+	Silent	SNP	C	C	T	rs142424836	by1000genomes	TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:41863923C>T	uc002oqj.2	-	3	313	c.93G>A	c.(91-93)GCG>GCA	p.A31A	CYP2F1_uc010xvw.1_Intron|TMEM91_uc002oqi.2_Intron	NM_030578	NP_085055	Q9BPU9	B9D2_HUMAN	B9 protein domain 2	31	B9.				cilium assembly|mitotic prometaphase	centrosome|cilium axoneme|cytosol|microtubule basal body|nucleus	gamma-tubulin binding			ovary(1)	1						GCTTCCATGCCGCCCCTGCAG	0.627												
GPR77	27202	broad.mit.edu	37	19	47844598	47844598	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:47844598C>T	uc010ela.1	+	2	760	c.542C>T	c.(541-543)CCA>CTA	p.P181L	GPR77_uc002pgk.1_Missense_Mutation_p.P181L	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	181	Extracellular (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		GAGCACTTCCCAGCCCGGCTG	0.677												
KPTN	11133	broad.mit.edu	37	19	47981013	47981013	+	Silent	SNP	A	A	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:47981013A>G	uc002pgy.2	-	9	917	c.813T>C	c.(811-813)GAT>GAC	p.D271D	KPTN_uc010xys.1_RNA	NM_007059	NP_008990	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	271					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			ovary(1)	1		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)		CGCTGTACTCATCTTGTAGTG	0.388												
SCAF1	58506	broad.mit.edu	37	19	50161535	50161535	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:50161535G>A	uc002poq.2	+	11	3942	c.3818G>A	c.(3817-3819)CGC>CAC	p.R1273H		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	1273	Necessary for interaction with the CTD domain of POLR2A.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		TACGTCCAGCGCTACCGCTAC	0.682												
ZNF320	162967	broad.mit.edu	37	19	53367302	53367302	+	RNA	SNP	C	C	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:53367302C>A	uc010eqh.1	-	3		c.375G>T			ZNF320_uc010eqi.1_RNA			A2RRD8	ZN320_HUMAN	Homo sapiens full length insert cDNA clone ZD42C02.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		ACTCCAGGTTCCTGTAGTTCT	0.458												
NLRP2	55655	broad.mit.edu	37	19	55494466	55494466	+	Missense_Mutation	SNP	G	G	A	rs147804224	byFrequency	TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:55494466G>A	uc002qij.2	+	6	1486	c.1400G>A	c.(1399-1401)CGA>CAA	p.R467Q	NLRP2_uc010yfp.1_Missense_Mutation_p.R444Q|NLRP2_uc010esn.2_Missense_Mutation_p.R443Q|NLRP2_uc010eso.2_Missense_Mutation_p.R464Q|NLRP2_uc010esp.2_Missense_Mutation_p.R445Q	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	467	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GTGCTTCACCGAGAGGATCTG	0.687												
NLRP13	126204	broad.mit.edu	37	19	56419255	56419255	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr19:56419255G>C	uc010ygg.1	-	7	2375	c.2350C>G	c.(2350-2352)CTG>GTG	p.L784V		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	784	LRR 2.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		AGATGGGTCAGCTTGCTGTTA	0.488												
ALK	238	broad.mit.edu	37	2	29462633	29462633	+	Silent	SNP	G	G	A	rs149853746	byFrequency	TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:29462633G>A	uc002rmy.2	-	13	3175	c.2268C>T	c.(2266-2268)GGC>GGT	p.G756G		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	756	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GCACAGACACGCCGTGGGACC	0.602			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome			
PRKCE	5581	broad.mit.edu	37	2	46411945	46411945	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:46411945C>T	uc002rut.2	+	15	2336	c.2139C>T	c.(2137-2139)GAC>GAT	p.D713D		NM_005400	NP_005391	Q02156	KPCE_HUMAN	protein kinase C, epsilon	713	AGC-kinase C-terminal.				activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity			lung(4)|ovary(3)|kidney(1)|breast(1)|large_intestine(1)	10		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			CCCTTGTGGACGAAGCAATTG	0.468												
SOCS5	9655	broad.mit.edu	37	2	46987047	46987047	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:46987047A>G	uc002rvf.2	+	2	1542	c.1378A>G	c.(1378-1380)AAA>GAA	p.K460E	SOCS5_uc010yoe.1_Missense_Mutation_p.K429E|SOCS5_uc002rvg.2_Missense_Mutation_p.K460E	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	460	SH2.				cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			AGAACATTATAAAGATCCCAG	0.433												
CTNNA2	1496	broad.mit.edu	37	2	80773040	80773040	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:80773040T>A	uc010ysh.1	+	10	1397	c.1392T>A	c.(1390-1392)AAT>AAA	p.N464K	CTNNA2_uc010yse.1_Missense_Mutation_p.N464K|CTNNA2_uc010ysf.1_Missense_Mutation_p.N464K|CTNNA2_uc010ysg.1_Missense_Mutation_p.N464K|CTNNA2_uc010ysi.1_Missense_Mutation_p.N96K	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	464					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AGGTCATCAATGCCGCTCTGA	0.498												
C2orf68	388969	broad.mit.edu	37	2	85839180	85839180	+	Splice_Site	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:85839180G>A	uc002sqc.2	-	1	1	c.-71_splice	c.e1-1		USP39_uc002sqb.2_Intron|USP39_uc010ysu.1_5'Flank|USP39_uc010ysv.1_5'Flank|C2orf68_uc002sqd.2_Splice_Site	NM_001013649	NP_001013671	Q2NKX9	CB068_HUMAN	hypothetical protein LOC388969											central_nervous_system(1)	1						AGAGCTCCGCGCCGCCCCTTG	0.736												
ADRA2B	151	broad.mit.edu	37	2	96780826	96780826	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:96780826G>A	uc002svi.2	-	3	1072	c.1072C>T	c.(1072-1074)CGT>TGT	p.R358C		NM_000682	NP_000673	P18089	ADA2B_HUMAN	alpha-2B-adrenergic receptor	358	Cytoplasmic (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			ovary(2)|lung(1)	3					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	GCCCGTCGACGCCACCACTGC	0.662												
MAP4K4	9448	broad.mit.edu	37	2	102460759	102460759	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:102460759C>T	uc002tbg.2	+	12	1274	c.1219C>T	c.(1219-1221)CGA>TGA	p.R407*	MAP4K4_uc002tbc.2_Nonsense_Mutation_p.R407*|MAP4K4_uc002tbd.2_Nonsense_Mutation_p.R407*|MAP4K4_uc002tbe.2_Nonsense_Mutation_p.R407*|MAP4K4_uc002tbf.2_Nonsense_Mutation_p.R407*|MAP4K4_uc010yvy.1_Nonsense_Mutation_p.R407*|MAP4K4_uc002tbh.2_Nonsense_Mutation_p.R407*|MAP4K4_uc002tbi.2_Nonsense_Mutation_p.R260*|MAP4K4_uc010yvz.1_Nonsense_Mutation_p.R387*|MAP4K4_uc002tbk.2_5'UTR|MAP4K4_uc002tbj.1_Nonsense_Mutation_p.R303*	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	407					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						AGAACAGAGGCGACGGCTAGA	0.468												
ZC3H6	376940	broad.mit.edu	37	2	113088794	113088794	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:113088794G>T	uc002thq.1	+	12	2693	c.2299G>T	c.(2299-2301)GAC>TAC	p.D767Y		NM_198581	NP_940983	P61129	ZC3H6_HUMAN	zinc finger CCCH-type domain containing 6	767							nucleic acid binding|zinc ion binding			ovary(3)|central_nervous_system(1)	4						CCCAAGGCAAGACATTAGAAA	0.473												
CCDC74B	91409	broad.mit.edu	37	2	130897230	130897230	+	Silent	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:130897230G>A	uc002tqm.1	-	8	1103	c.1041C>T	c.(1039-1041)GCC>GCT	p.A347A	CCDC74B_uc010yzw.1_Silent_p.A449A|CCDC74B_uc002tqn.1_Silent_p.A281A	NM_207310	NP_997193	Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	347											0	Colorectal(110;0.1)					CGGGCAGGATGGCACGCTCCG	0.642												
NCKAP5	344148	broad.mit.edu	37	2	133540023	133540023	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:133540023G>T	uc002ttp.2	-	14	4735	c.4361C>A	c.(4360-4362)GCC>GAC	p.A1454D	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1454							protein binding				0						GGTTGCAGAGGCATCTGGATG	0.517												
LCT	3938	broad.mit.edu	37	2	136566344	136566344	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:136566344C>A	uc002tuu.1	-	8	3584	c.3573G>T	c.(3571-3573)GAG>GAT	p.E1191D		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1191	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCTTCTCTTCCTCAGTGAAGC	0.532												
TANC1	85461	broad.mit.edu	37	2	160086925	160086925	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:160086925C>T	uc002uag.2	+	27	5262	c.4988C>T	c.(4987-4989)TCA>TTA	p.S1663L	TANC1_uc010zcm.1_3'UTR|TANC1_uc010fon.2_Missense_Mutation_p.S507L	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1663	Ser-rich.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						CTCACCAGCTCAGGCTCTTCT	0.552												
FAP	2191	broad.mit.edu	37	2	163029701	163029701	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:163029701A>T	uc002ucd.2	-	24	2273	c.2065T>A	c.(2065-2067)TTC>ATC	p.F689I	FAP_uc010fpc.2_Missense_Mutation_p.F238I|FAP_uc010zct.1_Missense_Mutation_p.F664I|FAP_uc010fpd.2_Missense_Mutation_p.F168I	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	689	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						ACATTTCTGAAATATTCTGCT	0.348												
TTN	7273	broad.mit.edu	37	2	179432952	179432952	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:179432952G>T	uc010zfg.1	-	275	70427	c.70203C>A	c.(70201-70203)AAC>AAA	p.N23401K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.N17096K|TTN_uc010zfi.1_Missense_Mutation_p.N17029K|TTN_uc010zfj.1_Missense_Mutation_p.N16904K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24328							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E23401K(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCCATATCTGTTTTCGGCAA	0.413												
TTN	7273	broad.mit.edu	37	2	179452058	179452058	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:179452058C>T	uc010zfg.1	-	256	56400	c.56176G>A	c.(56176-56178)GGT>AGT	p.G18726S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G12421S|TTN_uc010zfi.1_Missense_Mutation_p.G12354S|TTN_uc010zfj.1_Missense_Mutation_p.G12229S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19653							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGCTCCCACCGTCGTTTTCA	0.463												
TTN	7273	broad.mit.edu	37	2	179584366	179584366	+	Silent	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:179584366G>A	uc010zfg.1	-	79	20345	c.20121C>T	c.(20119-20121)GCC>GCT	p.A6707A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.A3368A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7634							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTCATTTCGGCACAGGGGA	0.403												
PPP1R1C	151242	broad.mit.edu	37	2	182852605	182852605	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:182852605C>A	uc002uoo.2	+	2	408	c.121C>A	c.(121-123)CTC>ATC	p.L41I	PPP1R1C_uc002uon.2_Intron|PPP1R1C_uc002uop.1_Missense_Mutation_p.L41I|PPP1R1C_uc010frm.1_Missense_Mutation_p.L48I|PPP1R1C_uc010frn.1_RNA	NM_001080545	NP_001074014	Q8WVI7	PPR1C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	41					signal transduction	cytoplasm	protein phosphatase inhibitor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0628)			ACTTGTGATTCTCAATGAGCA	0.413												
DNAH7	56171	broad.mit.edu	37	2	196729451	196729451	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:196729451G>T	uc002utj.3	-	41	7029	c.6928C>A	c.(6928-6930)CCC>ACC	p.P2310T		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2310	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGGTTCATGGGTTTTTTGCTT	0.433												
CXCR7	57007	broad.mit.edu	37	2	237489880	237489880	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:237489880G>A	uc010fyq.2	+	3	1002	c.772G>A	c.(772-774)GTG>ATG	p.V258M	CXCR7_uc002vwd.2_Missense_Mutation_p.V258M	NM_020311	NP_064707	P25106	CXCR7_HUMAN	chemokine orphan receptor 1	258	Helical; Name=6; (Potential).				interspecies interaction between organisms	integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3		Breast(86;0.000182)|Renal(207;0.00339)|all_hematologic(139;0.0048)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|all_lung(227;0.147)|all_neural(83;0.223)		Epithelial(121;8.35e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.09e-11)|Kidney(56;1.11e-07)|KIRC - Kidney renal clear cell carcinoma(57;3.03e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000176)|Lung(119;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.118)		CTTCTCCTACGTGGTGGTCTT	0.577												
RBM44	375316	broad.mit.edu	37	2	238726967	238726967	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:238726967G>A	uc002vxi.3	+	3	1540	c.1408G>A	c.(1408-1410)GAC>AAC	p.D470N		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	469							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		TCAGACAGTGGACGTTAGCAC	0.393												
PER2	8864	broad.mit.edu	37	2	239161666	239161666	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr2:239161666G>A	uc002vyc.2	-	19	3235	c.2998C>T	c.(2998-3000)CCT>TCT	p.P1000S	PER2_uc010znv.1_Missense_Mutation_p.P1000S	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	1000					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		CCACCCTCAGGGGCTTCCTCC	0.672												
FAM110A	83541	broad.mit.edu	37	20	825521	825521	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr20:825521C>T	uc002wef.1	+	2	410	c.74C>T	c.(73-75)CCT>CTT	p.P25L	FAM110A_uc002weg.1_Missense_Mutation_p.P25L|FAM110A_uc002weh.1_Missense_Mutation_p.P25L|FAM110A_uc010fzz.2_5'Flank	NM_001042353	NP_001035812	Q9BQ89	F110A_HUMAN	hypothetical protein LOC83541	25						microtubule organizing center|spindle pole	protein binding				0						ACCAGGGTCCCTGGCTACCTG	0.692												
SLC4A11	83959	broad.mit.edu	37	20	3218214	3218214	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr20:3218214G>A	uc002wig.2	-	1	160	c.112C>T	c.(112-114)CAG>TAG	p.Q38*	SLC4A11_uc010zqe.1_Nonsense_Mutation_p.Q65*|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Nonsense_Mutation_p.Q22*	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	38	Cytoplasmic (Potential).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						TATCCATTCTGCGACATGGTG	0.587												
SMOX	54498	broad.mit.edu	37	20	4163097	4163097	+	Missense_Mutation	SNP	C	C	T	rs138153642		TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr20:4163097C>T	uc002wkm.1	+	5	1172	c.971C>T	c.(970-972)CCG>CTG	p.P324L	SMOX_uc002wkk.1_Intron|SMOX_uc002wkl.1_Intron|SMOX_uc002wkn.1_Intron|SMOX_uc002wkp.2_Missense_Mutation_p.P324L|SMOX_uc010zqo.1_Intron|SMOX_uc002wko.1_Missense_Mutation_p.P324L	NM_175839	NP_787033	Q9NWM0	SMOX_HUMAN	spermine oxidase isoform 1	324					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)	1					Spermine(DB00127)	GAGCTGATCCCGGCGGACCAT	0.642												
CST2	1470	broad.mit.edu	37	20	23805914	23805914	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr20:23805914G>T	uc002wtq.1	-	2	290	c.275C>A	c.(274-276)ACC>AAC	p.T92N		NM_001322	NP_001313	P09228	CYTT_HUMAN	cystatin SA precursor	92						extracellular region	cysteine-type endopeptidase inhibitor activity				0						GGTACATATGGTTCGGCCCAC	0.547												
TSHZ2	128553	broad.mit.edu	37	20	51871962	51871962	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr20:51871962G>T	uc002xwo.2	+	2	2921	c.1965G>T	c.(1963-1965)GAG>GAT	p.E655D		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	655					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AGGAGGAGGAGAAGCTGATGA	0.597												
BRWD1	54014	broad.mit.edu	37	21	40627657	40627657	+	Silent	SNP	A	A	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr21:40627657A>G	uc002yxk.1	-	19	2308	c.2169T>C	c.(2167-2169)GCT>GCC	p.A723A	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Silent_p.A723A|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_Silent_p.A176A|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_Intron|BRWD1_uc010goi.1_Silent_p.A443A	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	723					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GACTGCGTGGAGCGTTTTGAT	0.463												
TBC1D10A	83874	broad.mit.edu	37	22	30689913	30689913	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr22:30689913C>A	uc011akt.1	-	7	916	c.892G>T	c.(892-894)GAA>TAA	p.E298*	GATSL3_uc003ahf.2_RNA|GATSL3_uc003ahg.2_RNA|GATSL3_uc003ahh.2_RNA|GATSL3_uc010gvq.2_RNA|GATSL3_uc003ahi.2_Nonsense_Mutation_p.E156*|TBC1D10A_uc003ahj.3_Nonsense_Mutation_p.E210*|TBC1D10A_uc010gvu.2_Nonsense_Mutation_p.E305*|TBC1D10A_uc003ahk.3_Nonsense_Mutation_p.E298*	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	298	Rab-GAP TBC.					intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CCAGTACCTTCACAGAAGAAC	0.572												
PANX2	56666	broad.mit.edu	37	22	50615660	50615660	+	Silent	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr22:50615660G>A	uc003bjn.3	+	2	519	c.519G>A	c.(517-519)GCG>GCA	p.A173A	PANX2_uc003bjp.3_Silent_p.A39A|PANX2_uc003bjo.3_Silent_p.A173A	NM_052839	NP_443071	Q96RD6	PANX2_HUMAN	pannexin 2 isoform 1	173	Cytoplasmic (Potential).				protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)	1		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		AGGGCCGCGCGCCCAAGATCG	0.657												
SATB1	6304	broad.mit.edu	37	3	18435984	18435984	+	Silent	SNP	T	T	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:18435984T>C	uc003cbh.2	-	7	2911	c.1176A>G	c.(1174-1176)GTA>GTG	p.V392V	SATB1_uc003cbi.2_Silent_p.V392V|SATB1_uc003cbj.2_Silent_p.V392V	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	392	CUT 1.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						CACGTGCAAATACCGCCTGGG	0.458												
CLEC3B	7123	broad.mit.edu	37	3	45077363	45077363	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:45077363G>A	uc003cok.3	+	3	652	c.556G>A	c.(556-558)GAC>AAC	p.D186N	CLEC3B_uc003col.2_Missense_Mutation_p.D144N	NM_003278	NP_003269	P05452	TETN_HUMAN	C-type lectin domain family 3, member B	186	C-type lectin.				skeletal system development	extracellular space	protein binding|sugar binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00863)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAGTGGTTCGACAAGCGCTG	0.557												
LAMB2	3913	broad.mit.edu	37	3	49166009	49166009	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:49166009G>T	uc003cwe.2	-	15	2199	c.1900C>A	c.(1900-1902)CAA>AAA	p.Q634K	LAMB2_uc003cwf.1_Missense_Mutation_p.Q634K	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	634	Laminin IV type B.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCTGCCCATTGCTCAGGGACC	0.582												
UBA7	7318	broad.mit.edu	37	3	49847040	49847040	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:49847040C>G	uc003cxr.2	-	16	2194	c.2023G>C	c.(2023-2025)GGC>CGC	p.G675R		NM_003335	NP_003326	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	675					ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TTCCAGTGGCCAAGAGCCCAC	0.552												
GRM2	2912	broad.mit.edu	37	3	51749696	51749696	+	Missense_Mutation	SNP	G	G	A	rs150657954	byFrequency	TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:51749696G>A	uc010hlv.2	+	4	2146	c.1907G>A	c.(1906-1908)CGT>CAT	p.R636H	GRM2_uc003dbo.3_Missense_Mutation_p.R18H|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	636	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	ACCTTACGGCGTCTTGGTTTG	0.592												
ADAMTS9	56999	broad.mit.edu	37	3	64582545	64582545	+	Silent	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:64582545G>A	uc003dmg.2	-	27	4172	c.4140C>T	c.(4138-4140)TCC>TCT	p.S1380S	ADAMTS9_uc011bfo.1_Silent_p.S1352S|ADAMTS9_uc003dmh.1_Silent_p.S1209S|ADAMTS9_uc011bfp.1_Silent_p.S291S	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1380					glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GACAAGGGCCGGATTCACAGG	0.463												
FRMD4B	23150	broad.mit.edu	37	3	69231783	69231783	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:69231783G>C	uc003dnv.2	-	20	2295	c.2005C>G	c.(2005-2007)CTT>GTT	p.L669V	FRMD4B_uc003dnw.2_Intron|FRMD4B_uc003dnu.2_Missense_Mutation_p.L321V|FRMD4B_uc011bga.1_Missense_Mutation_p.L513V	NM_015123	NP_055938	Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	669						cytoplasm|cytoskeleton	binding			ovary(3)|central_nervous_system(1)	4		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		TTTCGGGTAAGAACTGGCGTG	0.493												
FAM55C	91775	broad.mit.edu	37	3	101540691	101540691	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:101540691G>A	uc003dvn.2	+	8	2210	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K	FAM55C_uc010hpn.2_Missense_Mutation_p.E525K	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	525						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						CGATGCCTGGGAGATGACCCT	0.507												
BBX	56987	broad.mit.edu	37	3	107435518	107435518	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:107435518C>T	uc010hpr.2	+	5	554	c.227C>T	c.(226-228)CCA>CTA	p.P76L	BBX_uc003dwk.3_Missense_Mutation_p.P76L|BBX_uc003dwl.3_Missense_Mutation_p.P76L|BBX_uc010hps.1_Missense_Mutation_p.P97L|BBX_uc003dwm.3_Missense_Mutation_p.P76L	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	76					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GATGAATCACCAGAGCAGCGA	0.463												
GP9	2815	broad.mit.edu	37	3	128780765	128780765	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:128780765C>G	uc003elm.2	+	3	370	c.183C>G	c.(181-183)AAC>AAG	p.N61K		NM_000174	NP_000165	P14770	GPIX_HUMAN	glycoprotein IX (platelet) precursor	61	Extracellular (Potential).|LRR.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding				0					Quinine(DB00468)	TGGCCAACAACAGCCTTCAGT	0.682												
PRR23B	389151	broad.mit.edu	37	3	138739150	138739150	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:138739150C>T	uc003esy.1	-	1	619	c.354G>A	c.(352-354)TCG>TCA	p.S118S		NM_001013650	NP_001013672	Q6ZRT6	PR23B_HUMAN	proline rich 23B	118										breast(1)	1						GCCCGGCAGACGAGTCGTGCT	0.637												
MME	4311	broad.mit.edu	37	3	154886304	154886304	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:154886304G>C	uc010hvr.1	+	19	2015	c.1804G>C	c.(1804-1806)GAC>CAC	p.D602H	MME_uc003fab.1_Missense_Mutation_p.D602H|MME_uc003fac.1_Missense_Mutation_p.D602H|MME_uc003fad.1_Missense_Mutation_p.D602H|MME_uc003fae.1_Missense_Mutation_p.D602H	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	602	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CAAAGATGGAGACCTCGTTGA	0.378												
FNDC3B	64778	broad.mit.edu	37	3	171965381	171965381	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:171965381G>A	uc003fhy.2	+	5	495	c.323G>A	c.(322-324)TGT>TAT	p.C108Y	FNDC3B_uc003fhz.3_Missense_Mutation_p.C108Y|FNDC3B_uc003fia.2_Missense_Mutation_p.C39Y	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	108						endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TCTCCTGAGTGTTATCCCCCA	0.483												
EIF4A2	1974	broad.mit.edu	37	3	186503790	186503790	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr3:186503790T>A	uc003fqs.2	+	5	506	c.467T>A	c.(466-468)GTT>GAT	p.V156D	EIF4A2_uc003fqt.2_RNA|EIF4A2_uc003fqu.2_Missense_Mutation_p.V157D|EIF4A2_uc003fqv.2_Missense_Mutation_p.V61D|EIF4A2_uc003fqw.2_Missense_Mutation_p.V61D|EIF4A2_uc011bsb.1_Missense_Mutation_p.V29D|MIR1248_hsa-mir-1248|MI0006383_5'Flank|SNORA81_uc010hyv.1_5'Flank|SNORA63_uc010hyw.1_5'Flank|SNORA4_uc010hyx.1_5'Flank	NM_001967	NP_001958	Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	156	Helicase ATP-binding.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			ovary(2)|breast(2)	4	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		CCACATATTGTTGTTGGTACA	0.378			T	BCL6	NHL							
PRDM5	11107	broad.mit.edu	37	4	121739673	121739673	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr4:121739673C>G	uc003idn.2	-	5	735	c.485G>C	c.(484-486)GGC>GCC	p.G162A	PRDM5_uc003ido.2_Missense_Mutation_p.G162A|PRDM5_uc010ine.2_Missense_Mutation_p.G162A|PRDM5_uc010inf.2_Missense_Mutation_p.G162A	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	162					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						CTCTTTACAGCCAAGGCGATC	0.388												
FAT4	79633	broad.mit.edu	37	4	126242374	126242374	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr4:126242374C>A	uc003ifj.3	+	1	4808	c.4808C>A	c.(4807-4809)GCA>GAA	p.A1603E		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1603	Cadherin 15.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ATAGTTTCAGCAACAGACCTT	0.453												
TLL1	7092	broad.mit.edu	37	4	166915615	166915615	+	Silent	SNP	C	C	A	rs147468832		TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr4:166915615C>A	uc003irh.1	+	4	1091	c.444C>A	c.(442-444)GCC>GCA	p.A148A	TLL1_uc011cjn.1_Silent_p.A148A|TLL1_uc011cjo.1_5'UTR	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	148	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TTCCCAGAGCCGCTACATCAA	0.418												
SEMA5A	9037	broad.mit.edu	37	5	9227000	9227000	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr5:9227000G>C	uc003jek.2	-	7	1125	c.413C>G	c.(412-414)CCT>CGT	p.P138R		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	138	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GGTGCAGACAGGCGTGAATGC	0.423												
CTNND2	1501	broad.mit.edu	37	5	11384956	11384956	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr5:11384956G>A	uc003jfa.1	-	7	1143	c.998C>T	c.(997-999)TCG>TTG	p.S333L	CTNND2_uc010itt.2_Missense_Mutation_p.S242L|CTNND2_uc011cmy.1_Intron|CTNND2_uc011cmz.1_Intron|CTNND2_uc010itu.1_Intron|CTNND2_uc011cmx.1_5'UTR	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	333					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GGTGGGGGGCGAGGTCACGCG	0.677												
PRDM9	56979	broad.mit.edu	37	5	23526712	23526712	+	Silent	SNP	T	T	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr5:23526712T>C	uc003jgo.2	+	11	1697	c.1515T>C	c.(1513-1515)AAT>AAC	p.N505N		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	505					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGAAAGTGAATCCAGGGAACA	0.438										HNSCC(3;0.000094)		
PRDM9	56979	broad.mit.edu	37	5	23526955	23526955	+	Silent	SNP	G	G	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr5:23526955G>C	uc003jgo.2	+	11	1940	c.1758G>C	c.(1756-1758)GGG>GGC	p.G586G		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	586	C2H2-type 4.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GGGAGTGTGGGCGGGGCTTTA	0.607										HNSCC(3;0.000094)		
SPEF2	79925	broad.mit.edu	37	5	35779396	35779396	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr5:35779396C>T	uc003jjo.2	+	30	4506	c.4395C>T	c.(4393-4395)ACC>ACT	p.T1465T	SPEF2_uc003jjp.1_Silent_p.T951T|SPEF2_uc003jjr.2_5'UTR	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1465					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTACCCTGACCATTGAACAGC	0.383												
NNT	23530	broad.mit.edu	37	5	43609438	43609438	+	Silent	SNP	T	T	C	rs143463864	byFrequency	TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr5:43609438T>C	uc003joe.2	+	2	396	c.141T>C	c.(139-141)CCT>CCC	p.P47P	NNT_uc003jof.2_Silent_p.P47P	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	47	Mitochondrial matrix.				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	GTAAAGCGCCTGTAAAACCAG	0.383												
SRFBP1	153443	broad.mit.edu	37	5	121311043	121311043	+	Silent	SNP	A	A	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr5:121311043A>G	uc003kst.1	+	3	231	c.159A>G	c.(157-159)AGA>AGG	p.R53R		NM_152546	NP_689759	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	53	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm					0		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		AAAACCAAAGACGGGCGCAAA	0.388												
PCDHA9	9752	broad.mit.edu	37	5	140229774	140229774	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr5:140229774T>C	uc003lhu.2	+	1	2418	c.1694T>C	c.(1693-1695)CTG>CCG	p.L565P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.L565P	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	565	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCCGGCGCTGCTGACACCT	0.697												
PCDHB13	56123	broad.mit.edu	37	5	140595824	140595824	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr5:140595824C>A	uc003lja.1	+	1	2316	c.2129C>A	c.(2128-2130)GCG>GAG	p.A710E		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	710	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGTTCGTGGCGGTGCGGCTG	0.677												
IRF4	3662	broad.mit.edu	37	6	394831	394831	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:394831T>C	uc003msz.3	+	3	340	c.227T>C	c.(226-228)CTG>CCG	p.L76P	IRF4_uc010jne.1_Missense_Mutation_p.L76P|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Missense_Mutation_p.L76P|IRF4_uc003mtc.1_5'Flank	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	76	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		GCTTGGGCACTGTTTAAAGGA	0.408			T	IGH@	MM 							
CCDC90A	63933	broad.mit.edu	37	6	13792193	13792193	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:13792193G>T	uc003nbd.2	-	8	1069	c.941C>A	c.(940-942)ACA>AAA	p.T314K	uc003nbc.1_5'Flank|CCDC90A_uc010jpf.2_RNA	NM_001031713	NP_001026883	Q96AQ8	CC90A_HUMAN	coiled-coil domain containing 90A precursor	314						integral to membrane|mitochondrion					0	Breast(50;0.0027)|Ovarian(93;0.0964)	all_hematologic(90;0.117)				CTTCCTGTCTGTCTGGGTAAG	0.458												
ATXN1	6310	broad.mit.edu	37	6	16328351	16328351	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:16328351C>T	uc003nbt.2	-	8	1162	c.191G>A	c.(190-192)GGG>GAG	p.G64E	ATXN1_uc010jpi.2_Missense_Mutation_p.G64E|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	64					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				CACCGAGGTCCCTGCCGGCCC	0.672												
TFEB	7942	broad.mit.edu	37	6	41652678	41652678	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:41652678C>T	uc003oqs.1	-	10	1392	c.1090G>A	c.(1090-1092)GCT>ACT	p.A364T	TFEB_uc003oqt.1_Missense_Mutation_p.A364T|TFEB_uc003oqu.1_Missense_Mutation_p.A378T|TFEB_uc003oqr.1_Missense_Mutation_p.A279T	NM_007162	NP_009093	P19484	TFEB_HUMAN	transcription factor EB	364					embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GGGACCTCAGCCCCCAGCATC	0.682			T	ALPHA	renal (childhood epithelioid)							
FAM83B	222584	broad.mit.edu	37	6	54806546	54806546	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:54806546C>A	uc003pck.2	+	5	2893	c.2777C>A	c.(2776-2778)TCT>TAT	p.S926Y		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	926										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					CTTCTACGATCTCATTCAACT	0.433												
FAM83B	222584	broad.mit.edu	37	6	54806610	54806610	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:54806610T>G	uc003pck.2	+	5	2957	c.2841T>G	c.(2839-2841)ATT>ATG	p.I947M		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	947										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					AGAGCTCTATTCAGCCAACAA	0.438												
DST	667	broad.mit.edu	37	6	56819242	56819242	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:56819242C>T	uc003pdf.2	-	1	172	c.144G>A	c.(142-144)CCG>CCA	p.P48P	BEND6_uc010kab.2_5'Flank|BEND6_uc003pdg.2_5'Flank	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	Error:Variant_position_missing_in_Q03001_after_alignment					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CCGATTTCATCGGATGCCTCC	0.562												
COL9A1	1297	broad.mit.edu	37	6	71004163	71004163	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:71004163C>T	uc003pfg.3	-	5	562	c.403G>A	c.(403-405)GAT>AAT	p.D135N		NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	135	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						CCAGAGGAATCCTGAATCTGC	0.433												
KCNQ5	56479	broad.mit.edu	37	6	73332128	73332128	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:73332128G>A	uc003pgk.2	+	1	558	c.211G>A	c.(211-213)GGC>AGC	p.G71S	KCNQ5_uc003pgj.3_Missense_Mutation_p.G71S|KCNQ5_uc011dyh.1_Missense_Mutation_p.G71S|KCNQ5_uc011dyi.1_Missense_Mutation_p.G71S|KCNQ5_uc010kat.2_Missense_Mutation_p.G71S|KCNQ5_uc011dyj.1_Missense_Mutation_p.G71S|KCNQ5_uc011dyk.1_5'UTR	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	71					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GCTCGGTGGCGGCGGCGGTGG	0.746												
MDN1	23195	broad.mit.edu	37	6	90417179	90417179	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:90417179C>G	uc003pnn.1	-	52	8031	c.7915G>C	c.(7915-7917)GAC>CAC	p.D2639H		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2639					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTTTCCCGGTCAAGATATATG	0.358												
FAM184A	79632	broad.mit.edu	37	6	119338083	119338083	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:119338083C>A	uc003pyj.2	-	5	1707	c.1359G>T	c.(1357-1359)CAG>CAT	p.Q453H	FAM184A_uc003pyk.3_Missense_Mutation_p.Q333H|FAM184A_uc003pyl.3_Missense_Mutation_p.Q333H	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	453	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						AATATTCTTGCTGAGTTCTCT	0.338												
MAN1A1	4121	broad.mit.edu	37	6	119670147	119670147	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:119670147C>T	uc003pym.1	-	2	526	c.84G>A	c.(82-84)AGG>AGA	p.R28R	MAN1A1_uc010kei.1_Silent_p.R28R	NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	28	Cytoplasmic (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		CCGACCCCTTCCTGCCAccgc	0.522												
HEY2	23493	broad.mit.edu	37	6	126080780	126080780	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:126080780C>T	uc003qad.2	+	5	1037	c.846C>T	c.(844-846)TTC>TTT	p.F282F	HEY2_uc011ebr.1_Silent_p.F236F	NM_012259	NP_036391	Q9UBP5	HEY2_HUMAN	hairy/enhancer-of-split related with YRPW motif	282	Ala-rich.				negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		CTCTGTCCTTCGCGGGGGCAT	0.672												
SYNE1	23345	broad.mit.edu	37	6	152718079	152718079	+	Missense_Mutation	SNP	G	G	T	rs144336474		TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:152718079G>T	uc010kiw.2	-	50	7989	c.7387C>A	c.(7387-7389)CTT>ATT	p.L2463I	SYNE1_uc003qot.3_Missense_Mutation_p.L2470I|SYNE1_uc003qou.3_Missense_Mutation_p.L2463I|SYNE1_uc010kjb.1_Missense_Mutation_p.L2446I	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2463	Spectrin 4.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACTGCATCAAGTTTGCTCTGC	0.388										HNSCC(10;0.0054)		
C6orf118	168090	broad.mit.edu	37	6	165715680	165715680	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr6:165715680A>C	uc003qum.3	-	2	167	c.131T>G	c.(130-132)CTT>CGT	p.L44R	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	44											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CCGATTCAGAAGTTTCTTCAG	0.537												
TMEM195	392636	broad.mit.edu	37	7	15405215	15405215	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr7:15405215C>T	uc003stb.1	-	12	1357	c.1187G>A	c.(1186-1188)CGT>CAT	p.R396H		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	396					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						CATCAAGCAACGGAGAGTTTC	0.363												
NFE2L3	9603	broad.mit.edu	37	7	26224557	26224557	+	Silent	SNP	T	T	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr7:26224557T>C	uc003sxq.2	+	4	1511	c.1239T>C	c.(1237-1239)GAT>GAC	p.D413D		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	413					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						AGCTTTTTGATGAACCAGATT	0.363												
ZNF479	90827	broad.mit.edu	37	7	57188696	57188696	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr7:57188696A>T	uc010kzo.2	-	5	697	c.426T>A	c.(424-426)TAT>TAA	p.Y142*		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TAACTTCACTATAACCTCCCT	0.308												
DNAJC30	84277	broad.mit.edu	37	7	73097334	73097334	+	Silent	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr7:73097334G>A	uc003tys.1	-	1	448	c.420C>T	c.(418-420)ACC>ACT	p.T140T	WBSCR22_uc010lbi.1_5'Flank|WBSCR22_uc003tyt.2_5'Flank|WBSCR22_uc003tyu.2_5'Flank|WBSCR22_uc003tyv.2_5'Flank|WBSCR22_uc003tyw.1_5'Flank	NM_032317	NP_115693	Q96LL9	DJC30_HUMAN	DnaJ (Hsp40) homolog subfamily C member 30	140					protein folding		heat shock protein binding|unfolded protein binding				0						TGGGCGGCGGGGTACGCGGCG	0.711												
LMOD2	442721	broad.mit.edu	37	7	123302309	123302309	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr7:123302309C>T	uc003vky.2	+	2	826	c.669C>T	c.(667-669)AAC>AAT	p.N223N		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	223						cytoskeleton	actin binding|tropomyosin binding				0						ACATTGAGAACATCACAACAC	0.483												
ADCK2	90956	broad.mit.edu	37	7	140373462	140373462	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr7:140373462T>C	uc003vvy.1	+	1	510	c.332T>C	c.(331-333)TTC>TCC	p.F111S	ADCK2_uc003vvz.2_Missense_Mutation_p.F111S	NM_052853	NP_443085	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	111	Helical; (Potential).					integral to membrane	ATP binding|protein serine/threonine kinase activity				0	Melanoma(164;0.00956)					GTGAAATTCTTCCCCCTCCTA	0.677												
CASP2	835	broad.mit.edu	37	7	142989724	142989724	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr7:142989724C>T	uc003wco.2	+	4	555	c.408C>T	c.(406-408)TAC>TAT	p.Y136Y	CASP2_uc003wcp.2_Intron|CASP2_uc011kta.1_Silent_p.Y20Y|CASP2_uc003wcq.2_RNA	NM_032982	NP_116764	P42575	CASP2_HUMAN	caspase 2 isoform 1 preproprotein	136					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			lung(2)|ovary(1)	3	Melanoma(164;0.059)					GCTGTGACTACGACTTGAGTC	0.473												
OR2A2	442361	broad.mit.edu	37	7	143807364	143807364	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr7:143807364A>C	uc011ktz.1	+	1	689	c.689A>C	c.(688-690)AAG>ACG	p.K230T		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					ATCCAGACAAAGGAGGGCCGC	0.517												
PTPRN2	5799	broad.mit.edu	37	7	157931128	157931128	+	Silent	SNP	G	G	A	rs140368368		TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr7:157931128G>A	uc003wno.2	-	7	1111	c.990C>T	c.(988-990)GAC>GAT	p.D330D	PTPRN2_uc003wnp.2_Silent_p.D313D|PTPRN2_uc003wnq.2_Silent_p.D330D|PTPRN2_uc003wnr.2_Silent_p.D292D|PTPRN2_uc011kwa.1_Silent_p.D353D	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	330	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CAGCCATGCCGTCCAGCTCCA	0.637												
DLGAP2	9228	broad.mit.edu	37	8	1497185	1497185	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr8:1497185C>T	uc003wpl.2	+	2	423	c.326C>T	c.(325-327)CCG>CTG	p.P109L	DLGAP2_uc003wpm.2_Missense_Mutation_p.P109L	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	188					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		AACCGCATCCCGGCCAACCTG	0.687												
TEX15	56154	broad.mit.edu	37	8	30701748	30701748	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr8:30701748A>G	uc003xil.2	-	1	4786	c.4786T>C	c.(4786-4788)TCA>CCA	p.S1596P		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1596										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CTCACGTATGACGCAGGTTTC	0.398												
TEX15	56154	broad.mit.edu	37	8	30701929	30701929	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr8:30701929C>T	uc003xil.2	-	1	4605	c.4605G>A	c.(4603-4605)CCG>CCA	p.P1535P		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1535										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTTTGTTAAGCGGATTAGAAA	0.353												
TEX15	56154	broad.mit.edu	37	8	30704291	30704291	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr8:30704291T>G	uc003xil.2	-	1	2243	c.2243A>C	c.(2242-2244)AAG>ACG	p.K748T		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	748										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GTTACTTTCCTTAGAATAATG	0.353												
PGCP	10404	broad.mit.edu	37	8	98078419	98078419	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr8:98078419G>A	uc003yhw.2	+	7	1402	c.1236G>A	c.(1234-1236)TGG>TGA	p.W412*		NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	412					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					TCAACTTTTGGATCCAAGCTG	0.433												
EIF2C2	27161	broad.mit.edu	37	8	141545600	141545600	+	Silent	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr8:141545600G>A	uc003yvn.2	-	17	2278	c.2238C>T	c.(2236-2238)TTC>TTT	p.F746F	EIF2C2_uc010men.2_Silent_p.F669F|EIF2C2_uc010meo.2_Intron	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	746	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			GGTAGAAGTCGAACTCGGTGG	0.562												
PTCH1	5727	broad.mit.edu	37	9	98241322	98241322	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr9:98241322G>A	uc004avk.3	-	8	1363	c.1175C>T	c.(1174-1176)GCG>GTG	p.A392V	PTCH1_uc010mro.2_Missense_Mutation_p.A241V|PTCH1_uc010mrp.2_Missense_Mutation_p.A241V|PTCH1_uc010mrq.2_Missense_Mutation_p.A241V|PTCH1_uc004avl.3_Missense_Mutation_p.A241V|PTCH1_uc010mrr.2_Missense_Mutation_p.A326V|PTCH1_uc004avm.3_Missense_Mutation_p.A391V|PTCH1_uc010mrs.1_Missense_Mutation_p.A112V	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	392	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				GATGGCTGCCGCTTTGTCCTC	0.517									Basal_Cell_Nevus_syndrome			
FAM78A	286336	broad.mit.edu	37	9	134136311	134136311	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr9:134136311C>T	uc004cak.2	-	2	1090	c.750G>A	c.(748-750)CCG>CCA	p.P250P	FAM78A_uc004caj.2_Silent_p.P247P	NM_033387	NP_203745	Q5JUQ0	FA78A_HUMAN	hypothetical protein LOC286336	250										ovary(1)	1	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)		GGGCGCTGGGCGGGATGGGCT	0.687												
KDM5C	8242	broad.mit.edu	37	X	53243871	53243871	+	Silent	SNP	C	C	T			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chrX:53243871C>T	uc004drz.2	-	8	1655	c.1122G>A	c.(1120-1122)GCG>GCA	p.A374A	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Silent_p.A307A|KDM5C_uc004dsa.2_Silent_p.A373A	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	374					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						GAGGCCTTACCGCCATGACAC	0.557			N|F|S		clear cell renal carcinoma							
LPCAT1	79888	broad.mit.edu	37	5	1471036	1471052	+	Splice_Site	DEL	CGCTCTGTGGGGAGAGA	CGCTCTGTGGGGAGAGA	-			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr5:1471035_1471051CCGCTCTGTGGGGAGAGA>C	uc003jcm.3	-	12	1297	c.1180_splice	c.e12-1	p.S394_splice		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	Homo sapiens lysophosphatidylcholine acyltransferase 1 (LPCAT1), mRNA.	394	EF-hand 1.				phospholipid biosynthetic process	Golgi membrane|endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		CTCGCCGCTGCCGCTCTGTGGGGAGAGACGCTCTCAG	0.636												
COPB1	1315	broad.mit.edu	37	11	14520475	14520476	+	Translation_Start_Site	INS	-	-	GGTTTCTG			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr11:14520474_14520475T>TGGTTTCTG	uc001mlh.2	-	1					COPB1_uc001mli.2_Start_Codon_Ins|COPB1_uc001mlg.2_Start_Codon_Ins|PSMA1_uc010rcp.1_Non-coding_Transcript	NM_001144061	NP_057535	P53618	COPB_HUMAN	Homo sapiens coatomer protein complex, subunit beta 1 (COPB1), transcript variant 2, mRNA.						COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|ER-Golgi intermediate compartment|cytosol|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						GCCGCCGTCATGGTTTCTGGTT	0.337												
GAS6	2621	broad.mit.edu	37	13	114542799	114542799	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr13:114542799delT	uc001vud.2	-	5	521	c.368delA	c.(367-369)AACfs	p.N123fs	uc010tki.1_5'Flank	NM_000820	NP_000811	Q14393	GAS6_HUMAN	growth arrest-specific 6 isoform 1 precursor	123	EGF-like 1; calcium-binding (Potential).				cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)	4	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				ATCGCAGGGGTTGGGCGTGCA	0.622												
RPS6KC1	26750	broad.mit.edu	37	1	213415473	213415475	+	In_Frame_Del	DEL	TTT	TTT	-			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr1:213415472_213415474ATTT>A	uc010ptr.2	+	10	2812_2814	c.2653_2655ATTT>A	c.(2653-2655)att>A	p.I885del	RPS6KC1_uc001hkd.3_In_Frame_Del_p.I873del|RPS6KC1_uc010pts.2_In_Frame_Del_p.I673del|RPS6KC1_uc010ptt.2_In_Frame_Del_p.I673del|RPS6KC1_uc010ptu.2_In_Frame_Del_p.I704del|RPS6KC1_uc010ptv.2_In_Frame_Del_p.I420del|RPS6KC1_uc001hke.3_In_Frame_Del_p.I704del	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	Homo sapiens ribosomal protein S6 kinase, 52kDa, polypeptide 1 (RPS6KC1), transcript variant 1, mRNA.	885	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		AATACATCAGATTTTTGAGGACC	0.429												
METTL14	57721	broad.mit.edu	37	4	119631250	119631261	+	In_Frame_Del	DEL	TACAGAAGAAAT	TACAGAAGAAAT	-			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr4:119631249_119631260GTACAGAAGAAAT>G	uc003icf.3	+	10	1279_1290	c.1163_1174GTACAGAAGAAAT>G	c.(1162-1176)tgtacagaagaaatt>tGtt	p.TEEI389del		NM_020961	NP_066012	Q9HCE5	MTL14_HUMAN	Homo sapiens methyltransferase like 14 (METTL14), mRNA.	389						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|stomach(1)	16						TTGACTGGTTGTACAGAAGAAATTGAGAGACT	0.481												
LPCAT1	79888	broad.mit.edu	37	5	1471036	1471052	+	Splice_Site	DEL	CGCTCTGTGGGGAGAGA	CGCTCTGTGGGGAGAGA	-			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr5:1471035_1471051CCGCTCTGTGGGGAGAGA>C	uc003jcm.3	-	12	1297	c.1180_splice	c.e12-1	p.S394_splice		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	Homo sapiens lysophosphatidylcholine acyltransferase 1 (LPCAT1), mRNA.	394	EF-hand 1.				phospholipid biosynthetic process	Golgi membrane|endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		CTCGCCGCTGCCGCTCTGTGGGGAGAGACGCTCTCAG	0.636												
COPB1	1315	broad.mit.edu	37	11	14520475	14520476	+	Translation_Start_Site	INS	-	-	GGTTTCTG			TCGA-BR-A4CQ-01A-12D-A25D-08	TCGA-BR-A4CQ-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890f6174-6b66-43a0-a669-1e45b3b86963	51dbd017-e043-4ae0-86d5-a4a2dd76bf2c	g.chr11:14520474_14520475T>TGGTTTCTG	uc001mlh.2	-	1					COPB1_uc001mli.2_Start_Codon_Ins|COPB1_uc001mlg.2_Start_Codon_Ins|PSMA1_uc010rcp.1_Non-coding_Transcript	NM_001144061	NP_057535	P53618	COPB_HUMAN	Homo sapiens coatomer protein complex, subunit beta 1 (COPB1), transcript variant 2, mRNA.						COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|ER-Golgi intermediate compartment|cytosol|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						GCCGCCGTCATGGTTTCTGGTT	0.337