Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
S100PBP	64766	broad.mit.edu	37	1	33291908	33291908	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:33291908G>A	uc001bvz.2	+	3	485	c.208G>A	c.(208-210)GAG>AAG	p.E70K	S100PBP_uc001bwa.1_Missense_Mutation_p.E70K|S100PBP_uc001bwb.1_Missense_Mutation_p.E70K|S100PBP_uc001bwc.2_Missense_Mutation_p.E70K|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	70						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CCCATCATATGAGCAGTCTTC	0.453000												
MAP7D1	55700	broad.mit.edu	37	1	36645160	36645160	+	Splice_Site	SNP	T	T	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:36645160T>C	uc001bzz.2	+	14	2446	c.2230_splice	c.e14+2	p.E744_splice	MAP7D1_uc001caa.2_Splice_Site_p.E711_splice|MAP7D1_uc001cab.2_Splice_Site_p.E706_splice|MAP7D1_uc001cac.2_Splice_Site_p.E443_splice|MAP7D1_uc001cad.2_Splice_Site_p.E280_splice	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1							cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				CCAGCCCAGGTAAAGccccca	0.388000												
STK40	83931	broad.mit.edu	37	1	36807526	36807526	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:36807526G>A	uc001cak.1	-	12	1545	c.1138C>T	c.(1138-1140)CGT>TGT	p.R380C	STK40_uc001cal.1_Missense_Mutation_p.R385C|STK40_uc001cam.1_Missense_Mutation_p.R380C|STK40_uc009vva.1_3'UTR|STK40_uc001can.1_3'UTR	NM_032017	NP_114406	Q8N2I9	STK40_HUMAN	serine/threonine kinase 40	380						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)				AGCTGCTGACGCATGTAGTTC	0.612000												
GLIS1	148979	broad.mit.edu	37	1	54059815	54059815	+	Missense_Mutation	SNP	C	C	T	rs145199173		TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:54059815C>T	uc001cvr.1	-	3	1328	c.761G>A	c.(760-762)CGA>CAA	p.R254Q		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	254	C2H2-type 2; atypical.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						CGAGTGCACTCGCATGTGGAT	0.652000												
DIRAS3	9077	broad.mit.edu	37	1	68512693	68512693	+	Silent	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:68512693G>A	uc001ded.2	-	2	583	c.288C>T	c.(286-288)GAC>GAT	p.D96D	uc001deb.1_Intron|uc001dec.1_Intron	NM_004675	NP_004666	O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	96					regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			skin(1)	1						CGCGGTTGCCGTCGCCACTCT	0.592000												
ELTD1	64123	broad.mit.edu	37	1	79386012	79386012	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:79386012C>T	uc001diq.3	-	10	1473	c.1317G>A	c.(1315-1317)CTG>CTA	p.L439L		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	439	Helical; Name=1; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		CAAGACAAATCAGTGAAATAA	0.308000												
VAV3	10451	broad.mit.edu	37	1	108152584	108152584	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:108152584G>A	uc001dvk.1	-	22	2038	c.1984C>T	c.(1984-1986)CCC>TCC	p.P662S	VAV3_uc010ouu.1_Missense_Mutation_p.P66S|VAV3_uc001dvj.1_Missense_Mutation_p.P102S|VAV3_uc010ouv.1_Missense_Mutation_p.P66S|VAV3_uc010ouw.1_Missense_Mutation_p.P662S	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	662					angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		ACTGGTTTGGGCACCTAGGAT	0.348000												
TTF2	8458	broad.mit.edu	37	1	117618400	117618400	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:117618400C>T	uc001egy.2	+	5	1214	c.1194C>T	c.(1192-1194)GCC>GCT	p.A398A	TTF2_uc001egx.1_Silent_p.A398A	NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	398					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		TGTCTCCTGCCTCAGGTGTTT	0.493000												
DENND4B	9909	broad.mit.edu	37	1	153914789	153914789	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:153914789C>T	uc001fdd.1	-	5	1085	c.684G>A	c.(682-684)CCG>CCA	p.P228P		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	228	UDENN.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			ACTCGGGCAGCGGGAACGCCT	0.637000												
TIPRL	261726	broad.mit.edu	37	1	168169139	168169139	+	Splice_Site	SNP	A	A	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:168169139A>G	uc001gfg.2	+	7	821	c.676_splice	c.e7-2	p.H226_splice	TIPRL_uc001gfh.2_Splice_Site_p.T227_splice	NM_152902	NP_690866	O75663	TIPRL_HUMAN	TIP41, TOR signalling pathway regulator-like						DNA damage checkpoint|negative regulation of protein phosphatase type 2A activity	cytoplasm	protein binding			ovary(1)	1	all_hematologic(923;0.215)					TGTATTTCCTAGCATGTTCCA	0.313000												
RABGAP1L	9910	broad.mit.edu	37	1	174606593	174606593	+	Silent	SNP	A	A	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:174606593A>T	uc001gjx.2	+	14	1986	c.1791A>T	c.(1789-1791)GGA>GGT	p.G597G		NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	597	Rab-GAP TBC.				regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						ATACTGGAGGAGATGGTCAAG	0.363000												
CEP350	9857	broad.mit.edu	37	1	179989418	179989418	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:179989418A>C	uc001gnt.2	+	12	2892	c.2509A>C	c.(2509-2511)AGC>CGC	p.S837R	CEP350_uc009wxl.2_Missense_Mutation_p.S836R|CEP350_uc001gnu.2_Missense_Mutation_p.S671R	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	837						centrosome|nucleus|spindle				ovary(4)	4						TTCTTTGTCCAGCAGAATTGA	0.443000												
ASPM	259266	broad.mit.edu	37	1	197112225	197112225	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:197112225G>A	uc001gtu.2	-	3	1414	c.1157C>T	c.(1156-1158)TCA>TTA	p.S386L	ASPM_uc001gtv.2_Missense_Mutation_p.S386L|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	386					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						AGGATTAACTGACTCTGATTC	0.279000												
WDR64	128025	broad.mit.edu	37	1	241959588	241959588	+	Silent	SNP	T	T	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:241959588T>A	uc001hzf.1	+	16	1890	c.1737T>A	c.(1735-1737)CTT>CTA	p.L579L	WDR64_uc001hzg.1_Silent_p.L492L	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	1026										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			TAAGATTTCTTCCACTGATTG	0.398000												
ITIH2	3698	broad.mit.edu	37	10	7759715	7759715	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr10:7759715C>T	uc001ijs.2	+	6	756	c.594C>T	c.(592-594)ATC>ATT	p.I198I		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	198					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						AGCACAGGATCTATCTGCAAC	0.507000												
PGBD3	267004	broad.mit.edu	37	10	50732318	50732318	+	Translation_Start_Site	SNP	G	G	A	rs141391984	byFrequency	TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr10:50732318G>A	uc001jht.2	-	1	9	c.-246C>T	c.(-248--244)GACGA>GATGA		ERCC6_uc001jhs.3_Silent_p.D386D|PGBD3_uc009xoe.2_Silent_p.D386D|PGBD3_uc001jhu.2_Silent_p.D386D	NM_170753	NP_736609	Q8N328	PGBD3_HUMAN	hypothetical protein LOC267004											pancreas(1)|breast(1)|skin(1)	3						cctccacctcgtcatcttcct	0.423000												
A1CF	29974	broad.mit.edu	37	10	52603780	52603780	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr10:52603780A>C	uc001jjj.2	-	4	390	c.202T>G	c.(202-204)TTT>GTT	p.F68V	A1CF_uc010qhn.1_Missense_Mutation_p.F76V|A1CF_uc001jji.2_Missense_Mutation_p.F68V|A1CF_uc001jjh.2_Missense_Mutation_p.F76V|A1CF_uc010qho.1_Missense_Mutation_p.F76V|A1CF_uc009xov.2_Missense_Mutation_p.F68V|A1CF_uc001jjk.1_Missense_Mutation_p.F68V	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	68	RRM 1.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						TCATCCTCAAAAAGGTCTCGG	0.393000												
RUFY2	55680	broad.mit.edu	37	10	70143864	70143864	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr10:70143864G>A	uc001job.2	-	9	1198	c.871C>T	c.(871-873)CAT>TAT	p.H291Y	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joc.2_Missense_Mutation_p.H222Y|RUFY2_uc010qiw.1_Missense_Mutation_p.H198Y|RUFY2_uc001jod.1_Missense_Mutation_p.H256Y|RUFY2_uc009xpv.1_Missense_Mutation_p.H139Y	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	305	Potential.					nucleus	metal ion binding			ovary(1)	1						CGTAATTGATGATTTTCTTCC	0.318000												
BLNK	29760	broad.mit.edu	37	10	97983645	97983645	+	Silent	SNP	C	C	T	rs149698554		TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr10:97983645C>T	uc001kls.3	-	6	640	c.462G>A	c.(460-462)CCG>CCA	p.P154P	BLNK_uc001kme.3_Silent_p.P72P|BLNK_uc001klt.3_Silent_p.P68P|BLNK_uc009xvc.2_Intron|BLNK_uc001klu.3_Silent_p.P72P|BLNK_uc001klv.3_Intron|BLNK_uc001klw.3_RNA|BLNK_uc001klx.3_Silent_p.P154P|BLNK_uc001kly.3_Silent_p.P154P|BLNK_uc001klz.3_Intron|BLNK_uc001kma.3_Silent_p.P154P|BLNK_uc001kmb.3_Intron|BLNK_uc001kmc.3_RNA|BLNK_uc001kmd.3_Silent_p.P72P|BLNK_uc009xvd.2_Intron	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	154	Pro-rich.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		CAGTCAGGGCCGGCAGGGTGG	0.547000												
HPS1	3257	broad.mit.edu	37	10	100183378	100183378	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr10:100183378C>T	uc010qpf.1	-	16	1826	c.1580G>A	c.(1579-1581)AGG>AAG	p.R527K	HPS1_uc001kpi.1_Missense_Mutation_p.R527K|HPS1_uc001kpj.1_Missense_Mutation_p.R434K|HPS1_uc001kpk.1_Missense_Mutation_p.R351K|HPS1_uc010qpg.1_Missense_Mutation_p.R147K|HPS1_uc009xwb.2_RNA	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1 protein isoform a	527					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		GGTGATGTTCCTCCTGCTCTT	0.617000									Hermansky-Pudlak_syndrome			
ABLIM1	3983	broad.mit.edu	37	10	116361626	116361626	+	Silent	SNP	G	G	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr10:116361626G>C	uc010qsg.1	-	2	438	c.339C>G	c.(337-339)GTC>GTG	p.V113V	ABLIM1_uc010qsh.1_Silent_p.V53V|ABLIM1_uc010qsi.1_Silent_p.V53V|ABLIM1_uc010qsk.1_Silent_p.V37V|ABLIM1_uc009xyp.2_Silent_p.V47V|ABLIM1_uc001lbz.1_Silent_p.V36V	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	113	LIM zinc-binding 1.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		GTTTGGTCTGGACCCGAAGCA	0.557000												
KNDC1	85442	broad.mit.edu	37	10	135015105	135015105	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr10:135015105C>T	uc001llz.1	+	17	3091	c.3090C>T	c.(3088-3090)TTC>TTT	p.F1030F	KNDC1_uc001lma.1_Silent_p.F965F|KNDC1_uc001lmb.1_Silent_p.F442F	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1030					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GGGGAAACTTCGAGGTGGGGT	0.657000												
ART1	417	broad.mit.edu	37	11	3681342	3681342	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr11:3681342G>A	uc001lye.1	+	3	694	c.593G>A	c.(592-594)GGG>GAG	p.G198E	ART1_uc009yeb.1_Missense_Mutation_p.G198E	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	198					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	GTGAGGCTGGGGGGCTTTGCT	0.682000												
OR51M1	390059	broad.mit.edu	37	11	5410661	5410661	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr11:5410661C>T	uc010qzc.1	+	1	33	c.33C>T	c.(31-33)TTC>TTT	p.F11F	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	11						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTCCTCAATTCATGCTGCTAT	0.398000												
MICAL2	9645	broad.mit.edu	37	11	12241844	12241844	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr11:12241844T>A	uc001mjz.2	+	9	1333	c.1045T>A	c.(1045-1047)TAC>AAC	p.Y349N	MICAL2_uc010rch.1_Missense_Mutation_p.Y349N|MICAL2_uc001mka.2_Missense_Mutation_p.Y349N|MICAL2_uc010rci.1_Missense_Mutation_p.Y349N|MICAL2_uc001mkb.2_Missense_Mutation_p.Y349N|MICAL2_uc001mkc.2_Missense_Mutation_p.Y349N|MICAL2_uc001mkd.2_Missense_Mutation_p.Y178N|MICAL2_uc010rcj.1_5'Flank	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	349						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		TGCCACCAACTACCAGCTGCC	0.537000												
SPTY2D1	144108	broad.mit.edu	37	11	18636652	18636652	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr11:18636652G>T	uc001moy.2	-	3	1385	c.1169C>A	c.(1168-1170)ACA>AAA	p.T390K	SPTY2D1_uc010rdi.1_Missense_Mutation_p.T390K	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	390	Ser-rich.									breast(1)	1						AGAACTAACTGTGGGTCGAGC	0.587000												
LIN7C	55327	broad.mit.edu	37	11	27520261	27520261	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr11:27520261C>T	uc001mrl.2	-	5	556	c.529G>A	c.(529-531)GTC>ATC	p.V177I	LIN7C_uc009yii.2_Missense_Mutation_p.V153I	NM_018362	NP_060832	Q9NUP9	LIN7C_HUMAN	lin-7 homolog C	177					exocytosis|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction					0						TCTTCTAAGACTTTGGGTGTG	0.388000												
KIF18A	81930	broad.mit.edu	37	11	28090850	28090850	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr11:28090850C>T	uc001msc.2	-	11	1728	c.1546G>A	c.(1546-1548)GAA>AAA	p.E516K		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	516					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						ATTTCTTTTTCGACACGATGG	0.388000												
DDB1	1642	broad.mit.edu	37	11	61071504	61071504	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr11:61071504G>A	uc001nrc.3	-	22	2891	c.2665C>T	c.(2665-2667)CGG>TGG	p.R889W	DDB1_uc010rle.1_Missense_Mutation_p.R200W|DDB1_uc010rlf.1_Missense_Mutation_p.R889W	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	889	Interaction with CDT1 and CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						TCATAGAGCCGCACCTGGGAA	0.547000								NER				
CST6	1474	broad.mit.edu	37	11	65780867	65780867	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr11:65780867T>A	uc001ogr.2	+	3	500	c.446T>A	c.(445-447)ATG>AAG	p.M149K	CST6_uc001ogs.1_3'UTR	NM_001323	NP_001314	Q15828	CYTM_HUMAN	cystatin M precursor	149					anatomical structure morphogenesis	extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1						TGTGTGCAGATGTGATAAGTC	0.562000												
CPT1A	1374	broad.mit.edu	37	11	68566686	68566686	+	Silent	SNP	G	G	A	rs146551320		TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr11:68566686G>A	uc001oog.3	-	6	863	c.693C>T	c.(691-693)TAC>TAT	p.Y231Y	CPT1A_uc001oof.3_Silent_p.Y231Y|CPT1A_uc009ysj.2_Silent_p.Y231Y	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	231	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	ACAGACTTACGTAATTTGTAG	0.398000												
INTS4	92105	broad.mit.edu	37	11	77635908	77635908	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr11:77635908G>A	uc001oys.2	-	12	1430	c.1402C>T	c.(1402-1404)CAT>TAT	p.H468Y	INTS4_uc001oyt.2_RNA|INTS4_uc001oyu.1_Missense_Mutation_p.H468Y	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	468	HEAT 8.				snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			AAGAGTTCATGAAGAGCCTCT	0.383000												
DDI1	414301	broad.mit.edu	37	11	103907617	103907617	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr11:103907617C>A	uc001phr.2	+	1	310	c.67C>A	c.(67-69)CCC>ACC	p.P23T	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	23	Ubiquitin-like.				proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		CCAGGTCAGCCCCGACTTTGA	0.512000												
LAYN	143903	broad.mit.edu	37	11	111414845	111414845	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr11:111414845G>T	uc001plr.1	+	3	643	c.307G>T	c.(307-309)GAC>TAC	p.D103Y	LAYN_uc001plp.1_Missense_Mutation_p.D95Y|LAYN_uc001plq.1_Missense_Mutation_p.D103Y|LAYN_uc001pls.1_Missense_Mutation_p.D95Y|LAYN_uc010rwg.1_Silent_p.V2V|LAYN_uc010rwh.1_5'UTR	NM_178834	NP_849156	Q6UX15	LAYN_HUMAN	layilin	103	C-type lectin.|Extracellular (Potential).					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding				0		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		ATCTGATGGTGACTTCTGGAT	0.483000												
SLCO1C1	53919	broad.mit.edu	37	12	20903643	20903643	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr12:20903643G>C	uc001rej.3	+	15	2188	c.1833G>C	c.(1831-1833)TTG>TTC	p.L611F	SLCO1C1_uc010sii.1_Missense_Mutation_p.L611F|SLCO1C1_uc010sij.1_Missense_Mutation_p.L562F|SLCO1C1_uc009zip.2_Missense_Mutation_p.L445F|SLCO1C1_uc001rei.2_Missense_Mutation_p.L611F|SLCO1C1_uc010sik.1_Missense_Mutation_p.L493F	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	611	Helical; Name=11; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TTGGAGTTTTGATTGATACTT	0.343000												
ALG10B	144245	broad.mit.edu	37	12	38714150	38714150	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr12:38714150G>A	uc001rln.3	+	3	696	c.557G>A	c.(556-558)CGG>CAG	p.R186Q	ALG10B_uc001rlo.3_Missense_Mutation_p.R156Q|ALG10B_uc010skk.1_Missense_Mutation_p.R126Q	NM_001013620	NP_001013642	Q5I7T1	AG10B_HUMAN	asparagine-linked glycosylation 10 homolog B	186	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			ovary(2)|skin(1)	3	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				TTCATGTTTCGGCAAACAAAT	0.383000												
DNAJC22	79962	broad.mit.edu	37	12	49743129	49743129	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr12:49743129C>T	uc001rua.2	+	2	875	c.474C>T	c.(472-474)GCC>GCT	p.A158A	DNAJC22_uc001rub.2_Silent_p.A158A	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	158	Helical; (Potential).				protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						TTAGCGTGGCCGCCAGCATTA	0.547000												
B4GALNT1	2583	broad.mit.edu	37	12	58024855	58024855	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr12:58024855G>A	uc001spg.1	-	4	830	c.398C>T	c.(397-399)GCT>GTT	p.A133V	B4GALNT1_uc010sru.1_Missense_Mutation_p.A78V|B4GALNT1_uc010srv.1_Missense_Mutation_p.A133V|B4GALNT1_uc001sph.2_Missense_Mutation_p.A133V|B4GALNT1_uc001spi.2_Missense_Mutation_p.A133V	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	133	Lumenal (Potential).				lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity				0	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			CAGCTGGTCAGCTGGGGACTG	0.642000												
TRHDE	29953	broad.mit.edu	37	12	73056851	73056851	+	Missense_Mutation	SNP	A	A	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr12:73056851A>T	uc001sxa.2	+	19	2981	c.2951A>T	c.(2950-2952)AAC>ATC	p.N984I		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	984	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TTCATGAAAAACTATGATGGG	0.398000												
SELPLG	6404	broad.mit.edu	37	12	109017971	109017971	+	Missense_Mutation	SNP	C	C	T	rs149021318	byFrequency	TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr12:109017971C>T	uc001tni.2	-	2	273	c.113G>A	c.(112-114)CGG>CAG	p.R38Q	SELPLG_uc001tnh.2_Missense_Mutation_p.R38Q|SELPLG_uc010sxe.1_Missense_Mutation_p.R54Q	NM_003006	NP_002997	Q14242	SELPL_HUMAN	selectin P ligand	38	Extracellular (Potential).			Missing (in Ref. 3; BAC05283).	blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding				0						TCTCCGGTCCCGGGCAAGCAG	0.572000												
WDR66	144406	broad.mit.edu	37	12	122398586	122398586	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr12:122398586C>G	uc009zxk.2	+	14	2371	c.2229C>G	c.(2227-2229)AGC>AGG	p.S743R		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	743							calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		ATCGCAAAAGCATTCGAAGTC	0.483000												
CLIP1	6249	broad.mit.edu	37	12	122845543	122845543	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr12:122845543G>A	uc001ucg.1	-	4	1074	c.968C>T	c.(967-969)GCC>GTC	p.A323V	CLIP1_uc001uch.1_Missense_Mutation_p.A323V|CLIP1_uc001uci.1_Missense_Mutation_p.A323V|CLIP1_uc001ucj.1_Missense_Mutation_p.A24V|CLIP1_uc010tae.1_Missense_Mutation_p.A323V	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	323	Ser-rich.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CACAGAGGAGGCCACTGAGCT	0.617000												
EP400	57634	broad.mit.edu	37	12	132514347	132514347	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr12:132514347G>A	uc001ujn.2	+	27	5518	c.5483G>A	c.(5482-5484)GGC>GAC	p.G1828D	EP400_uc001ujl.2_Missense_Mutation_p.G1827D|EP400_uc001ujm.2_Missense_Mutation_p.G1747D|SNORA49_uc001ujo.2_5'Flank	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1864					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TTGAGGCAGGGCCTGAGAGAG	0.657000												
FREM2	341640	broad.mit.edu	37	13	39266549	39266549	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr13:39266549G>A	uc001uwv.2	+	1	5377	c.5068G>A	c.(5068-5070)GAC>AAC	p.D1690N		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1690	Extracellular (Potential).|CSPG 12.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGAGGACAGAGACAGCTTACA	0.473000												
THSD1	55901	broad.mit.edu	37	13	52952350	52952350	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr13:52952350G>C	uc001vgo.2	-	5	2300	c.1755C>G	c.(1753-1755)TTC>TTG	p.F585L	THSD1_uc001vgp.2_Missense_Mutation_p.F532L|THSD1_uc010tgz.1_Missense_Mutation_p.F206L|THSD1_uc010aea.2_Missense_Mutation_p.F46L	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	585	Cytoplasmic (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		ATTTGATCCGGAACTTGTTTG	0.572000												
DIAPH3	81624	broad.mit.edu	37	13	60240797	60240797	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr13:60240797G>A	uc001vht.2	-	28	3722	c.3503C>T	c.(3502-3504)ACG>ATG	p.T1168M	DIAPH3_uc001vhs.2_RNA	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	1168					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AAGAAGTTCCGTTTCCTTTTT	0.383000												
EDNRB	1910	broad.mit.edu	37	13	78492651	78492651	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr13:78492651C>T	uc001vko.2	-	1	316	c.58G>A	c.(58-60)GGC>AGC	p.G20S	uc001vks.2_5'Flank|EDNRB_uc001vkq.1_Missense_Mutation_p.G20S|EDNRB_uc010aez.1_Missense_Mutation_p.G20S|EDNRB_uc001vkp.1_Missense_Mutation_p.G103S|EDNRB_uc010afa.1_Missense_Mutation_p.G20S	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	20					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	CGCGACAGGCCGCAGGCAAGA	0.642000											OREG0022452	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
OR4N2	390429	broad.mit.edu	37	14	20295827	20295827	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr14:20295827T>G	uc010tkv.1	+	1	220	c.220T>G	c.(220-222)TCC>GCC	p.S74A		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGCATCCTACTCCTTCATTGT	0.483000												
LRFN5	145581	broad.mit.edu	37	14	42356201	42356201	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr14:42356201C>T	uc001wvm.2	+	3	1571	c.373C>T	c.(373-375)CTT>TTT	p.L125F	LRFN5_uc010ana.2_Missense_Mutation_p.L125F	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	125	Extracellular (Potential).|LRR 4.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TCTTTCCAATCTTCATCATTT	0.383000										HNSCC(30;0.082)		
COQ6	51004	broad.mit.edu	37	14	74428508	74428508	+	Missense_Mutation	SNP	A	A	G	rs150656371		TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr14:74428508A>G	uc001xph.2	+	11	1359	c.1279A>G	c.(1279-1281)ACA>GCA	p.T427A	ENTPD5_uc001xpi.2_Intron|COQ6_uc001xpe.2_Missense_Mutation_p.T352A|COQ6_uc001xpf.2_Missense_Mutation_p.T352A|COQ6_uc010tuk.1_Missense_Mutation_p.T402A|COQ6_uc001xpg.2_Intron	NM_182476	NP_872282	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 homolog isoform a	427					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.00337)		TCTGGCTGCTACAGACTTACT	0.498000												
TRIP11	9321	broad.mit.edu	37	14	92469890	92469890	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr14:92469890G>C	uc001xzy.2	-	11	5218	c.4430C>G	c.(4429-4431)ACA>AGA	p.T1477R	TRIP11_uc010auf.1_Missense_Mutation_p.T1213R	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1477	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TTGATATTCTGTTTCCTTTCC	0.368000			T	PDGFRB	AML							
SERPINA1	5265	broad.mit.edu	37	14	94847294	94847294	+	Silent	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr14:94847294G>A	uc001ycx.3	-	3	1092	c.831C>T	c.(829-831)TTC>TTT	p.F277F	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Silent_p.F277F|SERPINA1_uc010aux.2_Silent_p.F277F|SERPINA1_uc001ycy.3_Silent_p.F277F|SERPINA1_uc010auy.2_Silent_p.F277F|SERPINA1_uc001ycz.3_Silent_p.F277F|SERPINA1_uc010auz.2_Silent_p.F277F|SERPINA1_uc010ava.2_Silent_p.F277F|SERPINA1_uc001ydb.3_Silent_p.F277F|SERPINA1_uc010avb.2_Silent_p.F277F|SERPINA1_uc001ydc.3_Silent_p.F277F|SERPINA1_uc001yda.1_Silent_p.F277F	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	277					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	CATCAGGCAGGAAGAAGATGG	0.488000									Alpha-1-Antitrypsin_Deficiency			
RTL1	388015	broad.mit.edu	37	14	101349151	101349151	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr14:101349151C>T	uc010txj.1	-	1	2034	c.1975G>A	c.(1975-1977)GGA>AGA	p.G659R	uc001yig.3_5'Flank|MIR127_hsa-mir-127|MI0000472_5'Flank|MIR432_hsa-mir-432|MI0003133_5'Flank|uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	659										pancreas(1)	1						CACTCGGCTCCGTGTAACTGG	0.532000												
CCPG1	9236	broad.mit.edu	37	15	55651934	55651934	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr15:55651934C>T	uc002acv.1	-	8	2202	c.2037G>A	c.(2035-2037)CAG>CAA	p.Q679Q	CCPG1_uc002acy.2_Silent_p.Q679Q|CCPG1_uc002acu.1_Silent_p.Q535Q|CCPG1_uc002acw.1_Silent_p.Q404Q|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Silent_p.Q679Q|CCPG1_uc002acz.1_Silent_p.Q679Q	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	679	Lumenal (Potential).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		TATTGATGAACTGATCAAGTT	0.333000												
GTF3C1	2975	broad.mit.edu	37	16	27480772	27480772	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr16:27480772C>T	uc002dov.1	-	32	4954	c.4914G>A	c.(4912-4914)GCG>GCA	p.A1638A	GTF3C1_uc002dou.2_Silent_p.A1638A	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1638						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GGGAGGCTTGCGCAGGTTTCA	0.602000												
SLC9A5	6553	broad.mit.edu	37	16	67293838	67293838	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr16:67293838C>T	uc002esm.2	+	12	1894	c.1831C>T	c.(1831-1833)CCG>TCG	p.P611S	SLC9A5_uc010cee.2_Missense_Mutation_p.P316S|SLC9A5_uc010vji.1_Missense_Mutation_p.P115S|uc002esn.1_5'Flank	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	611					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CCTCTACAAGCCGCGCCGTAG	0.597000												
NQO1	1728	broad.mit.edu	37	16	69745175	69745175	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr16:69745175G>C	uc002exp.2	-	6	720	c.529C>G	c.(529-531)CTG>GTG	p.L177V	NQO1_uc010cfm.2_Missense_Mutation_p.L156V|NQO1_uc002exq.2_Missense_Mutation_p.L143V|NQO1_uc002exr.2_Missense_Mutation_p.L139V|NQO1_uc010vll.1_Missense_Mutation_p.L105V	NM_000903	NP_000894	P15559	NQO1_HUMAN	NAD(P)H menadione oxidoreductase 1,	177					nitric oxide biosynthetic process|regulation of cellular amino acid metabolic process|response to toxin|synaptic transmission, cholinergic|xenobiotic metabolic process	cytosol	coenzyme binding|cytochrome-b5 reductase activity|electron carrier activity|NAD(P)H dehydrogenase (quinone) activity				0					Dicumarol(DB00266)|Menadione(DB00170)	CAGAAATGCAGAATGCCACTC	0.453000												
COG4	25839	broad.mit.edu	37	16	70515668	70515668	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr16:70515668C>T	uc002ezc.2	-	17	2116	c.2105G>A	c.(2104-2106)CGG>CAG	p.R702Q	COG4_uc002eza.2_Missense_Mutation_p.R39Q|COG4_uc002ezb.2_Missense_Mutation_p.R158Q|COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.R681Q|COG4_uc002eze.2_Missense_Mutation_p.R396Q	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	698	D domain.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				TTACCTTACCCGGTTAAAGGT	0.572000												
ANKRD11	29123	broad.mit.edu	37	16	89350371	89350371	+	Missense_Mutation	SNP	G	G	A	rs145730800		TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr16:89350371G>A	uc002fmx.1	-	9	3040	c.2579C>T	c.(2578-2580)TCG>TTG	p.S860L	ANKRD11_uc002fmy.1_Missense_Mutation_p.S860L|ANKRD11_uc002fnc.1_Missense_Mutation_p.S860L|ANKRD11_uc002fnb.1_Missense_Mutation_p.S817L	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	860	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TGTCACTGGCGAGTCCCAGCT	0.537000												
RPA1	6117	broad.mit.edu	37	17	1782886	1782886	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr17:1782886G>A	uc002fto.2	+	11	1100	c.985G>A	c.(985-987)GCC>ACC	p.A329T		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	329					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						CTATGAAGACGCCACTAAAAT	0.488000								NER				
NUP88	4927	broad.mit.edu	37	17	5312217	5312217	+	Silent	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr17:5312217G>A	uc002gbo.1	-	5	719	c.693C>T	c.(691-693)ACC>ACT	p.T231T	NUP88_uc010vsx.1_Silent_p.T231T|NUP88_uc010cle.1_Silent_p.T230T|NUP88_uc010vsy.1_Silent_p.T231T	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	231					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						CTAGAGATGCGGTATACGCCC	0.323000												
TP53	7157	broad.mit.edu	37	17	7578526	7578526	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr17:7578526C>A	uc002gim.2	-	5	598	c.404G>T	c.(403-405)TGC>TTC	p.C135F	TP53_uc002gig.1_Missense_Mutation_p.C135F|TP53_uc002gih.2_Missense_Mutation_p.C135F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C3F|TP53_uc010cng.1_Missense_Mutation_p.C3F|TP53_uc002gii.1_Missense_Mutation_p.C3F|TP53_uc010cnh.1_Missense_Mutation_p.C135F|TP53_uc010cni.1_Missense_Mutation_p.C135F|TP53_uc002gij.2_Missense_Mutation_p.C135F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C42F|TP53_uc002gio.2_Missense_Mutation_p.C3F|TP53_uc010vug.1_Missense_Mutation_p.C96F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	135	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> S (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation; decreased E6-mediated binding to E6-AP).|C -> T (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C135Y(51)|p.C135F(34)|p.C135W(19)|p.C135S(10)|p.C135fs*35(9)|p.0?(7)|p.C135*(7)|p.C135G(6)|p.C135R(6)|p.C135C(5)|p.C135fs*14(2)|p.N131fs*27(2)|p.F134_T140>S(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.C135T(1)|p.V73fs*9(1)|p.C135fs*36(1)|p.C135fs*15(1)|p.Y126fs*11(1)|p.C135_A138delCQLA(1)|p.C42Y(1)|p.C3Y(1)|p.M133fs*13(1)|p.C135_T140delCQLAKT(1)|p.Q136fs*13(1)|p.C135_Q136insXXXXXX(1)|p.C135_Q136insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCAGTTGGCAAAACATCTT	0.572000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
KDM6B	23135	broad.mit.edu	37	17	7748912	7748912	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr17:7748912C>T	uc002giw.1	+	4	416	c.40C>T	c.(40-42)CGG>TGG	p.R14W	KDM6B_uc002gix.2_5'Flank	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	14					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CCGCGCTGCACGGGAAGCCTT	0.642000												
MMP28	79148	broad.mit.edu	37	17	34093640	34093640	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr17:34093640C>T	uc002hjy.1	-	10	1701	c.1442G>A	c.(1441-1443)CGA>CAA	p.R481Q	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	481	Hemopexin-like 4.				proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GCGGTCATCTCGGAAGAAGAT	0.672000												
CCL5	6352	broad.mit.edu	37	17	34199417	34199417	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr17:34199417C>G	uc002hkf.2	-	3	308	c.240G>C	c.(238-240)TGG>TGC	p.W80C		NM_002985	NP_002976	P13501	CCL5_HUMAN	small inducible cytokine A5 precursor	80					activation of phospholipase D activity|cell-cell signaling|cellular protein complex assembly|chemokine-mediated signaling pathway|dendritic cell chemotaxis|eosinophil chemotaxis|immune response|leukocyte cell-cell adhesion|macrophage chemotaxis|negative regulation of T cell apoptosis|negative regulation of viral genome replication|neutrophil activation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell-cell adhesion mediated by integrin|positive regulation of homotypic cell-cell adhesion|positive regulation of innate immune response|positive regulation of macrophage chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of T cell apoptosis|positive regulation of T cell chemotaxis|positive regulation of T cell proliferation|positive regulation of translational initiation|positive regulation of tyrosine phosphorylation of STAT protein|positive regulation of viral genome replication|protein tetramerization|regulation of chronic inflammatory response|response to virus	extracellular space	CCR1 chemokine receptor binding|CCR4 chemokine receptor binding|CCR5 chemokine receptor binding|chemoattractant activity|chemokine activity|chemokine receptor antagonist activity|protein homodimerization activity|protein self-association|receptor signaling protein tyrosine kinase activator activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0183)		ACTCCCGAACCCATTTCTTCT	0.502000												
ACLY	47	broad.mit.edu	37	17	40049326	40049326	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr17:40049326G>A	uc002hyg.2	-	15	1724	c.1561C>T	c.(1561-1563)CGA>TGA	p.R521*	ACLY_uc002hyh.2_Nonsense_Mutation_p.R511*|ACLY_uc002hyi.2_Nonsense_Mutation_p.R575*|ACLY_uc010wfx.1_Nonsense_Mutation_p.R565*|ACLY_uc010wfy.1_Nonsense_Mutation_p.R250*	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	521					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				GGCTCGTCTCGGGAGCAGACA	0.557000												
DHX58	79132	broad.mit.edu	37	17	40261296	40261296	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr17:40261296G>A	uc002hyw.3	-	6	893	c.670C>T	c.(670-672)CGC>TGC	p.R224C	DHX58_uc002hyv.3_RNA|DHX58_uc010wgf.1_Missense_Mutation_p.R217C	NM_024119	NP_077024	Q96C10	DHX58_HUMAN	RNA helicase LGP2	224					innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding				0		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		ACCTGGCTGCGCCTGTGGCAG	0.398000												
RUNDC1	146923	broad.mit.edu	37	17	41141403	41141403	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr17:41141403G>A	uc002ici.1	+	3	715	c.703G>A	c.(703-705)GAG>AAG	p.E235K	RUNDC1_uc010whi.1_Missense_Mutation_p.E5K	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	235	Potential.										0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		GAATCTGAATGAGGACATCAG	0.458000												
PTPRM	5797	broad.mit.edu	37	18	7567872	7567872	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr18:7567872C>T	uc002knn.3	+	1	559	c.56C>T	c.(55-57)GCG>GTG	p.A19V	PTPRM_uc010dkv.2_Missense_Mutation_p.A19V	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	19					homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CTAACTGCGGCGGGCGAGACG	0.388000												
PTPRM	5797	broad.mit.edu	37	18	8069752	8069752	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr18:8069752G>A	uc002knn.3	+	8	1704	c.1201G>A	c.(1201-1203)GAG>AAG	p.E401K	PTPRM_uc010dkv.2_Missense_Mutation_p.E401K|PTPRM_uc010wzl.1_Missense_Mutation_p.E188K	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	401	Fibronectin type-III 2.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				TATCCGCTGGGAGCCATTTGG	0.418000												
NPC1	4864	broad.mit.edu	37	18	21124448	21124448	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr18:21124448C>T	uc002kum.3	-	13	2264	c.1990G>A	c.(1990-1992)GTG>ATG	p.V664M	NPC1_uc010xaz.1_Missense_Mutation_p.V397M|NPC1_uc010xba.1_Missense_Mutation_p.V509M	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	664	SSD.|Helical; (Potential).		V -> M (in NPC1).		autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GAGCTCAGCACGATCAAGATG	0.532000												
ZNF521	25925	broad.mit.edu	37	18	22805849	22805849	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr18:22805849G>A	uc002kvk.2	-	4	2280	c.2033C>T	c.(2032-2034)TCC>TTC	p.S678F	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.S678F|ZNF521_uc002kvl.2_Missense_Mutation_p.S458F	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	678	C2H2-type 15.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CTTCAGCAAGGATTCTTGGTT	0.423000			T	PAX5	ALL							
ZNF397OS	100101467	broad.mit.edu	37	18	32834016	32834016	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr18:32834016C>G	uc002kym.2	-	4	1111	c.883G>C	c.(883-885)GAC>CAC	p.D295H	ZNF397_uc010dmq.2_Intron|ZNF397_uc010dmr.2_Intron|ZNF397_uc002kyj.2_Intron|ZNF397OS_uc002kyl.2_5'Flank|ZNF397OS_uc010xce.1_Missense_Mutation_p.D295H	NM_001112734	NP_001106205	Q86W11	ZSC30_HUMAN	zinc finger protein 397 opposite strand	295					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TCCCTAGTGTCAACGCTCTGT	0.428000												
KIAA1632	57724	broad.mit.edu	37	18	43438665	43438665	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr18:43438665C>T	uc002lbm.2	-	41	7192	c.7092G>A	c.(7090-7092)CAG>CAA	p.Q2364Q	KIAA1632_uc010xcq.1_Silent_p.Q918Q|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Silent_p.Q1239Q	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	2364					autophagy						0						TGAGGCACTCCTGCAGGAACT	0.468000												
C3	718	broad.mit.edu	37	19	6712411	6712411	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr19:6712411C>G	uc002mfm.2	-	11	1188	c.1126G>C	c.(1126-1128)GTG>CTG	p.V376L		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	376					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GGGTTCGTCACGAACACCTGT	0.657000												
VAV1	7409	broad.mit.edu	37	19	6833745	6833745	+	Splice_Site	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr19:6833745G>A	uc002mfu.1	+	18	1828	c.1731_splice	c.e18+1	p.K577_splice	VAV1_uc010xjh.1_Splice_Site_p.K545_splice|VAV1_uc010dva.1_Splice_Site_p.K577_splice|VAV1_uc002mfv.1_Splice_Site_p.K522_splice	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						TATGAAGAAGGTAAGACTTTC	0.542000												
CCDC151	115948	broad.mit.edu	37	19	11545634	11545634	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr19:11545634G>T	uc002mrs.2	-	1	347	c.204C>A	c.(202-204)CAC>CAA	p.H68Q	CCDC151_uc010dxz.2_Missense_Mutation_p.H68Q|PRKCSH_uc002mrt.2_5'Flank|PRKCSH_uc002mru.2_5'Flank|PRKCSH_uc010xlz.1_5'Flank|PRKCSH_uc010dya.2_5'Flank|PRKCSH_uc002mrv.1_5'Flank|PRKCSH_uc010dyb.2_5'Flank	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	68										ovary(1)	1						CCACCTGAGAGTGCACAGAGG	0.567000											OREG0025257	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
MEF2B	100271849	broad.mit.edu	37	19	19261546	19261546	+	Translation_Start_Site	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr19:19261546G>A	uc002nlm.2	-	2	113	c.-1C>T	c.(-3-1)GACGA>GATGA		MEF2B_uc002nln.2_Missense_Mutation_p.T47M|MEF2B_uc002nll.2_Translation_Start_Site|LOC729991-MEF2B_uc010xqo.1_Translation_Start_Site|LOC729991-MEF2B_uc010xqp.1_Translation_Start_Site|LOC729991-MEF2B_uc002nlo.2_Translation_Start_Site|LOC729991-MEF2B_uc002nlp.2_Translation_Start_Site|MEF2B_uc002nlk.2_Translation_Start_Site	NM_001145785	NP_001139257			myocyte enhancer factor 2B isoform a											skin(1)	1			OV - Ovarian serous cystadenocarcinoma(5;0.00011)|Epithelial(12;0.00412)			CCTCCCCATCGTCCCAGGCTG	0.557000												
ZNF208	7757	broad.mit.edu	37	19	22156661	22156661	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr19:22156661G>T	uc002nqp.2	-	4	1324	c.1175C>A	c.(1174-1176)ACT>AAT	p.T392N	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTTCTCTCCAGTATGAATTTT	0.388000												
HNRNPL	3191	broad.mit.edu	37	19	39321782	39321782	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr19:39321782C>T	uc002ojj.1	-	7	992	c.912G>A	c.(910-912)AAG>AAA	p.K304K	ECH1_uc002oji.2_Silent_p.K95K|ECH1_uc010xuk.1_Silent_p.K95K|HNRNPL_uc010ege.1_Intron	NM_001005335	NP_001005335	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	Error:Variant_position_missing_in_P14866_after_alignment					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			CTCTCGAAATCTTGTTGAAGC	0.537000												
GRIK5	2901	broad.mit.edu	37	19	42558546	42558546	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr19:42558546C>T	uc002osj.1	-	8	1017	c.982G>A	c.(982-984)GGT>AGT	p.G328S	GRIK5_uc010eib.1_Missense_Mutation_p.G247S	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	328	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GGCTTCACACCGATCTCCTGG	0.652000												
CCDC61	729440	broad.mit.edu	37	19	46498688	46498688	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr19:46498688A>G	uc002pdw.2	+	2	86	c.86A>G	c.(85-87)GAG>GGG	p.E29G		NM_001080402	NP_001073871			coiled-coil domain containing 61											ovary(1)	1		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00221)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.164)		ATCAGAAGCGAGAACGCCGGA	0.612000												
CHMP2A	27243	broad.mit.edu	37	19	59065483	59065483	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr19:59065483G>A	uc002qti.2	-	1	523	c.97C>T	c.(97-99)CGA>TGA	p.R33*	CHMP2A_uc002qtj.2_Nonsense_Mutation_p.R33*|CHMP2A_uc002qtk.2_Nonsense_Mutation_p.R33*	NM_198426	NP_940818	O43633	CHM2A_HUMAN	chromatin modifying protein 2A	33	Potential.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		AGTTTCTGTCGCTCGCGGTCC	0.582000												
PPM1B	5495	broad.mit.edu	37	2	44428441	44428441	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr2:44428441G>C	uc002rtt.2	+	2	531	c.103G>C	c.(103-105)GAA>CAA	p.E35Q	PPM1B_uc002rts.2_Missense_Mutation_p.E35Q|PPM1B_uc002rtu.2_Missense_Mutation_p.E35Q|PPM1B_uc002rtv.2_Intron|PPM1B_uc002rtw.2_Missense_Mutation_p.E35Q|PPM1B_uc002rtx.2_Missense_Mutation_p.E35Q	NM_002706	NP_002697	O75688	PPM1B_HUMAN	protein phosphatase 1B isoform 1	35					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ATGGAGAGTGGAAATGGAAGA	0.463000												
PROM2	150696	broad.mit.edu	37	2	95952270	95952270	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr2:95952270G>A	uc002suh.1	+	17	2124	c.1991G>A	c.(1990-1992)GGA>GAA	p.G664E	PROM2_uc002sui.2_Missense_Mutation_p.G664E|PROM2_uc002suj.2_Missense_Mutation_p.G318E|PROM2_uc002suk.2_Missense_Mutation_p.G664E|PROM2_uc002sul.2_Missense_Mutation_p.G190E|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	664	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						GAGGCCCAAGGACTCAGAAAC	0.627000												
LONRF2	164832	broad.mit.edu	37	2	100912008	100912008	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr2:100912008G>T	uc002tal.3	-	8	2124	c.1484C>A	c.(1483-1485)GCA>GAA	p.A495E	LONRF2_uc010yvs.1_RNA	NM_198461	NP_940863	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger	495					proteolysis		ATP-dependent peptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2						GTTTCTGCTTGCCAATAACTG	0.368000												
DPP10	57628	broad.mit.edu	37	2	116538567	116538567	+	Silent	SNP	T	T	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr2:116538567T>C	uc002tla.1	+	16	1936	c.1479T>C	c.(1477-1479)TGT>TGC	p.C493C	DPP10_uc002tlb.1_Silent_p.C443C|DPP10_uc002tlc.1_Silent_p.C489C|DPP10_uc002tle.2_Silent_p.C497C|DPP10_uc002tlf.1_Silent_p.C486C	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	493	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						TATTATTCTGTGAAGGTAAGA	0.279000												
KCNJ3	3760	broad.mit.edu	37	2	155566118	155566118	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr2:155566118C>T	uc002tyv.1	+	2	901	c.706C>T	c.(706-708)CGG>TGG	p.R236W	KCNJ3_uc010zce.1_Intron	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	236	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	TGTCTAGTCTCGGCAGACACC	0.453000												
SCN1A	6323	broad.mit.edu	37	2	166847826	166847826	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr2:166847826C>T	uc010zcz.1	-	26	5944	c.5926G>A	c.(5926-5928)GAC>AAC	p.D1976N		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1987						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GTCACCCGGTCATAGGAAGGT	0.343000												
XIRP2	129446	broad.mit.edu	37	2	168100087	168100087	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr2:168100087G>T	uc002udx.2	+	8	2203	c.2185G>T	c.(2185-2187)GTT>TTT	p.V729F	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.V554F|XIRP2_uc010fpq.2_Missense_Mutation_p.V507F|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	554	Xin 6.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TAAGGGAAATGTTAAAAGAAG	0.363000												
TTN	7273	broad.mit.edu	37	2	179482993	179482993	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr2:179482993C>T	uc010zfg.1	-	201	39712	c.39488G>A	c.(39487-39489)CGT>CAT	p.R13163H	TTN_uc010zfh.1_Missense_Mutation_p.R6858H|TTN_uc010zfi.1_Missense_Mutation_p.R6791H|TTN_uc010zfj.1_Missense_Mutation_p.R6666H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14090							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCACTCACACGGAATAGGTA	0.438000												
ADAM23	8745	broad.mit.edu	37	2	207429756	207429756	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr2:207429756C>A	uc002vbq.2	+	14	1581	c.1358C>A	c.(1357-1359)ACA>AAA	p.T453K	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	453	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TGTGACTGCACAGAATCCTGG	0.353000												
TGM6	343641	broad.mit.edu	37	20	2384268	2384268	+	Missense_Mutation	SNP	G	G	A	rs148470870	byFrequency	TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr20:2384268G>A	uc002wfy.1	+	9	1196	c.1135G>A	c.(1135-1137)GAG>AAG	p.E379K	TGM6_uc010gal.1_Missense_Mutation_p.E379K	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	379					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CGCCATCCGCGAGGGTGATGT	0.637000												
COMMD7	149951	broad.mit.edu	37	20	31291840	31291840	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr20:31291840C>T	uc002wya.3	-	8	1128	c.511G>A	c.(511-513)GAA>AAA	p.E171K	COMMD7_uc010ged.2_Missense_Mutation_p.E170K|COMMD7_uc002wyb.2_Missense_Mutation_p.E171K	NM_053041	NP_444269	Q86VX2	COMD7_HUMAN	COMM domain containing 7 isoform 1	171	COMM.			E -> K (in Ref. 1; AAS22244 and 5; AAH47440).	negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|tumor necrosis factor-mediated signaling pathway		NF-kappaB binding			breast(1)	1						TACACATTTTCGGTTTGATTT	0.368000												
DLGAP4	22839	broad.mit.edu	37	20	35060202	35060202	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr20:35060202G>A	uc002xff.2	+	3	517	c.82G>A	c.(82-84)GAC>AAC	p.D28N	DLGAP4_uc010zvp.1_Missense_Mutation_p.D28N	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	28					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				TGCAGGGACCGACCGCAACCC	0.697000												
SALL4	57167	broad.mit.edu	37	20	50407885	50407885	+	Silent	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr20:50407885G>A	uc002xwh.3	-	2	1238	c.1137C>T	c.(1135-1137)CTC>CTT	p.L379L	SALL4_uc010gii.2_Silent_p.L379L|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	379					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TGTGCTTGTAGAGGGCCGCCT	0.552000												
SPO11	23626	broad.mit.edu	37	20	55918512	55918512	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr20:55918512T>C	uc002xye.2	+	13	1280	c.1187T>C	c.(1186-1188)ATA>ACA	p.I396T	SPO11_uc002xyf.2_Missense_Mutation_p.I358T	NM_012444	NP_036576	Q9Y5K1	SPO11_HUMAN	meiotic recombination protein SPO11 isoform a	396					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			GGAGGATGGATATAAAAATAA	0.303000								Editing_and_processing_nucleases				
GNAS	2778	broad.mit.edu	37	20	57430185	57430185	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr20:57430185G>A	uc002xzw.2	+	1	2150	c.1865G>A	c.(1864-1866)CGA>CAA	p.R622Q	GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			TGCTTCGGTCGATCTGAGAGT	0.612000			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)		
LAMA5	3911	broad.mit.edu	37	20	60907448	60907448	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr20:60907448C>T	uc002ycq.2	-	28	3599	c.3532G>A	c.(3532-3534)GAA>AAA	p.E1178K		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1178	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGTGCCTGTTCGGCTGTGAGC	0.622000												
EEF1A2	1917	broad.mit.edu	37	20	62126392	62126392	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr20:62126392C>T	uc002yfd.1	-	3	488	c.387G>A	c.(385-387)AAG>AAA	p.K129K	EEF1A2_uc002yfe.1_Silent_p.K129K|EEF1A2_uc010gkg.1_Silent_p.K129K	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	129						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			TCTGCCCATTCTTGGAGATGC	0.672000												
C20orf135	140701	broad.mit.edu	37	20	62493340	62493340	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr20:62493340C>G	uc002ygx.1	+	1	775	c.447C>G	c.(445-447)GAC>GAG	p.D149E		NM_080622	NP_542189	Q9H3Z7	ABHGB_HUMAN	hypothetical protein LOC140701	149							hydrolase activity				0	all_cancers(38;1.77e-12)|all_epithelial(29;3.12e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					TGGCCTGTGACGGCAACGAGA	0.701000												
TPTE	7179	broad.mit.edu	37	21	10970031	10970031	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr21:10970031C>T	uc002yip.1	-	6	465	c.97G>A	c.(97-99)GAG>AAG	p.E33K	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.E33K|TPTE_uc002yir.1_Missense_Mutation_p.E33K|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	33					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGTGCCTCCTCGGTTGCTCCT	0.393000												
RUNX1	861	broad.mit.edu	37	21	36171641	36171641	+	Silent	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr21:36171641G>A	uc002yuh.2	-	5	2421	c.843C>T	c.(841-843)AGC>AGT	p.S281S	RUNX1_uc002yui.2_Silent_p.S217S|RUNX1_uc010gmu.2_Silent_p.S308S|RUNX1_uc010gmv.2_Silent_p.S308S|RUNX1_uc002yuj.3_Silent_p.S176S|RUNX1_uc002yuk.3_Silent_p.S308S|RUNX1_uc002yul.1_Silent_p.S73S|RUNX1_uc002yum.1_Silent_p.S112S	NM_001001890	NP_001001890	Q01196	RUNX1_HUMAN	runt-related transcription factor 1 isoform	281	Pro/Ser/Thr-rich.			Missing: No DNA-binding.	myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus|nucleus	ATP binding|calcium ion binding|DNA binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.Y281*(1)		haematopoietic_and_lymphoid_tissue(383)|lung(2)|ovary(1)|central_nervous_system(1)	387						TTGTCATGCCGCTGGCACGTC	0.547000			T	RPL22|MDS1|EVI1|CBFA2T3|CBFA2T1|ETV6|LAF4	AML|preB- ALL|T-ALL				Platelet_disorder_associated_with_Myeloid_Malignancies			
DSCAM	1826	broad.mit.edu	37	21	41710048	41710048	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr21:41710048C>T	uc002yyq.1	-	8	2215	c.1763G>A	c.(1762-1764)AGC>AAC	p.S588N	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	588	Extracellular (Potential).|Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CACGTGGACGCTCTGGCTGGT	0.502000												
C22orf31	25770	broad.mit.edu	37	22	29456681	29456681	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr22:29456681T>C	uc003aej.1	-	2	281	c.154A>G	c.(154-156)AAT>GAT	p.N52D		NM_015370	NP_056185	O95567	CV031_HUMAN	hypothetical protein LOC25770	52											0						GCTGGGGCATTAATGTTCTGC	0.488000												
SSTR3	6753	broad.mit.edu	37	22	37602944	37602944	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr22:37602944G>A	uc003ara.2	-	2	961	c.899C>T	c.(898-900)GCG>GTG	p.A300V	SSTR3_uc003arb.2_Missense_Mutation_p.A300V	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	300	Helical; Name=7; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						ATAGGGCAGCGCCACCACCAG	0.622000												
ITGA9	3680	broad.mit.edu	37	3	37845379	37845379	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr3:37845379C>T	uc003chd.2	+	27	3008	c.2955C>T	c.(2953-2955)ATC>ATT	p.I985I		NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	985	Helical; (Potential).				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TCATCGCCATCAGTTTGTTGG	0.557000												
CCDC13	152206	broad.mit.edu	37	3	42788762	42788762	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr3:42788762C>T	uc003cly.3	-	6	791	c.707G>A	c.(706-708)CGG>CAG	p.R236Q	CCDC13_uc003clz.2_Missense_Mutation_p.R236Q|CCDC13_uc011azq.1_3'UTR	NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	236	Potential.									ovary(1)	1						CTGTGCCATCCGCAGCTCCTG	0.592000												
KLHL18	23276	broad.mit.edu	37	3	47378200	47378200	+	Silent	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr3:47378200G>A	uc003crd.2	+	7	1200	c.1074G>A	c.(1072-1074)CCG>CCA	p.P358P	KLHL18_uc003crc.2_Silent_p.P358P|KLHL18_uc011bav.1_Silent_p.P246P|KLHL18_uc010hjq.1_Silent_p.P214P	NM_025010	NP_079286	O94889	KLH18_HUMAN	kelch-like 18	358	Kelch 2.										0		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		CCTACAACCCGGAGACAGACA	0.597000												
MAP4	4134	broad.mit.edu	37	3	47913507	47913507	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr3:47913507C>A	uc003csb.2	-	11	2932	c.2406G>T	c.(2404-2406)AAG>AAT	p.K802N	MAP4_uc003csc.3_Missense_Mutation_p.K802N|MAP4_uc003crw.2_5'Flank|MAP4_uc003crx.2_Missense_Mutation_p.K62N|MAP4_uc011bbe.1_Missense_Mutation_p.K553N|MAP4_uc003cry.2_Missense_Mutation_p.K537N|MAP4_uc003csa.3_Missense_Mutation_p.K537N|MAP4_uc003crz.3_RNA|MAP4_uc003csd.2_Missense_Mutation_p.K537N	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	802					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TCTGAGTGCTCTTGGACCCAG	0.577000												
C3orf63	23272	broad.mit.edu	37	3	56657367	56657367	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr3:56657367T>C	uc003did.3	-	23	4629	c.4528A>G	c.(4528-4530)AGA>GGA	p.R1510G	C3orf63_uc003dib.3_Missense_Mutation_p.R629G|C3orf63_uc003dic.3_Missense_Mutation_p.R1134G|C3orf63_uc003die.3_3'UTR	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	1571										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		ATAGAAGTTCTCTCTTCAGAA	0.318000												
PROS1	5627	broad.mit.edu	37	3	93646135	93646135	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr3:93646135T>C	uc003drb.3	-	2	534	c.193A>G	c.(193-195)AAA>GAA	p.K65E	PROS1_uc010hoo.2_Translation_Start_Site|PROS1_uc003dqz.3_Translation_Start_Site	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	65	Gla.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	GCTTCTTCTTTATTGCACAGT	0.413000												
EPHB1	2047	broad.mit.edu	37	3	134851754	134851754	+	Missense_Mutation	SNP	C	C	T	rs56396912		TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr3:134851754C>T	uc003eqt.2	+	5	1380	c.1160C>T	c.(1159-1161)ACG>ATG	p.T387M	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_3'UTR|EPHB1_uc003equ.2_Translation_Start_Site	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	387	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.T387M(4)|p.T387T(1)		lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CTGGGCCTGACGGAGTGCCGC	0.612000												
NLGN1	22871	broad.mit.edu	37	3	173322864	173322864	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr3:173322864A>G	uc003fio.1	+	3	899	c.476A>G	c.(475-477)TAT>TGT	p.Y159C	NLGN1_uc010hww.1_Missense_Mutation_p.Y159C|NLGN1_uc003fip.1_Missense_Mutation_p.Y159C	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	159	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TTAAATATATATGTCCCGACT	0.343000												
SPON2	10417	broad.mit.edu	37	4	1165840	1165840	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr4:1165840G>A	uc003gcn.3	-	1	47	c.20C>T	c.(19-21)GCC>GTC	p.A7V	SPON2_uc003gco.3_Missense_Mutation_p.A7V|SPON2_uc010ibr.2_Missense_Mutation_p.A7V|SPON2_uc003gcm.1_5'Flank	NM_012445	NP_036577	Q9BUD6	SPON2_HUMAN	spondin 2, extracellular matrix protein	7					axon guidance|cell adhesion|innate immune response	proteinaceous extracellular matrix	metal ion binding			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00805)	UCEC - Uterine corpus endometrioid carcinoma (64;0.139)|Colorectal(103;0.19)		CAGGGCGGCGGCCGGGCTGGG	0.726000												
FAM53A	152877	broad.mit.edu	37	4	1656730	1656730	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr4:1656730G>A	uc011bve.1	-	4	1055	c.857C>T	c.(856-858)TCC>TTC	p.S286F	FAM53A_uc010ibw.2_Missense_Mutation_p.S286F	NM_001013622	NP_001013644	Q6NSI3	FA53A_HUMAN	dorsal neural-tube nuclear protein	286						nucleus					0		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			GAAGTCCAAGGATGGGCGTGT	0.637000												
LAP3	51056	broad.mit.edu	37	4	17609194	17609194	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr4:17609194C>T	uc003gph.1	+	13	1704	c.1542C>T	c.(1540-1542)TTC>TTT	p.F514F		NM_015907	NP_056991	P28838	AMPL_HUMAN	leucine aminopeptidase 3	514					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding				0						TACTTCGTTTCAGTCAAGACA	0.393000												
NCAPG	64151	broad.mit.edu	37	4	17814759	17814759	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr4:17814759G>C	uc003gpp.2	+	3	711	c.535G>C	c.(535-537)GTG>CTG	p.V179L	NCAPG_uc011bxj.1_5'UTR|DCAF16_uc003gpn.2_5'Flank	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	179	HEAT 3.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		TGAATGCCCAGTGGTTAATGG	0.318000												
PCDH7	5099	broad.mit.edu	37	4	31144151	31144151	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr4:31144151G>A	uc011bxx.1	+	3	4432	c.3424G>A	c.(3424-3426)GAG>AAG	p.E1142K	PCDH7_uc011bxw.1_Missense_Mutation_p.E1095K	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	Error:Variant_position_missing_in_O60245_after_alignment					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						TGAGTGTGATGAGTATGGCCA	0.507000												
ARAP2	116984	broad.mit.edu	37	4	36069743	36069743	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr4:36069743T>G	uc003gsq.1	-	33	5239	c.4901A>C	c.(4900-4902)AAC>ACC	p.N1634T	ARAP2_uc003gso.2_Intron	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1634					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CTCCAGGCAGTTGAAACTCCG	0.512000												
EPHA5	2044	broad.mit.edu	37	4	66467877	66467877	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr4:66467877T>G	uc003hcy.2	-	3	585	c.392A>C	c.(391-393)AAA>ACA	p.K131T	EPHA5_uc003hcx.2_Missense_Mutation_p.K62T|EPHA5_uc003hcz.2_Missense_Mutation_p.K131T|EPHA5_uc011cah.1_Missense_Mutation_p.K131T|EPHA5_uc011cai.1_Missense_Mutation_p.K131T|EPHA5_uc003hda.2_Missense_Mutation_p.K131T	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	131	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CAGGGTAAATTTGAGTTCTAT	0.428000										TSP Lung(17;0.13)		
BMP2K	55589	broad.mit.edu	37	4	79793071	79793071	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr4:79793071C>T	uc003hlk.2	+	12	1743	c.1577C>T	c.(1576-1578)CCA>CTA	p.P526L	BMP2K_uc003hlj.2_Missense_Mutation_p.P526L|BMP2K_uc003hll.2_5'Flank	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	526	Gln/His-rich.					nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						GTATATCAACCACAACCTTCT	0.323000												
UNC5C	8633	broad.mit.edu	37	4	96127903	96127903	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr4:96127903C>A	uc003htp.1	-	11	1932	c.1778G>T	c.(1777-1779)AGC>ATC	p.S593I	UNC5C_uc010ilc.1_Missense_Mutation_p.S612I	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	593	Cytoplasmic (Potential).|ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GGGCCCACAGCTCACCACAGG	0.532000												
METTL14	57721	broad.mit.edu	37	4	119618350	119618350	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr4:119618350G>A	uc003icf.2	+	7	633	c.517G>A	c.(517-519)GAT>AAT	p.D173N	METTL14_uc003icg.2_Missense_Mutation_p.D135N	NM_020961	NP_066012	Q9HCE5	MTL14_HUMAN	methyltransferase like 14	173						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity				0						CTTACAAGCCGATATAGAAGC	0.323000												
MFAP3L	9848	broad.mit.edu	37	4	170913336	170913336	+	Silent	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr4:170913336G>A	uc003isp.3	-	3	601	c.423C>T	c.(421-423)CGC>CGT	p.R141R	MFAP3L_uc003isn.3_Silent_p.R38R	NM_021647	NP_067679	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like isoform	141	Extracellular (Potential).|Ig-like C2-type.					integral to membrane|plasma membrane				ovary(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		TGAAGATGACGCGCAAGGTCA	0.527000												
ODZ3	55714	broad.mit.edu	37	4	183696162	183696162	+	Silent	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr4:183696162G>A	uc003ivd.1	+	23	5197	c.5160G>A	c.(5158-5160)CCG>CCA	p.P1720P		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1720	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AAACAGAGCCGCACGTTCTGG	0.493000												
TERT	7015	broad.mit.edu	37	5	1264673	1264673	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr5:1264673C>T	uc003jcb.1	-	11	2747	c.2689G>A	c.(2689-2691)GTG>ATG	p.V897M	TERT_uc003jbz.1_Missense_Mutation_p.V93M|TERT_uc003jca.1_Missense_Mutation_p.V885M|TERT_uc003jcc.1_Intron|TERT_uc003jcd.1_Intron|TERT_uc003jce.1_Intron	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	897	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			AAGTTCACCACGCAGCCATAC	0.622000									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic			
KIAA0947	23379	broad.mit.edu	37	5	5461956	5461956	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr5:5461956C>T	uc003jdm.3	+	13	2731	c.2509C>T	c.(2509-2511)CTT>TTT	p.L837F		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	837										ovary(1)|central_nervous_system(1)	2						CAAGCCTGATCTTCTTAGAGA	0.403000												
DNAH5	1767	broad.mit.edu	37	5	13754330	13754330	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr5:13754330G>A	uc003jfd.2	-	62	10579	c.10537C>T	c.(10537-10539)CAA>TAA	p.Q3513*	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3513					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTTTTAGTTTGTGCAGCAAAC	0.393000									Kartagener_syndrome			
CCNH	902	broad.mit.edu	37	5	86700776	86700776	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr5:86700776C>T	uc003kjb.2	-	5	806	c.574G>A	c.(574-576)GAT>AAT	p.D192N	CCNH_uc003kiy.1_Intron|CCNH_uc003kiz.1_Missense_Mutation_p.D139N|CCNH_uc003kja.2_Missense_Mutation_p.D139N	NM_001239	NP_001230	P51946	CCNH_HUMAN	cyclin H	192					G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cyclin-dependent protein kinase activating kinase holoenzyme complex|holo TFIIH complex	protein kinase binding			ovary(2)|kidney(1)	3		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;9.01e-39)|Epithelial(54;5.08e-33)|all cancers(79;4.28e-28)		AGAAAGTCATCAGCTGTTTTC	0.408000								Direct_reversal_of_damage|NER				
SRFBP1	153443	broad.mit.edu	37	5	121356468	121356468	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr5:121356468C>T	uc003kst.1	+	6	1110	c.1038C>T	c.(1036-1038)CAC>CAT	p.H346H		NM_152546	NP_689759	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm					0		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		TGTTTTTCCACTCTTTATCTG	0.313000												
PCDHB6	56130	broad.mit.edu	37	5	140530019	140530019	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr5:140530019C>T	uc003lir.2	+	1	181	c.181C>T	c.(181-183)CGG>TGG	p.R61W	PCDHB6_uc011dah.1_Intron	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	61	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGGCTTCGCGGGGCGCTCG	0.507000												
PCDHGA3	56112	broad.mit.edu	37	5	140725213	140725213	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr5:140725213G>A	uc003ljm.1	+	1	1613	c.1613G>A	c.(1612-1614)GGG>GAG	p.G538E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.G298E|PCDHGA3_uc011dap.1_Missense_Mutation_p.G538E	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	538	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGACAGCGGGAACCCTCCA	0.572000												
PCDHGA6	56109	broad.mit.edu	37	5	140755983	140755983	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr5:140755983C>T	uc003ljy.1	+	1	2333	c.2333C>T	c.(2332-2334)ACG>ATG	p.T778M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.T778M	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	778	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATGCCGACACGCTTATCAAC	0.507000												
CSF1R	1436	broad.mit.edu	37	5	149447874	149447874	+	Silent	SNP	C	C	T	rs145267004		TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr5:149447874C>T	uc003lrl.2	-	10	1725	c.1530G>A	c.(1528-1530)CCG>CCA	p.P510P	CSF1R_uc011dcd.1_Silent_p.P362P|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Silent_p.P510P	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	510	Extracellular (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	GGAACTCATCCGGGGGATGCG	0.458000												
DNAH8	1769	broad.mit.edu	37	6	38702323	38702323	+	Silent	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr6:38702323G>A	uc003ooe.1	+	3	633	c.33G>A	c.(31-33)CCG>CCA	p.P11P	DNAH8_uc003ood.1_Silent_p.P228P	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8									p.P11P(1)		skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ATGCAGCCCCGGATAAACTAA	0.353000												
PGC	5225	broad.mit.edu	37	6	41711094	41711094	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr6:41711094G>A	uc003ora.1	-	4	411	c.362C>T	c.(361-363)TCC>TTC	p.S121F		NM_002630	NP_002621	P20142	PEPC_HUMAN	progastricsin (pepsinogen C) precursor	121					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GGAGTAGGTGGACGACTCGCT	0.642000												
CD164	8763	broad.mit.edu	37	6	109691643	109691643	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr6:109691643G>A	uc003pte.2	-	5	579	c.398C>T	c.(397-399)TCT>TTT	p.S133F	CD164_uc003ptd.2_Missense_Mutation_p.S133F|CD164_uc003ptf.2_Intron|CD164_uc011eap.1_Missense_Mutation_p.S133F|CD164_uc010kdn.2_Missense_Mutation_p.S120F	NM_006016	NP_006007	Q04900	MUC24_HUMAN	CD164 molecule, sialomucin isoform 1	133	Thr-rich.|Extracellular (Potential).				hemopoiesis|heterophilic cell-cell adhesion|immune response|muscle organ development|negative regulation of cell adhesion|negative regulation of cell proliferation|signal transduction	endosome membrane|extracellular region|integral to plasma membrane|lysosomal membrane	protein binding				0		all_cancers(87;4.65e-22)|all_epithelial(87;2.54e-20)|all_lung(197;1.6e-05)|Lung NSC(302;2.92e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.0175)		Epithelial(106;7.83e-46)|all cancers(137;1.15e-45)|OV - Ovarian serous cystadenocarcinoma(136;2.89e-26)|BRCA - Breast invasive adenocarcinoma(108;0.00128)|GBM - Glioblastoma multiforme(226;0.16)		GGAAGTTGTAGAAGGGGAGGG	0.378000												
SYNE1	23345	broad.mit.edu	37	6	152642497	152642497	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr6:152642497C>T	uc010kiw.2	-	84	16714	c.16112G>A	c.(16111-16113)CGA>CAA	p.R5371Q	SYNE1_uc003qot.3_Missense_Mutation_p.R5300Q|SYNE1_uc003qou.3_Missense_Mutation_p.R5371Q|SYNE1_uc010kiz.2_Missense_Mutation_p.R1126Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5371	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AATGTTCTGTCGGTGATTTGT	0.393000										HNSCC(10;0.0054)		
ADAP1	11033	broad.mit.edu	37	7	944770	944770	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:944770T>G	uc003sjo.3	-	5	604	c.428A>C	c.(427-429)AAC>ACC	p.N143T	ADAP1_uc003sjm.3_5'UTR|ADAP1_uc011jvs.1_Missense_Mutation_p.N48T|ADAP1_uc003sjn.3_Missense_Mutation_p.N71T|ADAP1_uc010ksc.2_Missense_Mutation_p.N71T	NM_006869	NP_006860	O75689	ADAP1_HUMAN	centaurin, alpha 1	143	PH 1.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			upper_aerodigestive_tract(1)	1						AAACTGCCCGTTGTCCCGGCC	0.562000												
HIBADH	11112	broad.mit.edu	37	7	27672037	27672037	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:27672037C>T	uc003szf.2	-	3	475	c.280G>A	c.(280-282)GAA>AAA	p.E94K	HIBADH_uc003szg.2_Missense_Mutation_p.E45K|HIBADH_uc003szh.2_5'UTR|HIBADH_uc003szi.2_Missense_Mutation_p.E45K	NM_152740	NP_689953	P31937	3HIDH_HUMAN	3-hydroxyisobutyrate dehydrogenase precursor	94					branched chain family amino acid catabolic process|pentose-phosphate shunt|valine metabolic process	mitochondrial matrix	3-hydroxyisobutyrate dehydrogenase activity|NAD binding|phosphogluconate dehydrogenase (decarboxylating) activity			ovary(2)	2			GBM - Glioblastoma multiforme(3;0.0368)		NADH(DB00157)	TCAGCTTTTTCAGCAACATCT	0.363000												
EEPD1	80820	broad.mit.edu	37	7	36194426	36194426	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:36194426C>T	uc003tfa.2	+	2	1133	c.493C>T	c.(493-495)CGC>TGC	p.R165C		NM_030636	NP_085139	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family	165					DNA repair		DNA binding				0						CGTGGACTTCCGCCGTGAGCA	0.607000												
C7orf42	55069	broad.mit.edu	37	7	66410149	66410149	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:66410149A>G	uc003tvk.2	+	3	610	c.346A>G	c.(346-348)ATC>GTC	p.I116V	C7orf42_uc010lah.2_RNA|C7orf42_uc003tvl.2_Missense_Mutation_p.I116V	NM_017994	NP_060464	Q9NWD8	CG042_HUMAN	hypothetical protein LOC55069	116						integral to membrane				ovary(1)	1						CTCAGTCTCAATCACCCTAAC	0.577000												
HGF	3082	broad.mit.edu	37	7	81372669	81372669	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:81372669C>T	uc003uhl.2	-	7	1030	c.865G>A	c.(865-867)GCT>ACT	p.A289T	HGF_uc003uhm.2_Missense_Mutation_p.A284T|HGF_uc003uhn.1_Missense_Mutation_p.E289K|HGF_uc003uho.1_Missense_Mutation_p.E284K	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	289					epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						CTTCACTTACCGCATGTTTTA	0.448000												
MGC26647	219557	broad.mit.edu	37	7	88423644	88423644	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:88423644G>A	uc003ujv.2	-	2	795	c.613C>T	c.(613-615)CCT>TCT	p.P205S	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	205											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			AGTAGGTCAGGTGCAACTTGG	0.408000												
CDHR3	222256	broad.mit.edu	37	7	105658403	105658403	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:105658403G>C	uc003vdl.3	+	12	1646	c.1538G>C	c.(1537-1539)TGG>TCG	p.W513S	CDHR3_uc003vdk.2_Intron|CDHR3_uc003vdm.3_Missense_Mutation_p.W500S|CDHR3_uc011klt.1_Missense_Mutation_p.W425S|CDHR3_uc003vdn.2_Intron	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	513	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						AATGTATTTTGGATTAATCCC	0.512000												
PIK3CG	5294	broad.mit.edu	37	7	106508257	106508257	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:106508257C>T	uc003vdv.3	+	2	336	c.251C>T	c.(250-252)GCG>GTG	p.A84V	PIK3CG_uc003vdu.2_Missense_Mutation_p.A84V|PIK3CG_uc003vdw.2_Missense_Mutation_p.A84V	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	84					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						ACCAGCGTGGCGGCGGACTTC	0.637000												
IMPDH1	3614	broad.mit.edu	37	7	128038597	128038597	+	Silent	SNP	G	G	A	rs1042253		TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:128038597G>A	uc011kol.1	-	7	796	c.690C>T	c.(688-690)AAC>AAT	p.N230N	IMPDH1_uc011kom.1_Silent_p.N225N|IMPDH1_uc003vmt.2_Silent_p.N205N|IMPDH1_uc003vmu.2_Silent_p.N315N|IMPDH1_uc003vmw.2_Silent_p.N305N|IMPDH1_uc011kon.1_Silent_p.N282N|IMPDH1_uc003vmv.2_Silent_p.N279N|IMPDH1_uc003vmx.2_Silent_p.N238N|IMPDH1_uc003vmy.2_Silent_p.N246N	NM_001142573	NP_001136045	P20839	IMDH1_HUMAN	inosine monophosphate dehydrogenase 1 isoform e	230	CBS 2.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			skin(2)|lung(1)|central_nervous_system(1)	4					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	GGTAGTCTCGGTTCTTCTTCA	0.572000											OREG0018292	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
C7orf49	78996	broad.mit.edu	37	7	134852517	134852517	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:134852517C>T	uc003vsl.2	-	3	447	c.180G>A	c.(178-180)GAG>GAA	p.E60E	C7orf49_uc003vsh.2_Intron|C7orf49_uc003vsj.2_Silent_p.E31E|C7orf49_uc003vsk.2_RNA|C7orf49_uc003vsm.2_RNA|C7orf49_uc003vsn.2_Silent_p.E59E|C7orf49_uc003vso.2_Silent_p.E5E	NM_024033	NP_076938	Q9BWK5	MRI_HUMAN	modulator of retrovirus infection	60						cytoplasm				large_intestine(1)|ovary(1)	2						CATCAACTATCTCAGCCTCAT	0.478000												
TAS2R4	50832	broad.mit.edu	37	7	141478883	141478883	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:141478883C>A	uc003vwq.1	+	1	595	c.595C>A	c.(595-597)CTA>ATA	p.L199I		NM_016944	NP_058640	Q9NYW5	TA2R4_HUMAN	taste receptor T2R4	199	Cytoplasmic (Potential).				sensory perception of taste	cilium membrane	taste receptor activity				0	Melanoma(164;0.0171)			BRCA - Breast invasive adenocarcinoma(188;0.196)		TGCTTCCTTGCTAATACACTC	0.423000												
SHH	6469	broad.mit.edu	37	7	155596246	155596246	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:155596246T>C	uc003wmk.1	-	3	888	c.737A>G	c.(736-738)GAC>GGC	p.D246G	SHH_uc003wmh.1_Intron|SHH_uc003wmi.1_Intron|SHH_uc003wmj.1_Missense_Mutation_p.D159G	NM_000193	NP_000184	Q15465	SHH_HUMAN	sonic hedgehog preproprotein	246					androgen metabolic process|axon guidance|branching involved in ureteric bud morphogenesis|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|embryonic digit morphogenesis|hindbrain development|intein-mediated protein splicing|lymphoid progenitor cell differentiation|metanephric mesenchymal cell proliferation involved in metanephros development|midbrain development|negative regulation of cell migration|negative regulation of kidney smooth muscle cell differentiation|negative regulation of ureter smooth muscle cell differentiation|negative thymic T cell selection|neural crest cell migration|neuroblast proliferation|patterning of blood vessels|positive regulation of alpha-beta T cell differentiation|positive regulation of immature T cell proliferation in thymus|positive regulation of kidney smooth muscle cell differentiation|positive regulation of mesenchymal cell proliferation involved in ureter development|positive regulation of T cell differentiation in thymus|positive regulation of ureter smooth muscle cell differentiation|positive thymic T cell selection|proteolysis|sclerotome development|stem cell development|thymus development|vasculogenesis|ventral midline development	cell surface|extracellular space|membrane raft|plasma membrane	calcium ion binding|laminin-1 binding|peptidase activity|signal transducer activity|zinc ion binding			central_nervous_system(3)|lung(1)	4	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00882)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTTGGCGCCGTCGTCGCGGTC	0.687000												
PTPRN2	5799	broad.mit.edu	37	7	157874021	157874021	+	Silent	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:157874021G>A	uc003wno.2	-	11	1813	c.1692C>T	c.(1690-1692)AAC>AAT	p.N564N	PTPRN2_uc003wnp.2_Silent_p.N547N|PTPRN2_uc003wnq.2_Silent_p.N535N|PTPRN2_uc003wnr.2_Silent_p.N526N|PTPRN2_uc011kwa.1_Silent_p.N587N	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	564	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CAGTGGTCACGTTTTGGACAT	0.363000												
RP1	6101	broad.mit.edu	37	8	55534700	55534700	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr8:55534700C>T	uc003xsd.1	+	3	787	c.639C>T	c.(637-639)ATC>ATT	p.I213I	RP1_uc011ldy.1_Silent_p.I213I	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	213	Doublecortin 2.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AGGCAGTGATCCTGAGCTCTG	0.438000												
RP1	6101	broad.mit.edu	37	8	55539117	55539117	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr8:55539117C>T	uc003xsd.1	+	4	2823	c.2675C>T	c.(2674-2676)GCA>GTA	p.A892V	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	892					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACAACCAGGGCAAATTCTTTA	0.333000												
CHD7	55636	broad.mit.edu	37	8	61765949	61765949	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr8:61765949A>G	uc003xue.2	+	31	7142	c.6665A>G	c.(6664-6666)GAG>GGG	p.E2222G		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2222	Glu-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AAAGGTGTTGAGGTCGGCGCA	0.502000												
MTFR1	9650	broad.mit.edu	37	8	66631645	66631645	+	Missense_Mutation	SNP	G	G	A	rs143063031		TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr8:66631645G>A	uc003xvo.1	+	7	1044	c.934G>A	c.(934-936)GTG>ATG	p.V312M	PDE7A_uc003xvq.2_Silent_p.H443H|PDE7A_uc003xvp.2_Silent_p.H417H	NM_014637	NP_055452	Q15390	MTFR1_HUMAN	mitochondrial fission regulator 1 isoform 1	Error:Variant_position_missing_in_Q15390_after_alignment						mitochondrion|plasma membrane				pancreas(1)	1			Epithelial(68;0.0526)|BRCA - Breast invasive adenocarcinoma(89;0.156)|all cancers(69;0.171)|OV - Ovarian serous cystadenocarcinoma(28;0.194)			TCAGCCCCACGTGTCCAAGCA	0.458000												
DNAJC5B	85479	broad.mit.edu	37	8	66989024	66989024	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr8:66989024C>T	uc003xvs.1	+	4	540	c.249C>T	c.(247-249)TAC>TAT	p.Y83Y	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	83	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			ACGACAAGTACGGATCGCTGG	0.463000												
TRIM55	84675	broad.mit.edu	37	8	67049353	67049353	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr8:67049353C>T	uc003xvv.2	+	4	757	c.531C>T	c.(529-531)GCC>GCT	p.A177A	TRIM55_uc003xvu.2_Silent_p.A177A|TRIM55_uc003xvw.2_Silent_p.A177A|TRIM55_uc003xvx.2_Silent_p.A177A	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	177	Potential.					cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			ATGGCATCGCCATCCTCGTGG	0.507000												
ZFHX4	79776	broad.mit.edu	37	8	77765033	77765033	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr8:77765033T>G	uc003yav.2	+	10	6128	c.5741T>G	c.(5740-5742)CTT>CGT	p.L1914R	ZFHX4_uc003yau.1_Missense_Mutation_p.L1959R|ZFHX4_uc003yaw.1_Missense_Mutation_p.L1914R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1914	C2H2-type 14.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCCAATGTTCTTATTTTAAAG	0.398000										HNSCC(33;0.089)		
CA13	377677	broad.mit.edu	37	8	86171655	86171655	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr8:86171655C>T	uc003ydg.2	+	3	583	c.241C>T	c.(241-243)CGT>TGT	p.R81C	CA13_uc003ydf.1_RNA	NM_198584	NP_940986	Q8N1Q1	CAH13_HUMAN	carbonic anhydrase XIII	81					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0						TTTAGTTCTGCGTGGTGGTCC	0.458000												
SLC26A7	115111	broad.mit.edu	37	8	92352728	92352728	+	Silent	SNP	T	T	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr8:92352728T>C	uc003yex.2	+	9	1253	c.975T>C	c.(973-975)GCT>GCC	p.A325A	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Silent_p.A325A|SLC26A7_uc003yfa.2_Silent_p.A325A	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	325	Helical; (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			CCTCACTGGCTCTTGCTCAAG	0.502000												
KCNK9	51305	broad.mit.edu	37	8	140630698	140630698	+	Missense_Mutation	SNP	G	G	A	rs145490321		TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr8:140630698G>A	uc003yvf.1	-	2	992	c.928C>T	c.(928-930)CGC>TGC	p.R310C	KCNK9_uc003yvg.1_Missense_Mutation_p.R310C|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	310	Cytoplasmic (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			GCCACCGAGCGGCCGCCATAG	0.622000												
OR13C4	138804	broad.mit.edu	37	9	107289090	107289090	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr9:107289090A>G	uc011lvn.1	-	1	401	c.401T>C	c.(400-402)ATC>ACC	p.I134T		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	134	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GTTCATGATGATGGGGTATCT	0.453000												
OR13D1	286365	broad.mit.edu	37	9	107457263	107457263	+	Silent	SNP	C	C	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr9:107457263C>A	uc011lvs.1	+	1	561	c.561C>A	c.(559-561)ACC>ACA	p.T187T		NM_001004484	NP_001004484	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D,	187	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GCTGTCTGACCTCCCTATTGC	0.438000												
SURF2	6835	broad.mit.edu	37	9	136227269	136227269	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr9:136227269G>A	uc004cdi.2	+	5	694	c.646G>A	c.(646-648)GAG>AAG	p.E216K		NM_017503	NP_059973	Q15527	SURF2_HUMAN	surfeit 2	216							protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		GAGCAGGAGAGAGACGACCGT	0.552000												
SEC16A	9919	broad.mit.edu	37	9	139342536	139342536	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr9:139342536C>T	uc004chx.2	-	24	6699	c.6390G>A	c.(6388-6390)TCG>TCA	p.S2130S	SEC16A_uc004chp.2_5'Flank|SEC16A_uc004chq.2_5'Flank|SEC16A_uc011mea.1_5'Flank|SEC16A_uc004chr.2_Silent_p.S136S|SEC16A_uc004chs.2_5'UTR|SEC16A_uc004cht.2_Silent_p.S161S|SEC16A_uc004chu.2_Silent_p.S315S|SEC16A_uc004chv.3_Silent_p.S1520S|SEC16A_uc004chw.2_Silent_p.S2130S|SEC16A_uc010nbn.2_Silent_p.S2130S	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1952	Required for interaction with SEC23A.|Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CAGCACTCACCGATTTGTTCT	0.388000												
SHROOM2	357	broad.mit.edu	37	X	9905182	9905182	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chrX:9905182G>A	uc004csu.1	+	7	3686	c.3596G>A	c.(3595-3597)CGG>CAG	p.R1199Q	SHROOM2_uc004csv.2_Missense_Mutation_p.R34Q|SHROOM2_uc011mic.1_Missense_Mutation_p.R34Q|SHROOM2_uc004csw.1_Missense_Mutation_p.R34Q	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	1199					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				AGAATTGAGCGGGTGATGGAC	0.582000												
PHKA2	5256	broad.mit.edu	37	X	18926989	18926989	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chrX:18926989C>G	uc004cyv.3	-	21	2720	c.2290G>C	c.(2290-2292)GTT>CTT	p.V764L	PHKA2_uc004cyu.3_Missense_Mutation_p.V62L	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	764					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					AGCTGCTCAACCAGCTTCTCA	0.403000												
CXorf58	254158	broad.mit.edu	37	X	23953497	23953497	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chrX:23953497C>T	uc004daz.1	+	7	1084	c.740C>T	c.(739-741)ACG>ATG	p.T247M	CXorf58_uc011mju.1_Missense_Mutation_p.T247M	NM_152761	NP_689974	Q96LI9	CX058_HUMAN	hypothetical protein LOC254158	247											0						AGACCAGTAACGCAAGAGATC	0.368000												
CCNB3	85417	broad.mit.edu	37	X	50051783	50051783	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chrX:50051783C>T	uc004dox.3	+	6	912	c.614C>T	c.(613-615)GCG>GTG	p.A205V	CCNB3_uc004doy.2_Missense_Mutation_p.A205V|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	205					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					AGTGATGATGCGTTTGTTATA	0.403000												
RAB40A	142684	broad.mit.edu	37	X	102755046	102755046	+	Silent	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chrX:102755046C>T	uc004ekk.2	-	3	981	c.639G>A	c.(637-639)CCG>CCA	p.P213P		NM_080879	NP_543155	Q8WXH6	RB40A_HUMAN	RAB40A, member RAS oncogene family	213	SOCS box.				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0						TACTGGGGAGCGGGAGCTTGT	0.587000												
ZIC3	7547	broad.mit.edu	37	X	136652214	136652214	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chrX:136652214C>A	uc004fak.2	+	3	1894	c.1389C>A	c.(1387-1389)AAC>AAA	p.N463K		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	463					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CTAATTTTAACGAATGGTACG	0.403000												
PLXNB3	5365	broad.mit.edu	37	X	153036318	153036318	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chrX:153036318C>T	uc004fii.2	+	11	2290	c.2116C>T	c.(2116-2118)CGG>TGG	p.R706W	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.1_Missense_Mutation_p.R388W|PLXNB3_uc010nuk.2_Missense_Mutation_p.R729W|PLXNB3_uc011mzd.1_Missense_Mutation_p.R345W	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	706	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CCTACGCGTGCGGAACCTTCA	0.642000												
HIVEP3	59269	broad.mit.edu	37	1	41990510	41990511	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:41990509_41990510T>TC	uc001cgz.4	-	5	6492_6493	c.5279_5280A>GA	c.(5278-5280)ggafs	p.G1760fs	HIVEP3_uc001cha.4_Frame_Shift_Ins_p.G1760fs|HIVEP3_uc001cgy.3_Intron	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	Homo sapiens human immunodeficiency virus type I enhancer binding protein 3 (HIVEP3), transcript variant 1, mRNA.	1760	ZAS2.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGCAGCGAATTCCACACTCCTC	0.495												
MAGI3	260425	broad.mit.edu	37	1	114133188	114133189	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr1:114133187_114133188T>TA	uc001edk.3	+	4	1026_1027	c.845_846T>TA	c.(844-846)tttfs	p.F282fs	MAGI3_uc001edh.3_Frame_Shift_Ins_p.F282fs|MAGI3_uc001edi.4_Frame_Shift_Ins_p.F282fs|MAGI3_uc010owm.2_Frame_Shift_Ins_p.F282fs|MAGI3_uc001edj.3_Frame_Shift_Ins_p.F3fs	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	Homo sapiens membrane associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3), transcript variant 1, mRNA.	282	Guanylate kinase-like.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCCATGGACTTTAGAAATTATA	0.416												
HBP1	26959	broad.mit.edu	37	7	106836508	106836508	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr7:106836507_106836507TA>T	uc003vdy.3	+	8	1482	c.1296_1296TA>T	c.(1294-1296)aatfs	p.N432fs	HBP1_uc011klv.2_Frame_Shift_Del_p.N442fs|HBP1_uc003vdz.3_Frame_Shift_Del_p.N432fs|HBP1_uc003vea.3_Frame_Shift_Del_p.N432fs|HBP1_uc003veb.1_Frame_Shift_Del_p.N432fs	NM_012257	NP_036389	O60381	HBP1_HUMAN	Homo sapiens HMG-box transcription factor 1 (HBP1), transcript variant 2, mRNA.	432					Wnt receptor signaling pathway|cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(4)|lung(3)|prostate(1)|skin(2)	10						CTTCTCCTAATAAGTGCAAAA	0.403												
ZNF160	90338	broad.mit.edu	37	19	53571594	53571595	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CD-5800-01A-11D-1600-08	TCGA-CD-5800-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4438b658-ee94-44a8-9623-8cc28409bd05	9e13e9e2-7455-414a-bf94-70929fe16f6b	g.chr19:53571593_53571594G>GT	uc010eqk.3	-	6	2609_2610	c.2193_2194C>AC	c.(2191-2196)aaacctfs	p.K731fs	ZNF160_uc002qaq.4_Frame_Shift_Ins_p.K731fs|ZNF160_uc002qar.4_Frame_Shift_Ins_p.K731fs	NM_001102603	NP_942596	Q9HCG1	ZN160_HUMAN	Homo sapiens zinc finger protein 160 (ZNF160), transcript variant 3, mRNA.	731					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		CATTTGTAAGGTTTTTTCCCAG	0.450