Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
NEXN	91624	broad.mit.edu	37	1	78395101	78395101	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr1:78395101G>C	uc001dic.3	+	9	1262	c.965G>C	c.(964-966)AGA>ACA	p.R322T	NEXN_uc001dia.3_Missense_Mutation_p.R308T|NEXN_uc009wcb.1_Missense_Mutation_p.R244T|NEXN_uc001dib.3_Missense_Mutation_p.R258T|NEXN_uc001did.1_Missense_Mutation_p.R232T|NEXN_uc001dif.1_Missense_Mutation_p.R214T	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	322	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)		aggcaaagaagagaagatgaa	0.229000												
COL24A1	255631	broad.mit.edu	37	1	86591541	86591541	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr1:86591541C>T	uc001dlj.2	-	3	520	c.478G>A	c.(478-480)GAT>AAT	p.D160N	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.D160N	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	160	TSP N-terminal.|Laminin G-like.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CATTGCTCATCATGAACACTG	0.343000												
BPNT1	10380	broad.mit.edu	37	1	220242771	220242771	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr1:220242771C>T	uc001hma.2	-	5	509	c.337G>A	c.(337-339)GTG>ATG	p.V113M	BPNT1_uc010pug.1_Missense_Mutation_p.V58M|BPNT1_uc010puh.1_Missense_Mutation_p.V77M|BPNT1_uc001hmb.3_Missense_Mutation_p.V113M	NM_006085	NP_006076	O95861	BPNT1_HUMAN	3'(2'), 5'-bisphosphate nucleotidase 1	113					3'-phosphoadenosine 5'-phosphosulfate metabolic process|nervous system development|xenobiotic metabolic process	cytosol	3'(2'),5'-bisphosphate nucleotidase activity			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0558)		ACCCAGACCACGAGCTAAAAT	0.313000												
USP54	159195	broad.mit.edu	37	10	75258563	75258563	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr10:75258563G>A	uc001juo.2	-	22	4896	c.4879C>T	c.(4879-4881)CGA>TGA	p.R1627*	PPP3CB_uc001juf.2_5'Flank|PPP3CB_uc001jue.2_5'Flank|PPP3CB_uc001jug.2_5'Flank|PPP3CB_uc001jui.2_5'Flank|PPP3CB_uc001juh.2_5'Flank|USP54_uc010qkk.1_Nonsense_Mutation_p.R762*|USP54_uc001juk.2_Nonsense_Mutation_p.R715*|USP54_uc001jul.2_Nonsense_Mutation_p.R668*|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	1627					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					CCAGGGGTTCGGGACCCTGGA	0.552000												
PRR5L	79899	broad.mit.edu	37	11	36484155	36484155	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr11:36484155C>A	uc001mwo.3	+	9	1365	c.976C>A	c.(976-978)CCA>ACA	p.P326T	PRR5L_uc001mwp.2_Missense_Mutation_p.P326T|PRR5L_uc009ykk.2_Missense_Mutation_p.P198T|PRR5L_uc010rfc.1_3'UTR	NM_001160167	NP_001153639	Q6MZQ0	PRR5L_HUMAN	protor-2 isoform a	326										ovary(1)	1						CCTGCTCCTGCCACCCAGCTT	0.677000												
ARFGAP2	84364	broad.mit.edu	37	11	47196833	47196833	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr11:47196833G>C	uc001ndt.2	-	4	311	c.296C>G	c.(295-297)GCC>GGC	p.A99G	ARFGAP2_uc010rha.1_5'Flank|ARFGAP2_uc010rhb.1_Missense_Mutation_p.A99G|ARFGAP2_uc001ndu.2_Intron|ARFGAP2_uc010rhc.1_Intron|ARFGAP2_uc010rhd.1_Missense_Mutation_p.A99G|ARFGAP2_uc001ndv.1_3'UTR	NM_032389	NP_115765	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating	99	Required for interaction with coatomer.|Arf-GAP.				protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			ovary(1)	1						GGCATCATTGGCTGTGCATCC	0.547000												
MS4A14	84689	broad.mit.edu	37	11	60183690	60183690	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr11:60183690C>T	uc001npj.2	+	5	1814	c.1249C>T	c.(1249-1251)CCT>TCT	p.P417S	MS4A14_uc001npi.2_Missense_Mutation_p.P305S|MS4A14_uc001npn.2_Missense_Mutation_p.P155S|MS4A14_uc001npk.2_Missense_Mutation_p.P400S|MS4A14_uc001npl.2_Missense_Mutation_p.P155S|MS4A14_uc001npm.2_Missense_Mutation_p.P155S	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	417						integral to membrane	receptor activity			breast(1)	1						tgccatATTACCTGAAGCCTC	0.234000												
FIBP	9158	broad.mit.edu	37	11	65655421	65655421	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr11:65655421C>T	uc001ogd.2	-	2	389	c.268G>A	c.(268-270)GCA>ACA	p.A90T	FIBP_uc009yqu.2_Missense_Mutation_p.A87T|FIBP_uc001oge.2_Missense_Mutation_p.A90T|FIBP_uc010roq.1_Missense_Mutation_p.A90T|FIBP_uc010ror.1_Missense_Mutation_p.A90T|CCDC85B_uc001ogf.2_5'Flank	NM_198897	NP_942600	O43427	FIBP_HUMAN	FGF intracellular binding protein isoform a	90					fibroblast growth factor receptor signaling pathway	endomembrane system|membrane|microsome|mitochondrion|nucleus	fibroblast growth factor binding			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.166)		ATGAGTAGTGCCTGCCGGGAG	0.433000												
WNK1	65125	broad.mit.edu	37	12	1005298	1005298	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr12:1005298C>T	uc001qio.3	+	24	6152	c.5645C>T	c.(5644-5646)TCT>TTT	p.S1882F	WNK1_uc001qip.3_Missense_Mutation_p.S1634F|WNK1_uc001qir.3_Missense_Mutation_p.S1055F	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1882					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GATGCAAAGTCTGTTCATTTT	0.423000												
GALNT8	26290	broad.mit.edu	37	12	4853826	4853826	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr12:4853826G>A	uc001qne.1	+	4	912	c.820G>A	c.(820-822)GTC>ATC	p.V274I		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	274	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						AGCAGACGTGGTCGCCATCTT	0.498000												
GSG1	83445	broad.mit.edu	37	12	13241798	13241798	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr12:13241798C>T	uc001rbn.2	-	4	652	c.479G>A	c.(478-480)AGA>AAA	p.R160K	GSG1_uc001rbj.2_Missense_Mutation_p.R124K|GSG1_uc001rbk.2_Missense_Mutation_p.R124K|GSG1_uc001rbl.2_Missense_Mutation_p.R147K|GSG1_uc001rbm.2_Missense_Mutation_p.R124K|GSG1_uc001rbo.2_Missense_Mutation_p.R160K|GSG1_uc001rbp.2_Missense_Mutation_p.R137K|GSG1_uc001rbq.1_Missense_Mutation_p.R160K	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	147						endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		TTTCTCACCTCTCTTGGCTGG	0.527000												
DGKA	1606	broad.mit.edu	37	12	56334503	56334503	+	Silent	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr12:56334503C>T	uc001sij.2	+	12	1278	c.1014C>T	c.(1012-1014)GTC>GTT	p.V338V	DGKA_uc009zoc.1_Silent_p.V338V|DGKA_uc001sih.1_Silent_p.V226V|DGKA_uc001sii.1_Silent_p.V196V|DGKA_uc009zod.1_Silent_p.V257V|DGKA_uc001sik.2_Silent_p.V338V|DGKA_uc001sil.2_Silent_p.V338V|DGKA_uc001sim.2_Silent_p.V338V|DGKA_uc001sin.2_Silent_p.V338V|DGKA_uc009zof.2_5'UTR|DGKA_uc001sio.2_Silent_p.V80V	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	338					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	ATCCCAGTGTCCTGGTGAGAC	0.572000											OREG0021913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
DGKA	1606	broad.mit.edu	37	12	56335359	56335359	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr12:56335359C>T	uc001sij.2	+	15	1505	c.1241C>T	c.(1240-1242)CCT>CTT	p.P414L	DGKA_uc001sih.1_Missense_Mutation_p.P302L|DGKA_uc001sii.1_Missense_Mutation_p.P272L|DGKA_uc009zod.1_Missense_Mutation_p.P333L|DGKA_uc001sik.2_Missense_Mutation_p.P414L|DGKA_uc001sil.2_Missense_Mutation_p.P414L|DGKA_uc001sim.2_Missense_Mutation_p.P414L|DGKA_uc001sin.2_Missense_Mutation_p.P414L|DGKA_uc009zof.2_Missense_Mutation_p.P60L|DGKA_uc001sio.2_Missense_Mutation_p.P156L	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	414	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	AAGGATGGTCCTGAGATAGGG	0.473000												
SUOX	6821	broad.mit.edu	37	12	56397752	56397752	+	Silent	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr12:56397752C>T	uc001six.2	+	6	905	c.579C>T	c.(577-579)CCC>CCT	p.P193P	SUOX_uc001siy.2_Silent_p.P193P|SUOX_uc001siz.2_Silent_p.P193P|SUOX_uc001sja.2_Silent_p.P193P	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	193	Molybdenum-pterin domain (By similarity).					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			GCCAGCGGCCCTTTAATGCAG	0.547000												
MLXIP	22877	broad.mit.edu	37	12	122615390	122615390	+	Splice_Site	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr12:122615390G>A	uc001ubq.2	+	7	911	c.911_splice	c.e7-1	p.A304_splice	MLXIP_uc001ubr.2_Splice_Site_p.A55_splice|MLXIP_uc001ubs.1_5'Flank|MLXIP_uc001ubt.2_5'Flank	NM_014938	NP_055753	Q9HAP2	MLXIP_HUMAN	MLX interacting protein						regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			ovary(2)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		GATTCTTGCAGCACATCTGGG	0.502000											OREG0022218	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
MYCBP2	23077	broad.mit.edu	37	13	77671839	77671839	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr13:77671839C>T	uc001vkf.2	-	57	9427	c.9336G>A	c.(9334-9336)ATG>ATA	p.M3112I	MYCBP2_uc010aev.2_Missense_Mutation_p.M2516I|MYCBP2_uc001vkg.1_Missense_Mutation_p.M635I|MYCBP2_uc010aew.2_Missense_Mutation_p.M498I	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ACTTAGACTTCATTGTGTTAT	0.388000												
FANCM	57697	broad.mit.edu	37	14	45657009	45657009	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr14:45657009G>A	uc001wwd.3	+	19	4797	c.4698G>A	c.(4696-4698)ATG>ATA	p.M1566I	FANCM_uc010anf.2_Missense_Mutation_p.M1540I|FANCM_uc001wwe.3_Missense_Mutation_p.M1102I|FANCM_uc010ang.2_Missense_Mutation_p.M780I	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1566					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						CTATTTACATGAAATCTTTGC	0.259000								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia			
ZFYVE26	23503	broad.mit.edu	37	14	68250043	68250043	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr14:68250043G>A	uc001xka.2	-	21	3965	c.3826C>T	c.(3826-3828)CCG>TCG	p.P1276S	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.P1276S	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1276					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GTTGTCCTCGGGGAGCTCGGT	0.577000												
MAPKBP1	23005	broad.mit.edu	37	15	42115796	42115796	+	Silent	SNP	C	C	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr15:42115796C>A	uc001zok.3	+	30	4054	c.3768C>A	c.(3766-3768)GCC>GCA	p.A1256A	MAPKBP1_uc001zoj.3_Silent_p.A1250A|MAPKBP1_uc010bcj.2_Silent_p.A757A|MAPKBP1_uc010bci.2_Intron|MAPKBP1_uc010udb.1_Silent_p.A1089A|MAPKBP1_uc010bck.2_Silent_p.A467A|MAPKBP1_uc010bcl.2_Silent_p.A757A	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	1256										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		GTTCCATGGCCAAGATATCCC	0.617000												
C17orf85	55421	broad.mit.edu	37	17	3716433	3716434	+	Nonsense_Mutation	DNP	GC	GC	AT			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr17:3716433_3716434GC>AT	uc010ckl.1	-	13	1790_1791	c.1767_1768GC>AT	c.(1765-1770)GAGCAG>GAATAG	p.Q590*	C17orf85_uc002fwr.2_Nonsense_Mutation_p.Q300*|C17orf85_uc002fwq.2_Nonsense_Mutation_p.Q310*	NM_001114118	NP_001107590	Q53F19	CQ085_HUMAN	ELG protein isoform a	590							nucleotide binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		TGGCGAGACTGCTCTTTCTCCT	0.515000												
RHBDL3	162494	broad.mit.edu	37	17	30615917	30615917	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr17:30615917G>A	uc002hhe.1	+	4	415	c.401G>A	c.(400-402)CGA>CAA	p.R134Q	RHBDL3_uc010csw.1_Missense_Mutation_p.R126Q|RHBDL3_uc010csx.1_Missense_Mutation_p.R134Q|RHBDL3_uc010csy.1_Missense_Mutation_p.R36Q|RHBDL3_uc002hhf.1_Missense_Mutation_p.R36Q	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	134					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)				CTCTCGCAGCGACTTATCCGC	0.602000												
EFTUD2	9343	broad.mit.edu	37	17	42940215	42940215	+	Silent	SNP	G	G	A	rs149288120		TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr17:42940215G>A	uc002ihn.2	-	16	1734	c.1473C>T	c.(1471-1473)CAC>CAT	p.H491H	EFTUD2_uc010wje.1_Silent_p.H456H|EFTUD2_uc010wjf.1_Silent_p.H481H	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	491						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				GGCCAAAGGCGTGAAACTGGA	0.557000												
PPP4R1	9989	broad.mit.edu	37	18	9595144	9595144	+	Silent	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr18:9595144C>T	uc002koe.1	-	3	178	c.60G>A	c.(58-60)GTG>GTA	p.V20V	PPP4R1_uc010wzo.1_5'UTR|PPP4R1_uc002kod.1_Intron|PPP4R1_uc010wzp.1_Intron	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	20	HEAT 1.				protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1						TGTAGTCATCCACACCAACTA	0.423000												
SUPT5H	6829	broad.mit.edu	37	19	39960816	39960816	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr19:39960816G>A	uc002olo.3	+	17	1611	c.1432G>A	c.(1432-1434)GTG>ATG	p.V478M	SUPT5H_uc002olp.3_Missense_Mutation_p.V478M|SUPT5H_uc002olq.3_Missense_Mutation_p.V474M|SUPT5H_uc002oln.3_Missense_Mutation_p.V478M|SUPT5H_uc002olr.3_Missense_Mutation_p.V478M|SUPT5H_uc002ols.1_Missense_Mutation_p.V101M|SUPT5H_uc010egp.1_5'Flank	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	478	KOW 3.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGGGGACCACGTGAAGGTGAT	0.537000												
CKM	1158	broad.mit.edu	37	19	45815134	45815134	+	Silent	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr19:45815134G>A	uc002pbd.2	-	5	600	c.526C>T	c.(526-528)CTG>TTG	p.L176L		NM_001824	NP_001815	P06732	KCRM_HUMAN	muscle creatine kinase	176	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity			skin(1)	1		Ovarian(192;0.0336)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;2.29e-44)|Epithelial(262;1.05e-38)|GBM - Glioblastoma multiforme(486;3.56e-07)	Creatine(DB00148)	ATGCTCTTCAGAGGGTAGTAC	0.607000												
KCNF1	3754	broad.mit.edu	37	2	11053370	11053370	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr2:11053370C>T	uc002rax.2	+	1	1308	c.818C>T	c.(817-819)ACG>ATG	p.T273M		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	273						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		CTCACGCTCACGCACCTGGGT	0.632000												
GDF7	151449	broad.mit.edu	37	2	20871059	20871059	+	Silent	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr2:20871059G>A	uc002rdz.1	+	2	1803	c.1227G>A	c.(1225-1227)GCG>GCA	p.A409A		NM_182828	NP_878248	Q7Z4P5	GDF7_HUMAN	growth differentiation factor 7 preproprotein	409					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACCAGACGCGGCGCCGGCCT	0.612000												
TCF23	150921	broad.mit.edu	37	2	27373194	27373194	+	Silent	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr2:27373194G>A	uc010ylg.1	+	2	426	c.426G>A	c.(424-426)CCG>CCA	p.P142P		NM_175769	NP_786951	Q7RTU1	TCF23_HUMAN	transcription factor 23	142					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGCCTGGCCGCCCTTCCTGC	0.622000												
GPR39	2863	broad.mit.edu	37	2	133175294	133175294	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr2:133175294G>A	uc002ttl.2	+	1	1148	c.679G>A	c.(679-681)GCC>ACC	p.A227T		NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	227	Helical; Name=5; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						CATCTTCGGCGCCTTCGTGGT	0.612000												
TNS1	7145	broad.mit.edu	37	2	218683433	218683433	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr2:218683433G>A	uc002vgt.2	-	24	3708	c.3310C>T	c.(3310-3312)CGG>TGG	p.R1104W	TNS1_uc002vgr.2_Missense_Mutation_p.R1091W|TNS1_uc002vgs.2_Missense_Mutation_p.R1083W|TNS1_uc010zjv.1_Missense_Mutation_p.R1083W	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	1104	Ser-rich.					cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GTGGGCGTCCGGGGACCCTGG	0.612000												
EMILIN3	90187	broad.mit.edu	37	20	39991532	39991532	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr20:39991532A>G	uc002xjy.1	-	4	901	c.677T>C	c.(676-678)TTT>TCT	p.F226S		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	226						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				GATGACCCCAAAGCCCACAGG	0.607000												
KCNH8	131096	broad.mit.edu	37	3	19384207	19384207	+	Splice_Site	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr3:19384207G>A	uc003cbk.1	+	4	765	c.570_splice	c.e4+1	p.N190_splice	KCNH8_uc011awe.1_Splice_Site_p.N190_splice|KCNH8_uc010hex.1_Splice_Site	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,							integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						AATAAATAACGTAGGTGGTAT	0.453000												
C3orf72	401089	broad.mit.edu	37	3	138669287	138669287	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr3:138669287G>C	uc003esx.1	+	3	532	c.401G>C	c.(400-402)GGA>GCA	p.G134A	C3orf72_uc011bmr.1_3'UTR	NM_001040061	NP_001035150	Q6ZUU3	CC072_HUMAN	chromosome 3 open reading frame 72	134											0						TTCCTAGCGGGACCCCGAAAC	0.667000												
GHSR	2693	broad.mit.edu	37	3	172165669	172165669	+	Missense_Mutation	SNP	A	A	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr3:172165669A>T	uc003fib.1	-	1	535	c.535T>A	c.(535-537)TTC>ATC	p.F179I	GHSR_uc011bpv.1_Missense_Mutation_p.F179I	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	179	Helical; Name=4; (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			ACTAGCACGAAGATGGGCCCG	0.662000												
TBCCD1	55171	broad.mit.edu	37	3	186272346	186272346	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr3:186272346A>G	uc003fqg.2	-	6	1370	c.1241T>C	c.(1240-1242)GTA>GCA	p.V414A	TBCCD1_uc011bry.1_Missense_Mutation_p.V414A|TBCCD1_uc003fqh.2_Missense_Mutation_p.V318A	NM_018138	NP_060608	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	414	C-CAP/cofactor C-like.				cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			large_intestine(1)|ovary(1)	2	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		GGCAAAAGTTACTGTCTGGTT	0.458000												
RFC4	5984	broad.mit.edu	37	3	186509621	186509621	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr3:186509621T>C	uc003fqz.2	-	8	917	c.694A>G	c.(694-696)AAA>GAA	p.K232E	RFC4_uc011bsc.1_Missense_Mutation_p.K232E|RFC4_uc011bsd.1_Missense_Mutation_p.K232E	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	232					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		TCTGACACTTTAACAAGATAA	0.323000												
C4orf50	389197	broad.mit.edu	37	4	5969171	5969171	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr4:5969171C>T	uc003git.1	-	5	517	c.427G>A	c.(427-429)GTC>ATC	p.V143I		NM_207405	NP_997288	Q6ZRC1	CD050_HUMAN	hypothetical protein LOC389197	143										pancreas(2)|breast(1)	3						TCAGACTTGACGTCCAGGTGG	0.512000												
ASB5	140458	broad.mit.edu	37	4	177142387	177142387	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr4:177142387C>A	uc003iuq.1	-	5	605	c.589G>T	c.(589-591)GAA>TAA	p.E197*	ASB5_uc003iup.1_Nonsense_Mutation_p.E144*	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	197					intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		TGAGGAATTTCTTGGTCAACA	0.418000												
KIAA0947	23379	broad.mit.edu	37	5	5463022	5463022	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr5:5463022C>T	uc003jdm.3	+	13	3797	c.3575C>T	c.(3574-3576)TCT>TTT	p.S1192F		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1192										ovary(1)|central_nervous_system(1)	2						TCAGGGGACTCTGTTTCTGAA	0.373000												
ENC1	8507	broad.mit.edu	37	5	73931260	73931260	+	Missense_Mutation	SNP	C	C	G	rs144525141		TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr5:73931260C>G	uc003kdc.3	-	2	2182	c.1051G>C	c.(1051-1053)GAA>CAA	p.E351Q	ENC1_uc011css.1_Missense_Mutation_p.E278Q	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	351	Kelch 2.				nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		ACCCCATTTTCAGACCCCCGC	0.532000												
F12	2161	broad.mit.edu	37	5	176832124	176832124	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr5:176832124C>T	uc003mgo.3	-	6	509	c.460G>A	c.(460-462)GAG>AAG	p.E154K	F12_uc011dfy.1_5'Flank|F12_uc003mgn.3_5'Flank|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	154	Fibronectin type-I.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTGCTTGCTCAGTTCTATAC	0.562000									Hereditary_Angioedema			
HIST1H1E	3008	broad.mit.edu	37	6	26156976	26156976	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr6:26156976G>A	uc003ngq.2	+	1	418	c.358G>A	c.(358-360)GCT>ACT	p.A120T	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	120					nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						CAAGCCTAAGGCTAAAAAGGC	0.642000												
ZNF187	7741	broad.mit.edu	37	6	28240525	28240525	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr6:28240525C>T	uc011dld.1	+	4	766	c.496C>T	c.(496-498)CGG>TGG	p.R166W	ZNF187_uc011dlc.1_Missense_Mutation_p.R167W|ZNF187_uc003nku.3_Missense_Mutation_p.R32W|ZNF187_uc003nkw.3_Missense_Mutation_p.R13W|ZNF187_uc011dle.1_Missense_Mutation_p.R13W|ZNF187_uc011dlf.1_Intron|ZNF187_uc011dlg.1_Missense_Mutation_p.R13W	NM_001111039	NP_001104509	Q16670	ZN187_HUMAN	zinc finger protein 187 isoform b	166					viral reproduction	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACAGCAGGTTCGGCATGAGTG	0.478000												
ZFP57	346171	broad.mit.edu	37	6	29643828	29643828	+	Silent	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr6:29643828G>A	uc011dlw.1	-	2	283	c.132C>T	c.(130-132)GTC>GTT	p.V44V	ZFP57_uc003nnl.3_Silent_p.V24V	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	16	KRAB.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						CCTCAAAGGTGACTGGCTTCT	0.378000												
RING1	6015	broad.mit.edu	37	6	33177736	33177736	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr6:33177736G>A	uc003odk.2	+	4	478	c.284G>A	c.(283-285)CGA>CAA	p.R95Q	RING1_uc011dqx.1_Missense_Mutation_p.R95Q|RING1_uc003odl.2_Missense_Mutation_p.R66Q	NM_002931	NP_002922	Q06587	RING1_HUMAN	ring finger protein 1	95	Necessary for transcriptional repression (By similarity).				histone H2A monoubiquitination|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear speck|PcG protein complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						GTGTCCAAGCGATCCCTACGG	0.562000												
SMOC2	64094	broad.mit.edu	37	6	168910683	168910683	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr6:168910683G>T	uc003qws.1	+	2	193	c.173G>T	c.(172-174)AGG>ATG	p.R58M	SMOC2_uc003qwr.1_Missense_Mutation_p.R58M	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	58	Kazal-like.				signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		TCTGACGGAAGGACCTTCCTT	0.468000												
RNF216	54476	broad.mit.edu	37	7	5781105	5781105	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr7:5781105C>A	uc003soy.1	-	4	562	c.372G>T	c.(370-372)TTG>TTT	p.L124F	RNF216_uc010ksz.1_5'UTR|RNF216_uc010kta.1_Intron|RNF216_uc011jwj.1_Intron|RNF216_uc003sox.1_Missense_Mutation_p.L181F	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	124					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TACCTTCTTCCAAGATGATGA	0.458000												
CREB5	9586	broad.mit.edu	37	7	28844124	28844124	+	Silent	SNP	C	C	T			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr7:28844124C>T	uc003szq.2	+	8	1401	c.1011C>T	c.(1009-1011)ACC>ACT	p.T337T	CREB5_uc003szo.2_Silent_p.T304T|CREB5_uc003szr.2_Silent_p.T330T|CREB5_uc003szs.2_Silent_p.T198T	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	337					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						CCCTGCACACCGGCAACCAAG	0.363000												
ESCO2	157570	broad.mit.edu	37	8	27660907	27660907	+	Silent	SNP	C	C	G			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr8:27660907C>G	uc003xgg.2	+	11	1841	c.1758C>G	c.(1756-1758)ACC>ACG	p.T586T	ESCO2_uc010luy.1_Intron	NM_001017420	NP_001017420	Q56NI9	ESCO2_HUMAN	establishment of cohesion 1 homolog 2	586					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			central_nervous_system(1)	1		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		TATTTGCAACCAAGTACTGCA	0.358000									SC_Phocomelia_syndrome			
SULF1	23213	broad.mit.edu	37	8	70536309	70536309	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr8:70536309G>A	uc010lza.1	+	15	2444	c.1727G>A	c.(1726-1728)CGT>CAT	p.R576H	SULF1_uc003xyd.2_Missense_Mutation_p.R576H|SULF1_uc003xye.2_Missense_Mutation_p.R576H|SULF1_uc003xyf.2_Missense_Mutation_p.R576H|SULF1_uc003xyg.2_Missense_Mutation_p.R576H|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	576					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			ATTGCTAAGCGTCATGATGAA	0.498000												
FREM1	158326	broad.mit.edu	37	9	14748594	14748594	+	Silent	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr9:14748594G>A	uc003zlm.2	-	31	6191	c.5601C>T	c.(5599-5601)AGC>AGT	p.S1867S	FREM1_uc010mic.2_RNA|FREM1_uc003zlk.2_Intron|FREM1_uc003zll.2_Silent_p.S403S	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1867					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TCTCCCATGTGCTGTGCTTGC	0.493000												
C9orf131	138724	broad.mit.edu	37	9	35045805	35045805	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr9:35045805A>G	uc003zvw.2	+	2	3208	c.3179A>G	c.(3178-3180)CAA>CGA	p.Q1060R	C9orf131_uc003zvu.2_Missense_Mutation_p.Q1012R|C9orf131_uc003zvv.2_Missense_Mutation_p.Q987R|C9orf131_uc003zvx.2_Missense_Mutation_p.Q1025R	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	1060											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			AGGGGTTTGCAAAAGGTGTTA	0.512000												
DAPK1	1612	broad.mit.edu	37	9	90321137	90321137	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr9:90321137G>A	uc004apc.2	+	26	3289	c.3151G>A	c.(3151-3153)GTG>ATG	p.V1051M	DAPK1_uc004apd.2_Missense_Mutation_p.V1051M|DAPK1_uc011ltg.1_Missense_Mutation_p.V985M|DAPK1_uc011lth.1_Missense_Mutation_p.V788M|DAPK1_uc004apg.2_Missense_Mutation_p.V28M	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	1051					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						GTTGCTGTCCGTGGAGACCCC	0.642000									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of			
ANKS6	203286	broad.mit.edu	37	9	101536246	101536246	+	Silent	SNP	A	A	G			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr9:101536246A>G	uc004ayu.2	-	9	1755	c.1734T>C	c.(1732-1734)CGT>CGC	p.R578R	ANKS6_uc004ayt.2_Silent_p.R277R|ANKS6_uc004ayv.1_Silent_p.R40R|ANKS6_uc004ayw.1_Silent_p.R160R|ANKS6_uc004ayx.1_RNA|ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	578										ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				TCCCGTTGTGACGCGTCCGGG	0.627000												
IDH3G	3421	broad.mit.edu	37	X	153052343	153052343	+	Silent	SNP	G	G	A	rs141309746		TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chrX:153052343G>A	uc004fip.2	-	10	1023	c.837C>T	c.(835-837)ATC>ATT	p.I279I	IDH3G_uc004fio.2_Silent_p.I221I|IDH3G_uc004fiq.2_Silent_p.I279I|IDH3G_uc010num.2_Silent_p.I221I|IDH3G_uc004fir.2_Silent_p.I221I|IDH3G_uc004fit.1_Silent_p.I279I|IDH3G_uc004fis.2_Silent_p.I221I|IDH3G_uc004fiu.2_Silent_p.I55I	NM_004135	NP_004126	P51553	IDH3G_HUMAN	isocitrate dehydrogenase 3 (NAD+) gamma isoform	279					carbohydrate metabolic process|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleolus	ATP binding|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	CATTGTTGACGATGTTGCCAT	0.607000												
LRRC8B	23507	broad.mit.edu	37	1	90058582	90058582	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr1:90058581_90058581GA>G	uc001dni.3	+	7	2898	c.2391_2391GA>G	c.(2389-2391)cagfs	p.Q797fs	LRRC8B_uc001dnh.3_Frame_Shift_Del_p.Q797fs|LRRC8B_uc001dnj.3_Frame_Shift_Del_p.Q797fs	NM_001134476	NP_056165	Q6P9F7	LRC8B_HUMAN	Homo sapiens leucine rich repeat containing 8 family, member B (LRRC8B), transcript variant 2, mRNA.	797						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		AACGTTTACAGACGTGCTTAG	0.433												
ZC3H15	55854	broad.mit.edu	37	2	187368933	187368934	+	Frame_Shift_Ins	INS	-	-	GA			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr2:187368932_187368933T>TGA	uc002upo.3	+	5	933_934	c.708_709T>TGA	c.(706-711)attgagfs	p.I236fs		NM_018471	NP_060941	Q8WU90	ZC3HF_HUMAN	Homo sapiens zinc finger CCCH-type containing 15 (ZC3H15), mRNA.	236	Required for interaction with DRG1 (By similarity).					cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding	p.L235L(1)		breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|skin(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)			AAGATCTAATTGAGAGAGAGGT	0.327												
TBCCD1	55171	broad.mit.edu	37	3	186272188	186272190	+	In_Frame_Del	DEL	AGA	AGA	-	rs144228045		TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr3:186272187_186272189TAGA>T	uc003fqg.3	-	5	1527_1529	c.1398_1400TCTA>A	c.(1396-1401)ttctat>ttAt	p.466_467FY>L	TBCCD1_uc011bry.2_In_Frame_Del_p.466_467FY>L|TBCCD1_uc003fqh.3_In_Frame_Del_p.370_371FY>L	NM_018138	NP_060608	Q9NVR7	TBCC1_HUMAN	Homo sapiens TBCC domain containing 1 (TBCCD1), transcript variant 2, mRNA.	466					cell morphogenesis|maintenance of Golgi location|maintenance of centrosome location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding	p.F466L(2)		breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|skin(1)	17	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		AATAAATACATAGAATTCACAAG	0.443												
TJP1	7082	broad.mit.edu	37	15	30065540	30065545	+	In_Frame_Del	DEL	TCCAAA	TCCAAA	-			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr15:30065539_30065544TTCCAAA>T	uc001zcr.3	-	2	576_581	c.101_106TTTGGAA>A	c.(100-108)tttggaatt>tAtt	p.34_36FGI>Y	TJP1_uc010azl.3_In_Frame_Del_p.22_24FGI>Y|TJP1_uc001zcq.3_In_Frame_Del_p.38_40FGI>Y|TJP1_uc001zcs.3_In_Frame_Del_p.34_36FGI>Y	NM_003257	NP_003248	Q07157	ZO1_HUMAN	Homo sapiens tight junction protein 1 (zona occludens 1) (TJP1), transcript variant 1, mRNA.	34	PDZ 1.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	Golgi apparatus|basolateral plasma membrane|cell-cell adherens junction|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GATATTGCAATTCCAAATCCAAATCC	0.364												
ABCA9	10350	broad.mit.edu	37	17	67004307	67004317	+	Frame_Shift_Del	DEL	CCAGTGCTTGG	CCAGTGCTTGG	-	rs143208550	byFrequency	TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr17:67004306_67004316ACCAGTGCTTGG>A	uc002jhu.3	-	23	3351_3361	c.3208_3218CCAAGCACTGGT>T	c.(3208-3219)caagcactggtgfs	p.Q1070fs	ABCA9_uc010dez.3_Frame_Shift_Del_p.Q1070fs	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 9 (ABCA9), mRNA.	1070					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					GGAAACATCCACCAGTGCTTGGCCAAACCAG	0.370												
LTBP4	8425	broad.mit.edu	37	19	41122902	41122902	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr19:41122901_41122901GC>G	uc002ooh.1	+	22	3120	c.3120_3120GC>G	c.(3118-3120)cagfs	p.Q1040fs	LTBP4_uc002oog.1_Frame_Shift_Del_p.Q1003fs|LTBP4_uc002ooi.1_Frame_Shift_Del_p.Q973fs|LTBP4_uc002ooj.1_5'UTR|LTBP4_uc002ook.1_Intron|LTBP4_uc002ool.1_Intron|LTBP4_uc002oom.1_Intron|LTBP4_uc010xvp.1_Intron	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	Homo sapiens latent transforming growth factor beta binding protein 4 (LTBP4), transcript variant 1, mRNA.	1040	Cys-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGGCTATCAGCCCACGCCAG	0.592												
SREBF2	6721	broad.mit.edu	37	22	42262865	42262866	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-CD-5802-01A-11D-1600-08	TCGA-CD-5802-10A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c1b44966-0f72-4c4f-8783-ab3ffe7f17b2	af722e36-4912-45c4-b431-a2ceff596bac	g.chr22:42262864_42262865GGA>G	uc003bbi.3	+	1	287_288	c.118_119GGA>G	c.(118-120)ggafs	p.G40fs	bK250D10.C22.8_uc003bba.1_Intron	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	Homo sapiens sterol regulatory element binding transcription factor 2 (SREBF2), mRNA.	40	Transcriptional activation (acidic).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|SREBP-SCAP-Insig complex|nucleus	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						TAATCAAGTGGGAGAGTTCCCT	0.450