Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
ISG15	9636	broad.mit.edu	37	1	949723	949723	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:949723G>A	uc001acj.3	+	2	470	c.363G>A	c.(361-363)CTG>CTA	p.L121L		NM_005101	NP_005092	P05161	ISG15_HUMAN	ISG15 ubiquitin-like modifier precursor	121	Ubiquitin-like 2.				cell-cell signaling|interspecies interaction between organisms|ISG15-protein conjugation|negative regulation of type I interferon production|response to virus|type I interferon-mediated signaling pathway	cytosol|extracellular space	protein binding				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.05e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.54e-23)|Colorectal(212;5.37e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00238)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		AGGACGACCTGTTCTGGCTGA	0.647000												
HTR6	3362	broad.mit.edu	37	1	20005790	20005790	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:20005790G>A	uc001bcl.2	+	3	1719	c.1252G>A	c.(1252-1254)GTC>ATC	p.V418I		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	418	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	CGCTGCCGCCGTCAATTTCTT	0.716000												
EPHB2	2048	broad.mit.edu	37	1	23208893	23208893	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:23208893G>A	uc009vqj.1	+	6	1490	c.1345G>A	c.(1345-1347)GTG>ATG	p.V449M	EPHB2_uc001bge.2_Missense_Mutation_p.V449M|EPHB2_uc001bgf.2_Missense_Mutation_p.V449M|EPHB2_uc010odu.1_Missense_Mutation_p.V449M	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	449	Fibronectin type-III 2.|Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GAGCCGCACCGTGGACAGCAT	0.587000									Hereditary_Prostate_Cancer			
AHDC1	27245	broad.mit.edu	37	1	27876608	27876608	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:27876608G>A	uc009vsy.2	-	6	2988	c.2019C>T	c.(2017-2019)GGC>GGT	p.G673G	AHDC1_uc009vsz.1_Silent_p.G673G	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	673	Gly-rich.						DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		CACCAAAACCGCCTGCTTTGC	0.652000												
CSMD2	114784	broad.mit.edu	37	1	34052210	34052210	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:34052210G>A	uc001bxn.1	-	47	6980	c.6951C>T	c.(6949-6951)ATC>ATT	p.I2317I	CSMD2_uc001bxm.1_Silent_p.I2315I	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2317	Sushi 13.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGTAGCGTACGATGTCACCTG	0.483000												
NEGR1	257194	broad.mit.edu	37	1	72163820	72163820	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:72163820T>C	uc001dfw.2	-	4	638	c.538A>G	c.(538-540)AAA>GAA	p.K180E	NEGR1_uc001dfv.2_Missense_Mutation_p.K52E|NEGR1_uc010oqs.1_Intron	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	180	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		TCAAATGGTTTTGCTATAAAA	0.373000												
C1orf173	127254	broad.mit.edu	37	1	75072397	75072397	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:75072397T>G	uc001dgg.2	-	10	1596	c.1377A>C	c.(1375-1377)CAA>CAC	p.Q459H	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.Q253H	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	459	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TTTTTATTTCTTGAGCTGAAA	0.408000												
COL24A1	255631	broad.mit.edu	37	1	86590871	86590871	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:86590871C>G	uc001dlj.2	-	3	1190	c.1148G>C	c.(1147-1149)AGA>ACA	p.R383T	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.R383T	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	383					cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		ACCAGTTACTCTATCATCATG	0.363000												
HRNR	388697	broad.mit.edu	37	1	152193481	152193481	+	Silent	SNP	G	G	A	rs144030283	byFrequency	TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:152193481G>A	uc001ezt.1	-	3	700	c.624C>T	c.(622-624)CAC>CAT	p.H208H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	208	2.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCCAGAGCCGTGTTGGCCAT	0.567000												
CD1A	909	broad.mit.edu	37	1	158225038	158225038	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:158225038T>G	uc001frt.2	+	2	756	c.223T>G	c.(223-225)TTC>GTC	p.F75V		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	75	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	CAGGGGAAACTTCAGCAATGA	0.478000												
OR10K1	391109	broad.mit.edu	37	1	158435857	158435857	+	Missense_Mutation	SNP	A	A	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:158435857A>T	uc010pij.1	+	1	506	c.506A>T	c.(505-507)CAC>CTC	p.H169L		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CTGCCCTTCCACTCCTCCAAC	0.532000												
SPTA1	6708	broad.mit.edu	37	1	158622345	158622345	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:158622345T>C	uc001fst.1	-	23	3486	c.3287A>G	c.(3286-3288)GAA>GGA	p.E1096G		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1096	Spectrin 11.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTGAATCCATTCCAGCATGTC	0.443000												
SPTA1	6708	broad.mit.edu	37	1	158653164	158653164	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:158653164C>T	uc001fst.1	-	3	586	c.387G>A	c.(385-387)ACG>ACA	p.T129T		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	129	Spectrin 2.			Missing (in Ref. 3; AAA60575).	actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CATATACCTTCGTTTCTTCGT	0.393000												
OR6N2	81442	broad.mit.edu	37	1	158747232	158747232	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:158747232A>C	uc010pir.1	-	1	194	c.194T>G	c.(193-195)GTT>GGT	p.V65G		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					GAAGGAAAGAACACTGACAAA	0.438000												
KIAA1614	57710	broad.mit.edu	37	1	180910330	180910330	+	Missense_Mutation	SNP	A	A	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:180910330A>T	uc001gok.2	+	7	3135	c.3068A>T	c.(3067-3069)AAG>ATG	p.K1023M	KIAA1614_uc001gol.1_Missense_Mutation_p.K644M|KIAA1614_uc001gom.1_Missense_Mutation_p.K114M	NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	1023	Ser-rich.									ovary(3)|skin(1)	4						AAGCTGGGCAAGTCCCGCAGC	0.622000												
HSD11B1	3290	broad.mit.edu	37	1	209905907	209905907	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:209905907T>C	uc001hhj.2	+	6	751	c.644T>C	c.(643-645)CTT>CCT	p.L215P	HSD11B1_uc001hhk.2_Missense_Mutation_p.L215P	NM_181755	NP_861420	P28845	DHI1_HUMAN	11-beta-hydroxysteroid dehydrogenase 1	215	Lumenal (Potential).				glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase (NADP+) activity|11-beta-hydroxysteroid dehydrogenase|binding			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	CTCTGTGTTCTTGGCCTCATA	0.299000												
LEFTY1	10637	broad.mit.edu	37	1	226074671	226074671	+	Missense_Mutation	SNP	G	G	A	rs146082781		TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:226074671G>A	uc001hpo.2	-	4	927	c.857C>T	c.(856-858)CCG>CTG	p.P286L	LEFTY1_uc010pvj.1_3'UTR	NM_020997	NP_066277	O75610	LFTY1_HUMAN	left-right determination, factor B	286					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					CAGGAAGCCCGGGGGCTCCAG	0.662000												
ZNF695	57116	broad.mit.edu	37	1	247150278	247150278	+	Silent	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:247150278A>G	uc009xgu.2	-	4	1684	c.1539T>C	c.(1537-1539)ACT>ACC	p.T513T	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron|ZNF695_uc009xgt.1_Intron|ZNF695_uc001ibx.2_Intron|ZNF695_uc001iby.2_Intron	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	513	C2H2-type 13.				regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTCAGGTATGAGTTTTCTCAT	0.353000												
OR2G3	81469	broad.mit.edu	37	1	247769183	247769183	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:247769183C>T	uc010pyz.1	+	1	296	c.296C>T	c.(295-297)GCG>GTG	p.A99V		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GGTTGTGTGGCGCAACTCTAT	0.483000												
OR6F1	343169	broad.mit.edu	37	1	247875925	247875925	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:247875925T>A	uc001idj.1	-	1	133	c.133A>T	c.(133-135)ATC>TTC	p.I45F		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	45	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AACATCAAGATAGCCACATTA	0.458000												
OR2T4	127074	broad.mit.edu	37	1	248525571	248525571	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:248525571T>A	uc001ieh.1	+	1	689	c.689T>A	c.(688-690)TTC>TAC	p.F230Y		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	230	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TATGAGATTTTCATGTACTTG	0.478000												
SH3BP5L	80851	broad.mit.edu	37	1	249107243	249107243	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr1:249107243A>C	uc001iew.1	-	6	1208	c.656T>G	c.(655-657)ATC>AGC	p.I219S	SH3BP5L_uc010pzp.1_Missense_Mutation_p.I112S|SH3BP5L_uc010pzq.1_Missense_Mutation_p.I187S|SH3BP5L_uc001iev.1_Missense_Mutation_p.I100S	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	219	Potential.										0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GCTCTTGCCGATGGCCCTCCG	0.652000												
USP6NL	9712	broad.mit.edu	37	10	11505274	11505274	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr10:11505274G>A	uc001ikt.3	-	15	1974	c.1653C>T	c.(1651-1653)TAC>TAT	p.Y551Y	USP6NL_uc001iks.1_Silent_p.Y568Y	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	551						intracellular	Rab GTPase activator activity				0						GCACGTTGTCGTACTGCGATG	0.662000												
CUBN	8029	broad.mit.edu	37	10	17087075	17087075	+	Silent	SNP	G	G	A	rs112675306	byFrequency	TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr10:17087075G>A	uc001ioo.2	-	25	3655	c.3603C>T	c.(3601-3603)AGC>AGT	p.S1201S		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1201	CUB 7.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTTCAAATGCGCTGCCGTGGC	0.448000												
SLC39A12	221074	broad.mit.edu	37	10	18242152	18242152	+	Translation_Start_Site	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr10:18242152C>T	uc001ipo.2	+	2	220	c.-53C>T	c.(-55--51)AACGG>AATGG		SLC39A12_uc001ipn.2_Translation_Start_Site|SLC39A12_uc001ipp.2_Translation_Start_Site|SLC39A12_uc010qck.1_Intron	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),						zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						ACCCCATAAACGGCAACACAC	0.433000												
ZNF438	220929	broad.mit.edu	37	10	31138579	31138579	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr10:31138579G>C	uc010qdz.1	-	7	1190	c.755C>G	c.(754-756)TCT>TGT	p.S252C	ZNF438_uc001ivn.2_Missense_Mutation_p.S203C|ZNF438_uc010qdy.1_Missense_Mutation_p.S242C|ZNF438_uc001ivo.3_Intron|ZNF438_uc009xlg.2_Missense_Mutation_p.S252C|ZNF438_uc001ivp.3_Missense_Mutation_p.S242C|ZNF438_uc010qea.1_Missense_Mutation_p.S252C|ZNF438_uc010qeb.1_Missense_Mutation_p.S252C|ZNF438_uc010qec.1_Intron	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				GGCAACAGCAGAAGGTTTACT	0.433000												
DKK1	22943	broad.mit.edu	37	10	54076525	54076525	+	Missense_Mutation	SNP	A	A	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr10:54076525A>T	uc001jjr.2	+	4	913	c.759A>T	c.(757-759)CAA>CAT	p.Q253H	uc001jjq.1_5'Flank|uc009xox.1_5'Flank	NM_012242	NP_036374	O94907	DKK1_HUMAN	dickkopf homolog 1 precursor	253	DKK-type Cys-2.				negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						ATCACCATCAAGCCAGTAATT	0.408000												
PCDH15	65217	broad.mit.edu	37	10	56106146	56106146	+	Silent	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr10:56106146A>G	uc001jju.1	-	6	968	c.573T>C	c.(571-573)ATT>ATC	p.I191I	PCDH15_uc010qhq.1_Silent_p.I196I|PCDH15_uc010qhr.1_Silent_p.I191I|PCDH15_uc010qhs.1_Silent_p.I196I|PCDH15_uc010qht.1_Silent_p.I191I|PCDH15_uc010qhu.1_Silent_p.I191I|PCDH15_uc001jjv.1_Silent_p.I169I|PCDH15_uc010qhv.1_Silent_p.I191I|PCDH15_uc010qhw.1_Silent_p.I191I|PCDH15_uc010qhx.1_Silent_p.I191I|PCDH15_uc010qhy.1_Silent_p.I196I|PCDH15_uc010qhz.1_Silent_p.I191I|PCDH15_uc010qia.1_Silent_p.I169I|PCDH15_uc010qib.1_Silent_p.I169I|PCDH15_uc001jjw.2_Silent_p.I191I	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	191	Extracellular (Potential).|Cadherin 2.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GATTATACTGAATAACATACT	0.328000										HNSCC(58;0.16)		
EXOC6	54536	broad.mit.edu	37	10	94816716	94816716	+	Silent	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr10:94816716T>G	uc001kig.2	+	21	2271	c.2205T>G	c.(2203-2205)ACT>ACG	p.T735T	EXOC6_uc010qnr.1_Silent_p.T751T|EXOC6_uc001kie.2_Silent_p.T730T|EXOC6_uc009xub.2_Silent_p.T734T|EXOC6_uc009xuc.2_Silent_p.T632T|EXOC6_uc001kih.2_RNA|EXOC6_uc001kii.2_Silent_p.T309T	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	735					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				ATTGGTCTACTTACCTAGCTG	0.383000												
C10orf76	79591	broad.mit.edu	37	10	103789493	103789493	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr10:103789493C>T	uc009xwy.1	-	5	418	c.316G>A	c.(316-318)GCA>ACA	p.A106T	C10orf76_uc001kui.2_Missense_Mutation_p.A106T	NM_024541	NP_078817	Q5T2E6	CJ076_HUMAN	hypothetical protein LOC79591	106						integral to membrane					0		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		CGAATGAGTGCGCACAGGGTC	0.478000												
OR51D1	390038	broad.mit.edu	37	11	4661487	4661487	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:4661487A>G	uc010qyk.1	+	1	467	c.467A>G	c.(466-468)AAG>AGG	p.K156R		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACTGTGGCCAAGATTGGACTA	0.537000												
RBMXL2	27288	broad.mit.edu	37	11	7111100	7111100	+	Missense_Mutation	SNP	A	A	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:7111100A>T	uc001mfc.2	+	1	936	c.749A>T	c.(748-750)GAC>GTC	p.D250V		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	250	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGTGTCCGGGACGACTGTCCC	0.642000												
C11orf16	56673	broad.mit.edu	37	11	8948637	8948637	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:8948637C>T	uc001mhb.3	-	4	533	c.409G>A	c.(409-411)GTC>ATC	p.V137I	C11orf16_uc001mhc.3_Missense_Mutation_p.V137I	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	137										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		TCTTCTAAGACCACTCTCTGC	0.557000												
PIK3C2A	5286	broad.mit.edu	37	11	17190765	17190765	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:17190765C>A	uc001mmq.3	-	1	590	c.524G>T	c.(523-525)AGA>ATA	p.R175I	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Intron|PIK3C2A_uc001mmr.3_RNA|PIK3C2A_uc010rcx.1_Missense_Mutation_p.R175I|PIK3C2A_uc009ygv.1_Missense_Mutation_p.R175I	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	175					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	AGTGGGCATTCTTGGATTGAA	0.423000												
KCNA4	3739	broad.mit.edu	37	11	30033552	30033552	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:30033552C>T	uc001msk.2	-	2	1826	c.674G>A	c.(673-675)CGC>CAC	p.R225H		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	225						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AAAGCTGGGGCGGTTCCTGTC	0.468000												
PAMR1	25891	broad.mit.edu	37	11	35454060	35454060	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:35454060C>T	uc001mwg.2	-	11	2050	c.2007G>A	c.(2005-2007)GCG>GCA	p.A669A	PAMR1_uc001mwf.2_Silent_p.A686A|PAMR1_uc010rew.1_Silent_p.A558A|PAMR1_uc010rex.1_Silent_p.A629A	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	669	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						AGGACACAGCCGCGATGCCTC	0.567000												
RAG1	5896	broad.mit.edu	37	11	36595248	36595248	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:36595248C>T	uc001mwu.3	+	2	518	c.394C>T	c.(394-396)CCT>TCT	p.P132S	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	132	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				AGTCCATGGTCCTGTGGATGG	0.498000									Familial_Hemophagocytic_Lymphohistiocytosis			
ACCSL	390110	broad.mit.edu	37	11	44072941	44072941	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:44072941T>G	uc001mxw.1	+	4	748	c.692T>G	c.(691-693)CTT>CGT	p.L231R	ACCSL_uc009ykr.2_Missense_Mutation_p.L50R	NM_001031854	NP_001027025	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase	231							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(5)	5						CCTACCCGACTTGACCCAGAA	0.572000												
TRIM48	79097	broad.mit.edu	37	11	55033158	55033158	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:55033158T>G	uc010rid.1	+	3	628	c.542T>G	c.(541-543)ATC>AGC	p.I181S		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	165						intracellular	zinc ion binding				0						ACCACCAGAATCAGCCACTGG	0.403000												
OR4A16	81327	broad.mit.edu	37	11	55110805	55110805	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:55110805T>G	uc010rie.1	+	1	129	c.129T>G	c.(127-129)ATT>ATG	p.I43M		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						ACCTCCTCATTTGGGTGACTA	0.438000												
OR4C15	81309	broad.mit.edu	37	11	55322161	55322161	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:55322161T>A	uc010rig.1	+	1	379	c.379T>A	c.(379-381)TCA>ACA	p.S127T		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGCGTGCTTCTCATCTGTCAT	0.458000										HNSCC(20;0.049)		
FAM111A	63901	broad.mit.edu	37	11	58919986	58919986	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:58919986C>T	uc010rkp.1	+	5	1072	c.845C>T	c.(844-846)CCT>CTT	p.P282L	FAM111A_uc010rkq.1_Missense_Mutation_p.P282L|FAM111A_uc010rkr.1_Missense_Mutation_p.P282L|FAM111A_uc001nno.2_Missense_Mutation_p.P282L|FAM111A_uc001nnp.2_Missense_Mutation_p.P282L|FAM111A_uc001nnq.2_Missense_Mutation_p.P282L	NM_001142521	NP_001135993	Q96PZ2	F111A_HUMAN	hypothetical protein LOC63901	282					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_epithelial(135;0.139)				TCTCAGAATCCTGAGTCAGAG	0.413000												
VEGFB	7423	broad.mit.edu	37	11	64003329	64003329	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:64003329C>T	uc001nyw.2	+	3	188	c.148C>T	c.(148-150)CGG>TGG	p.R50W	VEGFB_uc001nyx.2_Missense_Mutation_p.R50W	NM_003377	NP_003368	P49765	VEGFB_HUMAN	vascular endothelial growth factor B precursor	50					anti-apoptosis|induction of positive chemotaxis|negative regulation of gene expression|negative regulation of neuron apoptosis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular wound healing|vascular endothelial growth factor receptor signaling pathway	extracellular region|extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|heparin binding|vascular endothelial growth factor receptor 1 binding				0						CTGCCAGCCCCGGGAGGTGGT	0.622000												
PACS1	55690	broad.mit.edu	37	11	65984206	65984206	+	Missense_Mutation	SNP	A	A	C	rs12798701		TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:65984206A>C	uc001oha.1	+	7	1072	c.938A>C	c.(937-939)AAG>ACG	p.K313T	PACS1_uc001ogz.1_Missense_Mutation_p.K313T	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	313					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						AAAGTGAAGAAGACCCGGAGG	0.532000												
CABP4	57010	broad.mit.edu	37	11	67223083	67223083	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:67223083C>T	uc001olo.2	+	1	266	c.189C>T	c.(187-189)GGC>GGT	p.G63G	GPR152_uc001olm.2_5'Flank|CABP4_uc001oln.2_Intron	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	63					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			AGCAGACAGGCCCCGAGGCCC	0.697000												
CNTN5	53942	broad.mit.edu	37	11	99827705	99827705	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:99827705C>T	uc001pga.2	+	8	1180	c.841C>T	c.(841-843)CTT>TTT	p.L281F	CNTN5_uc009ywv.1_Missense_Mutation_p.L281F|CNTN5_uc001pfz.2_Missense_Mutation_p.L281F|CNTN5_uc001pgb.2_Missense_Mutation_p.L207F	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	281	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TGCTAGAGTCCTTAGTCCTCC	0.418000												
ARHGAP20	57569	broad.mit.edu	37	11	110451103	110451103	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:110451103T>A	uc001pkz.1	-	16	2852	c.2567A>T	c.(2566-2568)AAG>ATG	p.K856M	ARHGAP20_uc001pky.1_Missense_Mutation_p.K833M|ARHGAP20_uc009yyb.1_Missense_Mutation_p.K820M|ARHGAP20_uc001pla.1_Missense_Mutation_p.K820M|ARHGAP20_uc001plb.2_Missense_Mutation_p.K399M	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	856					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		ATAGGTCAGCTTGCGGTTCTG	0.488000												
HTR3B	9177	broad.mit.edu	37	11	113815433	113815433	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:113815433A>G	uc001pok.2	+	8	1113	c.1046A>G	c.(1045-1047)GAC>GGC	p.D349G	HTR3B_uc001pol.2_Missense_Mutation_p.D338G	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	349	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		ACCGATGCTGACAGGCCTAGA	0.532000												
MLL	4297	broad.mit.edu	37	11	118343719	118343719	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:118343719G>A	uc001pta.2	+	3	1868	c.1845G>A	c.(1843-1845)CCG>CCA	p.P615P	MLL_uc001ptb.2_Silent_p.P615P|MLL_uc001psz.1_Silent_p.P648P|MLL_uc001ptd.1_Intron	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	615					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TGCGAGAACCGACATTTAGGT	0.433000			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL							
UPK2	7379	broad.mit.edu	37	11	118828883	118828883	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:118828883C>T	uc001puh.2	+	5	530	c.495C>T	c.(493-495)GTC>GTT	p.V165V		NM_006760	NP_006751	O00526	UPK2_HUMAN	uroplakin 2 precursor	165	Helical; (Potential).				cellular membrane organization|epithelial cell differentiation|multicellular organismal development	integral to endoplasmic reticulum membrane|integral to plasma membrane				skin(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.122)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.47e-05)		TGCTCTCTGTCGCCATGTTCC	0.607000												
DDX11	1663	broad.mit.edu	37	12	31254031	31254031	+	Silent	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr12:31254031A>G	uc001rjt.1	+	20	2270	c.2019A>G	c.(2017-2019)GAA>GAG	p.E673E	DDX11_uc001rjr.1_Silent_p.E673E|DDX11_uc001rjs.1_Silent_p.E673E|DDX11_uc001rju.1_Silent_p.E345E|DDX11_uc001rjv.1_Silent_p.E673E|DDX11_uc001rjw.1_Silent_p.E647E|DDX11_uc009zjn.1_RNA|DDX11_uc009zjo.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	673					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					AGCCGCTGGAATTCACGTTCC	0.607000										Multiple Myeloma(12;0.14)		
CNTN1	1272	broad.mit.edu	37	12	41323661	41323661	+	Missense_Mutation	SNP	G	G	A	rs4408370		TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr12:41323661G>A	uc001rmm.1	+	7	673	c.560G>A	c.(559-561)CGA>CAA	p.R187Q	CNTN1_uc009zjy.1_Missense_Mutation_p.R187Q|CNTN1_uc001rmn.1_Missense_Mutation_p.R176Q|CNTN1_uc001rmo.2_Missense_Mutation_p.R187Q	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	187	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GATAAACGGCGATTTGTGTCT	0.368000												
TMEM194A	23306	broad.mit.edu	37	12	57454643	57454643	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr12:57454643G>A	uc001smy.2	-	8	1112	c.1066C>T	c.(1066-1068)CGA>TGA	p.R356*	TMEM194A_uc001smx.2_Nonsense_Mutation_p.R283*|TMEM194A_uc010sra.1_Nonsense_Mutation_p.R97*	NM_001130963	NP_001124435	O14524	T194A_HUMAN	transmembrane protein 194A isoform a	356						integral to membrane					0						AAAGCCTTTCGGGTTTCTACC	0.478000												
LRP1	4035	broad.mit.edu	37	12	57589508	57589508	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr12:57589508C>T	uc001snd.2	+	53	8971	c.8505C>T	c.(8503-8505)TTC>TTT	p.F2835F		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2835	LDL-receptor class A 18.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCAAGCACTTCGTGTGTGACC	0.622000												
RNF34	80196	broad.mit.edu	37	12	121861308	121861308	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr12:121861308G>A	uc001ual.1	+	6	1162	c.1048G>A	c.(1048-1050)GGC>AGC	p.G350S	RNF34_uc001uak.1_Missense_Mutation_p.G351S|RNF34_uc001uam.1_Missense_Mutation_p.G350S	NM_025126	NP_079402	Q969K3	RNF34_HUMAN	ring finger protein 34 isoform 2	350	RING-type.				apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)		CACCAAGTGCGGCAAGCGCAT	0.587000												
DNAH10	196385	broad.mit.edu	37	12	124409641	124409641	+	Silent	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr12:124409641T>G	uc001uft.3	+	67	11482	c.11457T>G	c.(11455-11457)GGT>GGG	p.G3819G	DNAH10_uc001ufu.3_5'UTR	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3819	TPR 4.				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCCCCTTGGGTTACGATAACA	0.478000												
EP400	57634	broad.mit.edu	37	12	132446433	132446433	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr12:132446433G>A	uc001ujn.2	+	1	1304	c.1269G>A	c.(1267-1269)TTG>TTA	p.L423L	EP400_uc001ujl.2_Silent_p.L423L|EP400_uc001ujm.2_Silent_p.L423L|EP400_uc001ujj.1_Silent_p.L423L|EP400_uc001ujk.2_Silent_p.L423L	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	423					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		AGAATGATTTGGACATTgaag	0.279000												
ATP12A	479	broad.mit.edu	37	13	25281524	25281524	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr13:25281524C>A	uc001upp.2	+	17	2633	c.2446C>A	c.(2446-2448)CCC>ACC	p.P816T	ATP12A_uc010aaa.2_Missense_Mutation_p.P822T	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	816	Lumenal (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GCTCCCCCTGCCCATTGGCAC	0.512000												
MTMR6	9107	broad.mit.edu	37	13	25825882	25825882	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr13:25825882G>A	uc001uqf.3	-	13	1829	c.1510C>T	c.(1510-1512)CGA>TGA	p.R504*	MTMR6_uc001uqe.1_Nonsense_Mutation_p.R504*	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	504						cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		TGCAGTGTTCGATCAAATTGA	0.284000												
RASL11A	387496	broad.mit.edu	37	13	27847280	27847280	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr13:27847280C>T	uc001urd.1	+	4	996	c.378C>T	c.(376-378)CCC>CCT	p.P126P		NM_206827	NP_996563	Q6T310	RSLBA_HUMAN	RAS-like, family 11, member A	126	Small GTPase-like.				positive regulation of transcription from RNA polymerase I promoter|small GTPase mediated signal transduction|transcription, DNA-dependent	membrane|nucleolus	GTP binding|GTPase activity			breast(1)	1		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0173)|GBM - Glioblastoma multiforme(144;0.0557)|OV - Ovarian serous cystadenocarcinoma(117;0.152)|Epithelial(112;0.164)		CCATCCGACCCCTTTATCAGC	0.562000												
DCLK1	9201	broad.mit.edu	37	13	36521533	36521533	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr13:36521533T>G	uc001uvf.2	-	4	1018	c.785A>C	c.(784-786)AAG>ACG	p.K262T		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	262	Doublecortin 2.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GTAACGGAACTTCTCCGGTCC	0.423000												
PCDH20	64881	broad.mit.edu	37	13	61985723	61985723	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr13:61985723C>A	uc001vid.3	-	2	2873	c.2509G>T	c.(2509-2511)GTC>TTC	p.V837F	PCDH20_uc010thj.1_Missense_Mutation_p.V837F	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	810	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TTCACCATGACTGTGGAGTGG	0.423000												
LMO7	4008	broad.mit.edu	37	13	76408425	76408425	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr13:76408425A>G	uc001vjv.2	+	14	3189	c.2429A>G	c.(2428-2430)AAG>AGG	p.K810R	LMO7_uc010thv.1_Missense_Mutation_p.K761R|LMO7_uc001vjt.1_Missense_Mutation_p.K709R|LMO7_uc010thw.1_Missense_Mutation_p.K660R|LMO7_uc001vjw.1_Missense_Mutation_p.K716R	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	1095	PDZ.					cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AACAACACCAAGTTTTCATAT	0.393000												
SLITRK5	26050	broad.mit.edu	37	13	88328385	88328385	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr13:88328385G>T	uc001vln.2	+	2	961	c.742G>T	c.(742-744)GAT>TAT	p.D248Y	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	248	LRRCT 1.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CTCTCTAAAGGATTGGTTGGA	0.517000												
DZIP1	22873	broad.mit.edu	37	13	96251664	96251664	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr13:96251664A>G	uc001vmk.2	-	15	2344	c.1492T>C	c.(1492-1494)TCG>CCG	p.S498P	DZIP1_uc001vmj.2_5'UTR|DZIP1_uc001vml.2_Missense_Mutation_p.S479P	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	498					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			AGTATGTGCGACGAGAATGCC	0.343000												
ZIC2	7546	broad.mit.edu	37	13	100637296	100637296	+	Missense_Mutation	SNP	A	A	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr13:100637296A>T	uc001von.2	+	2	1172	c.1172A>T	c.(1171-1173)AAG>ATG	p.K391M		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	391					brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ACCTCCGATAAGCCCTATCTC	0.627000												
HEATR5A	25938	broad.mit.edu	37	14	31852827	31852827	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr14:31852827T>C	uc001wrf.3	-	4	694	c.617A>G	c.(616-618)AAG>AGG	p.K206R	HEATR5A_uc010ami.2_Missense_Mutation_p.K104R|HEATR5A_uc001wrg.1_Missense_Mutation_p.K88R|HEATR5A_uc010tpk.1_Missense_Mutation_p.K499R	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	493							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		AGGTGAAGACTTATGTCCAGT	0.478000												
FAM177A1	283635	broad.mit.edu	37	14	35546406	35546406	+	Silent	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr14:35546406T>G	uc001wsp.2	+	5	780	c.321T>G	c.(319-321)GCT>GCG	p.A107A	FAM177A1_uc001wsq.2_Silent_p.A130A	NM_001079519	NP_001072987	Q8N128	F177A_HUMAN	hypothetical protein LOC283635 isoform 2	107											0						TTCGGGCTGCTACATCAACTC	0.378000												
ABHD12B	145447	broad.mit.edu	37	14	51352350	51352350	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr14:51352350T>G	uc001wys.2	+	6	520	c.505T>G	c.(505-507)TTT>GTT	p.F169V	ABHD12B_uc001wyq.2_Missense_Mutation_p.F62V|ABHD12B_uc001wyr.2_Missense_Mutation_p.F92V|ABHD12B_uc010any.2_Intron	NM_181533	NP_853511	Q7Z5M8	AB12B_HUMAN	abhydrolase domain containing 12B isoform b	169							hydrolase activity			breast(1)	1	all_epithelial(31;0.00481)|Breast(41;0.148)					TGATGGTGGCTTTCATGTCTT	0.428000												
CGRRF1	10668	broad.mit.edu	37	14	55004833	55004833	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr14:55004833C>A	uc001xay.2	+	6	822	c.731C>A	c.(730-732)TCA>TAA	p.S244*	CGRRF1_uc001xaz.2_RNA	NM_006568	NP_006559	Q99675	CGRF1_HUMAN	cell growth regulator with ring finger domain 1	244					cell cycle arrest|negative regulation of cell proliferation|response to stress		zinc ion binding			ovary(1)	1						AATTCCTCTTCAGAAGAAAAA	0.338000												
C14orf135	64430	broad.mit.edu	37	14	60581727	60581727	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr14:60581727C>A	uc001xer.3	+	3	725	c.203C>A	c.(202-204)GCT>GAT	p.A68D	C14orf135_uc001xeq.2_Missense_Mutation_p.A68D	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	302						integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		GCTGGAACAGCTATAGCATCA	0.318000												
SIX6	4990	broad.mit.edu	37	14	60976191	60976191	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr14:60976191C>T	uc001xfa.3	+	1	254	c.75C>T	c.(73-75)GGC>GGT	p.G25G		NM_007374	NP_031400	O95475	SIX6_HUMAN	SIX homeobox 6	25					organ morphogenesis|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.088)		AAGAGAGCGGCGATGTGGAGC	0.667000												
KCNH5	27133	broad.mit.edu	37	14	63175038	63175038	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr14:63175038G>T	uc001xfx.2	-	11	2206	c.2155C>A	c.(2155-2157)CTG>ATG	p.L719M	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	719	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TGATTCCGCAGCTCCTTCTGC	0.582000												
KCNH5	27133	broad.mit.edu	37	14	63511893	63511893	+	Silent	SNP	G	G	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr14:63511893G>T	uc001xfx.2	-	1	63	c.12C>A	c.(10-12)GGC>GGA	p.G4G	KCNH5_uc001xfy.2_Silent_p.G4G|KCNH5_uc001xfz.1_Intron|KCNH5_uc001xga.2_Intron	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	4	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GCCCTCTCTTGCCCCCCGGCA	0.433000												
ALDH6A1	4329	broad.mit.edu	37	14	74538929	74538929	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr14:74538929G>C	uc001xpo.2	-	4	424	c.325C>G	c.(325-327)CAA>GAA	p.Q109E	C14orf45_uc001xpm.1_Intron|ALDH6A1_uc010asa.2_Translation_Start_Site|ALDH6A1_uc010tuq.1_Intron	NM_005589	NP_005580	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6A1 precursor	109						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	ATAAGTTGTTGATAGCGGAGC	0.448000												
C14orf115	55237	broad.mit.edu	37	14	74824717	74824717	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr14:74824717C>A	uc001xpw.3	+	2	1422	c.1231C>A	c.(1231-1233)CAT>AAT	p.H411N		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	411					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		GTACCTGGAGCATTGCATCTC	0.577000												
GPR132	29933	broad.mit.edu	37	14	105518248	105518248	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr14:105518248C>G	uc001yqd.2	-	4	1125	c.226G>C	c.(226-228)GTG>CTG	p.V76L	GPR132_uc001yqc.2_5'UTR|GPR132_uc001yqe.2_Missense_Mutation_p.V67L	NM_013345	NP_037477	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	76	Cytoplasmic (Potential).				response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		ACGGCCAGCACGTTGCCCTGC	0.647000												
ZNF770	54989	broad.mit.edu	37	15	35275478	35275478	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr15:35275478T>C	uc001ziw.2	-	3	469	c.158A>G	c.(157-159)AAG>AGG	p.K53R		NM_014106	NP_054825	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		TTCAAATGGCTTTTGACCAGT	0.348000												
FAM82A2	55177	broad.mit.edu	37	15	41043711	41043711	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr15:41043711C>T	uc001zmo.1	-	4	581	c.437G>A	c.(436-438)CGG>CAG	p.R146Q	FAM82A2_uc001zmp.1_Missense_Mutation_p.R146Q|FAM82A2_uc001zmq.1_Missense_Mutation_p.R146Q	NM_018145	NP_060615	Q96TC7	RMD3_HUMAN	family with sequence similarity 82, member A2	146					apoptosis|cell differentiation	integral to membrane|microtubule|mitochondrial membrane|nucleus|spindle pole	protein binding				0						ACTCCTCTCCCGGACAAACGG	0.587000												
EIF3J	8669	broad.mit.edu	37	15	44846861	44846861	+	Silent	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr15:44846861T>G	uc001ztv.2	+	5	532	c.405T>G	c.(403-405)ACT>ACG	p.T135T	EIF3J_uc010ueg.1_Silent_p.T135T|EIF3J_uc001ztw.2_Silent_p.T86T	NM_003758	NP_003749	O75822	EIF3J_HUMAN	eukaryotic translation initiation factor 3,	135	Potential.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity				0		all_cancers(109;2.81e-14)|all_epithelial(112;2.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;3.13e-20)|GBM - Glioblastoma multiforme(94;9.81e-07)|COAD - Colon adenocarcinoma(120;0.0754)|Colorectal(105;0.0758)		CAAAGGAAACTTTTGGTAAGA	0.373000												
ADAMTSL3	57188	broad.mit.edu	37	15	84705590	84705590	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr15:84705590A>C	uc002bjz.3	+	29	5044	c.4820A>C	c.(4819-4821)AAG>ACG	p.K1607T	ADAMTSL3_uc010bmu.1_Missense_Mutation_p.K1607T	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1607	TSP type-1 10.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGCCCTTGGAAGCCCTGTACA	0.498000												
ALPK3	57538	broad.mit.edu	37	15	85383024	85383024	+	Missense_Mutation	SNP	A	A	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr15:85383024A>T	uc002ble.2	+	5	1287	c.1120A>T	c.(1120-1122)ATG>TTG	p.M374L		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	374					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGTGGGCACCATGACTGAGTA	0.592000												
FANCI	55215	broad.mit.edu	37	15	89828380	89828380	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr15:89828380C>T	uc010bnp.1	+	18	1842	c.1752C>T	c.(1750-1752)TGC>TGT	p.C584C	FANCI_uc002bnm.1_Silent_p.C584C|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Silent_p.C405C|FANCI_uc002bnq.1_5'UTR	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	584					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					AAACTTTTTGCCTTGAGATCA	0.418000								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia			
BLM	641	broad.mit.edu	37	15	91306363	91306363	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr15:91306363G>T	uc002bpr.2	+	8	2147	c.2050G>T	c.(2050-2052)GAC>TAC	p.D684Y	BLM_uc010uqh.1_Missense_Mutation_p.D684Y|BLM_uc010uqi.1_Missense_Mutation_p.D309Y|BLM_uc010bnx.2_Missense_Mutation_p.D684Y|BLM_uc002bps.1_Missense_Mutation_p.D246Y	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	684	Helicase ATP-binding.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			GCTTGGTGAAGACTGTTTTAT	0.343000			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome			
C16orf63	123811	broad.mit.edu	37	16	15978053	15978053	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr16:15978053T>C	uc002dec.1	-	2	43	c.38A>G	c.(37-39)GAC>GGC	p.D13G	C16orf63_uc002ded.1_Missense_Mutation_p.D13G	NM_144600	NP_653201	Q96NB1	FOPNL_HUMAN	hypothetical protein LOC123811	13	Necessary and sufficient for homooligomerization and localization to centrosomes and pericentriolar satellites.				cilium assembly|microtubule anchoring	centriolar satellite|microtubule basal body|motile cilium	identical protein binding				0						TTCCAAGGTGTCCTTTAAAAC	0.373000												
ZNF48	197407	broad.mit.edu	37	16	30409955	30409955	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr16:30409955C>T	uc002dya.1	+	2	1443	c.1384C>T	c.(1384-1386)CGA>TGA	p.R462*	ZNF48_uc002dxz.1_Nonsense_Mutation_p.R339*	NM_152652	NP_689865	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	462	Pro-rich.|C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGGCTTCCGCCGAAGCTCTGA	0.637000												
SRCAP	10847	broad.mit.edu	37	16	30732561	30732561	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr16:30732561C>T	uc002dze.1	+	21	3690	c.3305C>T	c.(3304-3306)CCA>CTA	p.P1102L	SRCAP_uc002dzf.2_Intron|SRCAP_uc002dzg.1_Missense_Mutation_p.P959L|SRCAP_uc010bzz.1_Missense_Mutation_p.P672L	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1102	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CCTCCCACGCCAACCTTGTCC	0.602000												
HEATR3	55027	broad.mit.edu	37	16	50102711	50102711	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr16:50102711G>T	uc002efw.2	+	3	494	c.332G>T	c.(331-333)GGT>GTT	p.G111V	HEATR3_uc002efx.2_Missense_Mutation_p.G25V	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	111							binding			ovary(1)|skin(1)	2						GCTTGTGGAGGTTTTGAAGTT	0.383000												
CHD9	80205	broad.mit.edu	37	16	53191212	53191212	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr16:53191212T>G	uc002ehb.2	+	1	1375	c.1211T>G	c.(1210-1212)CTT>CGT	p.L404R	CHD9_uc002egy.2_Missense_Mutation_p.L404R|CHD9_uc002egz.1_Missense_Mutation_p.L404R|CHD9_uc002eha.1_Missense_Mutation_p.L404R|CHD9_uc002ehc.2_Missense_Mutation_p.L404R	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	404					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TTCACAGGACTTGACCCCGAG	0.403000												
EXOC3L	283849	broad.mit.edu	37	16	67223060	67223060	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr16:67223060G>A	uc002erx.1	-	3	311	c.70C>T	c.(70-72)CGG>TGG	p.R24W	EXOC3L_uc002erv.1_RNA|EXOC3L_uc002erw.1_5'UTR|EXOC3L_uc002ery.1_Missense_Mutation_p.R29W|EXOC3L_uc010vje.1_Missense_Mutation_p.R24W	NM_178516	NP_848611	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like	24	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0021)|Epithelial(162;0.0073)|all cancers(182;0.0616)		TGCTCTGCCCGCTCCTGCTCT	0.657000												
HYDIN	54768	broad.mit.edu	37	16	70977783	70977783	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr16:70977783C>T	uc002ezr.2	-	42	6726	c.6598G>A	c.(6598-6600)GAG>AAG	p.E2200K		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2201										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				AGCCCGGTCTCGCCTCCGACA	0.522000												
BCMO1	53630	broad.mit.edu	37	16	81324114	81324114	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr16:81324114A>C	uc002fgn.1	+	11	1794	c.1576A>C	c.(1576-1578)AAA>CAA	p.K526Q	BCMO1_uc010vnp.1_Missense_Mutation_p.K457Q	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	526					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						CTGGGACACAAAAAAGCAGGC	0.547000												
MBTPS1	8720	broad.mit.edu	37	16	84126890	84126890	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr16:84126890C>G	uc002fhi.2	-	6	1251	c.749G>C	c.(748-750)GGC>GCC	p.G250A		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	250	Serine protease.|Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						CACGAATGTGCCATGGCCCAA	0.488000												
ITGAE	3682	broad.mit.edu	37	17	3661134	3661134	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:3661134T>G	uc002fwo.3	-	9	985	c.886A>C	c.(886-888)AGC>CGC	p.S296R		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	296	VWFA.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		GAGCCGTGGCTTGAGGTGAAG	0.527000												
ZZEF1	23140	broad.mit.edu	37	17	3992174	3992174	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:3992174T>G	uc002fxe.2	-	13	2103	c.2039A>C	c.(2038-2040)AAG>ACG	p.K680T	ZZEF1_uc002fxk.1_Missense_Mutation_p.K680T	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	680							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GCAGAGGAACTTCACCATCAA	0.502000												
TP53	7157	broad.mit.edu	37	17	7579472	7579472	+	Missense_Mutation	SNP	G	G	C	rs1042522	byFrequency	TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:7579472G>C	uc002gim.2	-	4	409	c.215C>G	c.(214-216)CCC>CGC	p.P72R	TP53_uc002gig.1_Missense_Mutation_p.P72R|TP53_uc002gih.2_Missense_Mutation_p.P72R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.P72R|TP53_uc010cni.1_Missense_Mutation_p.P72R|TP53_uc002gij.2_Missense_Mutation_p.P72R|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.P33R|TP53_uc010cnk.1_Missense_Mutation_p.P87R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	72	Interaction with WWOX.|Interaction with HRMT1L2.		P -> C (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> L (in a sporadic cancer; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> G (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.R72fs*51(6)|p.G59fs*23(3)|p.R72C(2)|p.R72H(2)|p.E68fs*76(1)|p.D48fs*55(1)|p.P13fs*18(1)|p.R65fs*38(1)|p.D57_A76del20(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGGGCCACGGGGGGAGCAGC	0.607000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
DNAH2	146754	broad.mit.edu	37	17	7701486	7701486	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:7701486G>A	uc002giu.1	+	53	8256	c.8242G>A	c.(8242-8244)GTG>ATG	p.V2748M		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2748	AAA 4 (By similarity).|TPR 2.				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CACACGGATCGTGCGGGTCAT	0.637000												
MYH8	4626	broad.mit.edu	37	17	10303844	10303844	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:10303844C>T	uc002gmm.2	-	27	3693	c.3598G>A	c.(3598-3600)GCA>ACA	p.A1200T	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1200	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						ATACTGTCTGCGTGCTTCTTC	0.547000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling			
MYH3	4621	broad.mit.edu	37	17	10550594	10550594	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:10550594A>C	uc002gmq.1	-	9	880	c.803T>G	c.(802-804)CTT>CGT	p.L268R		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	268	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TTTTTCCAGAAGATCTGGAAC	0.428000												
DNAH9	1770	broad.mit.edu	37	17	11711210	11711210	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:11711210A>G	uc002gne.2	+	44	8650	c.8582A>G	c.(8581-8583)AAG>AGG	p.K2861R	DNAH9_uc010coo.2_Missense_Mutation_p.K2155R	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2861	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAGGACTTCAAGGTAAAAGGT	0.567000												
CORO6	84940	broad.mit.edu	37	17	27946705	27946705	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:27946705G>A	uc002hel.2	-	2	287	c.285C>T	c.(283-285)AAC>AAT	p.N95N	CORO6_uc002hem.2_5'Flank|CORO6_uc002hen.2_5'Flank	NM_032854	NP_116243	Q6QEF8	CORO6_HUMAN	coronin 6	95	WD 1.				actin cytoskeleton organization	actin cytoskeleton	actin filament binding				0						TGGCGATAACGTTGTCATTGT	0.582000												
TNS4	84951	broad.mit.edu	37	17	38634897	38634897	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:38634897C>T	uc010cxb.2	-	11	2078	c.1914G>A	c.(1912-1914)GTG>GTA	p.V638V	TNS4_uc002huu.3_Silent_p.V51V	NM_032865	NP_116254	Q8IZW8	TENS4_HUMAN	tensin 4 precursor	638	Phosphatase tensin-type.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			GCCGGAAAAACACCCTAGGAG	0.587000												
KRT33B	3884	broad.mit.edu	37	17	39521764	39521764	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:39521764G>A	uc002hwl.2	-	4	675	c.630C>T	c.(628-630)AAC>AAT	p.N210N		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	210	Linker 12.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				CCACCTCCACGTTGAGGCGGT	0.522000												
PHOSPHO1	162466	broad.mit.edu	37	17	47302153	47302153	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:47302153G>A	uc010wlv.1	-	3	625	c.259C>T	c.(259-261)CGG>TGG	p.R87W	PHOSPHO1_uc002ios.2_Missense_Mutation_p.R112W	NM_178500	NP_848595	Q8TCT1	PHOP1_HUMAN	phosphatase, orphan 1 isoform 2	87					regulation of bone mineralization		metal ion binding|phosphoethanolamine/phosphocholine phosphatase activity				0			Epithelial(5;8.1e-06)|all cancers(6;7.71e-05)		Choline(DB00122)	CTCAGGTCCCGCGGCCGCACG	0.637000												
BZRAP1	9256	broad.mit.edu	37	17	56388310	56388310	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:56388310G>T	uc002ivx.3	-	19	4217	c.3346C>A	c.(3346-3348)CTC>ATC	p.L1116I	BZRAP1_uc010dcs.2_Missense_Mutation_p.L1056I|BZRAP1_uc010wnt.1_Missense_Mutation_p.L1116I	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1116	Pro-rich.					mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGGTGCTGGAGAGGAGAGCTG	0.672000												
LRRC37A3	374819	broad.mit.edu	37	17	62856576	62856576	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:62856576C>T	uc002jey.2	-	11	4219	c.3688G>A	c.(3688-3690)GCC>ACC	p.A1230T	LRRC37A3_uc010wqg.1_Missense_Mutation_p.A348T|LRRC37A3_uc002jex.1_Missense_Mutation_p.A207T|LRRC37A3_uc010wqf.1_Missense_Mutation_p.A268T|LRRC37A3_uc010dek.1_Missense_Mutation_p.A236T	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1230	Extracellular (Potential).					integral to membrane					0						GTGTAGACGGCGTTTCCCGCT	0.567000												
GPS1	2873	broad.mit.edu	37	17	80011241	80011241	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr17:80011241T>C	uc002kdl.1	+	2	170	c.125T>C	c.(124-126)CTG>CCG	p.L42P	RFNG_uc002kdh.2_5'Flank|RFNG_uc002kdj.2_5'Flank|GPS1_uc002kdk.1_Missense_Mutation_p.L82P|GPS1_uc010dij.1_Missense_Mutation_p.L82P|GPS1_uc002kdm.1_Missense_Mutation_p.L26P|GPS1_uc002kdn.1_Missense_Mutation_p.L42P|GPS1_uc002kdo.1_Missense_Mutation_p.L42P|GPS1_uc010wvh.1_Missense_Mutation_p.L34P	NM_004127	NP_004118	Q13098	CSN1_HUMAN	G protein pathway suppressor 1 isoform 2	42					cell cycle|cullin deneddylation|inactivation of MAPK activity|JNK cascade	cytoplasm|signalosome	GTPase inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			AACCCCAGCCTGGTACGGAGC	0.637000												
C18orf1	753	broad.mit.edu	37	18	13645159	13645159	+	Missense_Mutation	SNP	A	A	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr18:13645159A>T	uc002ksa.2	+	7	1092	c.424A>T	c.(424-426)ACA>TCA	p.T142S	C18orf1_uc002ksb.2_Missense_Mutation_p.T124S|C18orf1_uc002kse.2_Missense_Mutation_p.T105S|C18orf1_uc002ksf.2_Missense_Mutation_p.T87S|C18orf1_uc002ksg.1_Missense_Mutation_p.T65S|C18orf1_uc002ksh.1_Missense_Mutation_p.T84S|C18orf1_uc002ksi.1_Missense_Mutation_p.T66S	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	142	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		GGACAGGTTCACAGCGCCGTC	0.547000												
ST8SIA5	29906	broad.mit.edu	37	18	44260338	44260338	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr18:44260338G>A	uc002lcj.1	-	7	1366	c.798C>T	c.(796-798)GAC>GAT	p.D266D	ST8SIA5_uc002lci.1_Silent_p.D113D|ST8SIA5_uc010xcy.1_Silent_p.D302D|ST8SIA5_uc010xcz.1_Silent_p.D235D	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	266	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						ATTCGAAGTCGTCCAGCACGT	0.612000												
POLI	11201	broad.mit.edu	37	18	51813737	51813737	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr18:51813737G>A	uc002lfj.3	+	8	1222	c.1154G>A	c.(1153-1155)CGT>CAT	p.R385H	POLI_uc010xds.1_Missense_Mutation_p.R306H|POLI_uc002lfk.3_Missense_Mutation_p.R282H|POLI_uc010dpg.2_5'UTR	NM_007195	NP_009126	Q9UNA4	POLI_HUMAN	DNA polymerase iota	385	DNA binding.				DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			ovary(2)|kidney(1)	3				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		CGTGAGAGTCGTCAGTGCCCT	0.403000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage				
JSRP1	126306	broad.mit.edu	37	19	2254273	2254273	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:2254273C>T	uc002lvi.1	-	3	210	c.175G>A	c.(175-177)GTG>ATG	p.V59M	JSRP1_uc002lvj.1_Missense_Mutation_p.V59M	NM_144616	NP_653217	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1	59	Mediates interaction with CACNA1S (By similarity).					sarcoplasmic reticulum membrane				pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGTGTCCACACTGGGGCCT	0.592000											OREG0025137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
CREB3L3	84699	broad.mit.edu	37	19	4171144	4171144	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:4171144A>C	uc002lzl.2	+	8	1063	c.947A>C	c.(946-948)AAG>ACG	p.K316T	CREB3L3_uc002lzm.2_Missense_Mutation_p.K306T|CREB3L3_uc010xib.1_Missense_Mutation_p.K305T|CREB3L3_uc010xic.1_Missense_Mutation_p.Q271H	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	316	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCACCAGCAAGTCAGCCCAG	0.612000												
OR2Z1	284383	broad.mit.edu	37	19	8841411	8841411	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:8841411G>A	uc010xkg.1	+	1	21	c.21G>A	c.(19-21)TCG>TCA	p.S7S		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						TGAATCAGTCGGTGGCCTCAG	0.468000												
MUC16	94025	broad.mit.edu	37	19	9072734	9072734	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:9072734C>A	uc002mkp.2	-	3	14916	c.14712G>T	c.(14710-14712)CAG>CAT	p.Q4904H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4906	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGTGATCTCCTGGGAGATGC	0.483000												
RHPN2	85415	broad.mit.edu	37	19	33486967	33486967	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:33486967T>G	uc002nuf.2	-	11	1451	c.1385A>C	c.(1384-1386)GAC>GCC	p.D462A	RHPN2_uc010xro.1_Missense_Mutation_p.D311A|RHPN2_uc002nue.2_Missense_Mutation_p.D192A	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	462					signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					GTTCAGCAGGTCATCCTCCTC	0.617000												
CHST8	64377	broad.mit.edu	37	19	34263466	34263466	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:34263466G>A	uc002nus.3	+	5	1278	c.773G>A	c.(772-774)CGC>CAC	p.R258H	CHST8_uc002nut.3_Missense_Mutation_p.R258H|CHST8_uc002nuu.2_Missense_Mutation_p.R258H	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	258	PAPS (By similarity).|Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					CTCTTTGTCCGCGAGCCCTTC	0.607000												
ZNF540	163255	broad.mit.edu	37	19	38102725	38102725	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:38102725G>A	uc002ogq.2	+	5	876	c.544G>A	c.(544-546)GAT>AAT	p.D182N	ZNF540_uc002ogu.2_Missense_Mutation_p.D182N|ZNF540_uc010efq.2_Missense_Mutation_p.D150N	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGGGAAAATAGATTCTGATGT	0.353000												
CATSPERG	57828	broad.mit.edu	37	19	38852366	38852366	+	Silent	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:38852366A>G	uc002oih.3	+	17	2046	c.1959A>G	c.(1957-1959)AGA>AGG	p.R653R	CATSPERG_uc002oig.3_Silent_p.R613R|CATSPERG_uc002oif.3_Silent_p.R293R|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	653	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						GTCCGCAGAGATACACGCGCC	0.667000												
RYR1	6261	broad.mit.edu	37	19	38956792	38956792	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:38956792C>T	uc002oit.2	+	24	3062	c.2932C>T	c.(2932-2934)CCG>TCG	p.P978S	RYR1_uc002oiu.2_Missense_Mutation_p.P978S	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	978	2.|Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCGGCTGACGCCGGCGCAGAC	0.652000												
ARHGEF1	9138	broad.mit.edu	37	19	42407468	42407468	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:42407468G>A	uc002orx.2	+	19	1859	c.1750G>A	c.(1750-1752)GAA>AAA	p.E584K	ARHGEF1_uc002ory.2_Missense_Mutation_p.E551K|ARHGEF1_uc002orz.2_Missense_Mutation_p.E422K|ARHGEF1_uc002osa.2_Missense_Mutation_p.E599K|ARHGEF1_uc002osb.2_Missense_Mutation_p.E566K|ARHGEF1_uc002osc.2_Missense_Mutation_p.E338K|ARHGEF1_uc002osd.2_Missense_Mutation_p.E243K|ARHGEF1_uc002ose.2_Missense_Mutation_p.E28K	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	584	DH.				cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		AGAGCCCACAGAACGGGAGAA	0.592000												
BCAM	4059	broad.mit.edu	37	19	45322614	45322614	+	Silent	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:45322614A>G	uc002ozu.2	+	12	1529	c.1485A>G	c.(1483-1485)CCA>CCG	p.P495P	BCAM_uc002ozt.1_Silent_p.P495P	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	495	Extracellular (Potential).|Ig-like C2-type 3.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				CCGCAGAGCCAATCCCCGGAC	0.657000												
KCNC3	3748	broad.mit.edu	37	19	50827318	50827318	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:50827318A>G	uc002pru.1	-	2	1187	c.892T>C	c.(892-894)TTC>CTC	p.F298L	KCNC3_uc002prt.1_5'UTR	NM_004977	NP_004968	Q14003	KCNC3_HUMAN	Shaw-related voltage-gated potassium channel	298	Helical; Name=Segment S1; (Potential).				cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		AGGATGAAGAAGAGGGAGGCG	0.577000												
SIGLEC10	89790	broad.mit.edu	37	19	51914402	51914402	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:51914402C>T	uc002pwo.2	-	11	2661	c.2045G>A	c.(2044-2046)CGG>CAG	p.R682Q	SIGLEC10_uc002pwp.2_Missense_Mutation_p.R624Q|SIGLEC10_uc002pwq.2_Missense_Mutation_p.R529Q|SIGLEC10_uc002pwr.2_Missense_Mutation_p.R587Q|SIGLEC10_uc010ycy.1_Missense_Mutation_p.R497Q|SIGLEC10_uc010ycz.1_Missense_Mutation_p.R539Q|SIGLEC10_uc010eow.2_Missense_Mutation_p.R399Q	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	682	Cytoplasmic (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		CTTGGGCATCCGGGCCTCAGG	0.572000												
BIRC8	112401	broad.mit.edu	37	19	53793336	53793336	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:53793336T>G	uc002qbk.2	-	1	1540	c.292A>C	c.(292-294)ACA>CCA	p.T98P		NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8	98					apoptosis		zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		AGTGATGGTGTTTTCTTGGTA	0.368000												
ZSCAN5B	342933	broad.mit.edu	37	19	56702324	56702324	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:56702324G>A	uc010ygh.1	-	3	621	c.621C>T	c.(619-621)GAC>GAT	p.D207D		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	207					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CACCTGTTACGTCAATACTCT	0.507000												
ZNF667	63934	broad.mit.edu	37	19	56953232	56953232	+	Silent	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:56953232T>G	uc002qnd.2	-	5	1294	c.1132A>C	c.(1132-1134)AGA>CGA	p.R378R	ZNF667_uc010etl.2_Silent_p.R160R|ZNF667_uc002qne.2_Silent_p.R378R|ZNF667_uc010etm.2_Silent_p.R321R	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	378	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TTATGAATTCTTAGATGCAGA	0.378000												
ZNF135	7694	broad.mit.edu	37	19	58578513	58578513	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:58578513A>G	uc010yhq.1	+	5	793	c.697A>G	c.(697-699)AAG>GAG	p.K233E	ZNF135_uc002qre.2_Missense_Mutation_p.K221E|ZNF135_uc002qrd.1_Missense_Mutation_p.K179E|ZNF135_uc002qrf.2_Missense_Mutation_p.K179E|ZNF135_uc002qrg.2_Missense_Mutation_p.K191E|ZNF135_uc010yhr.1_Missense_Mutation_p.K42E	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	233					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		GGAATGCGGAAAGGCCTTTAG	0.473000												
C2orf71	388939	broad.mit.edu	37	2	29295113	29295113	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:29295113T>C	uc002rmt.1	-	1	2015	c.2015A>G	c.(2014-2016)AAG>AGG	p.K672R		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	672					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						ACTGAAGTTCTTGGTGAGGGA	0.547000												
SLC8A1	6546	broad.mit.edu	37	2	40342635	40342635	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:40342635C>T	uc002rrx.2	-	10	2704	c.2680G>A	c.(2680-2682)GCA>ACA	p.A894T	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Missense_Mutation_p.A889T|SLC8A1_uc002rrz.2_Missense_Mutation_p.A881T|SLC8A1_uc002rsa.2_Missense_Mutation_p.A858T|SLC8A1_uc002rsd.3_Missense_Mutation_p.A858T	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	894	Helical; (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CCATTGGCTGCGTGGTAGATG	0.542000												
EPAS1	2034	broad.mit.edu	37	2	46607812	46607812	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:46607812G>T	uc002ruv.2	+	12	2489	c.2001G>T	c.(1999-2001)TTG>TTT	p.L667F	EPAS1_uc002ruw.2_Missense_Mutation_p.L133F	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	667					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			CAGCGCCGTTGGGGCCCCCTG	0.597000												
PCBP1	5093	broad.mit.edu	37	2	70315843	70315843	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:70315843C>T	uc002sgf.2	+	1	1259	c.968C>T	c.(967-969)TCT>TTT	p.S323F	ASPRV1_uc002sga.2_5'Flank|uc002sgb.1_5'Flank|uc002sgd.2_5'Flank|uc002sge.1_5'Flank	NM_006196	NP_006187	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	323	KH 3.				nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding				0						GAAGGCTCCTCTGGTAGGCAG	0.537000												
CNGA3	1261	broad.mit.edu	37	2	99013602	99013602	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:99013602A>C	uc002syt.2	+	8	2386	c.1969A>C	c.(1969-1971)AAG>CAG	p.K657Q	CNGA3_uc002syu.2_Missense_Mutation_p.K639Q|CNGA3_uc010fij.2_Missense_Mutation_p.K661Q	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	657					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						CACCCAGATGAAGATGAAGCA	0.587000												
TFCP2L1	29842	broad.mit.edu	37	2	122004466	122004466	+	Silent	SNP	C	C	T	rs148066295	byFrequency	TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:122004466C>T	uc002tmx.2	-	6	678	c.585G>A	c.(583-585)ACG>ACA	p.T195T	TFCP2L1_uc010flr.2_Silent_p.T195T	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	195					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					TCTGCTTAAACGTGTCAATCT	0.572000												
CNTNAP5	129684	broad.mit.edu	37	2	125367442	125367442	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:125367442C>T	uc002tno.2	+	12	2182	c.1818C>T	c.(1816-1818)ATC>ATT	p.I606I	CNTNAP5_uc010flu.2_Silent_p.I607I	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	606	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCTTCTACATCGACTCAGATG	0.527000												
NCKAP5	344148	broad.mit.edu	37	2	133540568	133540568	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:133540568T>G	uc002ttp.2	-	14	4190	c.3816A>C	c.(3814-3816)AAA>AAC	p.K1272N	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1272							protein binding				0						GGCTGCGGGCTTTGGCGCCAT	0.527000												
RPRM	56475	broad.mit.edu	37	2	154335019	154335019	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:154335019C>T	uc002tyq.1	-	1	304	c.61G>A	c.(61-63)GAG>AAG	p.E21K		NM_019845	NP_062819	Q9NS64	RPRM_HUMAN	reprimo, TP53 dependant G2 arrest mediator	21					cell cycle arrest	cytoplasm|integral to membrane	protein binding				0						TCCAGCGCCTCGCTGCTGTTG	0.711000												
HOXD12	3238	broad.mit.edu	37	2	176964778	176964778	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:176964778C>T	uc010zev.1	+	1	249	c.249C>T	c.(247-249)CTC>CTT	p.L83L	HOXD12_uc010zew.1_Silent_p.L83L	NM_021193	NP_067016	P35452	HXD12_HUMAN	homeobox D12	83				GPLG -> ASR (in Ref. 1; AAF79044).		nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		CCGGGCCTCTCGGCCTGCAGC	0.741000												
TTN	7273	broad.mit.edu	37	2	179400781	179400781	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:179400781C>T	uc010zfg.1	-	306	93213	c.92989G>A	c.(92989-92991)GCC>ACC	p.A30997T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.A24692T|TTN_uc010zfi.1_Missense_Mutation_p.A24625T|TTN_uc010zfj.1_Missense_Mutation_p.A24500T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31924							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAAACTGTGGCATCATCATCT	0.408000												
TTN	7273	broad.mit.edu	37	2	179448559	179448559	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:179448559C>T	uc010zfg.1	-	261	57870	c.57646G>A	c.(57646-57648)GAT>AAT	p.D19216N	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D12911N|TTN_uc010zfi.1_Missense_Mutation_p.D12844N|TTN_uc010zfj.1_Missense_Mutation_p.D12719N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20143							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCCTCCATCATGCTTTGGA	0.453000												
TTN	7273	broad.mit.edu	37	2	179482725	179482725	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:179482725C>T	uc010zfg.1	-	202	39873	c.39649G>A	c.(39649-39651)GAT>AAT	p.D13217N	TTN_uc010zfh.1_Missense_Mutation_p.D6912N|TTN_uc010zfi.1_Missense_Mutation_p.D6845N|TTN_uc010zfj.1_Missense_Mutation_p.D6720N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14144							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCACCTCCATCATACTCTGGT	0.463000												
TTN	7273	broad.mit.edu	37	2	179585215	179585215	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:179585215A>C	uc010zfg.1	-	77	19766	c.19542T>G	c.(19540-19542)AGT>AGG	p.S6514R	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S3175R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7441							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGATATGAAGACTTGTATCAA	0.398000												
TTN	7273	broad.mit.edu	37	2	179647007	179647007	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:179647007T>A	uc010zfg.1	-	20	3536	c.3312A>T	c.(3310-3312)CAA>CAT	p.Q1104H	TTN_uc010zfh.1_Missense_Mutation_p.Q1058H|TTN_uc010zfi.1_Missense_Mutation_p.Q1058H|TTN_uc010zfj.1_Missense_Mutation_p.Q1058H|TTN_uc002unb.2_Missense_Mutation_p.Q1104H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1104							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCCGCCAACTTGGCATCCAA	0.488000												
ALS2CR8	79800	broad.mit.edu	37	2	203839206	203839206	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:203839206T>A	uc002uzo.2	+	12	1761	c.1481T>A	c.(1480-1482)ATT>AAT	p.I494N	ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Missense_Mutation_p.I418N|ALS2CR8_uc010zib.1_Missense_Mutation_p.I418N|ALS2CR8_uc010zic.1_Missense_Mutation_p.I406N|ALS2CR8_uc002uzp.2_Missense_Mutation_p.I494N	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	494										large_intestine(1)|ovary(1)	2						AACTCAGAGATTATTCCAGCA	0.318000												
ZDBF2	57683	broad.mit.edu	37	2	207171081	207171081	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:207171081T>C	uc002vbp.2	+	5	2079	c.1829T>C	c.(1828-1830)GTC>GCC	p.V610A		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	610							nucleic acid binding|zinc ion binding			ovary(3)	3						GGTAGACAAGTCCACCTAAAA	0.418000												
CRYGA	1418	broad.mit.edu	37	2	209027988	209027988	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:209027988G>A	uc002vcq.3	-	2	209	c.192C>T	c.(190-192)CCC>CCT	p.P64P		NM_014617	NP_055432	P11844	CRGA_HUMAN	crystallin, gamma A	64	Beta/gamma crystallin 'Greek key' 2.				visual perception		structural constituent of eye lens				0				Epithelial(149;0.067)|LUSC - Lung squamous cell carcinoma(261;0.0708)|Lung(261;0.135)		GCTGATAGTCGGGGTACTTGC	0.547000												
ERBB4	2066	broad.mit.edu	37	2	212251872	212251872	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:212251872G>T	uc002veg.1	-	27	3285	c.3187C>A	c.(3187-3189)CAG>AAG	p.Q1063K	ERBB4_uc002veh.1_Missense_Mutation_p.Q1047K|ERBB4_uc010zji.1_Missense_Mutation_p.Q1053K|ERBB4_uc010zjj.1_Missense_Mutation_p.Q1037K	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1063	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TATACAAACTGGTTCTGTTAA	0.428000										TSP Lung(8;0.080)		
ABCA12	26154	broad.mit.edu	37	2	215812212	215812212	+	Silent	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:215812212A>G	uc002vew.2	-	48	7393	c.7173T>C	c.(7171-7173)AGT>AGC	p.S2391S	ABCA12_uc002vev.2_Silent_p.S2073S|ABCA12_uc010zjn.1_Silent_p.S1318S	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2391	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTGTGCCATAACTGCACATAG	0.433000												
ZNF142	7701	broad.mit.edu	37	2	219508077	219508077	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:219508077G>A	uc002vin.2	-	8	3598	c.3162C>T	c.(3160-3162)GGC>GGT	p.G1054G	ZNF142_uc002vil.2_Silent_p.G1015G|ZNF142_uc010fvt.2_Silent_p.G891G|ZNF142_uc002vim.2_Silent_p.G891G	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1054					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TTCCTCCCCCGCCACGTCCCC	0.602000												
GLB1L	79411	broad.mit.edu	37	2	220101991	220101991	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr2:220101991T>C	uc002vkm.2	-	17	2007	c.1768A>G	c.(1768-1770)AGA>GGA	p.R590G	GLB1L_uc002vkk.2_Missense_Mutation_p.R347G|GLB1L_uc010zkx.1_Missense_Mutation_p.R500G|GLB1L_uc002vkn.2_Missense_Mutation_p.R590G	NM_024506	NP_078782	Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like precursor	590					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds				0		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCAGGAATCTTGGCACGTAG	0.502000												
BMP2	650	broad.mit.edu	37	20	6759323	6759323	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr20:6759323A>G	uc002wmu.1	+	3	1563	c.778A>G	c.(778-780)ATA>GTA	p.I260V		NM_001200	NP_001191	P12643	BMP2_HUMAN	bone morphogenetic protein 2 preproprotein	260					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			ovary(1)|breast(1)	2					Simvastatin(DB00641)	CTGGTCACAGATAAGGCCATT	0.473000												
NCOA6	23054	broad.mit.edu	37	20	33345129	33345129	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr20:33345129C>T	uc002xav.2	-	8	3993	c.1422G>A	c.(1420-1422)CCG>CCA	p.P474P	NCOA6_uc002xaw.2_Silent_p.P474P|NCOA6_uc010gew.1_Silent_p.P431P	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	474	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						GATTCCGACCCGGAGAGCTGA	0.542000												
PHACTR3	116154	broad.mit.edu	37	20	58411587	58411587	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr20:58411587A>C	uc002yau.2	+	9	1823	c.1356A>C	c.(1354-1356)GAA>GAC	p.E452D	PHACTR3_uc002yat.2_Missense_Mutation_p.E449D|PHACTR3_uc010zzw.1_Missense_Mutation_p.E411D|PHACTR3_uc002yav.2_Missense_Mutation_p.E411D|PHACTR3_uc002yaw.2_Missense_Mutation_p.E411D|PHACTR3_uc002yax.2_Missense_Mutation_p.E341D|PHACTR3_uc002yay.2_Missense_Mutation_p.E21D	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	452	RPEL 3.|Required for PP1CA binding and inhibition of PP1 activity.|Potential.					nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CTGCCGTGGAAGAGCTGGAGA	0.488000												
BHLHE23	128408	broad.mit.edu	37	20	61637712	61637712	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr20:61637712G>T	uc002yeb.2	-	1	676	c.367C>A	c.(367-369)CTG>ATG	p.L123M		NM_080606	NP_542173	Q8NDY6	BHE23_HUMAN	basic helix-loop-helix domain containing, class	123	Helix-loop-helix motif.				transcription, DNA-dependent	nucleus	DNA binding				0						ACGGCTCGCAGCCCGTCCAGC	0.418000												
SFRS15	57466	broad.mit.edu	37	21	33043943	33043943	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr21:33043943C>T	uc002ypd.2	-	20	3639	c.3213G>A	c.(3211-3213)GAG>GAA	p.E1071E	SFRS15_uc002ype.2_Silent_p.E1049E|SFRS15_uc010glu.2_Silent_p.E1056E	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	1071						nucleus	nucleotide binding|RNA binding				0						CTTCTTCCTTCTCTCTACGAG	0.502000												
SFRS15	57466	broad.mit.edu	37	21	33044004	33044004	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr21:33044004C>G	uc002ypd.2	-	20	3578	c.3152G>C	c.(3151-3153)AGA>ACA	p.R1051T	SFRS15_uc002ype.2_Missense_Mutation_p.R1029T|SFRS15_uc010glu.2_Missense_Mutation_p.R1036T	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	1051						nucleus	nucleotide binding|RNA binding				0						ACTAGAGCGTCTATTTCTCTC	0.498000												
SFRS15	57466	broad.mit.edu	37	21	33044064	33044064	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr21:33044064C>T	uc002ypd.2	-	20	3518	c.3092G>A	c.(3091-3093)AGA>AAA	p.R1031K	SFRS15_uc002ype.2_Missense_Mutation_p.R1009K|SFRS15_uc010glu.2_Missense_Mutation_p.R1016K	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	1031						nucleus	nucleotide binding|RNA binding				0						TCCCCACTCTCTCCTGTCACG	0.483000												
SFRS15	57466	broad.mit.edu	37	21	33044066	33044066	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr21:33044066C>T	uc002ypd.2	-	20	3516	c.3090G>A	c.(3088-3090)AGG>AGA	p.R1030R	SFRS15_uc002ype.2_Silent_p.R1008R|SFRS15_uc010glu.2_Silent_p.R1015R	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	1030						nucleus	nucleotide binding|RNA binding				0						CCCACTCTCTCCTGTCACGGT	0.478000												
SFRS15	57466	broad.mit.edu	37	21	33076187	33076187	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr21:33076187C>A	uc002ypd.2	-	4	638	c.212G>T	c.(211-213)CGA>CTA	p.R71L	SFRS15_uc002ype.2_Missense_Mutation_p.R71L|SFRS15_uc010glu.2_Missense_Mutation_p.R56L|SFRS15_uc002ypf.1_5'Flank|SFRS15_uc002ypg.2_Missense_Mutation_p.R71L	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	71	CID.					nucleus	nucleotide binding|RNA binding				0						ACGAGACTGTCGCACAATTGA	0.358000												
ERG	2078	broad.mit.edu	37	21	39755334	39755334	+	Silent	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr21:39755334A>C	uc010gnw.2	-	12	1747	c.1452T>G	c.(1450-1452)ACT>ACG	p.T484T	ERG_uc002yxa.2_Silent_p.T477T|ERG_uc011aek.1_Silent_p.T385T|ERG_uc010gnv.2_Silent_p.T361T|ERG_uc010gnx.2_Silent_p.T460T|ERG_uc011ael.1_Silent_p.T484T|ERG_uc002yxb.2_Silent_p.T460T	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	484					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				TTTAGTAGTAAGTGCCCAGAT	0.502000												
LRRC3	81543	broad.mit.edu	37	21	45876639	45876639	+	Missense_Mutation	SNP	C	C	T	rs142928276		TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr21:45876639C>T	uc002zfa.2	+	2	405	c.112C>T	c.(112-114)CGG>TGG	p.R38W		NM_030891	NP_112153	Q9BY71	LRRC3_HUMAN	leucine-rich repeat-containing 3 precursor	38	LRRNT.					integral to membrane	protein binding				0		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		ACAGCCCTGCCGGTGCCCTGA	0.692000												
ZNF70	7621	broad.mit.edu	37	22	24086106	24086106	+	Missense_Mutation	SNP	C	C	T	rs143352353		TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr22:24086106C>T	uc002zxs.2	-	2	1683	c.1222G>A	c.(1222-1224)GAG>AAG	p.E408K	ZNF70_uc002zxr.1_5'Flank	NM_021916	NP_068735	Q9UC06	ZNF70_HUMAN	zinc finger protein 70	408	C2H2-type 10.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						TTATAGTGCTCAATGAGGGCT	0.577000												
MIOX	55586	broad.mit.edu	37	22	50926149	50926149	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr22:50926149C>G	uc003bll.1	+	3	269	c.155C>G	c.(154-156)ACA>AGA	p.T52R	MIOX_uc003blm.1_Missense_Mutation_p.T52R|MIOX_uc003bln.1_Missense_Mutation_p.T52R	NM_017584	NP_060054	Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	52					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ACGCACCAGACAGTGGACTTC	0.667000												
EFHB	151651	broad.mit.edu	37	3	19974753	19974753	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:19974753T>C	uc003cbl.3	-	1	954	c.758A>G	c.(757-759)AAG>AGG	p.K253R	EFHB_uc003cbm.2_Missense_Mutation_p.K123R	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	253					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						ATCAAAAAACTTCCCAGAGTA	0.428000												
SCN5A	6331	broad.mit.edu	37	3	38648286	38648286	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:38648286G>A	uc003cio.2	-	9	1208	c.1014C>T	c.(1012-1014)GGC>GGT	p.G338G	SCN5A_uc003cin.2_Silent_p.G338G|SCN5A_uc003cil.3_Silent_p.G338G|SCN5A_uc010hhi.2_Silent_p.G338G|SCN5A_uc010hhk.2_Silent_p.G338G|SCN5A_uc011ayr.1_Silent_p.G338G|SCN5A_uc010hhj.1_5'Flank	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	338					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GGCACCGGTAGCCCTCCGGAC	0.607000												
SCN10A	6336	broad.mit.edu	37	3	38755486	38755486	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:38755486C>T	uc003ciq.2	-	21	3767	c.3767G>A	c.(3766-3768)CGG>CAG	p.R1256Q		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1256	III.|Helical; Voltage-sensor; Name=S4 of repeat III; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCGCAGTGGCCGCAGAGCGCG	0.423000												
SCN11A	11280	broad.mit.edu	37	3	38888666	38888666	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:38888666T>G	uc011ays.1	-	26	5094	c.4895A>C	c.(4894-4896)AAG>ACG	p.K1632T		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1632					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TGGGTCAAACTTTTCCCACAC	0.398000												
NCKIPSD	51517	broad.mit.edu	37	3	48717103	48717103	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:48717103C>T	uc003cun.2	-	8	1488	c.1394G>A	c.(1393-1395)GGC>GAC	p.G465D	NCKIPSD_uc003cum.2_Missense_Mutation_p.G458D	NM_016453	NP_057537	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain isoform	465	Leu-rich.				cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCACATGGCGCCAAAGCACTT	0.607000												
GMPPB	29925	broad.mit.edu	37	3	49760467	49760467	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:49760467C>T	uc003cxk.1	-	4	565	c.340G>A	c.(340-342)GAT>AAT	p.D114N	GMPPB_uc003cxl.1_Missense_Mutation_p.D114N	NM_021971	NP_068806	Q9Y5P6	GMPPB_HUMAN	GDP-mannose pyrophosphorylase B isoform 2	114					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AAGGGGAAATCGCAGATCACG	0.607000												
CACNA2D3	55799	broad.mit.edu	37	3	55038828	55038828	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:55038828A>C	uc003dhf.2	+	32	2777	c.2729A>C	c.(2728-2730)AAC>ACC	p.N910T	CACNA2D3_uc003dhg.1_Missense_Mutation_p.N816T|CACNA2D3_uc003dhh.1_RNA	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	910	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGTAGAGCCAACAAGGAAAGC	0.463000												
EPHA3	2042	broad.mit.edu	37	3	89499325	89499325	+	Splice_Site	SNP	A	A	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:89499325A>T	uc003dqy.2	+	15	2722	c.2497_splice	c.e15-2	p.V833_splice	EPHA3_uc010hon.1_Splice_Site	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor							extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CTTCTCACACAGGTAATTAAA	0.478000										TSP Lung(6;0.00050)		
OR5AC2	81050	broad.mit.edu	37	3	97806056	97806056	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:97806056T>C	uc011bgs.1	+	1	40	c.40T>C	c.(40-42)TTT>CTT	p.F14L		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGTGACAGAGTTTGTTCTCAC	0.418000												
COL8A1	1295	broad.mit.edu	37	3	99513455	99513455	+	Missense_Mutation	SNP	G	G	T	rs147906655	byFrequency	TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:99513455G>T	uc003dtg.1	+	5	955	c.710G>T	c.(709-711)CGG>CTG	p.R237L	COL8A1_uc003dth.1_Missense_Mutation_p.R237L|COL8A1_uc003dti.1_Missense_Mutation_p.R238L	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	237	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						CAAGGCCTTCGGGGTCCTAAA	0.632000												
PARP9	83666	broad.mit.edu	37	3	122274887	122274887	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:122274887C>A	uc010hri.2	-	4	381	c.236G>T	c.(235-237)CGT>CTT	p.R79L	PARP9_uc003eff.3_Missense_Mutation_p.R44L|PARP9_uc011bjs.1_Missense_Mutation_p.R44L|PARP9_uc003efg.2_Intron|PARP9_uc003efi.2_Missense_Mutation_p.R44L|PARP9_uc003efh.2_Missense_Mutation_p.R79L|PARP9_uc003efj.2_Missense_Mutation_p.R44L	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	79					cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		ACACAGCTGACGCTCATTATT	0.403000												
C3orf27	23434	broad.mit.edu	37	3	128292250	128292250	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:128292250C>A	uc003ekq.2	-	3	1290	c.323G>T	c.(322-324)GGG>GTG	p.G108V		NM_007354	NP_031380	O15544	GR6_HUMAN	putative GR6 protein	108											0				GBM - Glioblastoma multiforme(114;0.176)		GAGGAAAGGCCCACAGTGGCA	0.567000												
RBP2	5948	broad.mit.edu	37	3	139173592	139173592	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:139173592A>C	uc003eth.2	-	3	384	c.333T>G	c.(331-333)ATT>ATG	p.I111M		NM_004164	NP_004155	P50120	RET2_HUMAN	retinol binding protein 2, cellular	111					epidermis development|retinoid metabolic process|steroid metabolic process|vitamin A metabolic process	cytosol	retinal binding|retinol binding|transporter activity			skin(1)	1					Vitamin A(DB00162)	TGTCCCCCTCAATCCACTGCT	0.532000												
ZBBX	79740	broad.mit.edu	37	3	167023666	167023666	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:167023666T>C	uc003fep.2	-	17	1813	c.1490A>G	c.(1489-1491)GAG>GGG	p.E497G	ZBBX_uc011bpc.1_Missense_Mutation_p.E497G|ZBBX_uc003feq.2_Missense_Mutation_p.E468G	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	497						intracellular	zinc ion binding			ovary(2)	2						GGTGCTTTCCTCAATTTTTTC	0.338000												
C3orf70	285382	broad.mit.edu	37	3	184801262	184801262	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:184801262G>T	uc003fpd.2	-	2	477	c.286C>A	c.(286-288)CAG>AAG	p.Q96K		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	96											0						ACTGAGATCTGAATGGTGTTT	0.502000												
SENP2	59343	broad.mit.edu	37	3	185324165	185324165	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:185324165G>A	uc003fpn.2	+	6	668	c.497G>A	c.(496-498)CGC>CAC	p.R166H	SENP2_uc011brv.1_Missense_Mutation_p.R156H|SENP2_uc011brw.1_5'UTR	NM_021627	NP_067640	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific protease 2	166					mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity				0	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			GGTGGCCGTCGCCATAGCAAA	0.423000												
UBXN7	26043	broad.mit.edu	37	3	196129884	196129884	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr3:196129884T>G	uc003fwm.3	-	3	303	c.228A>C	c.(226-228)GAA>GAC	p.E76D	UBXN7_uc003fwn.3_5'UTR|UBXN7_uc010iae.2_Intron|UBXN7_uc010iaf.2_Missense_Mutation_p.E76D	NM_015562	NP_056377	O94888	UBXN7_HUMAN	UBX domain containing 7	76							protein binding			ovary(2)|pancreas(1)	3						GGGCACGAACTTCTTCTCTAT	0.323000												
GABRB1	2560	broad.mit.edu	37	4	47427934	47427934	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr4:47427934G>A	uc003gxh.2	+	9	1698	c.1324G>A	c.(1324-1326)GAC>AAC	p.D442N	GABRB1_uc011bze.1_Missense_Mutation_p.D372N	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	442	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CAAGATCCCCGACTTGACTGA	0.557000												
KDR	3791	broad.mit.edu	37	4	55972029	55972029	+	Missense_Mutation	SNP	C	C	T	rs55716939	byFrequency	TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr4:55972029C>T	uc003has.2	-	12	1917	c.1615G>A	c.(1615-1617)GGA>AGA	p.G539R	KDR_uc003hat.1_Missense_Mutation_p.G539R|KDR_uc011bzx.1_Missense_Mutation_p.G539R	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	539	Ig-like C2-type 5.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	ACCCTCTCTCCTCTCCCGACT	0.473000			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)		
DMP1	1758	broad.mit.edu	37	4	88583780	88583780	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr4:88583780G>A	uc003hqv.2	+	6	954	c.850G>A	c.(850-852)GAC>AAC	p.D284N	DMP1_uc003hqw.2_Missense_Mutation_p.D268N	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	284					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CGAGCTTGATGACAACAACAC	0.488000												
SCLT1	132320	broad.mit.edu	37	4	129913355	129913355	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr4:129913355C>G	uc003igp.2	-	9	1159	c.653G>C	c.(652-654)AGT>ACT	p.S218T	SCLT1_uc003igo.2_5'UTR|SCLT1_uc003igq.2_Missense_Mutation_p.S218T|SCLT1_uc010iob.1_Intron	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	sodium channel associated protein 1	218	Potential.					centrosome				ovary(3)|lung(1)|central_nervous_system(1)	5						GATTATCACACTTTGTTCAGT	0.294000												
PCDH10	57575	broad.mit.edu	37	4	134073102	134073102	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr4:134073102G>A	uc003iha.2	+	1	2633	c.1807G>A	c.(1807-1809)GTG>ATG	p.V603M	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.V603M	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	603	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GCTCACCCGCGTGGCCGCCGT	0.692000												
DCHS2	54798	broad.mit.edu	37	4	155237128	155237128	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr4:155237128T>C	uc003inw.2	-	15	3667	c.3667A>G	c.(3667-3669)ACA>GCA	p.T1223A		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1223	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GGACAGGTTGTGGTTAGTAAG	0.383000												
LRAT	9227	broad.mit.edu	37	4	155665550	155665550	+	Silent	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr4:155665550C>T	uc003iom.1	+	1	399	c.72C>T	c.(70-72)CTC>CTT	p.L24L	uc003iol.2_Intron|LRAT_uc003ion.1_Silent_p.L24L	NM_004744	NP_004735	O95237	LRAT_HUMAN	lecithin retinol acyltransferase	24	Cytoplasmic (By similarity).				response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	ACTTCACGCTCTTTAGTTCGG	0.577000												
SLC12A7	10723	broad.mit.edu	37	5	1052500	1052500	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr5:1052500C>T	uc003jbu.2	-	24	3293	c.3227G>A	c.(3226-3228)CGG>CAG	p.R1076Q		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	1076	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GATCACCTCCCGGCCGCCACC	0.612000												
ADAMTS16	170690	broad.mit.edu	37	5	5187859	5187859	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr5:5187859G>A	uc003jdl.2	+	6	1123	c.985G>A	c.(985-987)GGA>AGA	p.G329R	ADAMTS16_uc003jdk.1_Missense_Mutation_p.G329R|ADAMTS16_uc003jdj.1_Missense_Mutation_p.G329R	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	329	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ATTCAAAGATGGAACAATAGG	0.388000												
RXFP3	51289	broad.mit.edu	37	5	33938145	33938145	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr5:33938145C>A	uc003jic.1	+	1	1657	c.1300C>A	c.(1300-1302)CCG>ACG	p.P434T		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	434	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						GCTGCAggccccggcgccgcc	0.567000												
GZMA	3001	broad.mit.edu	37	5	54405934	54405934	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr5:54405934G>A	uc003jpm.2	+	5	750	c.713G>A	c.(712-714)CGT>CAT	p.R238H		NM_006144	NP_006135	P12544	GRAA_HUMAN	granzyme A precursor	238	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				GGAGACCCTCGTGGGCCTGGT	0.448000												
IL31RA	133396	broad.mit.edu	37	5	55185823	55185823	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr5:55185823G>A	uc003jql.2	+	6	697	c.632G>A	c.(631-633)CGT>CAT	p.R211H	IL31RA_uc003jqk.2_Missense_Mutation_p.R211H|IL31RA_uc011cqj.1_Missense_Mutation_p.R69H|IL31RA_uc003jqm.2_Missense_Mutation_p.R179H|IL31RA_uc003jqn.2_Missense_Mutation_p.R211H|IL31RA_uc010iwa.1_Missense_Mutation_p.R179H|IL31RA_uc003jqo.2_Missense_Mutation_p.R69H	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	179	Extracellular (Potential).|Fibronectin type-III 2.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				GCTAAGAACCGTAAGGATAAA	0.448000												
CCDC125	202243	broad.mit.edu	37	5	68578671	68578671	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr5:68578671C>G	uc003jvv.1	-	11	1464	c.1421G>C	c.(1420-1422)AGT>ACT	p.S474T	CCDC125_uc003jvx.1_3'UTR|CCDC125_uc003jvy.1_RNA|CCDC125_uc003jvw.2_Missense_Mutation_p.S349T	NM_176816	NP_789786	Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	474						cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		AATGCAGACACTTGAATGTAT	0.363000												
CAMK4	814	broad.mit.edu	37	5	110712611	110712611	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr5:110712611A>C	uc011cvj.1	+	5	456	c.357A>C	c.(355-357)GAA>GAC	p.E119D	CAMK4_uc003kpf.2_Missense_Mutation_p.E119D|CAMK4_uc010jbv.2_Intron	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	119	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		TGGTCCTAGAACTCGTCACAG	0.343000												
FAM170A	340069	broad.mit.edu	37	5	118968544	118968544	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr5:118968544T>C	uc003ksm.2	+	2	382	c.172T>C	c.(172-174)TGC>CGC	p.C58R	FAM170A_uc003ksl.2_Missense_Mutation_p.C58R|FAM170A_uc003ksn.2_Missense_Mutation_p.C58R|FAM170A_uc003kso.2_Intron	NM_182761	NP_877438	A1A519	F170A_HUMAN	family with sequence similarity 170, member A	58						intracellular	zinc ion binding			skin(1)	1						CTCCGAATACTGCTCCTGCGT	0.552000												
LECT2	3950	broad.mit.edu	37	5	135286988	135286988	+	Silent	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr5:135286988A>G	uc003lbe.1	-	3	414	c.213T>C	c.(211-213)ACT>ACC	p.T71T	FBXL21_uc003lbc.2_RNA	NM_002302	NP_002293	O14960	LECT2_HUMAN	leukocyte cell-derived chemotaxin 2 precursor	71					chemotaxis|skeletal system development	cytoplasm|extracellular space				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CAATCATTCCAGTGAATGGTG	0.453000												
PCDHA1	56147	broad.mit.edu	37	5	140168189	140168189	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr5:140168189T>G	uc003lhb.2	+	1	2314	c.2314T>G	c.(2314-2316)TTC>GTC	p.F772V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.F772V	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	772	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCATGGCCTTCAGCCCAGG	0.532000												
PCDHGA9	56107	broad.mit.edu	37	5	140782734	140782734	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr5:140782734C>T	uc003lkh.1	+	1	215	c.215C>T	c.(214-216)ACG>ATG	p.T72M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.T72M	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	72	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGGTAGGACGCAGCTTTTC	0.622000												
RNF182	221687	broad.mit.edu	37	6	13977616	13977616	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr6:13977616T>G	uc003nbe.2	+	3	684	c.266T>G	c.(265-267)GTA>GGA	p.V89G	RNF182_uc003nbf.2_Missense_Mutation_p.V89G|RNF182_uc003nbg.2_Missense_Mutation_p.V89G	NM_152737	NP_689950	Q8N6D2	RN182_HUMAN	ring finger protein 182	89						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			AACATCCTTGTAAACTTGACT	0.532000												
HIST1H1C	3006	broad.mit.edu	37	6	26056613	26056613	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr6:26056613G>A	uc003nfw.2	-	1	87	c.44C>T	c.(43-45)GCG>GTG	p.A15V		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	15					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						GGCCTTCTCCGCAGGAGGCGC	0.617000												
HIST1H1D	3007	broad.mit.edu	37	6	26234947	26234947	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr6:26234947T>C	uc003nhd.2	-	1	270	c.215A>G	c.(214-216)TAC>TGC	p.Y72C		NM_005320	NP_005311	P16402	H13_HUMAN	histone cluster 1, H1d	72	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			skin(1)	1		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				TTCTACATCGTAGCCAGCAGC	0.552000												
GPX6	257202	broad.mit.edu	37	6	28478608	28478608	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr6:28478608A>G	uc011dlj.1	-	2	211	c.161T>C	c.(160-162)ATC>ACC	p.I54T	GPX6_uc010jrg.1_RNA	NM_182701	NP_874360	P59796	GPX6_HUMAN	glutathione peroxidase 6 precursor	54					response to oxidative stress	extracellular region	glutathione peroxidase activity			ovary(3)|pancreas(1)|skin(1)	5					Glutathione(DB00143)	CTTGAATTGGATGTACTCCTC	0.478000												
HLA-DPA1	3113	broad.mit.edu	37	6	33036858	33036858	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr6:33036858T>C	uc003ocs.1	-	3	597	c.566A>G	c.(565-567)GAG>GGG	p.E189G	HLA-DPA1_uc010juk.2_Missense_Mutation_p.E189G|HLA-DPA1_uc003oct.1_Missense_Mutation_p.E189G	NM_033554	NP_291032	P20036	DPA1_HUMAN	major histocompatibility complex, class II, DP	189	Alpha-2.|Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			skin(1)	1						ATAGAAGTCCTCTGCTGAGGG	0.557000												
GRIK2	2898	broad.mit.edu	37	6	102307263	102307263	+	Silent	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr6:102307263C>A	uc003pqp.3	+	10	1668	c.1419C>A	c.(1417-1419)ATC>ATA	p.I473I	GRIK2_uc003pqn.2_Silent_p.I473I|GRIK2_uc003pqo.3_Silent_p.I473I|GRIK2_uc010kcw.2_Silent_p.I473I	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	473	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TATCTACAATCCTTGGCTTTA	0.393000												
C6orf58	352999	broad.mit.edu	37	6	127901484	127901484	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr6:127901484C>A	uc003qbh.2	+	3	475	c.463C>A	c.(463-465)CAA>AAA	p.Q155K		NM_001010905	NP_001010905	Q6P5S2	CF058_HUMAN	hypothetical protein LOC352999 precursor	155						extracellular region					0				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		ATCATCAGACCAAGTCAGGCT	0.398000												
LAMA2	3908	broad.mit.edu	37	6	129381032	129381032	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr6:129381032T>A	uc003qbn.2	+	3	492	c.387T>A	c.(385-387)GAT>GAA	p.D129E	LAMA2_uc003qbo.2_Missense_Mutation_p.D129E	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	129	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TTACCCTGGATTTACAGCAGG	0.363000												
MOXD1	26002	broad.mit.edu	37	6	132618968	132618968	+	Silent	SNP	T	T	C	rs144497399		TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr6:132618968T>C	uc003qdf.2	-	11	1734	c.1635A>G	c.(1633-1635)CCA>CCG	p.P545P	MOXD1_uc003qde.2_Silent_p.P477P	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	545	Lumenal (Potential).				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		TCACATTCACTGGCAGGCTGA	0.398000												
SYNE1	23345	broad.mit.edu	37	6	152469370	152469370	+	Silent	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr6:152469370A>G	uc010kiw.2	-	137	25388	c.24786T>C	c.(24784-24786)GCT>GCC	p.A8262A	SYNE1_uc010kiv.2_Silent_p.A2786A|SYNE1_uc003qos.3_Silent_p.A2786A|SYNE1_uc003qot.3_Silent_p.A8191A|SYNE1_uc003qou.3_Silent_p.A8262A|SYNE1_uc003qop.3_Silent_p.A424A|SYNE1_uc011eez.1_Silent_p.A464A|SYNE1_uc003qoq.3_Silent_p.A464A|SYNE1_uc003qor.3_Silent_p.A1162A	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8262	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGAGGGGCTGAGCGAGCGAGA	0.632000										HNSCC(10;0.0054)		
SYNE1	23345	broad.mit.edu	37	6	152671375	152671375	+	Silent	SNP	G	G	A	rs146547806		TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr6:152671375G>A	uc010kiw.2	-	72	12431	c.11829C>T	c.(11827-11829)GGC>GGT	p.G3943G	SYNE1_uc003qot.3_Intron|SYNE1_uc003qou.3_Silent_p.G3943G|SYNE1_uc010kja.1_Silent_p.G648G	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3943	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCACCAGTCTGCCAGACATCT	0.542000										HNSCC(10;0.0054)		
TAGAP	117289	broad.mit.edu	37	6	159462400	159462400	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr6:159462400C>T	uc003qrz.2	-	6	795	c.463G>A	c.(463-465)GCT>ACT	p.A155T	TAGAP_uc011eft.1_Missense_Mutation_p.A92T|TAGAP_uc003qsa.2_5'UTR|TAGAP_uc003qsb.2_Missense_Mutation_p.A155T|uc003qsc.2_5'Flank	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	155	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		AAGACCACAGCGAGGAGGTGC	0.552000												
C7orf70	84792	broad.mit.edu	37	7	6370607	6370607	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:6370607G>T	uc003spu.2	-	2	647	c.179C>A	c.(178-180)GCA>GAA	p.A60E		NM_001037163	NP_001032240	Q7Z4H9	SIPAR_HUMAN	hypothetical protein LOC84792	60						nucleus					0						CAGTGATAATGCCTCACTTTG	0.507000												
ICA1	3382	broad.mit.edu	37	7	8167572	8167572	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:8167572T>C	uc003srm.2	-	13	1328	c.1261A>G	c.(1261-1263)ACA>GCA	p.T421A	ICA1_uc010ktr.2_Missense_Mutation_p.T450A|ICA1_uc003srl.2_Missense_Mutation_p.T409A|ICA1_uc003srn.3_Missense_Mutation_p.T347A|ICA1_uc003srp.3_Missense_Mutation_p.T420A|ICA1_uc010kts.2_RNA|ICA1_uc003srq.2_Missense_Mutation_p.T421A|ICA1_uc003srr.2_Missense_Mutation_p.T420A|ICA1_uc003sro.3_Missense_Mutation_p.T421A	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	421					neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		CCTGAGCCTGTCTGGGCCTTG	0.547000												
AOAH	313	broad.mit.edu	37	7	36588291	36588291	+	Silent	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:36588291A>G	uc003tfh.3	-	15	1461	c.1060T>C	c.(1060-1062)TTG>CTG	p.L354L	AOAH_uc010kxf.2_Silent_p.L354L|AOAH_uc011kba.1_Silent_p.L322L	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	354					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						TTTCTAGACAAGCTGAGAAGG	0.418000												
ELMO1	9844	broad.mit.edu	37	7	37272780	37272780	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:37272780A>G	uc003tfk.1	-	8	776	c.469T>C	c.(469-471)TTC>CTC	p.F157L	ELMO1_uc011kbc.1_Missense_Mutation_p.F61L|ELMO1_uc010kxg.1_Missense_Mutation_p.F157L	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	157					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GTCAGGGTGAAGGACAGCATG	0.498000												
POM121	9883	broad.mit.edu	37	7	72416237	72416237	+	Silent	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:72416237T>G	uc010lam.1	+	15	3888	c.2847T>G	c.(2845-2847)GTT>GTG	p.V949V	POM121_uc003twj.2_Silent_p.V949V	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1214	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				TTGTTGGTGTTGCACCTTTCG	0.632000												
LIMK1	3984	broad.mit.edu	37	7	73530169	73530169	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:73530169G>A	uc003uaa.1	+	13	1613	c.1448G>A	c.(1447-1449)CGT>CAT	p.R483H	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Missense_Mutation_p.R449H	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	483	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				GGGCTGGCGCGTCTCATGGTG	0.627000												
MAGI2	9863	broad.mit.edu	37	7	77885499	77885499	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:77885499A>C	uc003ugx.2	-	10	2062	c.1808T>G	c.(1807-1809)CTT>CGT	p.L603R	MAGI2_uc003ugy.2_Missense_Mutation_p.L603R|MAGI2_uc010ldx.1_Missense_Mutation_p.L212R|MAGI2_uc010ldy.1_Missense_Mutation_p.L212R|MAGI2_uc011kgr.1_Missense_Mutation_p.L435R|MAGI2_uc011kgs.1_Missense_Mutation_p.L440R	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	603						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TAAGGTCATAAGTTCAGCTTG	0.522000												
PPP1R9A	55607	broad.mit.edu	37	7	94539454	94539454	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:94539454G>A	uc003unp.2	+	2	311	c.29G>A	c.(28-30)CGA>CAA	p.R10Q	PPP1R9A_uc010lfj.2_Missense_Mutation_p.R10Q|PPP1R9A_uc011kif.1_Missense_Mutation_p.R10Q|PPP1R9A_uc003unq.2_Missense_Mutation_p.R10Q|PPP1R9A_uc011kig.1_Missense_Mutation_p.R10Q	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	10	Actin-binding.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			TCAGGTGAACGAACCACTCTC	0.413000										HNSCC(28;0.073)		
MUC17	140453	broad.mit.edu	37	7	100683595	100683595	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:100683595T>G	uc003uxp.1	+	3	8951	c.8898T>G	c.(8896-8898)AGT>AGG	p.S2966R	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2966	Extracellular (Potential).|Ser-rich.|48.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTGAAGCTAGTTCTTCTCCTA	0.517000												
MUC17	140453	broad.mit.edu	37	7	100685676	100685676	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:100685676T>G	uc003uxp.1	+	3	11032	c.10979T>G	c.(10978-10980)GTT>GGT	p.V3660G	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3660	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|58.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACACTTCCTGTTGACACCAGC	0.498000												
RELN	5649	broad.mit.edu	37	7	103179704	103179704	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:103179704T>G	uc003vca.2	-	45	7161	c.7001A>C	c.(7000-7002)AAA>ACA	p.K2334T	RELN_uc010liz.2_Missense_Mutation_p.K2334T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2334					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AAGCAGCCATTTCCTACTATC	0.443000												
DOCK4	9732	broad.mit.edu	37	7	111580168	111580168	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:111580168T>C	uc003vfx.2	-	11	1243	c.974A>G	c.(973-975)TAC>TGC	p.Y325C	DOCK4_uc003vfy.2_Missense_Mutation_p.Y325C|DOCK4_uc003vga.1_Intron|DOCK4_uc010ljt.1_Missense_Mutation_p.Y325C	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	325					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				TTCTTACATGTATACTTTCAG	0.502000												
FLNC	2318	broad.mit.edu	37	7	128496648	128496648	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:128496648G>A	uc003vnz.3	+	44	7537	c.7328G>A	c.(7327-7329)CGG>CAG	p.R2443Q	FLNC_uc003voa.3_Missense_Mutation_p.R2410Q	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2443	Filamin 22.|Interaction with INPPL1.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						ATTGATGCCCGGGTGCACACA	0.672000												
CLCN1	1180	broad.mit.edu	37	7	143013331	143013331	+	Missense_Mutation	SNP	G	G	A	rs115379077	byFrequency	TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:143013331G>A	uc003wcr.1	+	1	113	c.26G>A	c.(25-27)CGT>CAT	p.R9H	CLCN1_uc011ktc.1_Translation_Start_Site	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	9	Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					TCACAGCAGCGTGGGGGTGAA	0.622000												
C8orf42	157695	broad.mit.edu	37	8	442692	442692	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr8:442692A>C	uc003wpd.2	-	3	839	c.265T>G	c.(265-267)TGG>GGG	p.W89G	C8orf42_uc011kwg.1_Missense_Mutation_p.W89G	NM_175075	NP_778250	Q86YL5	CH042_HUMAN	hypothetical protein LOC157695	89											0		Ovarian(12;0.0481)|Colorectal(14;0.0815)|Hepatocellular(245;0.0968)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;5.16e-14)|OV - Ovarian serous cystadenocarcinoma(5;7.35e-07)|BRCA - Breast invasive adenocarcinoma(11;4.17e-06)|COAD - Colon adenocarcinoma(149;0.0255)		AAATTGTCCCAAAATCCAGAT	0.393000												
CSMD1	64478	broad.mit.edu	37	8	2820743	2820743	+	Splice_Site	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr8:2820743C>T	uc011kwk.1	-	60	9847	c.9457_splice	c.e60+1	p.P3153_splice	CSMD1_uc011kwj.1_Splice_Site_p.P2482_splice|CSMD1_uc010lrg.2_Splice_Site_p.P1044_splice	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor							integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTAGAACTTACGGAGACACTG	0.542000												
FGFR1	2260	broad.mit.edu	37	8	38275476	38275476	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr8:38275476G>A	uc003xlp.2	-	12	2406	c.1464C>T	c.(1462-1464)TGC>TGT	p.C488C	FGFR1_uc010lwf.2_RNA|FGFR1_uc011lbo.1_Silent_p.C486C|FGFR1_uc011lbp.1_Silent_p.C399C|FGFR1_uc011lbq.1_Silent_p.C397C|FGFR1_uc010lwk.2_Silent_p.C478C	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	488	ATP.|Cytoplasmic (Potential).|Protein kinase.				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	CCTGCCCAAAGCAGCCCTCTC	0.542000		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome					
RGS20	8601	broad.mit.edu	37	8	54791938	54791938	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr8:54791938G>A	uc003xrp.2	+	2	378	c.286G>A	c.(286-288)GAG>AAG	p.E96K	RGS20_uc003xrq.2_Intron|RGS20_uc010lye.2_Intron|RGS20_uc010lyf.2_Intron|RGS20_uc003xrr.2_5'Flank|RGS20_uc003xrs.2_5'Flank|RGS20_uc003xrt.2_5'Flank	NM_170587	NP_733466	O76081	RGS20_HUMAN	regulator of G-protein signaling 20 isoform a	96					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)			ACCCCCTCCCGAGGCTCCCCG	0.726000												
XKR9	389668	broad.mit.edu	37	8	71646212	71646212	+	Silent	SNP	C	C	T	rs147423226	byFrequency	TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr8:71646212C>T	uc003xyq.2	+	5	1209	c.675C>T	c.(673-675)TTC>TTT	p.F225F	XKR9_uc010lze.2_Silent_p.F225F|XKR9_uc010lzd.2_Silent_p.F93F	NM_001011720	NP_001011720	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related	225	Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			TTCTACTATTCTTAAATGTTA	0.294000												
TRPA1	8989	broad.mit.edu	37	8	72981358	72981358	+	Missense_Mutation	SNP	T	T	G	rs141011241	byFrequency	TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr8:72981358T>G	uc003xza.2	-	3	519	c.344A>C	c.(343-345)AAG>ACG	p.K115T		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	115	Cytoplasmic (Potential).|ANK 2.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GAGAAGAAACTTAACGCTTTC	0.413000												
RIMS2	9699	broad.mit.edu	37	8	104948824	104948824	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr8:104948824A>C	uc003yls.2	+	11	1996	c.1755A>C	c.(1753-1755)GAA>GAC	p.E585D	RIMS2_uc003ylp.2_Missense_Mutation_p.E807D|RIMS2_uc003ylw.2_Missense_Mutation_p.E599D|RIMS2_uc003ylq.2_Missense_Mutation_p.E599D|RIMS2_uc003ylr.2_Missense_Mutation_p.E646D|RIMS2_uc003ylt.2_Missense_Mutation_p.E192D	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	869	C2 1.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AAACATTGGAACCCAAATGGA	0.353000										HNSCC(12;0.0054)		
TRAPPC9	83696	broad.mit.edu	37	8	141407835	141407835	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr8:141407835C>G	uc003yvj.2	-	7	1152	c.1018G>C	c.(1018-1020)GCG>CCG	p.A340P	TRAPPC9_uc003yvh.2_Missense_Mutation_p.A438P|TRAPPC9_uc003yvi.1_Missense_Mutation_p.A331P	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	340					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						ATCACTCCCGCATTCTTATAC	0.428000												
ZC3H3	23144	broad.mit.edu	37	8	144550422	144550422	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr8:144550422G>A	uc003yyd.2	-	8	2161	c.2132C>T	c.(2131-2133)ACG>ATG	p.T711M		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	711	C3H1-type 2.				mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			GGTCCCATCCGTTTTCTTGCA	0.652000												
KIAA1432	57589	broad.mit.edu	37	9	5720218	5720218	+	Silent	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr9:5720218T>G	uc003zji.2	+	4	333	c.240T>G	c.(238-240)ACT>ACG	p.T80T	KIAA1432_uc003zjh.2_Silent_p.T80T|KIAA1432_uc003zjl.3_Silent_p.T80T|KIAA1432_uc003zjj.1_5'UTR	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	159						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TGGTTGCTACTTCTGATGGAC	0.383000												
MPDZ	8777	broad.mit.edu	37	9	13126741	13126741	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr9:13126741C>T	uc010mia.1	-	32	4552	c.4495G>A	c.(4495-4497)GAA>AAA	p.E1499K	MPDZ_uc003zky.3_Missense_Mutation_p.E61K|MPDZ_uc010mib.2_Missense_Mutation_p.E204K|MPDZ_uc010mhx.2_Missense_Mutation_p.E321K|MPDZ_uc011lmm.1_Missense_Mutation_p.E358K|MPDZ_uc003zkz.3_Missense_Mutation_p.E192K|MPDZ_uc010mhy.2_Missense_Mutation_p.E1499K|MPDZ_uc010mhz.2_Missense_Mutation_p.E1466K|MPDZ_uc011lmn.1_Missense_Mutation_p.E1466K|MPDZ_uc003zlb.3_Missense_Mutation_p.E1499K	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1499	PDZ 9.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		GTATCTTCTTCGCTGATAGCA	0.413000												
FREM1	158326	broad.mit.edu	37	9	14788940	14788940	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr9:14788940A>C	uc003zlm.2	-	23	4744	c.4154T>G	c.(4153-4155)ATC>AGC	p.I1385S	FREM1_uc010mic.2_Intron	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1385	CSPG 10.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		CTTGATGGTGATTTGACAGTC	0.418000												
TOPORS	10210	broad.mit.edu	37	9	32542941	32542941	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr9:32542941C>T	uc003zrb.2	-	3	1749	c.1582G>A	c.(1582-1584)GAT>AAT	p.D528N	TOPORS_uc003zrc.2_Missense_Mutation_p.D461N	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	528	Interaction with p53/TP53.|Required for sumoylation and localization to discrete nuclear foci.|Interaction with SUMO1.|Interaction with TOP1.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		CTACTAACATCGCTATCACCA	0.388000												
ZNF658	26149	broad.mit.edu	37	9	40774112	40774112	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr9:40774112T>A	uc004abs.2	-	5	1315	c.1163A>T	c.(1162-1164)AAA>ATA	p.K388I	ZNF658_uc010mmm.1_Missense_Mutation_p.K388I|ZNF658_uc010mmn.1_Missense_Mutation_p.K388I	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	388	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TTTTCTGCATTTCCCATGTTC	0.398000												
TRPM3	80036	broad.mit.edu	37	9	73233962	73233962	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr9:73233962C>T	uc004aid.2	-	16	2387	c.2143G>A	c.(2143-2145)GAC>AAC	p.D715N	TRPM3_uc004ahu.2_Missense_Mutation_p.D545N|TRPM3_uc004ahv.2_Missense_Mutation_p.D517N|TRPM3_uc004ahw.2_Missense_Mutation_p.D587N|TRPM3_uc004ahx.2_Missense_Mutation_p.D574N|TRPM3_uc004ahy.2_Missense_Mutation_p.D577N|TRPM3_uc004ahz.2_Missense_Mutation_p.D564N|TRPM3_uc004aia.2_Missense_Mutation_p.D562N|TRPM3_uc004aib.2_Missense_Mutation_p.D552N|TRPM3_uc004aic.2_Missense_Mutation_p.D715N	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	740	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						AGCTGTTCGTCCTGCTTGTAG	0.552000												
NFIL3	4783	broad.mit.edu	37	9	94172104	94172104	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr9:94172104G>C	uc004arh.2	-	2	1308	c.913C>G	c.(913-915)CTC>GTC	p.L305V		NM_005384	NP_005375	Q16649	NFIL3_HUMAN	nuclear factor, interleukin 3 regulated	305	Necessary for transcriptional repression and sufficient for interaction with DR1.				circadian rhythm|immune response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0						ACATGCTTGAGTTCAACTGGA	0.502000												
OR13C4	138804	broad.mit.edu	37	9	107288559	107288559	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr9:107288559A>G	uc011lvn.1	-	1	932	c.932T>C	c.(931-933)CTG>CCG	p.L311P		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	311	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTTCCTGCTCAGCAAATATTT	0.343000												
TNC	3371	broad.mit.edu	37	9	117826111	117826111	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr9:117826111A>C	uc004bjj.3	-	12	4086	c.3724T>G	c.(3724-3726)TTC>GTC	p.F1242V	TNC_uc010mvf.2_Missense_Mutation_p.F1242V	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1242	Fibronectin type-III 7.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GTTGTGCTGAAGTCCTGAGTG	0.532000												
OR1J1	347168	broad.mit.edu	37	9	125239555	125239555	+	Silent	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr9:125239555A>G	uc011lyu.1	-	1	651	c.651T>C	c.(649-651)TCT>TCC	p.S217S	OR1J2_uc004bmj.1_Intron	NM_001004451	NP_001004451	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TGTGACCATAAGAAACCAGGA	0.488000												
LCN2	3934	broad.mit.edu	37	9	130911881	130911881	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr9:130911881A>G	uc004bto.1	+	1	150	c.77A>G	c.(76-78)GAC>GGC	p.D26G	LCN2_uc010mxq.1_Missense_Mutation_p.D26G|LCN2_uc011map.1_Missense_Mutation_p.D26G	NM_005564	NP_005555	P80188	NGAL_HUMAN	lipocalin 2 precursor	26					apoptosis|innate immune response|regulation of apoptosis|siderophore transport		iron ion binding|transporter activity				0						TCCACCTCAGACCTGATCCCA	0.647000												
KAL1	3730	broad.mit.edu	37	X	8555989	8555989	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chrX:8555989C>A	uc004csf.2	-	5	722	c.572G>T	c.(571-573)CGA>CTA	p.R191L		NM_000216	NP_000207	P23352	KALM_HUMAN	Kallmann syndrome 1 protein precursor	191	Fibronectin type-III 1.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			ovary(3)|pancreas(1)	4						TTCTGTAAATCGTAACTCTTT	0.413000												
RBBP7	5931	broad.mit.edu	37	X	16876866	16876866	+	Silent	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chrX:16876866G>A	uc004cxt.2	-	4	772	c.414C>T	c.(412-414)ATC>ATT	p.I138I	RBBP7_uc004cxs.1_Silent_p.I182I|RBBP7_uc004cxu.2_Silent_p.I129I|RBBP7_uc010nez.2_Silent_p.I7I	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	138	WD 2.				cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					TTGTAGCAATGATGTGAGGAT	0.378000												
CCNB3	85417	broad.mit.edu	37	X	50052016	50052016	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chrX:50052016T>G	uc004dox.3	+	6	1145	c.847T>G	c.(847-849)TTA>GTA	p.L283V	CCNB3_uc004doy.2_Missense_Mutation_p.L283V|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	283					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					CACCCATAAGTTATCATCTTT	0.413000												
WNK3	65267	broad.mit.edu	37	X	54263946	54263946	+	Silent	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chrX:54263946T>G	uc004dtd.1	-	20	4351	c.3912A>C	c.(3910-3912)ACA>ACC	p.T1304T	WNK3_uc004dtc.1_Silent_p.T1351T	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1304					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TTCCAAAAGATGTCATTTTTG	0.373000												
PJA1	64219	broad.mit.edu	37	X	68382960	68382960	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chrX:68382960C>T	uc004dxh.2	-	2	408	c.122G>A	c.(121-123)CGG>CAG	p.R41Q	PJA1_uc011mpi.1_5'UTR|PJA1_uc004dxg.2_Missense_Mutation_p.R41Q|PJA1_uc004dxi.2_5'UTR	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	41							zinc ion binding				0						AATCCTTTCCCGCTGGCTCGT	0.537000												
PHKA1	5255	broad.mit.edu	37	X	71830971	71830971	+	Silent	SNP	G	G	A	rs61732499	byFrequency	TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chrX:71830971G>A	uc004eax.3	-	22	2734	c.2433C>T	c.(2431-2433)ACC>ACT	p.T811T	PHKA1_uc004eay.3_Silent_p.T811T|PHKA1_uc011mqi.1_Silent_p.T752T	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	811	Calmodulin-binding (Potential).				glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					CATACAGCTCGGTAAGAAGCT	0.433000												
SLC16A2	6567	broad.mit.edu	37	X	73745699	73745699	+	Missense_Mutation	SNP	A	A	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chrX:73745699A>T	uc004ebt.2	+	4	1529	c.1363A>T	c.(1363-1365)ATC>TTC	p.I455F	SLC16A2_uc010nlr.1_Missense_Mutation_p.I130F	NM_006517	NP_006508	P36021	MOT8_HUMAN	solute carrier family 16, member 2	381	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|ovary(1)	3					Pyruvic acid(DB00119)	CAGTGACTCCATCCCTGGACT	0.527000												
ARMCX1	51309	broad.mit.edu	37	X	100808487	100808487	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chrX:100808487T>G	uc004ehv.2	+	4	945	c.574T>G	c.(574-576)TTC>GTC	p.F192V	ARMCX1_uc004ehw.2_Missense_Mutation_p.F192V	NM_016608	NP_057692	Q9P291	ARMX1_HUMAN	armadillo repeat containing, X-linked 1	192						integral to membrane	binding			ovary(3)|pancreas(1)	4						GAGAGGCAAGTTCAACTTTCC	0.493000												
PAK3	5063	broad.mit.edu	37	X	110463599	110463599	+	Missense_Mutation	SNP	A	A	T			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chrX:110463599A>T	uc004epa.2	+	15	1631	c.1604A>T	c.(1603-1605)AAA>ATA	p.K535I	PAK3_uc010npt.1_Missense_Mutation_p.K520I|PAK3_uc010npu.1_Missense_Mutation_p.K520I|PAK3_uc004eoz.2_Missense_Mutation_p.K520I|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.K556I|PAK3_uc010npw.1_Missense_Mutation_p.K541I	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	535					multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						CCATTTTTAAAATTAGCCAAG	0.408000										TSP Lung(19;0.15)		
TRPC5	7224	broad.mit.edu	37	X	111020004	111020004	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chrX:111020004G>A	uc004epl.1	-	11	3378	c.2459C>T	c.(2458-2460)TCC>TTC	p.S820F		NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	820	Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						GGCACCACTGGACCTTGGCAT	0.478000												
MAGEA6	4105	broad.mit.edu	37	X	151869966	151869966	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chrX:151869966A>G	uc004ffq.1	+	3	850	c.656A>G	c.(655-657)GAG>GGG	p.E219G	MAGEA6_uc004ffr.1_Missense_Mutation_p.E219G|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	219	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					GCCCCTGAGGAGAAAATCTGG	0.522000												
WBSCR27	155368	broad.mit.edu	37	7	73254452	73254453	+	Splice_Site	DEL	TG	TG	-			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr7:73254451_73254452CTG>C	uc003tzj.2	-	5	429	c.389_splice	c.e5-1	p.G130_splice	WBSCR27_uc011kfd.1_Intron	NM_152559	NP_689772	Q8N6F8	WBS27_HUMAN	Homo sapiens Williams Beuren syndrome chromosome region 27 (WBSCR27), mRNA.	130										NS(1)|central_nervous_system(1)|lung(2)|prostate(1)	5		Lung NSC(55;0.159)				TCGAAGGTCCCTGTGTGTGTGT	0.599												
TLE2	7089	broad.mit.edu	37	19	3028804	3028805	+	Splice_Site	INS	-	-	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:3028803_3028804T>TG	uc010dth.3	-	2	288	c.25_splice	c.e2-1	p.T9_splice	TLE2_uc002lww.3_Splice_Site_p.T9_splice|TLE2_uc010xhc.2_Splice_Site|TLE2_uc010dti.3_Splice_Site_p.T22_splice|TLE2_uc010xhd.1_Splice_Site_p.T9_splice	NM_003260	NP_003251	Q04725	TLE2_HUMAN	Homo sapiens transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) (TLE2), transcript variant 1, mRNA.	9	Gln-rich.				Wnt receptor signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent	nucleus	protein binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGCGGGGTCTGGGGGGGGTGT	0.624												
RUFY3	22902	broad.mit.edu	37	4	71644096	71644098	+	In_Frame_Del	DEL	AAC	AAC	-			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr4:71644096_71644098delAAC	uc003hfq.2	+	8	1430_1432	c.835_837delAAC	c.(835-837)AACdel	p.N280del	RUFY3_uc003hfp.3_In_Frame_Del_p.N340del|RUFY3_uc011cax.1_In_Frame_Del_p.N298del|RUFY3_uc003hfr.2_In_Frame_Del_p.N280del|RUFY3_uc011cay.1_In_Frame_Del_p.N216del	NM_014961	NP_055776	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3 isoform 2	280	Potential.				negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)			TGCTACTGTAAACAACCTTCAGG	0.315												
KIAA2026	158358	broad.mit.edu	37	9	5968162	5968162	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr9:5968162delT	uc003zjq.3	-	3	2285	c.2069delA	c.(2068-2070)AAGfs	p.K690fs		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	690	Lys-rich.									ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTTCAATTTCTTTTTTTTCTT	0.333												
FAT2	2196	broad.mit.edu	37	5	150946485	150946486	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr5:150946484_150946485CAT>C	uc003lue.4	-	0	2021_2022	c.2008_2009ATG>G	c.(2008-2010)tgtfs	p.C670fs	FAT2_uc010jhx.1_Frame_Shift_Del_p.C670fs	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	Homo sapiens FAT tumor suppressor homolog 2 (Drosophila) (FAT2), mRNA.	670					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGTTTTATCACATGTTACAGGA	0.416												
SLC26A7	115111	broad.mit.edu	37	8	92406218	92406219	+	Frame_Shift_Ins	INS	-	-	T	rs149495064		TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr8:92406217_92406218A>AT	uc003yez.3	+	17	2124_2125	c.1885_1886A>AT	c.(1885-1887)attfs	p.I629fs	SLC26A7_uc003yex.3_Frame_Shift_Ins_p.I629fs|SLC26A7_uc003yey.3_Non-coding_Transcript|SLC26A7_uc003yfa.3_Frame_Shift_Ins_p.I629fs	NM_134266	NP_599028	Q8TE54	S26A7_HUMAN	Homo sapiens solute carrier family 26, member 7 (SLC26A7), transcript variant 2, mRNA.	629	STAS.					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			AGAGAAACCAATTTTTTTTGAA	0.342												
OR52D1	390066	broad.mit.edu	37	11	5509961	5509961	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:5509960_5509960TA>T	uc010qzg.2	+	0	46	c.24_24TA>T	c.(22-24)gatfs	p.D8fs	HBG1_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc021qcv.1_Intron|OR51B5_uc001maq.2_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	Homo sapiens olfactory receptor, family 52, subfamily D, member 1 (OR52D1), mRNA.	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCTCAGTGATAACCATCTTC	0.453												
KDM4D	55693	broad.mit.edu	37	11	94730807	94730808	+	Frame_Shift_Ins	INS	-	-	A	rs142280183	by1000genomes	TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr11:94730806_94730807T>TA	uc021qow.1	+	0	270_271	c.270_271T>TA	c.(268-273)cataaafs	p.H90fs	KDM4D_uc001pfe.3_Frame_Shift_Ins_p.H90fs	NM_018039	NP_060509	Q6B0I6	KDM4D_HUMAN	Homo sapiens lysine (K)-specific demethylase 4D (KDM4D), mRNA.	90					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(16)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						CTCAATACCATAAAAAAAAGAA	0.455												
AMIGO2	347902	broad.mit.edu	37	12	47471749	47471749	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr12:47471748_47471748TC>T	uc001rpm.3	-	2	1693	c.1038_1038GA>A	c.(1036-1038)ggafs	p.G346fs	FAM113B_uc001rpn.3_5'Flank|AMIGO2_uc001rpk.3_Frame_Shift_Del_p.G346fs|AMIGO2_uc001rpl.3_Frame_Shift_Del_p.G346fs|AMIGO2_uc021qxg.1_Frame_Shift_Del_p.G346fs	NM_001143668	NP_862830	Q86SJ2	AMGO2_HUMAN	Homo sapiens adhesion molecule with Ig-like domain 2 (AMIGO2), transcript variant 1, mRNA.	346	Ig-like C2-type.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					TAACCAGACTTCCATTGTGAA	0.423												
TLE2	7089	broad.mit.edu	37	19	3028804	3028805	+	Splice_Site	INS	-	-	G			TCGA-CD-A48A-01A-12D-A24D-08	TCGA-CD-A48A-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c2f0820b-e38e-48ce-a676-f2cf70c06101	f7e6028e-6fd8-43b1-b881-d923a937ed6c	g.chr19:3028803_3028804T>TG	uc010dth.3	-	2	288	c.25_splice	c.e2-1	p.T9_splice	TLE2_uc002lww.3_Splice_Site_p.T9_splice|TLE2_uc010xhc.2_Splice_Site|TLE2_uc010dti.3_Splice_Site_p.T22_splice|TLE2_uc010xhd.1_Splice_Site_p.T9_splice	NM_003260	NP_003251	Q04725	TLE2_HUMAN	Homo sapiens transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) (TLE2), transcript variant 1, mRNA.	9	Gln-rich.				Wnt receptor signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent	nucleus	protein binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGCGGGGTCTGGGGGGGGTGT	0.624