Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
EPHA8	2046	broad.mit.edu	37	1	22927491	22927491	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr1:22927491C>T	uc001bfx.1	+	15	2764	c.2639C>T	c.(2638-2640)GCG>GTG	p.A880V		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	880	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AAGGACCGGGCGCAGCGGCCT	0.662000												
CD53	963	broad.mit.edu	37	1	111441780	111441780	+	Missense_Mutation	SNP	G	G	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr1:111441780G>T	uc001dzw.2	+	9	794	c.623G>T	c.(622-624)TGC>TTC	p.C208F	CD53_uc001dzx.2_Missense_Mutation_p.C208F|CD53_uc010owa.1_Missense_Mutation_p.C149F|CD53_uc001dzy.2_Missense_Mutation_p.C153F	NM_001040033	NP_001035122	P19397	CD53_HUMAN	CD53 antigen	208	Cytoplasmic (Potential).				signal transduction	integral to membrane|plasma membrane					0		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)		ACCCTGAACTGCCAGATTGAC	0.443000												
MAGI3	260425	broad.mit.edu	37	1	114225853	114225853	+	Silent	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr1:114225853G>A	uc001edk.2	+	21	3844	c.3663G>A	c.(3661-3663)TCG>TCA	p.S1221S	MAGI3_uc001edi.3_3'UTR|MAGI3_uc010owm.1_3'UTR|MAGI3_uc001edj.2_3'UTR|MAGI3_uc009wgo.2_RNA	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1246					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGGTAGATCGGTTAGTCCCA	0.398000												
PDE4DIP	9659	broad.mit.edu	37	1	144917576	144917576	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr1:144917576G>A	uc001elw.3	-	12	1819	c.1528C>T	c.(1528-1530)CGT>TGT	p.R510C	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.R576C|PDE4DIP_uc001emc.1_Missense_Mutation_p.R510C|PDE4DIP_uc001emd.1_Missense_Mutation_p.R510C|PDE4DIP_uc001emb.1_Missense_Mutation_p.R673C|PDE4DIP_uc001eme.1_Missense_Mutation_p.R39C|PDE4DIP_uc001emf.1_Missense_Mutation_p.R297C	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	510	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ACAGCAAGACGAAGCTGGCGC	0.443000			T	PDGFRB	MPD							
OR6K3	391114	broad.mit.edu	37	1	158687142	158687142	+	Missense_Mutation	SNP	G	G	A	rs79482939	by1000genomes	TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr1:158687142G>A	uc010pip.1	-	1	812	c.812C>T	c.(811-813)TCA>TTA	p.S271L		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	271	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					GTACATGAGTGATACACTGCC	0.453000												
SIPA1L2	57568	broad.mit.edu	37	1	232650895	232650895	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr1:232650895G>A	uc001hvg.2	-	1	349	c.191C>T	c.(190-192)CCG>CTG	p.P64L		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	64					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				ACCATTAGCCGGACCACCACC	0.483000												
OR2T12	127064	broad.mit.edu	37	1	248457935	248457935	+	Missense_Mutation	SNP	C	C	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr1:248457935C>A	uc010pzj.1	-	1	946	c.946G>T	c.(946-948)GCC>TCC	p.A316S		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	316	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GACCTGTGGGCCTCATTTTGC	0.418000												
CCNY	219771	broad.mit.edu	37	10	35772377	35772377	+	Missense_Mutation	SNP	C	C	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr10:35772377C>A	uc001iyw.3	+	2	380	c.200C>A	c.(199-201)ACA>AAA	p.T67K	CCNY_uc001iyu.3_Missense_Mutation_p.T13K|CCNY_uc001iyv.3_Missense_Mutation_p.T13K|CCNY_uc001iyx.3_Missense_Mutation_p.T13K|CCNY_uc009xmb.2_Intron|CCNY_uc010qet.1_5'UTR	NM_145012	NP_659449	Q8ND76	CCNY_HUMAN	cyclin Y isoform 1	67					cell division|G2/M transition of mitotic cell cycle|positive regulation of cyclin-dependent protein kinase activity|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	cyclin-dependent protein kinase regulator activity|protein kinase binding				0						CGGGCCAGCACAATATTCCTC	0.358000												
GJD4	219770	broad.mit.edu	37	10	35896709	35896709	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr10:35896709G>A	uc001iyy.1	+	2	426	c.268G>A	c.(268-270)GCC>ACC	p.A90T		NM_153368	NP_699199	Q96KN9	CXD4_HUMAN	connexin40.1	90	Helical; (Potential).				cell communication	connexon complex|integral to membrane				large_intestine(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CCTCCCCTCCGCCGTCTTCAG	0.711000												
OR51T1	401665	broad.mit.edu	37	11	4904053	4904053	+	Silent	SNP	G	G	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr11:4904053G>T	uc010qyp.1	+	1	1005	c.1005G>T	c.(1003-1005)CTG>CTT	p.L335L		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	308	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTTCCAGCTGCTCCAATCCA	0.458000												
OR4D10	390197	broad.mit.edu	37	11	59245145	59245145	+	Silent	SNP	T	T	C			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr11:59245145T>C	uc001nnz.1	+	1	243	c.243T>C	c.(241-243)GTT>GTC	p.V81V		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TGCCCAAGGTTCTGGTGGACC	0.433000												
OVOL1	5017	broad.mit.edu	37	11	65561652	65561652	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr11:65561652C>T	uc001ofp.2	+	2	567	c.251C>T	c.(250-252)TCT>TTT	p.S84F	OVOL1_uc001ofq.2_Missense_Mutation_p.S22F	NM_004561	NP_004552	O14753	OVOL1_HUMAN	OVO-like 1 binding protein	84					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				READ - Rectum adenocarcinoma(159;0.17)		CAGCTGCCCTCTGAAGACATG	0.637000												
ROBO4	54538	broad.mit.edu	37	11	124766118	124766118	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr11:124766118G>A	uc001qbg.2	-	4	795	c.655C>T	c.(655-657)CGC>TGC	p.R219C	ROBO4_uc010sas.1_Missense_Mutation_p.R74C|ROBO4_uc001qbh.2_Missense_Mutation_p.R109C|ROBO4_uc001qbi.2_5'Flank|ROBO4_uc010sat.1_5'Flank	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	219	Ig-like C2-type 2.				angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CGGGCTGCGCGGCTCTCCCTA	0.617000												
AKAP3	10566	broad.mit.edu	37	12	4736611	4736611	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr12:4736611C>T	uc001qnb.3	-	4	1686	c.1457G>A	c.(1456-1458)CGT>CAT	p.R486H		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	486					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						TGCAGGCTTACGCTGTGTGTT	0.428000												
APOBEC1	339	broad.mit.edu	37	12	7805130	7805130	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr12:7805130C>T	uc001qtb.2	-	3	380	c.346G>A	c.(346-348)GTA>ATA	p.V116I	APOBEC1_uc001qtc.2_Missense_Mutation_p.V71I|APOBEC1_uc010sgf.1_Missense_Mutation_p.V116I	NM_001644	NP_001635	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme	116					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding				0						AGCCGAGCTACGTAGATCACT	0.488000												
BAZ2A	11176	broad.mit.edu	37	12	57005736	57005736	+	Missense_Mutation	SNP	G	G	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr12:57005736G>T	uc001slq.1	-	6	1630	c.1436C>A	c.(1435-1437)GCA>GAA	p.A479E	BAZ2A_uc001slp.1_Missense_Mutation_p.A477E|BAZ2A_uc009zow.1_Missense_Mutation_p.A447E	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	479					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						TAAGGAGACTGCTGGGAGGAC	0.547000												
RASSF3	283349	broad.mit.edu	37	12	65085273	65085273	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr12:65085273C>T	uc001ssd.2	+	4	601	c.481C>T	c.(481-483)CGG>TGG	p.R161W	RASSF3_uc009zqn.2_RNA|RASSF3_uc001sse.2_Missense_Mutation_p.R91W	NM_178169	NP_835463	Q86WH2	RASF3_HUMAN	Ras association (RalGDS/AF-6) domain family	161	Ras-associating.				signal transduction	cytoplasm|microtubule	identical protein binding				0			Lung(2;0.00133)|LUAD - Lung adenocarcinoma(6;0.0665)|LUSC - Lung squamous cell carcinoma(43;0.132)	GBM - Glioblastoma multiforme(28;0.0611)		GCTCTCAGACCGGGAACATCC	0.478000												
NBEA	26960	broad.mit.edu	37	13	36046612	36046612	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr13:36046612C>T	uc001uvb.2	+	41	6730	c.6524C>T	c.(6523-6525)ACG>ATG	p.T2175M	NBEA_uc010abi.2_Missense_Mutation_p.T831M|NBEA_uc010tee.1_Translation_Start_Site	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2175						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TCCATCACCACGACAGAAATC	0.532000												
SYNE2	23224	broad.mit.edu	37	14	64449413	64449413	+	Missense_Mutation	SNP	C	C	G			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr14:64449413C>G	uc001xgm.2	+	17	2132	c.1902C>G	c.(1900-1902)TTC>TTG	p.F634L	SYNE2_uc001xgl.2_Missense_Mutation_p.F634L	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	634	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CAGGAAATTTCTTAGTCGAAG	0.378000												
SIPA1L1	26037	broad.mit.edu	37	14	72139105	72139105	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr14:72139105G>A	uc001xms.2	+	9	3218	c.2870G>A	c.(2869-2871)CGA>CAA	p.R957Q	SIPA1L1_uc001xmt.2_Missense_Mutation_p.R957Q|SIPA1L1_uc001xmu.2_Missense_Mutation_p.R957Q|SIPA1L1_uc001xmv.2_Missense_Mutation_p.R957Q|SIPA1L1_uc010ttm.1_Missense_Mutation_p.R432Q	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	957					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ATGACTCTGCGAAGAAATGGG	0.483000												
SLC12A6	9990	broad.mit.edu	37	15	34528245	34528245	+	Silent	SNP	T	T	C			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr15:34528245T>C	uc001zhw.2	-	23	3362	c.3198A>G	c.(3196-3198)GAA>GAG	p.E1066E	SLC12A6_uc001zhv.2_Silent_p.E1015E|SLC12A6_uc001zhx.2_Silent_p.E1051E|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Silent_p.E1007E|SLC12A6_uc001zib.2_Silent_p.E1057E|SLC12A6_uc001zic.2_Silent_p.E1066E|SLC12A6_uc010bau.2_Silent_p.E1066E|SLC12A6_uc001zid.2_Silent_p.E1007E|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Silent_p.E878E	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	1066	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	CCTGGAATCCTTCCATTGACT	0.453000												
NOP10	55505	broad.mit.edu	37	15	34634268	34634268	+	Silent	SNP	A	A	G			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr15:34634268A>G	uc001zie.1	-	2	184	c.96T>C	c.(94-96)CCT>CCC	p.P32P	C15orf55_uc010ucc.1_5'Flank|C15orf55_uc010ucd.1_5'Flank	NM_018648	NP_061118	Q9NPE3	NOP10_HUMAN	nucleolar protein family A, member 3	32					pseudouridine synthesis|rRNA processing	Cajal body|nucleolus|small nucleolar ribonucleoprotein complex	protein binding				0						AGAACCGAGCAGGATGGGCTG	0.537000												
GJD2	57369	broad.mit.edu	37	15	35045227	35045227	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr15:35045227G>A	uc001zis.1	-	2	418	c.418C>T	c.(418-420)CGA>TGA	p.R140*	uc001zit.1_5'Flank	NM_020660	NP_065711	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	140	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		TTATCTTCTCGTTTGCCCCCA	0.532000												
MYO9A	4649	broad.mit.edu	37	15	72227776	72227776	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr15:72227776T>A	uc002atl.3	-	17	2901	c.2428A>T	c.(2428-2430)AGA>TGA	p.R810*	MYO9A_uc010biq.2_Nonsense_Mutation_p.R430*|MYO9A_uc002atn.1_Nonsense_Mutation_p.R791*	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	810					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						CTTGATAGTCTGCTCTGGCGA	0.398000												
ADAMTSL3	57188	broad.mit.edu	37	15	84690187	84690187	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr15:84690187G>A	uc002bjz.3	+	26	4523	c.4299G>A	c.(4297-4299)TGG>TGA	p.W1433*	ADAMTSL3_uc010bmt.1_Nonsense_Mutation_p.W1433*|ADAMTSL3_uc010bmu.1_Nonsense_Mutation_p.W1433*	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1433	TSP type-1 8.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTGGTAACTGGTCACATTGTT	0.512000												
CHTF18	63922	broad.mit.edu	37	16	844151	844151	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr16:844151C>T	uc002cke.3	+	15	1963	c.1900C>T	c.(1900-1902)CGT>TGT	p.R634C	CHTF18_uc002ckf.3_Missense_Mutation_p.R662C|CHTF18_uc010brf.2_Missense_Mutation_p.R216C|CHTF18_uc002ckg.3_Missense_Mutation_p.R152C	NM_022092	NP_071375	Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor	634					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			kidney(1)	1		Hepatocellular(780;0.00335)				GCGATTCTACCGTGTCCTGCA	0.682000												
FLYWCH2	114984	broad.mit.edu	37	16	2946611	2946611	+	Missense_Mutation	SNP	T	T	G			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr16:2946611T>G	uc002csa.2	+	3	532	c.161T>G	c.(160-162)GTG>GGG	p.V54G	FLYWCH2_uc010uwj.1_Missense_Mutation_p.V54G|FLYWCH2_uc010uwk.1_Missense_Mutation_p.V54G	NM_138439	NP_612448	Q96CP2	FWCH2_HUMAN	FLYWCH family member 2	54											0						AGCACCAAGGTGGCGGGGGCC	0.667000												
GRIN2A	2903	broad.mit.edu	37	16	10274134	10274134	+	Silent	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr16:10274134G>A	uc002czo.3	-	2	683	c.135C>T	c.(133-135)GAC>GAT	p.D45D	GRIN2A_uc010uym.1_Silent_p.D45D|GRIN2A_uc002czr.3_Silent_p.D45D|GRIN2A_uc010buk.2_Silent_p.D45D	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	45	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCTCTGTCACGTCGTGGCTGT	0.692000												
NOD2	64127	broad.mit.edu	37	16	50750497	50750497	+	Splice_Site	SNP	G	G	C			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr16:50750497G>C	uc002egm.1	+	5	2568	c.2463_splice	c.e5-1	p.Y821_splice	NOD2_uc010cbl.1_Splice_Site_p.Y599_splice|NOD2_uc010cbm.1_Splice_Site_p.Y599_splice|NOD2_uc010cbn.1_Intron|NOD2_uc010cbo.1_Intron|NOD2_uc010cbp.1_Intron|NOD2_uc010cbq.1_Splice_Site|NOD2_uc010cbr.1_Intron	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain						activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				TGTCTCTTTAGTTTGCGCGAT	0.413000												
IRX5	10265	broad.mit.edu	37	16	54967637	54967637	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr16:54967637C>T	uc002ehv.2	+	3	1304	c.1304C>T	c.(1303-1305)CCG>CTG	p.P435L	IRX5_uc002ehw.2_Missense_Mutation_p.P369L	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	435					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						ACAACCGGTCCGGGGTCTCAT	0.592000												
CAMTA2	23125	broad.mit.edu	37	17	4875783	4875783	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr17:4875783G>A	uc002gah.1	-	16	2660	c.2552C>T	c.(2551-2553)TCC>TTC	p.S851F	CAMTA2_uc010cku.1_Missense_Mutation_p.S874F|CAMTA2_uc002gag.1_Missense_Mutation_p.S850F|CAMTA2_uc002gai.1_Missense_Mutation_p.S853F|CAMTA2_uc010ckv.1_Missense_Mutation_p.S498F	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	851					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						TGACGTGACGGAAAAGGTGCC	0.642000												
DLG4	1742	broad.mit.edu	37	17	7106879	7106879	+	Silent	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr17:7106879C>T	uc002get.3	-	8	1699	c.498G>A	c.(496-498)GTG>GTA	p.V166V	DLG4_uc010vtm.1_RNA|DLG4_uc010vtn.1_Silent_p.V63V|DLG4_uc010cly.2_Silent_p.V120V|DLG4_uc010vto.1_Silent_p.V163V|DLG4_uc002geu.2_Silent_p.V120V	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	123	PDZ 1.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						CGCGCACGTCCACTTCATTTA	0.632000												
ARHGEF15	22899	broad.mit.edu	37	17	8216418	8216418	+	Silent	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr17:8216418C>T	uc002glc.2	+	3	901	c.780C>T	c.(778-780)GCC>GCT	p.A260A	ARHGEF15_uc002glb.1_3'UTR|ARHGEF15_uc002gld.2_Silent_p.A260A|ARHGEF15_uc010vuw.1_Intron	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	260					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GTCACCCTGCCGTTGTCCTCA	0.657000												
ARHGEF15	22899	broad.mit.edu	37	17	8219149	8219149	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr17:8219149G>A	uc002glc.2	+	8	1619	c.1498G>A	c.(1498-1500)GCT>ACT	p.A500T	ARHGEF15_uc002gld.2_Missense_Mutation_p.A500T|ARHGEF15_uc010vuw.1_Missense_Mutation_p.A389T	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	500	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GCATGCCCACGCTGTGGGGCC	0.582000												
MYH10	4628	broad.mit.edu	37	17	8380351	8380351	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr17:8380351C>T	uc002gll.2	-	40	5725	c.5629G>A	c.(5629-5631)GCT>ACT	p.A1877T	MYH10_uc002glm.2_Missense_Mutation_p.A1908T|MYH10_uc010cnx.2_Missense_Mutation_p.A1886T	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1877	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TTCATCCGAGCGTTGGCCTTC	0.567000												
ALKBH5	54890	broad.mit.edu	37	17	18110185	18110185	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr17:18110185C>T	uc010cpw.2	+	3	1599	c.908C>T	c.(907-909)CCA>CTA	p.P303L	ALKBH5_uc010cpx.2_RNA	NM_017758	NP_060228	Q6P6C2	ALKB5_HUMAN	alkB, alkylation repair homolog 5	303						integral to membrane	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0	all_neural(463;0.228)					TCCGTGTTACCACCCAGCTAT	0.572000												
PIGS	94005	broad.mit.edu	37	17	26890883	26890883	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr17:26890883C>T	uc002hbo.2	-	4	702	c.329G>A	c.(328-330)AGG>AAG	p.R110K	PIGS_uc002hbn.2_Missense_Mutation_p.R102K|PIGS_uc010wap.1_Missense_Mutation_p.R49K	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	110	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					GTCCAAAGCCCTCCGATAGGC	0.498000												
LRRC37B	114659	broad.mit.edu	37	17	30349784	30349784	+	Missense_Mutation	SNP	A	A	G			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr17:30349784A>G	uc002hgu.2	+	1	1630	c.1619A>G	c.(1618-1620)CAG>CGG	p.Q540R	LRRC37B_uc010wbx.1_Missense_Mutation_p.Q458R|LRRC37B_uc010csu.2_Missense_Mutation_p.Q540R	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	540	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				AGCCCAAAGCAGAGGCTCCGC	0.537000												
ACE	1636	broad.mit.edu	37	17	61568741	61568741	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr17:61568741C>T	uc002jau.1	+	19	2933	c.2911C>T	c.(2911-2913)CGG>TGG	p.R971W	ACE_uc002jav.1_Missense_Mutation_p.R397W|ACE_uc010ddv.1_Missense_Mutation_p.R198W|ACE_uc010wpj.1_Missense_Mutation_p.R397W|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.R217W	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	971	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CAAGGACTTCCGGTACATCCA	0.607000												
ZFP161	7541	broad.mit.edu	37	18	5291265	5291265	+	Silent	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr18:5291265G>A	uc002kmq.2	-	4	1103	c.942C>T	c.(940-942)TTC>TTT	p.F314F	ZFP161_uc002kmr.2_Silent_p.F314F|ZFP161_uc010dkp.2_Silent_p.F314F	NM_003409	NP_003400	O43829	ZF161_HUMAN	zinc finger protein 161 homolog	314	C2H2-type 2.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CCTGTGTGGTGAAACCTTTTG	0.473000												
NFATC1	4772	broad.mit.edu	37	18	77246792	77246792	+	Silent	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr18:77246792G>A	uc010xfg.1	+	9	3090	c.2637G>A	c.(2635-2637)CCG>CCA	p.P879P	NFATC1_uc002lnd.2_Intron|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Intron|NFATC1_uc010xfj.1_Silent_p.P407P|NFATC1_uc002lnf.2_Silent_p.P866P|NFATC1_uc002lng.2_Intron|NFATC1_uc010xfk.1_Intron	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	879	Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		AGCACCTGCCGTCCACGGTCC	0.706000												
FEM1A	55527	broad.mit.edu	37	19	4793005	4793005	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr19:4793005G>A	uc002mbf.2	+	1	1278	c.1139G>A	c.(1138-1140)CGC>CAC	p.R380H	uc002mbg.1_RNA	NM_018708	NP_061178	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a	380					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		ATCCGGGAGCGCATCCTCGGT	0.617000												
ZNRF4	148066	broad.mit.edu	37	19	5456204	5456204	+	Silent	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr19:5456204G>A	uc002mca.3	+	1	779	c.702G>A	c.(700-702)GCG>GCA	p.A234A		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	234	Extracellular (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CGGCCCACGCGCTGCTCCTGC	0.682000												
PRAM1	84106	broad.mit.edu	37	19	8564247	8564247	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr19:8564247C>T	uc002mkd.2	-	2	465	c.445G>A	c.(445-447)GGT>AGT	p.G149S	PRAM1_uc002mkc.2_Missense_Mutation_p.G149S	NM_032152	NP_115528	Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	197	Pro-rich.						lipid binding|protein binding				0						GGGGCCTCACCGACCTCAGGC	0.662000												
ZNF177	7730	broad.mit.edu	37	19	9492250	9492250	+	Missense_Mutation	SNP	A	A	G			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr19:9492250A>G	uc002mli.2	+	12	1426	c.763A>G	c.(763-765)AAG>GAG	p.K255E	ZNF177_uc002mlj.2_Missense_Mutation_p.K205E|ZNF177_uc002mlk.2_Missense_Mutation_p.K255E	NM_003451	NP_003442	Q13360	ZN177_HUMAN	zinc finger protein 177	255	C2H2-type 5.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TATTGTGCACAAGAGAACTCA	0.468000												
CYP4F2	8529	broad.mit.edu	37	19	15989736	15989736	+	Missense_Mutation	SNP	C	C	T	rs146148233		TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr19:15989736C>T	uc002nbs.1	-	13	1458	c.1408G>A	c.(1408-1410)GGG>AGG	p.G470R	CYP4F2_uc010xot.1_Missense_Mutation_p.G321R	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	470					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						AACGTCTGCCCGATGCAGTTC	0.672000												
TSHZ3	57616	broad.mit.edu	37	19	31769496	31769496	+	Silent	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr19:31769496G>A	uc002nsy.3	-	2	1268	c.1203C>T	c.(1201-1203)CTC>CTT	p.L401L		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	401	C2H2-type 3; atypical.				negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TGTGGGCAGTGAGCTCCTGCA	0.557000												
ZNF529	57711	broad.mit.edu	37	19	37039085	37039085	+	Missense_Mutation	SNP	G	G	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr19:37039085G>T	uc002oeh.3	-	5	577	c.375C>A	c.(373-375)AGC>AGA	p.S125R	ZNF529_uc010xth.1_Missense_Mutation_p.S125R|ZNF529_uc010xti.1_Missense_Mutation_p.S107R|ZNF529_uc002oeg.3_Missense_Mutation_p.S20R	NM_020951	NP_066002	Q6P280	ZN529_HUMAN	zinc finger protein 529 isoform a	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)					TCTTGCTTTTGCTTTGCCAGT	0.373000												
ZNF229	7772	broad.mit.edu	37	19	44933774	44933774	+	Silent	SNP	G	G	C			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr19:44933774G>C	uc002oze.1	-	6	1616	c.1182C>G	c.(1180-1182)GTC>GTG	p.V394V	ZNF229_uc010ejk.1_Silent_p.V48V|ZNF229_uc010ejl.1_Silent_p.V388V	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	394	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				CCCTCTGATGGACAAGCAGGT	0.488000												
KLK1	3816	broad.mit.edu	37	19	51322566	51322566	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr19:51322566G>A	uc002ptk.1	-	5	712	c.673C>T	c.(673-675)CAA>TAA	p.Q225*	KLK1_uc010ycg.1_RNA	NM_002257	NP_002248	P06870	KLK1_HUMAN	kallikrein 1 preproprotein	225	Peptidase S1.				proteolysis	nucleus	serine-type endopeptidase activity				0		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTGACACCTTGGAGCACACCA	0.582000												
C19orf18	147685	broad.mit.edu	37	19	58472857	58472857	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr19:58472857G>A	uc002qqv.2	-	5	538	c.434C>T	c.(433-435)CCG>CTG	p.P145L		NM_152474	NP_689687	Q8NEA5	CS018_HUMAN	hypothetical protein LOC147685 precursor	145	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		TCCTAATAACGGTATCCTGAG	0.453000												
NFE2L2	4780	broad.mit.edu	37	2	178096690	178096690	+	Missense_Mutation	SNP	G	G	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr2:178096690G>T	uc002ulh.3	-	5	1196	c.641C>A	c.(640-642)CCA>CAA	p.P214Q	NFE2L2_uc002ulg.3_Missense_Mutation_p.P198Q|NFE2L2_uc010zfa.1_Missense_Mutation_p.P191Q|NFE2L2_uc002uli.3_Missense_Mutation_p.P198Q	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	214					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TTCTGGACTTGGAACCATGGT	0.338000			Mis		NSCLC|HNSCC					HNSCC(56;0.16)		
TTN	7273	broad.mit.edu	37	2	179426117	179426117	+	Missense_Mutation	SNP	G	G	C			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr2:179426117G>C	uc010zfg.1	-	275	77262	c.77038C>G	c.(77038-77040)CCT>GCT	p.P25680A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P19375A|TTN_uc010zfi.1_Missense_Mutation_p.P19308A|TTN_uc010zfj.1_Missense_Mutation_p.P19183A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26607							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTCTTGCAGGGACTGGTTCA	0.413000												
TTN	7273	broad.mit.edu	37	2	179581972	179581972	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr2:179581972G>A	uc010zfg.1	-	85	21981	c.21757C>T	c.(21757-21759)CGC>TGC	p.R7253C	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R3914C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8180							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCCAGGGCGAATCTCTCGG	0.458000												
PARD3B	117583	broad.mit.edu	37	2	205990415	205990415	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr2:205990415C>T	uc002var.1	+	10	1595	c.1388C>T	c.(1387-1389)TCG>TTG	p.S463L	PARD3B_uc010fub.1_Missense_Mutation_p.S463L|PARD3B_uc002vao.1_Missense_Mutation_p.S463L|PARD3B_uc002vap.1_Missense_Mutation_p.S463L|PARD3B_uc002vaq.1_Missense_Mutation_p.S463L	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	463	PDZ 2.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GAGACAGCATCGCTGGTCATT	0.488000												
SLC16A14	151473	broad.mit.edu	37	2	230910835	230910835	+	Missense_Mutation	SNP	T	T	C			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr2:230910835T>C	uc002vqd.1	-	4	1370	c.1007A>G	c.(1006-1008)CAC>CGC	p.H336R	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Missense_Mutation_p.H336R|SLC16A14_uc002vqf.2_Missense_Mutation_p.H336R	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	336	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TTCTGGGAGGTGAATGAAGGG	0.403000												
TOMM34	10953	broad.mit.edu	37	20	43572151	43572151	+	Silent	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr20:43572151C>T	uc002xmy.2	-	6	908	c.768G>A	c.(766-768)CTG>CTA	p.L256L	PABPC1L_uc002xmx.2_Intron|TOMM34_uc002xmz.2_RNA	NM_006809	NP_006800	Q15785	TOM34_HUMAN	translocase of outer mitochondrial membrane 34	256	TPR 5.				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	heat shock protein binding|signal sequence binding				0		Myeloproliferative disorder(115;0.0122)				TCTTTCCATCCAGCTTGAGGG	0.478000												
GRIK1	2897	broad.mit.edu	37	21	31045467	31045467	+	Missense_Mutation	SNP	C	C	G			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr21:31045467C>G	uc002yno.1	-	4	1026	c.562G>C	c.(562-564)GAG>CAG	p.E188Q	GRIK1_uc002ynn.2_Missense_Mutation_p.E188Q|GRIK1_uc011acs.1_Missense_Mutation_p.E188Q|GRIK1_uc011act.1_Missense_Mutation_p.E132Q|GRIK1_uc010glq.1_Missense_Mutation_p.E46Q|GRIK1_uc002ynr.2_Missense_Mutation_p.E188Q	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	188	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TTGATGAGCTCTTGTAGACGA	0.393000												
TPST2	8459	broad.mit.edu	37	22	26937013	26937013	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr22:26937013C>T	uc003acv.2	-	2	752	c.584G>A	c.(583-585)CGC>CAC	p.R195H	TPST2_uc003acw.2_Missense_Mutation_p.R195H|TPST2_uc003acx.2_Missense_Mutation_p.R195H|TPST2_uc011akf.1_Missense_Mutation_p.R195H	NM_003595	NP_003586	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	195	Lumenal (Potential).				peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)	1						GGTGACTTTGCGCGTGATCAT	0.602000												
PLXNB2	23654	broad.mit.edu	37	22	50715103	50715103	+	Silent	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr22:50715103C>T	uc003bkv.3	-	35	5398	c.5292G>A	c.(5290-5292)CAG>CAA	p.Q1764Q	PLXNB2_uc003bkt.1_Silent_p.Q556Q|PLXNB2_uc003bku.1_Silent_p.Q749Q	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1764	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGTCGCTGACCTGCACCATCT	0.622000												
TRANK1	9881	broad.mit.edu	37	3	36896947	36896947	+	Silent	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr3:36896947C>T	uc003cgj.2	-	3	2786	c.2484G>A	c.(2482-2484)TCG>TCA	p.S828S		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1378					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CCCTGAGCTTCGACAGCCTCC	0.493000												
PCBP4	57060	broad.mit.edu	37	3	51992845	51992845	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr3:51992845G>A	uc003dcd.1	-	11	1280	c.884C>T	c.(883-885)CCG>CTG	p.P295L	PCBP4_uc003dcb.1_Missense_Mutation_p.P261L|PCBP4_uc003dcc.1_Missense_Mutation_p.P316L|PCBP4_uc003dce.1_Silent_p.S296S|PCBP4_uc003dcf.1_Missense_Mutation_p.P295L|PCBP4_uc003dcg.1_Missense_Mutation_p.P261L|PCBP4_uc003dch.1_Missense_Mutation_p.P295L|PCBP4_uc003dci.1_Missense_Mutation_p.P135L|PCBP4_uc003dcj.1_Missense_Mutation_p.P295L|PCBP4_uc003dck.1_Missense_Mutation_p.P252L|PCBP4_uc003dcl.1_Missense_Mutation_p.P295L	NM_033010	NP_127503	P57723	PCBP4_HUMAN	poly(rC) binding protein 4 isoform c	295						cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GATGGAGACCGGAGAGCCAGT	0.627000												
KALRN	8997	broad.mit.edu	37	3	124436117	124436117	+	Missense_Mutation	SNP	A	A	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr3:124436117A>T	uc003ehg.2	+	59	8427	c.8300A>T	c.(8299-8301)GAC>GTC	p.D2767V	KALRN_uc003ehk.2_Missense_Mutation_p.D1070V	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2766	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CGGCTCTTAGACTACCTTATG	0.408000												
VEPH1	79674	broad.mit.edu	37	3	157188240	157188240	+	Missense_Mutation	SNP	C	C	T	rs141413130		TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr3:157188240C>T	uc003fbj.1	-	3	534	c.217G>A	c.(217-219)GAG>AAG	p.E73K	VEPH1_uc003fbk.1_Missense_Mutation_p.E73K|VEPH1_uc010hvu.1_Missense_Mutation_p.E73K|VEPH1_uc003fbm.2_Missense_Mutation_p.E73K|VEPH1_uc003fbn.2_Missense_Mutation_p.E73K	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	73						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TCAATGGACTCGGTCTCTCTG	0.458000												
SAMD7	344658	broad.mit.edu	37	3	169644391	169644391	+	Missense_Mutation	SNP	T	T	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr3:169644391T>A	uc003fgd.2	+	6	608	c.341T>A	c.(340-342)ATT>AAT	p.I114N	SAMD7_uc003fge.2_Missense_Mutation_p.I114N|SAMD7_uc011bpo.1_Missense_Mutation_p.I15N	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	114										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			ATGGAAAAAATTAATCCCAAG	0.453000												
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)		
DNAJB11	51726	broad.mit.edu	37	3	186299790	186299790	+	Silent	SNP	G	G	C			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr3:186299790G>C	uc003fqi.2	+	6	826	c.606G>C	c.(604-606)GTG>GTC	p.V202V		NM_016306	NP_057390	Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	202					protein folding	endoplasmic reticulum lumen	heat shock protein binding			ovary(1)|lung(1)	2	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		TCAGACTAGTGAATGAAGAAC	0.333000												
HNRNPD	3184	broad.mit.edu	37	4	83278030	83278030	+	Missense_Mutation	SNP	T	T	C			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr4:83278030T>C	uc003hmm.1	-	6	1090	c.772A>G	c.(772-774)ATG>GTG	p.M258V	HNRNPD_uc003hml.1_RNA|HNRNPD_uc003hmn.1_Missense_Mutation_p.M239V|HNRNPD_uc003hmo.1_Missense_Mutation_p.M258V|HNRNPD_uc003hmp.1_Missense_Mutation_p.M239V|HNRNPD_uc010ijr.1_Missense_Mutation_p.M239V|HNRNPD_uc011cci.1_Missense_Mutation_p.M104V	NM_031370	NP_112738	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D	258	RRM 2.				nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding				0						TCCTTCGACATGGCTACTTTT	0.373000												
CDS1	1040	broad.mit.edu	37	4	85553014	85553014	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr4:85553014G>A	uc011ccv.1	+	6	1121	c.623G>A	c.(622-624)CGT>CAT	p.R208H	CDS1_uc010ike.1_Missense_Mutation_p.R12H	NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	208					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		AAACATTATCGTCTGCAGTTT	0.328000												
TLL1	7092	broad.mit.edu	37	4	167012436	167012436	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr4:167012436C>T	uc003irh.1	+	19	3246	c.2599C>T	c.(2599-2601)CGG>TGG	p.R867W	TLL1_uc011cjn.1_Missense_Mutation_p.R890W|TLL1_uc011cjo.1_Missense_Mutation_p.R691W	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	867	CUB 4.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AATGTTTGTTCGGTTTGTTTC	0.403000												
PCDHA1	56147	broad.mit.edu	37	5	140166324	140166324	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr5:140166324C>T	uc003lhb.2	+	1	449	c.449C>T	c.(448-450)TCG>TTG	p.S150L	PCDHA1_uc003lha.2_Missense_Mutation_p.S150L|PCDHA1_uc003lgz.2_Missense_Mutation_p.S150L	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	150	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCTGAATTCGCGTTTTCCG	0.443000												
PCDHA6	56142	broad.mit.edu	37	5	140208285	140208285	+	Missense_Mutation	SNP	G	G	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr5:140208285G>T	uc003lho.2	+	1	636	c.609G>T	c.(607-609)GAG>GAT	p.E203D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.E203D|PCDHA6_uc011dab.1_Missense_Mutation_p.E203D	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	203	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACAGAGAGGAAGCTCCTG	0.448000												
PCDHA8	56140	broad.mit.edu	37	5	140222835	140222835	+	Silent	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr5:140222835G>A	uc003lhs.2	+	1	1929	c.1929G>A	c.(1927-1929)CCG>CCA	p.P643P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.P643P	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	643	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGACTCTCCGCGCCACCGTC	0.662000												
PCDHGB2	56103	broad.mit.edu	37	5	140741004	140741004	+	Silent	SNP	C	C	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr5:140741004C>A	uc003ljs.1	+	1	1302	c.1302C>A	c.(1300-1302)TCC>TCA	p.S434S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Silent_p.S434S|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	434	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTCTCCTCCAGCATAATTG	0.542000												
NR3C1	2908	broad.mit.edu	37	5	142779330	142779330	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr5:142779330C>T	uc003lmz.2	-	2	1567	c.1075G>A	c.(1075-1077)GTT>ATT	p.V359I	NR3C1_uc003lmy.2_Missense_Mutation_p.V359I|NR3C1_uc003lna.2_Missense_Mutation_p.V359I|NR3C1_uc003lnb.2_Missense_Mutation_p.V359I|NR3C1_uc011dbk.1_Intron|NR3C1_uc003lnc.2_Missense_Mutation_p.V359I|NR3C1_uc003lnd.2_Missense_Mutation_p.V359I|NR3C1_uc003lne.2_Missense_Mutation_p.V359I|NR3C1_uc003lnf.2_Missense_Mutation_p.V359I|NR3C1_uc003lng.2_Missense_Mutation_p.V359I|NR3C1_uc003lnh.2_Missense_Mutation_p.V359I|NR3C1_uc003lni.2_Missense_Mutation_p.V359I	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	359	Modulating.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	TCGGAACCAACGGGAATTGGT	0.443000												
GRIA1	2890	broad.mit.edu	37	5	153149797	153149797	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr5:153149797C>T	uc003lva.3	+	13	2457	c.2092C>T	c.(2092-2094)CGG>TGG	p.R698W	GRIA1_uc003luy.3_Missense_Mutation_p.R698W|GRIA1_uc003luz.3_Missense_Mutation_p.R603W|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.R618W|GRIA1_uc011dcx.1_Missense_Mutation_p.R629W|GRIA1_uc011dcy.1_Missense_Mutation_p.R708W|GRIA1_uc011dcz.1_Missense_Mutation_p.R708W	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	698	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGTTTTTGTGCGGACCACAGA	0.463000												
POLH	5429	broad.mit.edu	37	6	43581728	43581728	+	Missense_Mutation	SNP	A	A	G			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr6:43581728A>G	uc003ovq.3	+	11	1880	c.1576A>G	c.(1576-1578)ACA>GCA	p.T526A	POLH_uc010jyu.2_Missense_Mutation_p.T402A|POLH_uc011dvl.1_RNA|POLH_uc003ovr.3_Missense_Mutation_p.T427A	NM_006502	NP_006493	Q9Y253	POLH_HUMAN	DNA-directed DNA polymerase eta	526					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(2)	2	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			CAGTCAAAGTACAGGAACTGA	0.433000								DNA_polymerases_(catalytic_subunits)	Xeroderma_Pigmentosum			
MUT	4594	broad.mit.edu	37	6	49415470	49415470	+	Silent	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr6:49415470C>T	uc003ozg.3	-	8	1728	c.1473G>A	c.(1471-1473)AAG>AAA	p.K491K		NM_000255	NP_000246	P22033	MUTA_HUMAN	methylmalonyl Coenzyme A mutase precursor	491					fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCAACTGGTACTTATTTACTC	0.318000												
KCNQ5	56479	broad.mit.edu	37	6	73904416	73904416	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr6:73904416C>T	uc003pgk.2	+	14	2425	c.2078C>T	c.(2077-2079)ACG>ATG	p.T693M	KCNQ5_uc011dyh.1_Missense_Mutation_p.T712M|KCNQ5_uc011dyi.1_Missense_Mutation_p.T703M|KCNQ5_uc010kat.2_Missense_Mutation_p.T684M|KCNQ5_uc011dyj.1_Missense_Mutation_p.T583M|KCNQ5_uc011dyk.1_Missense_Mutation_p.T443M	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	693					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TTCATTCTGACGCCAAATGAG	0.502000												
COL12A1	1303	broad.mit.edu	37	6	75838110	75838110	+	Missense_Mutation	SNP	A	A	G			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr6:75838110A>G	uc003phs.2	-	38	6408	c.6242T>C	c.(6241-6243)ATA>ACA	p.I2081T	COL12A1_uc003pht.2_Missense_Mutation_p.I917T	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2081	Fibronectin type-III 16.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GGGCTGCAGTATTACATTGTT	0.378000												
SYNE1	23345	broad.mit.edu	37	6	152673313	152673313	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr6:152673313G>A	uc010kiw.2	-	70	12031	c.11429C>T	c.(11428-11430)ACG>ATG	p.T3810M	SYNE1_uc003qot.3_Missense_Mutation_p.T3795M|SYNE1_uc003qou.3_Missense_Mutation_p.T3810M|SYNE1_uc010kja.1_Missense_Mutation_p.T515M	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3810	Cytoplasmic (Potential).|Potential.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTTTTCCAGCGTCATGTGTTC	0.438000										HNSCC(10;0.0054)		
MACC1	346389	broad.mit.edu	37	7	20198241	20198241	+	Silent	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr7:20198241G>A	uc003sus.3	-	5	2052	c.1743C>T	c.(1741-1743)CTC>CTT	p.L581L	MACC1_uc010kug.2_Silent_p.L581L	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	581	SH3.				positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						TACCTTCCCCGAGGAGAGCTA	0.418000												
RAMP3	10268	broad.mit.edu	37	7	45222946	45222946	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr7:45222946G>A	uc003tnb.2	+	3	443	c.382G>A	c.(382-384)GTT>ATT	p.V128I	RAMP3_uc003tnc.2_Missense_Mutation_p.V96I	NM_005856	NP_005847	O60896	RAMP3_HUMAN	receptor activity modifying protein 3 precursor	128	Helical; (Potential).				intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane|lysosome	protein transporter activity				0					Pramlintide(DB01278)	TATACCCGTCGTTCTGACTGT	0.622000												
TMEM130	222865	broad.mit.edu	37	7	98460898	98460898	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr7:98460898G>A	uc003upo.2	-	2	400	c.211C>T	c.(211-213)CGC>TGC	p.R71C	TMEM130_uc011kiq.1_Missense_Mutation_p.R52C|TMEM130_uc011kir.1_Missense_Mutation_p.R71C|TMEM130_uc003upn.2_Intron	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	71	Extracellular (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CAGTGGAAGCGGTAGAGGTGG	0.667000												
ADAM18	8749	broad.mit.edu	37	8	39587447	39587447	+	Silent	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr8:39587447C>T	uc003xni.2	+	20	2208	c.2208C>T	c.(2206-2208)GAC>GAT	p.D736D	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Silent_p.D712D	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	736	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			AAAGCGATGACGTGGGACATT	0.323000												
RIMS2	9699	broad.mit.edu	37	8	104898187	104898187	+	Silent	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr8:104898187C>T	uc003yls.2	+	2	935	c.694C>T	c.(694-696)CTA>TTA	p.L232L	RIMS2_uc003ylp.2_Silent_p.L454L|RIMS2_uc003ylw.2_Silent_p.L262L|RIMS2_uc003ylq.2_Silent_p.L262L|RIMS2_uc003ylr.2_Silent_p.L262L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	485					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TACTGACTCACTACGGAAACA	0.448000										HNSCC(12;0.0054)		
RNF139	11236	broad.mit.edu	37	8	125499249	125499249	+	Silent	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr8:125499249C>T	uc003yrc.2	+	2	1702	c.1359C>T	c.(1357-1359)CTC>CTT	p.L453L		NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	453					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			ATAATGTCCTCTGGGAAAAGC	0.353000									Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3			
KIAA1432	57589	broad.mit.edu	37	9	5772699	5772699	+	Missense_Mutation	SNP	A	A	G			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr9:5772699A>G	uc003zji.2	+	23	3608	c.3515A>G	c.(3514-3516)GAG>GGG	p.E1172G	KIAA1432_uc003zjl.3_Missense_Mutation_p.E1135G|ERMP1_uc011lme.1_Intron	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	1251						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		ATTTCCATGGAGTTGGCCAGT	0.453000												
KIAA1797	54914	broad.mit.edu	37	9	20952989	20952989	+	Missense_Mutation	SNP	A	A	G			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr9:20952989A>G	uc003zog.1	+	37	4420	c.4057A>G	c.(4057-4059)ACT>GCT	p.T1353A	KIAA1797_uc003zoh.1_Missense_Mutation_p.T789A	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1353						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		CACAGTTCCTACTGACTATAG	0.393000												
C9orf103	414328	broad.mit.edu	37	9	86258434	86258434	+	Silent	SNP	A	A	C			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr9:86258434A>C	uc004amu.1	+	5	317	c.303A>C	c.(301-303)GTA>GTC	p.V101V	C9orf103_uc004amt.1_Silent_p.V55V|C9orf103_uc010mpv.1_Silent_p.V55V	NM_001001551	NP_001001551	Q5T6J7	GNTK_HUMAN	gluconokinase-like protein	101					carbohydrate metabolic process	cytoplasm	ATP binding|gluconokinase activity|shikimate kinase activity				0						AAGATGGTGTAGCTCTGAAGT	0.507000												
FAM78A	286336	broad.mit.edu	37	9	134151258	134151258	+	Silent	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr9:134151258G>A	uc004cak.2	-	1	649	c.309C>T	c.(307-309)TAC>TAT	p.Y103Y		NM_033387	NP_203745	Q5JUQ0	FA78A_HUMAN	hypothetical protein LOC286336	103										ovary(1)	1	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)		CCTGCTCGCCGTACTGGTTGT	0.652000												
CXorf23	256643	broad.mit.edu	37	X	19973635	19973635	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chrX:19973635C>T	uc004czp.2	-	4	1324	c.1324G>A	c.(1324-1326)GCT>ACT	p.A442T	CXorf23_uc010nfn.2_RNA|CXorf23_uc011mjg.1_Missense_Mutation_p.A7T|CXorf23_uc004czo.2_Missense_Mutation_p.A392T	NM_198279	NP_938020	A2AJT9	CX023_HUMAN	hypothetical protein LOC256643	442						mitochondrion				lung(1)|skin(1)	2						CTGCCAACAGCAACCAAATCA	0.363000												
FAM47B	170062	broad.mit.edu	37	X	34961131	34961131	+	Silent	SNP	C	C	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chrX:34961131C>A	uc004ddi.1	+	1	201	c.183C>A	c.(181-183)GCC>GCA	p.A61A		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	61										ovary(3)|breast(1)	4						TCCGCTACGCCTGTCAGTCTC	0.552000												
HUWE1	10075	broad.mit.edu	37	X	53655786	53655786	+	Missense_Mutation	SNP	C	C	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chrX:53655786C>A	uc004dsp.2	-	14	1433	c.1031G>T	c.(1030-1032)AGC>ATC	p.S344I		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	344					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AATAATACTGCTGAGTTTGGG	0.393000												
KIAA2022	340533	broad.mit.edu	37	X	73962731	73962731	+	Missense_Mutation	SNP	A	A	C			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chrX:73962731A>C	uc004eby.2	-	3	2278	c.1661T>G	c.(1660-1662)ATG>AGG	p.M554R		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	554					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CTTCACCAGCATGTTCTTCTC	0.423000												
CENPI	2491	broad.mit.edu	37	X	100417865	100417865	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chrX:100417865G>A	uc004egx.2	+	21	2450	c.2180G>A	c.(2179-2181)GGG>GAG	p.G727E	CENPI_uc011mrg.1_Missense_Mutation_p.G713E	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	727					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						TTTTCACAGGGGTTACAAGGC	0.343000												
ZMAT1	84460	broad.mit.edu	37	X	101139539	101139539	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chrX:101139539G>A	uc004eim.2	-	2	3845	c.347C>T	c.(346-348)TCA>TTA	p.S116L	ZMAT1_uc011mrl.1_Missense_Mutation_p.S287L|ZMAT1_uc004ein.2_Missense_Mutation_p.S116L|ZMAT1_uc011mrm.1_Missense_Mutation_p.S116L	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	116						nucleus	zinc ion binding			ovary(1)	1						CATTGCTTGTGAAATATTGTA	0.398000												
TCEAL5	340543	broad.mit.edu	37	X	102529130	102529130	+	Missense_Mutation	SNP	T	T	G			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chrX:102529130T>G	uc004ejz.1	-	3	657	c.362A>C	c.(361-363)GAC>GCC	p.D121A		NM_001012979	NP_001012997	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(1)|breast(1)	2						CGTCCCCCTGTCGGTTTTTCT	0.577000												
NRK	203447	broad.mit.edu	37	X	105179181	105179181	+	Silent	SNP	A	A	G			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chrX:105179181A>G	uc004emd.2	+	21	3822	c.3519A>G	c.(3517-3519)GAA>GAG	p.E1173E	NRK_uc010npc.1_Silent_p.E841E	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1173							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GATTCGTAGAAGTACCTGAGG	0.378000										HNSCC(51;0.14)		
ACTRT1	139741	broad.mit.edu	37	X	127185408	127185408	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chrX:127185408C>A	uc004eum.2	-	1	975	c.778G>T	c.(778-780)GAG>TAG	p.E260*		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	260						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						AAAAGAACCTCGGGCACTTGG	0.527000												
UHRF1BP1	54887	broad.mit.edu	37	6	34827350	34827351	+	Splice_Site	INS	-	-	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr6:34827349_34827350G>GT	uc003oju.4	+	14	3449	c.3215_splice	c.e14+1	p.K1072_splice	UHRF1BP1_uc010jvm.2_Splice_Site|UHRF1BP1_uc010jvn.3_Splice_Site|UHRF1BP1_uc010jvo.3_Splice_Site	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	Homo sapiens UHRF1 binding protein 1 (UHRF1BP1), mRNA.	1072										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						CCCCAGCCAAGTAAGTGGCTCT	0.490												
ANKRD55	79722	broad.mit.edu	37	5	55407173	55407173	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr5:55407172_55407172TG>T	uc003jqu.3	-	9	1555	c.1403_1403CA>A	c.(1402-1404)cagfs	p.Q468fs	ANKRD55_uc003jqt.3_Frame_Shift_Del_p.Q180fs	NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	Homo sapiens ankyrin repeat domain 55 (ANKRD55), mRNA.	467										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(1)	34		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				CTGAGATCGCTGGGCCATATG	0.493												
UHRF1BP1	54887	broad.mit.edu	37	6	34827350	34827351	+	Splice_Site	INS	-	-	T			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr6:34827349_34827350G>GT	uc003oju.4	+	14	3449	c.3215_splice	c.e14+1	p.K1072_splice	UHRF1BP1_uc010jvm.2_Splice_Site|UHRF1BP1_uc010jvn.3_Splice_Site|UHRF1BP1_uc010jvo.3_Splice_Site	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	Homo sapiens UHRF1 binding protein 1 (UHRF1BP1), mRNA.	1072										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						CCCCAGCCAAGTAAGTGGCTCT	0.490												
NF1	4763	broad.mit.edu	37	17	29556080	29556085	+	In_Frame_Del	DEL	GAATGT	GAATGT	-			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr17:29556079_29556084CGAATGT>C	uc002hgg.3	+	20	2829_2834	c.2446_2451CGAATGT>C	c.(2446-2451)cgaatg>C	p.RM816del	NF1_uc002hgh.3_In_Frame_Del_p.RM816del|NF1_uc010csn.2_In_Frame_Del_p.RM676del|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	Homo sapiens neurofibromin 1 (NF1), transcript variant 1, mRNA.	816					MAPKKK cascade|Ras protein signal transduction|actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|metanephros development|myelination in peripheral nervous system|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	Ras GTPase activator activity|protein binding	p.R816*(8)|p.0?(8)|p.?(4)|p.R815fs*6(1)|p.S818fs*13(1)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGTTAAGAGGCGAATGTCCCATGTGA	0.427			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)		
TUBD1	51174	broad.mit.edu	37	17	57968199	57968201	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-CG-5722-01A-21D-1600-08	TCGA-CG-5722-11A-02D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78d7b4b4-4d1b-42a3-9051-3b84a0b371c4	f209e9fe-c3db-4fe3-bc2f-2f92cee6a331	g.chr17:57968198_57968200TCTC>T	uc002ixw.2	-	1	452_454	c.164_166GAGA>A	c.(163-168)gagaat>gAat	p.N56del	TUBD1_uc010wok.2_In_Frame_Del_p.N56del|TUBD1_uc010ddf.2_In_Frame_Del_p.N56del|TUBD1_uc010wol.2_Intron|TUBD1_uc010ddg.2_In_Frame_Del_p.N21del|TUBD1_uc010ddi.2_In_Frame_Del_p.N56del|TUBD1_uc010ddh.2_5'UTR|TUBD1_uc002ixx.2_In_Frame_Del_p.N56del|RPS6KB1_uc010ddj.2_5'Flank|RPS6KB1_uc002ixy.3_5'Flank|RPS6KB1_uc010wom.2_5'Flank|RPS6KB1_uc010won.2_5'Flank	NM_016261	NP_001180542	Q9UJT1	TBD_HUMAN	Homo sapiens tubulin, delta 1 (TUBD1), transcript variant 1, mRNA.	56					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			NS(2)|breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(2)	21	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			CTACCTCCATTCTCCTCCTCACT	0.483