Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
NADK	65220	broad.mit.edu	37	1	1696699	1696699	+	Silent	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:1696699G>C	uc009vkw.2	-	2	268	c.147C>G	c.(145-147)GCC>GCG	p.A49A	NADK_uc001aic.2_Silent_p.A49A|NADK_uc001aid.3_Silent_p.A49A|NADK_uc001aie.2_Silent_p.A49A|NADK_uc009vkx.1_5'UTR	NM_023018	NP_075394	O95544	NADK_HUMAN	NAD kinase	49					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		GGGCGGGCGAGGCAGACAGGC	0.567												
C1orf127	148345	broad.mit.edu	37	1	11008300	11008300	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:11008300C>G	uc010oao.1	-	8	1450	c.1445G>C	c.(1444-1446)GGT>GCT	p.G482A	C1orf127_uc001arr.1_Missense_Mutation_p.G464A|C1orf127_uc001ars.1_Missense_Mutation_p.G456A	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345	482										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		CCTGGGGAGACCAGGCCCTGT	0.642												
FBXO44	93611	broad.mit.edu	37	1	11721234	11721234	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:11721234G>A	uc001asm.2	+	6	798	c.672G>A	c.(670-672)TGG>TGA	p.W224*	FBXO44_uc001ask.2_Missense_Mutation_p.V183I|FBXO44_uc001asl.2_Nonsense_Mutation_p.W224*|FBXO44_uc001asn.2_Missense_Mutation_p.V183I|FBXO44_uc010oar.1_Missense_Mutation_p.V215I|FBXO44_uc010oas.1_Nonsense_Mutation_p.W84*|FBXO6_uc001aso.2_5'Flank	NM_033182	NP_149438	Q9H4M3	FBX44_HUMAN	F-box protein 44 isoform 1	224	FBA.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		GCTACATCTGGTTTCAGCACG	0.627												
NECAP2	55707	broad.mit.edu	37	1	16775642	16775642	+	Silent	SNP	C	C	A	rs143289277	byFrequency	TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:16775642C>A	uc001ayo.2	+	5	525	c.435C>A	c.(433-435)GGC>GGA	p.G145G	NECAP2_uc001ayp.3_RNA|NECAP2_uc010ocd.1_Silent_p.G119G|NECAP2_uc001ayq.2_Silent_p.G145G	NM_018090	NP_060560	Q9NVZ3	NECP2_HUMAN	NECAP endocytosis associated 2 isoform 1	145					endocytosis|protein transport	clathrin vesicle coat|coated pit|plasma membrane					0		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|Kidney(64;0.000181)|KIRC - Kidney renal clear cell carcinoma(64;0.00268)|STAD - Stomach adenocarcinoma(196;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		CAGACCAAGGCCCTAAACTGG	0.532												
PLA2G2E	30814	broad.mit.edu	37	1	20249208	20249208	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:20249208C>A	uc001bct.1	-	2	139	c.81G>T	c.(79-81)ATG>ATT	p.M27I		NM_014589	NP_055404	Q9NZK7	PA2GE_HUMAN	phospholipase A2, group IIE precursor	27					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity				0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|GBM - Glioblastoma multiforme(114;0.000146)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TCTTCTCGATCATCACCCCAA	0.527												
PINK1	65018	broad.mit.edu	37	1	20964478	20964478	+	Silent	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:20964478A>G	uc001bdm.2	+	2	625	c.531A>G	c.(529-531)ACA>ACG	p.T177T		NM_032409	NP_115785	Q9BXM7	PINK1_HUMAN	PTEN induced putative kinase 1 precursor	177	Protein kinase.|Cytoplasmic (Potential).				cell death|intracellular protein kinase cascade|mitochondrion degradation|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of release of cytochrome c from mitochondria|regulation of protein complex assembly|regulation of protein ubiquitination|response to stress	cytosol|integral to membrane|mitochondrial outer membrane	ATP binding|C3HC4-type RING finger domain binding|calcium-dependent protein kinase activity|magnesium ion binding|protein serine/threonine kinase activity|ubiquitin protein ligase binding			ovary(2)|central_nervous_system(1)	3		all_lung(284;2.72e-05)|Lung NSC(340;2.94e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.21e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000146)|Kidney(64;0.000182)|GBM - Glioblastoma multiforme(114;0.000497)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CCATGCCTACATTGCCCCAGA	0.602												
LAPTM5	7805	broad.mit.edu	37	1	31214496	31214496	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:31214496G>A	uc001bsc.2	-	3	340	c.249C>T	c.(247-249)GGC>GGT	p.G83G		NM_006762	NP_006753	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	83	Helical; (Potential).				transport	integral to plasma membrane|lysosomal membrane					0		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		CCTTGACTACGCCGATCAGTA	0.607												
CSMD2	114784	broad.mit.edu	37	1	34238273	34238273	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:34238273G>A	uc001bxn.1	-	13	1652	c.1623C>T	c.(1621-1623)GAC>GAT	p.D541D	CSMD2_uc001bxm.1_Silent_p.D581D	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	541	Sushi 3.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACTTGAGTGTGTCACCGTGGT	0.557												
CSF3R	1441	broad.mit.edu	37	1	36938265	36938265	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:36938265C>T	uc001caw.1	-	7	874	c.696G>A	c.(694-696)CTG>CTA	p.L232L	CSF3R_uc001cat.1_5'Flank|CSF3R_uc009vvc.1_5'Flank|CSF3R_uc001cau.1_5'Flank|CSF3R_uc001cav.1_Silent_p.L232L|CSF3R_uc001cax.1_Silent_p.L232L|CSF3R_uc001cay.1_Silent_p.L232L	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	232	Extracellular (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CCATGGTCCGCAGCATGGGGG	0.627												
EPHA10	284656	broad.mit.edu	37	1	38197083	38197083	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:38197083C>T	uc009vvi.2	-	7	1749	c.1663G>A	c.(1663-1665)GCT>ACT	p.A555T	EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	555	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CACTACTTACCCTCCCCCAGG	0.577												
COL9A2	1298	broad.mit.edu	37	1	40768858	40768858	+	Splice_Site	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:40768858C>G	uc001cfh.1	-	29	1619	c.1549_splice	c.e29-1	p.G517_splice	COL9A2_uc001cfi.1_Splice_Site_p.G336_splice	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor						axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			CATCCCGGCCCTGAAAGCAGA	0.627												
COL9A2	1298	broad.mit.edu	37	1	40770188	40770188	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:40770188T>C	uc001cfh.1	-	23	1245	c.1175A>G	c.(1174-1176)GAG>GGG	p.E392G	COL9A2_uc001cfi.1_Missense_Mutation_p.E211G	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	392	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			TGGACCCCTCTCGCCTTGGTC	0.617												
C1orf87	127795	broad.mit.edu	37	1	60456444	60456444	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:60456444C>T	uc001czs.1	-	12	1634	c.1542G>A	c.(1540-1542)CTG>CTA	p.L514L	C1orf87_uc001czr.1_Silent_p.L106L	NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	514							calcium ion binding			ovary(1)|breast(1)	2						GGCTCAGGGACAGGTTGTAAA	0.483												
DNAJC6	9829	broad.mit.edu	37	1	65858259	65858259	+	Silent	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:65858259C>A	uc001dcd.1	+	12	1607	c.1443C>A	c.(1441-1443)CCC>CCA	p.P481P	DNAJC6_uc001dcc.1_Silent_p.P512P|DNAJC6_uc010opc.1_Silent_p.P468P|DNAJC6_uc001dce.1_Silent_p.P538P	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	481	Pro-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						TCAAGAAGCCCAGCAAAAAGC	0.532												
AKNAD1	254268	broad.mit.edu	37	1	109395133	109395133	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:109395133C>G	uc001dwa.2	-	2	423	c.154G>C	c.(154-156)GAT>CAT	p.D52H	AKNAD1_uc010ovb.1_Intron|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	52										ovary(3)	3						TGAGGGTCATCTGCTATGAAA	0.383												
SYT6	148281	broad.mit.edu	37	1	114641809	114641809	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:114641809A>C	uc001eev.2	-	5	1266	c.1016T>G	c.(1015-1017)CTC>CGC	p.L339R	SYT6_uc001eeu.2_5'UTR	NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	424	Cytoplasmic (Potential).|C2 2.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GACAGGATTGAGAGTGTTTTT	0.463												
PRUNE	58497	broad.mit.edu	37	1	151006687	151006687	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:151006687A>C	uc001ewh.1	+	8	1475	c.1339A>C	c.(1339-1341)ACA>CCA	p.T447P	PRUNE_uc001ewi.1_Missense_Mutation_p.T265P|PRUNE_uc010pco.1_Missense_Mutation_p.T215P|PRUNE_uc001ewj.1_Missense_Mutation_p.T162P|PRUNE_uc001ewk.1_Missense_Mutation_p.T212P|BNIPL_uc009wmi.2_5'Flank|BNIPL_uc001ewl.2_5'Flank	NM_021222	NP_067045	Q86TP1	PRUNE_HUMAN	prune	447						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ACAGTCTACCACAGCCTCCCT	0.522												
CDC42SE1	56882	broad.mit.edu	37	1	151026763	151026763	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:151026763C>A	uc001ewo.2	-	5	770	c.200G>T	c.(199-201)GGA>GTA	p.G67V	CDC42SE1_uc001ewp.2_Missense_Mutation_p.G67V	NM_001038707	NP_001033796	Q9NRR8	C42S1_HUMAN	CDC42 small effector 1	67					phagocytosis|regulation of cell shape|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase inhibitor activity				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ATCTCGGTTTCCCTTGGATCT	0.448												
RFX5	5993	broad.mit.edu	37	1	151314729	151314729	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:151314729A>T	uc001exv.1	-	11	1998	c.1784T>A	c.(1783-1785)TTA>TAA	p.L595*	RFX5_uc001exw.1_Nonsense_Mutation_p.L595*|RFX5_uc009wmr.1_Nonsense_Mutation_p.L595*|RFX5_uc010pcx.1_Nonsense_Mutation_p.L555*	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	595						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ATGCTCCTTTAAGTCTTTATT	0.473												
SNX27	81609	broad.mit.edu	37	1	151634671	151634671	+	Silent	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:151634671G>C	uc001eyn.1	+	5	847	c.831G>C	c.(829-831)CTG>CTC	p.L277L	SNX27_uc001eyo.2_Silent_p.L184L|SNX27_uc001eyp.2_Silent_p.L91L	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	277	Ras-associating.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACGTAGAGCTGAGAGTAGCAT	0.403												
TCHHL1	126637	broad.mit.edu	37	1	152059360	152059360	+	Silent	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:152059360T>C	uc001ezo.1	-	3	863	c.798A>G	c.(796-798)AAA>AAG	p.K266K		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	266							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GTGTTGCTTCTTTTGGTGGTG	0.428												
TCHH	7062	broad.mit.edu	37	1	152086500	152086500	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:152086500G>A	uc001ezp.2	-	1	57	c.57C>T	c.(55-57)GTC>GTT	p.V19V	TCHH_uc009wne.1_Silent_p.V19V	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	19	S-100-like.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AATCATGAGAGACATACTGAT	0.368												
KPRP	448834	broad.mit.edu	37	1	152733487	152733487	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:152733487C>T	uc001fal.1	+	2	1481	c.1423C>T	c.(1423-1425)CGA>TGA	p.R475*		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	475	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCTTGTCCACGACCAGAGCC	0.672												
RUSC1	23623	broad.mit.edu	37	1	155297948	155297948	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:155297948T>C	uc001fkj.2	+	9	2651	c.2422T>C	c.(2422-2424)TCT>CCT	p.S808P	RAG1AP1_uc010pey.1_Intron|RUSC1_uc001fkk.2_Missense_Mutation_p.S702P|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_Missense_Mutation_p.S339P|RUSC1_uc001fkl.2_Missense_Mutation_p.S398P|RUSC1_uc001fkp.2_Missense_Mutation_p.S339P|RUSC1_uc001fkq.2_Missense_Mutation_p.S233P|RUSC1_uc010pgb.1_Missense_Mutation_p.S306P|RUSC1_uc009wqp.1_Missense_Mutation_p.S333P|RUSC1_uc001fkn.2_Missense_Mutation_p.S117P|RUSC1_uc001fko.2_RNA|RUSC1_uc001fkr.2_Missense_Mutation_p.S339P|RUSC1_uc001fks.2_Intron	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	808						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			TAGGAGACCATCTAGCTGGCT	0.587												
OR10K2	391107	broad.mit.edu	37	1	158390537	158390537	+	Silent	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:158390537G>T	uc010pii.1	-	1	120	c.120C>A	c.(118-120)GGC>GGA	p.G40G		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TTGCATTGGTGCCCAGAGTGA	0.517												
OR6K2	81448	broad.mit.edu	37	1	158669861	158669861	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:158669861G>A	uc001fsu.1	-	1	582	c.582C>T	c.(580-582)ATC>ATT	p.I194I		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					GAATCATGACGATGGCTCGTG	0.468												
MNDA	4332	broad.mit.edu	37	1	158813857	158813857	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:158813857A>T	uc001fsz.1	+	4	715	c.515A>T	c.(514-516)CAT>CTT	p.H172L		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	172					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					GCTGTGGATCATCCCCCACTA	0.498												
LY9	4063	broad.mit.edu	37	1	160786398	160786398	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:160786398C>G	uc001fwu.2	+	5	1137	c.1087C>G	c.(1087-1089)CCC>GCC	p.P363A	LY9_uc001fwv.2_Missense_Mutation_p.P363A|LY9_uc001fww.2_Intron|LY9_uc001fwx.2_Intron|LY9_uc001fwy.1_Intron|LY9_uc001fwz.2_Missense_Mutation_p.P15A	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	363	Extracellular (Potential).|Ig-like V-type 2.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GCTGAGGAAGCCCAAAATCAC	0.542												
RGS4	5999	broad.mit.edu	37	1	163044202	163044202	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:163044202T>C	uc009wuy.2	+	5	981	c.470T>C	c.(469-471)TTC>TCC	p.F157S	RGS4_uc001gcl.3_Missense_Mutation_p.F254S|RGS4_uc009wuz.2_3'UTR|RGS4_uc009wva.2_Missense_Mutation_p.F139S	NM_005613	NP_005604	P49798	RGS4_HUMAN	regulator of G-protein signaling 4 isoform 2	157	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(2)|central_nervous_system(1)	3						AAGAAGATTTTCAACCTGATG	0.507												
POGK	57645	broad.mit.edu	37	1	166818400	166818400	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:166818400G>T	uc001gdt.1	+	5	704	c.584G>T	c.(583-585)GGC>GTC	p.G195V	POGK_uc010ple.1_Missense_Mutation_p.G110V|POGK_uc010plf.1_Missense_Mutation_p.G77V	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	195					multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						TTCAGCCGGGGCATGCGCCGC	0.557												
SELP	6403	broad.mit.edu	37	1	169559386	169559386	+	Nonstop_Mutation	SNP	T	T	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:169559386T>G	uc001ggi.3	-	16	2558	c.2493A>C	c.(2491-2493)TAA>TAC	p.*831Y	SELP_uc001ggh.2_Nonstop_Mutation_p.*626Y|SELP_uc009wvr.2_Nonstop_Mutation_p.*830Y	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	831					platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	GGATCTTACCTTAAGGACTCG	0.333												
SELP	6403	broad.mit.edu	37	1	169559420	169559420	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:169559420A>C	uc001ggi.3	-	16	2524	c.2459T>G	c.(2458-2460)GTT>GGT	p.V820G	SELP_uc001ggh.2_Missense_Mutation_p.V615G|SELP_uc009wvr.2_Missense_Mutation_p.V819G	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	820	Endocytosis signal (Probable).|Cytoplasmic (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	GTTTGTAAAAACTCCATATGT	0.373												
BAT2L2	23215	broad.mit.edu	37	1	171484978	171484978	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:171484978G>A	uc010pmg.1	+	5	766	c.500G>A	c.(499-501)GGA>GAA	p.G167E	BAT2L2_uc001ghq.1_Missense_Mutation_p.G164E|BAT2L2_uc001ghr.1_Missense_Mutation_p.G169E	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	167							protein C-terminus binding				0						TATGGACCTGGACCCAGTTTA	0.403												
LGR6	59352	broad.mit.edu	37	1	202287851	202287851	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:202287851C>A	uc001gxu.2	+	18	2420	c.2420C>A	c.(2419-2421)GCC>GAC	p.A807D	LGR6_uc001gxv.2_Missense_Mutation_p.A755D|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Missense_Mutation_p.A668D	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	807	Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						ACGCCCGAGGCCGTCAAGTCT	0.647												
DSTYK	25778	broad.mit.edu	37	1	205156872	205156872	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:205156872A>C	uc001hbw.2	-	2	392	c.328T>G	c.(328-330)TGC>GGC	p.C110G	DSTYK_uc001hbx.2_Missense_Mutation_p.C110G	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	receptor interacting protein kinase 5 isoform 1	110						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1						CAAGGGAGGCAGTCCACAATC	0.468												
DTL	51514	broad.mit.edu	37	1	212238293	212238293	+	Silent	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:212238293A>G	uc009xdc.2	+	7	875	c.561A>G	c.(559-561)GGA>GGG	p.G187G	DTL_uc010ptb.1_Silent_p.G145G|DTL_uc001hiz.3_5'UTR	NM_016448	NP_057532	Q9NZJ0	DTL_HUMAN	denticleless homolog	187					DNA replication|G2/M transition DNA damage checkpoint|protein monoubiquitination|protein polyubiquitination|response to UV|translesion synthesis|ubiquitin-dependent protein catabolic process	centrosome|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|nuclear membrane	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00796)|all cancers(67;0.0385)|Epithelial(68;0.102)		AAATCAGTGGAGCTCACAATA	0.368												
CABC1	56997	broad.mit.edu	37	1	227174341	227174341	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:227174341C>G	uc001hqm.1	+	20	5266	c.1847C>G	c.(1846-1848)TCC>TGC	p.S616C	CABC1_uc001hqn.1_Missense_Mutation_p.S616C|CABC1_uc009xeq.1_Missense_Mutation_p.S564C|CABC1_uc010pvq.1_Missense_Mutation_p.S337C|CABC1_uc010pvr.1_Missense_Mutation_p.S290C|CABC1_uc001hqo.1_Missense_Mutation_p.S337C|CABC1_uc009xer.1_Missense_Mutation_p.S132C	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	616					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				ATGGGGGGCTCCTTCCTCATC	0.612												
PCNXL2	80003	broad.mit.edu	37	1	233136182	233136182	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:233136182G>T	uc001hvl.2	-	30	5432	c.5197C>A	c.(5197-5199)CCG>ACG	p.P1733T	PCNXL2_uc001hvk.1_Missense_Mutation_p.P385T|PCNXL2_uc001hvm.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1733						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				CGCCAGGCCGGGTCGCCCTCG	0.617												
MTR	4548	broad.mit.edu	37	1	237026804	237026804	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:237026804C>T	uc001hyi.3	+	22	2778	c.2355C>T	c.(2353-2355)CAC>CAT	p.H785H	MTR_uc010pxw.1_Silent_p.H378H|MTR_uc010pxx.1_Silent_p.H734H|MTR_uc010pxy.1_Silent_p.H639H	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	785	B12-binding.	Cobalt (cobalamin axial ligand) (By similarity).			nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GCGACGTGCACGACATAGGCA	0.488												
C1orf100	200159	broad.mit.edu	37	1	244541857	244541857	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:244541857C>A	uc001iah.2	+	4	354	c.241C>A	c.(241-243)CTT>ATT	p.L81I	C1orf100_uc001iai.2_Intron	NM_001012970	NP_001012988	Q5SVJ3	CA100_HUMAN	hypothetical protein LOC200159	81											0	all_cancers(71;3.94e-05)|all_epithelial(71;0.000138)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|all_lung(81;0.0736)|Ovarian(71;0.0761)|Lung NSC(105;0.103)		all cancers(7;8.19e-08)|GBM - Glioblastoma multiforme(7;2.05e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.000984)			ATATATTTGTCTTCGAAGACA	0.403												
CNST	163882	broad.mit.edu	37	1	246754949	246754949	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:246754949G>A	uc001ibp.2	+	2	463	c.85G>A	c.(85-87)GTG>ATG	p.V29M	CNST_uc001ibo.3_Missense_Mutation_p.V29M	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	29					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						GGAAAGGAGTGTGACCTGTCT	0.488												
NLRP3	114548	broad.mit.edu	37	1	247599290	247599290	+	Silent	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:247599290C>A	uc001icr.2	+	8	2655	c.2517C>A	c.(2515-2517)CTC>CTA	p.L839L	NLRP3_uc001ics.2_Intron|NLRP3_uc001icu.2_Silent_p.L839L|NLRP3_uc001icw.2_Silent_p.L782L|NLRP3_uc001icv.2_Intron|NLRP3_uc010pyw.1_Silent_p.L817L	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	839	LRR 4.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GCTGCTGCCTCACATCAGCAT	0.542												
NEBL	10529	broad.mit.edu	37	10	21101759	21101759	+	Silent	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr10:21101759A>C	uc001iqi.2	-	24	2854	c.2457T>G	c.(2455-2457)GCT>GCG	p.A819A	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Silent_p.A156A	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	819	Nebulin 23.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						CTTTATAGGCAGCATCGCTGA	0.527												
YME1L1	10730	broad.mit.edu	37	10	27412510	27412510	+	Silent	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr10:27412510C>G	uc001iti.2	-	11	1421	c.1239G>C	c.(1237-1239)GTG>GTC	p.V413V	YME1L1_uc001itj.2_Silent_p.V356V|YME1L1_uc010qdl.1_Silent_p.V323V|YME1L1_uc009xkv.2_Intron	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	413					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						CTCCCACACCCACAAACATCT	0.443												
GPRIN2	9721	broad.mit.edu	37	10	46999887	46999887	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr10:46999887G>T	uc001jec.2	+	3	1142	c.1007G>T	c.(1006-1008)GGT>GTT	p.G336V	GPRIN2_uc010qfq.1_Missense_Mutation_p.G99V	NM_014696	NP_055511	O60269	GRIN2_HUMAN	G protein-regulated inducer of neurite outgrowth	336											0						CAGGATGCTGGTGTGCAGGCG	0.647												
OGDHL	55753	broad.mit.edu	37	10	50948874	50948874	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr10:50948874G>T	uc001jie.2	-	16	2164	c.2022C>A	c.(2020-2022)CAC>CAA	p.H674Q	OGDHL_uc009xog.2_Missense_Mutation_p.H701Q|OGDHL_uc010qgt.1_Missense_Mutation_p.H617Q|OGDHL_uc010qgu.1_Missense_Mutation_p.H465Q	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	674					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GGAGAACATGGTGCCGGTGAC	0.637												
NDUFB8	4714	broad.mit.edu	37	10	102289218	102289218	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr10:102289218G>T	uc001kri.1	-	2	159	c.131C>A	c.(130-132)ACC>AAC	p.T44N	SEC31B_uc009xwo.1_5'UTR|SEC31B_uc010qpq.1_5'UTR|SEC31B_uc010qpr.1_RNA	NM_005004	NP_004995	O95169	NDUB8_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	44				T -> I (in Ref. 4 and 5).	mitochondrial electron transport, NADH to ubiquinone|transport	endoplasmic reticulum|integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0		Colorectal(252;0.234)		Epithelial(162;5.68e-10)|all cancers(201;4.05e-08)	NADH(DB00157)	TTCTTCTGGGGTCCTAGGATA	0.582												
PPRC1	23082	broad.mit.edu	37	10	103899167	103899167	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr10:103899167G>C	uc001kum.2	+	5	941	c.902G>C	c.(901-903)AGC>ACC	p.S301T	PPRC1_uc001kun.2_Missense_Mutation_p.S181T|PPRC1_uc010qqj.1_Missense_Mutation_p.S301T|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GGTGATGAGAGCATCTCCTCC	0.587												
SORCS3	22986	broad.mit.edu	37	10	107005390	107005390	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr10:107005390C>A	uc001kyi.1	+	21	3186	c.2959C>A	c.(2959-2961)CTC>ATC	p.L987I	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	987	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TGGGAATGCCCTCATCCAGGA	0.498												
GPAM	57678	broad.mit.edu	37	10	113933596	113933596	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr10:113933596C>A	uc009xxy.1	-	7	619	c.421G>T	c.(421-423)GAG>TAG	p.E141*	GPAM_uc001kzp.2_Nonsense_Mutation_p.E141*|GPAM_uc001kzq.1_Nonsense_Mutation_p.E141*	NM_020918	NP_065969	Q9HCL2	GPAT1_HUMAN	mitochondrial glycerol 3-phosphate	141					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)		GCAATTGCCTCTTGTACTCTG	0.363												
DOCK1	1793	broad.mit.edu	37	10	129237406	129237406	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr10:129237406A>C	uc001ljt.2	+	49	5177	c.5113A>C	c.(5113-5115)AAA>CAA	p.K1705Q	DOCK1_uc010qun.1_Missense_Mutation_p.K1726Q|DOCK1_uc009yaq.2_Missense_Mutation_p.K700Q	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1705					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		aaggaaCAGCAAACATCAAGA	0.388												
OR51G2	81282	broad.mit.edu	37	11	4936194	4936194	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr11:4936194C>T	uc001lzr.1	-	1	700	c.700G>A	c.(700-702)GCC>ACC	p.A234T		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCCCTGGAGGCGATGGACAGC	0.522												
EIF3F	8665	broad.mit.edu	37	11	8009235	8009235	+	Silent	SNP	T	T	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr11:8009235T>G	uc001mfw.2	+	1	369	c.336T>G	c.(334-336)GGT>GGG	p.G112G	EIF3F_uc010rbj.1_5'UTR	NM_003754	NP_003745	O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3,	112	MPN.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(1)	1				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCAACGAGGGTGCTGCCCGAG	0.557											OREG0020726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
C11orf84	144097	broad.mit.edu	37	11	63585493	63585493	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr11:63585493C>G	uc001nxt.2	+	2	580	c.344C>G	c.(343-345)CCT>CGT	p.P115R		NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	115											0						GAGCAGCACCCTCACACCTTG	0.642												
FAT3	120114	broad.mit.edu	37	11	92085453	92085453	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr11:92085453A>T	uc001pdj.3	+	1	192	c.175A>T	c.(175-177)AGG>TGG	p.R59W		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	59	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTCAGCAGCAAGGACCTACGT	0.493										TCGA Ovarian(4;0.039)		
USP28	57646	broad.mit.edu	37	11	113704991	113704991	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr11:113704991C>A	uc001poh.2	-	6	634	c.601G>T	c.(601-603)GAA>TAA	p.E201*	USP28_uc010rwy.1_Nonsense_Mutation_p.E76*|USP28_uc001poi.2_5'UTR|USP28_uc001poj.3_Nonsense_Mutation_p.E201*|USP28_uc010rwz.1_Nonsense_Mutation_p.E201*	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	201					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		CGACAATTTTCAAGTACATTT	0.368												
DSCAML1	57453	broad.mit.edu	37	11	117335803	117335803	+	Silent	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr11:117335803C>A	uc001prh.1	-	17	3302	c.3300G>T	c.(3298-3300)GTG>GTT	p.V1100V		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1040	Extracellular (Potential).|Fibronectin type-III 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCTTCATCTCCACGATGCTGT	0.602												
TRAPPC4	51399	broad.mit.edu	37	11	118889967	118889967	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr11:118889967G>T	uc010ryo.1	+	2	555	c.290G>T	c.(289-291)CGA>CTA	p.R97L	RPS25_uc001pun.2_5'Flank|TRAPPC4_uc010ryn.1_Missense_Mutation_p.R97L|TRAPPC4_uc010ryp.1_Intron|TRAPPC4_uc001pup.2_RNA|TRAPPC4_uc010ryq.1_Missense_Mutation_p.R97L	NM_016146	NP_057230	Q9Y296	TPPC4_HUMAN	trafficking protein particle complex 4	97					dendrite development|ER to Golgi vesicle-mediated transport	cis-Golgi network|dendrite|endoplasmic reticulum|Golgi stack|synaptic vesicle	protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		GTGTCCATTCGATTTGGCCGG	0.557												
C11orf63	79864	broad.mit.edu	37	11	122775027	122775027	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr11:122775027C>T	uc001pym.2	+	3	1036	c.739C>T	c.(739-741)CGG>TGG	p.R247W	C11orf63_uc001pyl.1_Missense_Mutation_p.R247W	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	247										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		ACGTGGCCCTCGGCGAAGGAA	0.478												
FAM118B	79607	broad.mit.edu	37	11	126110710	126110710	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr11:126110710C>G	uc001qdf.2	+	4	293	c.110C>G	c.(109-111)ACT>AGT	p.T37S	FAM118B_uc009zca.2_Missense_Mutation_p.T41S|FAM118B_uc001qdg.2_Missense_Mutation_p.T37S	NM_024556	NP_078832	Q9BPY3	F118B_HUMAN	hypothetical protein LOC79607	37											0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		AGCTTAAAAACTAAGAAGCCT	0.443												
GLB1L2	89944	broad.mit.edu	37	11	134240919	134240919	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr11:134240919G>A	uc001qhp.2	+	13	1421	c.1233G>A	c.(1231-1233)AAG>AAA	p.K411K	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	411					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		AGTCTGAAAAGCCCATCAACA	0.562												
MFAP5	8076	broad.mit.edu	37	12	8808404	8808404	+	Silent	SNP	T	T	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr12:8808404T>G	uc001qut.1	-	4	330	c.117A>C	c.(115-117)CCA>CCC	p.P39P	MFAP5_uc001qus.2_Silent_p.P39P|MFAP5_uc009zge.1_Silent_p.P39P	NM_003480	NP_003471	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5 precursor	39						microfibril	extracellular matrix structural constituent			breast(1)	1	Lung SC(5;0.184)					TGAATGTTTCTGGAGTCGCTT	0.343												
CACNB3	784	broad.mit.edu	37	12	49221573	49221573	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr12:49221573G>C	uc001rsl.1	+	13	1547	c.1346G>C	c.(1345-1347)AGT>ACT	p.S449T	CACNB3_uc010sly.1_Missense_Mutation_p.S436T|CACNB3_uc010slz.1_Missense_Mutation_p.S448T|CACNB3_uc001rsk.1_Missense_Mutation_p.S296T	NM_000725	NP_000716	P54284	CACB3_HUMAN	calcium channel, voltage-dependent, beta 3	449					axon guidance|membrane depolarization|synaptic transmission	cytosol|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0					Verapamil(DB00661)	GGGCTGCCTAGTGCTAACGGG	0.622												
ACCN2	41	broad.mit.edu	37	12	50471146	50471146	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr12:50471146G>A	uc001rvw.2	+	4	938	c.709G>A	c.(709-711)GAC>AAC	p.D237N	ACCN2_uc001rvv.2_Missense_Mutation_p.D237N|ACCN2_uc009zln.2_Missense_Mutation_p.D28N|ACCN2_uc009zlo.2_Missense_Mutation_p.D237N	NM_001095	NP_001086	P78348	ACCN2_HUMAN	amiloride-sensitive cation channel 2, neuronal	237	Extracellular (By similarity).				calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(1)	1					Amiloride(DB00594)	GGGGGAGACTGGTACGTCACC	0.657												
LASS5	91012	broad.mit.edu	37	12	50560935	50560935	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr12:50560935G>C	uc001rwd.3	-	1	163	c.146C>G	c.(145-147)TCG>TGG	p.S49W	LASS5_uc001rwe.3_5'UTR|LASS5_uc001rwf.3_RNA|LASS5_uc010smq.1_5'UTR	NM_147190	NP_671723	Q8N5B7	CERS5_HUMAN	LAG1 homolog, ceramide synthase 5	49	Helical; (Potential).				ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0						CGGGAACACCGAGAGGATGTG	0.607												
SCN8A	6334	broad.mit.edu	37	12	52200766	52200766	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr12:52200766G>A	uc001ryw.2	+	27	5674	c.5496G>A	c.(5494-5496)ATG>ATA	p.M1832I		NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1832					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	TCATCGCTATGGATCTGCCAA	0.552												
HOXC9	3225	broad.mit.edu	37	12	54394041	54394041	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr12:54394041C>T	uc001sep.2	+	2	167	c.69C>T	c.(67-69)CTC>CTT	p.L23L	HOXC9_uc001seq.2_Silent_p.L23L	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	23					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						ATGAAGACCTCCTAGCGTCCA	0.572												
SYT1	6857	broad.mit.edu	37	12	79693214	79693214	+	Silent	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr12:79693214T>C	uc001sys.2	+	9	1364	c.693T>C	c.(691-693)GAT>GAC	p.D231D	SYT1_uc001syt.2_Silent_p.D231D|SYT1_uc001syu.2_Silent_p.D228D|SYT1_uc001syv.2_Silent_p.D231D	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	231	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 1.	Calcium 2 (By similarity).|Calcium 1 (By similarity).			detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						CTGTATATGATTTTGATCGTT	0.383												
PPP1R12A	4659	broad.mit.edu	37	12	80214680	80214680	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr12:80214680T>G	uc001syz.2	-	8	1255	c.988A>C	c.(988-990)AAT>CAT	p.N330H	PPP1R12A_uc010suc.1_Missense_Mutation_p.N243H|PPP1R12A_uc001sza.2_Missense_Mutation_p.N330H|PPP1R12A_uc010sud.1_Missense_Mutation_p.N330H|PPP1R12A_uc001szb.2_Missense_Mutation_p.N330H|PPP1R12A_uc001szc.2_Missense_Mutation_p.N330H	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	330						contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						CGGGATGCATTTTTCTCTGGT	0.353												
SSH1	54434	broad.mit.edu	37	12	109182012	109182012	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr12:109182012T>A	uc001tnm.2	-	15	2989	c.2902A>T	c.(2902-2904)ACC>TCC	p.T968S	SSH1_uc001tnl.2_Missense_Mutation_p.T656S	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	968	Interaction with YWHAG.				actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						GAAGAGACGGTGAGGCCCGCC	0.632												
TCHP	84260	broad.mit.edu	37	12	110341905	110341905	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr12:110341905G>A	uc001tpn.2	+	3	505	c.352G>A	c.(352-354)GAG>AAG	p.E118K	TCHP_uc001tpo.1_RNA|TCHP_uc001tpp.2_Missense_Mutation_p.E118K	NM_001143852	NP_001137324	Q9BT92	TCHP_HUMAN	trichoplein	118	Glu-rich.|Potential.|Interaction with keratin proteins.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			skin(1)	1						AAGAATCCGGGAGCAGCACGG	0.572												
SACS	26278	broad.mit.edu	37	13	23912295	23912295	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr13:23912295C>T	uc001uon.2	-	10	6309	c.5720G>A	c.(5719-5721)CGA>CAA	p.R1907Q	SACS_uc001uoo.2_Missense_Mutation_p.R1760Q|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1907					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GGTATTCCATCGTCCTTTTGT	0.403												
POSTN	10631	broad.mit.edu	37	13	38154009	38154009	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr13:38154009T>A	uc001uwo.3	-	12	1767	c.1649A>T	c.(1648-1650)GAA>GTA	p.E550V	POSTN_uc010tet.1_Missense_Mutation_p.E78V|POSTN_uc001uwp.3_Missense_Mutation_p.E550V|POSTN_uc001uwr.2_Missense_Mutation_p.E550V|POSTN_uc001uwq.2_Missense_Mutation_p.E550V|POSTN_uc010teu.1_Missense_Mutation_p.E550V|POSTN_uc010tev.1_Missense_Mutation_p.E550V|POSTN_uc010tew.1_Missense_Mutation_p.E550V|POSTN_uc010tex.1_Missense_Mutation_p.E465V	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	550	FAS1 4.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TATCAGAATTTCTTTTTCTTC	0.403												
HTR2A	3356	broad.mit.edu	37	13	47409208	47409208	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr13:47409208A>G	uc001vbq.2	-	3	1314	c.1180T>C	c.(1180-1182)TAT>CAT	p.Y394H	HTR2A_uc001vbr.2_Missense_Mutation_p.Y294H|HTR2A_uc010acr.2_Missense_Mutation_p.Y394H	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	394	Cytoplasmic (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CACTGAATATACCGTGAAAAG	0.418												
SLITRK1	114798	broad.mit.edu	37	13	84454661	84454661	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr13:84454661C>A	uc001vlk.2	-	1	1868	c.982G>T	c.(982-984)GGT>TGT	p.G328C		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	328	Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CTGGAGCTACCCGTCGCTATC	0.547												
TEP1	7011	broad.mit.edu	37	14	20845494	20845494	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:20845494G>T	uc001vxe.2	-	41	6073	c.6033C>A	c.(6031-6033)TTC>TTA	p.F2011L	TEP1_uc010ahk.2_Missense_Mutation_p.F1354L|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.F1903L|TEP1_uc010tlh.1_Missense_Mutation_p.F349L	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	2011	WD 10.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CAGGCTTCTGGAATCTGGACA	0.527												
OR5AU1	390445	broad.mit.edu	37	14	21623524	21623524	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:21623524C>T	uc010tlp.1	-	1	661	c.661G>A	c.(661-663)GGT>AGT	p.G221S		NM_001004731	NP_001004731	Q8NGC0	O5AU1_HUMAN	olfactory receptor, family 5, subfamily AU,	221	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		ACATGAGCACCGCAGAATTTC	0.498												
FOXG1	2290	broad.mit.edu	37	14	29237814	29237814	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:29237814G>A	uc001wqe.2	+	1	1528	c.1329G>A	c.(1327-1329)ACG>ACA	p.T443T		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	443					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CCTCCTCCACGTCGCCGCAGG	0.607												
HEATR5A	25938	broad.mit.edu	37	14	31819924	31819924	+	Splice_Site	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:31819924C>A	uc001wrf.3	-	11	1610	c.1533_splice	c.e11-1	p.R511_splice	HEATR5A_uc010ami.2_Splice_Site_p.R409_splice|HEATR5A_uc001wrg.1_Splice_Site_p.R393_splice|HEATR5A_uc010tpk.1_Splice_Site_p.R804_splice	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A								binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		TATAAGAAGCCTACAATCAGA	0.259												
MIPOL1	145282	broad.mit.edu	37	14	37754628	37754628	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:37754628A>G	uc001wuc.2	+	8	1102	c.599A>G	c.(598-600)AAG>AGG	p.K200R	MIPOL1_uc010amr.2_Intron|MIPOL1_uc001wub.3_Missense_Mutation_p.K169R|MIPOL1_uc001wud.2_Missense_Mutation_p.K200R|MIPOL1_uc010ams.2_Missense_Mutation_p.K200R|MIPOL1_uc001wue.2_Missense_Mutation_p.K169R|MIPOL1_uc010amt.2_Missense_Mutation_p.K19R	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	200	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		GCACGAGCCAAGCATATGGAA	0.373												
C14orf166	51637	broad.mit.edu	37	14	52471144	52471144	+	Silent	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:52471144A>G	uc010aod.2	+	8	775	c.645A>G	c.(643-645)CTA>CTG	p.L215L	C14orf166_uc001wzm.3_Silent_p.L81L|C14orf166_uc001wzn.3_Silent_p.L77L	NM_016039	NP_057123	Q9Y224	CN166_HUMAN	homeobox prox 1	215						microtubule organizing center|nucleus|perinuclear region of cytoplasm|tRNA-splicing ligase complex	identical protein binding				0	Breast(41;0.0639)|all_epithelial(31;0.101)					TCAGAGAGCTACAGACAAAAA	0.413												
KIAA0586	9786	broad.mit.edu	37	14	58953857	58953857	+	Missense_Mutation	SNP	C	C	T	rs77810875		TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:58953857C>T	uc001xdv.3	+	21	3322	c.3049C>T	c.(3049-3051)CCT>TCT	p.P1017S	KIAA0586_uc010trr.1_Missense_Mutation_p.P1134S|KIAA0586_uc001xdt.3_Missense_Mutation_p.P1049S|KIAA0586_uc001xdu.3_Missense_Mutation_p.P1078S|KIAA0586_uc010trs.1_Missense_Mutation_p.P1008S|KIAA0586_uc010trt.1_Missense_Mutation_p.P953S|KIAA0586_uc010tru.1_Missense_Mutation_p.P953S	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	1017										ovary(1)	1						TATGGCTTTTCCTGTGAAAGA	0.368												
ZBTB1	22890	broad.mit.edu	37	14	64990077	64990077	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:64990077C>T	uc001xhh.3	+	4	2286	c.1855C>T	c.(1855-1857)CGT>TGT	p.R619C	ZBTB1_uc010aqg.2_Missense_Mutation_p.R619C|ZBTB1_uc001xhi.2_Missense_Mutation_p.R619C	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1 isoform	619	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		TTTAAGAGAGCGTCAGTTGCG	0.403												
SPTB	6710	broad.mit.edu	37	14	65268106	65268106	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:65268106G>A	uc001xht.2	-	6	714	c.660C>T	c.(658-660)ATC>ATT	p.I220I	SPTB_uc001xhr.2_Silent_p.I220I|SPTB_uc001xhs.2_Silent_p.I220I|SPTB_uc001xhu.2_Silent_p.I220I	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	220	Actin-binding.|CH 2.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TATCAAAGTCGATCAGGTCGG	0.582											OREG0022735	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
C14orf115	55237	broad.mit.edu	37	14	74825436	74825436	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:74825436G>T	uc001xpw.3	+	2	2141	c.1950G>T	c.(1948-1950)AAG>AAT	p.K650N		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	650					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		CTACCACGAAGTTCAAGGCCC	0.612												
TMED8	283578	broad.mit.edu	37	14	77809767	77809767	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:77809767T>C	uc001xto.1	-	5	514	c.514A>G	c.(514-516)AAA>GAA	p.K172E	TMED8_uc010ast.1_RNA|TMED8_uc001xtn.1_Missense_Mutation_p.K16E	NM_213601	NP_998766	Q6PL24	TMED8_HUMAN	transmembrane emp24 protein transport domain	172	GOLD.				transport	integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		AGCTTGCTTTTGAATTCCTTC	0.537												
C14orf174	161394	broad.mit.edu	37	14	77857387	77857387	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:77857387G>A	uc001xtq.1	+	3	1825	c.1825G>A	c.(1825-1827)GAA>AAA	p.E609K		NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	609											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		CCTGGAAATTGAAGAGCCATT	0.383												
TTC7B	145567	broad.mit.edu	37	14	91044497	91044497	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:91044497C>G	uc001xyp.2	-	19	2385	c.2263G>C	c.(2263-2265)GAG>CAG	p.E755Q	TTC7B_uc001xyo.2_Missense_Mutation_p.E199Q|TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	755	TPR 9.						binding			ovary(2)	2		Melanoma(154;0.222)				GCTAAGGCCTCTTCATACCAC	0.632												
JAG2	3714	broad.mit.edu	37	14	105609319	105609319	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr14:105609319G>A	uc001yqg.2	-	26	3834	c.3430C>T	c.(3430-3432)CAC>TAC	p.H1144Y	JAG2_uc010axf.2_5'UTR|JAG2_uc001yqf.2_Missense_Mutation_p.H548Y|JAG2_uc001yqh.2_Missense_Mutation_p.H1106Y	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	1144	Cytoplasmic (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		ACGTCCTTGTGGCCCCCCGGC	0.473												
TRPM1	4308	broad.mit.edu	37	15	31339349	31339349	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:31339349G>A	uc001zfm.2	-	14	1791	c.1663C>T	c.(1663-1665)CGG>TGG	p.R555W	TRPM1_uc010azy.2_Missense_Mutation_p.R462W|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	555	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TAAAGGGTCCGAAAGTTTTTC	0.517												
C15orf29	79768	broad.mit.edu	37	15	34440952	34440952	+	Splice_Site	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:34440952C>G	uc001zhp.2	-	5	599	c.439_splice	c.e5-1	p.V147_splice	C15orf29_uc010ubz.1_Splice_Site_p.V51_splice|C15orf29_uc010uca.1_Intron	NM_024713	NP_078989	Q9H079	CO029_HUMAN	hypothetical protein LOC79768							nucleolus				ovary(1)	1		all_lung(180;1.86e-06)		all cancers(64;5.49e-18)|GBM - Glioblastoma multiforme(113;8.91e-07)|BRCA - Breast invasive adenocarcinoma(123;0.026)|Lung(196;0.229)		CCTGAGAAACCTGAAAGGCAA	0.338												
ACTC1	70	broad.mit.edu	37	15	35082638	35082638	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:35082638G>C	uc001ziu.1	-	7	1352	c.1109C>G	c.(1108-1110)TCC>TGC	p.S370C	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	370					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GTGGACAATGGATGGGCCTGC	0.502												
FBN1	2200	broad.mit.edu	37	15	48797306	48797306	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:48797306C>G	uc001zwx.1	-	16	2204	c.1876G>C	c.(1876-1878)GGG>CGG	p.G626R		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	626	EGF-like 10; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ACGCAACGCCCATTCATGCAG	0.443												
CGNL1	84952	broad.mit.edu	37	15	57838432	57838432	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:57838432C>T	uc002aeg.2	+	18	3844	c.3768C>T	c.(3766-3768)GAC>GAT	p.D1256D	CGNL1_uc010bfw.2_Silent_p.D1256D	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	1256	Potential.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TGAAGAAGGACTTAAGGTGGG	0.532												
TLN2	83660	broad.mit.edu	37	15	63040577	63040577	+	Silent	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:63040577C>G	uc002alb.3	+	30	4053	c.4053C>G	c.(4051-4053)CTC>CTG	p.L1351L	TLN2_uc002alc.3_5'UTR	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1351					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						TCAATCAACTCATCACTCTGT	0.473												
TPM1	7168	broad.mit.edu	37	15	63335135	63335135	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:63335135G>A	uc002alg.2	+	1	298	c.107G>A	c.(106-108)AGC>AAC	p.S36N	TPM1_uc002alh.2_Missense_Mutation_p.S36N|TPM1_uc010bgn.2_RNA|TPM1_uc002ali.2_Missense_Mutation_p.S36N|TPM1_uc002alj.2_Missense_Mutation_p.S36N|TPM1_uc002alk.2_Missense_Mutation_p.S36N|TPM1_uc002all.2_Missense_Mutation_p.S36N|TPM1_uc002alm.2_Missense_Mutation_p.S36N|TPM1_uc010uie.1_Missense_Mutation_p.S36N|TPM1_uc002alp.2_Missense_Mutation_p.S36N	NM_001018005	NP_001018005	P09493	TPM1_HUMAN	tropomyosin 1 alpha chain isoform 1	36	By similarity.				cardiac muscle contraction|cellular component movement|cellular response to reactive oxygen species|muscle filament sliding|negative regulation of cell migration|positive regulation of ATPase activity|positive regulation of cell adhesion|positive regulation of heart rate by epinephrine|positive regulation of stress fiber assembly|regulation of muscle contraction|ruffle organization|sarcomere organization|ventricular cardiac muscle tissue morphogenesis|wound healing	bleb|cytosol|muscle thin filament tropomyosin|ruffle membrane|stress fiber	actin binding|structural constituent of cytoskeleton|structural constituent of muscle				0						GAAGACAGGAGCAAGCAGGTC	0.682												
DPP8	54878	broad.mit.edu	37	15	65792991	65792991	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:65792991C>T	uc002aov.2	-	4	2125	c.547G>A	c.(547-549)GGT>AGT	p.G183S	DPP8_uc002aow.2_Missense_Mutation_p.G183S|DPP8_uc010uiv.1_RNA|DPP8_uc002aox.2_Missense_Mutation_p.G167S|DPP8_uc002aoy.2_Missense_Mutation_p.G183S|DPP8_uc002aoz.2_Missense_Mutation_p.G167S|DPP8_uc010bhj.2_Missense_Mutation_p.G183S|DPP8_uc002apa.2_Missense_Mutation_p.G80S	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1	183					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						ATTCCACTACCGGCTTGAAAC	0.398												
TBC1D21	161514	broad.mit.edu	37	15	74180816	74180816	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:74180816G>T	uc002avz.2	+	10	1023	c.940G>T	c.(940-942)GCC>TCC	p.A314S	TBC1D21_uc010ulc.1_Missense_Mutation_p.A278S	NM_153356	NP_699187	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	314						intracellular	Rab GTPase activator activity			ovary(2)	2						GCTGATCTCTGCCGCCTGCGT	0.448												
C15orf39	56905	broad.mit.edu	37	15	75500588	75500588	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:75500588G>A	uc002azp.3	+	2	2519	c.2199G>A	c.(2197-2199)CAG>CAA	p.Q733Q	C15orf39_uc002azq.3_Silent_p.Q733Q|C15orf39_uc002azr.3_Silent_p.Q131Q	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	733											0						ctcgagctcaggctccagctt	0.244												
MEX3B	84206	broad.mit.edu	37	15	82336071	82336071	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:82336071G>A	uc002bgq.1	-	2	1455	c.1140C>T	c.(1138-1140)TTC>TTT	p.F380F		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	380					protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2						GGGACCGCTCGAACTGGGCCC	0.542												
WHAMM	123720	broad.mit.edu	37	15	83499525	83499525	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:83499525A>C	uc002bje.2	+	9	2322	c.1816A>C	c.(1816-1818)AGC>CGC	p.S606R		NM_001080435	NP_001073904	Q8TF30	WHAMM_HUMAN	WAS protein homolog associated with actin, golgi	606						cytoplasmic vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	actin binding				0						TAATGTGAAAAGCCCCAAGTG	0.458												
IGF1R	3480	broad.mit.edu	37	15	99500476	99500476	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:99500476C>T	uc002bul.2	+	21	3959	c.3909C>T	c.(3907-3909)GTC>GTT	p.V1303V	IGF1R_uc010bon.2_Silent_p.V1302V	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	1303	Cytoplasmic (Potential).				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	TGGAGAGCGTCCCCCTGGACC	0.672												
OR4F15	390649	broad.mit.edu	37	15	102358635	102358635	+	Silent	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:102358635T>C	uc010uts.1	+	1	246	c.246T>C	c.(244-246)ATT>ATC	p.I82I		NM_001001674	NP_001001674	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			CTAAGATGATTTGTGATATTT	0.453												
CHTF18	63922	broad.mit.edu	37	16	841339	841339	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr16:841339G>T	uc002cke.3	+	8	1136	c.1073G>T	c.(1072-1074)GGG>GTG	p.G358V	RPUSD1_uc002ckb.2_5'Flank|RPUSD1_uc002ckc.2_5'Flank|RPUSD1_uc002ckd.2_5'Flank|CHTF18_uc010uus.1_3'UTR|CHTF18_uc010bre.1_RNA|CHTF18_uc002ckf.3_Missense_Mutation_p.G386V|CHTF18_uc010brf.2_5'UTR|CHTF18_uc002ckg.3_5'UTR	NM_022092	NP_071375	Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor	358					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			kidney(1)	1		Hepatocellular(780;0.00335)				CTGGAGGCTGGGCTGGACCCG	0.687												
ABAT	18	broad.mit.edu	37	16	8870335	8870335	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr16:8870335G>A	uc002czc.3	+	14	1423	c.1257G>A	c.(1255-1257)CTG>CTA	p.L419L	ABAT_uc002czd.3_Silent_p.L419L|ABAT_uc010buh.2_Silent_p.L361L|ABAT_uc010bui.2_Silent_p.L419L	NM_020686	NP_065737	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase precursor	419					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	TCACAGGACTGCTGGACCTCC	0.632												
GRIN2A	2903	broad.mit.edu	37	16	9862770	9862770	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr16:9862770G>C	uc002czo.3	-	12	3081	c.2533C>G	c.(2533-2535)CTG>GTG	p.L845V	GRIN2A_uc010uym.1_Missense_Mutation_p.L845V|GRIN2A_uc010uyn.1_Missense_Mutation_p.L688V|GRIN2A_uc002czr.3_Missense_Mutation_p.L845V	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	845	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CAGAAGCGCAGCTTCCAGTAG	0.582												
NOMO1	23420	broad.mit.edu	37	16	14960412	14960412	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr16:14960412T>G	uc002dcv.2	+	15	1736	c.1670T>G	c.(1669-1671)ATA>AGA	p.I557R		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	557	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						GCTTTTGCAGTAAGCATCATG	0.478												
NOMO1	23420	broad.mit.edu	37	16	14960427	14960427	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr16:14960427A>C	uc002dcv.2	+	15	1751	c.1685A>C	c.(1684-1686)GAG>GCG	p.E562A		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	562	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						ATCATGCATGAGGATTGGTGC	0.507												
XYLT1	64131	broad.mit.edu	37	16	17252692	17252692	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr16:17252692T>A	uc002dfa.2	-	6	1449	c.1364A>T	c.(1363-1365)AAT>ATT	p.N455I		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	455	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CTACCTTGCATTGTCCCGGCC	0.473												
SEPT1	1731	broad.mit.edu	37	16	30393094	30393094	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr16:30393094C>G	uc002dxy.2	-	5	479	c.292G>C	c.(292-294)GAC>CAC	p.D98H	SEPT1_uc002dxx.2_Intron|SEPT1_uc010veq.1_Missense_Mutation_p.D145H	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	98					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			TCAGAGCAGTCCACTGAGTCC	0.582												
GPR97	222487	broad.mit.edu	37	16	57714457	57714457	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr16:57714457G>A	uc002emh.2	+	8	912	c.809G>A	c.(808-810)CGC>CAC	p.R270H	GPR97_uc010vhv.1_Missense_Mutation_p.R150H|GPR97_uc010cdd.2_RNA|GPR97_uc010cde.2_5'UTR	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	270	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						ATCCTCACACGCATCTCCCAG	0.577												
KCNG4	93107	broad.mit.edu	37	16	84270991	84270991	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr16:84270991G>A	uc010voc.1	-	2	222	c.101C>T	c.(100-102)CCG>CTG	p.P34L	KCNG4_uc002fhu.1_Missense_Mutation_p.P34L	NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	34	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						CTTGATGGACGGCGTCTCCAT	0.632												
SMG6	23293	broad.mit.edu	37	17	2090057	2090057	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:2090057G>A	uc002fub.1	-	12	3110	c.3055C>T	c.(3055-3057)CTG>TTG	p.L1019L	SMG6_uc010vqv.1_Silent_p.L111L	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	1019					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4						AGCTCCTTCAGGTCCGGGACA	0.577												
SENP3	26168	broad.mit.edu	37	17	7468308	7468308	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:7468308A>C	uc002ghm.2	+	4	1261	c.988A>C	c.(988-990)AGC>CGC	p.S330R	EIF4A1_uc002gho.1_5'UTR|SENP3_uc002ghn.1_Missense_Mutation_p.S165R	NM_015670	NP_056485	Q9H4L4	SENP3_HUMAN	SUMO1/sentrin/SMT3 specific protease 3	330					proteolysis	MLL1 complex|nucleolus	cysteine-type peptidase activity			ovary(1)|central_nervous_system(1)	2		Prostate(122;0.157)				AACGTATGGCAGCCTCATACC	0.552												
RAI1	10743	broad.mit.edu	37	17	17698318	17698318	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:17698318C>G	uc002grm.2	+	3	2525	c.2056C>G	c.(2056-2058)CTG>GTG	p.L686V	RAI1_uc002grn.1_Missense_Mutation_p.L686V	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	686						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		CAGCCCAGGGCTGTTTGAAGA	0.637												
RAD51L3	5892	broad.mit.edu	37	17	33428247	33428247	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:33428247C>A	uc002hir.2	-	9	1132	c.876G>T	c.(874-876)ATG>ATT	p.M292I	RFFL_uc002hiq.2_Missense_Mutation_p.M133I|RAD51L3_uc010ctj.2_Missense_Mutation_p.G111C|RAD51L3_uc010wcd.1_Missense_Mutation_p.M312I|RAD51L3_uc002his.2_Missense_Mutation_p.M180I|RAD51L3_uc010ctk.2_Missense_Mutation_p.M173I|RAD51L3_uc010wce.1_Missense_Mutation_p.M173I|RAD51L3_uc002hit.2_Missense_Mutation_p.M173I|RAD51L3_uc002hiu.2_Missense_Mutation_p.M115I	NM_002878	NP_002869	O75771	RA51D_HUMAN	RAD51-like 3 isoform 1	292					DNA repair|reciprocal meiotic recombination	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CCAGACACGCCATGCGCCGGC	0.617								Direct_reversal_of_damage|Homologous_recombination				
KRTAP4-2	85291	broad.mit.edu	37	17	39334306	39334306	+	Silent	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:39334306G>T	uc002hwd.2	-	1	155	c.111C>A	c.(109-111)CGC>CGA	p.R37R		NM_033062	NP_149051	Q9BYR5	KRA42_HUMAN	keratin associated protein 4-2	37	5.|20 X 5 AA repeats OF C-C-[GRQVS]-[SPT]- [VSTQ].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			AGCAGCTGGGGCGGCAGCAGG	0.657												
GAST	2520	broad.mit.edu	37	17	39871710	39871710	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:39871710G>A	uc002hxl.2	+	2	54	c.22G>A	c.(22-24)GTG>ATG	p.V8M	JUP_uc010wfs.1_Intron	NM_000805	NP_000796	P01350	GAST_HUMAN	gastrin preproprotein	8						extracellular region	hormone activity				0		Breast(137;0.000307)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			GTGTGTGTATGTGCTGATCTT	0.592												
KAT2A	2648	broad.mit.edu	37	17	40269797	40269797	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:40269797C>T	uc002hyx.2	-	9	1387	c.1327G>A	c.(1327-1329)GAG>AAG	p.E443K		NM_021078	NP_066564	Q92830	KAT2A_HUMAN	general control of amino acid synthesis 5-like	443					chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			upper_aerodigestive_tract(1)|lung(1)	2						TTGGCATCCTCCAGGGTCAGG	0.572												
BECN1	8678	broad.mit.edu	37	17	40966663	40966663	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:40966663T>C	uc002ibo.3	-	9	994	c.859A>G	c.(859-861)AAC>GAC	p.N287D	BECN1_uc010whb.1_Missense_Mutation_p.N200D|BECN1_uc010whc.1_Missense_Mutation_p.N211D|BECN1_uc002ibn.2_Missense_Mutation_p.N287D	NM_003766	NP_003757	Q14457	BECN1_HUMAN	beclin 1	287					anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			ovary(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		AGCCTGAAGTTATTGATTGTG	0.498												
GIP	2695	broad.mit.edu	37	17	47041686	47041686	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:47041686C>G	uc002iol.1	-	3	341	c.243G>C	c.(241-243)AAG>AAC	p.K81N		NM_004123	NP_004114	P09681	GIP_HUMAN	gastric inhibitory polypeptide preproprotein	81					energy reserve metabolic process|signal transduction	extracellular region|soluble fraction	hormone activity			skin(1)	1						TCTTCTTCCCCTTTTGGGCCA	0.557												
LUC7L3	51747	broad.mit.edu	37	17	48817692	48817692	+	Silent	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:48817692A>G	uc002isr.2	+	3	309	c.192A>G	c.(190-192)GAA>GAG	p.E64E	LUC7L3_uc002isp.1_5'UTR|LUC7L3_uc010wmw.1_5'UTR|LUC7L3_uc002isq.2_Silent_p.E64E|LUC7L3_uc002iss.2_Silent_p.E64E	NM_006107	NP_006098	O95232	LC7L3_HUMAN	LUC7-like 3	64					apoptosis|mRNA processing|response to stress|RNA splicing	focal adhesion|nuclear speck	DNA binding|mRNA binding|protein binding				0						TTCATGATGAAAATCTACGAA	0.323												
MRC2	9902	broad.mit.edu	37	17	60765989	60765989	+	Silent	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:60765989C>G	uc002jad.2	+	22	3591	c.3189C>G	c.(3187-3189)CCC>CCG	p.P1063P	MRC2_uc002jae.2_Silent_p.P134P|MRC2_uc002jaf.2_Missense_Mutation_p.P9R	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	1063	Extracellular (Potential).|C-type lectin 6.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CTGGGGAGCCCTCTGGCCCTA	0.632												
SCN4A	6329	broad.mit.edu	37	17	62049151	62049151	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:62049151A>C	uc002jds.1	-	4	619	c.542T>G	c.(541-543)TTC>TGC	p.F181C		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	181	I.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	GTCGACACAGAAGCCTCGGGC	0.607												
ENGASE	64772	broad.mit.edu	37	17	77077146	77077146	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:77077146A>T	uc002jwv.2	+	6	871	c.863A>T	c.(862-864)CAG>CTG	p.Q288L	ENGASE_uc002jwu.1_Missense_Mutation_p.Q288L|ENGASE_uc010wtz.1_Missense_Mutation_p.Q102L|ENGASE_uc002jww.2_5'UTR	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	288						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						GAACTCAACCAGCACAACAGG	0.657												
DUS1L	64118	broad.mit.edu	37	17	80016246	80016246	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:80016246C>T	uc002kdq.2	-	12	1672	c.1253G>A	c.(1252-1254)CGA>CAA	p.R418Q	DUS1L_uc002kdp.2_Silent_p.A284A|DUS1L_uc002kdr.2_Missense_Mutation_p.R418Q|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	418					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			TTTGGAGGCTCGCTTCTTGCA	0.672												
DUS1L	64118	broad.mit.edu	37	17	80019827	80019827	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:80019827C>T	uc002kdq.2	-	5	962	c.543G>A	c.(541-543)CAG>CAA	p.Q181Q	DUS1L_uc002kdp.2_Silent_p.Q50Q|DUS1L_uc002kdr.2_Silent_p.Q181Q|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA|DUS1L_uc010wvi.1_Silent_p.Q164Q	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	181					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			GGGGCCCCTTCTGCTCCTTGG	0.498												
CABYR	26256	broad.mit.edu	37	18	21736628	21736628	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr18:21736628C>G	uc002kux.2	+	4	1315	c.1163C>G	c.(1162-1164)TCT>TGT	p.S388C	CABYR_uc010xbb.1_Missense_Mutation_p.S290C|CABYR_uc002kuy.2_Intron|CABYR_uc002kuz.2_Intron|CABYR_uc002kva.2_Missense_Mutation_p.S370C|CABYR_uc002kvb.2_Intron|CABYR_uc002kvc.2_Intron|CABYR_uc010dlw.2_RNA	NM_012189	NP_036321	O75952	CABYR_HUMAN	calcium-binding tyrosine	388					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding				0	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					GCTCTGCTCTCTGACACATCT	0.428												
PHLPP1	23239	broad.mit.edu	37	18	60646462	60646462	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr18:60646462A>G	uc002lis.2	+	18	3594	c.3416A>G	c.(3415-3417)TAT>TGT	p.Y1139C		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	1651					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						CCTGGAGGCTATTTTGCTGCC	0.512												
GALR1	2587	broad.mit.edu	37	18	74962768	74962768	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr18:74962768C>T	uc002lms.3	+	1	761	c.264C>T	c.(262-264)TGC>TGT	p.C88C		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	88	Helical; Name=2; (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		TGCTCTTCTGCATCCCCTTCC	0.627												
SBNO2	22904	broad.mit.edu	37	19	1109765	1109765	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:1109765C>T	uc002lrk.3	-	27	3278	c.3040G>A	c.(3040-3042)GGT>AGT	p.G1014S	SBNO2_uc002lri.3_5'Flank|SBNO2_uc002lrj.3_Missense_Mutation_p.G957S|SBNO2_uc010dse.2_Missense_Mutation_p.G997S|SBNO2_uc010xgj.1_Intron	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	1014					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTCGATACCGGGAGCAAGG	0.672												
STK11	6794	broad.mit.edu	37	19	1219322	1219322	+	Splice_Site	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:1219322C>G	uc002lrl.1	+	3	1490	c.375_splice	c.e3-1	p.M125_splice		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11						anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.?(2)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGCGCCCCACGTATATGGTG	0.657		14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)		
PTPRS	5802	broad.mit.edu	37	19	5218806	5218806	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:5218806T>G	uc002mbv.2	-	24	4161	c.3927A>C	c.(3925-3927)AAA>AAC	p.K1309N	PTPRS_uc002mbu.1_Missense_Mutation_p.K878N|PTPRS_uc010xin.1_Missense_Mutation_p.K878N|PTPRS_uc002mbw.2_Missense_Mutation_p.K1287N|PTPRS_uc002mbx.2_Missense_Mutation_p.K882N|PTPRS_uc002mby.2_Missense_Mutation_p.K878N	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1309	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		ACCTGTCGGGTTTGCTGTTCC	0.517												
SLC25A23	79085	broad.mit.edu	37	19	6444244	6444244	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:6444244C>T	uc002mex.1	-	9	1282	c.1140G>A	c.(1138-1140)CTG>CTA	p.L380L	SLC25A23_uc010duu.1_RNA|SLC25A23_uc002meu.2_RNA|SLC25A23_uc002mev.2_RNA|SLC25A23_uc002mew.1_RNA|SLC25A23_uc010xjd.1_Silent_p.L141L	NM_024103	NP_077008	Q9BV35	SCMC3_HUMAN	solute carrier family 25, member 23	380	Helical; Name=5; (Potential).|Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)|pancreas(1)	2						TACCGCAGGCCAGGAGCACGA	0.642												
ARHGEF18	23370	broad.mit.edu	37	19	7523439	7523439	+	Silent	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:7523439G>T	uc002mgi.2	+	9	1912	c.1659G>T	c.(1657-1659)GTG>GTT	p.V553V	ARHGEF18_uc010xjm.1_Silent_p.V395V|ARHGEF18_uc002mgh.2_Silent_p.V395V|ARHGEF18_uc002mgj.1_Silent_p.V196V	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	553	PH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				AGCTCATCGTGAGGGAAGTGG	0.537												
STXBP2	6813	broad.mit.edu	37	19	7711164	7711164	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:7711164G>A	uc002mha.3	+	16	1431	c.1386G>A	c.(1384-1386)CCG>CCA	p.P462P	STXBP2_uc002mhb.3_Silent_p.P459P|STXBP2_uc010dvj.2_RNA|STXBP2_uc010xjr.1_Silent_p.P473P|STXBP2_uc010dvk.2_Silent_p.P430P|STXBP2_uc002mhc.3_Intron|STXBP2_uc002mhe.1_Silent_p.P90P	NM_006949	NP_008880	Q15833	STXB2_HUMAN	syntaxin binding protein 2 isoform a	462					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			central_nervous_system(1)	1						GGCTGGAGCCGAGAGAACGCA	0.677												
ACP5	54	broad.mit.edu	37	19	11687884	11687884	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:11687884G>A	uc002msg.3	-	2	395	c.249C>T	c.(247-249)GAC>GAT	p.D83D	ACP5_uc002msh.3_Silent_p.D83D|ACP5_uc002msi.3_Silent_p.D83D|ACP5_uc002msj.3_Silent_p.D83D|ACP5_uc010dye.1_Silent_p.D83D	NM_001611	NP_001602	P13686	PPA5_HUMAN	acid phosphatase 5, tartrate resistant	83					water-soluble vitamin metabolic process	cytosol|integral to membrane|lysosome	acid phosphatase activity|ferric iron binding|ferrous iron binding			central_nervous_system(1)	1						GGAACCTCTTGTCATTGATGT	0.562												
KLF1	10661	broad.mit.edu	37	19	12996891	12996891	+	Silent	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:12996891G>T	uc002mvo.2	-	2	216	c.153C>A	c.(151-153)CTC>CTA	p.L51L		NM_006563	NP_006554	Q13351	KLF1_HUMAN	erythroid Kruppel-like factor	51	Pro-rich.				erythrocyte differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0		Hepatocellular(1079;0.137)		GBM - Glioblastoma multiforme(1328;0.00016)|Lung(535;0.171)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTTCACGTGGAGGGGCGGCT	0.697												
RAB3A	5864	broad.mit.edu	37	19	18311163	18311163	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:18311163C>T	uc002nie.2	-	3	490	c.321G>A	c.(319-321)GAG>GAA	p.E107E		NM_002866	NP_002857	P20336	RAB3A_HUMAN	RAB3A, member RAS oncogene family	107					glutamate secretion|protein transport|small GTPase mediated signal transduction	clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|plasma membrane|synaptic vesicle	GTP binding|GTPase activity				0						TGAAGGATTCCTCGTTGGTGA	0.413												
GRAMD1A	57655	broad.mit.edu	37	19	35510135	35510135	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:35510135C>G	uc010xse.1	+	12	1391	c.1254C>G	c.(1252-1254)CAC>CAG	p.H418Q	GRAMD1A_uc002nxk.2_Missense_Mutation_p.H411Q|GRAMD1A_uc002nxl.2_Missense_Mutation_p.H184Q|GRAMD1A_uc010xsf.1_Missense_Mutation_p.H423Q|GRAMD1A_uc002nxm.1_RNA|GRAMD1A_uc002nxn.1_Missense_Mutation_p.H33Q	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	418						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GCAAGTGCCACCAGCGCCGGG	0.667												
ARHGAP33	115703	broad.mit.edu	37	19	36273737	36273737	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:36273737A>C	uc002obr.1	+	15	1472	c.1387A>C	c.(1387-1389)AAC>CAC	p.N463H	ARHGAP33_uc002obs.1_Missense_Mutation_p.N463H|ARHGAP33_uc002obt.1_Missense_Mutation_p.N327H|ARHGAP33_uc010eel.2_Missense_Mutation_p.N51H|ARHGAP33_uc002obv.1_Missense_Mutation_p.N51H	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	463	Rho-GAP.				cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						GCATGCCCGCAACCTGGCCAT	0.657												
ACTN4	81	broad.mit.edu	37	19	39207941	39207941	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:39207941G>A	uc002oja.1	+	10	1187	c.1128G>A	c.(1126-1128)GAG>GAA	p.E376E	ACTN4_uc010egc.1_Silent_p.E376E	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	376	Spectrin 1.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGCCCTCCGAGGGCAAGATGG	0.617												
SPTBN4	57731	broad.mit.edu	37	19	41009957	41009957	+	Missense_Mutation	SNP	G	G	A	rs145007629		TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:41009957G>A	uc002ony.2	+	12	1669	c.1583G>A	c.(1582-1584)CGG>CAG	p.R528Q	SPTBN4_uc002onx.2_Missense_Mutation_p.R528Q|SPTBN4_uc002onz.2_Missense_Mutation_p.R528Q	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	528	Spectrin 3.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGTGCCCGGCGGACACGACTT	0.652												
LTBP4	8425	broad.mit.edu	37	19	41115559	41115559	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:41115559G>C	uc002ooh.1	+	13	1751	c.1751G>C	c.(1750-1752)CGA>CCA	p.R584P	LTBP4_uc002oog.1_Missense_Mutation_p.R547P|LTBP4_uc002ooi.1_Missense_Mutation_p.R517P|LTBP4_uc002ooj.1_5'Flank|LTBP4_uc010xvo.1_5'Flank|LTBP4_uc010ehb.1_5'Flank|LTBP4_uc002ook.1_5'Flank	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	584	Cys-rich.|EGF-like 3.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CAGGGCACCCGATGCATTGGT	0.692												
GRIK5	2901	broad.mit.edu	37	19	42510076	42510076	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:42510076G>A	uc002osj.1	-	16	2097	c.2062C>T	c.(2062-2064)CGC>TGC	p.R688C	GRIK5_uc002osi.1_Missense_Mutation_p.R260C	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	688	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	TTCCACATGCGCTGGTACGTT	0.587												
GSK3A	2931	broad.mit.edu	37	19	42736796	42736796	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:42736796G>A	uc002otb.1	-	9	1256	c.1137C>T	c.(1135-1137)CTC>CTT	p.L379L	GSK3A_uc002ota.1_Silent_p.L297L|GSK3A_uc002otc.2_RNA	NM_019884	NP_063937	P49840	GSK3A_HUMAN	glycogen synthase kinase 3 alpha	379	Protein kinase.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|negative regulation of transferase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process	beta-catenin destruction complex|cytosol	ATP binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|tau-protein kinase activity			ovary(2)|lung(2)	4		Prostate(69;0.00682)				GGCTAGAGCAGAGCGCGATGG	0.587												
IRGC	56269	broad.mit.edu	37	19	44223739	44223739	+	Silent	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:44223739C>G	uc002oxh.2	+	2	1176	c.1029C>G	c.(1027-1029)GTC>GTG	p.V343V		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	343						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CTGAGACTGTCCTGCGGCTCT	0.672												
ZNF230	7773	broad.mit.edu	37	19	44514462	44514462	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:44514462C>A	uc002oyb.1	+	5	522	c.271C>A	c.(271-273)CCT>ACT	p.P91T		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	91	KRNB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				TGAAGACTGCCCTTGCCAGCA	0.438												
ZNF233	353355	broad.mit.edu	37	19	44778486	44778486	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:44778486A>G	uc002oyz.1	+	5	1800	c.1673A>G	c.(1672-1674)CAT>CGT	p.H558R	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.H373R	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	558	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				CAGCAAGTCCATACTGGAGAG	0.478												
ZNF296	162979	broad.mit.edu	37	19	45574995	45574995	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:45574995C>T	uc002pao.2	-	3	1349	c.1292G>A	c.(1291-1293)CGC>CAC	p.R431H		NM_145288	NP_660331	Q8WUU4	ZN296_HUMAN	zinc finger protein 296	431	C2H2-type 5.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCGGCGGTGGCGGTTGAGCTT	0.667												
PPM1N	147699	broad.mit.edu	37	19	46002514	46002514	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:46002514C>A	uc002pce.2	+	1	784	c.784C>A	c.(784-786)CGC>AGC	p.R262S	RTN2_uc002pcb.2_5'Flank|RTN2_uc002pcc.2_5'Flank|RTN2_uc002pcd.2_5'Flank|PPM1N_uc002pcf.2_5'Flank	NM_001080401	NP_001073870	Q8N819	PPM1N_HUMAN	protein phosphatase 1B-like	262	PP2C-like.						magnesium ion binding|manganese ion binding|phosphoprotein phosphatase activity				0						CGCACTGGCACGCCAGGCTGA	0.662												
CCDC9	26093	broad.mit.edu	37	19	47774720	47774720	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:47774720C>T	uc010xym.1	+	12	1588	c.1381C>T	c.(1381-1383)CCC>TCC	p.P461S		NM_015603	NP_056418	Q9Y3X0	CCDC9_HUMAN	coiled-coil domain containing 9	461											0		all_cancers(25;0.0432)|all_epithelial(76;0.00812)|Medulloblastoma(540;0.0208)|all_neural(266;0.0416)|Hepatocellular(1079;0.114)		OV - Ovarian serous cystadenocarcinoma(262;8.51e-95)|Epithelial(262;1.15e-92)|all cancers(93;7.67e-84)|GBM - Glioblastoma multiforme(486;0.024)|STAD - Stomach adenocarcinoma(1328;0.183)		CACCGGGATCCCCTGCAGTGA	0.512												
EHD2	30846	broad.mit.edu	37	19	48244185	48244185	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:48244185G>A	uc002phj.3	+	6	1378	c.1128G>A	c.(1126-1128)CCG>CCA	p.P376P	EHD2_uc010xyu.1_Silent_p.P240P|EHD2_uc010xyv.1_Silent_p.P59P	NM_014601	NP_055416	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	376					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		CGCTGAAGCCGAAGCTGCTAG	0.642												
ZNF677	342926	broad.mit.edu	37	19	53741187	53741187	+	Missense_Mutation	SNP	A	A	G	rs141599719		TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:53741187A>G	uc002qbf.1	-	5	978	c.793T>C	c.(793-795)TGT>CGT	p.C265R	ZNF677_uc002qbg.1_Missense_Mutation_p.C265R	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	265	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		CAGTCATTACACTTGTATGAT	0.343												
PRKCG	5582	broad.mit.edu	37	19	54409676	54409676	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:54409676C>T	uc002qcq.1	+	17	2152	c.1870C>T	c.(1870-1872)CGA>TGA	p.R624*	PRKCG_uc010yeg.1_Nonsense_Mutation_p.R624*|PRKCG_uc010yeh.1_Nonsense_Mutation_p.R475*	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	624	AGC-kinase C-terminal.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		GCGGCTGGAACGATTGGAGAT	0.622											OREG0025667	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
TMEM190	147744	broad.mit.edu	37	19	55889085	55889085	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:55889085C>G	uc002qkt.1	+	3	237	c.219C>G	c.(217-219)GAC>GAG	p.D73E		NM_139172	NP_631911	Q8WZ59	TM190_HUMAN	transmembrane protein 190 precursor	73	Extracellular (Potential).					integral to membrane					0	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		AGCGTCCAGACGGTGAGGGCT	0.682												
NLRP4	147945	broad.mit.edu	37	19	56388502	56388502	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:56388502C>T	uc002qmd.3	+	8	3088	c.2666C>T	c.(2665-2667)ACG>ATG	p.T889M	NLRP4_uc002qmf.2_Missense_Mutation_p.T814M|NLRP4_uc010etf.2_Missense_Mutation_p.T664M	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	889							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CGGGCTCTGACGCATACGGAT	0.493												
ZSCAN4	201516	broad.mit.edu	37	19	58189625	58189625	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:58189625C>T	uc002qpu.2	+	5	1351	c.654C>T	c.(652-654)TCC>TCT	p.S218S		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	218					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAATAGTTTCCCTAATCATCA	0.403												
OTOF	9381	broad.mit.edu	37	2	26699838	26699838	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:26699838G>A	uc002rhk.2	-	22	2724	c.2597C>T	c.(2596-2598)CCC>CTC	p.P866L	OTOF_uc002rhh.2_Missense_Mutation_p.P119L|OTOF_uc002rhi.2_Missense_Mutation_p.P176L|OTOF_uc002rhj.2_Missense_Mutation_p.P119L	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	866	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCCTTGGAGGGCACACGGGC	0.612												
KIAA1841	84542	broad.mit.edu	37	2	61310371	61310371	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:61310371A>C	uc002saw.3	+	8	1115	c.812A>C	c.(811-813)AAT>ACT	p.N271T	KIAA1841_uc002sax.3_Missense_Mutation_p.N125T|KIAA1841_uc002say.2_Missense_Mutation_p.N271T|KIAA1841_uc002sav.3_Missense_Mutation_p.N271T	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	271											0			Epithelial(17;0.193)			ATTAATGCAAATCTTCTCACA	0.299												
VPS54	51542	broad.mit.edu	37	2	64144060	64144060	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:64144060G>A	uc002scq.2	-	16	2365	c.2202C>T	c.(2200-2202)GTC>GTT	p.V734V	VPS54_uc002scp.2_Silent_p.V722V|VPS54_uc002scn.2_5'UTR|VPS54_uc002sco.2_Silent_p.V219V|VPS54_uc010fct.2_Silent_p.V581V	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	734					protein transport|retrograde transport, endosome to Golgi						0						GTTGTCCCTCGACAATAAGAA	0.388												
ZNF638	27332	broad.mit.edu	37	2	71653954	71653954	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:71653954A>T	uc002shx.2	+	24	5274	c.4955A>T	c.(4954-4956)GAT>GTT	p.D1652V	ZNF638_uc002shy.2_Missense_Mutation_p.D1652V|ZNF638_uc002shz.2_Missense_Mutation_p.D1652V|ZNF638_uc002sia.2_Missense_Mutation_p.D1652V|ZNF638_uc002sib.1_3'UTR|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Missense_Mutation_p.D749V|ZNF638_uc002sid.2_Missense_Mutation_p.D21V	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1652					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						ATTGACCAAGATGATTGCATT	0.353												
DYSF	8291	broad.mit.edu	37	2	71747335	71747335	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:71747335C>A	uc002sie.2	+	10	1310	c.934C>A	c.(934-936)CCC>ACC	p.P312T	DYSF_uc010feg.2_Missense_Mutation_p.P343T|DYSF_uc010feh.2_Missense_Mutation_p.P312T|DYSF_uc002sig.3_Missense_Mutation_p.P312T|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.P312T|DYSF_uc010fef.2_Missense_Mutation_p.P343T|DYSF_uc010fei.2_Missense_Mutation_p.P343T|DYSF_uc010fek.2_Missense_Mutation_p.P344T|DYSF_uc010fej.2_Missense_Mutation_p.P313T|DYSF_uc010fel.2_Missense_Mutation_p.P313T|DYSF_uc010feo.2_Missense_Mutation_p.P344T|DYSF_uc010fem.2_Missense_Mutation_p.P313T|DYSF_uc010fen.2_Missense_Mutation_p.P344T|DYSF_uc002sif.2_Missense_Mutation_p.P313T	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	312	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TTACAGAGAGCCCCGTGAGTT	0.458												
DYSF	8291	broad.mit.edu	37	2	71883377	71883377	+	Missense_Mutation	SNP	C	C	T	rs144422408		TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:71883377C>T	uc002sie.2	+	42	4971	c.4595C>T	c.(4594-4596)ACG>ATG	p.T1532M	DYSF_uc010feg.2_Missense_Mutation_p.T1563M|DYSF_uc010feh.2_Missense_Mutation_p.T1539M|DYSF_uc002sig.3_Missense_Mutation_p.T1518M|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.T1553M|DYSF_uc010fef.2_Missense_Mutation_p.T1570M|DYSF_uc010fei.2_Missense_Mutation_p.T1549M|DYSF_uc010fek.2_Missense_Mutation_p.T1550M|DYSF_uc010fej.2_Missense_Mutation_p.T1540M|DYSF_uc010fel.2_Missense_Mutation_p.T1519M|DYSF_uc010feo.2_Missense_Mutation_p.T1564M|DYSF_uc010fem.2_Missense_Mutation_p.T1554M|DYSF_uc010fen.2_Missense_Mutation_p.T1571M|DYSF_uc002sif.2_Missense_Mutation_p.T1533M|DYSF_uc010yqy.1_Missense_Mutation_p.T413M|DYSF_uc010yqz.1_Missense_Mutation_p.T293M	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1532	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CGGGGCAAGACGCAGGAGGAG	0.522												
ALMS1	7840	broad.mit.edu	37	2	73784420	73784420	+	Silent	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:73784420A>C	uc002sje.1	+	16	10266	c.10155A>C	c.(10153-10155)ACA>ACC	p.T3385T	ALMS1_uc002sjf.1_Silent_p.T3341T|ALMS1_uc002sjg.2_Silent_p.T2771T|ALMS1_uc002sjh.1_Silent_p.T2771T|ALMS1_uc010fev.1_Silent_p.T143T	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3383					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TTCACAGTACAAGGGCAGTGA	0.423												
TCF7L1	83439	broad.mit.edu	37	2	85536584	85536584	+	Silent	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:85536584A>G	uc002soy.2	+	12	1840	c.1766A>G	c.(1765-1767)TAA>TGA	p.*589*		NM_031283	NP_112573	Q9HCS4	TF7L1_HUMAN	HMG-box transcription factor TCF-3	589					chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)|central_nervous_system(1)	3						TCTGCCCACTAAGCTCCCCCC	0.557												
ASTL	431705	broad.mit.edu	37	2	96789646	96789646	+	Silent	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:96789646T>C	uc010yui.1	-	9	1239	c.1239A>G	c.(1237-1239)CCA>CCG	p.P413P		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	413					proteolysis		metalloendopeptidase activity|zinc ion binding				0						CTGGCAGAGCTGGGCTTCCCT	0.587												
MAP4K4	9448	broad.mit.edu	37	2	102476248	102476248	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:102476248G>A	uc002tbg.2	+	15	1681	c.1626G>A	c.(1624-1626)CCG>CCA	p.P542P	MAP4K4_uc002tbc.2_Silent_p.P542P|MAP4K4_uc002tbd.2_Silent_p.P511P|MAP4K4_uc002tbe.2_Silent_p.P511P|MAP4K4_uc002tbf.2_Silent_p.P511P|MAP4K4_uc010yvy.1_Silent_p.P511P|MAP4K4_uc002tbh.2_Silent_p.P511P|MAP4K4_uc002tbi.2_Silent_p.P395P|MAP4K4_uc010yvz.1_Silent_p.P491P|MAP4K4_uc002tbk.2_Silent_p.P51P|MAP4K4_uc002tbj.1_Silent_p.P407P	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	542					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CGCCACCACCGCAGCAGGAAA	0.592												
CCDC74B	91409	broad.mit.edu	37	2	130897829	130897829	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:130897829G>A	uc002tqm.1	-	5	861	c.799C>T	c.(799-801)CGA>TGA	p.R267*	CCDC74B_uc010yzw.1_Nonsense_Mutation_p.R369*|CCDC74B_uc002tqn.1_Nonsense_Mutation_p.R201*	NM_207310	NP_997193	Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	267											0	Colorectal(110;0.1)					GTGGGCTTTCGCAGGGGAAGG	0.647												
LCT	3938	broad.mit.edu	37	2	136566925	136566925	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:136566925C>A	uc002tuu.1	-	8	3003	c.2992G>T	c.(2992-2994)GAT>TAT	p.D998Y		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	998	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TTGTAATAATCAACCCCATGA	0.507												
KCNJ3	3760	broad.mit.edu	37	2	155566194	155566194	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:155566194A>C	uc002tyv.1	+	2	977	c.782A>C	c.(781-783)CAA>CCA	p.Q261P	KCNJ3_uc010zce.1_Intron	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	261	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	GGGGCAGATCAACTTTTTCTT	0.483												
SCN3A	6328	broad.mit.edu	37	2	166026964	166026964	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:166026964A>C	uc002ucx.2	-	4	851	c.359T>G	c.(358-360)ATT>AGT	p.I120S	SCN3A_uc002ucy.2_Missense_Mutation_p.I120S|SCN3A_uc002ucz.2_Missense_Mutation_p.I120S|SCN3A_uc002uda.1_5'Flank|SCN3A_uc002udb.1_5'Flank	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	120						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CTTGATAGCAATTTTCCTAAC	0.303												
G6PC2	57818	broad.mit.edu	37	2	169763222	169763222	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:169763222T>A	uc002uem.2	+	4	581	c.489T>A	c.(487-489)AGT>AGA	p.S163R	G6PC2_uc002uen.2_Intron|G6PC2_uc010fpv.2_Missense_Mutation_p.S47R	NM_021176	NP_066999	Q9NQR9	G6PC2_HUMAN	islet-specific glucose-6-phosphatase-related	163	Helical; (Potential).				gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			pancreas(1)	1						TTCAAATCAGTGTCTGCATCT	0.373												
HOXD3	3232	broad.mit.edu	37	2	177036786	177036786	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:177036786C>T	uc002ukt.1	+	3	1259	c.1083C>T	c.(1081-1083)AAC>AAT	p.N361N		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	361					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		TGGGCGGCAACTTCGTCGAGT	0.701												
TTN	7273	broad.mit.edu	37	2	179470142	179470142	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:179470142T>A	uc010zfg.1	-	228	46400	c.46176A>T	c.(46174-46176)GAA>GAT	p.E15392D	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E9087D|TTN_uc010zfi.1_Missense_Mutation_p.E9020D|TTN_uc010zfj.1_Missense_Mutation_p.E8895D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16319							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTCCGCACCTTCATCATCTT	0.333												
TTN	7273	broad.mit.edu	37	2	179631273	179631273	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:179631273A>G	uc010zfg.1	-	41	9762	c.9538T>C	c.(9538-9540)TAT>CAT	p.Y3180H	TTN_uc010zfh.1_Missense_Mutation_p.Y3134H|TTN_uc010zfi.1_Missense_Mutation_p.Y3134H|TTN_uc010zfj.1_Missense_Mutation_p.Y3134H|TTN_uc002umz.1_5'Flank|TTN_uc002unb.2_Missense_Mutation_p.Y3180H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	3180							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATCTTTATACCAGTGGGCA	0.383												
TTN	7273	broad.mit.edu	37	2	179635333	179635333	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:179635333T>G	uc010zfg.1	-	35	8410	c.8186A>C	c.(8185-8187)GAG>GCG	p.E2729A	TTN_uc010zfh.1_Missense_Mutation_p.E2683A|TTN_uc010zfi.1_Missense_Mutation_p.E2683A|TTN_uc010zfj.1_Missense_Mutation_p.E2683A|TTN_uc002unb.2_Missense_Mutation_p.E2729A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2729							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGTGTAAGCTCGACAGTGAA	0.383												
LANCL1	10314	broad.mit.edu	37	2	211319933	211319933	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:211319933C>T	uc010zjh.1	-	4	380	c.305G>A	c.(304-306)CGC>CAC	p.R102H	LANCL1_uc002ved.2_Missense_Mutation_p.R102H|LANCL1_uc010fuq.2_Missense_Mutation_p.R102H	NM_001136574	NP_001130046	O43813	LANC1_HUMAN	lanthionine synthetase C-like protein 1	102						cytoplasm|integral to plasma membrane|microtubule cytoskeleton|nucleus	catalytic activity|G-protein coupled receptor activity|glutathione binding|low-density lipoprotein particle receptor binding|SH3 domain binding|zinc ion binding				0				Epithelial(149;0.00562)|Lung(261;0.0468)|LUSC - Lung squamous cell carcinoma(261;0.0495)|all cancers(144;0.0569)		GGTGATGGAGCGCTTGGTTAA	0.483												
SPEG	10290	broad.mit.edu	37	2	220353257	220353257	+	Silent	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:220353257C>A	uc010fwg.2	+	33	7896	c.7896C>A	c.(7894-7896)ATC>ATA	p.I2632I		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2632	Ig-like 9.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CAGTGATCATCGTGTCCTGCA	0.632												
GIGYF2	26058	broad.mit.edu	37	2	233599885	233599885	+	Translation_Start_Site	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:233599885C>G	uc002vti.3	+	5	315	c.-22C>G	c.(-24--20)ATCTA>ATGTA		GIGYF2_uc002vte.2_RNA|GIGYF2_uc002vtf.2_RNA|GIGYF2_uc010zmj.1_Translation_Start_Site|GIGYF2_uc002vtg.2_Translation_Start_Site|GIGYF2_uc002vtj.3_Translation_Start_Site|GIGYF2_uc002vtk.3_Translation_Start_Site|GIGYF2_uc002vth.3_Translation_Start_Site|GIGYF2_uc002vtl.2_RNA|GIGYF2_uc010zmk.1_RNA	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b						cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		ATATAAAAATCTATTGTAAAA	0.353												
UGT1A4	54657	broad.mit.edu	37	2	234627873	234627873	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:234627873C>T	uc002vux.2	+	1	436	c.407C>T	c.(406-408)GCC>GTC	p.A136V	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Missense_Mutation_p.A136V	NM_007120	NP_009051	P22310	UD14_HUMAN	UDP glycosyltransferase 1 family, polypeptide A4	136					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)	Imipramine(DB00458)|Lamotrigine(DB00555)|Paricalcitol(DB00910)|Trifluoperazine(DB00831)	CATAATGAGGCCCTGATCAGG	0.458												
IQCA1	79781	broad.mit.edu	37	2	237247012	237247012	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:237247012C>T	uc002vvz.1	-	17	2152	c.1970G>A	c.(1969-1971)CGC>CAC	p.R657H	IQCA1_uc002vwb.2_Missense_Mutation_p.R665H|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Missense_Mutation_p.R616H	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	657							ATP binding			ovary(1)	1						TTTTTTCAGGCGTTTAGGTTC	0.408												
ASB1	51665	broad.mit.edu	37	2	239344628	239344628	+	Silent	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:239344628G>T	uc002vyg.2	+	3	554	c.468G>T	c.(466-468)CGG>CGT	p.R156R		NM_001040445	NP_001035535	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box-containing protein	156	ANK 4.				intracellular signal transduction|negative regulation of cytokine biosynthetic process						0		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		GCGTGGGCCGGGCAGACATCC	0.542												
TGM6	343641	broad.mit.edu	37	20	2384321	2384321	+	Silent	SNP	C	C	T	rs145029765		TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr20:2384321C>T	uc002wfy.1	+	9	1249	c.1188C>T	c.(1186-1188)AAC>AAT	p.N396N	TGM6_uc010gal.1_Silent_p.N396N	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	396		Calcium (By similarity).			cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CGGAGGTCAACGCCGACTACA	0.617												
SLC4A11	83959	broad.mit.edu	37	20	3211489	3211489	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr20:3211489C>T	uc002wig.2	-	10	1267	c.1219G>A	c.(1219-1221)GTG>ATG	p.V407M	SLC4A11_uc010zqe.1_Missense_Mutation_p.V434M|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.V391M	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	407	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						GTCTTCTGCACGTCTGTGGGG	0.711												
ESF1	51575	broad.mit.edu	37	20	13763319	13763319	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr20:13763319C>A	uc002woj.2	-	2	576	c.468G>T	c.(466-468)AAG>AAT	p.K156N	ESF1_uc002wok.1_Missense_Mutation_p.K156N|C20orf7_uc002wol.1_5'Flank|C20orf7_uc002wom.2_5'Flank|C20orf7_uc002won.2_5'Flank|C20orf7_uc002woo.2_5'Flank	NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	156	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1						CTTTGCTATCCTTCTTCGGAC	0.274												
CBFA2T2	9139	broad.mit.edu	37	20	32224501	32224501	+	Silent	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr20:32224501T>C	uc002wzg.1	+	10	1848	c.1311T>C	c.(1309-1311)TTT>TTC	p.F437F	CBFA2T2_uc010zug.1_Silent_p.F211F|CBFA2T2_uc002wze.1_Silent_p.F428F|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Silent_p.F408F|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA|CBFA2T2_uc002wzk.1_5'Flank	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	437						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						CTGTGGAGTTTTGGAAAAAAA	0.438												
RALGAPB	57148	broad.mit.edu	37	20	37174983	37174983	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr20:37174983C>A	uc002xiw.2	+	19	3069	c.2812C>A	c.(2812-2814)CCA>ACA	p.P938T	RALGAPB_uc002xix.2_Missense_Mutation_p.P934T|RALGAPB_uc002xiy.1_Missense_Mutation_p.P938T|RALGAPB_uc002xiz.2_Missense_Mutation_p.P716T|RALGAPB_uc002xja.1_Missense_Mutation_p.P665T	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	938					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						CTCCAGGCTGCCAACCATAAA	0.443												
PTPRT	11122	broad.mit.edu	37	20	40790084	40790084	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr20:40790084G>T	uc002xkg.2	-	17	2774	c.2590C>A	c.(2590-2592)CAG>AAG	p.Q864K	PTPRT_uc010ggj.2_Missense_Mutation_p.Q883K|PTPRT_uc010ggi.2_Missense_Mutation_p.Q67K	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	864	Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGTTGGAACTGGTCCCGGGGG	0.612												
CYP24A1	1591	broad.mit.edu	37	20	52774059	52774059	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr20:52774059C>T	uc002xwv.2	-	10	1700	c.1302G>A	c.(1300-1302)CAG>CAA	p.Q434Q	CYP24A1_uc002xwu.1_Silent_p.Q292Q|CYP24A1_uc002xww.2_Intron	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	434					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	CAGGTCTAAACTGACTTGAAT	0.398												
OPRL1	4987	broad.mit.edu	37	20	62724306	62724306	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr20:62724306G>T	uc002yic.2	+	3	635	c.233G>T	c.(232-234)AGG>ATG	p.R78M	OPRL1_uc002yid.2_Missense_Mutation_p.R78M|OPRL1_uc002yif.3_Intron	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	78	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GTCATCCTCAGGTAGGCTGGG	0.622												
DOPEY2	9980	broad.mit.edu	37	21	37617880	37617880	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr21:37617880A>T	uc002yvg.2	+	19	3681	c.3602A>T	c.(3601-3603)GAG>GTG	p.E1201V	DOPEY2_uc011aeb.1_Missense_Mutation_p.E1150V|DOPEY2_uc002yvh.2_Missense_Mutation_p.E52V	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1201					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						GCGGACTTGGAGCTCCAGGCC	0.617												
PCNT	5116	broad.mit.edu	37	21	47786946	47786946	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr21:47786946G>A	uc002zji.3	+	15	3164	c.3057G>A	c.(3055-3057)CTG>CTA	p.L1019L	PCNT_uc002zjj.2_Silent_p.L901L	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1019	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TGGAGAAACTGAAGCGGAAAC	0.547												
IL17RA	23765	broad.mit.edu	37	22	17577950	17577950	+	Splice_Site	SNP	A	A	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr22:17577950A>T	uc002zly.2	+	2	272	c.139_splice	c.e2-2	p.G47_splice	IL17RA_uc010gqt.2_Splice_Site_p.G47_splice	NM_014339	NP_055154	Q96F46	I17RA_HUMAN	interleukin 17A receptor precursor						fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			skin(2)	2		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		TTTTTTCCACAGGGGCTAAAC	0.463												
APOL5	80831	broad.mit.edu	37	22	36123193	36123193	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr22:36123193A>G	uc003aof.2	+	3	1078	c.1078A>G	c.(1078-1080)AGC>GGC	p.S360G		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	360					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						GACCTGTTCCAGCTCCCGGGG	0.587												
CYTH4	27128	broad.mit.edu	37	22	37690712	37690712	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr22:37690712T>A	uc003arf.2	+	3	230	c.114T>A	c.(112-114)GAT>GAA	p.D38E	CYTH4_uc003ard.3_Missense_Mutation_p.D38E|CYTH4_uc003are.2_Missense_Mutation_p.D38E|CYTH4_uc011amw.1_5'UTR|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	38	Potential.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						AGCTGAAGGATGAGATTGCAG	0.607												
MICALL1	85377	broad.mit.edu	37	22	38322052	38322052	+	Splice_Site	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr22:38322052T>C	uc003aui.2	+	8	1549	c.1465_splice	c.e8+2	p.A489_splice		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	molecule interacting with Rab13							cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)	1	Melanoma(58;0.045)					CCCCACTGGGTGAGTGCCTTT	0.627												
PHF21B	112885	broad.mit.edu	37	22	45312274	45312274	+	Silent	SNP	G	G	A	rs115694109	byFrequency	TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr22:45312274G>A	uc003bfn.2	-	4	601	c.450C>T	c.(448-450)TAC>TAT	p.Y150Y	PHF21B_uc003bfm.2_Translation_Start_Site|PHF21B_uc011aqk.1_Silent_p.Y138Y|PHF21B_uc011aql.1_Silent_p.Y150Y|PHF21B_uc011aqm.1_Silent_p.Y138Y	NM_138415	NP_612424	Q96EK2	PF21B_HUMAN	PHD finger protein 21B isoform 1	150							zinc ion binding			ovary(2)|skin(1)	3		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		AGATGATGGCGTAGGCCACCC	0.692												
LMCD1	29995	broad.mit.edu	37	3	8590314	8590314	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:8590314G>A	uc003bqq.2	+	4	562	c.448G>A	c.(448-450)GCC>ACC	p.A150T	LMCD1_uc011atd.1_Missense_Mutation_p.A77T|LMCD1_uc011ate.1_Missense_Mutation_p.A38T|LMCD1_uc011atf.1_Missense_Mutation_p.A77T	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	150	PET.				positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		CACAGAGGGTGCCTTTTACCG	0.567												
TTLL3	26140	broad.mit.edu	37	3	9859368	9859368	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:9859368G>C	uc003btg.2	+	5	571	c.355G>C	c.(355-357)GAT>CAT	p.D119H	ARPC4_uc003btc.1_Intron|TTLL3_uc003btd.3_Missense_Mutation_p.D119H|TTLL3_uc003btf.3_5'UTR|TTLL3_uc010hco.1_Missense_Mutation_p.D55H|TTLL3_uc003bth.3_5'UTR|TTLL3_uc011atj.1_Missense_Mutation_p.D55H|TTLL3_uc003btj.3_5'UTR|TTLL3_uc003bti.3_5'UTR	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	119					axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					GCCGTGGTTTGATGAGGTTGA	0.562												
IL17RE	132014	broad.mit.edu	37	3	9948410	9948410	+	Silent	SNP	T	T	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:9948410T>A	uc003btu.2	+	6	504	c.387T>A	c.(385-387)CGT>CGA	p.R129R	CIDEC_uc003bto.2_Intron|IL17RE_uc003btv.2_Silent_p.R129R|IL17RE_uc011atn.1_RNA|IL17RE_uc003btw.2_Silent_p.R129R|IL17RE_uc003btx.2_Silent_p.R13R|IL17RE_uc010hcq.2_Silent_p.R129R|IL17RE_uc003bty.2_RNA	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	129	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		TGCCTCGTCGTCACCTGTCTG	0.418												
GRIP2	80852	broad.mit.edu	37	3	14545116	14545116	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:14545116G>A	uc011avi.1	-	22	2931	c.2931C>T	c.(2929-2931)GAC>GAT	p.D977D	GRIP2_uc010heh.2_RNA|GRIP2_uc011avh.1_Silent_p.D508D	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	879					synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						ATGACTCCAGGTCTTCGAGAG	0.622												
TGFBR2	7048	broad.mit.edu	37	3	30713543	30713543	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:30713543G>A	uc003ceo.2	+	4	1250	c.868G>A	c.(868-870)GAG>AAG	p.E290K	TGFBR2_uc003cen.2_Missense_Mutation_p.E315K	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	290	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						TTGGAAGACAGAGAAGGACAT	0.483												
ATXN7	6314	broad.mit.edu	37	3	63968005	63968005	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:63968005C>A	uc003dlw.3	+	7	1449	c.896C>A	c.(895-897)ACC>AAC	p.T299N	ATXN7_uc003dlv.2_Missense_Mutation_p.T299N|ATXN7_uc010hnv.2_Missense_Mutation_p.T299N|ATXN7_uc011bfn.1_Missense_Mutation_p.T154N	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	299					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		CCAAAGCCAACCTTGCCTTCA	0.488												
GPR128	84873	broad.mit.edu	37	3	100362456	100362456	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:100362456G>A	uc003duc.2	+	8	1193	c.925G>A	c.(925-927)GTC>ATC	p.V309I	GPR128_uc011bhc.1_Intron	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	309	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						TGAGCTTCAGGTCTTGCTTAA	0.363												
ARHGAP31	57514	broad.mit.edu	37	3	119133205	119133205	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:119133205C>G	uc003ecj.3	+	12	2961	c.2429C>G	c.(2428-2430)TCC>TGC	p.S810C		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	810					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						GAAGACTCATCCAGGAAATTG	0.562												
COL6A6	131873	broad.mit.edu	37	3	130279257	130279257	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:130279257G>C	uc010htl.2	+	1	80	c.49G>C	c.(49-51)GTG>CTG	p.V17L		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	17					axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CCATATTTCTGTGAACCAAGA	0.279												
CEP70	80321	broad.mit.edu	37	3	138248274	138248274	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:138248274T>G	uc003esl.2	-	9	921	c.723A>C	c.(721-723)GAA>GAC	p.E241D	CEP70_uc011bmk.1_Missense_Mutation_p.E221D|CEP70_uc011bml.1_Missense_Mutation_p.E223D|CEP70_uc011bmm.1_Missense_Mutation_p.E89D|CEP70_uc003esm.2_Missense_Mutation_p.E241D	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	241					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						CGTTTTCTTCTTCTGACTGAC	0.294												
FOXL2	668	broad.mit.edu	37	3	138665218	138665218	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:138665218G>T	uc003esw.2	-	1	765	c.347C>A	c.(346-348)CCG>CAG	p.P116Q	uc003esv.1_5'Flank|C3orf72_uc003esx.1_5'Flank|C3orf72_uc011bmr.1_5'Flank	NM_023067	NP_075555	P58012	FOXL2_HUMAN	forkhead box L2	116	Fork-head.				convergent extension|DNA fragmentation involved in apoptotic nuclear change|embryonic eye morphogenesis|extraocular skeletal muscle development|female somatic sex determination|induction of apoptosis|menstruation|negative regulation of transcription, DNA-dependent|ovarian follicle development|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			ovary(266)|large_intestine(1)|skin(1)	268						GCCCTCGCGCGGCACCTTGAT	0.607			Mis		granulosa-cell tumour of the ovary		Blepharophimosis|ptosis and epicanthus inversus Types I|II; Premature ovarian failure type III					
ATR	545	broad.mit.edu	37	3	142188342	142188342	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:142188342G>C	uc003eux.3	-	38	6511	c.6389C>G	c.(6388-6390)ACA>AGA	p.T2130R	ATR_uc003euy.1_Missense_Mutation_p.T16R	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2130	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TAAATAGTTTGTATGCTCTGT	0.348								Other_conserved_DNA_damage_response_genes				
AADACL2	344752	broad.mit.edu	37	3	151463297	151463297	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:151463297C>A	uc003ezc.2	+	4	552	c.432C>A	c.(430-432)GAC>GAA	p.D144E	AADACL2_uc010hvn.2_5'UTR	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	144						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TTCTTTAAAGCTATAGGCTGG	0.343												
USP13	8975	broad.mit.edu	37	3	179459996	179459996	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:179459996C>T	uc003fkh.2	+	12	1473	c.1392C>T	c.(1390-1392)ATC>ATT	p.I464I	USP13_uc003fkf.2_Silent_p.I464I	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	464					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			GGAACCGCATCGGCTCAGAAA	0.448												
VPS8	23355	broad.mit.edu	37	3	184573502	184573502	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:184573502G>T	uc003fpb.1	+	13	1204	c.1033G>T	c.(1033-1035)GAT>TAT	p.D345Y	VPS8_uc010hyd.1_Missense_Mutation_p.D345Y	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	347							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TACTTAGATGGATCCTTCCAG	0.348												
ATP13A5	344905	broad.mit.edu	37	3	193031864	193031864	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:193031864G>A	uc011bsq.1	-	19	2277	c.2277C>T	c.(2275-2277)ACC>ACT	p.T759T		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	759					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CCAGCTGCCAGGTCACAGAGG	0.507												
TNK2	10188	broad.mit.edu	37	3	195594114	195594114	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr3:195594114C>T	uc003fvu.1	-	13	3451	c.2908G>A	c.(2908-2910)GTG>ATG	p.V970M	TNK2_uc003fvq.1_Missense_Mutation_p.V379M|TNK2_uc003fvr.1_Missense_Mutation_p.V497M|TNK2_uc003fvs.1_Intron|TNK2_uc003fvt.1_Intron	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	970	UBA.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	TCTGTGGTCACCCCATGCACC	0.687												
BOD1L	259282	broad.mit.edu	37	4	13606144	13606144	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr4:13606144T>A	uc003gmz.1	-	10	2497	c.2380A>T	c.(2380-2382)AGG>TGG	p.R794W	BOD1L_uc010idr.1_Missense_Mutation_p.R131W	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	794	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						CTTTCATTCCTATGTTTACTT	0.299												
GABRB1	2560	broad.mit.edu	37	4	47427764	47427764	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr4:47427764C>G	uc003gxh.2	+	9	1528	c.1154C>G	c.(1153-1155)ACG>AGG	p.T385R	GABRB1_uc011bze.1_Missense_Mutation_p.T315R	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	385	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GAAGTGCTCACGAGCGTGAGC	0.622												
UGT2B4	7363	broad.mit.edu	37	4	70346533	70346533	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr4:70346533C>T	uc003hek.3	-	6	1453	c.1406G>A	c.(1405-1407)CGC>CAC	p.R469H	UGT2B4_uc011cap.1_Missense_Mutation_p.R333H|UGT2B4_uc003hel.3_3'UTR	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	469					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TCCTTTATGGCGCATGACAAA	0.473												
SULT1B1	27284	broad.mit.edu	37	4	70596360	70596360	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr4:70596360C>T	uc003hen.2	-	7	935	c.637G>A	c.(637-639)GAG>AAG	p.E213K		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	213	PAPS (By similarity).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						AGGTTCTTCTCTAGAAATCTA	0.343												
ARHGAP24	83478	broad.mit.edu	37	4	86491782	86491782	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr4:86491782G>T	uc003hpk.2	+	2	537	c.88G>T	c.(88-90)GGA>TGA	p.G30*	ARHGAP24_uc003hpi.1_Nonsense_Mutation_p.G30*|ARHGAP24_uc003hpj.2_Nonsense_Mutation_p.G30*	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1	30	PH.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		GAGGAAGCAAGGAGGCTTTGT	0.502												
HERC5	51191	broad.mit.edu	37	4	89385112	89385112	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr4:89385112G>A	uc003hrt.2	+	6	1040	c.887G>A	c.(886-888)AGA>AAA	p.R296K		NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	296	RCC1 4.				innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		GTTGGGTATAGAGTGACTCAG	0.373												
ADAD1	132612	broad.mit.edu	37	4	123336756	123336756	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr4:123336756G>T	uc003ieo.2	+	11	1704	c.1472G>T	c.(1471-1473)GGG>GTG	p.G491V	ADAD1_uc003iep.2_Missense_Mutation_p.G480V|ADAD1_uc003ieq.2_Missense_Mutation_p.G473V	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	491	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						GGCCTGAGTGGGAAGATCACT	0.348												
INTU	27152	broad.mit.edu	37	4	128632186	128632186	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr4:128632186C>T	uc003ifk.1	+	14	2558	c.2488C>T	c.(2488-2490)CAG>TAG	p.Q830*	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	830										ovary(1)	1						TATCCACCCTCAGCTAATAAA	0.428												
HSPA4L	22824	broad.mit.edu	37	4	128725170	128725170	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr4:128725170C>G	uc003ifm.2	+	8	1166	c.913C>G	c.(913-915)CAA>GAA	p.Q305E	HSPA4L_uc010iny.1_Missense_Mutation_p.Q264E|HSPA4L_uc011cgr.1_Missense_Mutation_p.Q272E	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	305					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						TCACAGGGCTCAATTTGAACA	0.348												
INPP4B	8821	broad.mit.edu	37	4	143191883	143191883	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr4:143191883A>G	uc003iix.3	-	11	1143	c.548T>C	c.(547-549)GTC>GCC	p.V183A	INPP4B_uc003iiw.3_Missense_Mutation_p.V183A|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_5'UTR|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Missense_Mutation_p.V54A	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	183					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					CATCTTCACGACACTGACTTC	0.453												
CDH18	1016	broad.mit.edu	37	5	19721493	19721493	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:19721493G>A	uc003jgc.2	-	4	983	c.606C>T	c.(604-606)CTC>CTT	p.L202L	CDH18_uc003jgd.2_Silent_p.L202L|CDH18_uc011cnm.1_Silent_p.L202L	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	202	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GTTGTCCTTGGAGAATGCTGT	0.473												
GOLPH3	64083	broad.mit.edu	37	5	32135789	32135789	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:32135789T>C	uc003jhp.1	-	3	646	c.361A>G	c.(361-363)ATC>GTC	p.I121V		NM_022130	NP_071413	Q9H4A6	GOLP3_HUMAN	golgi phosphoprotein 3	121					cell proliferation|positive regulation of TOR signaling cascade|regulation of mitochondrion organization	cytosol|endosome|Golgi cisterna membrane|mitochondrial intermembrane space|plasma membrane|trans-Golgi network	protein binding			ovary(1)	1						GACTTACAGATTACCTAAAAA	0.358												
PRLR	5618	broad.mit.edu	37	5	35086401	35086401	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:35086401A>G	uc003jjm.2	-	4	642	c.112T>C	c.(112-114)TCT>CCT	p.S38P	PRLR_uc003jjg.1_Missense_Mutation_p.S38P|PRLR_uc003jjh.1_Missense_Mutation_p.S38P|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Missense_Mutation_p.S38P|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Intron|PRLR_uc010iuw.1_5'UTR	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	38	Fibronectin type-III 1.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTATTGGGAGAACGACATTTA	0.448												
C5orf44	80006	broad.mit.edu	37	5	64946672	64946672	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:64946672G>C	uc003jtz.3	+	6	794	c.464G>C	c.(463-465)GGA>GCA	p.G155A	C5orf44_uc003jua.3_Missense_Mutation_p.G155A|C5orf44_uc003juc.3_Missense_Mutation_p.G155A|C5orf44_uc010iwv.2_Missense_Mutation_p.G155A	NM_024941	NP_079217	A5PLN9	CE044_HUMAN	hypothetical protein LOC80006 isoform 2	155										ovary(1)	1						ACTCAGGCTGGAGAAAAAATG	0.303												
MAP1B	4131	broad.mit.edu	37	5	71495728	71495728	+	Silent	SNP	C	C	T	rs77733766	byFrequency	TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:71495728C>T	uc003kbw.3	+	5	6787	c.6546C>T	c.(6544-6546)GAC>GAT	p.D2182D	MAP1B_uc010iyw.1_Silent_p.D2199D|MAP1B_uc010iyx.1_Silent_p.D2056D|MAP1B_uc010iyy.1_Silent_p.D2056D	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2182						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		ACTCTGAAGACGAGTCGGAAA	0.597												
FER	2241	broad.mit.edu	37	5	108521949	108521949	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:108521949G>C	uc003kop.1	+	19	2636	c.2252G>C	c.(2251-2253)TGG>TCG	p.W751S	FER_uc011cvg.1_Missense_Mutation_p.W576S	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	751	Protein kinase.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		ATCCTTCTCTGGGAGACCTTC	0.473												
PDLIM4	8572	broad.mit.edu	37	5	131607543	131607543	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:131607543G>C	uc003kwn.2	+	6	807	c.730G>C	c.(730-732)GCT>CCT	p.A244P	uc003kwm.3_Intron|PDLIM4_uc003kwp.2_Intron|PDLIM4_uc003kwo.2_Missense_Mutation_p.A352P	NM_003687	NP_003678	P50479	PDLI4_HUMAN	PDZ and LIM domain 4 isoform 1	244							protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAAGCTGGGCGCTCCGCTGAG	0.726												
CTNNA1	1495	broad.mit.edu	37	5	138269667	138269667	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:138269667G>A	uc003ldh.2	+	18	2705	c.2610G>A	c.(2608-2610)GTG>GTA	p.V870V	CTNNA1_uc011cyx.1_Silent_p.V767V|CTNNA1_uc011cyy.1_Silent_p.V747V|CTNNA1_uc003ldi.2_Silent_p.V568V|CTNNA1_uc003ldj.2_3'UTR|CTNNA1_uc003ldl.2_Silent_p.V500V	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	870					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AGCCATTGGTGAAGAGAGAGA	0.502												
CTNNA1	1495	broad.mit.edu	37	5	138269676	138269676	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:138269676G>C	uc003ldh.2	+	18	2714	c.2619G>C	c.(2617-2619)GAG>GAC	p.E873D	CTNNA1_uc011cyx.1_Missense_Mutation_p.E770D|CTNNA1_uc011cyy.1_Missense_Mutation_p.E750D|CTNNA1_uc003ldi.2_Missense_Mutation_p.E571D|CTNNA1_uc003ldj.2_3'UTR|CTNNA1_uc003ldl.2_Missense_Mutation_p.E503D	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	873					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TGAAGAGAGAGAAACAGGATG	0.493												
PCDHGA2	56113	broad.mit.edu	37	5	140719889	140719889	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:140719889G>A	uc003ljk.1	+	1	1536	c.1351G>A	c.(1351-1353)GCC>ACC	p.A451T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.A451T	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	451	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACGCACCCGCCTTCTCCCG	0.552												
SH3RF2	153769	broad.mit.edu	37	5	145439568	145439568	+	Silent	SNP	C	C	T	rs142262740	by1000genomes	TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:145439568C>T	uc003lnt.2	+	9	1933	c.1695C>T	c.(1693-1695)GCC>GCT	p.A565A	SH3RF2_uc011dbl.1_Silent_p.A565A|SH3RF2_uc011dbm.1_Silent_p.A50A|SH3RF2_uc003lnu.2_Silent_p.A56A|SH3RF2_uc011dbn.1_Silent_p.A56A|SH3RF2_uc011dbo.1_Silent_p.A22A	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	565							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCCCTCAGCCGTGGTGGTGG	0.672												
CSNK1A1	1452	broad.mit.edu	37	5	148885058	148885058	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:148885058G>C	uc003lqx.1	-	9	1438	c.958C>G	c.(958-960)CAA>GAA	p.Q320E	CSNK1A1_uc011dcb.1_Missense_Mutation_p.Q229E|CSNK1A1_uc011dcc.1_Missense_Mutation_p.Q259E|CSNK1A1_uc003lqv.1_Missense_Mutation_p.Q231E|CSNK1A1_uc003lqw.1_Missense_Mutation_p.Q348E|CSNK1A1_uc003lqy.1_Missense_Mutation_p.Q320E|CSNK1A1_uc010jha.1_Missense_Mutation_p.Q320E	NM_001892	NP_001883	P48729	KC1A_HUMAN	casein kinase 1, alpha 1 isoform 2	320					cell division|mitosis|Wnt receptor signaling pathway	centrosome|condensed chromosome kinetochore|cytosol|nuclear speck	ATP binding|protein binding|protein binding|protein serine/threonine kinase activity			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GTGGGGGTTTGGGCCTGCTGA	0.453												
NUDCD2	134492	broad.mit.edu	37	5	162880981	162880981	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:162880981C>G	uc003lze.2	-	4	553	c.466G>C	c.(466-468)GAG>CAG	p.E156Q		NM_145266	NP_660309	Q8WVJ2	NUDC2_HUMAN	NudC domain containing 2	156						intracellular					0	Renal(175;0.000281)	Medulloblastoma(196;0.0207)|all_neural(177;0.0966)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0981)|OV - Ovarian serous cystadenocarcinoma(192;0.183)|Epithelial(171;0.247)		AGTTATTTCTCAAGGTTTGAG	0.358												
TMED9	54732	broad.mit.edu	37	5	177022391	177022391	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:177022391T>G	uc003mhx.2	+	5	685	c.682T>G	c.(682-684)TTC>GTC	p.F228V	TMED9_uc010jko.2_RNA	NM_017510	NP_059980	Q9BVK6	TMED9_HUMAN	transmembrane emp24 protein transport domain	228	Cytoplasmic (Potential).				transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane					0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTCAAGAGCTTCTTTGAAGC	0.582												
ATXN1	6310	broad.mit.edu	37	6	16326666	16326666	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:16326666C>T	uc003nbt.2	-	8	2847	c.1876G>A	c.(1876-1878)GTG>ATG	p.V626M	ATXN1_uc010jpi.2_Missense_Mutation_p.V626M|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	626	Interaction with USP7.|RNA-binding.|AXH.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				ATCACGGCCACGCCCGGGCTA	0.552												
SCAND3	114821	broad.mit.edu	37	6	28543077	28543077	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:28543077T>A	uc003nlo.2	-	3	2023	c.1405A>T	c.(1405-1407)AGC>TGC	p.S469C		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	469	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GAACTCTGGCTTTGGCAGGTC	0.423												
ABCF1	23	broad.mit.edu	37	6	30554043	30554043	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:30554043G>C	uc003nql.2	+	18	1941	c.1846G>C	c.(1846-1848)GAC>CAC	p.D616H	ABCF1_uc003nqm.2_Missense_Mutation_p.D578H|ABCF1_uc010jsb.2_Intron	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	616					inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						CACTTTTCCAGACCCCCCACC	0.597												
DOM3Z	1797	broad.mit.edu	37	6	31938570	31938570	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:31938570C>T	uc003nyo.1	-	3	1159	c.625G>A	c.(625-627)GAG>AAG	p.E209K	DOM3Z_uc003nyp.1_Missense_Mutation_p.E209K|DOM3Z_uc003nyq.1_Intron|DOM3Z_uc003nyr.1_Missense_Mutation_p.E209K|DOM3Z_uc003nys.1_3'UTR|DOM3Z_uc010jtl.1_3'UTR|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank|STK19_uc010jtn.1_5'Flank	NM_005510	NP_005501	O77932	DOM3Z_HUMAN	DOM-3 homolog Z	209							identical protein binding|metal ion binding|nucleotide binding				0						GTGTTAACCTCCCCAGAGGGG	0.622												
BRPF3	27154	broad.mit.edu	37	6	36181868	36181868	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:36181868G>C	uc003olv.3	+	8	2918	c.2694G>C	c.(2692-2694)TTG>TTC	p.L898F	BRPF3_uc010jwb.2_Intron|BRPF3_uc011dtj.1_Intron|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Intron	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	898					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						TGCAACGCTTGCTCAGTGACA	0.542												
C6orf89	221477	broad.mit.edu	37	6	36882162	36882162	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:36882162T>A	uc003omx.2	+	5	790	c.506T>A	c.(505-507)CTG>CAG	p.L169Q	C6orf89_uc003omv.2_Missense_Mutation_p.L63Q|C6orf89_uc003omw.2_Missense_Mutation_p.L176Q|C6orf89_uc011dtr.1_Missense_Mutation_p.L63Q|C6orf89_uc003omy.2_Missense_Mutation_p.L3Q	NM_152734	NP_689947	Q6UWU4	CF089_HUMAN	hypothetical protein LOC221477	169						integral to membrane				ovary(1)	1						GTGATGCTCCTGGAAGACGCC	0.542												
RNF8	9025	broad.mit.edu	37	6	37336407	37336407	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:37336407G>C	uc003onq.3	+	3	581	c.388G>C	c.(388-390)GAG>CAG	p.E130Q	RNF8_uc003onr.3_Missense_Mutation_p.E130Q|RNF8_uc011dtx.1_Missense_Mutation_p.E62Q	NM_003958	NP_003949	O76064	RNF8_HUMAN	ring finger protein 8 isoform 1	130					cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1						AGAAGACTGGGAGACAATATA	0.378												
CD2AP	23607	broad.mit.edu	37	6	47575752	47575752	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:47575752C>G	uc003oyw.2	+	15	2076	c.1620C>G	c.(1618-1620)TGC>TGG	p.C540W		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	540					cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			AAGATACATGCTACTCTCCAA	0.393												
ANKRD6	22881	broad.mit.edu	37	6	90333683	90333683	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:90333683C>T	uc003pni.3	+	12	1466	c.1125C>T	c.(1123-1125)AAC>AAT	p.N375N	ANKRD6_uc003pne.3_Silent_p.N375N|ANKRD6_uc003pnf.3_Silent_p.N340N|ANKRD6_uc011dzy.1_Silent_p.N375N|ANKRD6_uc010kcd.2_Silent_p.N316N|LYRM2_uc010kce.1_Intron|LYRM2_uc003png.2_Intron|ANKRD6_uc003pnh.3_5'UTR|LYRM2_uc010kcf.1_Intron|ANKRD6_uc003pnj.3_5'UTR	NM_014942	NP_055757	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	375							protein binding			ovary(2)|pancreas(1)	3		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		AAAAGAGGAACAGGCATCGGT	0.542												
SLC35F1	222553	broad.mit.edu	37	6	118556701	118556701	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:118556701C>T	uc003pxx.3	+	3	580	c.379C>T	c.(379-381)CGA>TGA	p.R127*		NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	127					transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		AATTTTACGACGAAGATGGTG	0.388												
SAMD3	154075	broad.mit.edu	37	6	130465893	130465893	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:130465893G>C	uc003qbv.2	-	13	1661	c.1335C>G	c.(1333-1335)TGC>TGG	p.C445W	SAMD3_uc003qbx.2_Missense_Mutation_p.C445W|SAMD3_uc003qbw.2_Missense_Mutation_p.C445W	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	445										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		AAGAAAATTCGCAGACCTCCA	0.423												
TNFAIP3	7128	broad.mit.edu	37	6	138192409	138192409	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:138192409G>T	uc003qhr.2	+	2	111	c.45G>T	c.(43-45)ATG>ATT	p.M15I	TNFAIP3_uc003qhs.2_Missense_Mutation_p.M15I	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	15					anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		TGAGCAATATGCGGAAAGCTG	0.403			D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma						OREG0031869	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)
UTRN	7402	broad.mit.edu	37	6	144749929	144749929	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:144749929C>A	uc003qkt.2	+	7	686	c.594C>A	c.(592-594)AGC>AGA	p.S198R	UTRN_uc010khq.1_Missense_Mutation_p.S198R	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	198	CH 2.|Actin-binding.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		ATCTCTTCAGCTGGGATAAAG	0.348												
UTRN	7402	broad.mit.edu	37	6	144749936	144749936	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:144749936A>G	uc003qkt.2	+	7	693	c.601A>G	c.(601-603)AAA>GAA	p.K201E	UTRN_uc010khq.1_Missense_Mutation_p.K201E	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	201	CH 2.|Actin-binding.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CAGCTGGGATAAAGTTGTCAA	0.353												
AKAP12	9590	broad.mit.edu	37	6	151670624	151670624	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:151670624C>T	uc011eep.1	+	4	1338	c.1098C>T	c.(1096-1098)CAC>CAT	p.H366H	AKAP12_uc003qoe.2_Silent_p.H366H|AKAP12_uc003qof.2_Silent_p.H268H|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Silent_p.H261H	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	366	Involved in PKC-binding (Probable).				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		AAAGTGCCCACGAGCCCCGGT	0.562												
MAS1	4142	broad.mit.edu	37	6	160328818	160328818	+	Silent	SNP	T	T	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:160328818T>A	uc003qsz.2	+	1	845	c.831T>A	c.(829-831)CCT>CCA	p.P277P		NM_002377	NP_002368	P04201	MAS_HUMAN	MAS1 oncogene	277	Helical; Name=7; (Potential).				anatomical structure morphogenesis|cell proliferation|protein kinase C signaling cascade	integral to plasma membrane	angiotensin type II receptor activity			ovary(2)|lung(2)	4		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.44e-18)|BRCA - Breast invasive adenocarcinoma(81;5.6e-06)		GCGCCAACCCTTTCATTTACT	0.448												
T	6862	broad.mit.edu	37	6	166580155	166580155	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:166580155G>T	uc003quu.1	-	3	889	c.396C>A	c.(394-396)TTC>TTA	p.F132L	T_uc003qut.1_Missense_Mutation_p.F132L|T_uc003quv.1_Missense_Mutation_p.F132L	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	132	T-box.				anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		AGTGGGCCCCGAAGTTGGGCG	0.657									Chordoma_Familial_Clustering_of			
GPNMB	10457	broad.mit.edu	37	7	23309691	23309691	+	Silent	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:23309691G>C	uc003swc.2	+	9	1523	c.1362G>C	c.(1360-1362)GTG>GTC	p.V454V	GPNMB_uc003swb.2_Silent_p.V442V|GPNMB_uc011jyy.1_Silent_p.V396V|GPNMB_uc011jyz.1_Silent_p.V343V	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	454	Extracellular (Potential).				negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			TGCTGACTGTGAGACGAACCT	0.552												
NOD1	10392	broad.mit.edu	37	7	30491602	30491602	+	Silent	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:30491602G>C	uc003tav.2	-	6	1954	c.1431C>G	c.(1429-1431)GTC>GTG	p.V477V		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	477	NACHT.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						CCTGGGTGAAGACAAAGAGGC	0.692												
SFRP4	6424	broad.mit.edu	37	7	37947099	37947099	+	Silent	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:37947099T>C	uc003tfo.3	-	6	1409	c.1023A>G	c.(1021-1023)ACA>ACG	p.T341T		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	341					brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						TTTTCGGGTTTGTTCTCTTCT	0.512												
INHBA	3624	broad.mit.edu	37	7	41729775	41729775	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:41729775C>T	uc003thq.2	-	2	989	c.754G>A	c.(754-756)GCC>ACC	p.A252T	INHBA_uc003thr.2_Missense_Mutation_p.A252T	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	252					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						ACCAAGCTGGCGCCACTCTCC	0.378										TSP Lung(11;0.080)		
AUTS2	26053	broad.mit.edu	37	7	70227930	70227930	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:70227930G>T	uc003tvw.3	+	7	1560	c.817G>T	c.(817-819)GGT>TGT	p.G273C	AUTS2_uc003tvx.3_Missense_Mutation_p.G273C	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	273										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CAAGATATCGGGTCTAGAGAG	0.537												
AUTS2	26053	broad.mit.edu	37	7	70228154	70228154	+	Missense_Mutation	SNP	G	G	T	rs151096425		TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:70228154G>T	uc003tvw.3	+	7	1784	c.1041G>T	c.(1039-1041)GAG>GAT	p.E347D	AUTS2_uc003tvx.3_Missense_Mutation_p.E347D	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	347								p.E347K(1)		ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GCCCTCCTGAGGCCCAGCTCC	0.677												
RUNDC3B	154661	broad.mit.edu	37	7	87436707	87436707	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:87436707G>A	uc003ujb.2	+	10	1438	c.1027G>A	c.(1027-1029)GAT>AAT	p.D343N	RUNDC3B_uc011khd.1_Missense_Mutation_p.D326N|RUNDC3B_uc011khe.1_Missense_Mutation_p.D326N|RUNDC3B_uc003ujc.2_Intron|RUNDC3B_uc003ujd.2_Intron	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	343										skin(1)	1	Esophageal squamous(14;0.00164)					AAAGAATAATGATTTAAGATC	0.433												
CYP51A1	1595	broad.mit.edu	37	7	91752481	91752481	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:91752481G>A	uc003ulm.3	-	7	1201	c.1039C>T	c.(1039-1041)CAG>TAG	p.Q347*	CYP51A1_uc011khn.1_Nonsense_Mutation_p.Q242*|CYP51A1_uc003uln.3_Nonsense_Mutation_p.Q284*	NM_000786	NP_000777	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A,	341					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity				0	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	ACTGTTTTCTGTTCTAAATAA	0.403												
TECPR1	25851	broad.mit.edu	37	7	97863002	97863002	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:97863002C>G	uc003upg.2	-	11	1608	c.1403G>C	c.(1402-1404)AGG>ACG	p.R468T	TECPR1_uc003uph.1_Missense_Mutation_p.R398T	NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	468						integral to membrane	protein binding			pancreas(1)	1						TCTGGCCTCCCTGCTGCCCTC	0.662												
GAL3ST4	79690	broad.mit.edu	37	7	99757827	99757827	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:99757827C>T	uc003utt.2	-	3	2202	c.1185G>A	c.(1183-1185)GAG>GAA	p.E395E	C7orf43_uc010lgp.2_5'Flank|C7orf43_uc011kjj.1_5'Flank|C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_Silent_p.E395E|GAL3ST4_uc010lgq.2_Silent_p.E333E	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	395	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAGCCCGGAGCTCGGCCACAG	0.607												
PTN	5764	broad.mit.edu	37	7	136939673	136939673	+	Silent	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:136939673G>T	uc003vtq.2	-	2	411	c.48C>A	c.(46-48)GCC>GCA	p.A16A	PTN_uc010lmx.2_Silent_p.A16A|PTN_uc003vtr.1_Silent_p.A16A	NM_002825	NP_002816	P21246	PTN_HUMAN	pleiotrophin	16					nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			upper_aerodigestive_tract(1)|pancreas(1)	2						ATGCCAAGAAGGCAGCTGCAA	0.463												
TAS2R38	5726	broad.mit.edu	37	7	141673474	141673474	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:141673474G>C	uc003vwx.1	-	1	100	c.16C>G	c.(16-18)CGC>GGC	p.R6G		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	6	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					GTGCGGATGCGAGTTAGAGTC	0.448												
REPIN1	29803	broad.mit.edu	37	7	150068727	150068727	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:150068727C>T	uc010lpq.1	+	4	886	c.397C>T	c.(397-399)CTG>TTG	p.L133L	REPIN1_uc003whd.2_Silent_p.L122L|REPIN1_uc010lpr.1_Silent_p.L190L|REPIN1_uc003whc.2_Silent_p.L133L|REPIN1_uc003whe.2_Silent_p.L133L	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	133	C2H2-type 3.				DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			GGCCCTGGTTCTGCATCTGCG	0.637												
GALNTL5	168391	broad.mit.edu	37	7	151711795	151711795	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:151711795C>A	uc003wkp.2	+	8	1316	c.1093C>A	c.(1093-1095)CAA>AAA	p.Q365K	GALNTL5_uc003wkq.2_Missense_Mutation_p.Q116K|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Missense_Mutation_p.Q254K	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	365	Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		CAGTAAGAAACAAACTGGAAA	0.418												
MLL3	58508	broad.mit.edu	37	7	151845953	151845953	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr7:151845953T>G	uc003wla.2	-	52	13278	c.13059A>C	c.(13057-13059)AGA>AGC	p.R4353S	MLL3_uc003wkz.2_Missense_Mutation_p.R3471S|MLL3_uc003wkx.2_Missense_Mutation_p.R511S|MLL3_uc003wky.2_Missense_Mutation_p.R1917S	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4353					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ATTTCATTCCTCTCCATTTTT	0.433			N		medulloblastoma							
FAM86B1	85002	broad.mit.edu	37	8	12043996	12043996	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr8:12043996G>C	uc010lse.2	-	5	550	c.505C>G	c.(505-507)CTC>GTC	p.L169V	FAM66D_uc011kxp.1_Intron|FAM86B1_uc003wvf.3_Intron|FAM86B1_uc003wvi.3_Intron|FAM86B1_uc010lsd.2_Intron|FAM86B1_uc003wvh.3_Intron|FAM86B1_uc011kxq.1_Intron|FAM86B1_uc010lsf.2_Intron|FAM86B1_uc003wvj.3_Missense_Mutation_p.L103V|FAM86B1_uc003wvk.3_Missense_Mutation_p.L203V|FAM86B1_uc010lsg.2_Intron|FAM86B1_uc003wvl.3_Intron	NM_001083537	NP_001077006	Q8N7N1	F86B1_HUMAN	hypothetical protein LOC85002	169											0			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.0965)		AGGCCATTGAGAAGGACATTC	0.597												
POLB	5423	broad.mit.edu	37	8	42202482	42202482	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr8:42202482C>G	uc003xoz.1	+	3	244	c.131C>G	c.(130-132)TCT>TGT	p.S44C	POLB_uc003xpa.1_Missense_Mutation_p.S44C|POLB_uc011lcs.1_Translation_Start_Site	NM_002690	NP_002681	P06746	DPOLB_HUMAN	DNA-directed DNA polymerase beta	44					DNA-dependent DNA replication	cytoplasm|nucleoplasm|spindle microtubule	DNA-(apurinic or apyrimidinic site) lyase activity|DNA-directed DNA polymerase activity|enzyme binding|metal ion binding|microtubule binding			ovary(1)|breast(1)	2	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.18e-11)|Lung(22;0.00467)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|LUSC - Lung squamous cell carcinoma(45;0.024)		Cytarabine(DB00987)	AAAGCAGCATCTGTTATAGCA	0.338								DNA_polymerases_(catalytic_subunits)				
ST18	9705	broad.mit.edu	37	8	53062442	53062442	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr8:53062442G>T	uc003xqz.2	-	11	2058	c.1902C>A	c.(1900-1902)AAC>AAA	p.N634K	ST18_uc011ldq.1_Missense_Mutation_p.N281K|ST18_uc011ldr.1_Missense_Mutation_p.N599K|ST18_uc011lds.1_Missense_Mutation_p.N539K|ST18_uc003xra.2_Missense_Mutation_p.N634K|ST18_uc003xrb.2_Missense_Mutation_p.N634K	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	634						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				GAATAGAAGTGTTAGAGGAAG	0.453												
RRS1	23212	broad.mit.edu	37	8	67342340	67342340	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr8:67342340G>C	uc003xwa.2	+	1	1078	c.974G>C	c.(973-975)GGG>GCG	p.G325A	ADHFE1_uc003xwb.3_5'Flank|ADHFE1_uc003xwd.3_5'Flank|ADHFE1_uc003xwc.3_5'Flank|ADHFE1_uc003xwe.3_5'Flank|ADHFE1_uc003xwf.3_5'Flank|ADHFE1_uc011les.1_5'Flank|ADHFE1_uc011leq.1_5'Flank|ADHFE1_uc011ler.1_5'Flank	NM_015169	NP_055984	Q15050	RRS1_HUMAN	homolog of yeast ribosome biogenesis regulatory	325	Arg/Gly/Lys-rich.				mitotic metaphase plate congression|ribosome biogenesis	condensed nuclear chromosome|nucleolus					0		Lung NSC(129;0.197)	Epithelial(68;0.0391)|all cancers(69;0.0898)|BRCA - Breast invasive adenocarcinoma(89;0.111)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			AAGAGGAAAGGGGGCCCGCCC	0.642												
STK3	6788	broad.mit.edu	37	8	99761538	99761538	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr8:99761538G>A	uc003yip.2	-	4	458	c.317C>T	c.(316-318)TCT>TTT	p.S106F	STK3_uc003yio.2_Missense_Mutation_p.S134F|STK3_uc010mbm.1_Missense_Mutation_p.S106F	NM_006281	NP_006272	Q13188	STK3_HUMAN	serine/threonine kinase 3	106	Protein kinase.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		GTCTGAGACAGAGCCAGCGCC	0.318												
ZHX2	22882	broad.mit.edu	37	8	123966231	123966231	+	Silent	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr8:123966231C>T	uc003ypk.1	+	3	3048	c.2481C>T	c.(2479-2481)TCC>TCT	p.S827S		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	827						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			AATCAGACTCCGACTGCGTCC	0.587												
FAM83A	84985	broad.mit.edu	37	8	124219604	124219604	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr8:124219604T>G	uc003ypv.2	+	5	2995	c.981T>G	c.(979-981)AGT>AGG	p.S327R	FAM83A_uc003ypw.2_Missense_Mutation_p.S327R|FAM83A_uc003ypy.2_Missense_Mutation_p.S271R|FAM83A_uc003ypx.2_Missense_Mutation_p.S327R|FAM83A_uc003ypz.2_Missense_Mutation_p.S327R	NM_032899	NP_116288	Q86UY5	FA83A_HUMAN	hypothetical protein LOC84985 isoform a	327	Ser-rich.									ovary(3)|skin(1)	4	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GCTCCGCCAGTGACCGCACGT	0.731												
ATAD2	29028	broad.mit.edu	37	8	124359446	124359446	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr8:124359446C>T	uc003yqh.3	-	16	2206	c.2098G>A	c.(2098-2100)GCA>ACA	p.A700T	ATAD2_uc011lii.1_Missense_Mutation_p.A491T|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.A700T	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	700					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GTGGACAGTGCCTGCCCAGGT	0.438												
TG	7038	broad.mit.edu	37	8	133980211	133980211	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr8:133980211G>T	uc003ytw.2	+	31	5900	c.5859G>T	c.(5857-5859)AAG>AAT	p.K1953N	TG_uc010mdw.2_Missense_Mutation_p.K712N|TG_uc011ljb.1_Missense_Mutation_p.K322N|TG_uc011ljc.1_Missense_Mutation_p.K107N|TG_uc010mdx.1_RNA	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1953	Type IIIA.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TGTTCCGGAAGAAAGGTGAGC	0.473												
ZC3H3	23144	broad.mit.edu	37	8	144620387	144620387	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr8:144620387G>A	uc003yyd.2	-	2	1179	c.1150C>T	c.(1150-1152)CCC>TCC	p.P384S		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	384	Poly-Ser.				mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			GAGGCAGAGGGGCTGGAGGCC	0.657												
CDC37L1	55664	broad.mit.edu	37	9	4697116	4697116	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:4697116G>C	uc003zio.2	+	4	739	c.529G>C	c.(529-531)GAT>CAT	p.D177H		NM_017913	NP_060383	Q7L3B6	CD37L_HUMAN	cell division cycle 37 homolog (S.	177	Self-association and interaction with Hsp90.					cytoplasm					0	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0318)		TCGATGGGATGATAGCCAGAG	0.343												
RANBP6	26953	broad.mit.edu	37	9	6013104	6013104	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:6013104G>C	uc003zjr.2	-	1	2515	c.2504C>G	c.(2503-2505)TCT>TGT	p.S835C	RANBP6_uc011lmf.1_Missense_Mutation_p.S483C|RANBP6_uc003zjs.2_Missense_Mutation_p.S423C	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	835	Potential.				protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ATCTTGCAGAGACATCTCAAC	0.348												
SH3GL2	6456	broad.mit.edu	37	9	17795579	17795579	+	Silent	SNP	C	C	T	rs143422821		TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:17795579C>T	uc003zna.2	+	9	1185	c.897C>T	c.(895-897)TAC>TAT	p.Y299Y	SH3GL2_uc011lmy.1_Silent_p.Y252Y	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	299	SH3.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		GAGCTCTGTACGACTTTGAAC	0.463												
GRIN3A	116443	broad.mit.edu	37	9	104433073	104433073	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:104433073G>T	uc004bbp.1	-	3	2222	c.1621C>A	c.(1621-1623)CAA>AAA	p.Q541K	GRIN3A_uc004bbq.1_Missense_Mutation_p.Q541K	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	541	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	AGACAGAGTTGGCCAGCAGGG	0.458												
PTGR1	22949	broad.mit.edu	37	9	114348359	114348359	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:114348359C>G	uc004bfh.2	-	5	399	c.296G>C	c.(295-297)GGG>GCG	p.G99A	PTGR1_uc011lwr.1_Missense_Mutation_p.G99A|PTGR1_uc004bfi.3_Missense_Mutation_p.G99A|PTGR1_uc004bfj.3_5'UTR|PTGR1_uc010mue.2_Missense_Mutation_p.G99A	NM_012212	NP_036344	Q14914	PTGR1_HUMAN	prostaglandin reductase 1 isoform 1	99					leukotriene metabolic process	cytoplasm	15-oxoprostaglandin 13-oxidase activity|2-alkenal reductase activity|alcohol dehydrogenase (NAD) activity|zinc ion binding				0						CAGATCTTTCCCATCAGAAAT	0.463												
PHF19	26147	broad.mit.edu	37	9	123620386	123620386	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:123620386C>T	uc004bks.1	-	15	1832	c.1579G>A	c.(1579-1581)GAA>AAA	p.E527K	PHF19_uc011lyf.1_Missense_Mutation_p.E318K|PHF19_uc004bkr.2_RNA	NM_015651	NP_056466	Q5T6S3	PHF19_HUMAN	PHD finger protein 19 isoform a	527					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|breast(1)	2						GAGTCATCTTCACTGATGCTC	0.587												
PHF19	26147	broad.mit.edu	37	9	123620439	123620439	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:123620439A>T	uc004bks.1	-	15	1779	c.1526T>A	c.(1525-1527)GTC>GAC	p.V509D	PHF19_uc011lyf.1_Missense_Mutation_p.V300D|PHF19_uc004bkr.2_RNA	NM_015651	NP_056466	Q5T6S3	PHF19_HUMAN	PHD finger protein 19 isoform a	509					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|breast(1)	2						CCGCTCGGGGACTGAAGCCCC	0.592												
LHX2	9355	broad.mit.edu	37	9	126794769	126794769	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:126794769A>T	uc004boe.1	+	5	1743	c.1004A>T	c.(1003-1005)AAG>ATG	p.K335M	LHX2_uc010mwi.1_Missense_Mutation_p.K343M	NM_004789	NP_004780	P50458	LHX2_HUMAN	LIM homeobox protein 2	335						nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGCGTGGACAAGTCGACAGAC	0.672												
MAPKAP1	79109	broad.mit.edu	37	9	128246724	128246724	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:128246724A>G	uc004bpv.2	-	9	1538	c.1205T>C	c.(1204-1206)CTA>CCA	p.L402P	MAPKAP1_uc011lzt.1_Missense_Mutation_p.L205P|MAPKAP1_uc010mwz.2_RNA|MAPKAP1_uc011lzu.1_Missense_Mutation_p.L205P|MAPKAP1_uc011lzv.1_Missense_Mutation_p.L110P|MAPKAP1_uc004bpw.2_Missense_Mutation_p.L210P|MAPKAP1_uc004bpx.2_Missense_Mutation_p.L210P|MAPKAP1_uc004bpy.2_Missense_Mutation_p.L366P|MAPKAP1_uc004bpz.2_Intron|MAPKAP1_uc010mxa.2_RNA	NM_001006617	NP_001006618	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated	402					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			ovary(2)|lung(2)	4						ACACTTACCTAGCTGTACGTC	0.448												
CERCAM	51148	broad.mit.edu	37	9	131186865	131186865	+	Silent	SNP	C	C	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:131186865C>A	uc004buz.3	+	5	1136	c.738C>A	c.(736-738)ATC>ATA	p.I246I	CERCAM_uc004buy.1_Silent_p.I168I|CERCAM_uc010mxz.2_Silent_p.I168I|CERCAM_uc010mya.1_Silent_p.I87I	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	246					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						ACGACATCATCGTCTTCGCCT	0.473												
GTF3C5	9328	broad.mit.edu	37	9	135932246	135932246	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:135932246G>A	uc004cci.3	+	10	1681	c.1344G>A	c.(1342-1344)AGG>AGA	p.R448R	GTF3C5_uc004ccj.3_Silent_p.R455R	NM_012087	NP_036219	Q9Y5Q8	TF3C5_HUMAN	general transcription factor IIIC, polypeptide 5	448						transcription factor TFIIIC complex	DNA binding|protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.01e-06)|Epithelial(140;4e-05)		ACGAGCTCAGGGACACCATGT	0.597												
FCN2	2220	broad.mit.edu	37	9	137778399	137778399	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:137778399A>T	uc004cfg.1	+	7	693	c.683A>T	c.(682-684)GAG>GTG	p.E228V	FCN2_uc004cfh.1_Missense_Mutation_p.E190V	NM_004108	NP_004099	Q15485	FCN2_HUMAN	ficolin 2 isoform a precursor	228	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			large_intestine(1)	1		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		GCCTTCGTGGAGGGCAGTGCG	0.557												
CAMSAP1	157922	broad.mit.edu	37	9	138712788	138712788	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:138712788T>G	uc004cgr.3	-	11	3719	c.3719A>C	c.(3718-3720)GAC>GCC	p.D1240A	CAMSAP1_uc004cgq.3_Missense_Mutation_p.D1130A|CAMSAP1_uc010nbg.2_Missense_Mutation_p.D962A	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	1240						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GGCCTTCAGGTCGGAGAGGTC	0.642												
UBAC1	10422	broad.mit.edu	37	9	138825266	138825266	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:138825266G>A	uc004cgt.2	-	10	1416	c.1198C>T	c.(1198-1200)CAG>TAG	p.Q400*	UBAC1_uc004cgs.1_Intron|UBAC1_uc004cgu.2_RNA	NM_016172	NP_057256	Q9BSL1	UBAC1_HUMAN	ubiquitin associated domain containing 1	400						Golgi apparatus|plasma membrane	protein binding			skin(2)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.1e-06)|Epithelial(140;7.79e-06)		TTTAGTGTCTGGAAGATTCTA	0.572												
MAN1B1	11253	broad.mit.edu	37	9	139995507	139995507	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:139995507G>T	uc004cld.2	+	7	1002	c.967G>T	c.(967-969)GAC>TAC	p.D323Y	MAN1B1_uc004clc.2_Missense_Mutation_p.D224Y|MAN1B1_uc011meo.1_Missense_Mutation_p.D224Y|MAN1B1_uc011mep.1_Missense_Mutation_p.D323Y|MAN1B1_uc010ncc.2_RNA|MAN1B1_uc004clf.1_5'Flank	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	323	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		CTTTGAAAAGGACGTGGACGT	0.512												
PNPLA7	375775	broad.mit.edu	37	9	140435144	140435144	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr9:140435144G>A	uc004cnf.2	-	7	959	c.622C>T	c.(622-624)CTG>TTG	p.L208L	PNPLA7_uc010ncj.1_Silent_p.L233L	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	208	cNMP 1.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		TCTCCCGCCAGAACCTCTTTC	0.701												
FAM9B	171483	broad.mit.edu	37	X	8995918	8995918	+	Silent	SNP	T	T	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chrX:8995918T>C	uc011mhu.1	-	6	572	c.483A>G	c.(481-483)CAA>CAG	p.Q161Q	FAM9B_uc011mhv.1_RNA|FAM9B_uc004csh.2_Silent_p.Q201Q	NM_205849	NP_995321	Q8IZU0	FAM9B_HUMAN	family with sequence similarity 9, member B	161						nucleus					0		Hepatocellular(5;0.219)				CCTTTACGAATTGGTCACGTA	0.363												
ARHGAP6	395	broad.mit.edu	37	X	11162130	11162130	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chrX:11162130C>T	uc004cup.1	-	11	3019	c.2146G>A	c.(2146-2148)GAA>AAA	p.E716K	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.E716K|ARHGAP6_uc004cum.1_Missense_Mutation_p.E513K|ARHGAP6_uc004cun.1_Missense_Mutation_p.E536K|ARHGAP6_uc010neb.1_Missense_Mutation_p.E538K|ARHGAP6_uc011mif.1_3'UTR	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	716					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						GGAGAACTTTCCCTTGACTTT	0.592											OREG0019666	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
IL1RAPL1	11141	broad.mit.edu	37	X	29301315	29301315	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chrX:29301315C>T	uc004dby.2	+	3	851	c.343C>T	c.(343-345)CTC>TTC	p.L115F		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	115	Ig-like C2-type 1.|Extracellular (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						GGACAGTGGTCTCTACGCCTG	0.438												
WDR13	64743	broad.mit.edu	37	X	48460231	48460231	+	Silent	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chrX:48460231G>A	uc004dkh.1	+	7	1038	c.891G>A	c.(889-891)AAG>AAA	p.K297K	WDR13_uc010nif.1_Silent_p.K175K|WDR13_uc004dki.1_Silent_p.K205K|WDR13_uc004dkj.1_Silent_p.K297K|WDR13_uc004dkk.1_Silent_p.K205K|WDR13_uc004dkl.3_Silent_p.K205K	NM_017883	NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13 protein	297						cytoplasm|nucleus				ovary(2)	2						AGAAAGTGAAGGGGGGCTCCA	0.582												
GATA1	2623	broad.mit.edu	37	X	48651642	48651642	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chrX:48651642C>T	uc004dkq.3	+	5	899	c.808C>T	c.(808-810)CGG>TGG	p.R270W		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	270	GATA-type 2.				basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						GACACTGTGGCGGAGAAATGC	0.602			Mis|F		megakaryoblastic leukemia of Downs Syndrome							
PGK1	5230	broad.mit.edu	37	X	77378856	77378856	+	Silent	SNP	A	A	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chrX:77378856A>T	uc004ecz.3	+	8	1093	c.921A>T	c.(919-921)ATA>ATT	p.I307I	PGK1_uc010nlz.2_RNA|PGK1_uc011mqq.1_Silent_p.I279I	NM_000291	NP_000282	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	307					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			upper_aerodigestive_tract(1)|ovary(1)	2						CTTCTGGCATACCTGCTGGCT	0.463												
CYLC1	1538	broad.mit.edu	37	X	83129174	83129174	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chrX:83129174G>A	uc004eei.1	+	4	1479	c.1458G>A	c.(1456-1458)ATG>ATA	p.M486I	CYLC1_uc004eeh.1_Missense_Mutation_p.M485I	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	486	6.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						CTACTGAAATGGAATCTGATT	0.338												
ZNF711	7552	broad.mit.edu	37	X	84526498	84526498	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chrX:84526498G>C	uc004eeo.2	+	9	2297	c.1950G>C	c.(1948-1950)AGG>AGC	p.R650S	ZNF711_uc004eep.2_Missense_Mutation_p.R650S|ZNF711_uc004eeq.2_Missense_Mutation_p.R696S|ZNF711_uc011mqy.1_Missense_Mutation_p.R249S	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	650	C2H2-type 9.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						ATCAGTGCAGGCACTGTGACT	0.393												
AFF2	2334	broad.mit.edu	37	X	148037909	148037909	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chrX:148037909T>A	uc004fcp.2	+	11	2813	c.2334T>A	c.(2332-2334)TTT>TTA	p.F778L	AFF2_uc004fcq.2_Missense_Mutation_p.F768L|AFF2_uc004fcr.2_Missense_Mutation_p.F739L|AFF2_uc011mxb.1_Missense_Mutation_p.F743L|AFF2_uc004fcs.2_Missense_Mutation_p.F745L|AFF2_uc011mxc.1_Missense_Mutation_p.F419L	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	778					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					AGCCAACATTTTCACCTATTC	0.453												
HDLBP	3069	broad.mit.edu	37	2	242186472	242186473	+	Splice_Site	INS	-	-	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:242186471_242186472C>CT	uc002waz.3	-	15	1991	c.1818_splice	c.e15+1	p.K606_splice	HDLBP_uc002wba.3_Splice_Site_p.K606_splice|HDLBP_uc021vzg.1_Splice_Site_p.K573_splice	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	Homo sapiens high density lipoprotein binding protein (HDLBP), transcript variant 2, mRNA.	606	KH 7.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	RNA binding|lipid binding|protein binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		AAGTTATCACCTTTTTAATGTT	0.401												
HEATR7B2	133558	broad.mit.edu	37	5	41033143	41033144	+	Splice_Site	INS	-	-	CAAT			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:41033142_41033143C>CCAAT	uc003jmj.4	-	23	2851	c.2361_splice	c.e23+1	p.L787_splice	HEATR7B2_uc003jmi.4_Splice_Site_p.L342_splice	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	Homo sapiens HEAT repeat family member 7B2 (HEATR7B2), mRNA.	787							binding			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|liver(1)|lung(81)|ovary(6)|pancreas(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(4)	133						TGCACACTCACCAGCATGTAAC	0.446												
RCN1	5954	broad.mit.edu	37	11	32124954	32124972	+	Frame_Shift_Del	DEL	GATCCTCCCTCAAGATTAT	GATCCTCCCTCAAGATTAT	-	rs139483311	byFrequency	TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr11:32124954_32124972delGATCCTCCCTCAAGATTAT	uc010reb.1	+	5	1082_1100	c.816_834delGATCCTCCCTCAAGATTAT	c.(814-834)TGGATCCTCCCTCAAGATTATfs	p.W272fs	RCN1_uc010rea.1_Frame_Shift_Del_p.W221fs|RCN1_uc001mtk.2_Frame_Shift_Del_p.W106fs	NM_002901	NP_002892	Q15293	RCN1_HUMAN	reticulocalbin 1 precursor	272_278	EF-hand 5.					endoplasmic reticulum lumen	calcium ion binding			large_intestine(1)	1	Lung SC(675;0.225)					TTCGCCACTGGATCCTCCCTCAAGATTATGATCATGCAC	0.461												
RNF43	54894	broad.mit.edu	37	17	56440698	56440720	+	Frame_Shift_Del	DEL	CCATCAGCTTCTCAGCGTCATTA	CCATCAGCTTCTCAGCGTCATTA	-	rs145164323		TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:56440698_56440720delCCATCAGCTTCTCAGCGTCATTA	uc002iwf.2	-	4	2454_2476	c.498_520delTAATGACGCTGAGAAGCTGATGG	c.(496-522)GGTAATGACGCTGAGAAGCTGATGGAGfs	p.G166fs	RNF43_uc010wnv.1_Frame_Shift_Del_p.G125fs|RNF43_uc002iwh.3_Frame_Shift_Del_p.G166fs|RNF43_uc002iwg.3_Frame_Shift_Del_p.G166fs|RNF43_uc010dcw.2_Frame_Shift_Del_p.G39fs	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	166_174	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TACACAAACTCCATCAGCTTCTCAGCGTCATTACCCCAGATCA	0.583												
MYT1L	23040	broad.mit.edu	37	2	1926074	1926075	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:1926074_1926075insT	uc002qxe.2	-	10	2293_2294	c.1466_1467insA	c.(1465-1467)AAGfs	p.K489fs	MYT1L_uc002qxd.2_Frame_Shift_Ins_p.K489fs|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	489					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CATAGTATGGCTTTTTGACATG	0.450												
HDLBP	3069	broad.mit.edu	37	2	242186471	242186472	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:242186471_242186472insT	uc002waz.2	-	15	2045_2046	c.1817_1818insA	c.(1816-1818)AAGfs	p.K606fs	HDLBP_uc002wba.2_Frame_Shift_Ins_p.K606fs|HDLBP_uc002wbb.2_Frame_Shift_Ins_p.K558fs	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	606	KH 7.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		AAGTTATCACCTTTTTAATGTT	0.401												
RSPH1	89765	broad.mit.edu	37	21	43916250	43916257	+	Frame_Shift_Del	DEL	TCATTCTC	TCATTCTC	-			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr21:43916250_43916257delTCATTCTC	uc002zbg.2	-	1	145_152	c.40_47delGAGAATGA	c.(40-48)GAGAATGATfs	p.E14fs	SLC37A1_uc002zbh.1_RNA	NM_080860	NP_543136	Q8WYR4	RSPH1_HUMAN	testis-specific gene A2	14_16					meiosis	cytosol|nucleus				ovary(1)	1						CACCCCAATATCATTCTCTCCCTCCTCC	0.635												
OR11H1	81061	broad.mit.edu	37	22	16448951	16448952	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr22:16448951_16448952insT	uc011agd.1	-	1	853_854	c.853_854insA	c.(853-855)ATGfs	p.M285fs		NM_001005239	NP_001005239	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H,	285	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		AATTTTCTGCATCCCTGTAGAA	0.465												
TRPS1	7227	broad.mit.edu	37	8	116616365	116616373	+	In_Frame_Del	DEL	AGAGTGCAC	AGAGTGCAC	-			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr8:116616365_116616373delAGAGTGCAC	uc003ynz.2	-	3	2243_2251	c.1784_1792delGTGCACTCT	c.(1783-1794)TGTGCACTCTTG>TTG	p.CAL595del	TRPS1_uc011lhy.1_In_Frame_Del_p.CAL599del|TRPS1_uc003yny.2_In_Frame_Del_p.CAL608del|TRPS1_uc010mcy.2_In_Frame_Del_p.CAL595del	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	595_597					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TGCAGAAGCAAGAGTGCACAGTGGGAACA	0.483									Langer-Giedion_syndrome			
MACF1	23499	broad.mit.edu	37	1	39801326	39801342	+	Frame_Shift_Del	DEL	AAGTGAAAAAGGGAAAG	AAGTGAAAAAGGGAAAG	-			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr1:39801325_39801341CAAGTGAAAAAGGGAAAG>C	uc021olw.1	+	0	4385_4401	c.4385_4401CAAGTGAAAAAGGGAAAG>C	c.(4384-4401)tcaagtgaaaaagggaaafs	p.S1462fs	MACF1_uc021ols.1_Intron|MACF1_uc001cdc.2_Intron|MACF1_uc021olt.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdb.1_Intron	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	Homo sapiens microtubule-actin crosslinking factor 1 (MACF1), transcript variant 1, mRNA.	3027					Golgi to plasma membrane protein transport|Wnt receptor signaling pathway|cell cycle arrest|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|wound healing	Golgi apparatus|microtubule|ruffle membrane	ATPase activity|actin filament binding|calcium ion binding|microtubule binding	p.K1465K(2)		breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAATGACCTCAAGTGAAAAAGGGAAAGAAGCTGATA	0.373												
MYT1L	23040	broad.mit.edu	37	2	1926075	1926076	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:1926074_1926075C>CT	uc002qxe.3	-	9	2293_2294	c.1466_1467G>AG	c.(1465-1467)aagfs	p.K489fs	MYT1L_uc002qxd.3_Frame_Shift_Ins_p.K489fs|MYT1L_uc010ewl.2_Non-coding_Transcript	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	Homo sapiens myelin transcription factor 1-like (MYT1L), mRNA.	489					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CATAGTATGGCTTTTTGACATG	0.450												
TTN	7273	broad.mit.edu	37	2	179471980	179471980	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:179471979_179471979TA>T	uc021vsy.1	-	226	45871	c.45646_45646TA>A	c.(45646-45648)aacfs	p.N15216fs	MIR548N_uc021vsx.1_Intron|LOC100506866_uc002ump.2_Intron|TTN_uc021vsz.1_Frame_Shift_Del_p.N8911fs|TTN_uc021vta.1_Frame_Shift_Del_p.N8844fs|TTN_uc021vtb.1_Frame_Shift_Del_p.N8719fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	Homo sapiens titin (TTN), transcript variant N2-A, mRNA.	16143	Fibronectin type-III 11.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGACCAGTTAAGTAGACAC	0.363												
HDLBP	3069	broad.mit.edu	37	2	242186472	242186473	+	Splice_Site	INS	-	-	T			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr2:242186471_242186472C>CT	uc002waz.3	-	15	1991	c.1818_splice	c.e15+1	p.K606_splice	HDLBP_uc002wba.3_Splice_Site_p.K606_splice|HDLBP_uc021vzg.1_Splice_Site_p.K573_splice	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	Homo sapiens high density lipoprotein binding protein (HDLBP), transcript variant 2, mRNA.	606	KH 7.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	RNA binding|lipid binding|protein binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		AAGTTATCACCTTTTTAATGTT	0.401												
PCDH7	5099	broad.mit.edu	37	4	30724156	30724164	+	In_Frame_Del	DEL	ACCGGATCG	ACCGGATCG	-	rs115429836	byFrequency	TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr4:30724155_30724163CACCGGATCG>C	uc003gsk.1	+	0	2119_2127	c.1111_1119CACCGGATCG>C	c.(1111-1119)caccggatc>C	p.HRI371del	PCDH7_uc011bxx.2_In_Frame_Del_p.HRI371del|PCDH7_uc021xnd.1_In_Frame_Del_p.HRI371del|PCDH7_uc021xnc.1_In_Frame_Del_p.HRI371del	NM_002589	NP_002580	O60245	PCDH7_HUMAN	Homo sapiens protocadherin 7 (PCDH7), transcript variant a, mRNA.	371	Cadherin 3.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						CAGCGTCCTGCACCGGATCGACCGCGAGG	0.675												
FAT4	79633	broad.mit.edu	37	4	126237620	126237629	+	Frame_Shift_Del	DEL	TCTATCAGTA	TCTATCAGTA	-			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr4:126237619_126237628CTCTATCAGTA>C	uc003ifj.4	+	0	53_62	c.53_62CTCTATCAGTA>C	c.(52-63)actctatcagtafs	p.T18fs		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	Homo sapiens FAT tumor suppressor homolog 4 (Drosophila) (FAT4), mRNA.	18					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCGTTGCACACTCTATCAGTATCTCAGCTC	0.586											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
HEATR7B2	133558	broad.mit.edu	37	5	41033143	41033144	+	Splice_Site	INS	-	-	CAAT			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr5:41033142_41033143C>CCAAT	uc003jmj.4	-	23	2851	c.2361_splice	c.e23+1	p.L787_splice	HEATR7B2_uc003jmi.4_Splice_Site_p.L342_splice	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	Homo sapiens HEAT repeat family member 7B2 (HEATR7B2), mRNA.	787							binding			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|liver(1)|lung(81)|ovary(6)|pancreas(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(4)	133						TGCACACTCACCAGCATGTAAC	0.446												
NUP153	9972	broad.mit.edu	37	6	17675805	17675822	+	In_Frame_Del	DEL	ATCATGCTGAGAGGTAGA	ATCATGCTGAGAGGTAGA	-	rs145527673		TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:17675804_17675821CATCATGCTGAGAGGTAGA>C	uc003ncd.1	-	2	715_732	c.515_532TCTACCTCTCAGCATGATG>G	c.(514-534)tctacctctcagcatgatgat>tGat	p.172_178STSQHDD>*	NUP153_uc011dje.1_In_Frame_Del_p.172_178STSQHDD>*|NUP153_uc010jpl.1_In_Frame_Del_p.172_178STSQHDD>*	NM_005124	NP_005115	P49790	NU153_HUMAN	Homo sapiens nucleoporin 153kDa (NUP153), mRNA.	172					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			ATGTTATCATCATCATGCTGAGAGGTAGAATCTTTAAT	0.390												
LY6G6C	80740	broad.mit.edu	37	6	31686912	31686913	+	Frame_Shift_Ins	INS	-	-	A			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr6:31686911_31686912T>TA	uc003nwh.3	-	2	394_395	c.339_340A>TA	c.(337-342)cttaccfs	p.L113fs	LY6G6C_uc010jtd.3_Non-coding_Transcript	NM_025261	NP_079537	O95867	LY66C_HUMAN	Homo sapiens lymphocyte antigen 6 complex, locus G6C (LY6G6C), mRNA.	113						anchored to membrane|plasma membrane				NS(1)|large_intestine(1)|lung(1)|skin(1)	4						GCCAAGGAGGTAAGGAAGACAA	0.614												
PAPSS2	9060	broad.mit.edu	37	10	89501024	89501040	+	Frame_Shift_Del	DEL	TGGAGACCTTCAGGTGC	TGGAGACCTTCAGGTGC	-	rs113541817		TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr10:89501023_89501039GTGGAGACCTTCAGGTGC>G	uc001kex.3	+	8	1366_1382	c.1103_1119GTGGAGACCTTCAGGTGC>G	c.(1102-1119)ggtggagaccttcaggtgfs	p.G368fs	PAPSS2_uc001kew.3_Frame_Shift_Del_p.G373fs	NM_004670	NP_004661	O95340	PAPS2_HUMAN	Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 1, mRNA.	368					3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	ATP binding|adenylylsulfate kinase activity|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	20		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		TGGCTGGTTGGTGGAGACCTTCAGGTGCTGGAGAAAA	0.401												
INHBC	3626	broad.mit.edu	37	12	57828874	57828875	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr12:57828873_57828874CAG>C	uc001snv.1	+	0	331_332	c.204_205CAG>C	c.(202-207)tccagafs	p.S68fs		NM_005538	NP_005529	P55103	INHBC_HUMAN	Homo sapiens inhibin, beta C (INHBC), mRNA.	68					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						GCCCTGTGTCCAGAGCTGCTTT	0.574												
GCN1L1	10985	broad.mit.edu	37	12	120586045	120586071	+	In_Frame_Del	DEL	TGGGAGTCGGTCAGCACCTCCGTAAGC	TGGGAGTCGGTCAGCACCTCCGTAAGC	-			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr12:120586044_120586070ATGGGAGTCGGTCAGCACCTCCGTAAGC>A	uc001txo.3	-	36	4640_4666	c.4627_4653GCTTACGGAGGTGCTGACCGACTCCCAT>T	c.(4627-4653)cttacggaggtgctgaccgactcccat>T	p.LTEVLTDSH1543del		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	Homo sapiens GCN1 general control of amino-acid synthesis 1-like 1 (yeast) (GCN1L1), mRNA.	1543					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding	p.K1542Q(1)		NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGACTTTGACATGGGAGTCGGTCAGCACCTCCGTAAGCTTGGGCACA	0.577												
BRCA2	675	broad.mit.edu	37	13	32913837	32913838	+	Frame_Shift_Ins	INS	-	-	A	rs80358757		TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr13:32913836_32913837C>CA	uc001uub.1	+	10	5571_5572	c.5344_5345C>CA	c.(5344-5346)caafs	p.Q1782fs		NM_000059	NP_000050	P51587	BRCA2_HUMAN	Homo sapiens breast cancer 2, early onset (BRCA2), mRNA.	1782					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|gamma-tubulin binding|protease binding|single-stranded DNA binding	p.N1784fs*7(1)		NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TGTTGAAGATCAAAAAAACACT	0.322			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)		
EIF2AK4	440275	broad.mit.edu	37	15	40268999	40269000	+	In_Frame_Ins	INS	-	-	GACGAC			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr15:40268998_40268999G>GGACGAC	uc001zkm.1	+	11	2252_2253	c.2202_2203G>GGACGAC	c.(2200-2205)gaggac>gaGGACGACac	p.737_738insD	EIF2AK4_uc010bbj.1_In_Frame_Ins_p.466_467insD	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	Homo sapiens eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4), mRNA.	737	Protein kinase 2.				translation	cytosolic ribosome	ATP binding|aminoacyl-tRNA ligase activity|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		GCGATGACGAGGACGACGACGA	0.678												
CYB5D2	124936	broad.mit.edu	37	17	4057987	4058011	+	Frame_Shift_Del	DEL	CTACGGAGAGGATGGGCTGCCCACC	CTACGGAGAGGATGGGCTGCCCACC	-	rs144648688	byFrequency	TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:4057986_4058010TCTACGGAGAGGATGGGCTGCCCACC>T	uc002fxm.4	+	2	998_1022	c.410_434TCTACGGAGAGGATGGGCTGCCCACC>T	c.(409-435)ttctacggagaggatgggctgcccaccfs	p.F137fs	CYB5D2_uc002fxl.4_Frame_Shift_Del_p.F25fs|CYB5D2_uc010cko.3_Frame_Shift_Del_p.F25fs	NM_144611	NP_001241685	Q8WUJ1	NEUFC_HUMAN	Homo sapiens cytochrome b5 domain containing 2 (CYB5D2), transcript variant 1, mRNA.	137					nervous system development	extracellular region	heme binding			breast(1)|large_intestine(3)|liver(2)|ovary(1)	7						ACAGGACGGTTCTACGGAGAGGATGGGCTGCCCACCCCGGCACTG	0.591												
KIAA0100	9703	broad.mit.edu	37	17	26960977	26960983	+	Frame_Shift_Del	DEL	AAGCCCC	AAGCCCC	-			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:26960976_26960982GAAGCCCC>G	uc002hbu.3	-	16	3296_3302	c.3193_3199GGGGCTTC>C	c.(3193-3201)gggcttccgfs	p.G1065fs		NM_014680	NP_055495	Q14667	K0100_HUMAN	Homo sapiens KIAA0100 (KIAA0100), mRNA.	1065						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					TTACCCCACGGAAGCCCCAAGTGCAAG	0.565												
KAT2A	2648	broad.mit.edu	37	17	40271704	40271708	+	Frame_Shift_Del	DEL	ACTAA	ACTAA	-			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:40271703_40271707GACTAA>G	uc002hyx.2	-	4	789_793	c.729_733TTAGTC>C	c.(727-735)tttagtcacfs	p.F243fs		NM_021078	NP_066564	Q92830	KAT2A_HUMAN	Homo sapiens K(lysine) acetyltransferase 2A (KAT2A), mRNA.	243					chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						GGAGCCAGGTGACTAAACTTGTACT	0.541												
MED13	9969	broad.mit.edu	37	17	60042423	60042452	+	In_Frame_Del	DEL	CCCAGCTGTCTGTAGAGCTGATGTCTGTTG	CCCAGCTGTCTGTAGAGCTGATGTCTGTTG	-	rs9907648	by1000genomes	TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr17:60042422_60042451TCCCAGCTGTCTGTAGAGCTGATGTCTGTTG>T	uc002izo.3	-	19	4837_4866	c.4760_4789CAACAGACATCAGCTCTACAGACAGCTGGGA>A	c.(4759-4791)caacagacatcagctctacagacagctgggatt>cAtt	p.1587_1597QQTSALQTAGI>H		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	Homo sapiens mediator complex subunit 13 (MED13), mRNA.	1587					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	RNA polymerase II transcription cofactor activity|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TCTCCAGAAATCCCAGCTGTCTGTAGAGCTGATGTCTGTTGCCCTCCTAG	0.426												
ZNF44	51710	broad.mit.edu	37	19	12384018	12384024	+	Frame_Shift_Del	DEL	GAACCAG	GAACCAG	-			TCGA-D7-A4YT-01A-11D-A25D-08	TCGA-D7-A4YT-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f16cadc2-52ef-49b2-8cec-8929f4719d95	1cfe678d-c4cf-457a-8958-7c915f02eef7	g.chr19:12384017_12384023TGAACCAG>T	uc010xmj.2	-	4	1396_1402	c.1191_1197CTGGTTCA>A	c.(1189-1197)cctggttcafs	p.P397fs	ZNF44_uc002mtl.3_Intron|ZNF44_uc010xmi.2_Non-coding_Transcript|ZNF44_uc002mtn.4_Non-coding_Transcript|ZNF44_uc010dys.3_Frame_Shift_Del_p.P349fs	NM_001164276	NP_001157748	P15621	ZNF44_HUMAN	Homo sapiens zinc finger protein 44 (ZNF44), transcript variant 1, mRNA.	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		GAATTCGTGCTGAACCAGGAAAATCAA	0.401