Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
PRDM16	63976	broad.mit.edu	37	1	3319509	3319509	+	Silent	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr1:3319509C>T	uc001akf.2	+	6	911	c.831C>T	c.(829-831)AGC>AGT	p.S277S	PRDM16_uc001akc.2_Silent_p.S277S|PRDM16_uc001akd.2_Silent_p.S277S|PRDM16_uc001ake.2_Silent_p.S277S|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	277					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GCGGTGGCAGCGGCCAAGCCC	0.567			T	EVI1	MDS|AML							
ARID1A	8289	broad.mit.edu	37	1	27023420	27023420	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr1:27023420C>T	uc001bmv.1	+	1	899	c.526C>T	c.(526-528)CAA>TAA	p.Q176*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q176*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q176*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	176					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ACATGGCGGACAACAAAGCCC	0.731			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC							
SFPQ	6421	broad.mit.edu	37	1	35657111	35657111	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr1:35657111G>C	uc001bys.2	-	2	941	c.848C>G	c.(847-849)TCT>TGT	p.S283C	SFPQ_uc001byr.2_5'Flank	NM_005066	NP_005057	P23246	SFPQ_HUMAN	splicing factor proline/glutamine rich	283					alternative nuclear mRNA splicing, via spliceosome|DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|nucleotide binding|protein binding|protein binding|RNA binding		SFPQ/TFE3(6)	kidney(4)|soft_tissue(2)|ovary(1)|skin(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				CCTCAAGAGAGACAAATTGGC	0.408			T	TFE3	papillary renal cell							
ZYG11B	79699	broad.mit.edu	37	1	53261986	53261986	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr1:53261986A>G	uc001cuj.2	+	7	1552	c.1357A>G	c.(1357-1359)ATG>GTG	p.M453V	ZYG11B_uc009vzg.2_RNA|ZYG11B_uc010onj.1_Missense_Mutation_p.M444V|ZYG11B_uc009vzh.2_5'Flank	NM_024646	NP_078922	Q9C0D3	ZY11B_HUMAN	zyg-11 homolog B	453							protein binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CAAGCTTGTCATGCAGTGGCT	0.448												
SPAG17	200162	broad.mit.edu	37	1	118581983	118581983	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr1:118581983T>C	uc001ehk.2	-	23	3319	c.3251A>G	c.(3250-3252)AAG>AGG	p.K1084R		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1084						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTTCTCTTCCTTTTTCACAAT	0.378												
TCHH	7062	broad.mit.edu	37	1	152084596	152084596	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr1:152084596C>T	uc001ezp.2	-	2	1097	c.1097G>A	c.(1096-1098)CGC>CAC	p.R366H	TCHH_uc009wne.1_Missense_Mutation_p.R366H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	366	5 X 13 AA tandem repeats of R-R-E-Q-E-E- E-R-R-E-Q-Q-L.|1-5.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ctcctgctcgcgcctcagctg	0												
RNASEL	6041	broad.mit.edu	37	1	182555204	182555204	+	Silent	SNP	T	T	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr1:182555204T>G	uc001gpj.1	-	1	905	c.738A>C	c.(736-738)GCA>GCC	p.A246A	RNASEL_uc009wxz.1_Silent_p.A246A|RNASEL_uc001gpk.2_Silent_p.A246A|RNASEL_uc009wya.1_Silent_p.A246A	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	246	ANK 7.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						TCTTCTCCACTGCCAGGATCA	0.517									Hereditary_Prostate_Cancer			
FAM5C	339479	broad.mit.edu	37	1	190067820	190067820	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr1:190067820C>G	uc001gse.1	-	8	1861	c.1629G>C	c.(1627-1629)AAG>AAC	p.K543N	FAM5C_uc010pot.1_Missense_Mutation_p.K441N	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	543						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CCAGACTTGACTTGTACTTAT	0.448												
OBSCN	84033	broad.mit.edu	37	1	228469665	228469665	+	Silent	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr1:228469665G>A	uc009xez.1	+	31	8273	c.8229G>A	c.(8227-8229)AAG>AAA	p.K2743K	OBSCN_uc001hsn.2_Silent_p.K2743K|OBSCN_uc001hsp.1_Silent_p.K442K|OBSCN_uc001hsq.1_5'UTR	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2743	Ig-like 27.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGAGGCTGAAGACAATGGAGG	0.617												
CUBN	8029	broad.mit.edu	37	10	16996518	16996518	+	Silent	SNP	G	G	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr10:16996518G>T	uc001ioo.2	-	32	4777	c.4725C>A	c.(4723-4725)TCC>TCA	p.S1575S		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1575	CUB 10.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGGCAAGGCGGGACATTGTGG	0.522												
RET	5979	broad.mit.edu	37	10	43600608	43600608	+	Silent	SNP	C	C	T	rs41306550		TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr10:43600608C>T	uc001jal.2	+	4	1024	c.834C>T	c.(832-834)ACC>ACT	p.T278T	RET_uc001jak.1_Silent_p.T278T|RET_uc010qez.1_Silent_p.T24T	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	278	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity	p.T278N(2)		thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	GCGTCGACACCGCCAGCGCCG	0.687		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma			
GRID1	2894	broad.mit.edu	37	10	87484322	87484322	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr10:87484322C>T	uc001kdl.1	-	11	1746	c.1645G>A	c.(1645-1647)GAG>AAG	p.E549K	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.E120K	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	549	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	ATTTTCTCCTCGGGCTTCTTA	0.512										Multiple Myeloma(13;0.14)		
ENTPD7	57089	broad.mit.edu	37	10	101458523	101458523	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr10:101458523T>G	uc001kqa.3	+	10	1421	c.1243T>G	c.(1243-1245)TTC>GTC	p.F415V	ENTPD7_uc009xwl.2_Missense_Mutation_p.F417V	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	415	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		CAACAGCGAGTTCTACGGCTT	0.507												
DPYSL4	10570	broad.mit.edu	37	10	134016171	134016171	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr10:134016171G>A	uc009ybb.2	+	12	1457	c.1303G>A	c.(1303-1305)GAG>AAG	p.E435K		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	435					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		CAACATCTTCGAGGGAGTGGA	0.667												
OR51F1	256892	broad.mit.edu	37	11	4790243	4790243	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr11:4790243C>T	uc010qyl.1	-	1	905	c.905G>A	c.(904-906)CGC>CAC	p.R302H		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	302						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		CATAGCCTTGCGGATTTGTTT	0.433												
OR52H1	390067	broad.mit.edu	37	11	5565982	5565982	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr11:5565982T>A	uc010qzh.1	-	1	772	c.772A>T	c.(772-774)ATG>TTG	p.M258L	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	258	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTATAAAACATGAGGATGACA	0.493												
MRPL17	63875	broad.mit.edu	37	11	6703464	6703464	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr11:6703464C>G	uc001men.2	-	3	518	c.413G>C	c.(412-414)AGA>ACA	p.R138T		NM_022061	NP_071344	Q9NRX2	RM17_HUMAN	mitochondrial ribosomal protein L17 precursor	138					translation	ribosome	protein domain specific binding|structural constituent of ribosome				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GTGGCTGTCTCTGCGAGGCAG	0.557												
E2F8	79733	broad.mit.edu	37	11	19256429	19256429	+	Nonsense_Mutation	SNP	T	T	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr11:19256429T>A	uc001mpm.2	-	5	1150	c.628A>T	c.(628-630)AAA>TAA	p.K210*	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Nonsense_Mutation_p.K210*	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	210					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TCTTTCTTTTTGATCATCATA	0.428												
RAPSN	5913	broad.mit.edu	37	11	47463391	47463391	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr11:47463391C>T	uc001nfi.1	-	4	987	c.773G>A	c.(772-774)AGC>AAC	p.S258N	RAPSN_uc001nfj.1_Missense_Mutation_p.S258N|RAPSN_uc009yls.1_Missense_Mutation_p.S258N	NM_005055	NP_005046	Q13702	RAPSN_HUMAN	43 kD receptor-associated protein of the synapse	258	TPR 6.				synaptic transmission, cholinergic	cell junction|cytoskeleton|postsynaptic membrane	acetylcholine receptor binding|zinc ion binding			ovary(1)	1						GTCCCCACGGCTCCGGTGGAT	0.682												
OSBP	5007	broad.mit.edu	37	11	59344413	59344413	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr11:59344413G>A	uc001noc.1	-	13	2626	c.2146C>T	c.(2146-2148)CGG>TGG	p.R716W	OSBP_uc009ymr.1_RNA	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	716					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GGTCGTAACCGGCTGTCTGTG	0.483												
RPS3	6188	broad.mit.edu	37	11	75115769	75115769	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr11:75115769A>G	uc001owh.2	+	6	622	c.592A>G	c.(592-594)ATT>GTT	p.I198V	RPS3_uc001owi.2_Missense_Mutation_p.I198V|RPS3_uc001owk.1_Missense_Mutation_p.I72V	NM_001005	NP_000996	P23396	RS3_HUMAN	ribosomal protein S3	198					activation of caspase activity|endocrine pancreas development|induction of apoptosis|negative regulation of DNA repair|negative regulation of NF-kappaB transcription factor activity|response to DNA damage stimulus|translational elongation|translational initiation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleus|ruffle membrane	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|iron-sulfur cluster binding|mRNA binding|NF-kappaB binding|protein kinase binding|structural constituent of ribosome				0						AACTGGTAAGATTGGCCCTAA	0.562												
DSCAML1	57453	broad.mit.edu	37	11	117376176	117376176	+	Silent	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr11:117376176G>A	uc001prh.1	-	9	2237	c.2235C>T	c.(2233-2235)ATC>ATT	p.I745I		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	685	Extracellular (Potential).|Ig-like C2-type 7.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CACCACGCACGATGAGCTGGC	0.582												
WNK1	65125	broad.mit.edu	37	12	990059	990059	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr12:990059A>G	uc001qio.3	+	12	3512	c.3005A>G	c.(3004-3006)AAT>AGT	p.N1002S	WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1002					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GTGGAATCAAATCTTTTAGTT	0.517												
CLEC12A	160364	broad.mit.edu	37	12	10133333	10133333	+	Splice_Site	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr12:10133333G>A	uc001qwr.3	+	4	719	c.531_splice	c.e4+1	p.L177_splice	CLEC12A_uc001qwq.2_Splice_Site_p.L187_splice|CLEC12A_uc001qws.3_Splice_Site_p.L144_splice|CLEC12A_uc001qwt.2_Splice_Site_p.L106_splice	NM_138337	NP_612210	Q5QGZ9	CL12A_HUMAN	myeloid inhibitory C-type lectin-like receptor							integral to membrane|plasma membrane	receptor activity|sugar binding			skin(1)	1						AAATGCATTGGTAAAGCCCAG	0.433												
ALG10B	144245	broad.mit.edu	37	12	38714279	38714279	+	Missense_Mutation	SNP	A	A	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr12:38714279A>T	uc001rln.3	+	3	825	c.686A>T	c.(685-687)GAA>GTA	p.E229V	ALG10B_uc001rlo.3_Missense_Mutation_p.E199V|ALG10B_uc010skk.1_Missense_Mutation_p.E169V	NM_001013620	NP_001013642	Q5I7T1	AG10B_HUMAN	asparagine-linked glycosylation 10 homolog B	229	Cytoplasmic (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			ovary(2)|skin(1)	3	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				CCATTTGCAGAATTCAGAAAA	0.383												
SCN8A	6334	broad.mit.edu	37	12	52115568	52115568	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr12:52115568G>A	uc001ryw.2	+	12	2052	c.1874G>A	c.(1873-1875)CGC>CAC	p.R625H	SCN8A_uc010snl.1_Missense_Mutation_p.R490H|SCN8A_uc001ryx.1_Missense_Mutation_p.R490H|SCN8A_uc001ryz.1_Missense_Mutation_p.R490H|SCN8A_uc001ryy.2_Missense_Mutation_p.R490H	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	625					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CAGGGCAGCCGCTCCTCGCGC	0.637												
APPL2	55198	broad.mit.edu	37	12	105597491	105597491	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr12:105597491T>C	uc001tlf.1	-	9	912	c.694A>G	c.(694-696)ATG>GTG	p.M232V	APPL2_uc010swt.1_Missense_Mutation_p.M189V|APPL2_uc001tlg.1_5'UTR|APPL2_uc010swu.1_Missense_Mutation_p.M238V|APPL2_uc009zuq.2_Missense_Mutation_p.M189V	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	232	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						CTTTGAACCATGTCTGCAACG	0.443												
FRY	10129	broad.mit.edu	37	13	32811574	32811574	+	Nonsense_Mutation	SNP	G	G	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr13:32811574G>T	uc001utx.2	+	44	6365	c.5869G>T	c.(5869-5871)GGA>TGA	p.G1957*	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1957					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AAAGAGCACAGGACAACTAAA	0.473												
KBTBD6	89890	broad.mit.edu	37	13	41706551	41706551	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr13:41706551A>G	uc001uxu.1	-	1	386	c.97T>C	c.(97-99)TTT>CTT	p.F33L	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.F33L|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	33							protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		CCCGTGAAAAAGGCCGAAACT	0.607												
RASA3	22821	broad.mit.edu	37	13	114795308	114795308	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr13:114795308A>G	uc001vui.2	-	5	559	c.428T>C	c.(427-429)GTC>GCC	p.V143A	RASA3_uc010tkk.1_Missense_Mutation_p.V111A|RASA3_uc001vuj.2_5'UTR|RASA3_uc010tkl.1_RNA|RASA3_uc010aha.1_RNA	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	143	C2 2.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			CTTGTGGCAGACGACCCCAGT	0.622												
SYNE2	23224	broad.mit.edu	37	14	64484436	64484436	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr14:64484436T>A	uc001xgm.2	+	34	5241	c.5011T>A	c.(5011-5013)TTA>ATA	p.L1671I	SYNE2_uc001xgl.2_Missense_Mutation_p.L1671I	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1671	Cytoplasmic (Potential).|Potential.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAAAATGGAATTACATCAATT	0.323												
MTA1	9112	broad.mit.edu	37	14	105931113	105931113	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr14:105931113C>T	uc001yqx.2	+	15	1634	c.1447C>T	c.(1447-1449)CGG>TGG	p.R483W	MTA1_uc001yqy.2_RNA|MTA1_uc001yrb.2_Missense_Mutation_p.R244W	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	483					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		GCGGATCGCCCGGCGCCTGTG	0.677												
C15orf2	23742	broad.mit.edu	37	15	24922918	24922918	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr15:24922918T>C	uc001ywo.2	+	1	2378	c.1904T>C	c.(1903-1905)TTT>TCT	p.F635S		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	635					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		ACCCCAAGTTTTAACCAACTC	0.493												
LCMT2	9836	broad.mit.edu	37	15	43621365	43621365	+	Silent	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr15:43621365A>G	uc001zrg.2	-	1	1527	c.1323T>C	c.(1321-1323)AGT>AGC	p.S441S	LCMT2_uc010udn.1_Silent_p.S20S|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	441					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	CCAAGGCTGGACTTACTGGGG	0.493												
ARID3B	10620	broad.mit.edu	37	15	74882324	74882324	+	Silent	SNP	C	C	G	rs144245237	byFrequency	TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr15:74882324C>G	uc002aye.2	+	5	1062	c.861C>G	c.(859-861)GCC>GCG	p.A287A	ARID3B_uc002ayd.2_Silent_p.A287A|ARID3B_uc010bjs.1_5'Flank	NM_006465	NP_006456	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B	287	ARID.|Interaction with RB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						TCACCAGCGCCGCCTTCACCC	0.572												
CSPG4	1464	broad.mit.edu	37	15	75980584	75980584	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr15:75980584C>T	uc002baw.2	-	3	2915	c.2822G>A	c.(2821-2823)CGC>CAC	p.R941H		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	941	Interaction with COL5A1 (By similarity).|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|CSPG 5.|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						CCTCCCATGGCGGGGCCGCTC	0.582												
CHD2	1106	broad.mit.edu	37	15	93524598	93524598	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr15:93524598A>G	uc002bsp.2	+	24	3552	c.2977A>G	c.(2977-2979)ATG>GTG	p.M993V	CHD2_uc002bso.1_Missense_Mutation_p.M993V	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	993	Glu-rich.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CTTTTAGGAAATGGATATAGA	0.358												
ABCC12	94160	broad.mit.edu	37	16	48167651	48167651	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr16:48167651C>T	uc002efc.1	-	7	1421	c.1075G>A	c.(1075-1077)GTG>ATG	p.V359M	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Missense_Mutation_p.V359M|ABCC12_uc010vgj.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	359	ABC transmembrane type-1 1.|Helical; (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				AATGTCAGCACGATGGCTATG	0.527												
ABCC11	85320	broad.mit.edu	37	16	48226539	48226539	+	Silent	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr16:48226539G>A	uc002eff.1	-	19	2948	c.2598C>T	c.(2596-2598)TAC>TAT	p.Y866Y	ABCC11_uc002efg.1_Silent_p.Y866Y|ABCC11_uc002efh.1_Silent_p.Y866Y|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	866	Helical; (Potential).|ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CGTTGAGCCCGTACACCAGCT	0.552									Cerumen_Type			
SLC12A4	6560	broad.mit.edu	37	16	67980104	67980104	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr16:67980104C>A	uc002euz.2	-	19	2718	c.2577G>T	c.(2575-2577)ATG>ATT	p.M859I	LCAT_uc002euy.1_5'Flank|SLC12A4_uc010ceu.2_Missense_Mutation_p.M853I|SLC12A4_uc010vkh.1_Missense_Mutation_p.M828I|SLC12A4_uc010vki.1_Missense_Mutation_p.M859I|SLC12A4_uc010vkj.1_Missense_Mutation_p.M861I|SLC12A4_uc002eva.2_Missense_Mutation_p.M859I|SLC12A4_uc010cev.1_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	859	Helical; (Potential).				cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	AGGGCAGAAGCATGAGCATGC	0.612												
CIRH1A	84916	broad.mit.edu	37	16	69201031	69201031	+	Silent	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr16:69201031A>G	uc002ews.3	+	16	1983	c.1887A>G	c.(1885-1887)GAA>GAG	p.E629E	CIRH1A_uc002ewr.2_3'UTR|CIRH1A_uc002ewt.3_Silent_p.E546E|CIRH1A_uc010cfi.2_Silent_p.E431E	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	629						nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		CCACGAATGAATCAGATGTCA	0.363												
ASGR2	433	broad.mit.edu	37	17	7005041	7005041	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr17:7005041C>A	uc002gep.3	-	9	1054	c.789G>T	c.(787-789)CAG>CAT	p.Q263H	ASGR2_uc010vtk.1_Missense_Mutation_p.Q100H|ASGR2_uc002gem.1_Missense_Mutation_p.Q202H|ASGR2_uc002gen.1_Missense_Mutation_p.Q244H|ASGR2_uc002geo.1_Missense_Mutation_p.Q258H|ASGR2_uc002ger.3_Missense_Mutation_p.Q263H|ASGR2_uc002geq.3_Missense_Mutation_p.Q239H	NM_001181	NP_001172	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2 isoform a	263	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			ovary(1)	1					Antihemophilic Factor(DB00025)	AATTATCTGGCTGAGTGACAG	0.552												
ALDH3A2	224	broad.mit.edu	37	17	19559856	19559856	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr17:19559856G>A	uc002gwb.1	+	4	870	c.649G>A	c.(649-651)GAT>AAT	p.D217N	ALDH3A2_uc002gwa.1_Missense_Mutation_p.D217N|ALDH3A2_uc010cqr.1_Missense_Mutation_p.D24N|ALDH3A2_uc002gwc.1_Missense_Mutation_p.D217N|ALDH3A2_uc002gwd.1_Missense_Mutation_p.D24N	NM_000382	NP_000373	P51648	AL3A2_HUMAN	aldehyde dehydrogenase 3A2 isoform 2	217	Cytoplasmic.				cellular aldehyde metabolic process|central nervous system development|epidermis development|lipid metabolic process|peripheral nervous system development	endoplasmic reticulum membrane|integral to membrane	3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(2)	2	all_cancers(12;1.39e-05)|all_epithelial(12;0.00158)|Breast(13;0.245)				NADH(DB00157)	ATGTTATATTGATAAAGATTG	0.458												
KCNJ12	3768	broad.mit.edu	37	17	21318895	21318895	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr17:21318895C>T	uc002gyv.1	+	3	946	c.241C>T	c.(241-243)CGG>TGG	p.R81W		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	81	Helical; Name=M1; (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CATCCGCTGGCGGTACATGCT	0.577										Prostate(3;0.18)		
WFIKKN2	124857	broad.mit.edu	37	17	48917272	48917272	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr17:48917272C>T	uc002isv.3	+	2	1317	c.623C>T	c.(622-624)GCG>GTG	p.A208V	WFIKKN2_uc010dbu.2_Missense_Mutation_p.A115V	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	208						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CTGGACATGGCGGCCCCTGCG	0.652												
SFRS1	6426	broad.mit.edu	37	17	56084463	56084463	+	Silent	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr17:56084463C>T	uc002ivi.2	-	1	245	c.36G>A	c.(34-36)GGG>GGA	p.G12G	SFRS1_uc002ivj.2_Silent_p.G12G	NM_006924	NP_008855	Q07955	SRSF1_HUMAN	splicing factor, arginine/serine-rich 1 isoform	12					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA 5'-splice site recognition|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytoplasm|nuclear speck	nucleotide binding|RNA binding				0		Colorectal(1115;0.0691)		LUAD - Lung adenocarcinoma(1115;0.247)		AATCGTTGTTCCCTGCGGGGC	0.587												
OR4D2	124538	broad.mit.edu	37	17	56247498	56247498	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr17:56247498C>T	uc010wnp.1	+	1	482	c.482C>T	c.(481-483)GCT>GTT	p.A161V		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GTCCAGCTGGCTCTGATGCTC	0.567												
EPX	8288	broad.mit.edu	37	17	56271430	56271430	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr17:56271430C>T	uc002ivq.2	+	5	657	c.571C>T	c.(571-573)CGC>TGC	p.R191C		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	191					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						CAGCAGGAGGCGCAATGGCTT	0.517												
SCAMP4	113178	broad.mit.edu	37	19	1918891	1918891	+	Silent	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr19:1918891C>T	uc002luj.2	+	5	404	c.297C>T	c.(295-297)GCC>GCT	p.A99A	SCAMP4_uc002lui.1_Silent_p.A99A|SCAMP4_uc002luk.2_Intron|SCAMP4_uc010dss.2_Silent_p.A55A	NM_079834	NP_524558	Q969E2	SCAM4_HUMAN	secretory carrier membrane protein 4	99					protein transport	integral to membrane					0		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCCCAGAGCCGACAGCTCCT	0.587												
PLIN4	729359	broad.mit.edu	37	19	4504699	4504699	+	Silent	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr19:4504699G>A	uc002mar.1	-	6	3846	c.3846C>T	c.(3844-3846)GCC>GCT	p.A1282A	PLIN4_uc010dub.1_Silent_p.A306A	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	1282						lipid particle|plasma membrane					0						GCTGGAGCTCGGCGGGCAGGC	0.701												
MUC16	94025	broad.mit.edu	37	19	9059719	9059719	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr19:9059719C>A	uc002mkp.2	-	3	27931	c.27727G>T	c.(27727-27729)GCT>TCT	p.A9243S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9245	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACTGAGTCAGCTAGGACAGAG	0.463												
ZNF426	79088	broad.mit.edu	37	19	9639881	9639881	+	Silent	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr19:9639881G>A	uc002mlq.2	-	8	1104	c.840C>T	c.(838-840)TAC>TAT	p.Y280Y	ZNF426_uc010dws.2_Silent_p.Y242Y	NM_024106	NP_077011	Q9BUY5	ZN426_HUMAN	zinc finger protein 426	280	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CCTTACATTTGTAGGGCTTTT	0.418												
PPAN-P2RY11	692312	broad.mit.edu	37	19	10225259	10225259	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr19:10225259G>A	uc002mna.2	+	13	2230	c.2230G>A	c.(2230-2232)GCA>ACA	p.A744T	PPAN-P2RY11_uc010xla.1_3'UTR|P2RY11_uc002mnc.2_Missense_Mutation_p.A324T	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	Error:Variant_position_missing_in_Q9NQ55_after_alignment					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			CTACATGGCCGCAGTGCCCAG	0.677												
CYP4F3	4051	broad.mit.edu	37	19	15763705	15763705	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr19:15763705G>A	uc002nbj.2	+	9	1108	c.1058G>A	c.(1057-1059)CGC>CAC	p.R353H	CYP4F3_uc010xok.1_Missense_Mutation_p.R353H|CYP4F3_uc010xol.1_Missense_Mutation_p.R353H|CYP4F3_uc010xom.1_Missense_Mutation_p.R204H|CYP4F3_uc002nbk.2_Missense_Mutation_p.R353H|CYP4F3_uc010xon.1_Missense_Mutation_p.R63H	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	353					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						TACCAGGAGCGCTGTCGGCAG	0.592												
PGPEP1	54858	broad.mit.edu	37	19	18468415	18468415	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr19:18468415G>A	uc002nis.1	+	4	511	c.427G>A	c.(427-429)GAT>AAT	p.D143N	PGPEP1_uc002nir.1_RNA|PGPEP1_uc002nit.1_Missense_Mutation_p.D66N|PGPEP1_uc010xqg.1_Missense_Mutation_p.D66N	NM_017712	NP_060182	Q9NXJ5	PGPI_HUMAN	pyroglutamyl-peptidase I	143							cysteine-type peptidase activity				0						CATCTCGCAGGATGCCGGCAG	0.602												
FCGBP	8857	broad.mit.edu	37	19	40433845	40433845	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr19:40433845C>T	uc002omp.3	-	2	432	c.424G>A	c.(424-426)GAG>AAG	p.E142K		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	142	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACAAAATACTCGGTGCCTAGG	0.602												
DPRX	503834	broad.mit.edu	37	19	54137863	54137863	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr19:54137863A>G	uc002qcf.1	+	2	158	c.107A>G	c.(106-108)AAT>AGT	p.N36S		NM_001012728	NP_001012746	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	36	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		ATCTTGTTCAATGAGAACCCA	0.443												
ZNF835	90485	broad.mit.edu	37	19	57175194	57175194	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr19:57175194C>A	uc010ygo.1	-	2	1439	c.1439G>T	c.(1438-1440)CGC>CTC	p.R480L	ZNF835_uc010ygn.1_Missense_Mutation_p.R458L	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CAGGTAGGAGCGGTTGCTGAA	0.667												
ROCK2	9475	broad.mit.edu	37	2	11427816	11427816	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr2:11427816C>T	uc002rbd.1	-	2	637	c.188G>A	c.(187-189)AGG>AAG	p.R63K		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	63					axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		CTTGTTTTTCCTCAAAGCAGG	0.279												
ZNF514	84874	broad.mit.edu	37	2	95815288	95815288	+	Silent	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr2:95815288C>T	uc002sue.1	-	5	1316	c.942G>A	c.(940-942)AAG>AAA	p.K314K	ZNF514_uc002sud.1_Silent_p.K387K	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTCATAGGGCTTTTCTCCAG	0.428												
FBLN7	129804	broad.mit.edu	37	2	112940381	112940381	+	Silent	SNP	T	T	C			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr2:112940381T>C	uc002tho.1	+	6	955	c.684T>C	c.(682-684)TGT>TGC	p.C228C	FBLN7_uc002thn.2_Silent_p.C228C|FBLN7_uc010fki.1_Silent_p.C182C|FBLN7_uc010fkj.1_Intron	NM_153214	NP_694946	Q53RD9	FBLN7_HUMAN	fibulin 7 isoform 1	228	EGF-like 2; calcium-binding (Potential).				cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			ovary(1)|central_nervous_system(1)	2						TGAACGAGTGTGAGCTCTACG	0.592												
NR4A2	4929	broad.mit.edu	37	2	157184976	157184976	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr2:157184976G>A	uc002tyz.3	-	4	1356	c.934C>T	c.(934-936)CGG>TGG	p.R312W	NR4A2_uc002tyx.3_Missense_Mutation_p.R249W|NR4A2_uc010zcf.1_Missense_Mutation_p.R312W|NR4A2_uc010zcg.1_5'Flank	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	312	NR C4-type.|Nuclear receptor.				cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						CAGCGATTCCGGCGACGCTTG	0.493												
TTN	7273	broad.mit.edu	37	2	179438575	179438575	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr2:179438575C>A	uc010zfg.1	-	275	64804	c.64580G>T	c.(64579-64581)AGG>ATG	p.R21527M	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R15222M|TTN_uc010zfi.1_Missense_Mutation_p.R15155M|TTN_uc010zfj.1_Missense_Mutation_p.R15030M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22454							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCACTATCCCTTCTTGTTGA	0.413												
FAM171B	165215	broad.mit.edu	37	2	187611822	187611822	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr2:187611822C>T	uc002ups.2	+	4	681	c.569C>T	c.(568-570)GCC>GTC	p.A190V	FAM171B_uc002upr.1_Missense_Mutation_p.A190V	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	190	Extracellular (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						TTTCCAGATGCCAAGTCTCAA	0.353												
STAT1	6772	broad.mit.edu	37	2	191843630	191843630	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr2:191843630C>T	uc002usj.2	-	21	2213	c.1825G>A	c.(1825-1827)GAA>AAA	p.E609K	STAT1_uc010fse.1_Missense_Mutation_p.E609K|STAT1_uc002usk.2_Missense_Mutation_p.E609K|STAT1_uc002usl.2_Missense_Mutation_p.E611K	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	609	SH2.				activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	ATGGCCCCTTCCCGGGAGCTC	0.602												
DNAH7	56171	broad.mit.edu	37	2	196825327	196825327	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr2:196825327G>A	uc002utj.3	-	18	2649	c.2548C>T	c.(2548-2550)CGC>TGC	p.R850C		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	850	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TGCCTGGGGCGCAAACCAGGA	0.453												
ALS2CR8	79800	broad.mit.edu	37	2	203846292	203846292	+	Nonsense_Mutation	SNP	G	G	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr2:203846292G>T	uc002uzo.2	+	14	1853	c.1573G>T	c.(1573-1575)GAA>TAA	p.E525*	ALS2CR8_uc010zia.1_Nonsense_Mutation_p.E449*|ALS2CR8_uc010zib.1_Nonsense_Mutation_p.E449*|ALS2CR8_uc010zic.1_Nonsense_Mutation_p.E437*|ALS2CR8_uc002uzp.2_Nonsense_Mutation_p.E525*	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	525										large_intestine(1)|ovary(1)	2						TTCACCAGGAGAATCAATTAC	0.348												
SLC11A1	6556	broad.mit.edu	37	2	219251382	219251382	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr2:219251382A>G	uc002vhv.2	+	5	758	c.418A>G	c.(418-420)ACC>GCC	p.T140A	SLC11A1_uc010zkb.1_Nonstop_Mutation_p.*164W|SLC11A1_uc010fvp.1_Missense_Mutation_p.T140A|SLC11A1_uc010fvq.1_Missense_Mutation_p.T73A|SLC11A1_uc010zkc.1_Missense_Mutation_p.T73A|SLC11A1_uc002vhu.1_5'UTR|SLC11A1_uc002vhw.2_Missense_Mutation_p.T22A|SLC11A1_uc010fvr.2_5'UTR	NM_000578	NP_000569	P49279	NRAM1_HUMAN	natural resistance-associated macrophage protein	140	Cytoplasmic (Potential).				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			ovary(3)|central_nervous_system(1)	4		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTCTGGCTGACCATCGAGCT	0.567												
U2AF1	7307	broad.mit.edu	37	21	44514611	44514611	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr21:44514611C>T	uc002zda.1	-	7	629	c.545G>A	c.(544-546)CGG>CAG	p.R182Q	U2AF1_uc002zcy.1_Missense_Mutation_p.R109Q|U2AF1_uc002zcz.1_Missense_Mutation_p.R109Q|U2AF1_uc002zdb.1_Missense_Mutation_p.R182Q|U2AF1_uc010gpi.1_Missense_Mutation_p.R182Q	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	182	Arg/Gly/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						CAGCTCCCGCCGCAGCTCTCT	0.547												
LGALS2	3957	broad.mit.edu	37	22	37966653	37966653	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr22:37966653A>G	uc003ata.2	-	3	291	c.179T>C	c.(178-180)TTG>TCG	p.L60S		NM_006498	NP_006489	P05162	LEG2_HUMAN	lectin, galactoside-binding, soluble, 2	60	Galectin.									breast(1)|skin(1)	2	Melanoma(58;0.0574)					GCTGCCGTCCAATGAGTTGCA	0.547												
LAMB2	3913	broad.mit.edu	37	3	49160321	49160321	+	Silent	SNP	C	C	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr3:49160321C>A	uc003cwe.2	-	27	4688	c.4389G>T	c.(4387-4389)CTG>CTT	p.L1463L	USP19_uc003cvz.3_5'Flank|USP19_uc011bcg.1_5'Flank|USP19_uc003cwb.2_5'Flank|USP19_uc003cwd.1_5'Flank|USP19_uc011bch.1_5'Flank|USP19_uc011bci.1_5'Flank	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	1463	Domain I.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GTGCCCGCTGCAGCTCTGCCT	0.682												
ABHD10	55347	broad.mit.edu	37	3	111700750	111700750	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr3:111700750A>G	uc003dyk.3	+	2	343	c.262A>G	c.(262-264)ATG>GTG	p.M88V	ABHD10_uc011bhq.1_Intron	NM_018394	NP_060864	Q9NUJ1	ABHDA_HUMAN	abhydrolase domain containing 10 precursor	88						mitochondrion	serine-type peptidase activity				0						TCTTTCTTATATGAATGGTAC	0.403												
PIK3CA	5290	broad.mit.edu	37	3	178921553	178921553	+	Missense_Mutation	SNP	T	T	A	rs121913284		TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr3:178921553T>A	uc003fjk.2	+	5	1192	c.1035T>A	c.(1033-1035)AAT>AAA	p.N345K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	345					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.N345K(29)|p.N345I(2)|p.N345S(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCTACGTGAATGTAAATATTC	0.308		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)		
PIK3CA	5290	broad.mit.edu	37	3	178922324	178922324	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr3:178922324G>A	uc003fjk.2	+	6	1250	c.1093G>A	c.(1093-1095)GAA>AAA	p.E365K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	365	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E365K(2)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCATGGAGGAGAACCCTTATG	0.343		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)		
MFSD10	10227	broad.mit.edu	37	4	2934131	2934131	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr4:2934131C>T	uc003gfw.2	-	5	954	c.640G>A	c.(640-642)GAC>AAC	p.D214N	MFSD10_uc003gfv.2_5'Flank|MFSD10_uc003gfx.2_Missense_Mutation_p.D38N|MFSD10_uc003gfz.2_Missense_Mutation_p.D214N|MFSD10_uc003gfy.2_RNA|MFSD10_uc003gga.2_Missense_Mutation_p.D214N|MFSD10_uc003ggb.1_Missense_Mutation_p.D214N|MFSD10_uc003ggc.2_Missense_Mutation_p.D214N|C4orf10_uc003ggd.1_5'Flank|C4orf10_uc003gge.1_5'Flank	NM_001120	NP_001111	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing	214	Helical; (Potential).				apoptosis	integral to membrane	tetracycline transporter activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		AACAGCAGGTCGGAGGCTGCG	0.642												
HERC6	55008	broad.mit.edu	37	4	89317276	89317276	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr4:89317276C>T	uc011cdi.1	+	6	1052	c.869C>T	c.(868-870)TCG>TTG	p.S290L	HERC6_uc003hrp.1_RNA|HERC6_uc011cdj.1_Missense_Mutation_p.S290L|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_RNA	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	290	RCC1 5.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		GGCCTAGTTTCGCAGATAGAT	0.403												
SLC25A31	83447	broad.mit.edu	37	4	128651788	128651788	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr4:128651788G>A	uc003ifl.2	+	1	234	c.88G>A	c.(88-90)GCG>ACG	p.A30T		NM_031291	NP_112581	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier;	30	Solcar 1.|Helical; Name=1; (Potential).				transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity				0						CGGCGGAGTCGCGGCAGCTGT	0.622												
RAPGEF2	9693	broad.mit.edu	37	4	160259464	160259464	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr4:160259464G>A	uc003iqg.3	+	12	1964	c.1654G>A	c.(1654-1656)GAT>AAT	p.D552N		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	552					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TTTGTTCAGTGATATTGGGAT	0.353												
ANKRD32	84250	broad.mit.edu	37	5	94027907	94027907	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr5:94027907G>A	uc003kkr.3	+	20	2721	c.2641G>A	c.(2641-2643)GAT>AAT	p.D881N	ANKRD32_uc003kks.2_Missense_Mutation_p.D245N	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	881	ANK 3.									ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		TCCTTTGCATGATGCACTGTC	0.448												
SLCO6A1	133482	broad.mit.edu	37	5	101774450	101774450	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr5:101774450G>T	uc003knn.2	-	7	1319	c.1147C>A	c.(1147-1149)CCA>ACA	p.P383T	SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_Missense_Mutation_p.P383T|SLCO6A1_uc003knq.2_Missense_Mutation_p.P321T	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	383	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		ATGAGCACTGGATTCTTCATC	0.264												
DNAJC18	202052	broad.mit.edu	37	5	138758403	138758403	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr5:138758403T>C	uc003len.2	-	6	778	c.773A>G	c.(772-774)TAT>TGT	p.Y258C	DNAJC18_uc010jff.2_Missense_Mutation_p.Y196C	NM_152686	NP_689899	Q9H819	DJC18_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 18	258					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)|kidney(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TTACGATTTATAGAACAGACT	0.363												
PCDHA13	56136	broad.mit.edu	37	5	140263899	140263899	+	Silent	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr5:140263899G>A	uc003lif.2	+	1	2046	c.2046G>A	c.(2044-2046)GCG>GCA	p.A682A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.A682A|PCDHA13_uc003lid.2_Silent_p.A682A	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	682	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTCGAGGGCGTCGGCAGGCG	0.642												
PCDHGB6	56100	broad.mit.edu	37	5	140789875	140789875	+	Silent	SNP	C	C	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr5:140789875C>G	uc003lkj.1	+	1	2106	c.2106C>G	c.(2104-2106)CTC>CTG	p.L702L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Silent_p.L702L|PCDHGA10_uc011day.1_5'Flank|PCDHGA10_uc003lkl.1_5'Flank	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	702	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTCAGTGCTCTTCCTCCTCG	0.577												
NR3C1	2908	broad.mit.edu	37	5	142693630	142693630	+	Nonsense_Mutation	SNP	C	C	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr5:142693630C>A	uc003lmz.2	-	3	1780	c.1288G>T	c.(1288-1290)GGA>TGA	p.G430*	NR3C1_uc003lmy.2_Nonsense_Mutation_p.G430*|NR3C1_uc003lna.2_Nonsense_Mutation_p.G430*|NR3C1_uc003lnb.2_Nonsense_Mutation_p.G430*|NR3C1_uc011dbk.1_Nonsense_Mutation_p.G33*|NR3C1_uc003lnc.2_Nonsense_Mutation_p.G430*|NR3C1_uc003lnd.2_Nonsense_Mutation_p.G430*|NR3C1_uc003lne.2_Nonsense_Mutation_p.G430*|NR3C1_uc003lnf.2_Nonsense_Mutation_p.G430*	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	430	NR C4-type.|Nuclear receptor.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	TAATGACATCCTGAAGCTTCA	0.448												
FAM184A	79632	broad.mit.edu	37	6	119324198	119324198	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr6:119324198G>C	uc003pyj.2	-	9	2302	c.1954C>G	c.(1954-1956)CTT>GTT	p.L652V	FAM184A_uc003pyk.3_Missense_Mutation_p.L532V|FAM184A_uc003pyl.3_Missense_Mutation_p.L532V	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	652	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						TCTTCACGAAGTTTAGAACAC	0.353												
KIAA1244	57221	broad.mit.edu	37	6	138640958	138640958	+	Silent	SNP	C	C	T	rs145838885		TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr6:138640958C>T	uc003qhu.2	+	28	4593	c.4593C>T	c.(4591-4593)CAC>CAT	p.H1531H		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1531					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ATTTCAAGCACGCTATTGGTC	0.498												
MLLT4	4301	broad.mit.edu	37	6	168323587	168323587	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr6:168323587A>G	uc003qwd.2	+	21	3078	c.2936A>G	c.(2935-2937)TAT>TGT	p.Y979C	MLLT4_uc003qwb.1_Missense_Mutation_p.Y964C|MLLT4_uc003qwc.1_Missense_Mutation_p.Y980C|MLLT4_uc003qwg.1_Missense_Mutation_p.Y289C	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	980					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TGGACAATATATTTTGAAGGT	0.408			T	MLL	AL							
USP42	84132	broad.mit.edu	37	7	6150918	6150918	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr7:6150918C>T	uc011jwo.1	+	2	277	c.154C>T	c.(154-156)CTT>TTT	p.L52F	USP42_uc011jwn.1_5'UTR|USP42_uc010kth.1_Missense_Mutation_p.L52F|USP42_uc011jwp.1_Missense_Mutation_p.L52F|USP42_uc011jwq.1_5'UTR	NM_032172	NP_115548	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	52					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		AAATCACACACTTTCTTTAGG	0.463												
CTTNBP2	83992	broad.mit.edu	37	7	117365228	117365228	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr7:117365228G>A	uc003vjf.2	-	18	4231	c.4139C>T	c.(4138-4140)CCT>CTT	p.P1380L		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1380										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		CCCAAAGCCAGGTTGTCTTTT	0.498												
KCND2	3751	broad.mit.edu	37	7	120382625	120382625	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr7:120382625A>G	uc003vjj.1	+	4	2401	c.1436A>G	c.(1435-1437)CAC>CGC	p.H479R		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	479	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					ACCCAGCACCACCACCTGCTT	0.453												
CSMD1	64478	broad.mit.edu	37	8	3087702	3087702	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr8:3087702C>T	uc011kwk.1	-	27	4598	c.4208G>A	c.(4207-4209)CGC>CAC	p.R1403H	CSMD1_uc011kwj.1_Missense_Mutation_p.R795H|CSMD1_uc003wqe.2_Missense_Mutation_p.R559H	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1403	Extracellular (Potential).|Sushi 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTCTCCATAGCGGGTGCCATT	0.522												
PREX2	80243	broad.mit.edu	37	8	68965375	68965375	+	Silent	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr8:68965375G>A	uc003xxv.1	+	9	1014	c.987G>A	c.(985-987)AAG>AAA	p.K329K	PREX2_uc003xxu.1_Silent_p.K329K|PREX2_uc011lez.1_Silent_p.K264K	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	329	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						ATGGATGGAAGATACATAACA	0.323												
ZFHX4	79776	broad.mit.edu	37	8	77618345	77618345	+	Nonsense_Mutation	SNP	T	T	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr8:77618345T>A	uc003yav.2	+	2	2409	c.2022T>A	c.(2020-2022)TGT>TGA	p.C674*	ZFHX4_uc003yat.1_Nonsense_Mutation_p.C674*|ZFHX4_uc003yau.1_Nonsense_Mutation_p.C674*|ZFHX4_uc003yaw.1_Nonsense_Mutation_p.C674*	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	674						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTGGCTCTTGTGTTTATTGTA	0.498										HNSCC(33;0.089)		
ZFHX4	79776	broad.mit.edu	37	8	77762599	77762599	+	Splice_Site	SNP	G	G	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr8:77762599G>A	uc003yav.2	+	9	4216	c.3829_splice	c.e9+1	p.G1277_splice	ZFHX4_uc003yau.1_Splice_Site_p.G1322_splice|ZFHX4_uc003yaw.1_Splice_Site_p.G1277_splice	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAATATTCAGGTATGCCATCT	0.463										HNSCC(33;0.089)		
ESRP1	54845	broad.mit.edu	37	8	95658491	95658491	+	Silent	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr8:95658491C>T	uc003ygq.3	+	4	654	c.471C>T	c.(469-471)GAC>GAT	p.D157D	ESRP1_uc003ygr.3_Silent_p.D157D|ESRP1_uc003ygs.3_Silent_p.D157D|ESRP1_uc003ygt.3_Silent_p.D157D|ESRP1_uc003ygu.3_Silent_p.D157D|ESRP1_uc003ygv.2_Translation_Start_Site|ESRP1_uc003ygw.2_Translation_Start_Site	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	157					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						ACAAACTGGACGTTGCCACAA	0.333												
JAK2	3717	broad.mit.edu	37	9	5078361	5078361	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr9:5078361G>C	uc010mhm.2	+	15	2161	c.2048G>C	c.(2047-2049)AGA>ACA	p.R683T	JAK2_uc003ziw.2_Missense_Mutation_p.R683T	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	683	Protein kinase 1.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding	p.R683G(40)|p.R683S(12)|p.R683T(2)|p.R683K(1)|p.I682_D686>(1)	PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		CTGCTTATCAGAGAAGAAGAC	0.363		1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial			
NFX1	4799	broad.mit.edu	37	9	33307203	33307203	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr9:33307203A>C	uc003zsq.2	+	5	1343	c.1282A>C	c.(1282-1284)AAT>CAT	p.N428H	SUGT1P1_uc010mjq.1_Intron|NFX1_uc011lnw.1_Missense_Mutation_p.N428H|NFX1_uc003zso.2_Missense_Mutation_p.N428H|NFX1_uc003zsp.1_Missense_Mutation_p.N428H|NFX1_uc010mjr.1_Missense_Mutation_p.N428H|NFX1_uc003zsr.2_Missense_Mutation_p.N428H	NM_002504	NP_002495	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	428					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		CAAGGTAAAGAATCCTGAGTG	0.418												
KIAA1045	23349	broad.mit.edu	37	9	34971401	34971401	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr9:34971401C>T	uc003zvq.2	+	2	284	c.106C>T	c.(106-108)CGC>TGC	p.R36C	KIAA1045_uc003zvr.2_Missense_Mutation_p.R36C	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	36							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			TTCCATCCGACGCACAGGTGA	0.617												
C9orf172	389813	broad.mit.edu	37	9	139739581	139739581	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr9:139739581C>A	uc011meh.1	+	1	715	c.715C>A	c.(715-717)CCG>ACG	p.P239T	PHPT1_uc004cjp.2_5'Flank	NM_001080482	NP_001073951	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	239	Pro-rich.										0						GTCGCGCACCCCGACGCCCAG	0.766												
BCOR	54880	broad.mit.edu	37	X	39921997	39921997	+	Splice_Site	SNP	A	A	G			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chrX:39921997A>G	uc004den.3	-	9	4465	c.4173_splice	c.e9+1	p.K1391_splice	BCOR_uc004dep.3_Splice_Site_p.K1357_splice|BCOR_uc004deo.3_Splice_Site_p.K1339_splice|BCOR_uc010nhb.2_Intron|BCOR_uc004dem.3_Splice_Site_p.K1357_splice	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c						heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						GTCAAGAGGTACCTTGCCATC	0.577												
CCDC36	339834	broad.mit.edu	37	3	49249271	49249272	+	Splice_Site	INS	-	-	TAAGT			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr3:49249270_49249271G>GTAAGT	uc003cwk.2	+	4	443	c.56_splice	c.e4+1	p.G19_splice	CCDC36_uc003cwl.4_Splice_Site_p.G19_splice|CCDC36_uc011bck.1_Splice_Site_p.G19_splice|CCDC36_uc010hkt.2_Splice_Site	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	Homo sapiens coiled-coil domain containing 36 (CCDC36), transcript variant 1, mRNA.	19										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		CAGGCTCTGGGTAAGTTTTCTG	0.401												
VPS4A	27183	broad.mit.edu	37	16	69356604	69356607	+	Splice_Site	DEL	GTAA	GTAA	-			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr16:69356603_69356606GGTAA>G	uc002eww.3	+	10	1340	c.1212_splice	c.e10+1	p.M404_splice		NM_013245	NP_037377	Q9UN37	VPS4A_HUMAN	Homo sapiens vacuolar protein sorting 4 homolog A (S. cerevisiae) (VPS4A), mRNA.	404					cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(3)	7		Ovarian(137;0.101)				TGGTTTGCATGGTAAGTGACTTGA	0.544												
CCDC36	339834	broad.mit.edu	37	3	49249271	49249272	+	Splice_Site	INS	-	-	TAAGT			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr3:49249270_49249271G>GTAAGT	uc003cwk.2	+	4	443	c.56_splice	c.e4+1	p.G19_splice	CCDC36_uc003cwl.4_Splice_Site_p.G19_splice|CCDC36_uc011bck.1_Splice_Site_p.G19_splice|CCDC36_uc010hkt.2_Splice_Site	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	Homo sapiens coiled-coil domain containing 36 (CCDC36), transcript variant 1, mRNA.	19										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		CAGGCTCTGGGTAAGTTTTCTG	0.401												
PDE5A	8654	broad.mit.edu	37	4	120440291	120440292	+	Frame_Shift_Ins	INS	-	-	TG			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr4:120440290_120440291T>TTG	uc003idh.3	-	13	2064_2065	c.1909_1910A>CAA	c.(1909-1911)aagfs	p.K637fs	PDE5A_uc003idf.3_Frame_Shift_Ins_p.K595fs|PDE5A_uc003idg.3_Frame_Shift_Ins_p.K585fs|AF085995_uc003idi.4_Intron	NM_001083	NP_246273	O76074	PDE5A_HUMAN	Homo sapiens phosphodiesterase 5A, cGMP-specific (PDE5A), transcript variant 1, mRNA.	637	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding			breast(4)|endometrium(2)|kidney(3)|large_intestine(8)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	27					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	GTCAGTCAGCTTGTTCTGCATG	0.406												
ATHL1	80162	broad.mit.edu	37	11	293712	293713	+	Frame_Shift_Ins	INS	-	-	C			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr11:293711_293712G>GC	uc010qvu.2	+	9	1713_1714	c.1598_1599G>GC	c.(1597-1599)ggcfs	p.G533fs	ATHL1_uc001lor.4_Frame_Shift_Ins_p.G285fs|ATHL1_uc001lou.4_Frame_Shift_Ins_p.G108fs|ATHL1_uc001lov.4_5'Flank	NM_025092	NP_079368	Q32M88	ATHL1_HUMAN	Homo sapiens ATH1, acid trehalase-like 1 (yeast) (ATHL1), mRNA.	533					carbohydrate metabolic process		hydrolase activity, acting on glycosyl bonds			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|skin(3)	17		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.38e-28)|Epithelial(43;3.25e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		TCCCCCCAGGGCCCCGCCATGA	0.619												
PAMR1	25891	broad.mit.edu	37	11	35513670	35513671	+	Frame_Shift_Ins	INS	-	-	C			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr11:35513669_35513670A>AC	uc001mwf.3	-	2	345_346	c.302_303T>GT	c.(301-303)ggtfs	p.G101fs	PAMR1_uc001mwg.3_Frame_Shift_Ins_p.G101fs|PAMR1_uc010rew.2_Frame_Shift_Ins_p.G101fs|PAMR1_uc010rex.2_Frame_Shift_Ins_p.G61fs	NM_015430	NP_056245	Q6UXH9	PAMR1_HUMAN	Homo sapiens peptidase domain containing associated with muscle regeneration 1 (PAMR1), transcript variant 1, mRNA.	101					proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						CATCCAAGGTACCCCCCCATGA	0.520												
ZNF280D	54816	broad.mit.edu	37	15	56924285	56924286	+	Frame_Shift_Ins	INS	-	-	T			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr15:56924284_56924285A>AT	uc002adu.3	-	21	2568_2569	c.2351_2352T>AT	c.(2350-2352)aatfs	p.N784fs	BC037892_uc002ads.3_5'Flank|ZNF280D_uc002adv.3_Frame_Shift_Ins_p.N771fs|ZNF280D_uc010bfq.3_Frame_Shift_Ins_p.N784fs|ZNF280D_uc002adt.3_Frame_Shift_Ins_p.N25fs|ZNF280D_uc010bfp.3_Non-coding_Transcript	NM_017661	NP_001002843	Q6N043	Z280D_HUMAN	Homo sapiens zinc finger protein 280D (ZNF280D), transcript variant 1, mRNA.	784					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(4)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	30				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		CATTACATCCATTTTTTTCTTT	0.302												
KIAA0430	9665	broad.mit.edu	37	16	15733043	15733050	+	Frame_Shift_Del	DEL	TCCACGTG	TCCACGTG	-			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr16:15733042_15733049ATCCACGTG>A	uc002ddr.3	-	1	249_256	c.42_49CACGTGGAT>T	c.(40-51)acacgtggatggfs	p.T14fs	KIAA0430_uc002ddq.3_Frame_Shift_Del_p.T13fs|KIAA0430_uc010uzv.2_Frame_Shift_Del_p.T14fs|KIAA0430_uc010uzw.2_Frame_Shift_Del_p.T14fs|KIAA0430_uc010uzx.2_Frame_Shift_Del_p.T13fs	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	Homo sapiens KIAA0430 (KIAA0430), transcript variant 1, mRNA.	13						peroxisome	RNA binding|nucleotide binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TGTTGAAGCCATCCACGTGTTCTACTGC	0.442												
PLK1	5347	broad.mit.edu	37	16	23700944	23700944	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr16:23700943_23700943CA>C	uc002dlz.1	+	8	1607	c.1554_1554CA>C	c.(1552-1554)cgcfs	p.R518fs		NM_005030	NP_005021	P53350	PLK1_HUMAN	Homo sapiens polo-like kinase 1 (PLK1), mRNA.	518	POLO box 2.		R -> H (in dbSNP:rs56027600).		G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	ATP binding|anaphase-promoting complex binding|polo kinase kinase activity|protein kinase binding	p.T517T(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(48;0.0156)		TCCGCACCCGCAGCGCCATCA	0.637												
VPS4A	27183	broad.mit.edu	37	16	69356604	69356607	+	Splice_Site	DEL	GTAA	GTAA	-			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr16:69356603_69356606GGTAA>G	uc002eww.3	+	10	1340	c.1212_splice	c.e10+1	p.M404_splice		NM_013245	NP_037377	Q9UN37	VPS4A_HUMAN	Homo sapiens vacuolar protein sorting 4 homolog A (S. cerevisiae) (VPS4A), mRNA.	404					cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(3)	7		Ovarian(137;0.101)				TGGTTTGCATGGTAAGTGACTTGA	0.544												
NOB1	28987	broad.mit.edu	37	16	69782978	69782979	+	In_Frame_Ins	INS	-	-	TCCTCC			TCGA-HU-8608-01A-11D-2394-08	TCGA-HU-8608-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2ee5dde-4342-4e78-88c5-3c9a8e10cbf5	0af3c4b6-0d9f-4630-b919-94bf0ec56529	g.chr16:69782977_69782978T>TTCCTCC	uc002exs.3	-	5	585_586	c.569_570A>GGAGGAA	c.(568-570)gaa>gGGAGGAA	p.190_190E>GR		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	Homo sapiens NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) (NOB1), mRNA.	190	Poly-Glu.					nucleus	metal ion binding|protein binding			breast(2)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						ACCCGTTTTCTTCCTCCTCCTC	0.520