Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
ALDH4A1	8659	broad.mit.edu	37	1	19203948	19203948	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr1:19203948G>A	uc001bbb.2	-	10	1375	c.1099C>T	c.(1099-1101)CGG>TGG	p.R367W	ALDH4A1_uc010ocu.1_Missense_Mutation_p.R307W|ALDH4A1_uc001bbc.2_Missense_Mutation_p.R367W	NM_170726	NP_733844	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4A1 isoform a precursor	367					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	TCCAGCAGCCGCCCTTTGATC	0.687000												
MACF1	23499	broad.mit.edu	37	1	39919394	39919394	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr1:39919394G>T	uc010oiu.1	+	53	16218	c.16087G>T	c.(16087-16089)GTA>TTA	p.V5363L	MACF1_uc010ois.1_Missense_Mutation_p.V4861L	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CATGAAGAAAGTAGAAGAAAA	0.408000												
HIVEP3	59269	broad.mit.edu	37	1	42047371	42047371	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr1:42047371G>A	uc001cgz.3	-	4	4311	c.3098C>T	c.(3097-3099)GCG>GTG	p.A1033V	HIVEP3_uc001cha.3_Missense_Mutation_p.A1033V|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1033	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGCCACCCGCGCTGGTGGAGC	0.587000												
RBM15	64783	broad.mit.edu	37	1	110883915	110883915	+	Missense_Mutation	SNP	C	C	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr1:110883915C>G	uc001dzl.1	+	1	1971	c.1888C>G	c.(1888-1890)CGA>GGA	p.R630G	RBM15_uc001dzm.1_Missense_Mutation_p.R630G|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	630	Arg-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		CAGAGGTGATCGAGATCTGCC	0.602000			T	MKL1	acute megakaryocytic leukemia							
HIST2H3D	653604	broad.mit.edu	37	1	149785222	149785222	+	Missense_Mutation	SNP	C	C	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr1:149785222C>G	uc010pbl.1	-	1	15	c.15G>C	c.(13-15)AAG>AAC	p.K5N	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	5					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						GGGCAGTCTGCTTAGTACGGG	0.572000												
SELENBP1	8991	broad.mit.edu	37	1	151338282	151338282	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr1:151338282G>A	uc001exx.2	-	8	931	c.884C>T	c.(883-885)CCC>CTC	p.P295L	SELENBP1_uc010pcy.1_Missense_Mutation_p.P337L|SELENBP1_uc001exy.2_Missense_Mutation_p.P192L|SELENBP1_uc001exz.2_Missense_Mutation_p.P192L|SELENBP1_uc010pcz.1_Missense_Mutation_p.P233L|SELENBP1_uc009wms.2_Missense_Mutation_p.P131L|SELENBP1_uc009wmt.2_Missense_Mutation_p.P192L|SELENBP1_uc001eya.2_Missense_Mutation_p.P231L|SELENBP1_uc009wmu.2_Missense_Mutation_p.P192L	NM_003944	NP_003935	Q13228	SBP1_HUMAN	selenium binding protein 1	295					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding				0	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CACTTTCTTGGGGGGCACCTG	0.547000												
CHRNB2	1141	broad.mit.edu	37	1	154542274	154542274	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr1:154542274C>T	uc001ffg.2	+	3	481	c.217C>T	c.(217-219)CGG>TGG	p.R73W		NM_000748	NP_000739	P17787	ACHB2_HUMAN	neuronal nicotinic acetylcholine receptor beta 2	73	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	GCAGCATGAGCGGGAGCAGAT	0.607000												
IGSF8	93185	broad.mit.edu	37	1	160062789	160062789	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr1:160062789G>A	uc001fva.2	-	4	1282	c.1237C>T	c.(1237-1239)CGA>TGA	p.R413*	IGSF8_uc001fuz.2_Nonsense_Mutation_p.R413*|IGSF8_uc009wtf.2_Nonsense_Mutation_p.R413*	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	413	Ig-like C2-type 3.|Extracellular (Potential).				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CCAGACCCTCGAACATAGGCT	0.652000												
PIK3C2B	5287	broad.mit.edu	37	1	204401491	204401491	+	Missense_Mutation	SNP	A	A	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr1:204401491A>G	uc001haw.2	-	28	4471	c.3992T>C	c.(3991-3993)CTC>CCC	p.L1331P	PIK3C2B_uc010pqv.1_Missense_Mutation_p.L1303P	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1331	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GAAAAAATTGAGCTTTGTGGC	0.502000												
OR1C1	26188	broad.mit.edu	37	1	247921378	247921378	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr1:247921378C>A	uc010pza.1	-	1	331	c.331G>T	c.(331-333)GAC>TAC	p.D111Y		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AGGAGGCTGTCCATATTCACA	0.478000												
TRDMT1	1787	broad.mit.edu	37	10	17199614	17199614	+	Missense_Mutation	SNP	A	A	C			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr10:17199614A>C	uc001iop.2	-	8	761	c.713T>G	c.(712-714)ATT>AGT	p.I238S	TRDMT1_uc001ioq.2_Missense_Mutation_p.I214S|TRDMT1_uc001ior.2_Missense_Mutation_p.I192S|TRDMT1_uc001ios.2_Missense_Mutation_p.I167S|TRDMT1_uc009xjt.2_Missense_Mutation_p.I157S|TRDMT1_uc010qcc.1_Missense_Mutation_p.I167S|TRDMT1_uc010qcd.1_Missense_Mutation_p.I115S	NM_004412	NP_004403	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1 isoform	238					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			ovary(1)	1						TTTCCTGTGAATTTCTTCTGC	0.353000												
HECTD2	143279	broad.mit.edu	37	10	93244365	93244365	+	Missense_Mutation	SNP	A	A	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr10:93244365A>G	uc001khl.2	+	9	1023	c.923A>G	c.(922-924)AAG>AGG	p.K308R	LOC100188947_uc010qnl.1_Intron|HECTD2_uc010qnm.1_Missense_Mutation_p.K312R|HECTD2_uc001khm.2_RNA|HECTD2_uc009xty.1_5'UTR|HECTD2_uc001khn.1_5'UTR	NM_182765	NP_877497	Q5U5R9	HECD2_HUMAN	HECT domain containing 2 isoform a	308					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1						CCTATAACAAAGTGTTCCTGG	0.363000												
CWF19L1	55280	broad.mit.edu	37	10	101997883	101997883	+	Nonsense_Mutation	SNP	C	C	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr10:101997883C>A	uc001kqq.1	-	11	1237	c.1150G>T	c.(1150-1152)GAG>TAG	p.E384*	CWF19L1_uc001kqs.1_Nonsense_Mutation_p.E136*|CWF19L1_uc001kqr.1_Nonsense_Mutation_p.E384*|CWF19L1_uc001kqt.1_Nonsense_Mutation_p.E88*|CWF19L1_uc010qpn.1_Nonsense_Mutation_p.E247*|SNORA12_uc001kqu.1_5'Flank	NM_018294	NP_060764	Q69YN2	C19L1_HUMAN	CWF19-like 1, cell cycle control	384							catalytic activity				0		Colorectal(252;0.117)		Epithelial(162;3.78e-10)|all cancers(201;3.1e-08)		TTCTCCACCTCTTCTACCACC	0.488000												
OR51G2	81282	broad.mit.edu	37	11	4936857	4936857	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr11:4936857C>T	uc001lzr.1	-	1	37	c.37G>A	c.(37-39)GTT>ATT	p.V13I		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTAGCAGAAACGCTGCTGCTG	0.557000												
OR52A5	390054	broad.mit.edu	37	11	5152993	5152993	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr11:5152993C>A	uc010qyx.1	-	1	880	c.880G>T	c.(880-882)GTC>TTC	p.V294F		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	294	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		ACTCCATAGACAATAGGGTTG	0.378000												
HBG2	3048	broad.mit.edu	37	11	5275585	5275585	+	Silent	SNP	G	G	C			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr11:5275585G>C	uc001mai.1	-	2	689	c.252C>G	c.(250-252)GGC>GGG	p.G84G	HBG2_uc001mak.1_RNA|HBG2_uc001maj.1_Silent_p.G84G	NM_000559	NP_000550	P69892	HBG2_HUMAN	A-gamma globin	84					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGCAAAGGTGCCCTTGAGAT	0.522000												
OR4A47	403253	broad.mit.edu	37	11	48510956	48510956	+	Silent	SNP	T	T	C			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr11:48510956T>C	uc010rhx.1	+	1	612	c.612T>C	c.(610-612)GCT>GCC	p.A204A		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GAGGACTGGCTTGCACTATTG	0.438000												
OR8I2	120586	broad.mit.edu	37	11	55861250	55861250	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr11:55861250C>T	uc010rix.1	+	1	467	c.467C>T	c.(466-468)TCG>TTG	p.S156L		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					TTCACAAGCTCGCTGATATCT	0.433000												
TECTA	7007	broad.mit.edu	37	11	120998499	120998499	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr11:120998499G>A	uc010rzo.1	+	8	1813	c.1813G>A	c.(1813-1815)GTG>ATG	p.V605M		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	605	TIL 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CCACTACTCCGTGTGCACAAG	0.637000												
IGSF9B	22997	broad.mit.edu	37	11	133794727	133794727	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr11:133794727C>T	uc001qgx.3	-	15	2338	c.2107G>A	c.(2107-2109)GTC>ATC	p.V703I	IGSF9B_uc001qgy.1_Missense_Mutation_p.V545I	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	703	Fibronectin type-III 2.|Extracellular (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GTGCTGGAGACGCCGGCGATG	0.562000												
CD163L1	283316	broad.mit.edu	37	12	7531888	7531888	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr12:7531888G>A	uc001qsy.2	-	9	2083	c.2057C>T	c.(2056-2058)TCG>TTG	p.S686L	CD163L1_uc010sge.1_Missense_Mutation_p.S696L	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	686	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						CTCCATATCCGATGCATCTGA	0.463000												
FAM90A1	55138	broad.mit.edu	37	12	8374923	8374923	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr12:8374923G>A	uc001qui.2	-	7	1449	c.890C>T	c.(889-891)CCG>CTG	p.P297L	FAM90A1_uc001quh.2_Missense_Mutation_p.P297L	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	297							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		AGCCTGAATCGGAGCCGGGGC	0.642000												
KRT6C	286887	broad.mit.edu	37	12	52865203	52865203	+	Splice_Site	SNP	A	A	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr12:52865203A>T	uc001sal.3	-	4	960	c.912_splice	c.e4+1	p.A304_splice		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C						cytoskeleton organization	keratin filament	structural molecule activity	p.?(1)		ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GGAGATGCTTACTGCATCATA	0.463000												
KRT4	3851	broad.mit.edu	37	12	53207428	53207428	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr12:53207428C>T	uc001saz.2	-	1	908	c.637G>A	c.(637-639)GAA>AAA	p.E213K		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	139						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						TTGATCTGTTCGCGCTCTTCC	0.567000												
NOC4L	79050	broad.mit.edu	37	12	132635872	132635872	+	Silent	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr12:132635872C>T	uc001ujz.1	+	11	1073	c.1032C>T	c.(1030-1032)CGC>CGT	p.R344R		NM_024078	NP_076983	Q9BVI4	NOC4L_HUMAN	nucleolar complex associated 4 homolog	344					rRNA processing	integral to membrane|nuclear membrane|nucleolus	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.2e-08)|Epithelial(86;3.34e-07)|all cancers(50;1.97e-05)		TCAAGTACCGCGCCCGCTTCT	0.657000												
GOLGA3	2802	broad.mit.edu	37	12	133381458	133381458	+	Missense_Mutation	SNP	C	C	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr12:133381458C>G	uc001ukz.1	-	7	2000	c.1441G>C	c.(1441-1443)GAG>CAG	p.E481Q	GOLGA3_uc001ula.1_Missense_Mutation_p.E481Q|GOLGA3_uc001ulb.2_Missense_Mutation_p.E481Q	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	481	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		ATGGCTCGCTCCAGGTCCCAG	0.622000												
PABPC3	5042	broad.mit.edu	37	13	25670716	25670716	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr13:25670716C>T	uc001upy.2	+	1	441	c.380C>T	c.(379-381)TCG>TTG	p.S127L		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	127	RRM 2.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AACATCCTTTCGTGTAACGTG	0.368000												
FAM123A	219287	broad.mit.edu	37	13	25745314	25745314	+	Silent	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr13:25745314G>A	uc001uqb.2	-	1	544	c.444C>T	c.(442-444)GGC>GGT	p.G148G	FAM123A_uc001uqa.2_Silent_p.G148G|FAM123A_uc001uqc.2_Silent_p.G148G	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	148	Gly-rich.									ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GGGAGCCCCCGCCGGGCCCTG	0.567000												
EPSTI1	94240	broad.mit.edu	37	13	43543271	43543271	+	Missense_Mutation	SNP	T	T	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr13:43543271T>A	uc001uyw.1	-	3	366	c.290A>T	c.(289-291)CAG>CTG	p.Q97L	EPSTI1_uc001uyx.1_Missense_Mutation_p.Q97L	NM_001002264	NP_001002264	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 isoform 1	97	Potential.									ovary(1)	1		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		AGCTCTGTTCTGCTCCTTCCA	0.532000												
TNFSF13B	10673	broad.mit.edu	37	13	108959245	108959245	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr13:108959245G>A	uc001vqr.2	+	6	1084	c.817G>A	c.(817-819)GAT>AAT	p.D273N	TNFSF13B_uc010agj.2_Missense_Mutation_p.D254N	NM_006573	NP_006564	Q9Y275	TN13B_HUMAN	tumor necrosis factor superfamily, member 13b	273	Extracellular (Potential).				cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding				0	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			AATATCACTGGATGGAGATGT	0.383000												
RNASE9	390443	broad.mit.edu	37	14	21024673	21024673	+	Missense_Mutation	SNP	C	C	A	rs149710160		TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr14:21024673C>A	uc010aho.2	-	4	715	c.556G>T	c.(556-558)GTG>TTG	p.V186L	RNASE9_uc001vxq.3_Missense_Mutation_p.V191L|RNASE9_uc010ahp.2_Missense_Mutation_p.V191L|RNASE9_uc010ahq.2_Missense_Mutation_p.V191L|RNASE9_uc010ahr.2_Missense_Mutation_p.V191L|RNASE9_uc010ahs.2_Missense_Mutation_p.V186L|RNASE9_uc010aht.2_Missense_Mutation_p.V186L|RNASE9_uc010ahu.2_Missense_Mutation_p.V186L	NM_001110357	NP_001103827	P60153	RNAS9_HUMAN	ribonuclease, RNase A family, 9 (non-active)	186						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(2)	2	all_cancers(95;0.00238)		Epithelial(56;3.32e-06)|all cancers(55;2.46e-05)	GBM - Glioblastoma multiforme(265;0.0141)		GGTGGCTCCACGAGATCATTT	0.428000												
FRMD6	122786	broad.mit.edu	37	14	52186866	52186866	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr14:52186866C>T	uc001wzd.2	+	11	1403	c.1118C>T	c.(1117-1119)GCG>GTG	p.A373V	FRMD6_uc001wzb.2_Missense_Mutation_p.A365V|FRMD6_uc001wzc.2_Missense_Mutation_p.A365V|FRMD6_uc001wze.2_Missense_Mutation_p.A296V|FRMD6_uc001wzf.2_Missense_Mutation_p.A66V|FRMD6_uc001wzg.2_Missense_Mutation_p.A15V	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	373						cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					GGGAGCAGTGCGGGCAGCATG	0.607000												
DDHD1	80821	broad.mit.edu	37	14	53560062	53560062	+	Silent	SNP	T	T	C			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr14:53560062T>C	uc001xai.2	-	3	1343	c.1113A>G	c.(1111-1113)ACA>ACG	p.T371T	DDHD1_uc001xaj.2_Silent_p.T378T|DDHD1_uc001xah.2_Silent_p.T371T|DDHD1_uc001xag.2_5'UTR	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	371					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					TTTGGGTAACTGTTCTTGCAA	0.333000												
ZFYVE1	53349	broad.mit.edu	37	14	73441486	73441486	+	Splice_Site	SNP	C	C	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr14:73441486C>G	uc001xnm.2	-	10	2627	c.1987_splice	c.e10+1	p.A663_splice	ZFYVE1_uc001xnl.2_Splice_Site_p.A248_splice|ZFYVE1_uc010arj.2_Splice_Site_p.A649_splice	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1							endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		TCCCACGTTACCTAACTGGAC	0.602000												
SERPINA5	5104	broad.mit.edu	37	14	95053780	95053780	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr14:95053780G>A	uc001ydm.2	+	3	291	c.81G>A	c.(79-81)ATG>ATA	p.M27I	SERPINA5_uc010ave.2_Missense_Mutation_p.M27I|SERPINA5_uc001ydn.1_Missense_Mutation_p.M27I	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	27					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	CCCGGGAGATGAAGAAGAGAG	0.612000												
MNS1	55329	broad.mit.edu	37	15	56726358	56726358	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr15:56726358C>T	uc002adr.2	-	8	1412	c.1247G>A	c.(1246-1248)CGC>CAC	p.R416H	MNS1_uc010bfo.2_Missense_Mutation_p.R284H|TEX9_uc002adp.2_Intron|TEX9_uc010ugl.1_Intron	NM_018365	NP_060835	Q8NEH6	MNS1_HUMAN	meiosis-specific nuclear structural 1	416					meiosis					ovary(1)	1				all cancers(107;0.0196)|GBM - Glioblastoma multiforme(80;0.101)		GAATTGTTGGCGACGCTCTTC	0.348000												
TMEM202	338949	broad.mit.edu	37	15	72691142	72691142	+	Missense_Mutation	SNP	T	T	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr15:72691142T>G	uc002auq.2	+	2	230	c.230T>G	c.(229-231)CTG>CGG	p.L77R	TMEM202_uc002aur.2_Intron	NM_001080462	NP_001073931	A6NGA9	TM202_HUMAN	transmembrane protein 202	77						integral to membrane				central_nervous_system(1)|skin(1)	2						ATGTCCCCACTGAACTGGGTA	0.532000												
CD276	80381	broad.mit.edu	37	15	73996565	73996565	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr15:73996565G>A	uc002avv.1	+	6	1355	c.1121G>A	c.(1120-1122)CGG>CAG	p.R374Q	CD276_uc010bjd.1_Missense_Mutation_p.R228Q|CD276_uc002avu.1_Missense_Mutation_p.R374Q|CD276_uc002avw.1_Missense_Mutation_p.R156Q|CD276_uc010ulb.1_Missense_Mutation_p.R320Q|CD276_uc002avx.2_RNA	NM_001024736	NP_001019907	Q5ZPR3	CD276_HUMAN	CD276 antigen isoform a	374	Extracellular (Potential).|Ig-like C2-type 2.				cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			skin(1)	1						AAGGACCTGCGGCCAGGGGAC	0.652000												
RASGRF1	5923	broad.mit.edu	37	15	79296145	79296145	+	Missense_Mutation	SNP	C	C	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr15:79296145C>G	uc002beq.2	-	16	2871	c.2496G>C	c.(2494-2496)CAG>CAC	p.Q832H	RASGRF1_uc002bep.2_Missense_Mutation_p.Q816H|RASGRF1_uc010blm.1_Missense_Mutation_p.Q741H|RASGRF1_uc002ber.3_Missense_Mutation_p.Q816H|RASGRF1_uc010unh.1_Missense_Mutation_p.Q227H|RASGRF1_uc002beo.2_Missense_Mutation_p.Q48H	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	834					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						GCCACTCACTCTGCTTGCTGA	0.627000												
ASB7	140460	broad.mit.edu	37	15	101169989	101169989	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr15:101169989G>A	uc002bwk.2	+	5	1328	c.559G>A	c.(559-561)GCC>ACC	p.A187T	ASB7_uc002bwj.2_Missense_Mutation_p.A187T	NM_198243	NP_937886	Q9H672	ASB7_HUMAN	ankyrin repeat and SOCS box-containing protein 7	187	ANK 6.				intracellular signal transduction					skin(1)	1	Lung NSC(78;0.00121)|all_lung(78;0.00152)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00168)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			GTTGCGATACGCCGTGATCAA	0.483000												
OR4F6	390648	broad.mit.edu	37	15	102346572	102346572	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr15:102346572C>T	uc010utr.1	+	1	650	c.650C>T	c.(649-651)TCT>TTT	p.S217F		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			CTCATAATCTCTTACATCTTT	0.368000												
PKD1	5310	broad.mit.edu	37	16	2161261	2161261	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr16:2161261C>T	uc002cos.1	-	15	4116	c.3907G>A	c.(3907-3909)GCC>ACC	p.A1303T	PKD1_uc002cot.1_Missense_Mutation_p.A1303T	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1303	PKD 8.|Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GGGATGCAGGCGGCGGGTTCA	0.706000												
ALG1	56052	broad.mit.edu	37	16	5125503	5125503	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr16:5125503G>A	uc002cym.2	+	4	546	c.505G>A	c.(505-507)GGC>AGC	p.G169S	ALG1_uc002cyj.2_Missense_Mutation_p.G58S|ALG1_uc002cyn.2_Missense_Mutation_p.G169S|ALG1_uc010bue.2_Missense_Mutation_p.G58S|ALG1_uc010uxy.1_Missense_Mutation_p.G58S	NM_019109	NP_061982	Q9BT22	ALG1_HUMAN	beta-1,4-mannosyltransferase	169	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)				TCTGGTGCATGGCCCCAACCA	0.542000												
CHD9	80205	broad.mit.edu	37	16	53321899	53321899	+	Silent	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr16:53321899C>T	uc002ehb.2	+	26	5384	c.5220C>T	c.(5218-5220)GCC>GCT	p.A1740A	CHD9_uc002egy.2_Silent_p.A1740A|CHD9_uc002ehc.2_Silent_p.A1740A|CHD9_uc002ehf.2_Silent_p.A854A|CHD9_uc010cbw.2_Silent_p.A108A	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1740					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				ACAAACCTGCCCCAGCCATCT	0.323000												
CDH1	999	broad.mit.edu	37	16	68845649	68845649	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr16:68845649G>T	uc002ewg.1	+	7	1019	c.895G>T	c.(895-897)GCC>TCC	p.A299S	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.A299S	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	299	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		CTACAATGCCGCCATCGCTTA	0.502000			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer			
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	rs11540652		TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572000	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
MYH4	4622	broad.mit.edu	37	17	10369949	10369949	+	Silent	SNP	G	G	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr17:10369949G>T	uc002gmn.2	-	3	225	c.114C>A	c.(112-114)GTC>GTA	p.V38V	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	38	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CCACCACAAAGACTGATGTCT	0.507000												
NCOR1	9611	broad.mit.edu	37	17	15989742	15989742	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr17:15989742G>A	uc002gpo.2	-	23	3271	c.3031C>T	c.(3031-3033)CCA>TCA	p.P1011S	NCOR1_uc002gpn.2_Missense_Mutation_p.P1027S|NCOR1_uc002gpp.1_Missense_Mutation_p.P918S|NCOR1_uc002gpq.1_Missense_Mutation_p.P103S	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1011	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		ACTTGATGTGGAGCAGGCTGA	0.443000												
EFTUD2	9343	broad.mit.edu	37	17	42931680	42931680	+	Missense_Mutation	SNP	T	T	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr17:42931680T>G	uc002ihn.2	-	23	2565	c.2304A>C	c.(2302-2304)CAA>CAC	p.Q768H	EFTUD2_uc010wje.1_Missense_Mutation_p.Q733H|EFTUD2_uc010wjf.1_Missense_Mutation_p.Q758H	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	768						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				ACTGGAAACCTTGAACGATGC	0.562000												
KIAA1267	284058	broad.mit.edu	37	17	44249491	44249491	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr17:44249491C>T	uc002ikb.2	-	1	104	c.19G>A	c.(19-21)GCT>ACT	p.A7T	KIAA1267_uc002ikc.2_Missense_Mutation_p.A7T|KIAA1267_uc002ikd.2_Missense_Mutation_p.A7T|KIAA1267_uc010dav.2_Missense_Mutation_p.A7T	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	7						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				TCAGTGAGAGCGGGCGCCATC	0.622000												
EPX	8288	broad.mit.edu	37	17	56270828	56270828	+	Silent	SNP	C	C	T	rs138191637		TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr17:56270828C>T	uc002ivq.2	+	3	353	c.267C>T	c.(265-267)GCC>GCT	p.A89A		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	89					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						TTGTTCGGGCCGCAGATTATA	0.572000												
LAMA1	284217	broad.mit.edu	37	18	7037734	7037734	+	Missense_Mutation	SNP	C	C	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr18:7037734C>G	uc002knm.2	-	12	1674	c.1580G>C	c.(1579-1581)GGG>GCG	p.G527A	LAMA1_uc010wzj.1_Missense_Mutation_p.G3A	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	527	Laminin IV type A 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GACCAGCCACCCGGACATACT	0.453000												
ESCO1	114799	broad.mit.edu	37	18	19110421	19110421	+	Missense_Mutation	SNP	G	G	C			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr18:19110421G>C	uc002kth.1	-	12	3340	c.2406C>G	c.(2404-2406)AGC>AGG	p.S802R	ESCO1_uc002kti.1_RNA	NM_052911	NP_443143	Q5FWF5	ESCO1_HUMAN	establishment of cohesion 1 homolog 1	802					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding				0						TTTCTTCTTTGCTCAAATATG	0.333000												
ZNF521	25925	broad.mit.edu	37	18	22671939	22671939	+	Silent	SNP	G	G	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr18:22671939G>T	uc002kvk.2	-	6	4012	c.3765C>A	c.(3763-3765)ACC>ACA	p.T1255T	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.T1255T|ZNF521_uc002kvl.2_Silent_p.T1035T	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1255					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GACACTTGAAGGTGCCTCCCA	0.498000			T	PAX5	ALL							
DSG4	147409	broad.mit.edu	37	18	28983413	28983413	+	Silent	SNP	T	T	C			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr18:28983413T>C	uc002kwq.2	+	11	1587	c.1452T>C	c.(1450-1452)TGT>TGC	p.C484C	DSG4_uc002kwr.2_Silent_p.C484C	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	484	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GAACCATATGTATTGAGGTTC	0.388000												
NEDD4L	23327	broad.mit.edu	37	18	55996338	55996338	+	Silent	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr18:55996338G>A	uc002lgy.2	+	10	1066	c.792G>A	c.(790-792)TCG>TCA	p.S264S	NEDD4L_uc002lgz.2_Silent_p.S264S|NEDD4L_uc002lgx.2_Silent_p.S264S|NEDD4L_uc010xee.1_Silent_p.S143S|NEDD4L_uc002lhc.2_Silent_p.S256S|NEDD4L_uc002lhd.2_Silent_p.S143S|NEDD4L_uc002lhb.2_Silent_p.S143S|NEDD4L_uc002lhe.2_Silent_p.S256S|NEDD4L_uc002lhf.2_Silent_p.S143S|NEDD4L_uc002lhg.2_Silent_p.S143S|NEDD4L_uc002lhh.2_Silent_p.S143S|NEDD4L_uc010dpm.1_Silent_p.S115S	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	264					cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						CCGAGCCCTCGGAGGGCGGGG	0.572000												
WDR18	57418	broad.mit.edu	37	19	992107	992107	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr19:992107G>A	uc002lqm.1	+	8	1110	c.1084G>A	c.(1084-1086)GGC>AGC	p.G362S	WDR18_uc002lqn.1_RNA|WDR18_uc010drx.1_Missense_Mutation_p.G325S|WDR18_uc010dry.1_Missense_Mutation_p.G362S	NM_024100	NP_077005	Q9BV38	WDR18_HUMAN	WD repeat domain 18	362										skin(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGCGCCTGGGCCTCCACCA	0.716000												
TUBB4	10382	broad.mit.edu	37	19	6496043	6496043	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr19:6496043C>T	uc002mfg.1	-	4	574	c.467G>A	c.(466-468)CGC>CAC	p.R156H	TUBB4_uc002mff.1_Missense_Mutation_p.R84H|MIR220B_hsa-mir-220b|MI0005529_RNA	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	156					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		GAACTCCTCGCGGATCTTACT	0.637000												
LASS4	79603	broad.mit.edu	37	19	8316115	8316115	+	Missense_Mutation	SNP	T	T	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr19:8316115T>A	uc002mjg.2	+	3	475	c.155T>A	c.(154-156)ATG>AAG	p.M52K	LASS4_uc002mjh.2_Missense_Mutation_p.M1K|LASS4_uc002mji.2_Intron|LASS4_uc010dvz.2_Missense_Mutation_p.M52K	NM_024552	NP_078828	Q9HA82	CERS4_HUMAN	LAG1 homolog, ceramide synthase 4	52	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(1)	1						CTCCTGGCCATGCGCCTTGCC	0.622000												
ZNF85	7639	broad.mit.edu	37	19	21132969	21132969	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr19:21132969C>T	uc002npg.3	+	4	1776	c.1649C>T	c.(1648-1650)TCC>TTC	p.S550F	ZNF85_uc010ecn.2_Missense_Mutation_p.S485F|ZNF85_uc010eco.2_Missense_Mutation_p.S498F|ZNF85_uc002npi.2_Missense_Mutation_p.S491F	NM_003429	NP_003420	Q03923	ZNF85_HUMAN	zinc finger protein 85	550	C2H2-type 15.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)	1						TTTAACCAGTCCTCAAACCTT	0.348000												
ZNF208	7757	broad.mit.edu	37	19	22154592	22154592	+	Nonsense_Mutation	SNP	C	C	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr19:22154592C>A	uc002nqp.2	-	6	3009	c.2860G>T	c.(2860-2862)GAG>TAG	p.E954*	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAGGGTTCCTCTCCAGCATGA	0.438000												
WDR88	126248	broad.mit.edu	37	19	33628609	33628609	+	Silent	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr19:33628609C>T	uc002nui.2	+	2	381	c.303C>T	c.(301-303)CAC>CAT	p.H101H		NM_173479	NP_775750	Q6ZMY6	WDR88_HUMAN	PQQ repeat and WD repeat domain containing	101	WD 1.									ovary(1)|breast(1)|central_nervous_system(1)	3	Esophageal squamous(110;0.137)					TGAGTGGGCACGAGCACGCTG	0.408000												
WDR88	126248	broad.mit.edu	37	19	33651380	33651380	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr19:33651380G>A	uc002nui.2	+	8	1136	c.1058G>A	c.(1057-1059)GGC>GAC	p.G353D		NM_173479	NP_775750	Q6ZMY6	WDR88_HUMAN	PQQ repeat and WD repeat domain containing	353	WD 6.									ovary(1)|breast(1)|central_nervous_system(1)	3	Esophageal squamous(110;0.137)					GTAGCAGAAGGCTACCGGAAG	0.438000												
ZNF382	84911	broad.mit.edu	37	19	37118196	37118196	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr19:37118196G>T	uc002oek.2	+	5	1510	c.1397G>T	c.(1396-1398)TGT>TTT	p.C466F	ZNF382_uc010efa.2_Missense_Mutation_p.C417F|ZNF382_uc010efb.2_Missense_Mutation_p.C465F|ZNF382_uc002oel.2_Missense_Mutation_p.C465F	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	466	Required for transcriptional repression activity; probably mediates sequence- specific DNA-binding (By similarity).|C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CCCTATATTTGTAATGAATGT	0.448000												
LTBP4	8425	broad.mit.edu	37	19	41119862	41119862	+	Silent	SNP	C	C	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr19:41119862C>G	uc002ooh.1	+	21	2799	c.2799C>G	c.(2797-2799)GGC>GGG	p.G933G	LTBP4_uc002oog.1_Silent_p.G896G|LTBP4_uc002ooi.1_Silent_p.G866G|LTBP4_uc002ooj.1_5'UTR|LTBP4_uc002ook.1_Silent_p.G153G|LTBP4_uc002ool.1_Silent_p.G31G|LTBP4_uc002oom.1_RNA|LTBP4_uc010xvp.1_5'Flank	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	933	Cys-rich.|EGF-like 11; calcium-binding (Potential).				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCCAGAGCGGCATCTGTACCA	0.692000												
NLRP7	199713	broad.mit.edu	37	19	55450893	55450893	+	Nonsense_Mutation	SNP	G	G	A	rs104895530		TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr19:55450893G>A	uc002qih.3	-	4	1370	c.1294C>T	c.(1294-1296)CGA>TGA	p.R432*	NLRP7_uc002qig.3_Nonsense_Mutation_p.R432*|NLRP7_uc002qii.3_Nonsense_Mutation_p.R432*|NLRP7_uc010esk.2_Nonsense_Mutation_p.R432*|NLRP7_uc010esl.2_Nonsense_Mutation_p.R460*	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	432	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		AGGTCCTCTCGGTGGAACACG	0.687000												
ZNF471	57573	broad.mit.edu	37	19	57036978	57036978	+	Silent	SNP	T	T	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr19:57036978T>G	uc002qnh.2	+	5	1675	c.1542T>G	c.(1540-1542)CCT>CCG	p.P514P		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	514					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		GAGAGAAGCCTTATGAATGTA	0.373000												
ZNF132	7691	broad.mit.edu	37	19	58944765	58944765	+	Silent	SNP	A	A	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr19:58944765A>G	uc002qst.3	-	3	2447	c.2046T>C	c.(2044-2046)ACT>ACC	p.T682T		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	682						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		TACACTCATAAGTCCTTTCTC	0.443000												
E2F6	1876	broad.mit.edu	37	2	11587867	11587867	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr2:11587867C>T	uc002rbh.2	-	6	977	c.685G>A	c.(685-687)GGA>AGA	p.G229R	E2F6_uc002rbe.2_Missense_Mutation_p.G154R|E2F6_uc002rbf.2_Missense_Mutation_p.G197R|E2F6_uc002rbg.2_Missense_Mutation_p.G154R|E2F6_uc002rbi.2_Missense_Mutation_p.G154R|E2F6_uc010yjl.1_RNA	NM_198256	NP_937987	O75461	E2F6_HUMAN	E2F transcription factor 6	229	Transcription repression.			G -> E (in Ref. 8; AAC14694).	negative regulation of transcription from RNA polymerase II promoter	MLL1 complex|transcription factor complex	DNA binding|transcription corepressor activity			skin(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.114)|OV - Ovarian serous cystadenocarcinoma(76;0.168)		TCGATAGGTCCGTTGGTGCTC	0.433000												
CAD	790	broad.mit.edu	37	2	27440776	27440776	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr2:27440776G>T	uc002rji.2	+	2	276	c.114G>T	c.(112-114)GAG>GAT	p.E38D	CAD_uc010eyw.2_Missense_Mutation_p.E38D	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	38	GATase (Glutamine amidotransferase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GCTACCCCGAGGCCCTCACCG	0.587000												
MSH2	4436	broad.mit.edu	37	2	47657028	47657028	+	Nonsense_Mutation	SNP	T	T	G	rs63750132		TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr2:47657028T>G	uc002rvy.1	+	7	1292	c.1224T>G	c.(1222-1224)TAT>TAG	p.Y408*	MSH2_uc010yoh.1_Nonsense_Mutation_p.Y342*|MSH2_uc002rvz.2_Nonsense_Mutation_p.Y408*|MSH2_uc010fbg.2_Nonsense_Mutation_p.Y218*	NM_000251	NP_000242	P43246	MSH2_HUMAN	mutS homolog 2	408					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.?(1)		large_intestine(33)|haematopoietic_and_lymphoid_tissue(6)|endometrium(4)|ovary(3)|cervix(2)|central_nervous_system(2)|stomach(1)|small_intestine(1)|breast(1)|skin(1)|prostate(1)	55		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ACCGACTCTATCAGGGTATAA	0.348000			D|Mis|N|F|S		colorectal|endometrial|ovarian	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome			
NRXN1	9378	broad.mit.edu	37	2	50280681	50280681	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr2:50280681C>T	uc010fbp.2	-	4	1468	c.661G>A	c.(661-663)GGG>AGG	p.G221R	NRXN1_uc002rxb.3_Missense_Mutation_p.G958R|NRXN1_uc010fbq.2_Missense_Mutation_p.G1326R|NRXN1_uc002rxe.3_Missense_Mutation_p.G1256R	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	221	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TGCTCTTTCCCGCCAATTATT	0.448000												
IL18R1	8809	broad.mit.edu	37	2	102992506	102992506	+	Missense_Mutation	SNP	A	A	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr2:102992506A>G	uc002tbw.3	+	5	758	c.608A>G	c.(607-609)AAT>AGT	p.N203S	IL18R1_uc010ywc.1_Missense_Mutation_p.N203S|IL18R1_uc010ywd.1_Missense_Mutation_p.N48S|IL18R1_uc010fiy.2_Missense_Mutation_p.N203S	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	203	Ig-like C2-type 2.|Extracellular (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			ovary(2)|pancreas(1)	3						AAAACCTTCAATATAACAATA	0.338000												
OSBPL6	114880	broad.mit.edu	37	2	179197640	179197640	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr2:179197640C>T	uc002ulx.2	+	8	907	c.529C>T	c.(529-531)CGA>TGA	p.R177*	OSBPL6_uc002ulw.2_Nonsense_Mutation_p.R177*|OSBPL6_uc002uly.2_Nonsense_Mutation_p.R177*|OSBPL6_uc010zfe.1_Nonsense_Mutation_p.R177*|OSBPL6_uc002ulz.2_Nonsense_Mutation_p.R177*|OSBPL6_uc002uma.2_Nonsense_Mutation_p.R156*	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	177	PH.				lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			CTCCAAACTGCGACATCATCG	0.433000												
TTN	7273	broad.mit.edu	37	2	179669352	179669352	+	Silent	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr2:179669352C>T	uc002und.2	-	2	243	c.18G>A	c.(16-18)CCG>CCA	p.P6P	TTN_uc010zfg.1_Silent_p.P6P|TTN_uc010zfh.1_Silent_p.P6P|TTN_uc010zfi.1_Silent_p.P6P|TTN_uc010zfj.1_Silent_p.P6P|TTN_uc002unb.2_Silent_p.P6P			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	6							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCGTAAACGTCGGTGCTTGAG	0.463000												
TGM6	343641	broad.mit.edu	37	20	2398117	2398117	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr20:2398117C>T	uc002wfy.1	+	10	1637	c.1576C>T	c.(1576-1578)CGG>TGG	p.R526W	TGM6_uc010gal.1_Missense_Mutation_p.R526W	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	526					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CCGGGCCCAGCGGGTGAGGGT	0.647000												
SSTR4	6754	broad.mit.edu	37	20	23016224	23016224	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr20:23016224C>T	uc002wsr.2	+	1	168	c.104C>T	c.(103-105)GCG>GTG	p.A35V		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	35	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GCGGAGGAGGCGGTggcgggg	0.612000												
CHMP4B	128866	broad.mit.edu	37	20	32436452	32436452	+	Splice_Site	SNP	T	T	C			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr20:32436452T>C	uc002xaa.2	+	2	524	c.368_splice	c.e2+2	p.M123_splice		NM_176812	NP_789782	Q9H444	CHM4B_HUMAN	chromatin modifying protein 4B						cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			ovary(1)|central_nervous_system(1)	2						TGACAACATGTACGTGTCCAC	0.612000												
ARFGEF2	10564	broad.mit.edu	37	20	47633918	47633918	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr20:47633918C>T	uc002xtx.3	+	32	4600	c.4448C>T	c.(4447-4449)CCA>CTA	p.P1483L	ARFGEF2_uc010zyf.1_Missense_Mutation_p.P776L	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1483					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			ACAACCATCCCACATGTGTAA	0.373000												
ZNF512B	57473	broad.mit.edu	37	20	62591290	62591290	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr20:62591290C>T	uc002yhl.1	-	17	2684	c.2630G>A	c.(2629-2631)CGG>CAG	p.R877Q		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	877					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GGTGGAGCCCCGGGCCCCCTT	0.711000												
CSF2RB	1439	broad.mit.edu	37	22	37331476	37331476	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr22:37331476G>A	uc003aqa.3	+	11	1616	c.1399G>A	c.(1399-1401)GGG>AGG	p.G467R	CSF2RB_uc003aqc.3_Missense_Mutation_p.G473R	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	467	Cytoplasmic (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	TGGCATCTACGGGTACAGGTG	0.662000												
MICALL1	85377	broad.mit.edu	37	22	38323469	38323469	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr22:38323469C>T	uc003aui.2	+	9	1601	c.1517C>T	c.(1516-1518)TCG>TTG	p.S506L		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	molecule interacting with Rab13	506	Pro-rich.					cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)	1	Melanoma(58;0.045)					GCCACACCATCGCCAGCGCTC	0.677000												
BAP1	8314	broad.mit.edu	37	3	52443593	52443593	+	Nonsense_Mutation	SNP	G	G	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr3:52443593G>T	uc003ddx.2	-	3	214	c.99C>A	c.(97-99)TAC>TAA	p.Y33*	PHF7_uc003ddy.2_5'Flank|PHF7_uc003ddz.2_5'Flank	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	33					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		TCTGAAGGTCGTAGATCTCCT	0.612000			N|Mis|F|S|O		uveal melanoma|breast|NSCLC							
LRIG1	26018	broad.mit.edu	37	3	66436708	66436708	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr3:66436708G>A	uc003dmx.2	-	13	1500	c.1486C>T	c.(1486-1488)CAG>TAG	p.Q496*	SLC25A26_uc011bft.1_RNA|LRIG1_uc011bfu.1_Nonsense_Mutation_p.Q116*|LRIG1_uc003dmw.2_Nonsense_Mutation_p.Q162*|LRIG1_uc010hnz.2_Nonsense_Mutation_p.Q212*|LRIG1_uc010hoa.2_Nonsense_Mutation_p.Q520*	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	496	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GTGATGATCTGTGGCTTCAGG	0.537000												
KIAA2018	205717	broad.mit.edu	37	3	113376724	113376724	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr3:113376724C>T	uc003eam.2	-	7	4216	c.3805G>A	c.(3805-3807)GTG>ATG	p.V1269M	KIAA2018_uc003eal.2_Missense_Mutation_p.V1213M	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1269					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GTTGCAGGCACAGTTGTTTGC	0.468000												
STAG1	10274	broad.mit.edu	37	3	136096538	136096538	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr3:136096538C>A	uc003era.1	-	23	2626	c.2334G>T	c.(2332-2334)CAG>CAT	p.Q778H	STAG1_uc003erb.1_Missense_Mutation_p.Q778H|STAG1_uc003erc.1_Missense_Mutation_p.Q552H	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	778					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						TAGACAGGCACTGCTGGCAAA	0.358000												
CEP70	80321	broad.mit.edu	37	3	138248265	138248265	+	Silent	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr3:138248265G>A	uc003esl.2	-	9	930	c.732C>T	c.(730-732)AAC>AAT	p.N244N	CEP70_uc011bmk.1_Silent_p.N224N|CEP70_uc011bml.1_Silent_p.N226N|CEP70_uc011bmm.1_Silent_p.N92N|CEP70_uc003esm.2_Silent_p.N244N	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	244					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						TTCTGTAGTCGTTTTCTTCTT	0.289000												
RSRC1	51319	broad.mit.edu	37	3	157920896	157920896	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr3:157920896G>T	uc003fbt.2	+	4	467	c.356G>T	c.(355-357)CGT>CTT	p.R119L	RSRC1_uc011bou.1_Intron|RSRC1_uc003fbu.1_Missense_Mutation_p.R119L|RSRC1_uc003fbv.2_Intron	NM_016625	NP_057709	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	119	Arg/Ser-rich.				nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding				0			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			TCTCATAGTCGTAGCAGTGAA	0.378000												
FXR1	8087	broad.mit.edu	37	3	180685947	180685947	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr3:180685947G>A	uc003fkq.2	+	14	1329	c.1307G>A	c.(1306-1308)CGT>CAT	p.R436H	FXR1_uc003fkp.2_Missense_Mutation_p.R351H|FXR1_uc003fkr.2_Missense_Mutation_p.R436H|FXR1_uc011bqj.1_Missense_Mutation_p.R350H|FXR1_uc003fks.2_Missense_Mutation_p.R379H|FXR1_uc011bqk.1_Missense_Mutation_p.R387H|FXR1_uc011bql.1_Missense_Mutation_p.R423H	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	436					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			CGACATCAGCGTGACAGCAGG	0.547000												
MFSD7	84179	broad.mit.edu	37	4	680390	680390	+	Nonsense_Mutation	SNP	G	G	C			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr4:680390G>C	uc003gay.2	-	2	282	c.225C>G	c.(223-225)TAC>TAG	p.Y75*	MFSD7_uc003gaw.2_5'Flank|MFSD7_uc003gax.2_Nonsense_Mutation_p.Y75*|MFSD7_uc003gaz.2_Nonsense_Mutation_p.Y53*|MFSD7_uc003gba.2_Nonsense_Mutation_p.Y75*|MFSD7_uc003gbb.1_Nonsense_Mutation_p.Y11*	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	75	Helical; (Potential).				transmembrane transport	integral to membrane					0						ATACCACGAGGTAGACCAGTG	0.627000												
DCAF4L1	285429	broad.mit.edu	37	4	41984892	41984892	+	Silent	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr4:41984892C>T	uc003gwk.2	+	1	1180	c.1083C>T	c.(1081-1083)GAC>GAT	p.D361D		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	361										skin(1)	1						CCTCCGAGGACGACATTCCCA	0.627000												
KCTD8	386617	broad.mit.edu	37	4	44450216	44450216	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr4:44450216C>T	uc003gwu.2	-	1	609	c.325G>A	c.(325-327)GTG>ATG	p.V109M		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	109	BTB.					cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						TAATCCAGCACGTACCTGAAA	0.567000										HNSCC(17;0.042)		
NEUROG2	63973	broad.mit.edu	37	4	113436204	113436204	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr4:113436204G>A	uc003ias.2	-	2	755	c.428C>T	c.(427-429)CCC>CTC	p.P143L		NM_024019	NP_076924	Q9H2A3	NGN2_HUMAN	neurogenin 2	143	Helix-loop-helix motif.				positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent	nucleus	E-box binding			skin(2)|central_nervous_system(1)	3		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00168)		GGCGTCCTCGGGGAACGTGGG	0.607000												
KIAA1109	84162	broad.mit.edu	37	4	123192559	123192559	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr4:123192559G>A	uc003ieh.2	+	45	7925	c.7880G>A	c.(7879-7881)GGA>GAA	p.G2627E	KIAA1109_uc003iel.1_Missense_Mutation_p.G562E|KIAA1109_uc003iek.2_Missense_Mutation_p.G1246E	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2627					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGTTCTAGAGGAAGTCTTAAT	0.403000												
ZNF827	152485	broad.mit.edu	37	4	146686173	146686173	+	Missense_Mutation	SNP	T	T	C			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr4:146686173T>C	uc003ikn.2	-	13	3245	c.3197A>G	c.(3196-3198)AAG>AGG	p.K1066R	ZNF827_uc003ikm.2_Missense_Mutation_p.K1066R|ZNF827_uc010iox.2_Missense_Mutation_p.K716R|ZNF827_uc003ikl.2_Missense_Mutation_p.K151R	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	1066	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					GTGGCATTTCTTATGCTCCAG	0.493000												
EDNRA	1909	broad.mit.edu	37	4	148463689	148463689	+	Silent	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr4:148463689C>T	uc003iky.2	+	8	1895	c.1203C>T	c.(1201-1203)AAC>AAT	p.N401N	EDNRA_uc011cid.1_Silent_p.N176N|EDNRA_uc010ipf.1_RNA|EDNRA_uc010ipg.1_Silent_p.N292N	NM_001957	NP_001948	P25101	EDNRA_HUMAN	endothelin receptor type A isoform a precursor	401	Cytoplasmic (Potential).				activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|breast(1)	2	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	TCCCCATGAACGGAACAAGCA	0.532000												
LMBRD2	92255	broad.mit.edu	37	5	36137532	36137532	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr5:36137532G>A	uc003jkb.1	-	5	795	c.380C>T	c.(379-381)CCT>CTT	p.P127L		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	127	Cytoplasmic (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTGCATAAAAGGTAAGAGAAT	0.333000												
ST8SIA4	7903	broad.mit.edu	37	5	100147763	100147763	+	Nonsense_Mutation	SNP	T	T	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr5:100147763T>A	uc003knk.2	-	5	1196	c.868A>T	c.(868-870)AGA>TGA	p.R290*		NM_005668	NP_005659	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide	290	Lumenal (Potential).				axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			large_intestine(1)|central_nervous_system(1)	2		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		TCACAGAATCTTGTGGCAAGT	0.363000												
PCDHB10	56126	broad.mit.edu	37	5	140573656	140573656	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr5:140573656G>A	uc003lix.2	+	1	1705	c.1531G>A	c.(1531-1533)GGC>AGC	p.G511S		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	511	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCGGACAACGGCCACCTGTT	0.692000												
PCDHGB4	8641	broad.mit.edu	37	5	140769437	140769437	+	Silent	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr5:140769437C>T	uc003lkc.1	+	1	1986	c.1986C>T	c.(1984-1986)TTC>TTT	p.F662F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Silent_p.F662F	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	662	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTGGTCTTCGCCGACAGCT	0.657000												
PCDHGB6	56100	broad.mit.edu	37	5	140788444	140788444	+	Silent	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr5:140788444C>T	uc003lkj.1	+	1	675	c.675C>T	c.(673-675)ACC>ACT	p.T225T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Silent_p.T225T	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	225	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGTGCCACCGCTCACATAG	0.473000												
ZNF346	23567	broad.mit.edu	37	5	176468802	176468802	+	Silent	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr5:176468802G>A	uc003mfi.2	+	3	346	c.303G>A	c.(301-303)GTG>GTA	p.V101V	ZNF346_uc011dfr.1_Intron|ZNF346_uc011dfs.1_Intron|ZNF346_uc003mfj.2_Intron|ZNF346_uc003mfk.1_Silent_p.V126V|ZNF346_uc011dft.1_Intron	NM_012279	NP_036411	Q9UL40	ZN346_HUMAN	zinc finger protein 346	101	Matrin-type 1.					cytoplasm|nucleolus	double-stranded RNA binding|zinc ion binding				0	all_cancers(89;6.3e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCAACAAAGTGAAGAGATACC	0.413000												
CDC5L	988	broad.mit.edu	37	6	44376302	44376302	+	Missense_Mutation	SNP	A	A	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr6:44376302A>G	uc003oxl.2	+	8	1284	c.1025A>G	c.(1024-1026)AAT>AGT	p.N342S		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	342	Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TCTGAGTACAATGTCACCAAC	0.453000												
MANEA	79694	broad.mit.edu	37	6	96034725	96034725	+	Missense_Mutation	SNP	A	A	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr6:96034725A>G	uc003poo.1	+	2	550	c.410A>G	c.(409-411)AAG>AGG	p.K137R	MANEA_uc003pon.2_Missense_Mutation_p.K137R	NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	137	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		AGAATAGCCAAGAATTATCCA	0.398000												
GHRHR	2692	broad.mit.edu	37	7	31018824	31018824	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr7:31018824C>T	uc003tbx.2	+	13	1285	c.1237C>T	c.(1237-1239)CGC>TGC	p.R413C	GHRHR_uc003tby.2_Missense_Mutation_p.R349C|GHRHR_uc003tbz.2_3'UTR	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	413	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	CACGCCTTCCCGCTCGGCGGC	0.602000												
MAGI2	9863	broad.mit.edu	37	7	77789453	77789453	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr7:77789453C>T	uc003ugx.2	-	16	2988	c.2734G>A	c.(2734-2736)GCC>ACC	p.A912T	MAGI2_uc003ugy.2_Missense_Mutation_p.A898T|MAGI2_uc010ldx.1_Missense_Mutation_p.A505T	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	912						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CTGTGGGAGGCGAAGCCTTCA	0.577000												
PCLO	27445	broad.mit.edu	37	7	82579844	82579844	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr7:82579844C>A	uc003uhx.2	-	6	10349	c.10060G>T	c.(10060-10062)GAT>TAT	p.D3354Y	PCLO_uc003uhv.2_Missense_Mutation_p.D3354Y|PCLO_uc010lec.2_Missense_Mutation_p.D319Y	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3285					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTGGTTGCATCTTCAGTTGCC	0.483000												
SLC26A4	5172	broad.mit.edu	37	7	107314680	107314680	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr7:107314680G>A	uc003vep.2	+	5	711	c.487G>A	c.(487-489)GTA>ATA	p.V163I		NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	163	Extracellular (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						ACACTTTCTCGTATCCAGCAG	0.453000									Pendred_syndrome			
NUP205	23165	broad.mit.edu	37	7	135304191	135304191	+	Silent	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr7:135304191G>A	uc003vsw.2	+	29	4015	c.3984G>A	c.(3982-3984)GCG>GCA	p.A1328A	NUP205_uc003vsx.2_5'Flank	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1328					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						ATGAAGCTGCGCAAGAGTTAA	0.443000												
FGF20	26281	broad.mit.edu	37	8	16850819	16850819	+	Missense_Mutation	SNP	A	A	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr8:16850819A>G	uc003wxc.1	-	3	531	c.398T>C	c.(397-399)CTT>CCT	p.L133P	FGF20_uc010lsv.1_RNA|FGF20_uc010lsw.1_Silent_p.T98T	NM_019851	NP_062825	Q9NP95	FGF20_HUMAN	fibroblast growth factor 20	133					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular region|soluble fraction	growth factor activity			lung(1)	1				Colorectal(111;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		TTCGGAAGTAAGTTTCTCCTG	0.323000												
POP1	10940	broad.mit.edu	37	8	99135655	99135655	+	Missense_Mutation	SNP	A	A	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr8:99135655A>T	uc003yij.3	+	2	190	c.90A>T	c.(88-90)AGA>AGT	p.R30S	POP1_uc011lgv.1_Missense_Mutation_p.R30S|POP1_uc003yik.2_Missense_Mutation_p.R30S	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	30					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			TGGCTGACAGAGGTGTAAAGC	0.353000												
RIMS2	9699	broad.mit.edu	37	8	104898126	104898126	+	Silent	SNP	T	T	C			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr8:104898126T>C	uc003yls.2	+	2	874	c.633T>C	c.(631-633)CCT>CCC	p.P211P	RIMS2_uc003ylp.2_Silent_p.P433P|RIMS2_uc003ylw.2_Silent_p.P241P|RIMS2_uc003ylq.2_Silent_p.P241P|RIMS2_uc003ylr.2_Silent_p.P241P	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	464					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ACCATAGTCCTCCTACCCCCA	0.488000										HNSCC(12;0.0054)		
OC90	729330	broad.mit.edu	37	8	133044144	133044144	+	Silent	SNP	T	T	G			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr8:133044144T>G	uc003ytg.2	-	11	1015	c.1015A>C	c.(1015-1017)AGG>CGG	p.R339R	OC90_uc011lix.1_Silent_p.R339R	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	355	Phospholipase A2-like 2.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			AGGTCATCCCTTGGCTCGCCT	0.557000												
TRPM6	140803	broad.mit.edu	37	9	77354315	77354315	+	Missense_Mutation	SNP	T	T	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr9:77354315T>A	uc004ajl.1	-	35	5776	c.5538A>T	c.(5536-5538)CAA>CAT	p.Q1846H	TRPM6_uc004ajk.1_Missense_Mutation_p.Q1841H|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.Q797H|TRPM6_uc010mpd.1_Missense_Mutation_p.Q679H|TRPM6_uc010mpe.1_Missense_Mutation_p.Q393H|TRPM6_uc004ajj.1_Missense_Mutation_p.Q802H	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1846	Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GTGGTTTCACTTGGTTGAAGG	0.388000												
PTPDC1	138639	broad.mit.edu	37	9	96864034	96864034	+	Splice_Site	SNP	G	G	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr9:96864034G>A	uc004auf.1	+	8	2377	c.2037_splice	c.e8+1	p.K679_splice	PTPDC1_uc004aug.1_Splice_Site_p.K674_splice|PTPDC1_uc004auh.1_Splice_Site_p.K731_splice|PTPDC1_uc010mrj.1_Splice_Site_p.K733_splice	NM_177995	NP_818931	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1								protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1						ATTAGAGAAGGTAAAGTGGCT	0.413000												
IKBKAP	8518	broad.mit.edu	37	9	111674597	111674597	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr9:111674597C>T	uc004bdm.3	-	11	1656	c.1136G>A	c.(1135-1137)CGG>CAG	p.R379Q	IKBKAP_uc004bdl.2_Missense_Mutation_p.R30Q|IKBKAP_uc011lwc.1_Missense_Mutation_p.R265Q|IKBKAP_uc010mtq.2_Missense_Mutation_p.R30Q	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	379					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						TCCCACGCTCCGGTCAGTCGT	0.542000												
PDCL	5082	broad.mit.edu	37	9	125588916	125588916	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr9:125588916C>T	uc004bmz.1	-	2	247	c.151G>A	c.(151-153)GAA>AAA	p.E51K	PDCL_uc004bna.2_Missense_Mutation_p.E51K	NM_005388	NP_005379	Q13371	PHLP_HUMAN	phosducin-like	51					signal transduction|visual perception						0						GAGATGCCTTCGCCTGCCAGC	0.463000												
LAMC3	10319	broad.mit.edu	37	9	133960933	133960933	+	Silent	SNP	G	G	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr9:133960933G>T	uc004caa.1	+	25	4151	c.4053G>T	c.(4051-4053)CGG>CGT	p.R1351R	LAMC3_uc010mze.1_Intron	NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1351	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		AGTTTCCCCGGCCCAAGGACC	0.627000												
AFF2	2334	broad.mit.edu	37	X	147743964	147743964	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chrX:147743964C>T	uc004fcp.2	+	3	1195	c.716C>T	c.(715-717)CCG>CTG	p.P239L	AFF2_uc004fco.2_Missense_Mutation_p.P235L|AFF2_uc004fcq.2_Missense_Mutation_p.P235L|AFF2_uc004fcr.2_Missense_Mutation_p.P235L|AFF2_uc011mxb.1_Missense_Mutation_p.P239L|AFF2_uc004fcs.2_Missense_Mutation_p.P235L	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	239					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TCCAATTCACCGGAAGAATCT	0.453000												
WFIKKN1	117166	broad.mit.edu	37	16	683929	683930	+	Frame_Shift_Ins	INS	-	-	T			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr16:683929_683930insT	uc002cht.1	+	2	1761_1762	c.1519_1520insT	c.(1519-1521)GTGfs	p.V507fs	WFIKKN1_uc002chs.1_3'UTR|uc010uuk.1_5'Flank	NM_053284	NP_444514	Q96NZ8	WFKN1_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz	507	NTR.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity				0		Hepatocellular(780;0.00335)				CATGGGTGAGGTGCGCGATGGC	0.683												
CMPK1	51727	broad.mit.edu	37	1	47834143	47834144	+	Frame_Shift_Ins	INS	-	-	AT			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr1:47834142_47834143A>AAT	uc001cri.3	+	1	322_323	c.173_174A>AAT	c.(172-174)aaafs	p.K58fs	CMPK1_uc010omp.2_Intron|CMPK1_uc010omq.2_Non-coding_Transcript	NM_016308	NP_057392	P30085	KCY_HUMAN	Homo sapiens cytidine monophosphate (UMP-CMP) kinase 1, cytosolic (CMPK1), transcript variant 1, mRNA.	26					nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleus	ATP binding|cytidylate kinase activity|nucleoside phosphate kinase activity|uridine kinase activity			endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|stomach(2)	8					Gemcitabine(DB00441)	TTCTTTCAGAAATATGGCTACA	0.347												
FANCM	57697	broad.mit.edu	37	14	45645902	45645903	+	Frame_Shift_Ins	INS	-	-	A			TCGA-IN-7808-01A-11D-2201-08	TCGA-IN-7808-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be1f362d-e971-44b7-bcbb-6f9847d2089f	ddee461d-502d-40a9-8be0-9d50824f4199	g.chr14:45645901_45645902C>CA	uc001wwd.4	+	13	4043_4044	c.3944_3945C>CA	c.(3943-3945)gcafs	p.A1315fs	FANCM_uc010anf.3_Frame_Shift_Ins_p.A1289fs|FANCM_uc001wwe.4_Frame_Shift_Ins_p.A851fs|FANCM_uc010ang.3_Frame_Shift_Ins_p.A529fs	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Homo sapiens Fanconi anemia, complementation group M (FANCM), mRNA.	1315					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|DNA binding|chromatin binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						CTGAGTGCAGCAAAAAATGAAG	0.327								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia