Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ABCA3	21	broad.mit.edu	37	16	2358593	2358593	+	Silent	SNP	G	G	A			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr16:2358593G>A	uc002cpy.1	-	10	1855	c.1143C>T	c.(1141-1143)ctC>ctT	p.L381L	ABCA3_uc010bsk.1_Intron|ABCA3_uc010bsl.1_Silent_p.L381L	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 3 (ABCA3), mRNA.	381					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				TGAAGAAGTAGAGGAAGCCTC	0.602000													17	67					0	0	1	0	0
B3GNT5	84002	broad.mit.edu	37	3	182988119	182988119	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr3:182988119G>A	uc003flk.3	+	1	1063	c.533G>A	c.(532-534)tGg>tAg	p.W178*	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.3_Nonsense_Mutation_p.W178*|B3GNT5_uc003flm.3_Nonsense_Mutation_p.W178*|B3GNT5_uc021xic.1_Nonsense_Mutation_p.W178*	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (B3GNT5), mRNA.	178					central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CAGTTCAGTTGGGCAAATACC	0.343000													32	95					0	0	1	0	0
ARSK	153642	broad.mit.edu	37	5	94918766	94918766	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr5:94918766G>A	uc003kld.3	+	3	721	c.563G>A	c.(562-564)aGa>aAa	p.R188K	ARSK_uc010jbg.3_Missense_Mutation_p.R29K|ARSK_uc011cum.2_Non-coding_Transcript	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	Homo sapiens arylsulfatase family, member K (ARSK), mRNA.	188						extracellular region	arylsulfatase activity|metal ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(1)	16		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		AACTGGTTAAGAAAGGAAGCA	0.388000													24	64					0	0	1	0	0
SMARCC2	6601	broad.mit.edu	37	12	56571852	56571852	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr12:56571852G>C	uc001skb.3	-	14	1442	c.1336C>G	c.(1336-1338)Ctc>Gtc	p.L446V	SMARCC2_uc001skd.3_Missense_Mutation_p.L446V|SMARCC2_uc001ska.3_Missense_Mutation_p.L446V|SMARCC2_uc001skc.3_Missense_Mutation_p.L446V|SMARCC2_uc010sqf.2_Missense_Mutation_p.L335V	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 (SMARCC2), transcript variant 1, mRNA.	446	SWIRM.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex|nBAF complex|npBAF complex|nucleoplasm	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			AACTCGGGGAGAGCCCTCCGC	0.512000													7	30					0	0	1	0	0
TMTC2	160335	broad.mit.edu	37	12	83289743	83289743	+	Silent	SNP	C	C	T	rs143764076		TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr12:83289743C>T	uc001szt.3	+	2	1233	c.801C>T	c.(799-801)ctC>ctT	p.L267L	TMTC2_uc001szr.1_Silent_p.L267L|TMTC2_uc001szs.1_Silent_p.L267L|TMTC2_uc010suk.2_Silent_p.L22L	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	Homo sapiens transmembrane and tetratricopeptide repeat containing 2 (TMTC2), mRNA.	267						endoplasmic reticulum|integral to membrane	binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|urinary_tract(1)	39						ACAGCCTCCTCACCCGCACTC	0.532000													35	160					0	0	1	0	0
ANKRD44	91526	broad.mit.edu	37	2	197975514	197975514	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr2:197975514G>A	uc021vuj.1	-	8	1154	c.961C>T	c.(961-963)Cgg>Tgg	p.R321W	ANKRD44_uc002utz.4_Missense_Mutation_p.R10W|ANKRD44_uc021vuk.1_Missense_Mutation_p.R296W|ANKRD44_uc002uub.3_Missense_Mutation_p.R321W|ANKRD44_uc010zgw.2_Missense_Mutation_p.R249W|ANKRD44_uc002uuc.3_Missense_Mutation_p.R321W	NM_001195144	NP_001182073	Q8N8A2	ANR44_HUMAN	Homo sapiens ankyrin repeat domain 44 (ANKRD44), transcript variant A, mRNA.	321							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GTCTGTGACCGTGTGAACCTT	0.428000													5	210					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12656261	12656261	+	Silent	SNP	G	G	A			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr17:12656261G>A	uc002gno.2	+	9	1955	c.1656G>A	c.(1654-1656)caG>caA	p.Q552Q	MYOCD_uc002gnn.2_Silent_p.Q552Q|MYOCD_uc002gnp.1_Silent_p.Q456Q|MYOCD_uc002gnq.2_Silent_p.Q271Q	NM_001146312	NP_001139784	Q8IZQ8	MYCD_HUMAN	Homo sapiens myocardin (MYOCD), transcript variant 1, mRNA.	552					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	RNA polymerase II transcription factor binding transcription factor activity|nucleic acid binding|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TTCAGAAGCAGAAAAGGAATA	0.522000													7	51					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123927267	123927267	+	Missense_Mutation	SNP	T	T	A			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr9:123927267T>A	uc004bkx.1	+	32	5501	c.5470T>A	c.(5470-5472)Tta>Ata	p.L1824I	CNTRL_uc004blb.1_Missense_Mutation_p.L493I|CNTRL_uc010mvp.1_5'UTR	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	Homo sapiens centriolin (CNTRL), mRNA.	1824					G2/M transition of mitotic cell cycle|cell division	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						GCAATCAAACTTAGAAAAGTT	0.398000													4	76					0	0	1	0	0
FZD1	8321	broad.mit.edu	37	7	90894813	90894813	+	Silent	SNP	C	C	A			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr7:90894813C>A	uc003ula.3	+	0	1031	c.618C>A	c.(616-618)ggC>ggA	p.G206G		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	Homo sapiens frizzled family receptor 1 (FZD1), mRNA.	206	FZ.				G-protein signaling, coupled to cGMP nucleotide second messenger|Wnt receptor signaling pathway, calcium modulating pathway|autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding|receptor binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			ACAAGTTCGGCTTCCAGTGGC	0.701000													16	56					0	0	1	0	0
ITGB1	3688	broad.mit.edu	37	10	33200886	33200886	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr10:33200886C>T	uc001iwr.4	-	10	1636	c.1636G>A	c.(1636-1638)Gaa>Aaa	p.E546K	ITGB1_uc001iws.4_Missense_Mutation_p.E546K|ITGB1_uc001iwt.4_Missense_Mutation_p.E546K	NM_033668	NP_391988	P05556	ITB1_HUMAN	Homo sapiens integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1D, mRNA.	546	Cysteine-rich tandem repeats.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Ovarian(717;1.34e-05)|Breast(68;0.0634)				GAATAAATTTCATTTGTATTA	0.403000													21	106					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74625777	74625777	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr18:74625777A>G	uc002lmi.3	+	17	3176	c.2978A>G	c.(2977-2979)aAg>aGg	p.K993R	ZNF236_uc002lmj.3_Non-coding_Transcript	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	Homo sapiens zinc finger protein 236 (ZNF236), mRNA.	993					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		ACCGGGGAAAAGCCCTACAAG	0.517000													3	111					0	0	1	0	0
EHD1	10938	broad.mit.edu	37	11	64622296	64622296	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr11:64622296G>C	uc010rnq.1	-	5	1203	c.1156C>G	c.(1156-1158)Cag>Gag	p.Q386E	EHD1_uc021qkz.1_Missense_Mutation_p.Q55E|EHD1_uc001obu.1_Missense_Mutation_p.Q372E|EHD1_uc001obv.1_Missense_Mutation_p.Q372E	NM_006795	NP_006786	Q9H4M9	EHD1_HUMAN	Homo sapiens EH-domain containing 1 (EHD1), mRNA.	372					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|GTP binding|GTPase activity|calcium ion binding|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	12						TTCAGCGCCTGGAACTTGCTG	0.642000													57	209					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92345516	92345516	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr13:92345516C>T	uc010tif.2	+	2	767	c.401C>T	c.(400-402)gCc>gTc	p.A134V		NM_004466	NP_004457	P78333	GPC5_HUMAN	Homo sapiens glypican 5 (GPC5), mRNA.	134						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AGGAACATGGCCTTGGAGGCT	0.403000													20	84					0	0	1	0	0
TNFSF4	7292	broad.mit.edu	37	1	173155920	173155920	+	Missense_Mutation	SNP	T	T	C			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr1:173155920T>C	uc001giw.3	-	2	443	c.287A>G	c.(286-288)aAc>aGc	p.N96S	TNFSF4_uc001giv.3_Missense_Mutation_p.N46S	NM_003326	NP_003317	P23510	TNFL4_HUMAN	Homo sapiens tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4), mRNA.	96					T-helper 2 cell activation|acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of T-helper 1 cell differentiation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell activation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of alpha-beta T cell proliferation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction	cell surface|extracellular space|integral to plasma membrane	cytokine activity			breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|urinary_tract(1)	12						CCCATCACAGTTGATGATGAC	0.458000													21	69					0	0	1	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43651086	43651086	+	Silent	SNP	C	C	T			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr10:43651086C>T	uc001jan.3	+	1	824	c.489C>T	c.(487-489)ctC>ctT	p.L163L	CSGALNACT2_uc001jam.1_Silent_p.L163L	NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	Homo sapiens chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2), mRNA.	163					chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding	p.G162C(1)		endometrium(12)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						AAATGGGTCTCACTCGCCATC	0.413000													14	65					0	0	1	0	0
STAR	6770	broad.mit.edu	37	8	38005733	38005733	+	Silent	SNP	C	C	T			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr8:38005733C>T	uc003xkv.1	-	2	555	c.291G>A	c.(289-291)aaG>aaA	p.K97K		NM_000349	NP_000340	P49675	STAR_HUMAN	Homo sapiens steroidogenic acute regulatory protein (STAR), nuclear gene encoding mitochondrial protein, mRNA.	97	START.				C21-steroid hormone biosynthetic process	mitochondrial intermembrane space	cholesterol transporter activity			breast(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	11	Colorectal(12;0.000442)	all_lung(54;0.0151)|Lung NSC(58;0.0295)		READ - Rectum adenocarcinoma(644;0.188)		GACTCTCCTTCTTCCAGCCCT	0.557000													9	33					0	0	1	0	0
MB21D1	115004	broad.mit.edu	37	6	74161389	74161389	+	Silent	SNP	C	C	T			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr6:74161389C>T	uc003pgx.1	-	0	655	c.516G>A	c.(514-516)ttG>ttA	p.L172L		NM_138441	NP_612450	Q8N884	M21D1_HUMAN	Homo sapiens Mab-21 domain containing 1 (MB21D1), mRNA.	172										central_nervous_system(1)|large_intestine(4)|lung(1)	6						GGCTGAGCTTCAACTTCTCCA	0.667000													5	26					0	0	1	0	0
NIPAL3	57185	broad.mit.edu	37	1	24785395	24785395	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr1:24785395C>T	uc001bjh.3	+	8	1198	c.791C>T	c.(790-792)tCa>tTa	p.S264L	NIPAL3_uc009vrc.3_Missense_Mutation_p.S182L|NIPAL3_uc001bji.3_Silent_p.L72L	NM_020448	NP_065181	Q6P499	NPAL3_HUMAN	Homo sapiens NIPA-like domain containing 3 (NIPAL3), mRNA.	264						integral to membrane				endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(1)	14						AGTCAAGCCTCACAGATGTAC	0.468000													17	58					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31741165	31741165	+	Silent	SNP	C	C	T			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr6:31741165C>T	uc011dog.2	-	5	1009	c.771G>A	c.(769-771)ccG>ccA	p.P257P	VWA7_uc003nxd.2_Intron|VWA7_uc011doh.1_Intron	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	Homo sapiens von Willebrand factor A domain containing 7 (VWA7), mRNA.	257						extracellular region											TGCCTCCCCTCGGTGGCTGGG	0.602000													5	20					0	0	1	0	0
BFSP2	8419	broad.mit.edu	37	3	133185795	133185795	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr3:133185795C>T	uc003epn.1	+	4	1153	c.1015C>T	c.(1015-1017)Cgt>Tgt	p.R339C		NM_003571	NP_003562	Q13515	BFSP2_HUMAN	Homo sapiens beaded filament structural protein 2, phakinin (BFSP2), mRNA.	339	Rod.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|urinary_tract(1)	13						AGAATCCTTACGTGCCCTGGT	0.517000													16	54					0	0	1	0	0
OR4D9	390199	broad.mit.edu	37	11	59283197	59283197	+	Missense_Mutation	SNP	T	T	A			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr11:59283197T>A	uc010rkv.2	+	0	812	c.812T>A	c.(811-813)aTc>aAc	p.I271N		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily D, member 9 (OR4D9), mRNA.	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						GACACTGCCATCTCTGTCACC	0.532000													45	207					0	0	1	0	0
MAP4K4	9448	broad.mit.edu	37	2	102450904	102450904	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr2:102450904G>C	uc002tbc.3	+	7	1051	c.673G>C	c.(673-675)Gag>Cag	p.E225Q	MAP4K4_uc002tbf.3_Missense_Mutation_p.E225Q|MAP4K4_uc002tbd.3_Missense_Mutation_p.E225Q|MAP4K4_uc010yvy.2_Missense_Mutation_p.E225Q|MAP4K4_uc002tbh.3_Missense_Mutation_p.E225Q|MAP4K4_uc002tbg.3_Missense_Mutation_p.E225Q|MAP4K4_uc002tbi.3_Intron|MAP4K4_uc010yvz.2_Missense_Mutation_p.E205Q|MAP4K4_uc010fiw.1_Missense_Mutation_p.E67Q|MAP4K4_uc002tbj.1_Missense_Mutation_p.E121Q	NM_145687	NP_001229488	O95819	M4K4_HUMAN	Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), transcript variant 3, mRNA.	225	Protein kinase.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TACAGCCATTGAGATGGCAGA	0.408000													4	21					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189060832	189060832	+	Silent	SNP	C	C	T			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr4:189060832C>T	uc003izm.1	+	0	235	c.120C>T	c.(118-120)ctC>ctT	p.L40L		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	Homo sapiens tripartite motif family-like 1 (TRIML1), mRNA.	40					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		TGGTGTGTCTCCTCAGGAGCT	0.547000													67	234					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117900212	117900212	+	Silent	SNP	G	G	A			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr6:117900212G>A	uc003pxu.3	-	1	555	c.301C>T	c.(301-303)Ctg>Ttg	p.L101L	ROS1_uc003pxv.3_Silent_p.L101L|ROS1_uc010keg.2_5'Flank	NM_020399	NP_065132	P08922	ROS_HUMAN	Homo sapiens golgi-associated PDZ and coiled-coil motif containing (GOPC), transcript variant 1, mRNA.	0	Fibronectin type-III 1.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TCAGATTTCAGATCCACCAAC	0.348000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								13	41					0	0	1	0	0
PAN3	255967	broad.mit.edu	37	13	28851441	28851441	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr13:28851441A>G	uc001urz.3	+	14	2269	c.2117A>G	c.(2116-2118)cAg>cGg	p.Q706R	PAN3_uc001ury.3_Missense_Mutation_p.Q394R|PAN3_uc001urx.3_Missense_Mutation_p.Q506R	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	Homo sapiens PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) (PAN3), mRNA.	706	Interaction with PAN2.|Protein kinase.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		GCAGGAATTCAGCGAGAGAAT	0.338000													3	109					0	0	1	0	0
NUBP1	4682	broad.mit.edu	37	16	10855244	10855244	+	Silent	SNP	G	G	C			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr16:10855244G>C	uc002daa.1	+	7	653	c.630G>C	c.(628-630)cgG>cgC	p.R210R	FAM18A_uc010uyr.1_Non-coding_Transcript|FAM18A_uc010uys.1_Non-coding_Transcript|FAM18A_uc010uyt.1_Non-coding_Transcript|FAM18A_uc010bun.2_Non-coding_Transcript|FAM18A_uc010uyu.1_Non-coding_Transcript|FAM18A_uc002dad.3_Non-coding_Transcript|NUBP1_uc010bum.1_Silent_p.R75R|NUBP1_uc002dab.1_Silent_p.R199R	NM_002484	NP_002475	P53384	NUBP1_HUMAN	Homo sapiens nucleotide binding protein 1 (NUBP1), mRNA.	210					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			large_intestine(2)|lung(3)|ovary(1)|skin(4)	10						AGGATGTCCGGAAAGAAATCA	0.537000													19	47					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44839336	44839336	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A28Z-01A-11D-A16O-08	TCGA-BJ-A28Z-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbeaafa1-9d03-47c5-a48a-38fda6ed7840	d8cee918-54f1-448a-8a91-c78d9b645ae3	g.chr3:44839336G>A	uc003cnx.4	+	9	1135	c.986G>A	c.(985-987)gGa>gAa	p.G329E	KIF15_uc010hiq.3_Missense_Mutation_p.G232E|KIF15_uc003cny.1_5'Flank	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	Homo sapiens kinesin family member 15 (KIF15), mRNA.	329					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		GATTCCCTTGGAGGTAATGCC	0.403000													27	74					0	0	1	0	0