Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TG	7038	broad.mit.edu	37	8	133906022	133906022	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A2OL-01A-11D-A18F-08	TCGA-DE-A2OL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc812906-d3b6-4210-a842-96f095280cbf	385b3242-e4b2-4574-9289-48b8826ae644	g.chr8:133906022G>A	uc003ytw.3	+	10	2890	c.2849G>A	c.(2848-2850)cGg>cAg	p.R950Q		NM_003235	NP_003226	P01266	THYG_HUMAN	Homo sapiens thyroglobulin (TG), mRNA.	950	Thyroglobulin type-1 8.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AACAGTTCTCGGTTCCCTCTG	0.572000													4	111					0	0	1	0	0
FOXM1	2305	broad.mit.edu	37	12	2983216	2983216	+	Silent	SNP	T	T	G			TCGA-DE-A2OL-01A-11D-A18F-08	TCGA-DE-A2OL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc812906-d3b6-4210-a842-96f095280cbf	385b3242-e4b2-4574-9289-48b8826ae644	g.chr12:2983216T>G	uc001qle.3	-	1	712	c.429A>C	c.(427-429)ccA>ccC	p.P143P	FOXM1_uc001qlf.3_Silent_p.P143P|FOXM1_uc009zea.3_Silent_p.P143P|FOXM1_uc009zeb.3_Silent_p.P143P|FOXM1_uc001qlg.3_Silent_p.P143P	NM_202002	NP_973731	Q08050	FOXM1_HUMAN	Homo sapiens forkhead box M1 (FOXM1), transcript variant 1, mRNA.	143					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of Ras protein signal transduction|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			CTGCAGGTTTTGGTCCCAAGG	0.572000													3	134					0	0	1	0	0
THPO	7066	broad.mit.edu	37	3	184090683	184090683	+	Missense_Mutation	SNP	G	G	C			TCGA-DE-A2OL-01A-11D-A18F-08	TCGA-DE-A2OL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc812906-d3b6-4210-a842-96f095280cbf	385b3242-e4b2-4574-9289-48b8826ae644	g.chr3:184090683G>C	uc003fol.1	-	5	895	c.680C>G	c.(679-681)gCc>gGc	p.A227G	THPO_uc003fom.2_Missense_Mutation_p.A223G|THPO_uc021xii.1_Missense_Mutation_p.S221R|THPO_uc003fon.3_Missense_Mutation_p.S188R|THPO_uc011bro.2_Missense_Mutation_p.S184R|THPO_uc003fop.3_Missense_Mutation_p.S184R|THPO_uc011brp.2_Intron|THPO_uc011brq.2_Intron|THPO_uc003for.1_Non-coding_Transcript|THPO_uc003fos.1_Non-coding_Transcript	NM_000460	NP_000451	P40225	TPO_HUMAN	Homo sapiens thrombopoietin (THPO), transcript variant 1, mRNA.	227					cell proliferation|platelet activation	extracellular space	cytokine activity|growth factor activity|hormone activity			NS(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGGAATCTTGGCTCTGAATCC	0.527000													4	50					0	0	1	0	0
UBASH3A	53347	broad.mit.edu	37	21	43838718	43838718	+	Splice_Site	SNP	G	G	T			TCGA-DE-A2OL-01A-11D-A18F-08	TCGA-DE-A2OL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc812906-d3b6-4210-a842-96f095280cbf	385b3242-e4b2-4574-9289-48b8826ae644	g.chr21:43838718G>T	uc002zbe.3	+	7	1130	c.1046_splice	c.e7+1	p.R349_splice	UBASH3A_uc002zbf.3_Splice_Site_p.R311_splice|UBASH3A_uc010gpe.3_Splice_Site_p.R311_splice|UBASH3A_uc010gpc.3_Splice_Site|UBASH3A_uc010gpd.3_Splice_Site|U6_uc021wjq.1_5'Flank	NM_018961	NP_061834	P57075	UBS3A_HUMAN	Homo sapiens ubiquitin associated and SH3 domain containing A (UBASH3A), transcript variant 1, mRNA.	349						cytosol|nucleus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(9)|lung(12)|ovary(3)	28						GTGAAGCACAGGTGAGTGCTG	0.582000													13	17					0	0	1	0	0
PDPN	10630	broad.mit.edu	37	1	13942398	13942398	+	Splice_Site	SNP	A	A	G			TCGA-DE-A2OL-01A-11D-A18F-08	TCGA-DE-A2OL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc812906-d3b6-4210-a842-96f095280cbf	385b3242-e4b2-4574-9289-48b8826ae644	g.chr1:13942398A>G	uc001avd.3	+	6	760	c.711_splice	c.e6-2	p.S237_splice	PDPN_uc001avc.3_Splice_Site_p.R235_splice|PDPN_uc009vob.3_Splice_Site_p.S119_splice|PDPN_uc009voc.3_Splice_Site_p.S119_splice|PDPN_uc001ave.3_Splice_Site_p.R117_splice|PDPN_uc001avf.3_Splice_Site_p.S119_splice	NM_006474	NP_001006625	Q86YL7	PDPN_HUMAN	Homo sapiens podoplanin (PDPN), transcript variant 1, mRNA.	161					cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		CTATTTTCACAGGCCCTAAAG	0.478000													3	83					0	0	1	0	0
STK32B	55351	broad.mit.edu	37	4	5468544	5468544	+	Missense_Mutation	SNP	A	A	C			TCGA-DE-A2OL-01A-11D-A18F-08	TCGA-DE-A2OL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc812906-d3b6-4210-a842-96f095280cbf	385b3242-e4b2-4574-9289-48b8826ae644	g.chr4:5468544A>C	uc003gih.1	+	9	1088	c.1024A>C	c.(1024-1026)Aag>Cag	p.K342Q	STK32B_uc010ida.1_Missense_Mutation_p.K295Q	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	Homo sapiens serine/threonine kinase 32B (STK32B), mRNA.	342			K -> T (in dbSNP:rs55961955).				ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	39						GGATGGCACAAAGGACAGCTG	0.502000													3	40					0	0	1	0	0
RGL2	5863	broad.mit.edu	37	6	33263171	33263171	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A2OL-01A-11D-A18F-08	TCGA-DE-A2OL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc812906-d3b6-4210-a842-96f095280cbf	385b3242-e4b2-4574-9289-48b8826ae644	g.chr6:33263171G>A	uc003odv.3	-	7	1609	c.1049C>T	c.(1048-1050)tCa>tTa	p.S350L	RGL2_uc003odu.3_5'UTR|RGL2_uc010jur.3_5'UTR|RGL2_uc003odw.3_Missense_Mutation_p.S268L|RGL2_uc011drb.2_Missense_Mutation_p.S268L	NM_004761	NP_001230667	O15211	RGL2_HUMAN	Homo sapiens ral guanine nucleotide dissociation stimulator-like 2 (RGL2), transcript variant 1, mRNA.	350	Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			breast(2)|cervix(2)|endometrium(7)|kidney(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	34						GGCATAAACTGAAGAGAAGTT	0.602000													5	6					0	0	1	0	0
MAS1L	116511	broad.mit.edu	37	6	29454710	29454710	+	Missense_Mutation	SNP	T	T	C			TCGA-DE-A2OL-01A-11D-A18F-08	TCGA-DE-A2OL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc812906-d3b6-4210-a842-96f095280cbf	385b3242-e4b2-4574-9289-48b8826ae644	g.chr6:29454710T>C	uc011dlq.2	-	0	970	c.970A>G	c.(970-972)Agg>Ggg	p.R324G		NM_052967	NP_443199	P35410	MAS1L_HUMAN	Homo sapiens MAS1 oncogene-like (MAS1L), mRNA.	324						cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity	p.R324G(2)		NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(7)|pancreas(1)|prostate(2)|skin(2)	28						TCCTTCAGCCTTTTCTTTCTG	0.463000													3	127					0	0	1	0	0
OTUB1	55611	broad.mit.edu	37	11	63764532	63764532	+	Missense_Mutation	SNP	T	T	C			TCGA-DE-A2OL-01A-11D-A18F-08	TCGA-DE-A2OL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc812906-d3b6-4210-a842-96f095280cbf	385b3242-e4b2-4574-9289-48b8826ae644	g.chr11:63764532T>C	uc001nyg.1	+	4	1246	c.563T>C	c.(562-564)cTg>cCg	p.L188P	OTUB1_uc001nyf.1_Missense_Mutation_p.L145P|OTUB1_uc010rna.1_Missense_Mutation_p.L154P|OTUB1_uc009ypb.1_Missense_Mutation_p.L115P			Q96FW1	OTUB1_HUMAN	Homo sapiens OTU domain, ubiquitin aldehyde binding 1 (OTUB1), transcript variant 2, non-coding RNA.	145	OTU.				protein K48-linked deubiquitination	cytoplasm	NEDD8-specific protease activity|omega peptidase activity|ubiquitin binding|ubiquitin-specific protease activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	6						TTCATGGACCTGATTGAGCAG	0.617000													3	84					0	0	1	0	0
TEAD4	7004	broad.mit.edu	37	12	3127744	3127744	+	Missense_Mutation	SNP	A	A	T			TCGA-DE-A2OL-01A-11D-A18F-08	TCGA-DE-A2OL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc812906-d3b6-4210-a842-96f095280cbf	385b3242-e4b2-4574-9289-48b8826ae644	g.chr12:3127744A>T	uc010sej.2	+	6	809	c.517A>T	c.(517-519)Acg>Tcg	p.T173S	TEAD4_uc010sek.2_Missense_Mutation_p.T130S|TEAD4_uc001qln.3_Missense_Mutation_p.T44S	NM_201443	NP_958851	Q15561	TEAD4_HUMAN	Homo sapiens TEA domain family member 4 (TEAD4), transcript variant 3, mRNA.	173					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			CCAAGCCGGAACGTCCCATGA	0.582000													18	45					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475419	120475419	+	Missense_Mutation	SNP	T	T	C			TCGA-DE-A2OL-01A-11D-A18F-08	TCGA-DE-A2OL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc812906-d3b6-4210-a842-96f095280cbf	385b3242-e4b2-4574-9289-48b8826ae644	g.chr9:120475419T>C	uc004bjz.3	+	2	1304	c.1013T>C	c.(1012-1014)gTt>gCt	p.V338A	TLR4_uc004bkb.3_Missense_Mutation_p.V138A|TLR4_uc004bka.3_Missense_Mutation_p.V298A	NM_138554	NP_612564	O00206	TLR4_HUMAN	Homo sapiens toll-like receptor 4 (TLR4), transcript variant 1, mRNA.	338					I-kappaB phosphorylation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|T-helper 1 type immune response|Toll signaling pathway|activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|innate immune response|intestinal epithelial structure maintenance|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TTAGAATTAGTTAACTGTAAA	0.338000													14	60					0	0	1	0	0
TUBB4B	10383	broad.mit.edu	37	9	140137041	140137041	+	Missense_Mutation	SNP	C	C	G			TCGA-DE-A2OL-01A-11D-A18F-08	TCGA-DE-A2OL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc812906-d3b6-4210-a842-96f095280cbf	385b3242-e4b2-4574-9289-48b8826ae644	g.chr9:140137041C>G	uc004cmh.1	+	3	473	c.371C>G	c.(370-372)gCt>gGt	p.A124G	TUBB4B_uc004cmg.1_5'UTR	NM_006088	NP_006079	P68371	TBB2C_HUMAN	Homo sapiens tubulin, beta 4B class IVb (TUBB4B), mRNA.	124					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|cellular component movement|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding										AGAAAGGAGGCTGAGAGCTGT	0.617000													26	46					0	0	1	0	0
DOK6	220164	broad.mit.edu	37	18	67231729	67231729	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DE-A2OL-01A-11D-A18F-08	TCGA-DE-A2OL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc812906-d3b6-4210-a842-96f095280cbf	385b3242-e4b2-4574-9289-48b8826ae644	g.chr18:67231729delA	uc002lkl.3	+	1	270	c.73delA	c.(73-75)agafs	p.R25fs		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	Homo sapiens docking protein 6 (DOK6), mRNA.	25	PH.						insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				TCAGATTTTCAGACGATGCTG	0.328													18	23	---	---	---	---