Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TBX20	57057	broad.mit.edu	37	7	35280519	35280519	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A13M-01A-11D-A10S-08	TCGA-DJ-A13M-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f90e2ec-b98e-463d-bf42-c4ec3ad0dc12	f91253d1-45d5-43b4-8cc7-de0ffa145b46	g.chr7:35280519G>A	uc011kas.2	-	4	1265	c.785C>T	c.(784-786)aCg>aTg	p.T262M		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	Homo sapiens T-box 20 (TBX20), transcript variant 1, mRNA.	262						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						AGTGACTGCCGTAAAAACTGT	0.403000													28	42					0	0	1	0	0
ZNHIT1	10467	broad.mit.edu	37	7	100865924	100865924	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A13M-01A-11D-A10S-08	TCGA-DJ-A13M-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f90e2ec-b98e-463d-bf42-c4ec3ad0dc12	f91253d1-45d5-43b4-8cc7-de0ffa145b46	g.chr7:100865924G>A	uc003uye.3	+	1	554	c.62G>A	c.(61-63)cGg>cAg	p.R21Q	ZNHIT1_uc003uyf.3_Non-coding_Transcript	NM_006349	NP_006340	O43257	ZNHI1_HUMAN	Homo sapiens zinc finger, HIT-type containing 1 (ZNHIT1), mRNA.	21							metal ion binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(2)	11	Lung NSC(181;0.168)|all_lung(186;0.215)					GTGCTGGACCGGGCTGCCCGG	0.667000													3	97					0	0	1	0	0
AGAP1	116987	broad.mit.edu	37	2	236957789	236957789	+	Silent	SNP	C	C	A			TCGA-DJ-A13M-01A-11D-A10S-08	TCGA-DJ-A13M-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f90e2ec-b98e-463d-bf42-c4ec3ad0dc12	f91253d1-45d5-43b4-8cc7-de0ffa145b46	g.chr2:236957789C>A	uc002vvs.3	+	15	2576	c.1978C>A	c.(1978-1980)Cga>Aga	p.R660R	AGAP1_uc002vvt.3_Silent_p.R607R	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 (AGAP1), transcript variant 1, mRNA.	660	Arf-GAP.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						CCACCTTTCCCGAGTCCGATC	0.567000													3	116					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-DJ-A13M-01A-11D-A10S-08	TCGA-DJ-A13M-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f90e2ec-b98e-463d-bf42-c4ec3ad0dc12	f91253d1-45d5-43b4-8cc7-de0ffa145b46	g.chr11:533874T>C	uc001lpv.3	-	2	370	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_uc010qvw.2_Missense_Mutation_p.Q61R|HRAS_uc010qvx.2_Missense_Mutation_p.Q61R|HRAS_uc010qvy.2_Non-coding_Transcript	NM_005343	NP_005334	P01112	RASH_HUMAN	Homo sapiens v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS), transcript variant 1, mRNA.	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		Ras protein signal transduction|activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|synaptic transmission	Golgi membrane|cytosol|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(265)|p.Q61L(230)|p.Q61K(59)|p.Q61H(20)|p.Q61P(6)|p.Q61?(1)|p.Q61Q(1)|p.Q61E(1)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			62	79					0	0	1	0	0
SLC5A2	6524	broad.mit.edu	37	16	31499763	31499763	+	Missense_Mutation	SNP	T	T	G			TCGA-DJ-A13M-01A-11D-A10S-08	TCGA-DJ-A13M-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f90e2ec-b98e-463d-bf42-c4ec3ad0dc12	f91253d1-45d5-43b4-8cc7-de0ffa145b46	g.chr16:31499763T>G	uc002ecf.4	+	8	1100	c.1081T>G	c.(1081-1083)Tgc>Ggc	p.C361G	SLC5A2_uc010car.3_Non-coding_Transcript|C16orf58_uc002ecg.3_Non-coding_Transcript	NM_003041	NP_003032	P31639	SC5A2_HUMAN	Homo sapiens solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2), mRNA.	361					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						GGAGGTGGGCTGCTCCAACAT	0.711000													12	5					0	0	1	0	0
ENGASE	64772	broad.mit.edu	37	17	77073871	77073871	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A13M-01A-11D-A10S-08	TCGA-DJ-A13M-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f90e2ec-b98e-463d-bf42-c4ec3ad0dc12	f91253d1-45d5-43b4-8cc7-de0ffa145b46	g.chr17:77073871G>A	uc002jwv.3	+	2	349	c.341G>A	c.(340-342)cGc>cAc	p.R114H	ENGASE_uc002jwu.1_Missense_Mutation_p.R114H|ENGASE_uc010wtz.1_5'UTR|ENGASE_uc002jww.3_5'Flank	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	Homo sapiens endo-beta-N-acetylglucosaminidase (ENGASE), mRNA.	114						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	p.R114L(2)|p.R114C(1)		breast(2)|endometrium(4)|large_intestine(1)|lung(15)|prostate(2)|skin(1)	25						CTGGCGTGTCGCCAGCCCCCT	0.582000													27	46					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196577366	196577366	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A13M-01A-11D-A10S-08	TCGA-DJ-A13M-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f90e2ec-b98e-463d-bf42-c4ec3ad0dc12	f91253d1-45d5-43b4-8cc7-de0ffa145b46	g.chr1:196577366T>C	uc001gtd.1	-	0	134	c.74A>G	c.(73-75)cAa>cGa	p.Q25R	KCNT2_uc001gte.1_Missense_Mutation_p.Q25R|KCNT2_uc001gtf.1_Missense_Mutation_p.Q25R|KCNT2_uc001gtg.1_Non-coding_Transcript|KCNT2_uc009wyu.3_Missense_Mutation_p.Q25R|KCNT2_uc009wyv.1_Missense_Mutation_p.Q25R	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	Homo sapiens potassium channel, subfamily T, member 2 (KCNT2), mRNA.	25						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TTGCCATCCTTGGTCCCCTAG	0.512000													3	148					0	0	1	0	0
WDR62	284403	broad.mit.edu	37	19	36558892	36558892	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DJ-A13M-01A-11D-A10S-08	TCGA-DJ-A13M-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f90e2ec-b98e-463d-bf42-c4ec3ad0dc12	f91253d1-45d5-43b4-8cc7-de0ffa145b46	g.chr19:36558892G>T	uc002odd.2	+	6	953	c.862G>T	c.(862-864)Gag>Tag	p.E288*	WDR62_uc002odc.2_Nonsense_Mutation_p.E288*|WDR62_uc002odb.2_Nonsense_Mutation_p.E288*	NM_001083961	NP_001077430	O43379	WDR62_HUMAN	Homo sapiens WD repeat domain 62 (WDR62), transcript variant 1, mRNA.	288					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GAGGGTGCTGGAGAAGTGGAT	0.577000													7	39					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110830543	110830543	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A13M-01A-11D-A10S-08	TCGA-DJ-A13M-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f90e2ec-b98e-463d-bf42-c4ec3ad0dc12	f91253d1-45d5-43b4-8cc7-de0ffa145b46	g.chr13:110830543C>T	uc001vqw.4	-	31	2616	c.2494G>A	c.(2494-2496)Gga>Aga	p.G832R		NM_001845	NP_001836	P02462	CO4A1_HUMAN	Homo sapiens collagen, type IV, alpha 1 (COL4A1), mRNA.	832	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCAGGGAATCCGGGGAAACCC	0.517000													6	155					0	0	1	0	0
ANP32C	23520	broad.mit.edu	37	4	165118489	165118489	+	Silent	SNP	G	G	A			TCGA-DJ-A13M-01A-11D-A10S-08	TCGA-DJ-A13M-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f90e2ec-b98e-463d-bf42-c4ec3ad0dc12	f91253d1-45d5-43b4-8cc7-de0ffa145b46	g.chr4:165118489G>A	uc011cjk.2	-	0	375	c.375C>T	c.(373-375)aaC>aaT	p.N125N	MARCH1_uc003iqs.2_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member C (ANP32C), mRNA.	125										NS(2)|breast(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(3)|skin(4)	35	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		CTCCGTAGTCGTTCAGGTTGG	0.458000													66	117					0	0	1	0	0