Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIAA1549	57670	broad.mit.edu	37	7	138579148	138579148	+	Silent	SNP	G	G	A			TCGA-DJ-A2PQ-01A-11D-A18F-08	TCGA-DJ-A2PQ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fa0bb18-d8f2-481e-bba2-0afa565b9cf0	b817f147-c91b-4189-925b-c23951bff31f	g.chr7:138579148G>A	uc011kql.2	-	9	4021	c.3972C>T	c.(3970-3972)tgC>tgT	p.C1324C	KIAA1549_uc011kqi.2_Silent_p.C108C|KIAA1549_uc011kqk.2_Silent_p.C108C|KIAA1549_uc011kqj.2_Silent_p.C1324C	NM_001164665	NP_001158137	Q9HCM3	K1549_HUMAN	Homo sapiens KIAA1549 (KIAA1549), transcript variant 2, mRNA.	1324						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						TGTCTGTGCGGCATAGTTTCC	0.527000			O	BRAF	pilocytic astrocytoma								4	117					0	0	1	0	0
RDH10	157506	broad.mit.edu	37	8	74231385	74231385	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2PQ-01A-11D-A18F-08	TCGA-DJ-A2PQ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fa0bb18-d8f2-481e-bba2-0afa565b9cf0	b817f147-c91b-4189-925b-c23951bff31f	g.chr8:74231385A>G	uc003xzi.3	+	2	1268	c.580A>G	c.(580-582)Aca>Gca	p.T194A	RDH10_uc003xzj.3_Missense_Mutation_p.T29A|AK128216_uc003xzk.1_Intron	NM_172037	NP_742034	Q8IZV5	RDH10_HUMAN	Homo sapiens retinol dehydrogenase 10 (all-trans) (RDH10), mRNA.	194					retinal metabolic process|retinol metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|microsome	NADP-retinol dehydrogenase activity|binding|retinol dehydrogenase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(1)	11	Breast(64;0.0954)		Epithelial(68;0.0105)|all cancers(69;0.0465)|BRCA - Breast invasive adenocarcinoma(89;0.0608)			TCATATTGTGACAGTTGCAAG	0.368000													3	109					0	0	1	0	0
INHBE	83729	broad.mit.edu	37	12	57850257	57850257	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2PQ-01A-11D-A18F-08	TCGA-DJ-A2PQ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fa0bb18-d8f2-481e-bba2-0afa565b9cf0	b817f147-c91b-4189-925b-c23951bff31f	g.chr12:57850257G>A	uc001snw.3	+	1	903	c.679G>A	c.(679-681)Gag>Aag	p.E227K		NM_031479	NP_113667	P58166	INHBE_HUMAN	Homo sapiens inhibin, beta E (INHBE), mRNA.	227					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	15						CCGAGCCAATGAGCCTGGAGC	0.602000											OREG0021944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	124					0	0	1	0	0
ZNF80	7634	broad.mit.edu	37	3	113955140	113955140	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A2PQ-01A-11D-A18F-08	TCGA-DJ-A2PQ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fa0bb18-d8f2-481e-bba2-0afa565b9cf0	b817f147-c91b-4189-925b-c23951bff31f	g.chr3:113955140G>T	uc010hqo.3	-	0	1286	c.782C>A	c.(781-783)gCc>gAc	p.A261D	ZNF80_uc003ebf.3_Non-coding_Transcript	NM_007136	NP_009067	P51504	ZNF80_HUMAN	Homo sapiens zinc finger protein 80 (ZNF80), mRNA.	261						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|urinary_tract(2)	32		Lung NSC(201;0.0233)|all_neural(597;0.0837)				ACTCTGTTGGGCAAAAGCAGA	0.403000													5	92					0	0	1	0	0
FBF1	85302	broad.mit.edu	37	17	73908312	73908312	+	Silent	SNP	G	G	A			TCGA-DJ-A2PQ-01A-11D-A18F-08	TCGA-DJ-A2PQ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fa0bb18-d8f2-481e-bba2-0afa565b9cf0	b817f147-c91b-4189-925b-c23951bff31f	g.chr17:73908312G>A	uc002jqc.3	-	27	3553	c.3279C>T	c.(3277-3279)ctC>ctT	p.L1093L	FBF1_uc002jqa.1_Non-coding_Transcript|FBF1_uc010wsp.2_Silent_p.L1084L|MRPL38_uc002jpz.1_5'Flank|FBF1_uc002jqb.3_Non-coding_Transcript|FBF1_uc010dgr.2_Silent_p.L403L	NM_001080542	NP_001074011	A6NLR5	A6NLR5_HUMAN	Homo sapiens Fas (TNFRSF6) binding factor 1 (FBF1), mRNA.	1093										large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	4						GCCTGGCATGGAGGTGCAAGG	0.632000													7	18					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A2PQ-01A-11D-A18F-08	TCGA-DJ-A2PQ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fa0bb18-d8f2-481e-bba2-0afa565b9cf0	b817f147-c91b-4189-925b-c23951bff31f	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				19	20					0	0	1	0	0
TRAPPC6A	79090	broad.mit.edu	37	19	45668203	45668203	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2PQ-01A-11D-A18F-08	TCGA-DJ-A2PQ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fa0bb18-d8f2-481e-bba2-0afa565b9cf0	b817f147-c91b-4189-925b-c23951bff31f	g.chr19:45668203T>C	uc002pav.3	-	2	229	c.220A>G	c.(220-222)Agg>Ggg	p.R74G	TRAPPC6A_uc002paw.3_Missense_Mutation_p.R60G	NM_024108	NP_077013	O75865	TPC6A_HUMAN	Homo sapiens trafficking protein particle complex 6A (TRAPPC6A), mRNA.	60					vesicle-mediated transport	Golgi apparatus|endoplasmic reticulum	guanylate cyclase activity|heme binding	p.R74M(1)		autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|prostate(2)	8		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00872)|GBM - Glioblastoma multiforme(486;0.233)		AGCTCCTCCCTGAAGGCCAGC	0.637000													3	80					0	0	1	0	0
SNX17	9784	broad.mit.edu	37	2	27599354	27599354	+	Silent	SNP	T	T	C			TCGA-DJ-A2PQ-01A-11D-A18F-08	TCGA-DJ-A2PQ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fa0bb18-d8f2-481e-bba2-0afa565b9cf0	b817f147-c91b-4189-925b-c23951bff31f	g.chr2:27599354T>C	uc002rkg.1	+	13	1488	c.1266T>C	c.(1264-1266)ccT>ccC	p.P422P	SNX17_uc010ylj.1_Silent_p.P402P|SNX17_uc002rki.1_Non-coding_Transcript|SNX17_uc002rkh.1_Silent_p.P208P|SNX17_uc010yll.1_Silent_p.P208P|SNX17_uc010ylm.1_Silent_p.P208P|SNX17_uc010yln.1_Silent_p.P410P|SNX17_uc010ylo.1_Silent_p.P340P|SNX17_uc010ylp.1_Silent_p.P397P|SNX17_uc010ylk.1_Silent_p.P208P|SNX17_uc010eza.1_Silent_p.P208P|SNX17_uc010ylq.1_Silent_p.P208P	NM_014748	NP_055563	Q15036	SNX17_HUMAN	Homo sapiens sorting nexin 17 (SNX17), mRNA.	422					cell communication|endosome transport|intracellular protein transport|regulation of endocytosis|signal transduction	Golgi apparatus|cytoplasmic vesicle membrane|cytosol|early endosome	low-density lipoprotein particle receptor binding|phosphatidylinositol binding|protein C-terminus binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAGTCACCTGATGCCACCC	0.552000													3	100					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052786	15052786	+	Silent	SNP	C	C	A			TCGA-DJ-A2PQ-01A-11D-A18F-08	TCGA-DJ-A2PQ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fa0bb18-d8f2-481e-bba2-0afa565b9cf0	b817f147-c91b-4189-925b-c23951bff31f	g.chr19:15052786C>A	uc010xoc.2	+	0	486	c.486C>A	c.(484-486)acC>acA	p.T162T		NM_012377	NP_036509	O60412	OR7C2_HUMAN	Homo sapiens olfactory receptor, family 7, subfamily C, member 2 (OR7C2), mRNA.	162					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					AGACCTTGACCATTTTGAGGC	0.507000													85	130					0	0	1	0	0
MATR3	9782	broad.mit.edu	37	5	138643991	138643991	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A2PQ-01A-11D-A18F-08	TCGA-DJ-A2PQ-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fa0bb18-d8f2-481e-bba2-0afa565b9cf0	b817f147-c91b-4189-925b-c23951bff31f	g.chr5:138643991G>T	uc003ldw.3	+	2	1290	c.887G>T	c.(886-888)tGt>tTt	p.C296F	MATR3_uc003lds.3_Missense_Mutation_p.C296F|MATR3_uc003ldt.3_Intron|MATR3_uc003ldu.3_Missense_Mutation_p.C296F|MATR3_uc010jfb.3_Missense_Mutation_p.C296F|MATR3_uc003ldx.3_Missense_Mutation_p.C296F|MATR3_uc003ldy.3_Intron|MATR3_uc003ldz.3_Missense_Mutation_p.C296F|MATR3_uc011czb.2_Intron	NM_018834	NP_954659	P43243	MATR3_HUMAN	Homo sapiens matrin 3 (MATR3), transcript variant 2, mRNA.	296						nuclear inner membrane|nuclear matrix	RNA binding|nucleotide binding|protein binding|structural molecule activity|zinc ion binding			breast(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TGCTCTATATGTGATTTGCCA	0.378000													4	106					0	0	1	0	0