Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SETX	23064	broad.mit.edu	37	9	135140069	135140069	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chr9:135140069G>C	uc004cbk.3	-	25	7774	c.7591C>G	c.(7591-7593)Cct>Gct	p.P2531A	SETX_uc004cbj.3_Missense_Mutation_p.P2179A|SETX_uc010mzt.3_Missense_Mutation_p.P2117A	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	Homo sapiens senataxin (SETX), mRNA.	2531					RNA processing|cell death|double-strand break repair	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TCATGAACAGGAGGTCTTTCA	0.488000													3	109					0	0	1	0	0
VCP	7415	broad.mit.edu	37	9	35065309	35065309	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chr9:35065309G>A	uc003zvy.2	-	4	904	c.515C>T	c.(514-516)cCt>cTt	p.P172L	VCP_uc010mkh.1_5'UTR|VCP_uc010mki.1_Missense_Mutation_p.P127L	NM_007126	NP_009057	P55072	TERA_HUMAN	Homo sapiens valosin containing protein (VCP), mRNA.	172					ER-associated protein catabolic process|activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AATGCAATAAGGGCTAGGATC	0.478000													18	40					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115898369	115898369	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chr4:115898369C>T	uc003ibu.3	-	2	1719	c.1040G>A	c.(1039-1041)gGa>gAa	p.G347E	NDST4_uc010imw.3_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	Homo sapiens N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 (NDST4), mRNA.	347	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CCCTGAAAATCCAAGGTTGAA	0.323000													4	100					0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47369997	47369997	+	Silent	SNP	G	G	A			TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chr11:47369997G>A	uc021qis.1	-	5	805	c.750C>T	c.(748-750)tcC>tcT	p.S250S	MYBPC3_uc021qir.1_5'UTR	NM_000256	NP_000247	Q14896	MYPC3_HUMAN	Homo sapiens myosin binding protein C, cardiac (MYBPC3), mRNA.	250	Ig-like C2-type 1.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	ATPase activator activity|actin binding|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		GATTGAAGTTGGAGCAGTCAA	0.577000													7	18					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146480652	146480652	+	Missense_Mutation	SNP	T	T	G			TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chr6:146480652T>G	uc010khw.1	+	2	1339	c.869T>G	c.(868-870)tTc>tGc	p.F290C	GRM1_uc010khu.1_Missense_Mutation_p.F290C|GRM1_uc010khv.1_Missense_Mutation_p.F290C|GRM1_uc003qll.2_Missense_Mutation_p.F290C|GRM1_uc011edz.1_Missense_Mutation_p.F290C|GRM1_uc011eea.1_Missense_Mutation_p.F290C	NM_000838	NP_000829	Q13255	GRM1_HUMAN	Homo sapiens glutamate receptor, metabotropic 1 (GRM1), transcript variant 1, mRNA.	290					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GTGGTCTGCTTCTGTGAAGGC	0.552000													3	86					0	0	1	0	0
ACOT12	134526	broad.mit.edu	37	5	80626733	80626733	+	Missense_Mutation	SNP	G	G	A	rs80124231	by1000genomes	TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chr5:80626733G>A	uc003khl.4	-	13	1473	c.1418C>T	c.(1417-1419)tCg>tTg	p.S473L	RNU5E-1_uc011cto.1_Intron	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	Homo sapiens acyl-CoA thioesterase 12 (ACOT12), mRNA.	473	START.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)	23		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		CAAAATGACCGACTTCACTGC	0.398000													15	17					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3828107	3828107	+	Nonsense_Mutation	SNP	A	A	T			TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chr16:3828107A>T	uc002cvv.3	-	9	2222	c.2018T>A	c.(2017-2019)tTa>tAa	p.L673*	CREBBP_uc002cvw.3_Nonsense_Mutation_p.L635*	NM_004380	NP_004371	Q92793	CBP_HUMAN	Homo sapiens CREB binding protein (CREBBP), transcript variant 1, mRNA.	673					N-terminal peptidyl-lysine acetylation|cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	MyoD binding|histone acetyltransferase activity|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.R672C(1)		NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TTGTTTATGTAAACGCGACCT	0.433000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						7	152					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84495624	84495624	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chr16:84495624A>G	uc010chj.3	+	26	2787	c.2698A>G	c.(2698-2700)Agg>Ggg	p.R900G	ATP2C2_uc002fhx.3_Missense_Mutation_p.R871G|ATP2C2_uc002fhy.3_Missense_Mutation_p.R888G|ATP2C2_uc002fhz.3_Missense_Mutation_p.R720G|ATP2C2_uc002fia.3_Missense_Mutation_p.R182G	NM_014861	NP_055676	O75185	AT2C2_HUMAN	Homo sapiens ATPase, Ca++ transporting, type 2C, member 2 (ATP2C2), mRNA.	871					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						CGGCTTTCTCAGGAACCACAT	0.587000													3	132					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158623172	158623172	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chr1:158623172G>A	uc001fst.1	-	21	3279	c.3080C>T	c.(3079-3081)cCa>cTa	p.P1027L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	Homo sapiens spectrin, alpha, erythrocytic 1 (elliptocytosis 2) (SPTA1), mRNA.	1027	SH3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					ATAGACAGCTGGGACAATGCC	0.552000													6	76					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873707	91873707	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chrX:91873707A>G	uc004efk.2	+	6	4657	c.3812A>G	c.(3811-3813)cAg>cGg	p.Q1271R	PCDH11X_uc004efl.2_Missense_Mutation_p.Q1261R|PCDH11X_uc010nmv.2_3'UTR|PCDH11X_uc004efm.2_Missense_Mutation_p.Q1263R|PCDH11X_uc004efn.2_Missense_Mutation_p.Q1253R|PCDH11X_uc004efo.2_Missense_Mutation_p.Q1234R	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	Homo sapiens protocadherin 11 X-linked (PCDH11X), transcript variant c, mRNA.	1271					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CATCGTAGTCAGGCCCAATCA	0.547000													4	258					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	124079864	124079864	+	Silent	SNP	T	T	C			TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chr5:124079864T>C	uc003ktq.1	-	0	1002	c.819A>G	c.(817-819)tcA>tcG	p.S273S	ZNF608_uc003ktr.1_Non-coding_Transcript|ZNF608_uc003kts.1_Silent_p.S273S|ZNF608_uc003ktt.1_Silent_p.S273S	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	Homo sapiens zinc finger protein 608 (ZNF608), mRNA.	273						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CCATGAGCCCTGAATCCGGGG	0.562000													4	212					0	0	1	0	0
PIGZ	80235	broad.mit.edu	37	3	196675177	196675177	+	Silent	SNP	C	C	G			TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chr3:196675177C>G	uc003fxh.3	-	2	738	c.591G>C	c.(589-591)acG>acC	p.T197T		NM_025163	NP_079439	Q86VD9	PIGZ_HUMAN	Homo sapiens phosphatidylinositol glycan anchor biosynthesis, class Z (PIGZ), mRNA.	197					GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			breast(1)|endometrium(1)|lung(7)|ovary(3)|prostate(1)|urinary_tract(1)	14	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		TAGGGCCCCACGTTACATGGG	0.607000													3	63					0	0	1	0	0
PRR22	163154	broad.mit.edu	37	19	5783841	5783841	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chr19:5783841delC	uc010xiv.1	-	2	522	c.417delG	c.(415-417)gggfs	p.G139fs	PRR22_uc002mdb.1_Frame_Shift_Del_p.G137fs	NM_001134316	NP_001127788	Q8IZ63	PRR22_HUMAN	Homo sapiens proline rich 22 (PRR22), mRNA.	137	Pro-rich.									endometrium(2)|large_intestine(1)|prostate(1)|urinary_tract(1)	5						GAAACTGGGGCCCCCCGGGTG	0.721													2	4	---	---	---	---					
ADAM33	80332	broad.mit.edu	37	20	3652627	3652627	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DJ-A2Q8-01A-11D-A18F-08	TCGA-DJ-A2Q8-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa837b4d-55a7-4dcf-9fdf-cf9c13644df7	cf88aecb-dc11-4f6f-9072-bc153c7a62d9	g.chr20:3652627delG	uc002wit.3	-	14	1690	c.1603delC	c.(1603-1605)cacfs	p.H535fs	ADAM33_uc002wiq.1_5'Flank|ADAM33_uc002wir.1_Frame_Shift_Del_p.H535fs|ADAM33_uc002wis.3_Frame_Shift_Del_p.H57fs|ADAM33_uc002wiu.3_Frame_Shift_Del_p.H535fs|AX748440_uc002wiv.1_5'Flank|ADAM33_uc002wiw.1_Intron|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	Homo sapiens ADAM metallopeptidase domain 33 (ADAM33), transcript variant 1, mRNA.	535	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|skin(3)	29						GGAGCTGGGTGGGAGCCTGAG	0.652													2	4	---	---	---	---