Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PCDHB9	56127	broad.mit.edu	37	5	140568536	140568536	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A2QB-01A-11D-A19J-08	TCGA-DJ-A2QB-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1584fb00-5b1c-4b75-89d8-e9504b8bc989	5e27ef92-19e3-430a-991b-53b55c88baaf	g.chr5:140568536G>C	uc003liw.1	+	1	1642	c.1642G>C	c.(1642-1644)Gta>Cta	p.V548L		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	Homo sapiens protocadherin beta 9 (PCDHB9), mRNA.	549	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding							KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGGTGCGCGTACTGGTGCT	0.711000													5	54					0	0	1	0	0
LARS	51520	broad.mit.edu	37	5	145524092	145524092	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2QB-01A-11D-A19J-08	TCGA-DJ-A2QB-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1584fb00-5b1c-4b75-89d8-e9504b8bc989	5e27ef92-19e3-430a-991b-53b55c88baaf	g.chr5:145524092T>C	uc003lnx.1	-	16	1836	c.1598A>G	c.(1597-1599)gAt>gGt	p.D533G	LARS_uc011dbq.1_Missense_Mutation_p.D487G|LARS_uc011dbr.1_Missense_Mutation_p.D479G|LARS_uc011dbs.1_Missense_Mutation_p.D506G	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	Homo sapiens leucyl-tRNA synthetase (LARS), mRNA.	533					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	TTCTCCATAATCCAAGTACCT	0.388000													30	56					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7520684	7520684	+	Splice_Site	SNP	T	T	A			TCGA-DJ-A2QB-01A-11D-A19J-08	TCGA-DJ-A2QB-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1584fb00-5b1c-4b75-89d8-e9504b8bc989	5e27ef92-19e3-430a-991b-53b55c88baaf	g.chr12:7520684T>A	uc010sge.2	-	17	4239	c.4213_splice	c.e17+1	p.V1405_splice	CD163L1_uc001qsy.3_Splice_Site_p.V1395_splice	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	Homo sapiens CD163 molecule-like 1 (CD163L1), mRNA.	1395						extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						GGCTCTCACCTCTGAGGGGCA	0.463000													17	45					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-DJ-A2QB-01A-11D-A19J-08	TCGA-DJ-A2QB-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1584fb00-5b1c-4b75-89d8-e9504b8bc989	5e27ef92-19e3-430a-991b-53b55c88baaf	g.chr11:533874T>C	uc001lpv.3	-	2	370	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_uc010qvw.2_Missense_Mutation_p.Q61R|HRAS_uc010qvx.2_Missense_Mutation_p.Q61R|HRAS_uc010qvy.2_Non-coding_Transcript	NM_005343	NP_005334	P01112	RASH_HUMAN	Homo sapiens v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS), transcript variant 1, mRNA.	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		Ras protein signal transduction|activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|synaptic transmission	Golgi membrane|cytosol|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(265)|p.Q61L(230)|p.Q61K(59)|p.Q61H(20)|p.Q61P(6)|p.Q61?(1)|p.Q61Q(1)|p.Q61E(1)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			15	42					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50727260	50727260	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A2QB-01A-11D-A19J-08	TCGA-DJ-A2QB-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1584fb00-5b1c-4b75-89d8-e9504b8bc989	5e27ef92-19e3-430a-991b-53b55c88baaf	g.chr22:50727260G>C	uc003bkv.4	-	4	1385	c.1292C>G	c.(1291-1293)tCt>tGt	p.S431C		NM_012401	NP_036533	O15031	PLXB2_HUMAN	Homo sapiens plexin B2 (PLXNB2), mRNA.	431	Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CACAAGGATAGAGTCGTACTC	0.612000													4	7					0	0	1	0	0
DSTYK	25778	broad.mit.edu	37	1	205128809	205128809	+	Splice_Site	SNP	T	T	G			TCGA-DJ-A2QB-01A-11D-A19J-08	TCGA-DJ-A2QB-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1584fb00-5b1c-4b75-89d8-e9504b8bc989	5e27ef92-19e3-430a-991b-53b55c88baaf	g.chr1:205128809T>G	uc001hbw.3	-	9	2170	c.2106_splice	c.e9-1	p.R702_splice	DSTYK_uc001hbx.3_Splice_Site_p.R702_splice	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	Homo sapiens dual serine/threonine and tyrosine protein kinase (DSTYK), transcript variant 1, mRNA.	702	Protein kinase.					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						GGCAGAGACCTGGAGGGAAGG	0.498000													8	22					0	0	1	0	0
CDKN2C	1031	broad.mit.edu	37	1	51439634	51439634	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2QB-01A-11D-A19J-08	TCGA-DJ-A2QB-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1584fb00-5b1c-4b75-89d8-e9504b8bc989	5e27ef92-19e3-430a-991b-53b55c88baaf	g.chr1:51439634G>A	uc001csf.3	+	2	2174	c.199G>A	c.(199-201)Gac>Aac	p.D67N	CDKN2C_uc001csg.3_Missense_Mutation_p.D67N	NM_001262	NP_523240	P42773	CDN2C_HUMAN	Homo sapiens cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) (CDKN2C), transcript variant 1, mRNA.	67					G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|cell cycle arrest|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding	p.0?(11)|p.?(1)		central_nervous_system(8)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|thyroid(1)	23				GBM - Glioblastoma multiforme(3;3.61e-13)|all cancers(3;0.00151)		CGATTTGAAAGACCGAACTGG	0.448000			D		"""glioma, MM"""								30	50					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142606711	142606711	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2QB-01A-11D-A19J-08	TCGA-DJ-A2QB-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1584fb00-5b1c-4b75-89d8-e9504b8bc989	5e27ef92-19e3-430a-991b-53b55c88baaf	g.chr7:142606711G>A	uc003wby.1	-	13	2104	c.1840C>T	c.(1840-1842)Cct>Tct	p.P614S		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	Homo sapiens transient receptor potential cation channel, subfamily V, member 5 (TRPV5), mRNA.	614					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CCGGAGCGAGGCCACAGGCAG	0.592000													10	30					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45399037	45399037	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DJ-A2QB-01A-11D-A19J-08	TCGA-DJ-A2QB-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1584fb00-5b1c-4b75-89d8-e9504b8bc989	5e27ef92-19e3-430a-991b-53b55c88baaf	g.chr15:45399037delA	uc001zun.3	-	14	2027	c.1824delT	c.(1822-1824)cttfs	p.L608fs	DUOX2_uc010bea.3_Frame_Shift_Del_p.L608fs	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	Homo sapiens dual oxidase 2 (DUOX2), mRNA.	608					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	NAD(P)H oxidase activity|calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CACCTAAGGGAAGGCAGCAGA	0.582													2	4	---	---	---	---