Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
VWA3B	200403	broad.mit.edu	37	2	98750306	98750306	+	Missense_Mutation	SNP	A	A	G			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr2:98750306A>G	uc002syo.3	+	6	1156	c.892A>G	c.(892-894)Aga>Gga	p.R298G	VWA3B_uc010yvh.2_Missense_Mutation_p.R148G|VWA3B_uc002syj.3_Non-coding_Transcript|VWA3B_uc002syk.1_Non-coding_Transcript|VWA3B_uc002syl.1_Intron|VWA3B_uc002sym.3_Missense_Mutation_p.R298G|VWA3B_uc002syn.1_Non-coding_Transcript	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	Homo sapiens von Willebrand factor A domain containing 3B (VWA3B), mRNA.	298										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						ATTTGCCGAGAGAACAGAGTG	0.473000													5	323					0	0	1	0	0
AGL	178	broad.mit.edu	37	1	100366293	100366293	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr1:100366293G>A	uc001dsi.1	+	25	3864	c.3464G>A	c.(3463-3465)tGg>tAg	p.W1155*	AGL_uc001dsj.1_Nonsense_Mutation_p.W1155*|AGL_uc001dsk.1_Nonsense_Mutation_p.W1155*|AGL_uc001dsl.1_Nonsense_Mutation_p.W1155*|AGL_uc001dsm.1_Nonsense_Mutation_p.W1139*|AGL_uc001dsn.1_Nonsense_Mutation_p.W1138*	NM_000642	NP_000635	P35573	GDE_HUMAN	Homo sapiens amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase (AGL), transcript variant 1, mRNA.	1155					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		GATGCTGTGTGGTGGTGGCTG	0.428000													5	329					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87031478	87031478	+	Missense_Mutation	SNP	C	C	G			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr7:87031478C>G	uc003uiv.1	-	27	3871	c.3795G>C	c.(3793-3795)caG>caC	p.Q1265H	ABCB4_uc003uiw.1_Missense_Mutation_p.Q1258H|ABCB4_uc003uix.1_Missense_Mutation_p.Q1211H	NM_018849	NP_061337	P21439	MDR3_HUMAN	Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 4 (ABCB4), transcript variant B, mRNA.	1265	ABC transporter 2.				cellular lipid metabolic process	Golgi membrane|apical plasma membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GTGCCAGCAGCTGCTGATGCG	0.443000													5	185					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	823129	823129	+	Splice_Site	SNP	C	C	G			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr16:823129C>G	uc002cjz.1	-	10	2139	c.2139_splice	c.e10+1	p.Q713_splice		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	Homo sapiens mesothelin-like (MSLNL), mRNA.	362					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						AGCCGTGCACCTGTGCGAGCT	0.657000													6	102					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	4020293	4020293	+	Missense_Mutation	SNP	G	G	C			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr17:4020293G>C	uc002fxe.3	-	2	731	c.667C>G	c.(667-669)Ctg>Gtg	p.L223V	ZZEF1_uc002fxk.1_Missense_Mutation_p.L223V	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	Homo sapiens zinc finger, ZZ-type with EF-hand domain 1 (ZZEF1), mRNA.	223							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						AGCTGATCCAGAGACTCCTTC	0.512000													17	322					0	0	1	0	0
S100A7	6278	broad.mit.edu	37	1	153430314	153430314	+	Missense_Mutation	SNP	C	C	G			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr1:153430314C>G	uc001fbv.1	-	2	345	c.274G>C	c.(274-276)Gga>Cga	p.G92R		NM_002963	NP_002954	P31151	S10A7_HUMAN	Homo sapiens S100 calcium binding protein A7 (S100A7), mRNA.	92					angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of T cell chemotaxis|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	RAGE receptor binding|calcium ion binding|zinc ion binding			breast(1)|large_intestine(2)|lung(5)|skin(2)	10	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGCGCTGCTCCATGGCTCTGC	0.517000													4	121					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5727298	5727298	+	Missense_Mutation	SNP	C	C	A			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr19:5727298C>A	uc002mda.3	+	2	207	c.146C>A	c.(145-147)cCt>cAt	p.P49H	CATSPERD_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	Homo sapiens transmembrane protein 146 (TMEM146), mRNA.	49						integral to membrane											TATTTTCATCCTACAACAACA	0.303000													3	93					0	0	1	0	0
NCAPD3	23310	broad.mit.edu	37	11	134029936	134029936	+	Missense_Mutation	SNP	C	C	G			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr11:134029936C>G	uc001qhd.1	-	28	4324	c.3718G>C	c.(3718-3720)Gac>Cac	p.D1240H	NCAPD3_uc010scm.1_Non-coding_Transcript|NCAPD3_uc009zda.1_Non-coding_Transcript	NM_015261	NP_056076	P42695	CNDD3_HUMAN	Homo sapiens non-SMC condensin II complex, subunit D3 (NCAPD3), mRNA.	1240					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		GCAAAGAAGTCCTTGAGCTCA	0.473000													6	98					0	0	1	0	0
GPR142	350383	broad.mit.edu	37	17	72366698	72366698	+	Missense_Mutation	SNP	G	G	A			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr17:72366698G>A	uc021ucp.1	+	2	397	c.388G>A	c.(388-390)Gtc>Atc	p.V130I	GPR142_uc010wqy.2_Missense_Mutation_p.V133I	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	Homo sapiens G protein-coupled receptor 142 (GPR142), mRNA.	133						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						CACGCCCCACGTCAGCGGGCT	0.617000													6	44					0	0	1	0	0
MCF2	4168	broad.mit.edu	37	X	138668623	138668623	+	Missense_Mutation	SNP	C	C	T			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chrX:138668623C>T	uc011mwo.1	-	26	2935	c.2774G>A	c.(2773-2775)aGt>aAt	p.S925N	MCF2_uc004fav.3_Missense_Mutation_p.S865N|MCF2_uc004fau.3_Missense_Mutation_p.S849N|MCF2_uc010nsh.2_Intron|MCF2_uc011mwm.2_Intron|MCF2_uc011mwl.2_Missense_Mutation_p.S826N|MCF2_uc011mwn.1_Intron|MCF2_uc004faw.2_Missense_Mutation_p.S909N	NM_001171876	NP_001165347	P10911	MCF2_HUMAN	Homo sapiens MCF.2 cell line derived transforming sequence (MCF2), transcript variant 3, mRNA.	849					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	Rho guanyl-nucleotide exchange factor activity|protein binding			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					TTCCTCAGTACTTATAAAAGC	0.383000													7	92					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43489545	43489545	+	Silent	SNP	G	G	T			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr15:43489545G>T	uc001zrb.4	-	12	2421	c.2121C>A	c.(2119-2121)acC>acA	p.T707T	EPB42_uc001zqz.4_Silent_p.T344T|EPB42_uc001zra.4_Silent_p.T677T|EPB42_uc010udm.2_Silent_p.T599T	NM_000119	NP_000110	P16452	EPB42_HUMAN	Homo sapiens erythrocyte membrane protein band 4.2 (EPB42), transcript variant 1, mRNA.	677					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		TTTTATAGTTGGTTAGGTTCT	0.483000													3	70					0	0	1	0	0
PKP4	8502	broad.mit.edu	37	2	159477861	159477861	+	Silent	SNP	G	G	A			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr2:159477861G>A	uc002tzv.3	+	5	791	c.531G>A	c.(529-531)caG>caA	p.Q177Q	PKP4_uc002tzt.1_Silent_p.Q29Q|PKP4_uc002tzu.3_Silent_p.Q177Q|PKP4_uc002tzw.3_Silent_p.Q177Q|PKP4_uc002tzx.3_5'UTR|PKP4_uc002tzy.1_5'UTR|PKP4_uc002tzz.1_Silent_p.Q175Q|PKP4_uc002uaa.3_Silent_p.Q29Q	NM_003628	NP_003619	Q99569	PKP4_HUMAN	Homo sapiens plakophilin 4 (PKP4), transcript variant 1, mRNA.	177					cell adhesion	desmosome	protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(21)|ovary(6)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	61						ACAGACAGCAGCATTCATTCA	0.453000										HNSCC(62;0.18)			3	100					0	0	1	0	0
INPP5B	3633	broad.mit.edu	37	1	38409493	38409493	+	Silent	SNP	G	G	C			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr1:38409493G>C	uc001ccg.1	-	3	319	c.225C>G	c.(223-225)gtC>gtG	p.V75V	INPP5B_uc009vvk.1_Silent_p.V16V|INPP5B_uc001cch.3_Silent_p.V16V	NM_005540	NP_005531	P32019	I5P2_HUMAN	Homo sapiens inositol polyphosphate-5-phosphatase, 75kDa (INPP5B), nuclear gene encoding mitochondrial protein, mRNA.	75					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(9)|urinary_tract(1)	15	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AATCCCGCGAGACTGGCACTA	0.582000													6	207					0	0	1	0	0
ZMAT1	84460	broad.mit.edu	37	X	101138612	101138612	+	Missense_Mutation	SNP	C	C	T	rs141908807	byFrequency	TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chrX:101138612C>T	uc011mrl.2	-	6	2137	c.1787G>A	c.(1786-1788)cGa>cAa	p.R596Q	ZMAT1_uc004eim.3_Missense_Mutation_p.R425Q|ZMAT1_uc004ein.3_Missense_Mutation_p.R425Q|ZMAT1_uc011mrm.2_Missense_Mutation_p.R425Q	NM_001011657	NP_001011657	A7MD47	A7MD47_HUMAN	Homo sapiens zinc finger, matrin-type 1 (ZMAT1), transcript variant 1, mRNA.	425						nucleus	zinc ion binding	p.R425Q(1)		endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22						TTTCTTTTTTCGATGCTTAAG	0.383000													4	65					0	0	1	0	0
FBXO41	150726	broad.mit.edu	37	2	73486158	73486158	+	Silent	SNP	C	C	T			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr2:73486158C>T	uc021vjh.1	-	11	2670	c.2580G>A	c.(2578-2580)agG>agA	p.R860R		NM_001080410	NP_001073879	Q8TF61	FBX41_HUMAN	Homo sapiens F-box protein 41 (FBXO41), mRNA.	860						intracellular	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)	13						AGAAGCCGGGCCTCCGTCGCA	0.677000													4	7					0	0	1	0	0
MX1	4599	broad.mit.edu	37	21	42812881	42812881	+	Missense_Mutation	SNP	A	A	G			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr21:42812881A>G	uc002yzh.3	+	10	1606	c.659A>G	c.(658-660)aAt>aGt	p.N220S	MX1_uc010goq.3_Missense_Mutation_p.N220S|MX1_uc002yzi.3_Missense_Mutation_p.N220S	NM_001144925	NP_002453	P20591	MX1_HUMAN	Homo sapiens myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (MX1), transcript variant 1, mRNA.	220					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	27		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				GTCCCCAGTAATGTGGACATC	0.572000													14	147					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62414648	62414648	+	Silent	SNP	G	G	A			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr11:62414648G>A	uc001nud.3	-	1	2957	c.2904C>T	c.(2902-2904)cgC>cgT	p.R968R	GANAB_uc001nua.3_5'Flank|GANAB_uc001nub.3_5'Flank|GANAB_uc001nuc.3_5'Flank|GANAB_uc010rma.2_5'Flank|GANAB_uc010rmb.2_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	Homo sapiens integrator complex subunit 5 (INTS5), mRNA.	968					snRNA processing	integral to membrane|integrator complex	protein binding	p.G967S(1)		breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						CCCGAATGAAGCGACCCCGCT	0.597000													5	171					0	0	1	0	0
ZC3H13	23091	broad.mit.edu	37	13	46619560	46619560	+	Missense_Mutation	SNP	T	T	A			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr13:46619560T>A	uc010tfw.1	-	0	89	c.83A>T	c.(82-84)gAg>gTg	p.E28V	ZC3H13_uc001vas.1_Missense_Mutation_p.E28V|ZC3H13_uc001vat.1_Missense_Mutation_p.E28V	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	Homo sapiens zinc finger CCCH-type containing 13 (ZC3H13), mRNA.	28							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCCAAGCCTCTCAAATACACT	0.403000													7	250					0	0	1	0	0
SOWAHC	65124	broad.mit.edu	37	2	110373405	110373405	+	Missense_Mutation	SNP	G	G	T			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr2:110373405G>T	uc002tfb.3	+	0	1495	c.1339G>T	c.(1339-1341)Ggg>Tgg	p.G447W	SEPT10_uc010ywu.1_5'Flank|SEPT10_uc002tew.3_5'Flank|SEPT10_uc002tex.3_5'Flank|SEPT10_uc002tey.3_5'Flank|SEPT10_uc010ywv.2_5'Flank	NM_023016	NP_075392	Q53LP3	ANR57_HUMAN	Homo sapiens sosondowah ankyrin repeat domain family member C (SOWAHC), mRNA.	447																	CTCGGCTGAGGGGTGGGTCGG	0.552000													3	82					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				42	64					0	0	1	0	0
MTMR1	8776	broad.mit.edu	37	X	149931175	149931175	+	Silent	SNP	C	C	T			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chrX:149931175C>T	uc004feh.1	+	15	2130	c.1995C>T	c.(1993-1995)tcC>tcT	p.S665S	MTMR1_uc011mya.1_Silent_p.S563S|MTMR1_uc004fei.3_Silent_p.S657S|MTMR1_uc004fej.3_Non-coding_Transcript|MTMR1_uc010ntf.3_Intron	NM_003828	NP_003819	Q13613	MTMR1_HUMAN	Homo sapiens myotubularin related protein 1 (MTMR1), mRNA.	657						plasma membrane	protein tyrosine phosphatase activity	p.S657S(1)		central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCCACTCCGCCACCTCCG	0.672000													20	62					0	0	1	0	0
ORAI2	80228	broad.mit.edu	37	7	102087134	102087134	+	Missense_Mutation	SNP	A	A	T			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr7:102087134A>T	uc010lhz.1	+	3	635	c.400A>T	c.(400-402)Atc>Ttc	p.I134F	ORAI2_uc003uzj.2_Missense_Mutation_p.I134F|ORAI2_uc003uzk.2_Missense_Mutation_p.I134F|ORAI2_uc011kks.1_Missense_Mutation_p.I57F	NM_001126340	NP_116220	Q96SN7	ORAI2_HUMAN	Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 1, mRNA.	134						integral to membrane	protein binding	p.S133A(1)		autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|lung(4)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15						CCTGAACTCCATCAGCGAGTC	0.627000													5	230					0	0	1	0	0
DBN1	1627	broad.mit.edu	37	5	176886214	176886214	+	Silent	SNP	G	G	A			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chr5:176886214G>A	uc003mgx.2	-	11	1299	c.1017C>T	c.(1015-1017)agC>agT	p.S339S	DBN1_uc011dga.1_Silent_p.S69S|DBN1_uc003mgy.2_Silent_p.S337S|DBN1_uc010jkn.1_Silent_p.S287S|DBN1_uc003mgz.1_Silent_p.S320S	NM_080881	NP_543157	Q16643	DREB_HUMAN	Homo sapiens drebrin 1 (DBN1), transcript variant 2, mRNA.	337					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(12)|ovary(1)|skin(2)	25	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGTCAGACGGGCTCCGCGTGG	0.697000													4	215					0	0	1	0	0
BC018860	0	broad.mit.edu	37	M	7207	7208	+	Frame_Shift_Ins	INS	-	-	T			TCGA-E3-A3E1-01A-11D-A20C-08	TCGA-E3-A3E1-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d327ae2c-248b-4733-9115-0294a3875e62	e7c8d85b-e62d-42f9-9600-f635b50dd69e	g.chrM:7207_7208insT	uc011mfh.2	+	0	1307_1308	c.306_307insT	c.(304-309)cggaatfs	p.R102fs	JA429830_uc022bqp.1_5'Flank|JA429831_uc022bqq.1_5'Flank|JA429505_uc022bqr.1_5'Flank|OK/SW-cl.16_uc011mfi.2_5'Flank|AD_1_uc022bqu.1_5'Flank					Homo sapiens cDNA: FLJ22894 fis, clone KAT04907.																		CGGCCTATCCGGAATGCCCCGA	0.436													4	9	---	---	---	---