Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
COL6A6	131873	broad.mit.edu	37	3	130284243	130284243	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A4K4-01A-11D-A257-08	TCGA-EL-A4K4-11A-21D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23d4113a-f9a3-4581-a160-6074c4ef4dfe	4a0d57bd-9de2-4474-b547-f24b85e050d1	g.chr3:130284243G>A	uc010htl.3	+	2	1098	c.1067G>A	c.(1066-1068)cGa>cAa	p.R356Q		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	Homo sapiens collagen, type VI, alpha 6 (COL6A6), mRNA.	356	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GTTAACCTCCGACGGGAGGGT	0.567000													56	66					0	0	1	0	0
ITCH	83737	broad.mit.edu	37	20	33057876	33057876	+	Missense_Mutation	SNP	A	A	G			TCGA-EL-A4K4-01A-11D-A257-08	TCGA-EL-A4K4-11A-21D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23d4113a-f9a3-4581-a160-6074c4ef4dfe	4a0d57bd-9de2-4474-b547-f24b85e050d1	g.chr20:33057876A>G	uc010geu.1	+	15	1763	c.1571A>G	c.(1570-1572)tAt>tGt	p.Y524C	ITCH_uc002xak.2_Missense_Mutation_p.Y483C|ITCH_uc010zuj.1_Missense_Mutation_p.Y373C	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	Homo sapiens itchy E3 ubiquitin protein ligase homolog (mouse) (ITCH), mRNA.	524					apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						CAGATAGCCTATGTTCGGGAC	0.408000													49	103					0	0	1	0	0
EMILIN3	90187	broad.mit.edu	37	20	39991087	39991087	+	Silent	SNP	C	C	T			TCGA-EL-A4K4-01A-11D-A257-08	TCGA-EL-A4K4-11A-21D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23d4113a-f9a3-4581-a160-6074c4ef4dfe	4a0d57bd-9de2-4474-b547-f24b85e050d1	g.chr20:39991087C>T	uc002xjy.1	-	3	1346	c.1122G>A	c.(1120-1122)caG>caA	p.Q374Q		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	Homo sapiens elastin microfibril interfacer 3 (EMILIN3), mRNA.	374						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				CGCTCAGGCCCTGCAGCTGGC	0.672000													3	21					0	0	1	0	0
ADO	84890	broad.mit.edu	37	10	64565221	64565221	+	Missense_Mutation	SNP	C	C	A			TCGA-EL-A4K4-01A-11D-A257-08	TCGA-EL-A4K4-11A-21D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23d4113a-f9a3-4581-a160-6074c4ef4dfe	4a0d57bd-9de2-4474-b547-f24b85e050d1	g.chr10:64565221C>A	uc001jmg.3	+	0	706	c.402C>A	c.(400-402)gaC>gaA	p.D134E		NM_032804	NP_116193	Q96SZ5	AEDO_HUMAN	Homo sapiens 2-aminoethanethiol (cysteamine) dioxygenase (ADO), mRNA.	134							cysteamine dioxygenase activity|metal ion binding			lung(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					GCTGCATGGACAAGCTAGACG	0.716000													2	0					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EL-A4K4-01A-11D-A257-08	TCGA-EL-A4K4-11A-21D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23d4113a-f9a3-4581-a160-6074c4ef4dfe	4a0d57bd-9de2-4474-b547-f24b85e050d1	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				14	39					0	0	1	0	0
OR10H2	26538	broad.mit.edu	37	19	15839218	15839218	+	Missense_Mutation	SNP	G	G	A	rs145907157		TCGA-EL-A4K4-01A-11D-A257-08	TCGA-EL-A4K4-11A-21D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23d4113a-f9a3-4581-a160-6074c4ef4dfe	4a0d57bd-9de2-4474-b547-f24b85e050d1	g.chr19:15839218G>A	uc002nbm.2	+	0	385	c.365G>A	c.(364-366)cGc>cAc	p.R122H		NM_013939	NP_039227	O60403	O10H2_HUMAN	Homo sapiens olfactory receptor, family 10, subfamily H, member 2 (OR10H2), mRNA.	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D121Y(1)		breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					GGCTACGACCGCTACGTGGCC	0.647000													24	40					0	0	1	0	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5624780	5624780	+	Missense_Mutation	SNP	C	C	T	rs61758093		TCGA-EL-A4K4-01A-11D-A257-08	TCGA-EL-A4K4-11A-21D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23d4113a-f9a3-4581-a160-6074c4ef4dfe	4a0d57bd-9de2-4474-b547-f24b85e050d1	g.chr11:5624780C>T	uc001mbf.3	+	1	585	c.322C>T	c.(322-324)Cgg>Tgg	p.R108W	HBG1_uc001mak.1_Intron|TRIM6-TRIM34_uc009yeo.2_Missense_Mutation_p.R80W|TRIM6-TRIM34_uc010qzj.2_Intron|TRIM6-TRIM34_uc001mbc.2_Missense_Mutation_p.R80W|TRIM6-TRIM34_uc001mbe.3_Intron|TRIM6-TRIM34_uc001mbd.3_Missense_Mutation_p.R108W|TRIM6-TRIM34_uc010qzk.2_Intron|TRIM6-TRIM34_uc010qzl.2_Intron|TRIM6-TRIM34_uc009yep.1_5'Flank	NM_001003819	NP_067629	B2RNG4	B2RNG4_HUMAN	Homo sapiens TRIM6-TRIM34 readthrough (TRIM6-TRIM34), mRNA.	108						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		CATAGTGAGGCGGCTCAGAGA	0.552000													10	43					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124827559	124827559	+	Missense_Mutation	SNP	A	A	T			TCGA-EL-A4K4-01A-11D-A257-08	TCGA-EL-A4K4-11A-21D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23d4113a-f9a3-4581-a160-6074c4ef4dfe	4a0d57bd-9de2-4474-b547-f24b85e050d1	g.chr12:124827559A>T	uc021rga.1	-	32	5066	c.4949T>A	c.(4948-4950)cTg>cAg	p.L1650Q	NCOR2_uc021rgb.1_Missense_Mutation_p.L1634Q|NCOR2_uc010tbb.2_Missense_Mutation_p.L1643Q|NCOR2_uc010tbc.2_Missense_Mutation_p.L1633Q|NCOR2_uc021rgc.1_Missense_Mutation_p.L1633Q|NCOR2_uc010tba.2_Missense_Mutation_p.L1651Q|NCOR2_uc010tax.2_5'Flank	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	Homo sapiens nuclear receptor corepressor 2 (NCOR2), transcript variant 1, mRNA.	1651					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|Notch binding|histone deacetylase binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		ACCTGCGTCCAGAGGGATGCC	0.637000													3	22					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49689975	49689975	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A4K4-01A-11D-A257-08	TCGA-EL-A4K4-11A-21D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23d4113a-f9a3-4581-a160-6074c4ef4dfe	4a0d57bd-9de2-4474-b547-f24b85e050d1	g.chr3:49689975C>T	uc003cxe.4	+	4	3100	c.2986C>T	c.(2986-2988)Ccc>Tcc	p.P996S		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	Homo sapiens bassoon (presynaptic cytomatrix protein) (BSN), mRNA.	996					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGGCACCTCTCCCACCTCTCT	0.647000													15	23					0	0	1	0	0
LACTB	114294	broad.mit.edu	37	15	63414116	63414116	+	Frame_Shift_Del	DEL	G	G	-	rs34925488	byFrequency	TCGA-EL-A4K4-01A-11D-A257-08	TCGA-EL-A4K4-11A-21D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23d4113a-f9a3-4581-a160-6074c4ef4dfe	4a0d57bd-9de2-4474-b547-f24b85e050d1	g.chr15:63414116delG	uc002alw.3	+	0	118	c.46delG	c.(46-48)gggfs	p.G16fs	LACTB_uc002alv.3_Frame_Shift_Del_p.G16fs	NM_032857	NP_116246	P83111	LACTB_HUMAN	Homo sapiens lactamase, beta (LACTB), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	16						mitochondrion	hydrolase activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(1)	12						TGCCGCCCCCGGGGGCTTGGC	0.751													2	4	---	---	---	---					
MSRB1	51734	broad.mit.edu	37	16	1993132	1993132	+	Frame_Shift_Del	DEL	C	C	-			TCGA-EL-A4K4-01A-11D-A257-08	TCGA-EL-A4K4-11A-21D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23d4113a-f9a3-4581-a160-6074c4ef4dfe	4a0d57bd-9de2-4474-b547-f24b85e050d1	g.chr16:1993132delC	uc021tam.1	-	0	163	c.26delG	c.(25-27)ggcfs	p.G9fs	TCRBV20S1_uc021tak.1_Intron	NM_016332	NP_057416	Q9NZV6	MSRB1_HUMAN	Homo sapiens selenoprotein X, 1 (SEPX1), mRNA.	9					protein repair	cytoplasm|nucleus	peptide-methionine-(S)-S-oxide reductase activity|zinc ion binding									L-Methionine(DB00134)	GAAAACCTCGCCCCCGAAGAA	0.697													2	4	---	---	---	---