Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GRIK1	2897	broad.mit.edu	37	21	31023467	31023467	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr21:31023467C>T	uc011acs.2	-	5	1389	c.925G>A	c.(925-927)Gag>Aag	p.E309K	GRIK1_uc002ynn.3_Missense_Mutation_p.E309K|GRIK1_uc011act.2_Missense_Mutation_p.E253K|GRIK1_uc002yno.1_Missense_Mutation_p.E309K|GRIK1_uc010glq.1_Missense_Mutation_p.E167K|GRIK1_uc002ynr.3_Missense_Mutation_p.E309K	NM_000830	NP_000821	P39086	GRIK1_HUMAN	Homo sapiens glutamate receptor, ionotropic, kainate 1 (GRIK1), transcript variant 1, mRNA.	309					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity	p.E309K(3)|p.E309E(1)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	AGGCCAGTCTCGGGCCTGGGT	0.463000													11	62					0	0	1	0	0
CTTN	2017	broad.mit.edu	37	11	70282508	70282508	+	Silent	SNP	C	C	T			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr11:70282508C>T	uc001opu.3	+	18	2105	c.1899C>T	c.(1897-1899)tgC>tgT	p.C633C	CTTN_uc001opv.4_3'UTR|CTTN_uc001opw.4_3'UTR|CTTN_uc001opx.3_3'UTR	NM_001184740	NP_001171669	Q14247	SRC8_HUMAN	Homo sapiens cortactin (CTTN), transcript variant 3, mRNA.	0						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		TCCCGGAGTGCCCGTGAAGCG	0.532000													4	176					0	0	1	0	0
EDDM3B	64184	broad.mit.edu	37	14	21238577	21238577	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr14:21238577C>T	uc001vyd.3	+	1	366	c.268C>T	c.(268-270)Cga>Tga	p.R90*	EDDM3B_uc021ron.1_Nonsense_Mutation_p.R90*	NM_022360	NP_071755	P56851	EP3B_HUMAN	Homo sapiens epididymal protein 3B (EDDM3B), mRNA.	90					spermatid development	extracellular region				central_nervous_system(1)|kidney(1)|lung(3)|ovary(1)|skin(1)	7						GGATCGCTTCCGAAATGCATA	0.408000													58	63					0	0	1	0	0
PCSK1	5122	broad.mit.edu	37	5	95735729	95735729	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr5:95735729G>A	uc003kls.2	-	9	1597	c.1358C>T	c.(1357-1359)gCt>gTt	p.A453V	PCSK1_uc010jbi.2_Missense_Mutation_p.A143V|PCSK1_uc021ybq.1_Missense_Mutation_p.A406V	NM_000439	NP_000430	P29120	NEC1_HUMAN	Homo sapiens proprotein convertase subtilisin/kexin type 1 (PCSK1), transcript variant 1, mRNA.	453					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCTGGGGTCAGCTAAATCCAC	0.463000													3	91					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113529419	113529419	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr8:113529419G>A	uc003ynu.3	-	27	4759	c.4600C>T	c.(4600-4602)Ccc>Tcc	p.P1534S	CSMD3_uc003yns.3_Missense_Mutation_p.P806S|CSMD3_uc003ynt.3_Missense_Mutation_p.P1494S|CSMD3_uc011lhx.2_Missense_Mutation_p.P1430S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	Homo sapiens CUB and Sushi multiple domains 3 (CSMD3), transcript variant a, mRNA.	1534	Sushi 8.					integral to membrane|plasma membrane		p.P1534T(2)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CCATTCATGGGGACCCCTGGG	0.428000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			3	32					0	0	1	0	0
NCAPG2	54892	broad.mit.edu	37	7	158448053	158448053	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr7:158448053A>G	uc011kwe.1	-	19	2628	c.2483T>C	c.(2482-2484)cTg>cCg	p.L828P	NCAPG2_uc010lqu.1_Missense_Mutation_p.L620P|NCAPG2_uc003wnx.1_Missense_Mutation_p.L828P|NCAPG2_uc003wnv.1_Missense_Mutation_p.L828P|NCAPG2_uc003wnw.1_Non-coding_Transcript|NCAPG2_uc011kwc.1_Missense_Mutation_p.L329P|NCAPG2_uc011kwd.1_Missense_Mutation_p.L271P	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	Homo sapiens non-SMC condensin II complex, subunit G2 (NCAPG2), mRNA.	828					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	39	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		ATGGATGCTCAGGCGACAGTG	0.522000													4	481					0	0	1	0	0
PI4K2B	55300	broad.mit.edu	37	4	25265420	25265420	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr4:25265420A>G	uc003grk.2	+	6	1160	c.1027A>G	c.(1027-1029)Att>Gtt	p.I343V	PI4K2B_uc011bxs.2_Missense_Mutation_p.I247V	NM_018323	NP_060793	Q8TCG2	P4K2B_HUMAN	Homo sapiens phosphatidylinositol 4-kinase type 2 beta (PI4K2B), mRNA.	343	PI3K/PI4K.					cytoplasm|membrane	1-phosphatidylinositol 4-kinase activity|ATP binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(3)|skin(3)	15		Breast(46;0.173)				AATAGCTGCAATTGATAATGG	0.303000													41	50					0	0	1	0	0
GPX8	493869	broad.mit.edu	37	5	54456042	54456042	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr5:54456042C>T	uc003jpq.2	+	0	59	c.22C>T	c.(22-24)Ccg>Tcg	p.P8S	CDC20B_uc003jpo.2_Intron|CDC20B_uc003jpn.2_Intron|CDC20B_uc010ivu.2_Intron|CDC20B_uc010ivv.2_Intron|CDC20B_uc003jpp.3_Intron|GPX8_uc003jpr.2_Missense_Mutation_p.P8S|GPX8_uc003jps.2_Non-coding_Transcript|GPX8_uc003jpt.2_Missense_Mutation_p.P8S	NM_001008397	NP_001008398	Q8TED1	GPX8_HUMAN	Homo sapiens glutathione peroxidase 8 (putative) (GPX8), mRNA.	8					response to oxidative stress	integral to membrane	glutathione peroxidase activity	p.P8P(2)		breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|prostate(1)	11					Glutathione(DB00143)	TGCAGCTTACCCGCTAAAATG	0.448000													45	40					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62657293	62657293	+	Splice_Site	SNP	C	C	T			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr20:62657293C>T	uc002yho.3	+	15	2077	c.1909_splice	c.e15-1	p.A637_splice	PRPF6_uc002yhp.3_Intron	NM_012469	NP_036601	O94906	PRP6_HUMAN	Homo sapiens PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) (PRPF6), mRNA.	637					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP|catalytic step 2 spliceosome|nucleoplasm	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GCCCTTCAGGCCAACCCCAAC	0.612000													127	419					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131484927	131484927	+	Splice_Site	SNP	G	G	C			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr12:131484927G>C	uc010tbm.2	+	10	1622	c.1063_splice	c.e10-1	p.T355_splice	GPR133_uc001uit.4_Splice_Site_p.T323_splice	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	Homo sapiens G protein-coupled receptor 133 (GPR133), mRNA.	323					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TCCACCTTTAGACCTTCTTAA	0.478000													28	95					0	0	1	0	0
EFNB3	1949	broad.mit.edu	37	17	7612771	7612771	+	Silent	SNP	C	C	T			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr17:7612771C>T	uc002gis.3	+	4	1297	c.900C>T	c.(898-900)ggC>ggT	p.G300G		NM_001406	NP_001397	Q15768	EFNB3_HUMAN	Homo sapiens ephrin-B3 (EFNB3), mRNA.	300					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				TGCGGGGTGGCGGGGCTGCAG	0.667000													15	85					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409977	105409977	+	Silent	SNP	G	G	A			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr14:105409977G>A	uc010axc.1	-	6	11931	c.11811C>T	c.(11809-11811)gaC>gaT	p.D3937D	AHNAK2_uc021sen.1_5'Flank|AHNAK2_uc021seo.1_Intron|AHNAK2_uc001ypx.2_Silent_p.D3837D	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	Homo sapiens AHNAK nucleoprotein 2 (AHNAK2), mRNA.	3937						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGCCTCGACGTCCACCTCCA	0.597000													6	408					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45511884	45511884	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr21:45511884A>G	uc002zea.3	+	18	3120	c.2951A>G	c.(2950-2952)gAt>gGt	p.D984G	TRAPPC10_uc010gpo.3_Missense_Mutation_p.D695G|TRAPPC10_uc011afa.2_Missense_Mutation_p.D362G|TRAPPC10_uc011afb.1_Missense_Mutation_p.D89G	NM_003274	NP_003265	P48553	TPC10_HUMAN	Homo sapiens trafficking protein particle complex 10 (TRAPPC10), mRNA.	984					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity	p.G983D(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						GATACCGGTGATAGTACCGAC	0.408000													4	123					0	0	1	0	0
SPATA25	128497	broad.mit.edu	37	20	44515629	44515629	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr20:44515629T>C	uc002xqf.3	-	1	220	c.211A>G	c.(211-213)Agg>Ggg	p.R71G		NM_080608	NP_542175	Q9BR10	CT165_HUMAN	Homo sapiens spermatogenesis associated 25 (SPATA25), mRNA.	71						integral to membrane											GGGCAGCCCCTGGCTTGTGGC	0.642000													73	210					0	0	1	0	0
MST4	51765	broad.mit.edu	37	X	131205246	131205246	+	Splice_Site	SNP	G	G	A			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chrX:131205246G>A	uc011mux.1	+	9	1299	c.998_splice	c.e9+1	p.S333_splice	MST4_uc004ewk.1_Splice_Site_p.S311_splice|MST4_uc004ewl.1_Splice_Site_p.S234_splice|MST4_uc010nrj.1_Splice_Site_p.S311_splice|MST4_uc004ewm.1_Splice_Site_p.S249_splice	NM_016542	NP_057626	Q9P289	MST4_HUMAN	Homo sapiens serine/threonine protein kinase MST4 (MST4), transcript variant 1, mRNA.	311					cellular component disassembly involved in apoptosis|regulation of apoptosis	Golgi membrane|cytosol	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(192;0.000127)					GCTCTGATTCGTATGTACAAA	0.348000													12	110					0	0	1	0	0
ELL	8178	broad.mit.edu	37	19	18572546	18572546	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr19:18572546C>T	uc002njh.3	-	4	658	c.586G>A	c.(586-588)Gtg>Atg	p.V196M	ELL_uc010ebq.3_Missense_Mutation_p.V139M|ELL_uc002njg.3_Missense_Mutation_p.V63M	NM_006532	NP_006523	P55199	ELL_HUMAN	Homo sapiens elongation factor RNA polymerase II (ELL), mRNA.	196					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(5)|prostate(1)	19				GBM - Glioblastoma multiforme(1328;7.81e-07)		CCCCCACTCACGGCACTGGCA	0.667000			T	MLL	AL						OREG0025366	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	39					0	0	1	0	0
NEDD4L	23327	broad.mit.edu	37	18	55998052	55998052	+	Missense_Mutation	SNP	G	G	T			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr18:55998052G>T	uc002lgy.3	+	10	1179	c.896G>T	c.(895-897)gGa>gTa	p.G299V	NEDD4L_uc002lgz.3_Missense_Mutation_p.G299V|NEDD4L_uc002lgx.3_Missense_Mutation_p.G299V|NEDD4L_uc010xee.1_Missense_Mutation_p.G178V|NEDD4L_uc002lhc.2_Missense_Mutation_p.G291V|NEDD4L_uc002lhd.2_Missense_Mutation_p.G178V|NEDD4L_uc002lhb.2_Missense_Mutation_p.G178V|NEDD4L_uc002lhe.2_Missense_Mutation_p.G291V|NEDD4L_uc002lhf.3_Missense_Mutation_p.G178V|NEDD4L_uc002lhg.3_Missense_Mutation_p.G178V|NEDD4L_uc002lhh.2_Missense_Mutation_p.G178V|NEDD4L_uc010dpm.1_Missense_Mutation_p.G150V	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	Homo sapiens neural precursor cell expressed, developmentally down-regulated 4-like (NEDD4L), transcript variant j, mRNA.	299					cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			breast(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(11)|ovary(1)|prostate(4)	37						GCCTCCCCAGGATCTCGGACC	0.542000													6	47					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133885318	133885318	+	Missense_Mutation	SNP	T	T	G			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr8:133885318T>G	uc003ytw.3	+	4	531	c.490T>G	c.(490-492)Tgt>Ggt	p.C164G		NM_003235	NP_003226	P01266	THYG_HUMAN	Homo sapiens thyroglobulin (TG), mRNA.	164	Thyroglobulin type-1 3.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TCCAAGGAGCTGTGAAATAAG	0.448000													5	36					0	0	1	0	0
PRKAG2	51422	broad.mit.edu	37	7	151573629	151573629	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr7:151573629G>A	uc003wkk.3	-	0	688	c.77C>T	c.(76-78)gCc>gTc	p.A26V	PRKAG2_uc010lqe.1_Non-coding_Transcript|PRKAG2_uc003wkm.1_Missense_Mutation_p.A26V|LOC100505483_uc003wko.2_5'Flank	NM_016203	NP_077747	Q9UGJ0	AAKG2_HUMAN	Homo sapiens protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2), transcript variant a, mRNA.	26					ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|upper_aerodigestive_tract(1)	26	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		CTTCTGGCTGGCATTTTTCTT	0.607000													4	150					0	0	1	0	0
ZNF850	342892	broad.mit.edu	37	19	37238763	37238764	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-EM-A3AI-01A-11D-A202-08	TCGA-EM-A3AI-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e2d60229-ba66-4c45-968a-72292b48add3	466ebb6e-b9e9-4556-9f48-3b7685f0f4e2	g.chr19:37238763_37238764delGT	uc010efc.3	-	4	3337_3338	c.3178_3179delAC	c.(3178-3180)actfs	p.T1060fs	ZNF850_uc010xtm.2_Frame_Shift_Del_p.T1026fs	NM_001193552	NP_001180481	A8MQ14	ZN850_HUMAN	Homo sapiens zinc finger protein 850 (ZNF850), mRNA.	1060					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										TTTCTCGCCAGTGTGAACACTC	0.421													2	4	---	---	---	---