Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CTAGE5	4253	broad.mit.edu	37	14	39763206	39763206	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3BX-01A-11D-A19J-08	TCGA-ET-A3BX-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81ac96ae-fa67-46a4-a969-cd269e0a45ea	b5eda881-51a0-4255-bd6a-bbb070d97793	g.chr14:39763206G>A	uc001wvi.4	+	6	849	c.513G>A	c.(511-513)atG>atA	p.M171I	CTAGE5_uc010tqe.1_Missense_Mutation_p.M128I|CTAGE5_uc001wuy.4_Missense_Mutation_p.M86I|CTAGE5_uc001wuz.4_Missense_Mutation_p.M154I|CTAGE5_uc001wva.4_Missense_Mutation_p.M137I|CTAGE5_uc001wvb.4_Missense_Mutation_p.M137I|CTAGE5_uc001wvc.4_Missense_Mutation_p.M111I|CTAGE5_uc001wve.1_Missense_Mutation_p.M142I|CTAGE5_uc001wvf.4_Missense_Mutation_p.M91I|CTAGE5_uc001wvg.4_Missense_Mutation_p.M166I|CTAGE5_uc001wvh.4_Missense_Mutation_p.M166I|CTAGE5_uc010amz.3_5'UTR|CTAGE5_uc001wvj.4_Missense_Mutation_p.M137I	NM_001247989	NP_001234918	O15320	CTGE5_HUMAN	Homo sapiens CTAGE family, member 5 (CTAGE5), transcript variant 6, mRNA.	166							enzyme activator activity|protein binding		CTAGE5/SIP1(2)	breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		GTTTCTAGATGGCGGATATTT	0.343000													44	59					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152329145	152329145	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A3BX-01A-11D-A19J-08	TCGA-ET-A3BX-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81ac96ae-fa67-46a4-a969-cd269e0a45ea	b5eda881-51a0-4255-bd6a-bbb070d97793	g.chr1:152329145C>T	uc001ezw.4	-	2	1190	c.1117G>A	c.(1117-1119)Ggc>Agc	p.G373S	AK056431_uc001ezv.3_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	Homo sapiens filaggrin family member 2 (FLG2), mRNA.	373	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACTTGAGCCTGTTCTCCAT	0.468000													34	52					0	0	1	0	0
TRAPPC5	126003	broad.mit.edu	37	19	7747624	7747624	+	Missense_Mutation	SNP	C	C	G			TCGA-ET-A3BX-01A-11D-A19J-08	TCGA-ET-A3BX-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81ac96ae-fa67-46a4-a969-cd269e0a45ea	b5eda881-51a0-4255-bd6a-bbb070d97793	g.chr19:7747624C>G	uc002mhi.1	+	1	555	c.485C>G	c.(484-486)gCg>gGg	p.A162G	TRAPPC5_uc002mhj.1_Missense_Mutation_p.A162G|TRAPPC5_uc002mhk.1_Missense_Mutation_p.A162G|TRAPPC5_uc021unw.1_Missense_Mutation_p.A162G	NM_001042462	NP_777554	Q8IUR0	TPPC5_HUMAN	Homo sapiens trafficking protein particle complex 5 (TRAPPC5), transcript variant 3, mRNA.	162					vesicle-mediated transport	endoplasmic reticulum	guanylate cyclase activity|heme binding			NS(1)|lung(2)	3						AAGGTCACGGCGCACTGGCAC	0.652000													6	6					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12382678	12382678	+	Missense_Mutation	SNP	C	C	G			TCGA-ET-A3BX-01A-11D-A19J-08	TCGA-ET-A3BX-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81ac96ae-fa67-46a4-a969-cd269e0a45ea	b5eda881-51a0-4255-bd6a-bbb070d97793	g.chr1:12382678C>G	uc001atv.3	+	33	7931	c.7790C>G	c.(7789-7791)gCt>gGt	p.A2597G	VPS13D_uc001atw.3_Missense_Mutation_p.A2597G|VPS13D_uc001atx.3_Missense_Mutation_p.A1785G|VPS13D_uc001aty.1_Missense_Mutation_p.A335G	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	Homo sapiens vacuolar protein sorting 13 homolog D (S. cerevisiae) (VPS13D), transcript variant 1, mRNA.	2597					protein localization			p.A2597D(2)		NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCAGAGCAAGCTAATGCTGCA	0.473000													29	49					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20489432	20489432	+	RNA	SNP	G	G	A			TCGA-ET-A3BX-01A-11D-A19J-08	TCGA-ET-A3BX-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81ac96ae-fa67-46a4-a969-cd269e0a45ea	b5eda881-51a0-4255-bd6a-bbb070d97793	g.chr15:20489432G>A	uc001ytf.1	+	2		c.420G>A								Homo sapiens checkpoint kinase 2 pseudogene 2 (CHEK2P2), non-coding RNA.																		GTCACTGAAGGACCAGATCAC	0.418000													7	128					0	0	1	0	0
MOB1A	55233	broad.mit.edu	37	2	74392437	74392437	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3BX-01A-11D-A19J-08	TCGA-ET-A3BX-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81ac96ae-fa67-46a4-a969-cd269e0a45ea	b5eda881-51a0-4255-bd6a-bbb070d97793	g.chr2:74392437G>A	uc002skh.4	-	3	511	c.317C>T	c.(316-318)cCa>cTa	p.P106L	MOB1A_uc002ski.2_Missense_Mutation_p.P106L	NM_018221	NP_060691	Q9H8S9	MOL1B_HUMAN	Homo sapiens MOB kinase activator 1A (MOB1A), mRNA.	106					hippo signaling cascade		metal ion binding|protein binding										ACATTTGATTGGCTTTTTAAT	0.303000													5	9					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-ET-A3BX-01A-11D-A19J-08	TCGA-ET-A3BX-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81ac96ae-fa67-46a4-a969-cd269e0a45ea	b5eda881-51a0-4255-bd6a-bbb070d97793	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				26	37					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41021270	41021270	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3BX-01A-11D-A19J-08	TCGA-ET-A3BX-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81ac96ae-fa67-46a4-a969-cd269e0a45ea	b5eda881-51a0-4255-bd6a-bbb070d97793	g.chr19:41021270G>A	uc002ony.3	+	14	2904	c.2818G>A	c.(2818-2820)Gtg>Atg	p.V940M	SPTBN4_uc002onx.3_Missense_Mutation_p.V940M|SPTBN4_uc002onz.3_Missense_Mutation_p.V940M|SPTBN4_uc010egx.3_5'UTR	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	Homo sapiens spectrin, beta, non-erythrocytic 4 (SPTBN4), transcript variant sigma1, mRNA.	940					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	PML body|cytosol|nuclear matrix|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CGTTCTGGACGTGAACCACAC	0.612000													3	14					0	0	1	0	0
UPK3A	7380	broad.mit.edu	37	22	45691583	45691583	+	Missense_Mutation	SNP	A	A	G			TCGA-ET-A3BX-01A-11D-A19J-08	TCGA-ET-A3BX-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81ac96ae-fa67-46a4-a969-cd269e0a45ea	b5eda881-51a0-4255-bd6a-bbb070d97793	g.chr22:45691583A>G	uc003bfy.3	+	5	874	c.847A>G	c.(847-849)Agc>Ggc	p.S283G	UPK3A_uc010gzy.3_Missense_Mutation_p.S162G	NM_006953	NP_008884	O75631	UPK3A_HUMAN	Homo sapiens uroplakin 3A (UPK3A), transcript variant 1, mRNA.	283					epithelial cell differentiation	endoplasmic reticulum membrane|integral to membrane				kidney(1)|large_intestine(1)|lung(2)|skin(1)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		GGTGTATTCCAGCAAGCTCCA	0.637000													3	37					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88379615	88379615	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ET-A3BX-01A-11D-A19J-08	TCGA-ET-A3BX-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81ac96ae-fa67-46a4-a969-cd269e0a45ea	b5eda881-51a0-4255-bd6a-bbb070d97793	g.chr12:88379615delA	uc001tan.3	-	9	1432	c.1183delT	c.(1183-1185)tgtfs	p.C395fs	C12orf50_uc001tam.1_Intron	NM_152589	NP_689802	Q8NA57	CL050_HUMAN	Homo sapiens chromosome 12 open reading frame 50 (C12orf50), mRNA.	0								p.S395L(1)		NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						CCACATCAACAAAGGACCTCA	0.488													33	62	---	---	---	---					
CACNA1G	8913	broad.mit.edu	37	17	48653257	48653257	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ET-A3BX-01A-11D-A19J-08	TCGA-ET-A3BX-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81ac96ae-fa67-46a4-a969-cd269e0a45ea	b5eda881-51a0-4255-bd6a-bbb070d97793	g.chr17:48653257delC	uc002irk.1	+	7	1866	c.1494delC	c.(1492-1494)cacfs	p.H498fs	CACNA1G_uc002iri.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002irj.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002irl.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002irm.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002irn.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002iro.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002irp.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002irq.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002irr.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002irs.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002irt.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002iru.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002irv.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002irw.1_Frame_Shift_Del_p.H498fs|CACNA1G_uc002irx.1_Frame_Shift_Del_p.H411fs|CACNA1G_uc002iry.1_Frame_Shift_Del_p.H411fs|CACNA1G_uc002isg.1_Frame_Shift_Del_p.H411fs|CACNA1G_uc002ish.1_Frame_Shift_Del_p.H411fs|CACNA1G_uc002isi.1_Frame_Shift_Del_p.H411fs|CACNA1G_uc002irz.1_Frame_Shift_Del_p.H411fs|CACNA1G_uc002isa.1_Frame_Shift_Del_p.H411fs|CACNA1G_uc002isd.1_Frame_Shift_Del_p.H411fs|CACNA1G_uc002isb.1_Frame_Shift_Del_p.H411fs|CACNA1G_uc002isc.1_Frame_Shift_Del_p.H411fs|CACNA1G_uc002ise.1_Frame_Shift_Del_p.H411fs|CACNA1G_uc002isf.1_Frame_Shift_Del_p.H411fs	NM_018896	NP_061496	O43497	CAC1G_HUMAN	Homo sapiens calcium channel, voltage-dependent, T type, alpha 1G subunit (CACNA1G), transcript variant 1, mRNA.	498	Poly-His.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TGcaccaccaccaccaccatc	0.706													2	4	---	---	---	---