Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANKRD36	375248	broad.mit.edu	37	2	97867956	97867956	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr2:97867956C>T	ENST00000420699.2	+	47	3119	c.2875C>T	c.(2875-2877)Cca>Tca	p.P959S	ANKRD36_ENST00000461153.2_Missense_Mutation_p.P959S	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	959										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						TCAGAAACCACCAGCCTTGAA	0.333000													4	53					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	C	T	rs144465613	byFrequency	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr14:23887583C>T	ENST00000355349.3	-	30	4167	c.4005G>A	c.(4003-4005)tcG>tcA	p.S1335S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.S1335S(3)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662000													4	63					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53045843	53045843	+	Silent	SNP	G	G	A			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr8:53045843G>A	ENST00000276480.7	-	20	3002	c.2319C>T	c.(2317-2319)tgC>tgT	p.C773C		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	773						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CCGAGCCATCGCAGCCTGGGG	0.522000													20	42					0	0	1	0	0
DDN	23109	broad.mit.edu	37	12	49392347	49392347	+	Silent	SNP	C	C	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr12:49392347C>T	ENST00000421952.2	-	2	333	c.312G>A	c.(310-312)gaG>gaA	p.E104E	RP11-386G11.5_ENST00000547866.1_RNA|RP11-386G11.5_ENST00000552933.1_RNA|RP11-386G11.5_ENST00000552284.1_RNA|RP11-386G11.5_ENST00000547395.1_RNA	NM_015086.1	NP_055901.2	O94850	DEND_HUMAN	dendrin	104						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				NS(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	8						GAGCTCGGACCTCGGCCAGGG	0.741000													15	26					0	0	1	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32725596	32725596	+	Silent	SNP	C	C	G	rs115565146	by1000genomes	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr6:32725596C>G	ENST00000435145.2	-	4	772	c.711G>C	c.(709-711)ctG>ctC	p.L237L	HLA-DQB2_ENST00000411527.1_Intron|HLA-DQB2_ENST00000437316.2_Silent_p.L237L			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	216					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						CGAGGAAGATCAGCCCCAGCA	0.562000													4	20					0	0	1	0	0
ANGPT2	285	broad.mit.edu	37	8	6371296	6371296	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr8:6371296G>A	ENST00000325203.5	-	7	1576	c.1102C>T	c.(1102-1104)Cgc>Tgc	p.R368C	ANGPT2_ENST00000523120.1_Missense_Mutation_p.R367C|ANGPT2_ENST00000415216.1_Missense_Mutation_p.R367C|MCPH1_ENST00000344683.5_Intron|ANGPT2_ENST00000338312.6_Missense_Mutation_p.R316C			O15123	ANGP2_HUMAN	angiopoietin 2	368	Fibrinogen C-terminal.				angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding	p.R368C(4)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)		AGCACATAGCGTTGCTGATTA	0.363000													42	40					0	0	1	0	0
STAT5A	6776	broad.mit.edu	37	17	40447745	40447745	+	Silent	SNP	C	C	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr17:40447745C>T	ENST00000345506.4	+	6	1126	c.484C>T	c.(484-486)Ctg>Ttg	p.L162L	STAT5A_ENST00000452307.2_Silent_p.L162L|STAT5A_ENST00000588868.1_Silent_p.L162L|STAT5A_ENST00000546010.2_Silent_p.L132L|STAT5A_ENST00000590949.1_Silent_p.L162L	NM_003152.3	NP_003143.2	P42229	STA5A_HUMAN	signal transducer and activator of transcription 5A	162					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	14		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		AGAGAATGAGCTGAAGAAACT	0.567000													14	15					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135205596	135205596	+	Silent	SNP	T	T	A			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr9:135205596T>A	ENST00000372169.2	-	10	1571	c.1389A>T	c.(1387-1389)gtA>gtT	p.V463V	SETX_ENST00000393220.1_Silent_p.V463V|SETX_ENST00000224140.5_Silent_p.V463V			Q7Z333	SETX_HUMAN	senataxin	463					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CAATCACTGATACCAAAATTA	0.398000													4	48					0	0	1	0	0
MEN1	0	broad.mit.edu	37	11	64575521	64575521	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr11:64575521G>A	ENST00000337652.1	-	3	1014	c.511C>T	c.(511-513)Cag>Tag	p.Q171*	MEN1_ENST00000394376.1_Nonsense_Mutation_p.Q171*|MEN1_ENST00000377321.1_Nonsense_Mutation_p.Q166*|MEN1_ENST00000377313.1_Nonsense_Mutation_p.Q171*|MEN1_ENST00000394374.2_Nonsense_Mutation_p.Q171*|MEN1_ENST00000377326.3_Nonsense_Mutation_p.Q166*|MEN1_ENST00000443283.1_Nonsense_Mutation_p.Q171*|MEN1_ENST00000377316.2_Nonsense_Mutation_p.Q166*|MEN1_ENST00000312049.6_Nonsense_Mutation_p.Q166*|MEN1_ENST00000315422.4_Nonsense_Mutation_p.Q166*	NM_130803.2	NP_570715.1	O00255	MEN1_HUMAN	multiple endocrine neoplasia I	171			Missing (in MEN1).		DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			NS(7)|adrenal_gland(5)|breast(2)|central_nervous_system(5)|endometrium(1)|gastrointestinal_tract_(site_indeterminate)(15)|large_intestine(2)|lung(21)|ovary(1)|pancreas(64)|parathyroid(181)|pituitary(7)|prostate(4)|retroperitoneum(1)|skin(1)|small_intestine(13)|soft_tissue(4)|stomach(1)|thymus(2)	337						CCCAGGGCCTGGCAGGCCCCA	0.602000			"""D, Mis, N, F, S"""		"""parathyroid tumors, Pancreatic neuroendocrine tumors"""	"""parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid"""			Multiple Endocrine Neoplasia, type 1;Hyperparathyroidism, Familial Isolated				12	0					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24886268	24886268	+	Silent	SNP	C	C	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr14:24886268C>T	ENST00000382554.3	+	9	5631	c.5313C>T	c.(5311-5313)ccC>ccT	p.P1771P		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1771	Integrase catalytic.				DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TCACGGAGCCCCTGTGGTGGG	0.632000													44	34					0	0	1	0	0
RPS4X	6191	broad.mit.edu	37	X	71493125	71493125	+	Missense_Mutation	SNP	T	T	A			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chrX:71493125T>A	ENST00000316084.6	-	6	751	c.647A>T	c.(646-648)aAc>aTc	p.N216I	RPS4X_ENST00000486733.1_5'UTR	NM_001007.4	NP_000998.1	P62701	RS4X_HUMAN	ribosomal protein S4, X-linked	216					endocrine pancreas development|positive regulation of cell proliferation|positive regulation of translation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|polysome	rRNA binding|structural constituent of ribosome			NS(1)|large_intestine(1)	2	Renal(35;0.156)					GGCAAAGCTGTTGCCATTGGC	0.463000													40	0					0	0	1	0	0
NBPF15	284565	broad.mit.edu	37	1	148594439	148594439	+	Silent	SNP	A	A	G	rs146739148	byFrequency	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr1:148594439A>G	ENST00000442702.2	+	21	2879	c.1812A>G	c.(1810-1812)ttA>ttG	p.L604L	NBPF15_ENST00000369187.3_Silent_p.L604L	NM_001170755.1	NP_001164226.1	Q8N660	NBPFF_HUMAN	neuroblastoma breakpoint family, member 15	604	NBPF 6.					cytoplasm				NS(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12	all_hematologic(923;0.032)					CTGAAGTCTTACAGGACTCAC	0.463000													7	217					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40745381	40745381	+	Missense_Mutation	SNP	C	C	T	rs111691891		TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr12:40745381C>T	ENST00000298910.7	+	44	6480	c.6422C>T	c.(6421-6423)aCg>aTg	p.T2141M		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2141			T -> M (in PARK8).		activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding	p.T2141M(1)|p.T2148M(1)		NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GTCTGTCTGACGAGACGCATT	0.388000													19	33					0	0	1	0	0
OR12D3	81797	broad.mit.edu	37	6	29342445	29342445	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr6:29342445C>T	ENST00000396806.3	-	1	623	c.620G>A	c.(619-621)gGa>gAa	p.G207E	OR5V1_ENST00000377154.1_Intron	NM_030959.2	NP_112221.1	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D, member 3	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						AAAGAAAGCTCCCATGGATAT	0.448000													41	45					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32031962	32031962	+	Missense_Mutation	SNP	A	A	G	rs1808125	by1000genomes	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr3:32031962A>G	ENST00000360311.4	+	2	1940	c.1391A>G	c.(1390-1392)cAt>cGt	p.H464R		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						AAGACCTTCCATCACAATTCA	0.418000													4	71					0	0	1	0	0
KCNJ9	3765	broad.mit.edu	37	1	160054053	160054053	+	Missense_Mutation	SNP	T	T	A			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr1:160054053T>A	ENST00000368088.3	+	2	475	c.233T>A	c.(232-234)aTc>aAc	p.I78N		NM_004983.2	NP_004974.2	Q92806	IRK9_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 9	78					synaptic transmission	integral to membrane|plasma membrane	G-protein activated inward rectifier potassium channel activity|protein binding			biliary_tract(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|skin(2)	16	all_cancers(52;5.86e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TTCGGCGCCATCTGGTGGCTG	0.662000													33	14					0	0	1	0	0
WHAMMP3	0	broad.mit.edu	37	15	23205108	23205108	+	RNA	SNP	C	C	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr15:23205108C>T	ENST00000400153.2	-	0	746					NR_003521.1																						GTGGTTGCCACGGTAACTAAT	0.393000													3	16					0	0	1	0	0
LRPPRC	10128	broad.mit.edu	37	2	44145498	44145498	+	Missense_Mutation	SNP	T	T	C			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr2:44145498T>C	ENST00000260665.7	-	28	2993	c.2936A>G	c.(2935-2937)aAt>aGt	p.N979S		NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	979					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTGGATTTTATTCCAGACTGC	0.338000													25	31					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32802773	32802773	+	Missense_Mutation	SNP	T	T	C			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr13:32802773T>C	ENST00000380250.3	+	40	5883	c.5387T>C	c.(5386-5388)aTt>aCt	p.I1796T		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1796					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AACAAGCTCATTGAGTTTCTC	0.493000													38	44					0	0	1	0	0
IRF2BP1	26145	broad.mit.edu	37	19	46387368	46387368	+	Silent	SNP	G	G	A			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr19:46387368G>A	ENST00000302165.3	-	1	2008	c.1665C>T	c.(1663-1665)gtC>gtT	p.V555V		NM_015649.1	NP_056464.1	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein 1	555					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(1)|kidney(1)|lung(2)	4		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CGGAGGAGCCGACCAGCGGGC	0.632000													12	19					0	0	1	0	0
MOK	5891	broad.mit.edu	37	14	102718108	102718108	+	Silent	SNP	T	T	C			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr14:102718108T>C	ENST00000361847.2	-	6	627	c.396A>G	c.(394-396)gaA>gaG	p.E132E	MOK_ENST00000193029.6_5'UTR|MOK_ENST00000524214.1_Silent_p.E102E|MOK_ENST00000522874.1_Silent_p.E132E	NM_014226.1	NP_055041.1	Q9UQ07	MOK_HUMAN	MOK protein kinase	132	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding										TTAGTATATTTTCTGGTTTTA	0.308000													7	13					0	0	1	0	0
HUS1B	135458	broad.mit.edu	37	6	656774	656774	+	Silent	SNP	C	C	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr6:656774C>T	ENST00000380907.2	-	1	189	c.171G>A	c.(169-171)gaG>gaA	p.E57E	EXOC2_ENST00000230449.4_Intron|EXOC2_ENST00000448181.3_Intron	NM_148959.3	NP_683762.2	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint homolog b (S. pombe)	57										endometrium(3)|large_intestine(1)|lung(7)	11	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		CCTGCCGCACCTCGCACCACA	0.692000													9	5					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233296140	233296140	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr1:233296140C>T	ENST00000258229.8	-	19	3640	c.3406G>A	c.(3406-3408)Gtg>Atg	p.V1136M	PCNXL2_ENST00000488780.2_Missense_Mutation_p.V269M|PCNXL2_ENST00000520463.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1136						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				ACAAACCCCACGGCTCCAGCC	0.498000													24	39					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104640456	104640456	+	Missense_Mutation	SNP	T	T	C			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr4:104640456T>C	ENST00000304883.2	-	1	517	c.377A>G	c.(376-378)aAc>aGc	p.N126S		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	126						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GAAAGCCAGGTTCACAAGGAA	0.547000													23	40					0	0	1	0	0
NBPF15	284565	broad.mit.edu	37	1	148594434	148594434	+	Missense_Mutation	SNP	G	G	A	rs143361250	byFrequency	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr1:148594434G>A	ENST00000442702.2	+	21	2874	c.1807G>A	c.(1807-1809)Gtc>Atc	p.V603I	NBPF15_ENST00000369187.3_Missense_Mutation_p.V603I	NM_001170755.1	NP_001164226.1	Q8N660	NBPFF_HUMAN	neuroblastoma breakpoint family, member 15	603	NBPF 6.					cytoplasm				NS(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12	all_hematologic(923;0.032)					AGAGCCTGAAGTCTTACAGGA	0.458000													7	207					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								4	63					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49689757	49689757	+	Missense_Mutation	SNP	C	C	G			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr3:49689757C>G	ENST00000296452.4	+	5	2882	c.2768C>G	c.(2767-2769)aCc>aGc	p.T923S		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	923					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGCAGTGGGACCCTGCAGGGT	0.632000													23	31					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409427	105409427	+	Silent	SNP	G	G	A			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr14:105409427G>A	ENST00000333244.5	-	7	12480	c.12361C>T	c.(12361-12363)Ctg>Ttg	p.L4121L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4121						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTGTCGGCCAGGGACAGGTCC	0.587000													7	416					0	0	1	0	0
PEX5	5830	broad.mit.edu	37	12	7362742	7362742	+	Missense_Mutation	SNP	G	G	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr12:7362742G>T	ENST00000266563.5	+	15	1915	c.1732G>T	c.(1732-1734)Ggc>Tgc	p.G578C	PEX5_ENST00000434354.2_Missense_Mutation_p.G630C|PEX5_ENST00000266564.3_Missense_Mutation_p.G607C|PEX5_ENST00000420616.2_Missense_Mutation_p.G615C|PEX5_ENST00000412720.2_Missense_Mutation_p.G636C|PEX5_ENST00000455147.2_Missense_Mutation_p.G615C	NM_001131024.1	NP_001124496.1	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5	615					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)	21						GTCTATGTTAGGCCAGAGCGA	0.622000													49	48					3.76343e-11	4.29163e-11	1	1	0
WBP7	0	broad.mit.edu	37	19	36216141	36216141	+	Silent	SNP	C	C	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr19:36216141C>T	ENST00000222270.7	+	11	3549	c.3549C>T	c.(3547-3549)aaC>aaT	p.N1183N	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000420124.1_Silent_p.N1183N	NM_014727.1	NP_055542.1																					ATTTAGAGAACGTGTGGCTGA	0.592000													10	10					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104136068	104136068	+	Missense_Mutation	SNP	A	A	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr10:104136068A>T	ENST00000369983.3	+	31	4183	c.3923A>T	c.(3922-3924)aAt>aTt	p.N1308I		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	1308					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		TACCATCAGAATGACGTGAGC	0.582000													23	18					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr17:21730916G>T	ENST00000584755.1	+	2	615	c.218G>T	c.(217-219)cGg>cTg	p.R73L	UBBP4_ENST00000578713.1_Missense_Mutation_p.R73L|UBBP4_ENST00000584398.1_Intron|UBBP4_ENST00000583708.1_Intron														p.R73L(24)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCGGAGAGGTGGT	0.552000													4	84					0.150653	0.153007	1	1	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													5	85					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162462	90162462	+	RNA	SNP	A	A	G			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr16:90162462A>G	ENST00000564451.1	+	0	1815				TUBB8P7_ENST00000567960.1_RNA														p.T398T(1)									ACTGGTACACAGGCGAGGGCA	0.522000													5	111					0	0	1	0	0
ARAP1	116985	broad.mit.edu	37	11	72423246	72423246	+	Silent	SNP	C	C	G	rs149772953	byFrequency	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr11:72423246C>G	ENST00000359373.5	-	7	1868	c.1017G>C	c.(1015-1017)ccG>ccC	p.P339P	ARAP1_ENST00000426523.1_Silent_p.P94P|ARAP1_ENST00000393609.3_Silent_p.P339P|ARAP1_ENST00000455638.2_Silent_p.P339P|ARAP1_ENST00000429686.1_Silent_p.P94P|ARAP1_ENST00000334211.8_Silent_p.P94P|ARAP1_ENST00000393605.3_Silent_p.P99P			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	339	PH 1.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						CTCACCCCTGCGGTGGGTTCT	0.652000													3	20					0	0	1	0	0
UGT1A3	0	broad.mit.edu	37	2	234638622	234638622	+	Missense_Mutation	SNP	A	A	G			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr2:234638622A>G	ENST00000482026.1	+	1	869	c.850A>G	c.(850-852)Agg>Ggg	p.R284G	UGT1A6_ENST00000480628.1_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron	NM_019093.2	NP_061966.1														breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CTGTGCCAACAGGAAGCCACT	0.438000													7	156					0	0	1	0	0
CLDN14	23562	broad.mit.edu	37	21	37833680	37833680	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr21:37833680G>A	ENST00000399137.1	-	3	1180	c.314C>T	c.(313-315)aCg>aTg	p.T105M	AP000695.4_ENST00000428667.1_RNA|CLDN14_ENST00000399135.1_Missense_Mutation_p.T105M|CLDN14_ENST00000399136.1_Missense_Mutation_p.T105M|CLDN14_ENST00000399139.1_Missense_Mutation_p.T105M|CLDN14_ENST00000342108.2_Missense_Mutation_p.T105M|AP000695.6_ENST00000429588.1_RNA	NM_144492.2	NP_652763.1	O95500	CLD14_HUMAN	claudin 14	105					calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|lung(5)|skin(1)	7						GGCGCAGCGCGTGCACTTCAT	0.687000													35	40					0	0	1	0	0
HSPA8	3312	broad.mit.edu	37	11	122931955	122931955	+	Silent	SNP	G	G	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr11:122931955G>T	ENST00000534624.1	-	2	354	c.78C>A	c.(76-78)gtC>gtA	p.V26V	HSPA8_ENST00000453788.2_Silent_p.V26V|HSPA8_ENST00000533540.1_Silent_p.V26V|HSPA8_ENST00000532636.1_Silent_p.V26V|HSPA8_ENST00000227378.3_Silent_p.V26V|HSPA8_ENST00000526110.1_Silent_p.V26V	NM_006597.4	NP_006588.1	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8	26					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			breast(1)|central_nervous_system(7)|endometrium(1)|kidney(9)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	36		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CAATTATCTCGACTTTTCCGT	0.468000													3	32					6.4e-05	6.93333e-05	1	1	0
GUSBP1	0	broad.mit.edu	37	5	21491446	21491446	+	RNA	SNP	G	G	T	rs150396680	by1000genomes	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr5:21491446G>T	ENST00000607545.1	+	0	179					NR_027026.1																						TGAATTACCAGATCTCCGTCA	0.532000													4	42					1.5739e-10	1.76385e-10	1	1	0
MMP12	4321	broad.mit.edu	37	11	102736506	102736506	+	RNA	SNP	C	C	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr11:102736506C>T	ENST00000532855.1	-	0	1301							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TTAAAACTCACCTCCAATACT	0.383000													8	0					0	0	1	0	0
SDHAP1	0	broad.mit.edu	37	3	195717061	195717061	+	RNA	SNP	C	C	A			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr3:195717061C>A	ENST00000427841.1	-	0	89					NR_003264.2																						AGGGACTCACCGCCTTGGCCA	0.791000													12	12					0.00136819	0.00145791	1	1	0
ZNF619	285267	broad.mit.edu	37	3	40529513	40529513	+	Silent	SNP	G	G	A			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr3:40529513G>A	ENST00000447116.2	+	6	1939	c.1632G>A	c.(1630-1632)ctG>ctA	p.L544L	ZNF619_ENST00000432264.2_Silent_p.L504L|ZNF619_ENST00000429348.2_Silent_p.L504L|ZNF619_ENST00000520737.1_3'UTR|ZNF619_ENST00000314686.5_Silent_p.L488L|ZNF619_ENST00000456778.1_Silent_p.L460L|ZNF619_ENST00000522736.1_Silent_p.L495L|ZNF619_ENST00000521353.1_Silent_p.L544L	NM_001145082.2	NP_001138554.1	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619	544					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		TCTCTCCTCTGCCTCCCCAAC	0.547000													34	41					0	0	1	0	0
TCTN2	79867	broad.mit.edu	37	12	124179517	124179517	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr12:124179517C>T	ENST00000303372.5	+	10	1356	c.1228C>T	c.(1228-1230)Cag>Tag	p.Q410*	TCTN2_ENST00000426174.2_Nonsense_Mutation_p.Q409*	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	410					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		TAATGCCCACCAGAAAGGTAA	0.299000													29	27					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49175929	49175929	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr11:49175929C>T	ENST00000340334.7	-	17	2062	c.1694G>A	c.(1693-1695)cGa>cAa	p.R565Q	FOLH1_ENST00000343844.4_Missense_Mutation_p.R272Q|FOLH1_ENST00000256999.2_Missense_Mutation_p.R580Q|FOLH1_ENST00000533034.1_Missense_Mutation_p.R565Q|FOLH1_ENST00000356696.3_Missense_Mutation_p.R580Q	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	580	NAALADase.				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	CATCCCTCCTCGAACCTGGGC	0.408000													43	54					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97867947	97867947	+	Missense_Mutation	SNP	C	C	G	rs10203570	by1000genomes	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr2:97867947C>G	ENST00000420699.2	+	47	3110	c.2866C>G	c.(2866-2868)Cag>Gag	p.Q956E	ANKRD36_ENST00000461153.2_Missense_Mutation_p.Q956E	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	956										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						AGTGTCTTCTCAGAAACCACC	0.343000													7	60					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				32	54					0	0	1	0	0
ABCB6	10058	broad.mit.edu	37	2	220078577	220078577	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr2:220078577C>T	ENST00000265316.3	-	9	1865	c.1549G>A	c.(1549-1551)Gca>Aca	p.A517T	ABCB6_ENST00000439002.2_Missense_Mutation_p.A471T	NM_005689.2	NP_005680.1	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 6	517	ABC transmembrane type-1.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	34		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACAAAGTATGCGCAAAGCAGG	0.562000													5	397					0	0	1	0	0
USP53	54532	broad.mit.edu	37	4	120169968	120169968	+	Silent	SNP	T	T	C			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr4:120169968T>C	ENST00000450251.1	+	3	847	c.303T>C	c.(301-303)gcT>gcC	p.A101A	USP53_ENST00000274030.6_Silent_p.A101A			Q70EK8	UBP53_HUMAN	ubiquitin specific peptidase 53	101					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	27						TAAGGCATGCTCTTGCAGAAA	0.408000													57	57					0	0	1	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117431414	117431414	+	Silent	SNP	T	T	G			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr7:117431414T>G	ENST00000160373.3	-	4	1927	c.1836A>C	c.(1834-1836)ccA>ccC	p.P612P		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	612										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		ATGGTTTTGGTGGCAGCTGAG	0.552000													22	19					0	0	1	0	0
HERC2P2	0	broad.mit.edu	37	15	23283320	23283320	+	RNA	SNP	C	C	A	rs149049629	by1000genomes	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr15:23283320C>A	ENST00000560464.1	-	0	5097																											CAGCGTGTGCCTTTTCCTTCC	0.453000													13	65					4.3838e-07	4.82961e-07	1	1	0
RYR2	6262	broad.mit.edu	37	1	237753135	237753135	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr1:237753135G>A	ENST00000366574.2	+	30	3958	c.3641G>A	c.(3640-3642)aGg>aAg	p.R1214K	RYR2_ENST00000542537.1_Missense_Mutation_p.R1198K|RYR2_ENST00000360064.6_Missense_Mutation_p.R1212K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1214	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAAGTGGGTAGGATGAACTTT	0.388000													29	57					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39799059	39799060	+	Frame_Shift_Ins	INS	-	-	G			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr1:39799059_39799060insG	ENST00000564288.1	+	37	7576_7577	c.6799_6800insG	c.(6799-6801)ggafs	p.G2267fs	MACF1_ENST00000372915.3_Frame_Shift_Ins_p.G2272fs|MACF1_ENST00000289893.4_Frame_Shift_Ins_p.G707fs|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000567887.1_Frame_Shift_Ins_p.G2304fs|MACF1_ENST00000539005.1_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2272					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGATAGTGGCAGGGAAATTTTT	0.391													20	108	---	---	---	---					
NR1I3	0	broad.mit.edu	37	1	161202999	161203000	+	Frame_Shift_Ins	INS	-	-	G	rs139473535	by1000genomes	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr1:161202999_161203000insG	ENST00000367983.4	-	4	661_662	c.367_368insC	c.(367-369)ccafs	p.P123fs	NR1I3_ENST00000428574.2_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000511944.1_Intron|NR1I3_ENST00000506209.1_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000367980.2_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000367985.3_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000367979.2_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000367982.4_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000412844.2_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000442691.2_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000367984.4_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000508740.1_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000502985.1_Intron|NR1I3_ENST00000515621.1_Frame_Shift_Ins_p.P48fs|NR1I3_ENST00000515452.1_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000512372.1_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000511676.1_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000437437.2_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000511748.1_Intron|NR1I3_ENST00000367981.3_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000508387.1_Intron|NR1I3_ENST00000505005.1_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000504010.1_Frame_Shift_Ins_p.P94fs			Q14994	NR1I3_HUMAN	nuclear receptor subfamily 1, group I, member 3	123					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	15	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GCCCATGTGGCGGGTGTGGGCC	0.564													8	361	---	---	---	---					
CRIPAK	285464	broad.mit.edu	37	4	1389084	1389085	+	Frame_Shift_Del	DEL	CA	CA	-	rs71299249		TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr4:1389084_1389085delCA	ENST00000324803.4	+	1	3745_3746	c.785_786delCA	c.(784-786)tfs	p.S262fs		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	262					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CCCGCCTGCTCACACGTGCCCA	0.693													9	472	---	---	---	---					
PCDHB12	0	broad.mit.edu	37	5	140589694	140589695	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr5:140589694_140589695delAG	ENST00000239450.2	+	1	1404_1405	c.1215_1216delAG	c.(1213-1218)acagfs	p.TE405fs	PCDHB12_ENST00000541609.1_Frame_Shift_Del_p.TE68fs	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		405	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTTGGAAACAGAGAGACCGCT	0.495													7	102	---	---	---	---					
LARP1	23367	broad.mit.edu	37	5	154173389	154173390	+	Frame_Shift_Ins	INS	-	-	C			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr5:154173389_154173390insC	ENST00000336314.4	+	6	691_692	c.667_668insC	c.(667-669)cccfs	p.P223fs		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	300							protein binding|RNA binding	p.T303fs*19(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CGTGCCCGTGGCCCCCCCCACC	0.644													7	318	---	---	---	---					
KIAA1009	22832	broad.mit.edu	37	6	84896233	84896233	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr6:84896233delA	ENST00000403245.3	-	12	1332	c.1218delT	c.(1216-1218)ttfs	p.F406fs	KIAA1009_ENST00000461137.1_5'UTR|KIAA1009_ENST00000257766.4_Frame_Shift_Del_p.F330fs	NM_014895.2	NP_055710.2	Q5TB80	QN1_HUMAN	KIAA1009	406					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		CATTTTTGTCAAAAAAAAGGT	0.358													7	128	---	---	---	---					
STAG3L2	0	broad.mit.edu	37	7	74300804	74300804	+	RNA	DEL	A	A	-			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr7:74300804delA	ENST00000423186.1	-	0	499							P0CL84	ST3L2_HUMAN								nucleus	binding			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|pancreas(1)	5						CTTCATACTTAAAAAAAAAAA	0.458													2	4	---	---	---	---					
TG	7038	broad.mit.edu	37	8	133935598	133935600	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr8:133935598_133935600delAGA	ENST00000220616.4	+	22	4584_4586	c.4544_4546delAGA	c.(4543-4548)cgg>c	p.QR1515del	TG_ENST00000377869.1_Intron|TG_ENST00000542445.1_5'UTR	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1515	Thyroglobulin type-1 11.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ACTGACTGTCAGAGGAACGAAGC	0.562													22	44	---	---	---	---					
PRB2	653247	broad.mit.edu	37	12	11546506	11546508	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr12:11546506_11546508delTTG	ENST00000389362.4	-	3	539_541	c.504_506delCAA	c.(502-507)aag>aa	p.NK168del	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			ACTTCGGGACTTGTTGTCTCCTT	0.596													16	664	---	---	---	---					
KRT1	3848	broad.mit.edu	37	12	53069236	53069256	+	In_Frame_Del	DEL	TAGCTGCTACCTCCGGAGCCA	TAGCTGCTACCTCCGGAGCCA	-	rs66529359	by1000genomes	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr12:53069236_53069256delTAGCTGCTACCTCCGGAGCCA	ENST00000252244.3	-	9	1714_1734	c.1656_1676delTGGCTCCGGAGGTAGCAGCTA	c.(1654-1677)tac>ta	p.YGSGGSSY552del		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	552	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding	p.S557_G563delSSYGSGG(3)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						tccggagccgtagctgctacctccggagccatagctgccac	0.688													5	7	---	---	---	---					
EP400	57634	broad.mit.edu	37	12	132547093	132547094	+	In_Frame_Ins	INS	-	-	CAG	rs113304321	by1000genomes	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr12:132547093_132547094insCAG	ENST00000333577.4	+	48	8398_8399	c.8289_8290insCAG	c.(8287-8292)caagca>caCAGagca	p.2763_2763Q>HR	EP400_ENST00000332482.4_In_Frame_Ins_p.2690_2690Q>HR|EP400_ENST00000389562.2_In_Frame_Ins_p.2726_2726Q>HR|EP400_ENST00000389561.2_In_Frame_Ins_p.2727_2727Q>HR|EP400_ENST00000330386.6_In_Frame_Ins_p.2646_2646Q>HR			Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2726Q(9)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagca	0.564													8	81	---	---	---	---					
TEP1	7011	broad.mit.edu	37	14	20852647	20852647	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr14:20852647delC	ENST00000262715.5	-	23	3282	c.3242delG	c.(3241-3243)gtfs	p.G1081fs	TEP1_ENST00000556935.1_Frame_Shift_Del_p.G973fs	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1081					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding	p.V1082fs*47(1)		NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGCTGCCACACCCCCCCACTC	0.587													7	366	---	---	---	---					
TRAV24	0	broad.mit.edu	37	14	22573824	22573825	+	RNA	INS	-	-	A	rs112427980	by1000genomes	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr14:22573824_22573825insA	ENST00000390453.1	+	0	55																											TGACTCTTTTTTAAAAAAACAG	0.450													10	9	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74394379	74394380	+	RNA	INS	-	-	A	rs142790741	by1000genomes	TCGA-DE-A4MD-01A-11D-A257-08	TCGA-DE-A4MD-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128eeeac-803e-489e-bd6d-fa9972824ded	59a49a5a-e5fc-4684-b043-d5992e423463	g.chr16:74394379_74394380insA	ENST00000429810.2	-	0	435																											TAGTCATCCTTAAACAAAATTC	0.347													2	4	---	---	---	---