Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													5	56					0	0	0.000602	0	0
APBB1	322	broad.mit.edu	37	11	6422254	6422254	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr11:6422254T>C	ENST00000389906.2	-	11	1736	c.1637A>G	c.(1636-1638)tAt>tGt	p.Y546C	APBB1_ENST00000299402.6_Missense_Mutation_p.Y544C|APBB1_ENST00000524626.1_5'UTR|APBB1_ENST00000311051.3_Missense_Mutation_p.Y544C|APBB1_ENST00000530885.1_Missense_Mutation_p.Y324C	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	546	PID 2.				apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CCCCAGGTAATAGACTTGGAA	0.498000													156	177					0	0	0.003610	0	0
ZNF733P	0	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	19					0	0	0.000602	0	0
MED16	10025	broad.mit.edu	37	19	889754	889754	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr19:889754C>T	ENST00000312090.6	-	4	481	c.331G>A	c.(331-333)Gcg>Acg	p.A111T	MED16_ENST00000395808.3_Missense_Mutation_p.A111T|MED16_ENST00000269814.4_Missense_Mutation_p.A111T|MED16_ENST00000325464.1_Missense_Mutation_p.A111T|MED16_ENST00000589119.1_Missense_Mutation_p.A111T|MED16_ENST00000606828.1_Intron			Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	111					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTGGTCCGCCATGCTCCAG	0.617000													5	12					0	0	0.001168	0	0
RGL4	266747	broad.mit.edu	37	22	24034592	24034592	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr22:24034592T>C	ENST00000290691.5	+	2	1420	c.250T>C	c.(250-252)Tca>Cca	p.S84P	GUSBP11_ENST00000417194.1_RNA|RGL4_ENST00000401461.1_5'UTR	NM_153615.1	NP_705843.1	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation stimulator-like 4	84					small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(3)	15						CCCGCAACGGTCATCTTTCCG	0.542000													4	171					0	0	0.000248	0	0
PLA1A	51365	broad.mit.edu	37	3	119336952	119336952	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr3:119336952C>T	ENST00000273371.4	+	7	913	c.841C>T	c.(841-843)Ccc>Tcc	p.P281S	PLA1A_ENST00000494440.1_Missense_Mutation_p.P265S|PLA1A_ENST00000488919.1_Missense_Mutation_p.P108S|PLA1A_ENST00000495992.1_Missense_Mutation_p.P265S	NM_015900.3	NP_056984.1	Q53H76	PLA1A_HUMAN	phospholipase A1 member A	281					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GATGGCCTTTCCCTGTGCCAG	0.498000													26	318					0	0	0.005443	0	0
SPIDR	23514	broad.mit.edu	37	8	48625364	48625364	+	Silent	SNP	T	T	C			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr8:48625364T>C	ENST00000297423.4	+	15	2502	c.2118T>C	c.(2116-2118)tcT>tcC	p.S706S	SPIDR_ENST00000541342.1_Silent_p.S636S|SPIDR_ENST00000521214.1_3'UTR|SPIDR_ENST00000517693.1_Silent_p.S181S|SPIDR_ENST00000518074.1_Silent_p.S646S	NM_001080394.2	NP_001073863.1			scaffolding protein involved in DNA repair																		TGCTGGGCTCTGAAGTCCTGG	0.597000													3	101					0	0	0.000248	0	0
PHF7	51533	broad.mit.edu	37	3	52454958	52454958	+	Silent	SNP	A	A	G			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr3:52454958A>G	ENST00000327906.3	+	7	1113	c.453A>G	c.(451-453)caA>caG	p.Q151Q	PHF7_ENST00000347025.2_Silent_p.Q151Q|PHF7_ENST00000478707.1_Silent_p.Q151Q	NM_016483.4	NP_057567.3	Q9BWX1	PHF7_HUMAN	PHD finger protein 7	151						nucleus	zinc ion binding			breast(2)|large_intestine(4)|lung(3)	9				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		AGAACATCCAACATGGGCATG	0.468000													44	61					0	0	0.002222	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					5	69					0	0	0.000978	0	0
ZNF700	90592	broad.mit.edu	37	19	12059975	12059975	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr19:12059975C>A	ENST00000482090.1	+	3	1500	c.1082C>A	c.(1081-1083)aCa>aAa	p.T361K	ZNF763_ENST00000590798.1_Intron|CTD-2006C1.12_ENST00000586394.1_RNA|ZNF763_ENST00000538752.1_Intron|ZNF700_ENST00000254321.5_Missense_Mutation_p.T379K|ZNF763_ENST00000591944.1_Intron			Q9H0M5	ZN700_HUMAN	zinc finger protein 700	379					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		ZNF700/MAST1_ENST00000251472(2)	breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	33						TCATTTCAAACACATGAAAAA	0.353000													3	64					0.004672	0.00563862	0.004672	1	0
FAM179B	23116	broad.mit.edu	37	14	45542645	45542645	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr14:45542645T>C	ENST00000361462.2	+	20	5386	c.5203T>C	c.(5203-5205)Tca>Cca	p.S1735P	FAM179B_ENST00000382233.2_3'UTR|FAM179B_ENST00000361577.3_Missense_Mutation_p.S1682P			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	1682							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						AGCTAAATTATCAAAAGCACT	0.408000													9	44					0	0	0.008291	0	0
EXT1	2131	broad.mit.edu	37	8	118817027	118817027	+	Silent	SNP	A	A	G			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr8:118817027A>G	ENST00000378204.2	-	10	2795	c.1989T>C	c.(1987-1989)gcT>gcC	p.A663A		NM_000127.2	NP_000118.2	Q16394	EXT1_HUMAN	exostosin glycosyltransferase 1	663					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(12)|lung(10)|ovary(3)|prostate(1)|stomach(1)|urinary_tract(2)	38	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			ATTTTGTCACAGCAGACACCA	0.468000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Langer-Giedion syndrome;Hereditary Multiple Exostoses				17	69					0	0	0.004990	0	0
USP51	158880	broad.mit.edu	37	X	55514742	55514742	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chrX:55514742G>C	ENST00000500968.3	-	2	713	c.631C>G	c.(631-633)Ctg>Gtg	p.L211V	USP51_ENST00000586165.1_Intron	NM_201286.3	NP_958443.1	Q70EK9	UBP51_HUMAN	ubiquitin specific peptidase 51	211					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30						ATCAACCTCAGGTTCTTCTGC	0.502000													6	36					0	0	0.001168	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000348295.3_Silent_p.S343S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	71					0	0	0.000978	0	0
RPL22L1	200916	broad.mit.edu	37	3	170586127	170586127	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr3:170586127G>T	ENST00000295830.8	-	2	377	c.62C>A	c.(61-63)aCt>aAt	p.T21N	RPL22L1_ENST00000463836.1_Missense_Mutation_p.T20N	NM_001099645.1	NP_001093115.1	Q6P5R6	RL22L_HUMAN	ribosomal protein L22-like 1	21					translation	ribosome	structural constituent of ribosome			kidney(2)|large_intestine(1)|upper_aerodigestive_tract(1)	4	all_cancers(22;1.96e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.137)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			TACTGGATGAGTAAGGTCCAA	0.313000													19	25					0.000229342	0.000286677	0.001882	1	0
PIK3C2A	5286	broad.mit.edu	37	11	17190952	17190952	+	Missense_Mutation	SNP	T	T	G			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr11:17190952T>G	ENST00000265970.7	-	1	336	c.337A>C	c.(337-339)Aaa>Caa	p.K113Q	PIK3C2A_ENST00000540361.1_Intron|PIK3C2A_ENST00000531428.1_Intron	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	113	Interaction with clathrin.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	ACAGGTGTTTTTTTAGTCTCG	0.403000													12	133					0	0	0.001855	0	0
PLD5	200150	broad.mit.edu	37	1	242428743	242428743	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr1:242428743C>T	ENST00000442594.2	-	5	736	c.227G>A	c.(226-228)cGt>cAt	p.R76H	PLD5_ENST00000536534.1_Missense_Mutation_p.R168H|PLD5_ENST00000427495.1_Missense_Mutation_p.R106H	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	168						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TTCAAAAAGACGTTGACCCTG	0.313000													19	33					0	0	0.006122	0	0
NBR1	4077	broad.mit.edu	37	17	41342634	41342634	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr17:41342634C>T	ENST00000422280.1	+	9	1163	c.704C>T	c.(703-705)cCa>cTa	p.P235L	NBR1_ENST00000341165.6_Missense_Mutation_p.P235L|NBR1_ENST00000590996.1_Missense_Mutation_p.P235L|NBR1_ENST00000589872.1_Missense_Mutation_p.P235L|NBR1_ENST00000542611.1_Missense_Mutation_p.P214L|NBR1_ENST00000389312.4_Missense_Mutation_p.P235L	NM_031858.2	NP_114064.1	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	235					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	24		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		AGCCTATGCCCATCCTACAAT	0.483000													4	10					0	0	0.000248	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104224043	104224043	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr14:104224043T>C	ENST00000202556.9	-	5	682	c.400A>G	c.(400-402)Atg>Gtg	p.M134V		NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	134	Gln-rich.				apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				CTAGCTGCCATATCTTGGAGC	0.388000													4	90					0	0	0.000248	0	0
LOX	4015	broad.mit.edu	37	5	121409788	121409788	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr5:121409788G>A	ENST00000231004.4	-	4	1254	c.955C>T	c.(955-957)Cac>Tac	p.H319Y	SRFBP1_ENST00000504881.1_Intron|LOX_ENST00000513319.1_5'UTR	NM_001178102.1|NM_002317.5	NP_001171573.1|NP_002308.2	P28300	LYOX_HUMAN	lysyl oxidase	319	Lysyl-oxidase like.				protein modification process	extracellular space	copper ion binding|protein-lysine 6-oxidase activity			endometrium(1)|lung(6)|prostate(1)	8		all_cancers(142;0.0124)|Prostate(80;0.0322)|Ovarian(225;0.0814)|Breast(839;0.143)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;2.14e-11)|OV - Ovarian serous cystadenocarcinoma(64;7.87e-10)|all cancers(49;2.49e-09)|COAD - Colon adenocarcinoma(49;0.02)		CTTGCTTTGTGGCCTTCAGCC	0.468000													4	123					0	0	0.000248	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				32	29					0	0	0.003271	0	0
PRPF8	10594	broad.mit.edu	37	17	1564570	1564570	+	Missense_Mutation	SNP	A	A	C			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr17:1564570A>C	ENST00000572621.1	-	26	4598	c.4333T>G	c.(4333-4335)Tat>Gat	p.Y1445D	PRPF8_ENST00000304992.6_Missense_Mutation_p.Y1445D			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1445						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		CATACCTGATACTGCTTAAAG	0.512000													23	100					0	0	0.002780	0	0
SPAM1	0	broad.mit.edu	37	7	123599696	123599696	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr7:123599696C>G	ENST00000340011.5	+	5	1560	c.1203C>G	c.(1201-1203)aaC>aaG	p.N401K	SPAM1_ENST00000439500.1_Missense_Mutation_p.N401K|SPAM1_ENST00000223028.7_Missense_Mutation_p.N401K|SPAM1_ENST00000402183.2_Missense_Mutation_p.N401K|SPAM1_ENST00000460182.1_Missense_Mutation_p.N401K	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	401					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	TTCACCTCAACCCAGATAATT	0.403000													9	69					0	0	0.000978	0	0
TTC40	54777	broad.mit.edu	37	10	134743170	134743170	+	Silent	SNP	C	C	T			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr10:134743170C>T	ENST00000368585.3	-	9	1343	c.1005G>A	c.(1003-1005)gcG>gcA	p.A335A	TTC40_ENST00000368586.5_Intron|TTC40_ENST00000368582.2_Intron			Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	0										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						CGGTGAGCAGCGCCTCATCCC	0.557000													12	85					0	0	0.001368	0	0
ARSE	415	broad.mit.edu	37	X	2864076	2864076	+	Silent	SNP	C	C	A			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chrX:2864076C>A	ENST00000545496.1	-	8	1320	c.1029G>T	c.(1027-1029)ctG>ctT	p.L343L	ARSE_ENST00000381134.3_Silent_p.L318L|ARSE_ENST00000540563.1_Silent_p.L273L			P51690	ARSE_HUMAN	arylsulfatase E (chondrodysplasia punctata 1)	318					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGTCCCCATACAGCCCGTGGA	0.498000													44	63					2.77807e-22	3.6012e-22	0.003214	1	0
MMP17	4326	broad.mit.edu	37	12	132334395	132334395	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr12:132334395C>T	ENST00000360564.1	+	9	1355	c.1253C>T	c.(1252-1254)cCg>cTg	p.P418L	MMP17_ENST00000535004.1_Intron|MMP17_ENST00000535291.1_Missense_Mutation_p.P334L	NM_016155.4	NP_057239.4	Q9ULZ9	MMP17_HUMAN	matrix metallopeptidase 17 (membrane-inserted)	418	Hemopexin-like 2.				proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)	5	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		GAAGGATACCCGCGCCCCGTC	0.617000													5	80					0	0	0.001168	0	0
ITGA3	3675	broad.mit.edu	37	17	48156258	48156258	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr17:48156258G>A	ENST00000320031.8	+	19	2698	c.2368G>A	c.(2368-2370)Gat>Aat	p.D790N	ITGA3_ENST00000007722.7_Missense_Mutation_p.D790N	NM_002204.2|NM_005501.2	NP_002195.1|NP_005492.1	P26006	ITA3_HUMAN	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	790					blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	31						AACTGTGGAGGATGTAGGAAG	0.517000													42	71					0	0	0.006999	0	0
ODF1	4956	broad.mit.edu	37	8	103572989	103573015	+	In_Frame_Del	DEL	CCCCTGCAGCCCCTGCAGCCCCTGCAA	CCCCTGCAGCCCCTGCAGCCCCTGCAA	-	rs3018444	byFrequency	TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr8:103572989_103573015delCCCCTGCAGCCCCTGCAGCCCCTGCAA	ENST00000285402.3	+	2	786_812	c.630_656delCCCCTGCAGCCCCTGCAGCCCCTGCAA	c.(628-657)agc>ag	p.SPCSPCSPCN210del	ODF1_ENST00000518835.1_Splice_Site_p.SPCSPCSPCN3_splice	NM_024410.3	NP_077721.2	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	210	C-X-P repeat region.				cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity	p.C218_P226delCNPCSPCNP(1)|p.P217P(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			CTCCTtgcagcccctgcagcccctgcagcccctgcaacccctgcagc	0.555													8	43	---	---	---	---					
CORO1B	57175	broad.mit.edu	37	11	67206198	67206199	+	Frame_Shift_Ins	INS	-	-	G	rs141781443	by1000genomes	TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr11:67206198_67206199insG	ENST00000393893.1	-	11	1390_1391	c.1287_1288insC	c.(1285-1290)cccctcfs	p.L430fs	CORO1B_ENST00000539724.1_5'UTR|CORO1B_ENST00000341356.5_Frame_Shift_Ins_p.L430fs	NM_001018070.2	NP_001018080.1	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	430					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	13			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			GTGGTGGAGGCGGGGGCCCCTA	0.718													3	3	---	---	---	---					
DHH	50846	broad.mit.edu	37	12	49485004	49485005	+	In_Frame_Ins	INS	-	-	GTTGCG			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr12:49485004_49485005insGTTGCG	ENST00000266991.2	-	2	777_778	c.471_472insCGCAAC	c.(469-474)aaagta>aaCGCAACagta	p.157_157K>NAT	RP11-386G11.8_ENST00000553174.1_RNA	NM_021044.2	NP_066382.1	O43323	DHH_HUMAN	desert hedgehog	157					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			breast(1)|large_intestine(3)|lung(4)	8						AACCCATACTTGTTGCGGTCGC	0.609													30	84	---	---	---	---					
PPM1D	8493	broad.mit.edu	37	17	58740498	58740499	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr17:58740498_58740499insA	ENST00000305921.3	+	6	1635_1636	c.1403_1404insA	c.(1402-1404)taafs	p.*468fs		NM_003620.3	NP_003611.1	O15297	PPM1D_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1D	468					negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			GTCATACCCTCAAAAGATCCAG	0.421											OREG0031485	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	11	94	---	---	---	---					
CYP4F8	11283	broad.mit.edu	37	19	15726721	15726722	+	RNA	INS	-	-	ACTCACTCATTCCTCTGATC	rs148338083	by1000genomes	TCGA-DJ-A1QE-01A-21D-A14W-08	TCGA-DJ-A1QE-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f45d79-f4d0-4652-8cb5-08e2bbac043d	7f5fa0d9-7c50-432d-852e-de290831bc52	g.chr19:15726721_15726722insACTCACTCATTCCTCTGATC	ENST00000441682.2	+	0	262							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						ACGGCAGAGAAactcactcatt	0.559													3	4	---	---	---	---