Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SF1	7536	broad.mit.edu	37	11	64535651	64535651	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr11:64535651G>A	ENST00000377390.3	-	9	1332	c.995C>T	c.(994-996)aCc>aTc	p.T332I	SF1_ENST00000489544.1_5'UTR|SF1_ENST00000377387.1_Missense_Mutation_p.T457I|SF1_ENST00000334944.5_Missense_Mutation_p.T332I|SF1_ENST00000433274.2_Missense_Mutation_p.T306I|SF1_ENST00000377394.3_Missense_Mutation_p.T332I|SF1_ENST00000422298.2_Missense_Mutation_p.T217I|SF1_ENST00000227503.9_Missense_Mutation_p.T332I	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	332	Pro-rich.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						AGGCCCAGAGGTGGAGCCCAC	0.607000											OREG0004010|OREG0021062	type=REGULATORY REGION|Gene=LOC476031|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay|type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	70					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128380909	128380909	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr2:128380909G>T	ENST00000389524.4	+	28	3753	c.3700G>T	c.(3700-3702)Gac>Tac	p.D1234Y	MYO7B_ENST00000428314.1_Missense_Mutation_p.D1234Y|MYO7B_ENST00000409816.2_Missense_Mutation_p.D1234Y|MYO7B_ENST00000409090.1_Missense_Mutation_p.D87Y			Q6PIF6	MYO7B_HUMAN	myosin VIIB	1234	FERM 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GGGCCTCAGCGACCACCTGGG	0.632000													8	30					3.09899e-07	3.3469e-07	1	1	0
RP11-24M17.5	0	broad.mit.edu	37	15	76067987	76067987	+	RNA	SNP	A	A	G	rs34243492	by1000genomes	TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr15:76067987A>G	ENST00000395215.3	+	0	94																											GAAGAAACTCAACAGAGTAAA	0.537000													3	55					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161926	90161926	+	RNA	SNP	T	T	C	rs8061283	by1000genomes	TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr16:90161926T>C	ENST00000564451.1	+	0	1279				TUBB8P7_ENST00000567960.1_RNA														p.I221T(3)									CCCACACCCATCTATGGTGAC	0.527000													3	31					0	0	1	0	0
L1CAM	3897	broad.mit.edu	37	X	153130322	153130322	+	Silent	SNP	G	G	A	rs149420127		TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chrX:153130322G>A	ENST00000370060.1	-	23	3189	c.3000C>T	c.(2998-3000)ggC>ggT	p.G1000G	L1CAM_ENST00000361981.3_Silent_p.G995G|L1CAM_ENST00000361699.4_Silent_p.G1000G|L1CAM_ENST00000370055.1_Silent_p.G995G|L1CAM_ENST00000543994.1_Silent_p.G1002G|L1CAM_ENST00000538883.1_Silent_p.G1002G|L1CAM_ENST00000370057.3_Silent_p.G1000G	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	1000	Fibronectin type-III 4.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane		p.G1000G(1)		NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTTCACCAGGGCCCTCTTTGG	0.632000													6	261					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47681877	47681877	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr6:47681877G>T	ENST00000283303.2	+	6	1154	c.896G>T	c.(895-897)gGg>gTg	p.G299V	GPR115_ENST00000371220.1_Missense_Mutation_p.G356V|GPR115_ENST00000327753.3_Missense_Mutation_p.G299V	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	299					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						CCAACCTTGGGGGCTATCCTG	0.468000													22	26					1.50039e-11	1.76133e-11	1	1	0
ARID1A	8289	broad.mit.edu	37	1	27099905	27099905	+	Translation_Start_Site	SNP	C	C	A			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr1:27099905C>A	ENST00000540690.1	+	0	93				ARID1A_ENST00000374152.2_Missense_Mutation_p.R879S|ARID1A_ENST00000457599.2_Missense_Mutation_p.R1262S|ARID1A_ENST00000324856.7_Missense_Mutation_p.R1262S			O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)						androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCCCTACAGTCGTGCTGCCGG	0.592000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								3	64					1	1	1	1	0
FRG1B	0	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													4	73					0	0	1	0	0
STATH	6779	broad.mit.edu	37	4	70865527	70865527	+	Splice_Site	SNP	G	G	A			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr4:70865527G>A	ENST00000246895.4	+	4	213		c.e4+1		STATH_ENST00000381060.2_Intron	NM_003154.2	NP_003145.1	P02808	STAT_HUMAN	statherin						biomineral tissue development|negative regulation of bone mineralization|ossification|saliva secretion	extracellular region	extracellular matrix constituent, lubricant activity|hydroxyapatite binding|protein binding|structural constituent of tooth enamel			lung(2)|skin(1)	3						AAGATTCGGTGTAAGTGTTCT	0.299000													16	29					0	0	1	0	0
XRCC3	7517	broad.mit.edu	37	14	104169529	104169529	+	Missense_Mutation	SNP	A	A	T			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr14:104169529A>T	ENST00000553264.1	-	5	1338	c.542T>A	c.(541-543)aTc>aAc	p.I181N	XRCC3_ENST00000554913.1_Missense_Mutation_p.I181N|XRCC3_ENST00000555055.1_Missense_Mutation_p.I181N|XRCC3_ENST00000555832.1_5'UTR|XRCC3_ENST00000445556.1_Missense_Mutation_p.I181N|XRCC3_ENST00000352127.7_Missense_Mutation_p.I181N|XRCC3_ENST00000554974.1_Intron			O43542	XRCC3_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 3	181					DNA recombination|DNA repair	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity			endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)	4		Melanoma(154;0.155)|all_epithelial(191;0.19)		Epithelial(152;0.239)		CACGTGCTCGATGAAGATCTG	0.612000								Direct reversal of damage;Homologous recombination					4	5					0	0	1	0	0
NOC2L	26155	broad.mit.edu	37	1	887945	887945	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr1:887945G>T	ENST00000327044.6	-	10	1087	c.1038C>A	c.(1036-1038)ttC>ttA	p.F346L		NM_015658.3	NP_056473.2	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog (S. cerevisiae)	346						nucleolus	protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	16	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		CAGGCGAGGTGAACTTGCAGT	0.617000													4	99					0.00909568	0.00944551	1	1	0
SIGLEC8	27181	broad.mit.edu	37	19	51960834	51960834	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr19:51960834C>T	ENST00000321424.3	-	2	680	c.614G>A	c.(613-615)cGc>cAc	p.R205H	SIGLEC8_ENST00000340550.5_Intron|SIGLEC8_ENST00000430817.1_Intron	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	205	Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CACTGAGGAGCGGGCAGTAGT	0.652000													21	49					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96788936	96788936	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr14:96788936G>C	ENST00000359933.4	-	17	3570	c.2677C>G	c.(2677-2679)Cta>Gta	p.L893V		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	893										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GGTCTTCTTAGATCACAAACA	0.398000													9	36					0	0	1	0	0
WDTC1	23038	broad.mit.edu	37	1	27623608	27623608	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr1:27623608G>C	ENST00000319394.3	+	11	1554	c.1019G>C	c.(1018-1020)aGc>aCc	p.S340T	WDTC1_ENST00000361771.3_Missense_Mutation_p.S339T	NM_001276252.1|NM_015023.3	NP_001263181.1|NP_055838.2	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	340							protein binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	21		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		CACCTTCATAGCAATGGCTTC	0.557000											OREG0013279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	19					0	0	1	0	0
SIRPG	55423	broad.mit.edu	37	20	1629760	1629760	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr20:1629760C>T	ENST00000381580.1	-	2	448	c.269G>A	c.(268-270)cGa>cAa	p.R90Q	SIRPG_ENST00000344103.4_Missense_Mutation_p.R123Q|SIRPG_ENST00000381583.2_Missense_Mutation_p.R123Q|SIRPG_ENST00000216927.4_Missense_Mutation_p.R123Q|SIRPG_ENST00000303415.3_Missense_Mutation_p.R123Q			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	123	Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						GCTCCCTTTTCGAAACTTCAC	0.498000													6	142					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr19:58385762C>G	ENST00000435989.2	-	3	1230	c.996G>C	c.(994-996)tcG>tcC	p.S332S	ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597832.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.S332S(2)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						ATTTGCTAAACGATTTCCCAC	0.358000													2	6					0	0	1	0	0
PRPF38A	84950	broad.mit.edu	37	1	52874249	52874249	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr1:52874249G>A	ENST00000257181.9	+	3	485	c.299G>A	c.(298-300)cGc>cAc	p.R100H	PRPF38A_ENST00000474048.1_Intron	NM_032864.3	NP_116253.2	Q8NAV1	PR38A_HUMAN	pre-mRNA processing factor 38A	100					mRNA processing|RNA splicing	spliceosomal complex				cervix(2)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|stomach(1)	9						AGGTATGTCCGCATGCTGGGG	0.443000													4	89					0	0	1	0	0
ARSF	416	broad.mit.edu	37	X	3030306	3030306	+	Silent	SNP	C	C	T			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chrX:3030306C>T	ENST00000381127.1	+	11	1703	c.1482C>T	c.(1480-1482)ttC>ttT	p.F494F	ARSF_ENST00000359361.2_Silent_p.F494F|ARSF_ENST00000537104.1_Silent_p.F494F	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	494						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCAGATGTTTCGGAGAACAGG	0.572000													5	152					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057069	9057069	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr19:9057069G>A	ENST00000397910.4	-	3	30580	c.30377C>T	c.(30376-30378)cCa>cTa	p.P10126L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10128	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGCCTTGGATGGCTCCGAGTG	0.463000													6	62					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				31	63					0	0	1	0	0
CIDECP	0	broad.mit.edu	37	3	10065426	10065426	+	RNA	SNP	C	C	T	rs6803517	by1000genomes	TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr3:10065426C>T	ENST00000432401.1	-	0	322																											GTGGGTGCCTCGTCCCCTGCA	0.502000													3	57					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40712010	40712010	+	Silent	SNP	C	C	G			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr22:40712010C>G	ENST00000454349.2	+	21	5179	c.4968C>G	c.(4966-4968)acC>acG	p.T1656T	TNRC6B_ENST00000335727.8_Silent_p.T1546T|TNRC6B_ENST00000301923.9_Silent_p.T852T|TNRC6B_ENST00000402203.1_Silent_p.T852T	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1656	RRM.				gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						ACAATCTCACCCCACAGGTAA	0.453000													6	31					0	0	1	0	0
DLX2	1746	broad.mit.edu	37	2	172967129	172967131	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr2:172967129_172967131delGCT	ENST00000234198.4	-	1	497_499	c.136_138delAGC	c.(136-138)del	p.S46del	DLX2_ENST00000466293.2_In_Frame_Del_p.S46del	NM_004405.3	NP_004396.1	Q07687	DLX2_HUMAN	distal-less homeobox 2	46	Poly-Ser.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(2)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(117;0.216)			GCTTGTGGAGgctgctgctgctg	0.739													2	4	---	---	---	---					
CACNA1B	774	broad.mit.edu	37	9	141015112	141015112	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DJ-A3V4-01A-11D-A22Z-08	TCGA-DJ-A3V4-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ccdc15b4-f2dc-4dd6-a5be-a20ae9c91482	11790be6-dc18-46cf-80b9-071c1a1a611c	g.chr9:141015112delC	ENST00000277549.5	+	46	6419	c.3850delC	c.(3850-3852)ccfs	p.P1285fs	CACNA1B_ENST00000277551.2_Frame_Shift_Del_p.P2091fs|CACNA1B_ENST00000371355.4_Frame_Shift_Del_p.P2092fs|CACNA1B_ENST00000371357.1_Frame_Shift_Del_p.P2090fs|CACNA1B_ENST00000371363.1_Frame_Shift_Del_p.P2089fs|CACNA1B_ENST00000371372.1_Frame_Shift_Del_p.P2091fs			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	2091					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GCCGGGGCTGCCCCCGGGAGA	0.731													2	4	---	---	---	---