Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DENND4B	9909	broad.mit.edu	37	1	153907309	153907309	+	Silent	SNP	C	C	T			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr1:153907309C>T	ENST00000361217.4	-	18	3118	c.2700G>A	c.(2698-2700)caG>caA	p.Q900Q		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	900	Gln-rich.							p.Q788Q(1)|p.Q900Q(1)		NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgttgctgctgctgct	0.642000													4	77					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38854566	38854566	+	Splice_Site	SNP	G	G	C			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr6:38854566G>C	ENST00000359357.3	+	55	7862		c.e55-1		DNAH8_ENST00000449981.2_Splice_Site|DNAH8_ENST00000441566.1_Splice_Site					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGAAATTTCAGATAACTAATG	0.338000													7	90					0	0	1	0	0
UBR3	130507	broad.mit.edu	37	2	170843170	170843170	+	Missense_Mutation	SNP	A	A	T			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr2:170843170A>T	ENST00000272793.5	+	25	3700	c.3650A>T	c.(3649-3651)gAt>gTt	p.D1217V	UBR3_ENST00000418381.1_Missense_Mutation_p.D1217V|UBR3_ENST00000392631.1_Missense_Mutation_p.D38V			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1217					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						CCTGAGAATGATATTCCTATG	0.418000													5	54					0	0	1	0	0
THBS3	7059	broad.mit.edu	37	1	155168008	155168008	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr1:155168008T>C	ENST00000368378.3	-	18	2098	c.2078A>G	c.(2077-2079)aAt>aGt	p.N693S	THBS3_ENST00000487250.1_5'UTR|RP11-263K19.4_ENST00000454348.1_RNA|THBS3_ENST00000457183.2_Missense_Mutation_p.N573S|THBS3_ENST00000428962.2_3'UTR|RP11-263K19.4_ENST00000447623.1_RNA|THBS3_ENST00000541576.1_Missense_Mutation_p.N90S|THBS3_ENST00000541990.1_Missense_Mutation_p.N222S	NM_001252607.1|NM_007112.4	NP_001239536.1|NP_009043.1	P49746	TSP3_HUMAN	thrombospondin 3	693					cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(6)|endometrium(4)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(3)	48	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			ACCAACGCCATTGCCTGGGCA	0.537000													37	72					0	0	1	0	0
GBE1	2632	broad.mit.edu	37	3	81699052	81699052	+	Silent	SNP	G	G	A			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr3:81699052G>A	ENST00000429644.2	-	4	1093	c.450C>T	c.(448-450)agC>agT	p.S150S	GBE1_ENST00000489715.1_Silent_p.S109S	NM_000158.3	NP_000149.3	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	150					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		AGATCTCTCCGCTTTTACTAG	0.368000									Glycogen Storage Disease, type IV				3	39					0	0	1	0	0
REXO1	57455	broad.mit.edu	37	19	1828209	1828209	+	Silent	SNP	T	T	C			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr19:1828209T>C	ENST00000170168.4	-	2	673	c.579A>G	c.(577-579)ggA>ggG	p.G193G	REXO1_ENST00000587524.1_5'UTR	NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	193	Poly-Gly.					nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCACCCCCTCCACCTCTGC	0.706000													2	21					0	0	1	0	0
KRTAP8-1	0	broad.mit.edu	37	21	32185391	32185391	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr21:32185391C>T	ENST00000329621.4	-	1	179	c.148G>A	c.(148-150)Ggg>Agg	p.G50R		NM_175857.3	NP_787053.1	Q8IUC2	KRA81_HUMAN	keratin associated protein 8-1	50	12 X 2 AA repeats of G-[YCGS].					intermediate filament				central_nervous_system(1)|large_intestine(1)|lung(4)	6						CCGAAAGCCCCACAGCCGTTG	0.567000													8	160					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31600669	31600669	+	Missense_Mutation	SNP	A	A	G			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr12:31600669A>G	ENST00000389082.5	-	6	1928	c.1664T>C	c.(1663-1665)cTg>cCg	p.L555P	DENND5B_ENST00000536562.1_Missense_Mutation_p.L590P|DENND5B_ENST00000306833.6_Missense_Mutation_p.L590P|DENND5B_ENST00000354285.4_Missense_Mutation_p.L577P	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	555	dDENN.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						AAGAAATGGCAGGTAAGGCTC	0.403000													2	13					0	0	1	0	0
TMX3	54495	broad.mit.edu	37	18	66367682	66367682	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr18:66367682T>C	ENST00000299608.2	-	6	668	c.352A>G	c.(352-354)Aca>Gca	p.T118A	TMX3_ENST00000562706.1_Missense_Mutation_p.T118A|TMX3_ENST00000443099.2_Intron	NM_019022.3	NP_061895.3	Q96JJ7	TMX3_HUMAN	thioredoxin-related transmembrane protein 3	118	Thioredoxin.				cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	17						TCATCTTTTGTTCGTGGTCCT	0.254000													10	105					0	0	1	0	0
NFE2L3	9603	broad.mit.edu	37	7	26224962	26224962	+	Silent	SNP	T	T	C			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr7:26224962T>C	ENST00000056233.3	+	4	1903	c.1644T>C	c.(1642-1644)ccT>ccC	p.P548P		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	548					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						TGCATATCCCTTTTTCTGTAG	0.418000													4	79					0	0	1	0	0
STAG2	10735	broad.mit.edu	37	X	123211862	123211862	+	Missense_Mutation	SNP	T	T	G			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chrX:123211862T>G	ENST00000371160.1	+	27	3019	c.2729T>G	c.(2728-2730)aTa>aGa	p.I910R	STAG2_ENST00000218089.9_Missense_Mutation_p.I910R|STAG2_ENST00000371157.3_Missense_Mutation_p.I910R|STAG2_ENST00000371145.3_Missense_Mutation_p.I910R|STAG2_ENST00000354548.5_Missense_Mutation_p.I841R|STAG2_ENST00000371144.3_Missense_Mutation_p.I910R|STAG2_ENST00000469481.1_Intron			Q8N3U4	STAG2_HUMAN	stromal antigen 2	910					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						ACAAGGCAGATAGACAAAATT	0.313000													38	96					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45127107	45127107	+	RNA	SNP	C	C	G	rs147409399	by1000genomes	TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr17:45127107C>G	ENST00000575173.1	-	0	418																											CCTTCGTTCACCCAAGAGCAT	0.592000													3	87					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr1:115256529T>C	ENST00000369535.4	-	3	435	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(817)|p.Q61L(175)|p.Q61P(23)|p.Q61K(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			69	90					0	0	1	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38187086	38187086	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr8:38187086G>A	ENST00000317025.8	-	6	1908	c.1391C>T	c.(1390-1392)cCg>cTg	p.P464L	WHSC1L1_ENST00000527502.1_Missense_Mutation_p.P464L|WHSC1L1_ENST00000433384.2_Missense_Mutation_p.P464L|WHSC1L1_ENST00000316985.3_Missense_Mutation_p.P464L	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	464					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TTTAACAGGCGGTGGCTCTTC	0.517000			T	NUP98	AML								34	45					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14513734	14513734	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr18:14513734C>T	ENST00000358970.5	-	10	1459	c.1460G>A	c.(1459-1461)gGa>gAa	p.G487E		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	487								p.G487E(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TTGTGATATTCCAGTGTTCTG	0.323000													4	70					0	0	1	0	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													6	65					0	0	1	0	0
IDNK	414328	broad.mit.edu	37	9	86258573	86258573	+	Silent	SNP	T	T	C	rs138577393		TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr9:86258573T>C	ENST00000277124.8	+	6	1149	c.304T>C	c.(304-306)Ttg>Ctg	p.L102L	IDNK_ENST00000405990.3_3'UTR|IDNK_ENST00000376417.4_3'UTR|IDNK_ENST00000454393.1_Silent_p.L191L|IDNK_ENST00000376419.4_Silent_p.L148L	NM_001256915.1	NP_001243844.1	Q5T6J7	GNTK_HUMAN	idnK, gluconokinase homolog (E. coli)	148					carbohydrate metabolic process	cytoplasm	ATP binding|gluconokinase activity|shikimate kinase activity										CCCTGAATTATTGCAGTCCCA	0.463000													4	104					0	0	1	0	0
ZNF259	8882	broad.mit.edu	37	11	116656238	116656238	+	Missense_Mutation	SNP	C	C	A			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr11:116656238C>A	ENST00000227322.3	-	6	756	c.697G>T	c.(697-699)Ggg>Tgg	p.G233W		NM_003904.3	NP_003895.1	O75312	ZPR1_HUMAN	zinc finger protein 259	233					cell proliferation|signal transduction	cytoplasm|nucleolus				breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	9	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.61e-06)|all cancers(92;0.000139)|OV - Ovarian serous cystadenocarcinoma(223;0.153)		ACTTGAAGCCCCAGCATCTCT	0.502000													4	122					0.014758	0.0161308	1	1	0
OR6V1	346517	broad.mit.edu	37	7	142750057	142750057	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr7:142750057G>C	ENST00000418316.1	+	1	641	c.620G>C	c.(619-621)aGc>aCc	p.S207T		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					TTTGTCCTCAGCTCCTTCCTG	0.542000													4	203					0	0	1	0	0
FLVCR2	55640	broad.mit.edu	37	14	76101253	76101253	+	Splice_Site	SNP	G	G	C			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr14:76101253G>C	ENST00000238667.4	+	5	1377	c.1020_splice	c.e5-1	p.G341_splice	FLVCR2_ENST00000539311.1_Splice_Site_p.G136_splice|FLVCR2_ENST00000556241.1_3'UTR|FLVCR2_ENST00000556856.1_Intron|FLVCR2_ENST00000553587.1_Splice_Site_p.G89_splice|FLVCR2_ENST00000555027.1_Splice_Site_p.G56_splice	NM_017791.2	NP_060261.2	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular receptor family, member 2	341					transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15				BRCA - Breast invasive adenocarcinoma(234;0.029)		GTTTCCCCAGGGGGAAGAAGT	0.527000													3	25					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625941	29625941	+	Missense_Mutation	SNP	A	A	T			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr20:29625941A>T	ENST00000278882.3	+	5	565	c.185A>T	c.(184-186)gAt>gTt	p.D62V	FRG1B_ENST00000439954.2_Missense_Mutation_p.D67V|FRG1B_ENST00000358464.4_Missense_Mutation_p.D62V														p.D62V(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGCATTCAGATGCAATTGGA	0.333000													5	82					0	0	1	0	0
ZFX	7543	broad.mit.edu	37	X	24228800	24228800	+	Silent	SNP	G	G	A			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chrX:24228800G>A	ENST00000379177.1	+	11	2152	c.1725G>A	c.(1723-1725)ccG>ccA	p.P575P	ZFX_ENST00000338565.3_Silent_p.P525P|ZFX_ENST00000539115.1_Silent_p.P346P|ZFX_ENST00000379188.3_Silent_p.P575P|ZFX_ENST00000540034.1_Silent_p.P614P|ZFX_ENST00000304543.5_Silent_p.P575P	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	575					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						GGGAGAAGCCGTACCAATGCC	0.438000													3	101					0	0	1	0	0
UNC80	285175	broad.mit.edu	37	2	210658442	210658442	+	Splice_Site	SNP	A	A	G			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr2:210658442A>G	ENST00000439458.1	+	7	878		c.e7-1		UNC80_ENST00000478701.1_Splice_Site|UNC80_ENST00000272845.5_Splice_Site	NM_032504.1	NP_115893.1	Q8N2C7	UNC80_HUMAN	unc-80 homolog (C. elegans)							integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)	20						TGCCTCCAAAAGGGACTCCAG	0.428000													3	63					0	0	1	0	0
TSR1	55720	broad.mit.edu	37	17	2238870	2238870	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr17:2238870G>C	ENST00000301364.4	-	3	1435	c.356C>G	c.(355-357)aCc>aGc	p.T119S		NM_018128.4	NP_060598.3	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)	119					ribosome assembly	nucleolus	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	20						AAAGTTCTGGGTGTTTCCCAA	0.483000													3	115					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65365210	65365210	+	Silent	SNP	C	C	T			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr3:65365210C>T	ENST00000330909.8	-	18	2804	c.2805G>A	c.(2803-2805)gaG>gaA	p.E935E	MAGI1_ENST00000402939.2_Silent_p.E907E|MAGI1_ENST00000483466.1_Silent_p.E935E|MAGI1_ENST00000497477.2_Silent_p.E907E	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	935					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GCGAGGGCACCTCGTTCTCGG	0.622000													79	141					0	0	1	0	0
NANOS2	339345	broad.mit.edu	37	19	46417736	46417736	+	Silent	SNP	G	G	A			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr19:46417736G>A	ENST00000341294.2	-	1	300	c.216C>T	c.(214-216)tcC>tcT	p.S72S		NM_001029861.2	NP_001025032.1	P60321	NANO2_HUMAN	nanos homolog 2 (Drosophila)	72					germ-line stem cell maintenance|mRNA catabolic process|multicellular organismal development|negative regulation of meiosis|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|perinuclear region of cytoplasm	RNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)	6		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0668)|Epithelial(262;0.231)		AGACGTGGCGGGACTCCCCGT	0.692000													3	82					0	0	1	0	0
MGLL	11343	broad.mit.edu	37	3	127454586	127454586	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr3:127454586G>A	ENST00000398101.3	-	1	614	c.116C>T	c.(115-117)gCg>gTg	p.A39V	MGLL_ENST00000265052.5_Intron|MGLL_ENST00000453507.2_Intron|MGLL_ENST00000434178.2_Intron|MGLL_ENST00000398104.1_Intron			Q99685	MGLL_HUMAN	monoglyceride lipase	0					arachidonic acid metabolic process|fatty acid biosynthetic process|inflammatory response|platelet activation|regulation of endocannabinoid signaling pathway|regulation of inflammatory response|regulation of sensory perception of pain|triglyceride catabolic process	plasma membrane	acylglycerol lipase activity|carboxylesterase activity|lysophospholipase activity|protein homodimerization activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6						CTCGCTCCCCGCCTTCTCCCA	0.488000													4	172					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26219630	26219630	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr22:26219630G>A	ENST00000335473.7	+	13	2930	c.2680G>A	c.(2680-2682)Gag>Aag	p.E894K	MYO18B_ENST00000407587.2_Missense_Mutation_p.E894K|MYO18B_ENST00000536101.1_Missense_Mutation_p.E894K	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	894	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CCTCGAGGATGAGGAAACCAG	0.562000													4	135					0	0	1	0	0
CEP170B	283638	broad.mit.edu	37	14	105353277	105353277	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr14:105353277G>A	ENST00000453495.1	+	12	2932	c.2704G>A	c.(2704-2706)Gca>Aca	p.A902T	CEP170B_ENST00000556508.1_Missense_Mutation_p.A831T|CEP170B_ENST00000418279.1_Missense_Mutation_p.A831T|CEP170B_ENST00000414716.3_Missense_Mutation_p.A901T					centrosomal protein 170B																		TACCCGGGCCGCACGCATGGA	0.662000													3	65					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23858160	23858160	+	Silent	SNP	G	G	A			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr14:23858160G>A	ENST00000405093.3	-	29	4153	c.4083C>T	c.(4081-4083)cgC>cgT	p.R1361R	MYH6_ENST00000356287.3_Silent_p.R1361R	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1361					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle	p.R1361R(1)		breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TGGACAGGACGCGCTGCAGCT	0.647000													4	88					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	10064433	10064433	+	Silent	SNP	G	G	A			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr11:10064433G>A	ENST00000256190.8	-	3	374	c.237C>T	c.(235-237)taC>taT	p.Y79Y	SBF2_ENST00000527019.1_5'UTR	NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	79	UDENN.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		GGCATGAGCAGTAATGTCGAT	0.443000													3	138					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64457918	64457918	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr11:64457918G>C	ENST00000265459.6	-	5	1270	c.809C>G	c.(808-810)gCc>gGc	p.A270G	NRXN2_ENST00000409571.1_Missense_Mutation_p.A270G|NRXN2_ENST00000377551.1_Missense_Mutation_p.A270G|NRXN2_ENST00000377559.3_Intron	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	270					cell adhesion	integral to membrane	metal ion binding	p.A270fs*27(1)		breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						TCCTCTCCCGGCCCCCCCCTC	0.632000													3	26					0	0	1	0	0
RP11-389E17.1	0	broad.mit.edu	37	4	178897099	178897099	+	Splice_Site	SNP	T	T	C			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr4:178897099T>C	ENST00000507870.1	+	5	762		c.e5+2																		lung(8)|prostate(1)	9						AAATGCCAGGTGAGTATGCAA	0.368000													8	152					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37001181	37001181	+	Splice_Site	SNP	G	G	A			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr5:37001181G>A	ENST00000282516.8	+	14	4163		c.e14+1		NIPBL_ENST00000448238.2_Splice_Site	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)						brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			ACTGCGTTTGGTAAAATCAAC	0.333000													33	45					0	0	1	0	0
HSPA2	3306	broad.mit.edu	37	14	65008100	65008100	+	Missense_Mutation	SNP	C	C	A			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr14:65008100C>A	ENST00000247207.6	+	1	915	c.533C>A	c.(532-534)aCg>aAg	p.T178K	HSPA2_ENST00000394709.1_Missense_Mutation_p.T178K|HSPA2_ENST00000554883.1_3'UTR	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	178					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		AACGAGCCCACGGCGGCGGCC	0.642000													3	84					0.115264	0.123123	1	1	0
KDM2B	84678	broad.mit.edu	37	12	121877692	121877692	+	Missense_Mutation	SNP	G	G	T			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr12:121877692G>T	ENST00000377069.4	-	21	3996	c.3590C>A	c.(3589-3591)aCc>aAc	p.T1197N	KDM2B_ENST00000536437.1_Intron|KDM2B_ENST00000377071.4_Missense_Mutation_p.T1266N|KDM2B_ENST00000542973.1_Missense_Mutation_p.T634N	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	1266					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						GGAGTCTCGGGTGGTGGTGCC	0.572000													15	50					2.89027e-11	3.23435e-11	1	1	0
FCN2	2220	broad.mit.edu	37	9	137779025	137779025	+	Missense_Mutation	SNP	A	A	G			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr9:137779025A>G	ENST00000350339.2	+	7	606	c.592A>G	c.(592-594)Acg>Gcg	p.T198A	FCN2_ENST00000291744.6_Missense_Mutation_p.T236A	NM_015837.2	NP_056652.1	Q15485	FCN2_HUMAN	ficolin (collagen/fibrinogen domain containing lectin) 2	236	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	20		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		AGATTCCCTGACGTTCCACAA	0.468000													8	113					0	0	1	0	0
BCL10	8915	broad.mit.edu	37	1	85736511	85736511	+	Frame_Shift_Del	DEL	T	T	-			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr1:85736511delT	ENST00000370580.1	-	2	873	c.136delA	c.(136-138)tafs	p.I46fs		NM_003921.4	NP_003912.1	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	46	CARD.				apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding	p.I46fs*4(1)		haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	19				all cancers(265;0.0114)|Epithelial(280;0.0311)		CTACTGAGTATTTTTTTTGCA	0.343			T	IGH@	MALT								7	110	---	---	---	---					
TRIM33	51592	broad.mit.edu	37	1	114968116	114968118	+	In_Frame_Del	DEL	TGT	TGT	-			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr1:114968116_114968118delTGT	ENST00000358465.2	-	9	1731_1733	c.1648_1650delACA	c.(1648-1650)del	p.T550del	TRIM33_ENST00000450349.2_In_Frame_Del_p.T158del|TRIM33_ENST00000369543.2_In_Frame_Del_p.T550del	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	550	Poly-Thr.				negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GATGCTGTTGTGTTGTTGTTGTT	0.429			T	RET	papillary thyroid								7	366	---	---	---	---					
WNT6	7475	broad.mit.edu	37	2	219724790	219724792	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr2:219724790_219724792delGCT	ENST00000233948.3	+	1	247_249	c.30_32delGCT	c.(28-33)ggg>gg	p.GL10del	WNT6_ENST00000486233.1_3'UTR	NM_006522.3	NP_006513.1	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family, member 6	10					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity	p.L17delL(1)		large_intestine(1)|ovary(2)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCGCCTCGGGCTGCTGCTGCTG	0.773													2	4	---	---	---	---					
CACNA1D	776	broad.mit.edu	37	3	53529193	53529195	+	Translation_Start_Site	DEL	GAT	GAT	-			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr3:53529193_53529195delGAT	ENST00000288139.3	+	0	118_120				CACNA1D_ENST00000350061.5_Start_Codon_Del|CACNA1D_ENST00000422281.2_Start_Codon_Del	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit						axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	aatgttcgtGgatgatgatgatg	0.581													7	190	---	---	---	---					
PCSK5	5125	broad.mit.edu	37	9	78790207	78790208	+	Frame_Shift_Ins	INS	-	-	GAATA	rs55947300		TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr9:78790207_78790208insGAATA	ENST00000376767.3	+	14	2574_2575	c.2062_2063insGAATA	c.(2062-2064)aatfs	p.N688fs	PCSK5_ENST00000376752.4_Intron|PCSK5_ENST00000545128.1_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						cgaatcgaatcgaatagaatag	0.342													3	3	---	---	---	---					
IGHV3-21	0	broad.mit.edu	37	14	106691799	106691801	+	RNA	DEL	ACT	ACT	-			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr14:106691799_106691801delACT	ENST00000390607.2	-	0	301_303																											AGTATATGTAACTACTACTACTA	0.517													7	338	---	---	---	---					
ADAMTS18	170692	broad.mit.edu	37	16	77356311	77356311	+	Frame_Shift_Del	DEL	A	A	-			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr16:77356311delA	ENST00000282849.5	-	14	2503	c.2085delT	c.(2083-2085)ttfs	p.F695fs		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	695	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.A696fs*18(2)		NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						CGGACATTGCAAAAAAAAATT	0.403													7	130	---	---	---	---					
ABCA6	23460	broad.mit.edu	37	17	67125767	67125767	+	Frame_Shift_Del	DEL	A	A	-			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr17:67125767delA	ENST00000284425.2	-	7	1091	c.917delT	c.(916-918)tafs	p.L306fs		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	306					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					TAAGCCATATAAAAAAAAGAG	0.308													7	105	---	---	---	---					
CTC-513N18.6	0	broad.mit.edu	37	19	20663034	20663034	+	RNA	DEL	G	G	-			TCGA-EL-A3T2-01A-11D-A22D-08	TCGA-EL-A3T2-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2155c3ec-aa6e-41bf-9092-94b89ba47845	38f0d4b5-0437-48dd-81cf-8e1d9d0ec2ea	g.chr19:20663034delG	ENST00000598131.1	+	0	256																											agcttcttttgtccagctgct	0.537													3	6	---	---	---	---