Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LPHN1	22859	broad.mit.edu	37	19	14261877	14261877	+	Silent	SNP	T	T	G			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr19:14261877T>G	ENST00000340736.6	-	24	4530	c.4233A>C	c.(4231-4233)ccA>ccC	p.P1411P	CTB-55O6.12_ENST00000588387.1_RNA|LPHN1_ENST00000361434.3_Silent_p.P1406P|CTB-55O6.12_ENST00000588658.1_RNA	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	1411	Poly-Pro.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CGGGAGGGGGTGGGGGCAGGG	0.731000													4	6					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468821	56468821	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr3:56468821G>A	ENST00000288221.6	-	2	470	c.215C>T	c.(214-216)tCa>tTa	p.S72L		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	72						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GTAGGTTGTTGAAGCCACCCC	0.507000													4	215					0	0	1	0	0
EDA	1896	broad.mit.edu	37	X	69253267	69253267	+	Silent	SNP	C	C	T			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chrX:69253267C>T	ENST00000374552.4	+	7	1055	c.813C>T	c.(811-813)ctC>ctT	p.L271L	EDA_ENST00000524573.1_Silent_p.L268L|EDA_ENST00000374553.2_Silent_p.L271L	NM_001399.4	NP_001390.1	Q92838	EDA_HUMAN	ectodysplasin A	271					cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|urinary_tract(1)	14						GTGGAGTGCTCAATGACTGGT	0.478000											OREG0019847	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	273					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38352357	38352357	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr5:38352357G>A	ENST00000322350.5	+	5	815	c.469G>A	c.(469-471)Gag>Aag	p.E157K	EGFLAM_ENST00000354891.3_Missense_Mutation_p.E157K	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	157	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TTCGGATTCTGAGGTGGCCCT	0.507000													18	188					0	0	1	0	0
RASGRP1	10125	broad.mit.edu	37	15	38810529	38810529	+	Missense_Mutation	SNP	T	T	G			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr15:38810529T>G	ENST00000310803.5	-	5	662	c.485A>C	c.(484-486)gAg>gCg	p.E162A	RASGRP1_ENST00000559830.1_Missense_Mutation_p.E162A|RASGRP1_ENST00000450598.2_Missense_Mutation_p.E162A|RASGRP1_ENST00000539159.1_Missense_Mutation_p.E114A|RASGRP1_ENST00000561180.1_Missense_Mutation_p.E213A|RASGRP1_ENST00000558164.1_Missense_Mutation_p.E162A	NM_001128602.1|NM_005739.3	NP_001122074.1|NP_005730.2	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	162	N-terminal Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		ATGTAACTCCTCACCCTTAGC	0.443000													17	13					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36334403	36334403	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr19:36334403G>A	ENST00000378910.5	-	17	2304	c.2305C>T	c.(2305-2307)Ctc>Ttc	p.L769F	NPHS1_ENST00000353632.6_Missense_Mutation_p.L769F	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	769	Ig-like C2-type 7.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATGCCCGGGAGGATGGGATTG	0.572000													5	357					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37882044	37882044	+	Missense_Mutation	SNP	A	A	G			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr17:37882044A>G	ENST00000406381.2	+	25	3230	c.2720A>G	c.(2719-2721)aAg>aGg	p.K907R	ERBB2_ENST00000269571.5_Missense_Mutation_p.K937R|ERBB2_ENST00000584601.1_Missense_Mutation_p.K907R|ERBB2_ENST00000584450.1_Missense_Mutation_p.K937R|ERBB2_ENST00000445658.2_Missense_Mutation_p.K661R|ERBB2_ENST00000541774.1_Missense_Mutation_p.K922R|ERBB2_ENST00000540147.1_Missense_Mutation_p.K907R	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	937	Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CTGCTGGAAAAGGGGGAGCGG	0.592000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			4	117					0	0	1	0	0
C15orf27	123591	broad.mit.edu	37	15	76467946	76467946	+	Silent	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr15:76467946G>A	ENST00000388942.3	+	8	975	c.699G>A	c.(697-699)caG>caA	p.Q233Q	RP11-593F23.1_ENST00000558424.1_RNA	NM_152335.2	NP_689548.2	Q2M3C6	CO027_HUMAN	chromosome 15 open reading frame 27	233						integral to membrane				endometrium(1)|large_intestine(1)|lung(10)|pancreas(1)	13						TTATCCAGCAGTACGAGAAGG	0.552000													3	102					0	0	1	0	0
ABI2	10152	broad.mit.edu	37	2	204259430	204259430	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr2:204259430T>C	ENST00000295851.4	+	6	882	c.586T>C	c.(586-588)Tcc>Ccc	p.S196P	ABI2_ENST00000422511.2_Missense_Mutation_p.S196P|RAPH1_ENST00000457812.1_3'UTR|ABI2_ENST00000430574.1_3'UTR|ABI2_ENST00000261016.6_Missense_Mutation_p.S145P|ABI2_ENST00000261017.5_Missense_Mutation_p.S190P|ABI2_ENST00000261018.7_Intron|ABI2_ENST00000430418.1_Intron|ABI2_ENST00000424558.1_Missense_Mutation_p.S190P			Q9NYB9	ABI2_HUMAN	abl-interactor 2	196	Pro-rich.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding			breast(1)|kidney(3)|large_intestine(1)|liver(2)|lung(4)|prostate(2)|skin(1)|urinary_tract(1)	15						TAGGCGGCACTCCCCCTATCG	0.473000													3	190					0	0	1	0	0
DDX18	8886	broad.mit.edu	37	2	118583110	118583110	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr2:118583110G>A	ENST00000263239.2	+	10	1584	c.1456G>A	c.(1456-1458)Gcg>Acg	p.A486T		NM_006773.3	NP_006764.3	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	486	Helicase C-terminal.						ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GGATGTGGCAGCGAGAGGACT	0.433000													3	131					0	0	1	0	0
LATS2	26524	broad.mit.edu	37	13	21562776	21562776	+	Silent	SNP	C	C	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr13:21562776C>A	ENST00000382592.4	-	4	1548	c.1143G>T	c.(1141-1143)ctG>ctT	p.L381L	LATS2_ENST00000542899.1_Silent_p.L381L	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	381					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CCGGCTTCTGCAGGGAGTCCC	0.701000													3	39					1	1	1	1	0
C10orf90	118611	broad.mit.edu	37	10	128193188	128193188	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr10:128193188G>A	ENST00000284694.7	-	3	701	c.581C>T	c.(580-582)gCc>gTc	p.A194V	C10orf90_ENST00000356858.3_Missense_Mutation_p.A147V|C10orf90_ENST00000392694.1_Missense_Mutation_p.A147V|C10orf90_ENST00000544758.1_Missense_Mutation_p.A291V|C10orf90_ENST00000368674.1_5'UTR|C10orf90_ENST00000454341.1_Missense_Mutation_p.A194V	NM_001004298.2	NP_001004298.2	Q96M02	CJ090_HUMAN	chromosome 10 open reading frame 90	194										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(19)|liver(1)|lung(29)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	65		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		CTCTGTGCAGGCAAAAGATCT	0.612000											OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	153					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168352394	168352394	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr6:168352394C>G	ENST00000366806.2	+	30	4481	c.4339C>G	c.(4339-4341)Cag>Gag	p.Q1447E	MLLT4_ENST00000392108.3_Missense_Mutation_p.Q1447E|MLLT4_ENST00000392112.1_Missense_Mutation_p.Q1430E|MLLT4_ENST00000400822.3_Missense_Mutation_p.Q1446E|MLLT4_ENST00000344191.4_Missense_Mutation_p.Q1447E|MLLT4_ENST00000351017.4_Missense_Mutation_p.Q1454E|MLLT4_ENST00000447894.2_Missense_Mutation_p.Q1447E			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	1447					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GATGCGCACTCAGTCCTTAAA	0.577000			T	MLL	AL								17	263					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61542301	61542301	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr20:61542301C>T	ENST00000266070.4	-	3	989	c.664G>A	c.(664-666)Gat>Aat	p.D222N	DIDO1_ENST00000266071.5_Missense_Mutation_p.D222N|DIDO1_ENST00000395343.1_Missense_Mutation_p.D222N|DIDO1_ENST00000395335.2_Missense_Mutation_p.D222N|DIDO1_ENST00000370366.1_Missense_Mutation_p.D222N|DIDO1_ENST00000370368.1_Missense_Mutation_p.D222N|DIDO1_ENST00000370371.4_Missense_Mutation_p.D222N|DIDO1_ENST00000354665.4_Missense_Mutation_p.D222N|DIDO1_ENST00000395340.1_Missense_Mutation_p.D222N	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	222					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					ACCCCCTGATCGTTCTCGGGC	0.622000													4	72					0	0	1	0	0
RBBP4	5928	broad.mit.edu	37	1	33123032	33123032	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr1:33123032G>A	ENST00000373493.5	+	3	328	c.169G>A	c.(169-171)Gaa>Aaa	p.E57K	RBBP4_ENST00000373485.1_Missense_Mutation_p.E57K|RBBP4_ENST00000414241.3_Missense_Mutation_p.E56K|RBBP4_ENST00000544435.1_Intron|RBBP4_ENST00000524393.1_Intron|RBBP4_ENST00000458695.2_Missense_Mutation_p.E22K	NM_001135255.1|NM_005610.2	NP_001128727.1|NP_005601.1	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4	57					cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|ovary(1)|prostate(4)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				TTACAGACCAGAAGGGAAAGA	0.413000													6	107					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027156	37027156	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chrX:37027156C>G	ENST00000358047.3	+	1	725	c.673C>G	c.(673-675)Cag>Gag	p.Q225E		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	225										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TCTCCGCCCACAGCCTCCCAA	0.647000													5	135					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12957624	12957624	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr8:12957624C>G	ENST00000276297.4	-	9	2631	c.2222G>C	c.(2221-2223)aGc>aCc	p.S741T	DLC1_ENST00000520226.1_Missense_Mutation_p.S230T|DLC1_ENST00000358919.2_Missense_Mutation_p.S304T|DLC1_ENST00000512044.2_Missense_Mutation_p.S338T	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	741	Poly-Ser.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GCTGCTGCTGCTGGTCTGCGT	0.627000													3	98					0	0	1	0	0
DYRK1B	9149	broad.mit.edu	37	19	40318234	40318234	+	Silent	SNP	G	G	A	rs78838108	byFrequency	TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr19:40318234G>A	ENST00000593685.1	-	7	1338	c.870C>T	c.(868-870)taC>taT	p.Y290Y	DYRK1B_ENST00000430012.2_Silent_p.Y290Y|DYRK1B_ENST00000323039.5_Silent_p.Y290Y|DYRK1B_ENST00000597639.1_Silent_p.Y290Y|DYRK1B_ENST00000348817.3_Silent_p.Y290Y			Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	290	Protein kinase.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(7)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	24	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			TGGCCAGGTCGTAGGGTGTGC	0.597000													3	116					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625947	29625947	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr20:29625947T>C	ENST00000278882.3	+	5	571	c.191T>C	c.(190-192)aTt>aCt	p.I64T	FRG1B_ENST00000358464.4_Missense_Mutation_p.I64T|FRG1B_ENST00000439954.2_Missense_Mutation_p.I69T														p.I64T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCAGATGCAATTGGACCAAGA	0.343000													5	63					0	0	1	0	0
ZBTB3	79842	broad.mit.edu	37	11	62520401	62520401	+	Silent	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr11:62520401G>A	ENST00000394807.3	-	2	1011	c.886C>T	c.(886-888)Ctg>Ttg	p.L296L		NM_024784.3	NP_079060.1	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	296	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|ovary(2)|prostate(2)	24						AGAGATGGCAGTGGCTCCAAT	0.542000													3	88					0	0	1	0	0
IRF4	3662	broad.mit.edu	37	6	407546	407546	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr6:407546G>A	ENST00000380956.4	+	9	1430	c.1304G>A	c.(1303-1305)aGc>aAc	p.S435N		NM_001195286.1|NM_002460.3	NP_001182215.1|NP_002451.2	Q15306	IRF4_HUMAN	interferon regulatory factor 4	435					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		GAACACATCAGCAATCCAGAA	0.353000			T	IGH@	MM								3	67					0	0	1	0	0
SYTL4	94121	broad.mit.edu	37	X	99942164	99942164	+	Missense_Mutation	SNP	A	A	G			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chrX:99942164A>G	ENST00000455616.1	-	12	1430	c.1084T>C	c.(1084-1086)Ttt>Ctt	p.F362L	SYTL4_ENST00000276141.6_Missense_Mutation_p.F362L|SYTL4_ENST00000372989.1_Missense_Mutation_p.F362L|SYTL4_ENST00000454200.2_Missense_Mutation_p.F364L|SYTL4_ENST00000372981.1_3'UTR|SYTL4_ENST00000263033.5_Missense_Mutation_p.F362L			Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	362	C2 1.				exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(2)	27					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTCAGGGAAAAGGCAATCCTG	0.502000													3	114					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55659057	55659057	+	Silent	SNP	T	T	C			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr11:55659057T>C	ENST00000449290.2	+	7	1400	c.1308T>C	c.(1306-1308)aaT>aaC	p.N436N	TRIM51_ENST00000244891.3_Silent_p.N293N	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	436	B30.2/SPRY.					intracellular	zinc ion binding										CCATCCCCAATTGCTCCTTCT	0.453000													12	198					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113920471	113920471	+	Silent	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr10:113920471G>A	ENST00000348367.4	-	16	1847	c.1650C>T	c.(1648-1650)agC>agT	p.S550S	GPAM_ENST00000423155.1_Silent_p.S550S|GPAM_ENST00000369425.1_Silent_p.S550S			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	550					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		CATCGTTCCTGCTAGTGTGGG	0.458000													38	51					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65871028	65871028	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr17:65871028G>C	ENST00000321892.4	+	4	1817	c.1756G>C	c.(1756-1758)Gac>Cac	p.D586H	BPTF_ENST00000335221.5_Missense_Mutation_p.D586H|BPTF_ENST00000306378.6_Missense_Mutation_p.D586H|BPTF_ENST00000424123.3_Missense_Mutation_p.D447H			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	586					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			GACTGAGAATGACTCTAAAGA	0.373000													4	48					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44815233	44815233	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr20:44815233T>C	ENST00000372262.3	-	9	2057	c.1657A>G	c.(1657-1659)Atc>Gtc	p.I553V	CDH22_ENST00000537909.1_Missense_Mutation_p.I553V	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	553	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				TCACCTTGGATGTCAAGCAGA	0.592000													5	132					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19677526	19677526	+	Missense_Mutation	SNP	G	G	T			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr20:19677526G>T	ENST00000328041.6	+	14	1774	c.1577G>T	c.(1576-1578)tGc>tTc	p.C526F		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	526						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GTGCCTGACTGCATGGCCAGC	0.597000													5	126					5.9392e-07	6.05342e-07	1	1	0
SCN5A	6331	broad.mit.edu	37	3	38591931	38591931	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr3:38591931C>G	ENST00000413689.1	-	28	6125	c.5932G>C	c.(5932-5934)Gac>Cac	p.D1978H	SCN5A_ENST00000455624.2_Missense_Mutation_p.D1945H|SCN5A_ENST00000451551.2_Missense_Mutation_p.D1924H|SCN5A_ENST00000450102.2_Missense_Mutation_p.D1924H|SCN5A_ENST00000449557.2_Missense_Mutation_p.D1924H|SCN5A_ENST00000443581.1_Missense_Mutation_p.D1977H|SCN5A_ENST00000425664.1_Missense_Mutation_p.D1960H|SCN5A_ENST00000423572.2_Missense_Mutation_p.D1977H|SCN5A_ENST00000414099.2_Missense_Mutation_p.D1960H|SCN5A_ENST00000333535.4_Missense_Mutation_p.D1978H	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1978					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTGACACTGTCATAGGAGGGT	0.602000													3	74					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169494626	169494626	+	Missense_Mutation	SNP	T	T	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr5:169494626T>A	ENST00000256935.8	+	45	4660	c.4580T>A	c.(4579-4581)cTc>cAc	p.L1527H	DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000540750.1_Missense_Mutation_p.L588H|DOCK2_ENST00000520908.1_Missense_Mutation_p.L1019H	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1527	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding	p.L1527H(1)		NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCAACCCACTCTCCATGCTC	0.522000													4	127					0	0	1	0	0
MT-CO2	4513	broad.mit.edu	37	MT	8020	8020	+	Silent	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chrM:8020G>A	ENST00000361739.1	+	1	435	c.435G>A	c.(433-435)ccG>ccA	p.P145P						mitochondrially encoded cytochrome c oxidase II											endometrium(5)|kidney(8)|lung(2)|pancreas(3)|prostate(1)	19						GTAGTACTCCCGATTGAAGCC	0.473000													5	0					0	0	1	0	0
TBC1D2	55357	broad.mit.edu	37	9	101017574	101017574	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr9:101017574C>G	ENST00000375066.5	-	1	341	c.250G>C	c.(250-252)Gct>Cct	p.A84P	TBC1D2_ENST00000375064.1_Missense_Mutation_p.A84P|TBC1D2_ENST00000342112.5_5'UTR	NM_018421.3	NP_060891.3	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	84	Interaction with CADH1.|PH.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		GCATCCTGAGCGGTCCGCGAG	0.542000													7	97					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7640590	7640590	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr12:7640590G>A	ENST00000359156.4	-	7	1716	c.1514C>T	c.(1513-1515)tCg>tTg	p.S505L	CD163_ENST00000432237.2_Missense_Mutation_p.S505L|CD163_ENST00000396620.3_Missense_Mutation_p.S505L|CD163_ENST00000541972.1_Missense_Mutation_p.S493L	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	505	SRCR 5.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity	p.S505*(1)		breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						AGAGAAGTCCGAATCACAGAT	0.537000													3	80					0	0	1	0	0
FLNA	0	broad.mit.edu	37	X	153599581	153599581	+	Silent	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chrX:153599581G>A	ENST00000422373.1	-	2	281	c.33C>T	c.(31-33)agC>agT	p.S11S	FLNA_ENST00000369850.3_Silent_p.S11S|FLNA_ENST00000344736.4_Silent_p.S11S|FLNA_ENST00000360319.4_Silent_p.S11S	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	11	Actin-binding.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CGCCTGCTGCGCTCTGGCCCG	0.701000													4	2					0	0	1	0	0
ITGAL	0	broad.mit.edu	37	16	30507512	30507512	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr16:30507512G>A	ENST00000356798.6	+	14	1778	c.1598G>A	c.(1597-1599)gGc>gAc	p.G533D	ITGAL_ENST00000358164.5_Missense_Mutation_p.G450D|ITGAL_ENST00000568012.1_3'UTR|ITGAL_ENST00000433423.2_Intron	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	533					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GACATCAACGGCGATGGGCTG	0.617000													6	243					0	0	1	0	0
LIPT1	51601	broad.mit.edu	37	2	99778836	99778836	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr2:99778836C>G	ENST00000393477.3	+	4	768	c.416C>G	c.(415-417)gCt>gGt	p.A139G	MRPL30_ENST00000410042.1_Intron|LIPT1_ENST00000393471.2_Missense_Mutation_p.A139G|LIPT1_ENST00000393473.2_Missense_Mutation_p.A139G|LIPT1_ENST00000393474.3_Missense_Mutation_p.A139G|LIPT1_ENST00000340066.1_Missense_Mutation_p.A139G	NM_145197.2	NP_660198.1	Q9Y234	LIPT_HUMAN	lipoyltransferase 1	139					lipid metabolic process|protein lipoylation	mitochondrion	acyltransferase activity			large_intestine(6)|lung(1)	7					Lipoic Acid(DB00166)	GCTCTGAATGCTGTCCAACCC	0.383000													5	76					0	0	1	0	0
TMEM225	338661	broad.mit.edu	37	11	123753862	123753862	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr11:123753862C>T	ENST00000375026.2	-	4	877	c.661G>A	c.(661-663)Gta>Ata	p.V221I		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	221						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						GCCCAGGTTACGTGACGTGTT	0.423000													35	63					0	0	1	0	0
DPP7	29952	broad.mit.edu	37	9	140006389	140006389	+	Silent	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr9:140006389G>A	ENST00000371579.2	-	10	1147	c.1143C>T	c.(1141-1143)taC>taT	p.Y381Y		NM_013379.2	NP_037511.2	Q9UHL4	DPP2_HUMAN	dipeptidyl-peptidase 7	381						cytoplasmic membrane-bounded vesicle|extracellular region|lysosome	aminopeptidase activity|protein binding|serine-type peptidase activity			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;4.25e-05)|Epithelial(140;0.000633)		TGTCCAGGCAGTACCGCTGGC	0.657000													3	78					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35870639	35870639	+	Missense_Mutation	SNP	A	A	G			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr1:35870639A>G	ENST00000314607.6	+	24	3624	c.3544A>G	c.(3544-3546)Ata>Gta	p.I1182V	ZMYM4_ENST00000373297.2_Missense_Mutation_p.I1093V	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	1182					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GAAGAAGTCTATAGTGGCTGT	0.413000													7	112					0	0	1	0	0
UBASH3B	84959	broad.mit.edu	37	11	122659906	122659906	+	Silent	SNP	C	C	T			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr11:122659906C>T	ENST00000284273.5	+	6	1245	c.870C>T	c.(868-870)agC>agT	p.S290S		NM_032873.4	NP_116262.2	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing B	290	SH3.					cytoplasm|nucleus	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|prostate(1)|skin(2)|stomach(2)	26		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		AGCAGACCAGCACCAGCGAGG	0.532000													6	437					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				31	45					0	0	1	0	0
GPR78	27201	broad.mit.edu	37	4	8588779	8588779	+	Splice_Site	SNP	A	A	T			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr4:8588779A>T	ENST00000382487.4	+	3	1199		c.e3-1		GPR78_ENST00000509216.1_Splice_Site	NM_080819.4	NP_543009.2	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78						activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|kidney(4)|large_intestine(1)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26						CTTCCCCAACAGGCTGGCGGA	0.627000													34	63					0	0	1	0	0
TMEM255B	348013	broad.mit.edu	37	13	114469169	114469169	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr13:114469169G>A	ENST00000375353.3	+	2	155	c.128G>A	c.(127-129)gGg>gAg	p.G43E		NM_182614.2	NP_872420.1			transmembrane protein 255B																		GTCACCGTCGGGCTGGCTGCC	0.652000													68	85					0	0	1	0	0
WDR7	23335	broad.mit.edu	37	18	54362346	54362346	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr18:54362346G>A	ENST00000254442.3	+	11	1485	c.1274G>A	c.(1273-1275)cGt>cAt	p.R425H	WDR7_ENST00000357574.3_Missense_Mutation_p.R425H|WDR7_ENST00000589935.1_Intron	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	425										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		GTTTGTGGTCGTGAAGATGGA	0.448000													3	104					0	0	1	0	0
C1QA	712	broad.mit.edu	37	1	22965567	22965567	+	Silent	SNP	G	G	C			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr1:22965567G>C	ENST00000374642.3	+	3	609	c.405G>C	c.(403-405)acG>acC	p.T135T	C1QA_ENST00000402322.1_Silent_p.T135T	NM_015991.2	NP_057075.1	P02745	C1QA_HUMAN	complement component 1, q subcomponent, A chain	135	C1q.				cell-cell signaling|complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				autonomic_ganglia(1)|liver(1)|lung(3)|skin(1)	6		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.41e-27)|Colorectal(126;1.52e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.63e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000541)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCTTCGACACGGTCATCACCA	0.602000													3	67					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195392917	195392917	+	RNA	DEL	T	T	-			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr3:195392917delT	ENST00000445430.1	+	0	647																											CTTCTTGCCCTTTTTTTTTCT	0.418													2	4	---	---	---	---					
PLEC	5339	broad.mit.edu	37	8	145000951	145000953	+	Splice_Site	DEL	CCT	CCT	-			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr8:145000951_145000953delCCT	ENST00000322810.4	-	30	4623_4625	c.4455_splice	c.e30+1	p.G1485_splice	PLEC_ENST00000356346.3_Splice_Site_p.G1334_splice|PLEC_ENST00000436759.2_Splice_Site_p.G1375_splice|PLEC_ENST00000354589.3_Splice_Site_p.G1348_splice|PLEC_ENST00000398774.2_Splice_Site_p.G1316_splice|PLEC_ENST00000527096.1_Splice_Site_p.G1371_splice|PLEC_ENST00000357649.2_Splice_Site_p.G1352_splice|PLEC_ENST00000345136.3_Splice_Site_p.G1348_splice|PLEC_ENST00000354958.2_Splice_Site_p.G1326_splice	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	1485	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						ACGGGCTGTACCTCCTCCTCCTC	0.621													8	444	---	---	---	---					
LATS2	26524	broad.mit.edu	37	13	21562482	21562483	+	In_Frame_Ins	INS	-	-	GGGGCG	rs56252009		TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr13:21562482_21562483insGGGGCG	ENST00000382592.4	-	4	1841_1842	c.1436_1437insCGCCCC	c.(1435-1437)cgc>cCGCCCCgc	p.478_479insPP	LATS2_ENST00000542899.1_In_Frame_Ins_p.478_479insPP	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	478					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.P473_A480delPAPAPAPA(2)|p.P479_A480insGR(1)		breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CCTCCGCAgccggggcgggggc	0.787													4	4	---	---	---	---					
CBX3P2	0	broad.mit.edu	37	18	2652677	2652678	+	RNA	DEL	AC	AC	-			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr18:2652677_2652678delAC	ENST00000579647.1	-	0	919_920					NR_033754.2																						CCTAGGTTTTACACACACACAC	0.342													2	4	---	---	---	---					
RYR1	6261	broad.mit.edu	37	19	38948159	38948160	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr19:38948159_38948160delTG	ENST00000355481.4	+	17	1945_1946	c.1814_1815delTG	c.(1813-1815)cfs	p.L605fs	RYR1_ENST00000360985.3_Frame_Shift_Del_p.L605fs|RYR1_ENST00000359596.3_Frame_Shift_Del_p.L605fs	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	605	B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTATGCTCCCTGTGTGTGTGTA	0.530													7	420	---	---	---	---					
ZC3H4	23211	broad.mit.edu	37	19	47572401	47572403	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-EL-A3T3-01A-11D-A22D-08	TCGA-EL-A3T3-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29bd75e4-6e49-4190-ba27-42fbb7224820	6c9c7ebe-6dc7-4ed6-b704-a37199ee44e6	g.chr19:47572401_47572403delCTC	ENST00000253048.5	-	14	2381_2383	c.2344_2346delGAG	c.(2344-2346)del	p.E782del	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	782							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		TCCTCGCTCTCTCCTCCTCCTCC	0.700													8	253	---	---	---	---