Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TULP2	7288	broad.mit.edu	37	19	49387078	49387078	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr19:49387078C>T	ENST00000221399.3	-	11	1352	c.1208G>A	c.(1207-1209)cGg>cAg	p.R403Q		NM_003323.2	NP_003314.2	O00295	TULP2_HUMAN	tubby like protein 2	403					visual perception	cytoplasm|extracellular region				NS(1)|breast(2)|central_nervous_system(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	22		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		AGTCATTTTCCGAGGCCCCAG	0.512000													27	41					0	0	1	0	0
VCL	7414	broad.mit.edu	37	10	75874123	75874123	+	Missense_Mutation	SNP	G	G	T			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr10:75874123G>T	ENST00000211998.4	+	20	3225	c.3131G>T	c.(3130-3132)cGg>cTg	p.R1044L	VCL_ENST00000372755.3_Missense_Mutation_p.R976L|VCL_ENST00000417648.2_Missense_Mutation_p.R237L	NM_014000.2	NP_054706.1	P18206	VINC_HUMAN	vinculin	1044	C-terminal tail.|Facilitates phospholipid membrane insertion (By similarity).				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Prostate(51;0.0112)					ACAGATAAACGGATTAGAACC	0.552000													16	35					6.31663e-08	6.63246e-08	1	1	0
LYPD4	147719	broad.mit.edu	37	19	42342217	42342217	+	Silent	SNP	G	G	A			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr19:42342217G>A	ENST00000330743.3	-	4	1541	c.330C>T	c.(328-330)tgC>tgT	p.C110C	LYPD4_ENST00000601246.1_Silent_p.C75C|LYPD4_ENST00000343055.4_Silent_p.C75C	NM_173506.4	NP_775777.3	Q6UWN0	LYPD4_HUMAN	LY6/PLAUR domain containing 4	110						anchored to membrane|plasma membrane				breast(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|skin(2)	12						GATAAGACCGGCAGACGCGAC	0.532000													38	90					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65350583	65350583	+	Missense_Mutation	SNP	T	T	C			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr3:65350583T>C	ENST00000330909.8	-	20	3318	c.3319A>G	c.(3319-3321)Att>Gtt	p.I1107V	MAGI1_ENST00000402939.2_Missense_Mutation_p.I1079V|MAGI1_ENST00000497477.2_Missense_Mutation_p.I1012V|MAGI1_ENST00000483466.1_Missense_Mutation_p.I1108V	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	1108					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		ATGGTGGCAATCTTCTCTGCA	0.498000													65	116					0	0	1	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72953665	72953665	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr15:72953665G>A	ENST00000421285.3	+	8	625	c.625G>A	c.(625-627)Gcg>Acg	p.A209T		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	209										NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						AAAGGAGCGGGCGCTGCTGAA	0.592000													5	55					0	0	1	0	0
CAP2	10486	broad.mit.edu	37	6	17539622	17539622	+	Missense_Mutation	SNP	A	A	T			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr6:17539622A>T	ENST00000229922.2	+	8	1291	c.759A>T	c.(757-759)aaA>aaT	p.K253N	CAP2_ENST00000489374.1_Missense_Mutation_p.K141N|CAP2_ENST00000493172.1_Intron|CAP2_ENST00000378990.2_Missense_Mutation_p.K227N|CAP2_ENST00000465994.1_Missense_Mutation_p.K189N	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	253					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			AAGGCAAAAAAGAGGAATCTT	0.517000													30	72					0	0	1	0	0
WNT7B	7477	broad.mit.edu	37	22	46345891	46345891	+	Silent	SNP	G	G	A			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr22:46345891G>A	ENST00000339464.4	-	2	581	c.207C>T	c.(205-207)ggC>ggT	p.G69G	WNT7B_ENST00000409496.3_Silent_p.G73G|WNT7B_ENST00000410058.1_Silent_p.G69G|WNT7B_ENST00000410089.1_Silent_p.G53G	NM_058238.2	NP_478679.1	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family, member 7B	69					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	19		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		ACTCGTTGATGCCCATCTGCG	0.622000													14	48					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27167581	27167581	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr2:27167581G>A	ENST00000288699.6	+	12	1656	c.1498G>A	c.(1498-1500)Gtg>Atg	p.V500M	DPYSL5_ENST00000401478.1_Missense_Mutation_p.V500M	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	500					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	p.V500M(1)		breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGCTGTTGTCGTGCACCCTGG	0.567000													42	87					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628299	29628299	+	Missense_Mutation	SNP	A	A	G			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr20:29628299A>G	ENST00000278882.3	+	6	681	c.301A>G	c.(301-303)Agt>Ggt	p.S101G	FRG1B_ENST00000439954.2_Missense_Mutation_p.S106G|FRG1B_ENST00000358464.4_Missense_Mutation_p.S101G																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AGAAGCAAAAAGTAAAACAGC	0.363000													4	119					0	0	1	0	0
METTL14	57721	broad.mit.edu	37	4	119631352	119631352	+	Silent	SNP	T	T	A			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr4:119631352T>A	ENST00000388822.4	+	11	1433	c.1266T>A	c.(1264-1266)tcT>tcA	p.S422S	METTL14_ENST00000506780.1_Silent_p.S384S			Q9HCE5	MTL14_HUMAN	methyltransferase like 14	422	Gly-rich.					nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|stomach(1)	16						GTGGAACTTCTGCTGGCCGTG	0.532000													16	40					0	0	1	0	0
AC006293.3	0	broad.mit.edu	37	19	55221570	55221570	+	RNA	SNP	A	A	C			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr19:55221570A>C	ENST00000413439.1	+	0	1350																											TACAGATGCTACGGTGCACAC	0.677000													6	67					0	0	1	0	0
OR51I1	390063	broad.mit.edu	37	11	5462660	5462660	+	Missense_Mutation	SNP	C	C	A			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr11:5462660C>A	ENST00000380211.1	-	1	84	c.85G>T	c.(85-87)Gtt>Ttt	p.V29F	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron|AC104389.28_ENST00000415970.1_RNA	NM_001005288.2	NP_001005288.1	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I, member 1	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCAGGGCAACCCAGGTGAGG	0.522000													27	87					7.41945e-09	7.99018e-09	1	1	0
ZNF74	7625	broad.mit.edu	37	22	20760482	20760482	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr22:20760482C>T	ENST00000400451.2	+	5	1673	c.1159C>T	c.(1159-1161)Ccc>Tcc	p.P387S	ZNF74_ENST00000405993.1_Missense_Mutation_p.P355S|ZNF74_ENST00000356671.5_Missense_Mutation_p.P387S|ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000403682.3_3'UTR	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	387					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GGGCGAGAAGCCCTACCAGTG	0.647000													30	65					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87925716	87925716	+	Silent	SNP	C	C	G			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr6:87925716C>G	ENST00000369577.3	+	2	307	c.264C>G	c.(262-264)gcC>gcG	p.A88A	ZNF292_ENST00000369578.2_3'UTR|ZNF292_ENST00000339907.4_Silent_p.A88A	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	88					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		ATGTTAAAGCCCGACCTTATC	0.378000													18	31					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43820887	43820887	+	Silent	SNP	T	T	C			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr15:43820887T>C	ENST00000382031.1	+	5	7961	c.7930T>C	c.(7930-7932)Ttg>Ctg	p.L2644L	MAP1A_ENST00000300231.5_Silent_p.L2406L|MAP1A_ENST00000399453.1_Silent_p.L2406L			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2406						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GCCTGACACATTGCTCTCCCC	0.672000													14	30					0	0	1	0	0
PRSS57	400668	broad.mit.edu	37	19	686939	686939	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr19:686939G>A	ENST00000329267.7	-	4	660	c.631C>T	c.(631-633)Cgg>Tgg	p.R211W		NM_214710.3	NP_999875.1	Q6UWY2	PRS57_HUMAN	protease, serine, 57	211	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|lung(5)	6						CAGAAGCCCCGTCTGTGGCTG	0.637000													7	62					0	0	1	0	0
GNPAT	8443	broad.mit.edu	37	1	231401763	231401763	+	Missense_Mutation	SNP	T	T	G			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr1:231401763T>G	ENST00000366647.4	+	7	945	c.776T>G	c.(775-777)cTt>cGt	p.L259R	GNPAT_ENST00000366646.3_Missense_Mutation_p.L198R	NM_014236.3	NP_055051.1	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	259					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	23	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				TTTGCAGGTCTTCTGAATATT	0.343000													15	32					0	0	1	0	0
EYA3	2140	broad.mit.edu	37	1	28384518	28384518	+	Nonsense_Mutation	SNP	A	A	T			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr1:28384518A>T	ENST00000373871.3	-	2	260	c.20T>A	c.(19-21)tTa>tAa	p.L7*	EYA3_ENST00000545175.1_5'UTR|EYA3_ENST00000471498.1_5'UTR|EYA3_ENST00000373863.3_Nonsense_Mutation_p.L7*|EYA3_ENST00000373864.1_5'UTR|EYA3_ENST00000540618.1_Nonsense_Mutation_p.L7*|EYA3_ENST00000436342.2_5'UTR			Q99504	EYA3_HUMAN	eyes absent homolog 3 (Drosophila)	7					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		TTGCTCTGGTAAATCTTGCTC	0.303000													24	59					0	0	1	0	0
DDX42	11325	broad.mit.edu	37	17	61885144	61885144	+	Missense_Mutation	SNP	A	A	G			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr17:61885144A>G	ENST00000578681.1	+	10	1508	c.907A>G	c.(907-909)Aaa>Gaa	p.K303E	DDX42_ENST00000359353.5_Missense_Mutation_p.K184E|DDX42_ENST00000457800.2_Missense_Mutation_p.K303E|DDX42_ENST00000389924.2_Missense_Mutation_p.K303E|DDX42_ENST00000583590.1_Missense_Mutation_p.K303E	NM_007372.2	NP_031398.2	Q86XP3	DDX42_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 42	303	Helicase ATP-binding.				protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)	46						AGGTAGTGGGAAAACTGCAGC	0.423000													45	84					0	0	1	0	0
ZBTB18	10472	broad.mit.edu	37	1	244217471	244217471	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr1:244217471C>T	ENST00000358704.4	+	2	544	c.395C>T	c.(394-396)aCg>aTg	p.T132M		NM_001278196.1|NM_006352.4|NM_205768.2	NP_001265125.1|NP_006343.2|NP_991331.1			zinc finger and BTB domain containing 18																		AAAGCCACCACGGAGGCAGAC	0.488000													8	30					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30695301	30695301	+	Missense_Mutation	SNP	A	A	T			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr8:30695301A>T	ENST00000256246.2	-	3	7424	c.7350T>A	c.(7348-7350)gaT>gaA	p.D2450E		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	2450										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AATCTTTCTTATCACTTTTTG	0.348000													40	147					0	0	1	0	0
PACRGL	133015	broad.mit.edu	37	4	20715141	20715141	+	Missense_Mutation	SNP	T	T	A			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr4:20715141T>A	ENST00000360916.5	+	7	979	c.588T>A	c.(586-588)caT>caA	p.H196Q	PACRGL_ENST00000295290.8_Missense_Mutation_p.H196Q|PACRGL_ENST00000444671.2_Missense_Mutation_p.H98Q|PACRGL_ENST00000507634.1_Missense_Mutation_p.H196Q|PACRGL_ENST00000503585.1_Missense_Mutation_p.H196Q|PACRGL_ENST00000502938.1_Intron|PACRGL_ENST00000538990.1_Missense_Mutation_p.H98Q|PACRGL_ENST00000502374.1_Missense_Mutation_p.H143Q|PACRGL_ENST00000513459.1_Missense_Mutation_p.H143Q	NM_145048.3	NP_659485.1	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like	196							binding			endometrium(2)|lung(7)|prostate(1)	10						TAAACGACCATCTGAAGCATC	0.388000													13	63					0	0	1	0	0
KCNG1	3755	broad.mit.edu	37	20	49620640	49620640	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr20:49620640C>T	ENST00000371571.4	-	3	1763	c.1478G>A	c.(1477-1479)aGc>aAc	p.S493N	RP5-955M13.3_ENST00000506387.1_RNA|RP5-955M13.4_ENST00000424566.1_RNA	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	493						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						CTGGGACACGCTCAGCTGCGA	0.587000													20	36					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37745028	37745028	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr9:37745028C>T	ENST00000539465.1	+	16	3592	c.2999C>T	c.(2998-3000)gCc>gTc	p.A1000V	FRMPD1_ENST00000377765.3_Missense_Mutation_p.A1000V|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1000						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GATGGGATTGCCCCCAAAGAA	0.547000													4	135					0	0	1	0	0
USP10	9100	broad.mit.edu	37	16	84797774	84797774	+	Silent	SNP	A	A	G			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr16:84797774A>G	ENST00000219473.7	+	10	1850	c.1737A>G	c.(1735-1737)gaA>gaG	p.E579E	USP10_ENST00000570191.1_Silent_p.E583E	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	579					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						GCGAGGATGAATGGGAACAAG	0.507000													18	42					0	0	1	0	0
SPG21	51324	broad.mit.edu	37	15	65257674	65257674	+	Missense_Mutation	SNP	T	T	C			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr15:65257674T>C	ENST00000559199.1	-	6	1335	c.335A>G	c.(334-336)aAt>aGt	p.N112S	SPG21_ENST00000204566.2_Missense_Mutation_p.N266S|SPG21_ENST00000433215.2_Missense_Mutation_p.N266S|SPG21_ENST00000416889.2_Missense_Mutation_p.N239S			Q9NZD8	SPG21_HUMAN	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	266					cell death	cytosol|endosome membrane|trans-Golgi network transport vesicle	CD4 receptor binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|urinary_tract(1)	10						TACATAAAGATTGACCTCTGC	0.423000													15	50					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16946438	16946438	+	RNA	SNP	G	G	A	rs28392876	by1000genomes	TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr1:16946438G>A	ENST00000412962.1	-	0	1081																											GCCTTCCGCCGGGCCAGCAGC	0.672000													4	47					0	0	1	0	0
RNMT	8731	broad.mit.edu	37	18	13734551	13734551	+	Missense_Mutation	SNP	T	T	A			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr18:13734551T>A	ENST00000383314.2	+	4	746	c.506T>A	c.(505-507)aTt>aAt	p.I169N	RNMT_ENST00000589866.1_Missense_Mutation_p.I169N|RNMT_ENST00000592764.1_Missense_Mutation_p.I169N|RNMT_ENST00000543302.2_Missense_Mutation_p.I169N|RNMT_ENST00000535051.1_5'UTR|RNMT_ENST00000262173.3_Missense_Mutation_p.I169N			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	169					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						CAAAGTCGTATTTTTTACCTA	0.353000													20	28					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182015	57182015	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr4:57182015G>A	ENST00000504228.1	+	6	2452	c.2347G>A	c.(2347-2349)Gca>Aca	p.A783T	KIAA1211_ENST00000264229.6_Missense_Mutation_p.A783T|KIAA1211_ENST00000541073.1_Missense_Mutation_p.A776T			Q6ZU35	K1211_HUMAN	KIAA1211	783										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CCGGGAGCCCGCAGACACCAC	0.617000													35	69					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				19	52					0	0	1	0	0
AC006293.3	0	broad.mit.edu	37	19	55221559	55221559	+	RNA	SNP	G	G	T			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr19:55221559G>T	ENST00000413439.1	+	0	1339																											ACGGGGGCCAGTACAGATGCT	0.672000													4	64					0.0215528	0.0220784	1	1	0
UBXN2B	137886	broad.mit.edu	37	8	59347057	59347057	+	Missense_Mutation	SNP	A	A	G			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr8:59347057A>G	ENST00000399598.2	+	5	649	c.527A>G	c.(526-528)aAg>aGg	p.K176R	UBXN2B_ENST00000522978.1_3'UTR	NM_001077619.1	NP_001071087.1	Q14CS0	UBX2B_HUMAN	UBX domain protein 2B	176	SEP.					cytosol|endoplasmic reticulum|Golgi apparatus|nucleus				endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	13						GAGTCTGTTAAGAGAGGGTAA	0.348000													11	23					0	0	1	0	0
KNCN	148930	broad.mit.edu	37	1	47013416	47013416	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr1:47013416delC	ENST00000481882.2	-	4	672	c.361delG	c.(361-363)ctfs	p.A121fs	KNCN_ENST00000396314.3_Frame_Shift_Del_p.A98fs|MKNK1-AS1_ENST00000602433.1_RNA|KNCN_ENST00000524908.1_5'UTR			A6PVL3	KNCN_HUMAN	kinocilin	121						integral to membrane				central_nervous_system(1)|endometrium(1)|lung(1)|ovary(1)	4	Acute lymphoblastic leukemia(166;0.155)					CATTCCTCAGCCCCCCGGGTC	0.672													2	4	---	---	---	---					
RP11-3B12.1	0	broad.mit.edu	37	7	124674953	124674953	+	RNA	DEL	C	C	-			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr7:124674953delC	ENST00000453342.1	+	0	614																											AGGACACACTCCTTGTGGCAC	0.537													2	4	---	---	---	---					
UTP20	27340	broad.mit.edu	37	12	101680156	101680157	+	Frame_Shift_Ins	INS	-	-	T			TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr12:101680156_101680157insT	ENST00000261637.4	+	5	558_559	c.384_385insT	c.(382-387)gattttfs	p.DF128fs		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	128					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						ACTTTCCAGAGTTTTTTTTGAC	0.396													10	258	---	---	---	---					
RP11-478C19.2	0	broad.mit.edu	37	12	110868215	110868216	+	RNA	DEL	GT	GT	-	rs113592903		TCGA-J8-A3YF-01A-12D-A23M-08	TCGA-J8-A3YF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26ef9ead-6e4c-4ba0-ad48-e15384200468	412691cf-393d-4275-803e-b063ab91bf0d	g.chr12:110868215_110868216delGT	ENST00000550231.1	-	0	97																											CAgtgtgtgcgtgtgtgtgtgt	0.490													2	4	---	---	---	---