Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DLGAP2	9228	broad.mit.edu	37	8	1497493	1497493	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr8:1497493G>A	ENST00000421627.2	+	2	768	c.634G>A	c.(634-636)Ggc>Agc	p.G212S		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	291					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GCCCCGGCCCGGCATGAGCAG	0.706000													17	36					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45262298	45262298	+	Missense_Mutation	SNP	G	G	C			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr5:45262298G>C	ENST00000303230.4	-	8	2455	c.2398C>G	c.(2398-2400)Ctg>Gtg	p.L800V		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	800						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CTGGAAATCAGAGTGGACACC	0.657000													14	50					0	0	1	0	0
WDR66	144406	broad.mit.edu	37	12	122359475	122359475	+	Silent	SNP	G	G	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr12:122359475G>A	ENST00000288912.4	+	2	1118	c.264G>A	c.(262-264)gaG>gaA	p.E88E	WDR66_ENST00000397454.2_Silent_p.E88E	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	88	Glu-rich.						calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		AAGAGAAGGAGGCTTCAGGAA	0.498000													15	59					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101764298	101764298	+	Missense_Mutation	SNP	T	T	G			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr12:101764298T>G	ENST00000261637.4	+	50	6818	c.6644T>G	c.(6643-6645)aTt>aGt	p.I2215S		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	2215					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						GAGGAGGACATTTATGATACT	0.418000													28	88					0	0	1	0	0
TMEM104	54868	broad.mit.edu	37	17	72832366	72832366	+	Missense_Mutation	SNP	G	G	A	rs146892063	byFrequency	TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr17:72832366G>A	ENST00000335464.5	+	10	1193	c.1031G>A	c.(1030-1032)cGc>cAc	p.R344H	TMEM104_ENST00000417024.2_Intron|TMEM104_ENST00000582330.1_Missense_Mutation_p.R344H|TMEM104_ENST00000582773.1_Intron	NM_017728.3	NP_060198.3	Q8NE00	TM104_HUMAN	transmembrane protein 104	344						integral to membrane				NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(5)|ovary(1)	19	all_lung(278;0.23)					AACTTCGCGCGCTGTGACGTC	0.617000													8	210					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11561768	11561768	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr1:11561768C>T	ENST00000294484.6	+	2	857	c.719C>T	c.(718-720)gCg>gTg	p.A240V	PTCHD2_ENST00000389575.3_Missense_Mutation_p.A240V	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	240					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CCGCCCCACGCGGCAGTCGCG	0.687000													4	9					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	93518540	93518540	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr13:93518540C>T	ENST00000377067.3	+	8	1939	c.1567C>T	c.(1567-1569)Cca>Tca	p.P523S		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	523						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TACAGGGATGCCAGATGATAT	0.433000													7	43					0	0	1	0	0
IGHV1OR21-1	0	broad.mit.edu	37	21	10862774	10862774	+	RNA	SNP	G	G	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr21:10862774G>A	ENST00000559480.1	+	0	70																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						GGTACAGCTGGTGCAGTCTGG	0.552000													29	343					0	0	1	0	0
AZGP1P1	0	broad.mit.edu	37	7	99578411	99578411	+	RNA	SNP	T	T	C	rs62484970	by1000genomes	TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr7:99578411T>C	ENST00000425474.1	+	0	27					NR_036679.1																						AAGAATGGTGTCTGTCCTGCT	0.582000													6	126					0	0	1	0	0
PHAX	51808	broad.mit.edu	37	5	125960507	125960507	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr5:125960507G>A	ENST00000297540.4	+	5	1851	c.1156G>A	c.(1156-1158)Gat>Aat	p.D386N		NM_032177.3	NP_115553.2	Q9H814	PHAX_HUMAN	phosphorylated adaptor for RNA export	386					ncRNA metabolic process|protein transport|snRNA export from nucleus|spliceosomal snRNP assembly	Cajal body|cytosol	RNA binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	8						CATTGAAGTTGATCATTCTCA	0.388000													14	53					0	0	1	0	0
PPAN-P2RY11	0	broad.mit.edu	37	19	10220890	10220890	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr19:10220890C>T	ENST00000428358.1	+	8	962	c.790C>T	c.(790-792)Cgg>Tgg	p.R264W	PPAN_ENST00000393793.1_Missense_Mutation_p.R211W|PPAN_ENST00000253107.7_Missense_Mutation_p.R264W|PPAN_ENST00000556468.1_Missense_Mutation_p.R264W|PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.R264W	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		264	Brix.				RNA splicing	nucleolus	protein binding	p.R264W(2)		breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			TGGCAACATGCGGGCCCAGCA	0.692000													3	25					0	0	1	0	0
CNTNAP3B	728577	broad.mit.edu	37	9	43915893	43915893	+	Missense_Mutation	SNP	G	G	C	rs143747399	by1000genomes	TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr9:43915893G>C	ENST00000377564.3	+	23	4134	c.3741G>C	c.(3739-3741)atG>atC	p.M1247I		NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	1247					cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						CTGCTGTCATGGGAGGTAACA	0.433000													5	41					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr12:25398284C>A	ENST00000311936.3	-	2	226	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000256078.4_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			3	17					0.115264	0.115264	1	1	0
HIRIP3	8479	broad.mit.edu	37	16	30006000	30006000	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr16:30006000C>T	ENST00000279392.3	-	4	1296	c.466G>A	c.(466-468)Gga>Aga	p.G156R	HIRIP3_ENST00000564026.1_Intron	NM_003609.4	NP_003600.2	Q9BW71	HIRP3_HUMAN	HIRA interacting protein 3	156	Glu-rich.				chromatin assembly or disassembly	nucleus	protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(9)	17						CTCTCCTCTCCCCTCTGTGCG	0.567000													61	224					0	0	1	0	0
MOCS3	27304	broad.mit.edu	37	20	49576665	49576665	+	Nonsense_Mutation	SNP	C	C	G			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr20:49576665C>G	ENST00000244051.1	+	1	1303	c.1286C>G	c.(1285-1287)tCa>tGa	p.S429*		NM_014484.3	NP_055299.1	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	429	Rhodanese.		S -> A (in dbSNP:rs7269297).		enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	24						CAGTCCTTATCAGCAGCTCAA	0.507000													29	87					0	0	1	0	0
GPR42	2866	broad.mit.edu	37	19	35863030	35863030	+	Missense_Mutation	SNP	T	T	G			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr19:35863030T>G	ENST00000454971.1	+	2	970	c.769T>G	c.(769-771)Tgg>Ggg	p.W257G	GPR42_ENST00000597214.1_Missense_Mutation_p.W257G					G protein-coupled receptor 42 (gene/pseudogene)											endometrium(1)|kidney(1)|skin(2)	4	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			AAGCCCGGTGTGGAGGATCTA	0.587000													33	122					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51863511	51863511	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr12:51863511C>T	ENST00000453097.2	+	12	1680	c.1463C>T	c.(1462-1464)gCc>gTc	p.A488V	SLC4A8_ENST00000546663.1_3'UTR|SLC4A8_ENST00000535225.2_Missense_Mutation_p.A435V|SLC4A8_ENST00000514353.3_Missense_Mutation_p.A435V|SLC4A8_ENST00000394856.1_Missense_Mutation_p.A435V|SLC4A8_ENST00000358657.3_Missense_Mutation_p.A515V	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	488					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		CTGTACTGTGCCTGCATGTCA	0.512000													19	82					0	0	1	0	0
POR	5447	broad.mit.edu	37	7	75614476	75614476	+	Missense_Mutation	SNP	T	T	C			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr7:75614476T>C	ENST00000394893.1	+	12	1369	c.1349T>C	c.(1348-1350)cTg>cCg	p.L450P	POR_ENST00000461988.1_Missense_Mutation_p.L450P|POR_ENST00000419840.1_Missense_Mutation_p.L264P|POR_ENST00000450476.1_Missense_Mutation_p.L349P|POR_ENST00000545601.1_Missense_Mutation_p.L258P|POR_ENST00000439269.1_Missense_Mutation_p.L188P			P16435	NCPR_HUMAN	P450 (cytochrome) oxidoreductase	447	FAD-binding FR-type.				cellular organofluorine metabolic process|positive regulation of monooxygenase activity	endoplasmic reticulum membrane	iron ion binding|NADPH-hemoprotein reductase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|lung(3)|ovary(1)	9					Benzphetamine(DB00865)|Daunorubicin(DB00694)|Lipoic Acid(DB00166)|Menadione(DB00170)|Methoxyflurane(DB01028)|Mitomycin(DB00305)|Nilutamide(DB00665)	CTGTGTGAGCTGCTGCCGCGC	0.697000													6	35					0	0	1	0	0
COG4	25839	broad.mit.edu	37	16	70530189	70530189	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr16:70530189C>T	ENST00000323786.5	-	12	1648	c.1627G>A	c.(1627-1629)Gag>Aag	p.E543K		NM_001195139.1|NM_015386.2	NP_001182068.1|NP_056201.2	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	539					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|pancreas(1)|prostate(2)	33		Ovarian(137;0.0694)				ATCTTCGCCTCGTCAGTACTC	0.527000													9	36					0	0	1	0	0
PC	5091	broad.mit.edu	37	11	66617415	66617415	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr11:66617415C>T	ENST00000393960.1	-	20	3172	c.2891G>A	c.(2890-2892)cGc>cAc	p.R964H	PC_ENST00000393955.2_Missense_Mutation_p.R964H|PC_ENST00000529047.1_Missense_Mutation_p.R84H|PC_ENST00000393958.2_Missense_Mutation_p.R964H	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	964					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	TACCTTAGAGCGAAAGGGTTC	0.627000													13	45					0	0	1	0	0
SH3BP4	23677	broad.mit.edu	37	2	235950264	235950264	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr2:235950264G>A	ENST00000409212.1	+	4	1358	c.851G>A	c.(850-852)cGa>cAa	p.R284Q	SH3BP4_ENST00000344528.4_Missense_Mutation_p.R284Q|SH3BP4_ENST00000392011.2_Missense_Mutation_p.R284Q			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	284					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GAGGATTTTCGAACTGCCTGG	0.592000													28	69					0	0	1	0	0
PTTG1IP	754	broad.mit.edu	37	21	46276212	46276212	+	Silent	SNP	G	G	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr21:46276212G>A	ENST00000330938.3	-	4	565	c.345C>T	c.(343-345)atC>atT	p.I115I	PTTG1IP_ENST00000445724.2_Intron|PTTG1IP_ENST00000494690.1_5'UTR|PTTG1IP_ENST00000397887.3_Intron|PTTG1IP_ENST00000397886.3_Silent_p.I94I	NM_004339.3	NP_004330.1	P53801	PTTG_HUMAN	pituitary tumor-transforming 1 interacting protein	115					protein import into nucleus	cytoplasm|integral to membrane|nucleus				ovary(1)|prostate(1)	2				Colorectal(79;0.0659)		AGCAGCAGCAGATGGCAATGC	0.622000													9	49					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1083312	1083312	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr11:1083312G>A	ENST00000441003.2	+	16	2239	c.2212G>A	c.(2212-2214)Gaa>Aaa	p.E738K	MUC2_ENST00000359061.5_Missense_Mutation_p.E738K	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	738						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CAGGCAGGAAGAACGATGGTG	0.662000													6	13					0	0	1	0	0
PTPN13	0	broad.mit.edu	37	4	87724940	87724940	+	Missense_Mutation	SNP	C	C	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr4:87724940C>A	ENST00000436978.1	+	43	7079	c.6599C>A	c.(6598-6600)gCc>gAc	p.A2200D	PTPN13_ENST00000316707.6_Missense_Mutation_p.A2004D|PTPN13_ENST00000511467.1_Missense_Mutation_p.A2200D|PTPN13_ENST00000427191.2_Missense_Mutation_p.A2176D|PTPN13_ENST00000411767.2_Missense_Mutation_p.A2195D	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	2195						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TACACGGGTGCCAACTTAAAA	0.463000													11	103					1.08611e-07	1.14041e-07	1	1	0
RTF1	23168	broad.mit.edu	37	15	41750043	41750043	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr15:41750043C>T	ENST00000389629.4	+	4	643	c.631C>T	c.(631-633)Cgc>Tgc	p.R211C		NM_015138.4	NP_055953.3	Q92541	RTF1_HUMAN	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	211	Glu-rich.				histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	18		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		ACTGTTCAATCGCATAGAGAA	0.502000													22	76					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14620522	14620522	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr7:14620522C>T	ENST00000403951.2	-	19	1996	c.1577G>A	c.(1576-1578)gGc>gAc	p.G526D	DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000407950.1_Missense_Mutation_p.G518D|DGKB_ENST00000406247.3_Missense_Mutation_p.G526D|DGKB_ENST00000258767.5_Missense_Mutation_p.G526D|DGKB_ENST00000399322.3_Missense_Mutation_p.G526D|DGKB_ENST00000444700.2_Missense_Mutation_p.G507D|DGKB_ENST00000402815.1_Missense_Mutation_p.G525D			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	526	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	TAGATCATTGCCAGTCCCAAG	0.418000													16	27					0	0	1	0	0
WDR54	84058	broad.mit.edu	37	2	74652207	74652207	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr2:74652207C>T	ENST00000348227.4	+	8	729	c.641C>T	c.(640-642)cCg>cTg	p.P214L	WDR54_ENST00000409791.1_Missense_Mutation_p.P162L|WDR54_ENST00000461531.1_3'UTR	NM_032118.2	NP_115494.1	Q9H977	WDR54_HUMAN	WD repeat domain 54	214										breast(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	9						TGCAGAGTTCCGTGCCCCTCT	0.532000													15	39					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871052	170871052	+	Silent	SNP	G	G	A	rs112083427		TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr6:170871052G>A	ENST00000392092.2	+	3	507	c.228G>A	c.(226-228)caG>caA	p.Q76Q	TBP_ENST00000540980.1_Silent_p.Q56Q|TBP_ENST00000230354.6_Silent_p.Q76Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	76	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q76Q(4)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcaacagcagcagcagcagc	0.572000													11	56					0	0	1	0	0
PALM2-AKAP2	0	broad.mit.edu	37	9	112899916	112899916	+	Missense_Mutation	SNP	A	A	G			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr9:112899916A>G	ENST00000374530.3	+	8	2272	c.2092A>G	c.(2092-2094)Acc>Gcc	p.T698A	PALM2-AKAP2_ENST00000302798.7_Missense_Mutation_p.T698A|AKAP2_ENST00000555236.1_Missense_Mutation_p.T698A|AKAP2_ENST00000259318.7_Missense_Mutation_p.T467A|AKAP2_ENST00000510514.5_Missense_Mutation_p.T698A|AKAP2_ENST00000434623.2_Missense_Mutation_p.T556A|AKAP2_ENST00000374525.1_Missense_Mutation_p.T556A	NM_007203.4|NM_147150.2	NP_009134.1|NP_671492.1	Q9Y2D5	AKAP2_HUMAN		467							enzyme binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	44						TGTCTCCTTGACCCAAGAGGA	0.502000													21	88					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8218801	8218801	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr4:8218801C>T	ENST00000539824.1	+	7	892	c.518C>T	c.(517-519)gCc>gTc	p.A173V	SH3TC1_ENST00000245105.3_Missense_Mutation_p.A249V			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	249							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						GGAGAGGCGGCCCCGGAAACA	0.657000													7	39					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119214632	119214632	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr11:119214632C>A	ENST00000555262.1	-	9	1177	c.1018G>T	c.(1018-1020)Gaa>Taa	p.E340*	MFRP_ENST00000449574.2_Nonsense_Mutation_p.E340*|C1QTNF5_ENST00000445041.2_5'UTR|MFRP_ENST00000530681.1_Nonsense_Mutation_p.E340*|MFRP_ENST00000360167.4_Intron	NM_001278431.1	NP_001265360.1			membrane frizzled-related protein											autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|urinary_tract(1)	18		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		AACTGTAGTTCTATGCTGTGT	0.582000													25	73					2.41591e-17	2.5797e-17	1	1	0
TRIM23	373	broad.mit.edu	37	5	64887703	64887703	+	Missense_Mutation	SNP	T	T	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr5:64887703T>A	ENST00000231524.9	-	11	1989	c.1618A>T	c.(1618-1620)Agc>Tgc	p.S540C	TRIM23_ENST00000381018.3_Missense_Mutation_p.S540C|TRIM23_ENST00000274327.7_Missense_Mutation_p.S540C	NM_001656.3	NP_001647.1	P36406	TRI23_HUMAN	tripartite motif containing 23	540	ARF-like.				interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	28		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		ATATACCAGCTACGGCCACAG	0.438000													10	62					0	0	1	0	0
NGF	4803	broad.mit.edu	37	1	115828787	115828787	+	Silent	SNP	C	C	T	rs112292538		TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr1:115828787C>T	ENST00000369512.2	-	3	798	c.630G>A	c.(628-630)gcG>gcA	p.A210A	RP4-663N10.1_ENST00000425449.1_RNA	NM_002506.2	NP_002497.2	P01138	NGF_HUMAN	nerve growth factor (beta polypeptide)	210					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	CCATGGTCAGCGCCTTGACAA	0.572000													27	74					0	0	1	0	0
ANKLE1	126549	broad.mit.edu	37	19	17396247	17396247	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr19:17396247C>T	ENST00000394458.3	+	7	1660	c.1384C>T	c.(1384-1386)Cag>Tag	p.Q462*	ANKLE1_ENST00000598347.1_Nonsense_Mutation_p.Q436*|ANKLE1_ENST00000433424.2_Silent_p.L430L|ANKLE1_ENST00000404085.1_Nonsense_Mutation_p.Q458*|ANKLE1_ENST00000594072.1_Nonsense_Mutation_p.Q425*	NM_152363.4	NP_689576.4	Q8NAG6	ANKL1_HUMAN	ankyrin repeat and LEM domain containing 1	462						nuclear envelope				large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	7						CAGGGAGACTCAGGACCTGCC	0.567000													33	101					0	0	1	0	0
LRRC37A11P	0	broad.mit.edu	37	17	37186422	37186422	+	RNA	SNP	G	G	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr17:37186422G>A	ENST00000425901.2	+	0	264					NR_033753.2																						TGTTAATAATGAGAACCCCTC	0.547000													10	66					0	0	1	0	0
BIN1	274	broad.mit.edu	37	2	127821186	127821186	+	Silent	SNP	G	G	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr2:127821186G>A	ENST00000316724.5	-	9	1146	c.735C>T	c.(733-735)atC>atT	p.I245I	BIN1_ENST00000466111.1_5'UTR|BIN1_ENST00000259238.4_Silent_p.I214I|BIN1_ENST00000352848.3_Silent_p.I214I|BIN1_ENST00000376113.2_Silent_p.I214I|BIN1_ENST00000409400.1_Silent_p.I214I|BIN1_ENST00000393041.3_Silent_p.I214I|BIN1_ENST00000346226.3_Silent_p.I214I|BIN1_ENST00000357970.3_Silent_p.I245I|BIN1_ENST00000348750.4_Silent_p.I214I|BIN1_ENST00000393040.3_Silent_p.I214I|BIN1_ENST00000351659.3_Silent_p.I245I	NM_139343.2	NP_647593.1	O00499	BIN1_HUMAN	bridging integrator 1	245	BAR.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)	24	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CCAGGCCCGCGATGCTCTGGA	0.597000													7	21					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121437783	121437783	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr11:121437783C>T	ENST00000260197.7	+	22	3313	c.3184C>T	c.(3184-3186)Cag>Tag	p.Q1062*	SORL1_ENST00000525532.1_Nonsense_Mutation_p.Q6*	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1062	EGF-like.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TGACTGCCCTCAGGGCTATCA	0.527000													7	32					0	0	1	0	0
CGRRF1	10668	broad.mit.edu	37	14	54976644	54976644	+	Translation_Start_Site	SNP	G	G	A	rs75987656	byFrequency	TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr14:54976644G>A	ENST00000216420.7	+	0	99					NM_006568.2	NP_006559.1	Q99675	CGRF1_HUMAN	cell growth regulator with ring finger domain 1						cell cycle arrest|negative regulation of cell proliferation|response to stress		zinc ion binding			endometrium(3)|kidney(2)|lung(5)|ovary(2)|stomach(1)	13						gggctccgcggctggagccgg	0.622000											OREG0022692	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	58					0	0	1	0	0
FKBP9	11328	broad.mit.edu	37	7	33014319	33014319	+	Silent	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr7:33014319C>T	ENST00000242209.4	+	2	481	c.312C>T	c.(310-312)aaC>aaT	p.N104N	FKBP9_ENST00000538336.1_Silent_p.N157N|AVL9_ENST00000404479.1_Intron|FKBP9_ENST00000538443.1_Intron	NM_007270.3	NP_009201.2	O95302	FKBP9_HUMAN	FK506 binding protein 9, 63 kDa	104	PPIase FKBP-type 1.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity	p.N104K(1)		central_nervous_system(13)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	39			GBM - Glioblastoma multiforme(11;0.0156)			TGTGCGTAAACGAGAGACGTT	0.468000													22	99					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				10	54					0	0	1	0	0
FAM19A5	25817	broad.mit.edu	37	22	49042492	49042492	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr22:49042492G>A	ENST00000358295.5	+	2	350	c.175G>A	c.(175-177)Gcc>Acc	p.A59T	FAM19A5_ENST00000473898.1_Intron|FAM19A5_ENST00000402357.1_Missense_Mutation_p.A66T	NM_015381.5	NP_056196.2	Q7Z5A7	F19A5_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A5	66						extracellular region|integral to membrane				large_intestine(1)|lung(6)	7		all_cancers(38;2.95e-11)|all_epithelial(38;3.07e-10)|all_lung(38;2.89e-05)|Breast(42;0.000396)|Lung NSC(38;0.000471)|Ovarian(80;0.00934)|Lung SC(80;0.195)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0227)|BRCA - Breast invasive adenocarcinoma(115;0.119)		CCGGCAGACCGCCCGCTGTGC	0.697000													6	11					0	0	1	0	0
C16orf82	0	broad.mit.edu	37	16	27078386	27078386	+	RNA	SNP	G	G	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr16:27078386G>A	ENST00000505035.1	+	0	359				RP11-673P17.2_ENST00000565783.1_RNA			Q7Z2V1	TNT_HUMAN																			TGTCCAGAATGAGCAGGAAGG	0.587000													7	24					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35551536	35551536	+	Missense_Mutation	SNP	A	A	G			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr19:35551536A>G	ENST00000262626.2	+	9	1451	c.626A>G	c.(625-627)aAc>aGc	p.N209S	HPN_ENST00000597419.1_Missense_Mutation_p.N51S|HPN_ENST00000392226.1_Missense_Mutation_p.N209S|HPN-AS1_ENST00000392227.2_RNA	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	209	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GGTAGGCGGAACCGGGTCCTG	0.692000													14	38					0	0	1	0	0
CRHR1	1394	broad.mit.edu	37	17	43907507	43907507	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr17:43907507C>T	ENST00000314537.5	+	6	707	c.482C>T	c.(481-483)gCc>gTc	p.A161V	CRHR1_ENST00000398285.3_Missense_Mutation_p.A190V|CRHR1_ENST00000577353.1_Missense_Mutation_p.A161V|CRHR1_ENST00000339069.5_Missense_Mutation_p.A60V|CRHR1_ENST00000352855.5_Missense_Mutation_p.A121V|CRHR1_ENST00000293493.7_5'UTR	NM_001145147.1|NM_001145148.1|NM_004382.4	NP_001138619.1|NP_001138620.1|NP_004373.2	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	190					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		CTCATCTCCGCCTTCATCCTG	0.627000													15	84					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133760038	133760038	+	Silent	SNP	G	G	A			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr9:133760038G>A	ENST00000318560.5	+	11	2742	c.2361G>A	c.(2359-2361)gtG>gtA	p.V787V		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	787	Pro-rich.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CCAGGCTGGTGAAAAAGAATG	0.612000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								22	27					0	0	1	0	0
AP5B1	91056	broad.mit.edu	37	11	65546685	65546685	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr11:65546685C>T	ENST00000532090.2	-	2	1489	c.1279G>A	c.(1279-1281)Gaa>Aaa	p.E427K		NM_138368.4	NP_612377.4	Q2VPB7	YK046_HUMAN	adaptor-related protein complex 5, beta 1 subunit	370							protein binding			lung(1)	1						TCCTCTTCTTCCTCCTCGGCA	0.667000													7	28					0	0	1	0	0
VARS2	57176	broad.mit.edu	37	6	30885522	30885522	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr6:30885522delC	ENST00000321897.5	+	9	1556	c.924delC	c.(922-924)tgfs	p.C308fs	VARS2_ENST00000541562.1_Frame_Shift_Del_p.C338fs|VARS2_ENST00000416670.2_Frame_Shift_Del_p.C308fs|VARS2_ENST00000542001.1_Frame_Shift_Del_p.C168fs			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	308					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						TGCCTGGCTGCCCCACCCCCG	0.612													2	4	---	---	---	---					
MROH6	642475	broad.mit.edu	37	8	144650732	144650733	+	Frame_Shift_Ins	INS	-	-	CC			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr8:144650732_144650733insCC	ENST00000398882.3	-	10	1889_1890	c.1633_1634insGG	c.(1633-1635)cgcfs	p.R545fs	MROH6_ENST00000534459.1_5'UTR|MROH6_ENST00000533679.1_5'UTR|MROH6_ENST00000524906.1_5'UTR	NM_001100878.1	NP_001094348.1			maestro heat-like repeat family member 6																		CTCAGCAGCGTCCCTGCTGGGG	0.698													2	4	---	---	---	---					
CADM1	23705	broad.mit.edu	37	11	115080312	115080314	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr11:115080312_115080314delTGG	ENST00000537058.1	-	8	1078_1080	c.1058_1060delCCA	c.(1057-1062)atc>a	p.TI353del	CADM1_ENST00000537140.1_Intron|CADM1_ENST00000542447.2_Intron|CADM1_ENST00000452722.2_In_Frame_Del_p.TI353del|CADM1_ENST00000536727.1_Intron|CADM1_ENST00000331581.6_In_Frame_Del_p.TI353del			Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	353				PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		atggtaaggatggtggtggtggt	0.429													7	75	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20138376	20138376	+	RNA	DEL	G	G	-	rs57620493		TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr14:20138376delG	ENST00000548261.1	+	0	391																											ACAaaagaaagaaagaaagaa	0.388													4	4	---	---	---	---					
TECPR2	9895	broad.mit.edu	37	14	102931589	102931591	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-J8-A4HY-01A-11D-A257-08	TCGA-J8-A4HY-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bca1d60-fb12-4191-aa19-883e5bd99996	b4f5c022-fbdd-4a29-b01b-0141efcf8dba	g.chr14:102931589_102931591delTGC	ENST00000359520.7	+	17	3978_3980	c.3752_3754delTGC	c.(3751-3756)att>a	p.ML1251del	TECPR2_ENST00000558678.1_In_Frame_Del_p.ML1251del	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	1251							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						CCCAGTCTCATGCTTCCAGCCTG	0.502													10	54	---	---	---	---