Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	rsID	rsID_ref_var_alleles	CAF	normal_ref_reads	normal_var_reads	normal_vaf	tumor_ref_reads	tumor_var_reads	tumor_vaf	normal_ref_reads_val	normal_var_reads_val	normal_vaf_val	tumor_ref_reads_val	tumor_var_reads_val	tumor_vaf_val
OCRL	0	genome.wustl.edu	37	X	128692701	128692701	+	Silent	SNP	C	C	A			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	X	128692701	128692701	C	A	SNP	OCRL	ENST00000371113	human	ensembl	74_37	1	known	silent	c.531	p.P177	0.486	NULL	pfam_Endo/exonuclease/phosphatase,pfam_RhoGAP_dom,superfamily_Endo/exonuclease/phosphatase,superfamily_Rho_GTPase_activation_prot,smart_IPPc,smart_RhoGAP_dom,pfscan_RhoGAP_dom	0	no_errors	0	0	0	152	0	0	105	80	43.24	284	1	0.35	187	79	29.70
FAM3A	0	genome.wustl.edu	37	X	153741210	153741210	+	Missense_Mutation	SNP	C	C	T			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	X	153741210	153741210	C	T	SNP	FAM3A	ENST00000359889	human	ensembl	74_37	-1	known	missense	c.64	p.V22M	0	NULL	NULL	0	no_errors	0	0	0	38	0	0	39	15	27.78	82	0	0.00	84	49	36.84
NEB	0	genome.wustl.edu	37	2	152497131	152497131	+	Missense_Mutation	SNP	G	G	A			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	2	152497131	152497131	G	A	SNP	NEB	ENST00000397345	human	ensembl	74_37	-1	known	missense	c.8423	p.A2808V	1	smart_Nebulin_35r-motif,pfscan_Nebulin_35r-motif	pfam_Nebulin_35r-motif,pfam_SH3_domain,pfam_SH3_2,superfamily_SH3_domain,superfamily_Adhesion_dom,superfamily_6-PGluconate_DH_C-like,smart_Nebulin_35r-motif,smart_SH3_domain,pfscan_Nebulin_35r-motif,pfscan_SH3_domain,prints_Nebulin	0	no_errors	0	0	0	48	0	0	39	20	33.9	41	0	0.00	15	9	37.50
TTN	0	genome.wustl.edu	37	2	179515498	179515498	+	Missense_Mutation	SNP	G	G	T			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	2	179515498	179515498	G	T	SNP	TTN	ENST00000342992	human	ensembl	74_37	-1	known	missense	c.32387	p.A10796E	0.054	pfam_PPAK_motif,superfamily_Calpain_domain_III,superfamily_RNaseH-like_dom	pfam_Ig_I-set,pfam_Fibronectin_type3,pfam_Immunoglobulin,pfam_Ig_V-set,pfam_Titin_Z,pfam_PPAK_motif,pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,superfamily_Fibronectin_type3,superfamily_Calpain_domain_III,superfamily_RNaseH-like_dom,smart_Ig_sub,smart_Ig_sub2,smart_Ig_V-set_subgr,smart_Fibronectin_type3,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Fibronectin_type3,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom	0	no_errors	0	0	0	102	0	0	71	60	45.8	178	1	0.56	132	53	28.65
LRFN2	0	genome.wustl.edu	37	6	40400316	40400316	+	Missense_Mutation	SNP	G	G	C			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	6	40400316	40400316	G	C	SNP	LRFN2	ENST00000338305	human	ensembl	74_37	-1	known	missense	c.537	p.S179R	1	smart_Leu-rich_rpt_typical-subtyp	pfam_Ig_I-set,pfam_Leu-rich_rpt,pfam_Fibronectin_type3,superfamily_Fibronectin_type3,smart_Leu-rich_rpt_typical-subtyp,smart_Cys-rich_flank_reg_C,smart_Ig_sub,smart_Ig_sub2,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	0	no_errors	0	0	0	23	0	0	19	7	26.92	85	0	0.00	77	31	28.70
GTF2I	0	genome.wustl.edu	37	7	74146970	74146970	+	Missense_Mutation	SNP	T	T	A			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	7	74146970	74146970	T	A	SNP	GTF2I	ENST00000324896	human	ensembl	74_37	1	known	missense	c.1271	p.L424H	1	pfam_GTF2I,superfamily_GTF2I,pirsf_TF_II-I,pfscan_GTF2I	pfam_GTF2I,superfamily_GTF2I,pirsf_TF_II-I,pfscan_GTF2I	0	no_errors	0	0	0	337	0	0	265	142	34.89	100	0	0.00	86	64	42.67
PLAG1	0	genome.wustl.edu	37	8	57079034	57079034	+	Missense_Mutation	SNP	A	A	C			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	8	57079034	57079034	A	C	SNP	PLAG1	ENST00000316981	human	ensembl	74_37	-1	known	missense	c.1271	p.F424C	1	NULL	smart_Znf_C2H2-like,pfscan_Znf_C2H2	0	no_errors	0	0	0	67	0	0	62	29	31.87	216	0	0.00	132	89	40.27
GARNL3	0	genome.wustl.edu	37	9	130149490	130149490	+	Missense_Mutation	SNP	G	G	A			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	9	130149490	130149490	G	A	SNP	GARNL3	ENST00000373387	human	ensembl	74_37	1	known	missense	c.2407	p.A803T	1	smart_Citron	pfam_Citron,pfam_Rap_GAP_dom,smart_Citron,pfscan_Rap_GAP_dom	0	no_errors	0	0	0	39	0	0	39	9	18.37	70	0	0.00	85	13	13.27
GTPBP4	0	genome.wustl.edu	37	10	1045028	1045028	+	Missense_Mutation	SNP	G	G	A			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	10	1045028	1045028	G	A	SNP	GTPBP4	ENST00000360803	human	ensembl	74_37	1	known	missense	c.647	p.R216H	1	pfam_GTP_binding_domain,pfam_Fe2_transport_prot_B_N,pfam_MIRO-like,superfamily_P-loop_NTPase,tigrfam_Small_GTP-bd_dom	pfam_NOG1_Rossman_fold_dom,pfam_NOG_C,pfam_GTP_binding_domain,pfam_Fe2_transport_prot_B_N,pfam_MIRO-like,superfamily_P-loop_NTPase,prints_GTP_binding_domain,tigrfam_Small_GTP-bd_dom	0	no_errors	rs566484717	G->A	0	101	0	0	82	31	27.43	191	0	0.00	121	76	38.38
YARS2	0	genome.wustl.edu	37	12	32908584	32908584	+	Silent	SNP	G	G	A			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	12	32908584	32908584	G	A	SNP	YARS2	ENST00000324868	human	ensembl	74_37	-1	known	silent	c.225	p.T75	0.003	pfam_aa-tRNA-synth_Ic,tigrfam_Tyr-tRNA-ligase	pfam_aa-tRNA-synth_Ic,prints_Tyr-tRNA-ligase,tigrfam_Tyr-tRNA-ligase	0	no_errors	rs376399300	G->A	0	75	0	0	51	33	39.29	154	0	0.00	102	45	30.61
KRT78	0	genome.wustl.edu	37	12	53242536	53242536	+	Missense_Mutation	SNP	C	C	A			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	12	53242536	53242536	C	A	SNP	KRT78	ENST00000304620	human	ensembl	74_37	-1	known	missense	c.179	p.G60V	0	NULL	pfam_IF,superfamily_Prefoldin,prints_Keratin_II	0	no_errors	0	0	0	37	0	0	36	24	40	99	0	0.00	82	23	21.70
MYH14	0	genome.wustl.edu	37	19	50762522	50762522	+	Missense_Mutation	SNP	G	G	A			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	19	50762522	50762522	G	A	SNP	MYH14	ENST00000262269	human	ensembl	74_37	1	known	missense	c.2354	p.R785Q	1	pfam_Myosin_head_motor_dom,superfamily_P-loop_NTPase,smart_Myosin_head_motor_dom	pfam_Myosin_head_motor_dom,pfam_Myosin_tail,pfam_Myosin_N,superfamily_P-loop_NTPase,superfamily_Prefoldin,smart_Myosin_head_motor_dom,smart_IQ_motif_EF-hand-BS,pfscan_IQ_motif_EF-hand-BS,prints_Myosin_head_motor_dom	0	no_errors	0	0	0	32	0	0	44	4	8.33	19	0	0.00	37	3	7.50
OTUD3	0	genome.wustl.edu	37	1	20216922	20216923	+	Frame_Shift_Ins	INS	-	-	A			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	-	-	-	A	-	-	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	1	20216922	20216923	0	A	INS	OTUD3	ENST00000375120	human	ensembl	74_37	1	known	frame_shift_ins	c.266_267	p.R90fs	1.000:0.968	pfam_OTU,pfscan_OTU	pfam_OTU,pfscan_OTU	0	no_errors	0	0	0	100	0	0	70	36	33.96	242	0	0.00	169	68	28.69
ZNF451	0	genome.wustl.edu	37	6	57012978	57012979	+	Frame_Shift_Ins	INS	-	-	A			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	-	-	-	A	-	-	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	6	57012978	57012979	0	A	INS	ZNF451	ENST00000370706	human	ensembl	74_37	1	known	frame_shift_ins	c.2095_2096	p.T701fs	1.000:1.000	NULL	smart_Znf_C2H2-like,pfscan_Znf_C2H2	0	no_errors	0	0	0	40	0	0	42	17	28.81	248	0	0.00	177	80	31.13
KRT78	0	genome.wustl.edu	37	12	53242534	53242534	+	Frame_Shift_Del	DEL	T	T	-			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	T	T	T	-	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	12	53242534	53242534	T	0	DEL	KRT78	ENST00000304620	human	ensembl	74_37	-1	known	frame_shift_del	c.181	p.R61fs	0.447	NULL	pfam_IF,superfamily_Prefoldin,prints_Keratin_II	0	no_errors	0	0	0	36	0	0	35	24	40.68	100	0	0.00	84	23	21.50
SETMAR	0	genome.wustl.edu	37	3	4358835	4358835	+	Nonsense_Mutation	SNP	G	G	T			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	3	4358835	4358835	G	T	SNP	SETMAR	ENST00000358065	human	ensembl	74_37	1	known	nonsense	c.1960	p.E654*	0.013	NULL	pfam_Transposase_1,pfam_SET_dom,pfam_Pre-SET_dom,pfam_Transposase_Tc1-like,pfam_Transposase_14,superfamily_Homeodomain-like,smart_Pre-SET_Zn-bd_sub,smart_SET_dom,pfscan_SET_dom,pfscan_Pre-SET_dom,pfscan_Post-SET_dom	0	no_errors	0	0	0	40	0	0	49	4	7.55	0	0	0.00	0	0	0.00
UNC93B1	0	genome.wustl.edu	37	11	67759145	67759145	+	Missense_Mutation	SNP	G	G	A			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	11	67759145	67759145	G	A	SNP	UNC93B1	ENST00000227471	human	ensembl	74_37	-1	known	missense	c.1663	p.H555Y	0.007	NULL	pfam_Ion_channel_UNC-93,superfamily_MFS_dom_general_subst_transpt	0	no_errors	0	0	0	21	1	4.55	31	3	8.82	0	0	0.00	2	0	0.00
NPIPB15	0	genome.wustl.edu	37	16	74425946	74425946	+	Nonsense_Mutation	SNP	C	C	T			TCGA-YT-A95D-01A-11D-A428-09	TCGA-YT-A95D-10A-01D-A42B-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	ec079557-d895-462c-afd9-44f85c99ee79	39a3be9a-abae-47c2-9880-fe2aa424c66c	16	74425946	74425946	C	T	SNP	NPIPB15	ENST00000429990	human	ensembl	74_37	1	known	nonsense	c.1300	p.Q434*	0.968	NULL	NULL	0	no_errors	rs369331764	C->T	0	29	1	3.23	62	8	11.43	0	0	0.00	0	0	0.00